ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV1427 good K KOG1875 Transcription Thyroid hormone receptor-associated coactivator complex component (TRAP170)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV1427 481450 478457 -998
(998 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR071c [K] KOG1875 Thyroid hormone receptor-associated coactiva... 849 0.0
7291979 [K] KOG1875 Thyroid hormone receptor-associated coactiva... 82 3e-15
CE20551 [K] KOG1875 Thyroid hormone receptor-associated coactiva... 68 8e-11
CE20550 [K] KOG1875 Thyroid hormone receptor-associated coactiva... 68 8e-11
Hs4758102 [K] KOG1875 Thyroid hormone receptor-associated coacti... 66 2e-10
At3g04740 [K] KOG1875 Thyroid hormone receptor-associated coacti... 55 4e-07
>YLR071c [K] KOG1875 Thyroid hormone receptor-associated coactivator complex
component (TRAP170)
Length = 1082
Score = 849 bits (2193), Expect = 0.0
Identities = 459/1038 (44%), Positives = 649/1038 (62%), Gaps = 119/1038 (11%)
Query: 28 PPPIPHVEMNQXXXXXXXXXXTVFTAKEISQFFKLNVHTGGKTPFE-KKLELLNMILFLR 86
PP +PHVE+NQ TVFT KE++Q+ K NVHT P KK+ L +I+FLR
Sbjct: 79 PPALPHVEINQVSLALVIRNLTVFTMKELAQYMKTNVHTQANEPNSAKKIRFLQLIIFLR 138
Query: 87 NQFLKLYVLVKWAKTLKQNNFHSLIDLLNWFRNANMQVNNCTMALKQILGTMAGAKLPNP 146
QFLKLYVLVKW +T+KQNNFH LIDLLNWFR NM VNNC ALK L +M AKLPN
Sbjct: 139 TQFLKLYVLVKWTRTIKQNNFHVLIDLLNWFRTTNMNVNNCIWALKSSLNSMTNAKLPNV 198
Query: 147 DLATSLEVLMLGRPNLPNHGFNLNG-SQSDNLT-----IPNKLILKRLRDLNTCLSIKIS 200
DL T+LEVL LGRPNLP H F L+G S S ++ +P LIL+RL+DLN +SIKI+
Sbjct: 199 DLVTALEVLSLGRPNLPTHNFKLSGVSNSMDMVDGMAKVPIGLILQRLKDLNLTVSIKIA 258
Query: 201 LMTIPSQLAKYEIKDGRIVFTVKDEFELQLSTIDQNSPLFFVNINLLFN----------- 249
LM IP L Y IK+GRI FTV +EFE+QLST+++ SPLFFV++ LLFN
Sbjct: 259 LMNIPKPLNSYHIKNGRIYFTVPNEFEIQLSTVNRQSPLFFVDLKLLFNTEAEQTVSAVT 318
Query: 250 --------------------ERLPLNLARLEKHINEILFKSTNPLCLVYQFLHKYILTLQ 289
LPLN RLEK INEIL KS +PL +Y FLHKY+LTLQ
Sbjct: 319 EATSTNGDSENNEENSSSNGNNLPLNKPRLEKLINEILLKSNDPLLSLYNFLHKYVLTLQ 378
Query: 290 MYMIHVELNALGLNGKYSGGHLVHNYDSKKQIITIKYWLQSKIANTCKCVVGMDKETESI 349
+YM+H E L GK+S +L+HNYDSKK IT++YWL K+ + K +G+ + TES+
Sbjct: 379 LYMVHREFLKLANGGKFSKSNLIHNYDSKKSTITVRYWLNGKMDSKGKITIGIQRTTESL 438
Query: 350 VLEWQNPDVNK-ETVTTRYHGLLNNIESIIDEITFNHAQMIRADLLRTDTFQEDNEDTTS 408
+L+W N ++ + + Y+ +++NIE I+DEI FNHA++IR++LL D FQED E+ S
Sbjct: 439 ILKWDNQSASRAKNMPVIYNNIVSNIEGILDEIMFNHARIIRSELLARDIFQEDEEN--S 496
Query: 409 TSLLFQIPTTCATVSQIQLKIDQVSGIFYFHNPSNLLLSYARQINQSSNTQDLITVLGRL 468
LLFQ+PTTC +++ IQLKID +SG FYF NP+ LL +YA +IN++ ++L +L +L
Sbjct: 497 DVLLFQLPTTCVSMAPIQLKIDLLSGQFYFRNPTPLLSNYASKINRAEGPEELARILQQL 556
Query: 469 KLDKVDSILRHMLDKTGWICSDVVRLKS-----------SIVPSTDSTFS---------- 507
KLDK+ +L M + TGW CS ++++ S+V D+ ++
Sbjct: 557 KLDKIIHVLTTMFENTGWSCSRIIKIDKPIRTQVNTGGESVVKKEDNKYAIAGNSTTNSD 616
Query: 508 ------KDIFVKLKDWPSNWFLVLTIISSTNTCIVEKRIGKILSVKGVWKLKYMDKKNVI 561
+D+F++L WP NW+L+L+IISS +C+VEKRIGKI+S +G W LKY+D NV+
Sbjct: 617 VSLLLQRDLFIRLPHWPLNWYLILSIISSKTSCVVEKRIGKIVSQRGKWNLKYLDNSNVM 676
Query: 562 TSKLDTMTYPKMLTLQISILNKIVNHMIIDSLNELKIKNKICTFTTEDSNILPPYIIRKD 621
T KL+++TY K++ LQ +ILN+I+NHM+IDSLN+L+I+NKIC+ + LP YII+
Sbjct: 677 TVKLESITYQKIMILQRTILNRIINHMLIDSLNQLEIRNKICSSEMINEQKLPQYIIQ-- 734
Query: 622 GKENTDNITVIALGLESFLEGSKALNTILESSMLLKIDYQKMDIELYGKFKTDNEMIRCQ 681
G DNI++I L LESFLEGSKALN+ILESSM L+IDY I LY KFK + MI+CQ
Sbjct: 735 GSNTNDNISIITLELESFLEGSKALNSILESSMFLRIDYSNSQIRLYAKFKRNTMMIQCQ 794
Query: 682 CDELSIKFLEEDSLSFFMSENFGNLNDIMLYLSKFRKKLTQLIALTDVMDTLHSNFQSMD 741
D+L I F++E+ L+F++ E+F NL I+ YL+KFR+KL QL+ LTDV++ LH NF+S +
Sbjct: 795 IDKLYIHFVQEEPLAFYLEESFTNLGIIVQYLTKFRQKLMQLVVLTDVVERLHKNFESEN 854
Query: 742 FRVVELRPNEIRFKYLPMKDSPDNEDCVIRIVTNQEKVEKLDIKLSEHNPQAMIQRFLDE 801
F+++ L+PNEI FKYL D D++DC I+I TN + ++ L ++LS NPQ +IQ FLD
Sbjct: 855 FKIIALQPNEISFKYLSNNDE-DDKDCTIKISTNDDSIKNLTVQLSPSNPQHIIQPFLDN 913
Query: 802 KEGFAHNFIFHYLQFTLPLFRASK-------EADYTSSSPSTVKMHLFMHSLQEFHFLYR 854
+ ++FIF YLQFT LF+A K + S S + +++ +H+L E+ +Y
Sbjct: 914 SK-MDYHFIFSYLQFTSSLFKALKVILNERGGKFHESGSQYSTMVNIGLHNLNEYQIVYY 972
Query: 855 NHKVGGELSFIIQLRSVVRTRHQENTQYFVRFAQDYXXXXXXXXXXXXKAIAEIQKNAFS 914
N + G +++ I+L++V+ ++ Q+ + FA +A I + +
Sbjct: 973 NPQAGTKITICIELKTVLH-NGRDKIQFHIHFAD----------------VAHITTKSPA 1015
Query: 915 LALLKEQNSNXXXXXXXXXXXXXXXXXXXXXXXNKLLDLQDSSPTNAAVDWSSIKCVRLG 974
++ + + +L + P NA+ +RLG
Sbjct: 1016 YPMMHQVRNQ-----------------VFMLDTKRLGTPESVKPANAS------HAIRLG 1052
Query: 975 SALACSHDQILPLLLQFH 992
+ +AC +I P+L++ H
Sbjct: 1053 NGVACDPSEIEPILMEIH 1070
>7291979 [K] KOG1875 Thyroid hormone receptor-associated coactivator complex
component (TRAP170)
Length = 1521
Score = 82.4 bits (202), Expect = 3e-15
Identities = 94/397 (23%), Positives = 168/397 (41%), Gaps = 26/397 (6%)
Query: 69 KTPFEKKLELLNMILFLRNQFLKLYVLVKWAKTLKQNNFHSLIDLLNWFRNANMQ-VNNC 127
KT E+K+E+ N R+ F +L LVKW ++ + + S I +++ NM V
Sbjct: 52 KTDMERKVEIYNYAARTRHLFTRLNALVKWGNSVSKVDKSSQI--MSFLDKQNMLFVETA 109
Query: 128 TMALKQILGTMAGAKLPNPDLATSLEVLMLGRPNLPNHGFNLNGSQSDNLTIPNKLILKR 187
M + T+ A+LPN + ++EVL G N +D +T K +
Sbjct: 110 DMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPADAITPAEKR--QT 167
Query: 188 LRDLNTCLSIKISLMTIPSQLAKYEIKDGRIVFTVKDEFELQLSTIDQNS--PLFFVNIN 245
L LN + ++ + Q+ ++ I++GR+ F VK EF + L+ + N P ++I+
Sbjct: 168 LLRLNQVIQHRLVTGKLLPQMREFRIRNGRVTFEVKHEFSVSLTVMGDNPTVPWRLLDID 227
Query: 246 LLFNER---------LPLNLARLEKHINEILFKSTNPLCLVYQFLHKYILTLQMYMIHVE 296
+L ++ PL + + + I L ++ N L VY LH + +LQ+ +++ +
Sbjct: 228 VLVEDKETGDGKSLVHPLQVNYIHQLIQARLVENPNALSEVYNCLHYFCQSLQLEVLYTQ 287
Query: 297 LNALGLNGKYSGGHLVHNYDSKKQIITIKYWLQSKIANTCKCVVGMD-KETESIVLEWQN 355
L V Y + +T+ YW K + V D E +
Sbjct: 288 TLRLNYERLDDNNITVEEYVPGVK-LTVSYWRDLKSELGYRLTVQSDPSEIGRPLAVVHV 346
Query: 356 PDVN-KETVTTRYHGLLN---NIESIIDEITFNHAQMIRADL-LRTDTFQED---NEDTT 407
P + KE+ + + ++E +I + + +DL L F +D N T
Sbjct: 347 PSLGAKESAEVADRAVRSEHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGT 406
Query: 408 STSLLFQIPTTCATVSQIQLKIDQVSGIFYFHNPSNL 444
L + + C QI + ID +G+F H P +L
Sbjct: 407 PAILTVPVLSPCLRAEQIHITIDTHTGMFRCHVPKHL 443
>CE20551 [K] KOG1875 Thyroid hormone receptor-associated coactivator complex
component (TRAP170)
Length = 1391
Score = 67.8 bits (164), Expect = 8e-11
Identities = 64/290 (22%), Positives = 127/290 (43%), Gaps = 46/290 (15%)
Query: 76 LELLNMILFLRNQFLKLYVLVKWAKTLKQNN------------------FHSLIDLLNWF 117
+ L++ R+QFLKL LVKW + K+ + F S+ LL+
Sbjct: 1 MSLVHFAHATRSQFLKLVALVKWIRISKRMDVCYVSLIRSISIEKKTLIFQSIDYLLDL- 59
Query: 118 RNANMQVNNCTMALKQILGTMAGAKLPNPDLATSLEVLMLGRPNLPNHGFNLNGSQSDNL 177
+ ++ + G + A+LP +A +++VL+LG +N S+
Sbjct: 60 -QSQYFIDTADRLVAMTRGDLELARLPEYHIAPAIDVLVLGT-------YNRMPSKIKEA 111
Query: 178 TIPNKLILKRLRDL-----NTCLSIKISLMT--IPSQLAKYEIKDGRIVFTVKDEFELQL 230
IP I R + L N + ++S ++ IP + + I +G V EFE+++
Sbjct: 112 FIPPAKITPREQKLVTSRLNQLIESRLSRLSSGIPPNIKEIHINNGLATLLVPGEFEIKI 171
Query: 231 STIDQN--SPLFFVNINLLFNERL---------PLNLARLEKHINEILFKSTNPLCLVYQ 279
+ + + + +NI +L + PL L +L + + S NP+ +
Sbjct: 172 TLLGETEMTKWTLLNIKILVEDYELGMGLPLVHPLQLNQLHGVLQSRMNVSLNPIKEAFS 231
Query: 280 FLHKYILTLQMYMIHVELNALGLNGKYSGGHLVHNYDSKKQIITIKYWLQ 329
FLH + ++LQ+ ++ + + L G+ + YD K++++ + YW++
Sbjct: 232 FLHSFCVSLQLDVLFCQTSRLAA-GRLRDNITIEKYDPKERVLVVGYWVK 280
>CE20550 [K] KOG1875 Thyroid hormone receptor-associated coactivator complex
component (TRAP170)
Length = 1385
Score = 67.8 bits (164), Expect = 8e-11
Identities = 64/290 (22%), Positives = 127/290 (43%), Gaps = 46/290 (15%)
Query: 76 LELLNMILFLRNQFLKLYVLVKWAKTLKQNN------------------FHSLIDLLNWF 117
+ L++ R+QFLKL LVKW + K+ + F S+ LL+
Sbjct: 1 MSLVHFAHATRSQFLKLVALVKWIRISKRMDVCYVSLIRSISIEKKTLIFQSIDYLLDL- 59
Query: 118 RNANMQVNNCTMALKQILGTMAGAKLPNPDLATSLEVLMLGRPNLPNHGFNLNGSQSDNL 177
+ ++ + G + A+LP +A +++VL+LG +N S+
Sbjct: 60 -QSQYFIDTADRLVAMTRGDLELARLPEYHIAPAIDVLVLGT-------YNRMPSKIKEA 111
Query: 178 TIPNKLILKRLRDL-----NTCLSIKISLMT--IPSQLAKYEIKDGRIVFTVKDEFELQL 230
IP I R + L N + ++S ++ IP + + I +G V EFE+++
Sbjct: 112 FIPPAKITPREQKLVTSRLNQLIESRLSRLSSGIPPNIKEIHINNGLATLLVPGEFEIKI 171
Query: 231 STIDQN--SPLFFVNINLLFNERL---------PLNLARLEKHINEILFKSTNPLCLVYQ 279
+ + + + +NI +L + PL L +L + + S NP+ +
Sbjct: 172 TLLGETEMTKWTLLNIKILVEDYELGMGLPLVHPLQLNQLHGVLQSRMNVSLNPIKEAFS 231
Query: 280 FLHKYILTLQMYMIHVELNALGLNGKYSGGHLVHNYDSKKQIITIKYWLQ 329
FLH + ++LQ+ ++ + + L G+ + YD K++++ + YW++
Sbjct: 232 FLHSFCVSLQLDVLFCQTSRLAA-GRLRDNITIEKYDPKERVLVVGYWVK 280
>Hs4758102 [K] KOG1875 Thyroid hormone receptor-associated coactivator complex
component (TRAP170)
Length = 1454
Score = 66.2 bits (160), Expect = 2e-10
Identities = 88/402 (21%), Positives = 171/402 (41%), Gaps = 48/402 (11%)
Query: 69 KTPFEKKLELLNMILFLRNQFLKLYVLVKWA----KTLKQNNFHSLIDLLNWFRNANMQV 124
K+ E+K+E++ R F++L LVKWA K K S +D + A + V
Sbjct: 76 KSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLD-----QQAILFV 130
Query: 125 NNCTMALKQILGTMAGAKLPNPDLATSLEVLMLGR-PNLPNHGFNLNGSQSDNLTIPNKL 183
+ + A+LP+ + +++VL G P LP D + P+ +
Sbjct: 131 DTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPT-------CIRDKIIPPDPI 183
Query: 184 --ILKR--LRDLNTCLSIKISLMTIPSQLAKYEIKDGRIVFTVKDEFELQLSTI--DQNS 237
I K+ L LN L ++ +P QLA + +GR+ F V+ EFE L+ + D +
Sbjct: 184 TKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDV 243
Query: 238 PLFFVNINLLFNER---------LPLNLARLEKHINEILFKSTNPLCLVYQFLHKYILTL 288
P + + +L ++ + ++ + + + LF PL +Y LH + L+L
Sbjct: 244 PWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSL 303
Query: 289 QMYMIHVELNALGLNGKYSGGHLVHNYDSKKQIITIKYWLQSKI------ANTCKCVVGM 342
Q+ ++H + L + ++ V Y + K +++ W Q + A+ K + +
Sbjct: 304 QLEVLHSQTLML-IRERWGDLVQVERYHAGK-CLSLSVWNQQVLGRKTGTASVHKVTIKI 361
Query: 343 DKETESIVLE-WQNPDV----NKETVTTRYHGLLNNIESIIDEI---TFNHAQMIRADLL 394
D+ S L+ + +P + +K L+ + +ID + Q ++A L
Sbjct: 362 DENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILR 421
Query: 395 RTDTFQEDNEDTTSTSLLFQIPTTCATVSQIQLKIDQVSGIF 436
+ + + +T +L+ I C + + +D SG+F
Sbjct: 422 GFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMF 463
>At3g04740 [K] KOG1875 Thyroid hormone receptor-associated coactivator complex
component (TRAP170)
Length = 1703
Score = 55.5 bits (132), Expect = 4e-07
Identities = 56/250 (22%), Positives = 112/250 (44%), Gaps = 30/250 (12%)
Query: 73 EKKLELLNMILFLRNQFLKLYVLVKWAKTLKQNNFHSLIDLLNWFRNANMQVNNCTMALK 132
EKK+ LL + + + L+L L KW K + L+N+F++ ++ +
Sbjct: 42 EKKVSLLKYVAKTQQRMLRLNALAKWCKQ---------VPLINYFQDLGSTLSAHDICFT 92
Query: 133 QILGT-------MAGAKLPNPDLATSLEVLMLGRPNLPNHGFNLNGSQSDNLTIPNKLIL 185
Q + + A+ P D+ +++E+L+ G + G QS ++
Sbjct: 93 QAADSLFFMHEGLQQARAPVYDVPSAVEILLTGSYQRLPKCLDDVGMQS---SLDEHQQK 149
Query: 186 KRLRDLNTCLSIKISLMTIPSQLAKYEIKDGRIVFTVKDEFELQLSTIDQNSPLF---FV 242
LR L + K+ +T+P ++ + +I G + +V EF++ L T+ L +
Sbjct: 150 PALRKLEVLVRSKLLEITLPKEITEVKISKGTVTLSVDGEFKV-LVTLGYRGHLSMWRIL 208
Query: 243 NINLLFNERL-PLNLARLEKHI-----NEILFKSTNPLCLVYQFLHKYILTLQMYMIHVE 296
+++LL ER P+ L +HI + + NP ++Y LH+ + + M + +
Sbjct: 209 HLDLLVGERSGPIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQ 268
Query: 297 LNALGLNGKY 306
+ AL L G++
Sbjct: 269 VRAL-LQGRW 277
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.136 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,910,390
Number of Sequences: 60738
Number of extensions: 2258760
Number of successful extensions: 5534
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 5507
Number of HSP's gapped (non-prelim): 7
length of query: 998
length of database: 30,389,216
effective HSP length: 116
effective length of query: 882
effective length of database: 23,343,608
effective search space: 20589062256
effective search space used: 20589062256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)