ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV1490 good Q KOG1208 Secondary metabolites biosynthesis, transport and catabolism Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV1490 506707 505829 -293
(293 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL107w [Q] KOG1208 Dehydrogenases with different specificities ... 258 7e-69
7290709 [Q] KOG1208 Dehydrogenases with different specificities ... 64 3e-10
Hs21553325 [Q] KOG1208 Dehydrogenases with different specificiti... 63 6e-10
CE27908 [Q] KOG1208 Dehydrogenases with different specificities ... 62 1e-09
Hs10190746 [Q] KOG1208 Dehydrogenases with different specificiti... 62 1e-09
At2g37540 [Q] KOG1208 Dehydrogenases with different specificitie... 60 5e-09
CE01219 [Q] KOG1208 Dehydrogenases with different specificities ... 57 2e-08
CE28291 [Q] KOG1208 Dehydrogenases with different specificities ... 57 3e-08
7304180 [Q] KOG1208 Dehydrogenases with different specificities ... 57 3e-08
At4g11410 [Q] KOG1208 Dehydrogenases with different specificitie... 56 5e-08
SPCC736.13 [Q] KOG1208 Dehydrogenases with different specificiti... 55 1e-07
At5g50130 [Q] KOG1208 Dehydrogenases with different specificitie... 55 2e-07
Hs18582884 [Q] KOG1208 Dehydrogenases with different specificiti... 54 2e-07
CE27376 [Q] KOG1208 Dehydrogenases with different specificities ... 54 2e-07
CE20634 [Q] KOG1208 Dehydrogenases with different specificities ... 53 6e-07
Hs20070272 [Q] KOG1208 Dehydrogenases with different specificiti... 52 8e-07
7304177 [Q] KOG1208 Dehydrogenases with different specificities ... 52 1e-06
7304181 [Q] KOG1208 Dehydrogenases with different specificities ... 50 3e-06
7304178 [Q] KOG1208 Dehydrogenases with different specificities ... 50 3e-06
SPAC19A8.06 [Q] KOG1208 Dehydrogenases with different specificit... 49 7e-06
7300379 [Q] KOG1208 Dehydrogenases with different specificities ... 49 7e-06
>YKL107w [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 309
Score = 258 bits (659), Expect = 7e-69
Identities = 136/292 (46%), Positives = 200/292 (67%), Gaps = 8/292 (2%)
Query: 2 KTNPDIVYTKAQKLIELNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFRDENV 61
K +P + + + + + +++ VAI+GGTGG+GR ++R LAQ+ A+V VVG+TFRDE++
Sbjct: 4 KKDPTVSWER-KNINDIDFSRFNVAIIGGTGGLGRAISRELAQRNARVTVVGQTFRDEDL 62
Query: 62 EG-IEFIQADLGLVSEASRVA--ELLPAEKLDLLIFTTGVLAPPARRETSEGLEEDLAVS 118
+ I F++ADL LVSE R++ + +P E+L LIFTTG+ A R+ TSEGLE+D+AVS
Sbjct: 63 KDKINFVKADLSLVSECKRISHSDEIPYEELTHLIFTTGIFASRQRQATSEGLEKDMAVS 122
Query: 119 YISRLVMMNHLVPRLKEHGEKK---PRVFVMGFPGDNYMGDYRDLNSEES-YGAISTHMK 174
Y+SR ++ + + RL KK P+VF+ GFPG+ +GD DLNS+E Y A +THM
Sbjct: 123 YLSRYIIFHDVAKRLGISRTKKDDLPKVFIAGFPGNGQVGDPDDLNSDEKKYSAYATHMN 182
Query: 175 TVAGNEALVLDFKNRFATVNFYGLNPGLIRTNIRDNYLGKDTWKSRVVEWFIGMTNQTAE 234
TVA NE+LV+D K+R+ ++ +GLNPGLI+TNIR+N LG DT+ SR+ EW I T Q+AE
Sbjct: 183 TVAANESLVIDAKDRYTNIDTFGLNPGLIKTNIRNNLLGSDTYLSRITEWIISWTCQSAE 242
Query: 235 QYAEKLGPLLVAPELETHSGAMFDKNANPILPSKDFTDDYARNYIKASEELL 286
YA+ + L+ +P +E+ SG MF + ILPS T D +++ SE L+
Sbjct: 243 TYAKTICTLIASPAIESRSGTMFSNKGDAILPSPGLTKDVVEKFMENSELLV 294
>7290709 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 406
Score = 63.9 bits (154), Expect = 3e-10
Identities = 71/269 (26%), Positives = 120/269 (44%), Gaps = 32/269 (11%)
Query: 9 YTKAQKLIELNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFRDENVEGIEFIQ 68
Y KA ++ D K V + G GIG+E LA++GA+V + R ++ +
Sbjct: 66 YRKANRI-----DGKVVIVTGCNTGIGKETVLELAKRGARVYMACRDPGRCEAARLDIMD 120
Query: 69 -----------ADLGLVSEASRVAELLPAE--KLDLLIFTTGVLAPPARRETSEGLEEDL 115
DLG + E AE +LD+LI GV+A P R T++G E+
Sbjct: 121 RSRNQQLFNRTLDLGSLQSVRNFVERFKAEESRLDILINNAGVMACP-RTLTADGFEQQF 179
Query: 116 AVSYISRLVMMNHLVPRLKEHGEKKPRVFVMGFPGDNYMG--DYRDLNSEESY----GAI 169
V+++ ++ N L+ RLK P V+ + G + DL SE++Y GA
Sbjct: 180 GVNHLGHFLLTNLLLDRLK---HSSPSRIVVVSSAAHLFGRINREDLMSEKNYSKFFGAY 236
Query: 170 S-THMKTVAGNEALVLDFKNRFATVNFYGLNPGLIRTNIRDNYLGKDTWKSRVVEWFIGM 228
S + + + L K+ TVN +PG++RT I ++ G K+ + + +
Sbjct: 237 SQSKLANILFTLKLSTILKDTGVTVNC--CHPGVVRTEINRHFSGPGWMKTALQKGSLYF 294
Query: 229 TNQTAEQYAEKLGPLLVAPELETHSGAMF 257
+T + A+ L + P+LE +G +
Sbjct: 295 F-KTPKAGAQTQLRLALDPQLEGSTGGYY 322
>Hs21553325 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 330
Score = 62.8 bits (151), Expect = 6e-10
Identities = 65/254 (25%), Positives = 112/254 (43%), Gaps = 31/254 (12%)
Query: 25 VAIV-GGTGGIGRELARVLAQKGAKVIVVGRT----------FRDENV-EGIEFIQADLG 72
VAIV GGT GIG A+ LA+ G VI+ G ++E + + +EF+ DL
Sbjct: 45 VAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLA 104
Query: 73 LVSEASRVAELLPAEKLDL--LIFTTGVLAPPARRETSEGLEEDLAVSYISRLVMMNHLV 130
++ + + +K+ L LI GV+ P +R+T +G EE ++Y+ ++ N L+
Sbjct: 105 SMTSIRQFVQKFKMKKIPLHVLINNAGVMMVP-QRKTRDGFEEHFGLNYLGHFLLTNLLL 163
Query: 131 PRLKEHGEKKPRVFVMGFPGDNYMGDYRDLNSEESYGAISTHMKTVAGNEALV------- 183
LKE G V+ + +++ +S S H ALV
Sbjct: 164 DTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQ 223
Query: 184 --LDFKNRFATVNFYGLNPGLIRTNIRDNYLGKDTWKSRVVEWFIG-MTNQTAEQYAEKL 240
L + T N ++PG++ T++ + W +R+ + +G + +T ++ A
Sbjct: 224 RLLAAEGSHVTANV--VDPGVVNTDLYKHVF----WATRLAKKLLGWLLFKTPDEGAWTS 277
Query: 241 GPLLVAPELETHSG 254
V PELE G
Sbjct: 278 IYAAVTPELEGVGG 291
>CE27908 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 319
Score = 62.0 bits (149), Expect = 1e-09
Identities = 40/140 (28%), Positives = 70/140 (49%), Gaps = 15/140 (10%)
Query: 10 TKAQKLIE-LNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFRDENVE------ 62
T A ++++ ++L K AI G T GIG E A+ L KGA V+++ R +
Sbjct: 15 TNALEVLDGIDLSGKTFAITGTTSGIGVETAKALILKGAHVVMINRNYTASEASKKSLLI 74
Query: 63 -----GIEFIQADLGLVSEASRVAELLPAEKLDL--LIFTTGVLAPPARRETSEGLEEDL 115
I+ +Q DL +S + A+ +K L LI GV P+ + TS+G E
Sbjct: 75 ETPNAQIDIVQCDLNSLSSVKKAADEYLEQKWPLHGLILNAGVFG-PSEKTTSDGFEAHF 133
Query: 116 AVSYISRLVMMNHLVPRLKE 135
+++++ +++ L+P L+E
Sbjct: 134 GINHLAHFILIKELLPVLRE 153
>Hs10190746 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 336
Score = 61.6 bits (148), Expect = 1e-09
Identities = 84/307 (27%), Positives = 129/307 (41%), Gaps = 47/307 (15%)
Query: 20 LDNKYVAIVGGTGGIGRELARVLAQKGAKVIV-----------VGRTFR----------D 58
+ K V I G G+GR A L + GA+VI+ G+ R +
Sbjct: 41 MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPE 100
Query: 59 ENVEGI-EFIQADLGLVSEASRVA---ELLPAE-KLDLLIFTTGVLAPPARRETSEGLEE 113
V G+ E I +L L S S A E+L E +LD+LI G+ P + T +G E
Sbjct: 101 PGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMK-TEDGFEM 159
Query: 114 DLAVSYISRLVMMNHLVPRLKEHGEKKPRVFVMGFPGDNYMGD--YRDLNSEESYGAIST 171
V+++ ++ N L+ LK R+ V+ Y GD + DLNSE+SY
Sbjct: 160 QFGVNHLGHFLLTNLLLGLLKSSAPS--RIVVVSSKLYKY-GDINFDDLNSEQSYNKSFC 216
Query: 172 HMKTVAGNEALVLDFKNRF----ATVNFYGLNPGLIRTNIRDNYLGKDTWKSRVVEWFIG 227
+ ++ N + R TVN L+PG++RTN LG+ +V+
Sbjct: 217 YSRSKLANILFTRELARRLEGTNVTVNV--LHPGIVRTN-----LGRHIHIPLLVKPLFN 269
Query: 228 MTN----QTAEQYAEKLGPLLVAPELETHSGAMFDKNANPILPSKDFTDDYARNYIKASE 283
+ + +T + A+ L +PE+E SG F L K + AR SE
Sbjct: 270 LVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISE 329
Query: 284 ELLANLK 290
++ LK
Sbjct: 330 VMVGLLK 336
>At2g37540 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 321
Score = 59.7 bits (143), Expect = 5e-09
Identities = 66/273 (24%), Positives = 118/273 (43%), Gaps = 34/273 (12%)
Query: 27 IVGGTGGIGRELARVLAQKGAKVIVVGRTFRDENVE-----------GIEFIQADLGLV- 74
I GGT GIG E ARVLA +GA VI+ R + N ++++Q D+ +
Sbjct: 38 ITGGTSGIGLEAARVLAMRGAHVIIAARNPKAANESKEMILQMNPNARVDYLQIDVSSIK 97
Query: 75 SEASRVAELLPAE-KLDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRLVMMNHLVPRL 133
S S V + L L++LI GV+ P + T +G+E A ++I ++ N L+ ++
Sbjct: 98 SVRSFVDQFLALNVPLNILINNAGVMFCPFKL-TEDGIESQFATNHIGHFLLTNLLLDKM 156
Query: 134 KEHGEK---KPRVFVMGFPGDNY----------MGDYRDLNSEESYGAISTHMKTVAGNE 180
K + + R+ + Y + D + +YG + + + +
Sbjct: 157 KSTARESGVQGRIVNLSSIAHTYTYSEGIKFQGINDPAGYSERRAYG--QSKLSNLLHSN 214
Query: 181 ALVLDFKNRFATVNFYGLNPGLIRTNIRDNYLGKDTWKSRVVEWFIGMTNQTAEQYAEKL 240
AL + + ++PGL+ TN+ Y G + +V + + Q A
Sbjct: 215 ALSRRLQEEGVNITINSVHPGLVTTNL-FRYSG---FSMKVFRAMTFLFWKNIPQGAATT 270
Query: 241 GPLLVAPELETHSGAMFDKNANPILPSKDFTDD 273
+ + P+LE +G F + N + PSK T++
Sbjct: 271 CYVALHPDLEGVTGKYFG-DCNIVAPSKFATNN 302
>CE01219 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 329
Score = 57.4 bits (137), Expect = 2e-08
Identities = 37/131 (28%), Positives = 65/131 (49%), Gaps = 14/131 (10%)
Query: 18 LNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFRDE-----------NVEGIEF 66
+NL K + G T GIG E AR L+ GA V+++ R + N I+
Sbjct: 24 VNLAGKTFVVTGTTSGIGIETARSLSLNGAHVVMLNRNLEESEKLKKKIVEEMNDAEIDI 83
Query: 67 IQADLGLVSEASRVAELLPAEK--LDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRLV 124
I+ DL + + AE+ ++K + LI GV A + T +GLE A++++S +
Sbjct: 84 IECDLNSLHSVKKAAEVYISKKWSIHCLILNAGVFG-TASKTTVDGLESHFAINHLSHFL 142
Query: 125 MMNHLVPRLKE 135
++ L+P +++
Sbjct: 143 LIQELLPIVRQ 153
>CE28291 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 357
Score = 57.0 bits (136), Expect = 3e-08
Identities = 42/134 (31%), Positives = 66/134 (48%), Gaps = 14/134 (10%)
Query: 15 LIELNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFRD-----ENVE------G 63
L E++L K AI G T GIG E AR LA KGA V++ R + + +E
Sbjct: 29 LKEIDLSGKTYAITGTTSGIGIETARALALKGAHVVMFNRNIVESEKLKKRIEEEKPDVK 88
Query: 64 IEFIQADLGLVSEASRVAELLPAEKLDL--LIFTTGVLAPPARRETSEGLEEDLAVSYIS 121
I+FI DL + A A+ ++ L LI GV AP + T + E V++++
Sbjct: 89 IDFISCDLNSLQSAKAAADEFLSKHWPLHGLILNAGVFAPTV-KFTFDNFESHFGVNHLA 147
Query: 122 RLVMMNHLVPRLKE 135
+ ++ L+P L++
Sbjct: 148 QFLLAKELLPALRQ 161
>7304180 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 327
Score = 57.0 bits (136), Expect = 3e-08
Identities = 70/288 (24%), Positives = 114/288 (39%), Gaps = 25/288 (8%)
Query: 23 KYVAIVGGTGGIGRELARVLAQKGAKVIVVGRT-----------FRDENVEGIEFIQADL 71
K + GG G+G+E LA++GA V + R ++ + + DL
Sbjct: 46 KVAIVTGGNTGLGKETVMELARRGATVYMACRNKEKVERARREIVKETGNSNVFSRECDL 105
Query: 72 GLVSEASRVAELLPAEK--LDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRLVMMNHL 129
+ + AE E+ L +LI GV P R T EG E L V++I ++ N L
Sbjct: 106 SSLDSIRKFAENFKKEQRVLHILINNAGVFWEP-HRLTKEGFEMHLGVNHIGHFLLTNLL 164
Query: 130 VPRLKEHGEKKPRVFVMGFPGDNYMGDYRDLNSEESYGAISTHMKTVAGNEALVLDFKNR 189
+ L+ + V V + D+NS + Y + ++ N + R
Sbjct: 165 LGVLERSAPSRV-VVVASRAHERGQIKVDDINSSDFYDEGVAYCQSKLANILFTRELAKR 223
Query: 190 F----ATVNFYGLNPGLIRTNIRDNYLGKDT-WKSRVVEWFIGMTNQTAEQYAEKLGPLL 244
TVN LNPG+ T I N + T + ++ + +T + A+
Sbjct: 224 LEGTGVTVN--ALNPGIADTEIARNMIFFQTKFAQTILRPLLWAVMKTPKNGAQTTLYAA 281
Query: 245 VAPELETHSGAMF-DKNANPILPSKDFTDDYARNYIKASEELLANLKL 291
+ P+LE SG F D P+ P+ DD ++ A E A + L
Sbjct: 282 LDPDLERVSGQYFSDCALAPVAPAA--LDDQMAQWLWAQSEKWAKIAL 327
>At4g11410 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 56.2 bits (134), Expect = 5e-08
Identities = 54/207 (26%), Positives = 94/207 (45%), Gaps = 29/207 (14%)
Query: 27 IVGGTGGIGRELARVLAQKGAKVIVV------GRTFRDENVEGIEFIQAD---LGLVSEA 77
+ G + GIG E RVLA +G V++ G RD+ ++ I + D L L S A
Sbjct: 34 VTGASSGIGEETTRVLALRGVHVVMAVRNTDSGNQVRDKILKEIPQAKIDVMKLDLSSMA 93
Query: 78 SRVAELLPAEKLD----LLIFTTGVLAPPARRETSEGLEEDLAVSYISRLVMMNHLVPRL 133
S + + LD LLI G++A P +S+ +E A +++ ++ N L+ R+
Sbjct: 94 SVRSFASEYQSLDLPLNLLINNAGIMACPFLL-SSDNIELQFATNHLGHFLLTNLLLERM 152
Query: 134 KE---HGEKKPRVFVMGFPGDNYMGDYRD------LNSEESYGAISTHMKTVAGN----E 180
K+ ++ R+ ++ G + YR+ +N E Y + + ++ GN
Sbjct: 153 KKTASESNREGRIVIVSSEGHRFA--YREGVQFDKINDEARYNTLQAYGQSKLGNILHAT 210
Query: 181 ALVLDFKNRFATVNFYGLNPGLIRTNI 207
L FK + + L+PG I TN+
Sbjct: 211 ELARLFKEQGVNITANSLHPGSIMTNL 237
>SPCC736.13 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 339
Score = 55.1 bits (131), Expect = 1e-07
Identities = 58/213 (27%), Positives = 90/213 (42%), Gaps = 25/213 (11%)
Query: 19 NLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRT----------FRDE-NVEGIEFI 67
+L K + G +GGIG A LA+KGAKV + GR DE I F+
Sbjct: 39 DLTGKVALVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQIHDEVRHSKIRFL 98
Query: 68 QADLGLVSEASRVAE--LLPAEKLDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRLVM 125
+ DL + AE + EKL +L+ G++ PP T +G E + +Y+S +
Sbjct: 99 RLDLLDFESVYQAAESFIAKEEKLHILVNNAGIMNPPFEL-TKDGYELQIQTNYLSHYLF 157
Query: 126 MNHLVPRLKEHGEK-KP------RVFVMGFPGDNYMGDY-RDLN-SEESYGAISTHMKTV 176
L+P L+ E+ +P V + + Y G Y DLN G + + ++
Sbjct: 158 TELLLPTLRRTAEECRPGDVRIVHVASIAYLQAPYSGIYFPDLNLPHVLLGTFARYGQSK 217
Query: 177 AGNEALVLDFKNRFATVNFY--GLNPGLIRTNI 207
+ R Y L+PG+IRT +
Sbjct: 218 YAQILYSIALAKRLEKYGIYSVSLHPGVIRTEL 250
>At5g50130 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/212 (25%), Positives = 92/212 (42%), Gaps = 39/212 (18%)
Query: 27 IVGGTGGIGRELARVLAQKGAKVIVVGRTFRD----------ENVEG-IEFIQADLGLVS 75
I GGT GIG E ARVLA++G +V++ R + EN E I + DL +S
Sbjct: 41 ITGGTSGIGAETARVLAKRGVRVVMAVRDMKKAEMVKERIIRENPEADIILFEIDLSSLS 100
Query: 76 EASRVAELLPAE--KLDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRLVMMNHLVPRL 133
+R ++ L++LI GV +P + E +E A +++ ++ L+ ++
Sbjct: 101 SVARFCSQFLSQDLPLNILINNAGVFSPNL-EFSEEKIELTFATNFLGHYLLTEMLIEKM 159
Query: 134 KEHGEK------------------KPRVFVMGFPGDNYMGDYRDLNSEESYGAISTHMKT 175
+ EK KP F FP + Y N +Y + + T
Sbjct: 160 IDTAEKSGIEGRIINLSSVIHNWVKPDCF--SFPKLLHPIRY---NGTRAYA--QSKLAT 212
Query: 176 VAGNEALVLDFKNRFATVNFYGLNPGLIRTNI 207
+ +AL K+R A V ++PG+++T I
Sbjct: 213 ILHAKALSKQLKDRNANVTINAVHPGIVKTGI 244
>Hs18582884 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 54.3 bits (129), Expect = 2e-07
Identities = 67/258 (25%), Positives = 108/258 (40%), Gaps = 28/258 (10%)
Query: 18 LNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFR-----------DENVEGIEF 66
+ L K V I G GIG+E AR LA +GA+V + R D +
Sbjct: 35 VQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLV 94
Query: 67 IQADLGLVSEASRVAE--LLPAEKLDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRLV 124
+ DL AE L ++L +LI GV+ P + T++G E L V+++ +
Sbjct: 95 RKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSK-TADGFETHLGVNHLGHFL 153
Query: 125 MMNHLVPRLKEHGEKKPRVFVMGFPGDNYMG--DYRDLNSEESYGAISTHMKTVAGNEAL 182
+ L+ RLK P V +++G + DL SE+ Y + + N
Sbjct: 154 LTYLLLERLK---VSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLF 210
Query: 183 VLDFKNRF--ATVNFYGLNPGLIRTN-IRDNYLGKDTWKSRVVEWFIGMTNQTAEQYAEK 239
+ R V Y ++PG++R+ +R + L W R+ F+ +TA + A+
Sbjct: 211 TRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLW--RLFSPFV----KTAREGAQT 264
Query: 240 LGPLLVAPELETHSGAMF 257
+A LE SG F
Sbjct: 265 SLHCALAEGLEPLSGKYF 282
>CE27376 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 54.3 bits (129), Expect = 2e-07
Identities = 66/284 (23%), Positives = 118/284 (41%), Gaps = 35/284 (12%)
Query: 25 VAIVGGTGGIGRELARVLAQKGAKVIVV-GRTFR------------DENVEGIEFIQADL 71
+ I G T GIG++ A LA +++ GRT + N I+++ D
Sbjct: 41 ILITGATDGIGKQTALDLAAHPDNFVIIHGRTEEKCIATKDWIGKENGNCSNIDYVAGDF 100
Query: 72 GLVSEASRVAELLPAE--KLDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRLVMMNHL 129
++ E + +AE + +L++L+ GVL P R ET +G+E V+Y++ ++ N L
Sbjct: 101 AVLKEVAIIAEEVERRFPELNVLLCNAGVLYP-RRLETKDGMESTFQVNYLAHYLLCNLL 159
Query: 130 VPRLKEHGEKKPRVFVMGFPGDNYMG-DYRDLNSEESYGAISTHMKTVAGNEALVLDFKN 188
+P L + + V V+G + D+ D+ + + Y + ++ +
Sbjct: 160 LPVLSHN---RSNVIVVGSVLHTWPSLDWADVMATKEYEKYLQYSRSKLMCHLMAFALHR 216
Query: 189 RFATVNFYGLNPGLIRTNIRDNYLGKD-----TWKSRVVEWF-IGMTNQTAEQYAEKLGP 242
R +N N+ LGK+ K R M+ + + A L
Sbjct: 217 R--------MNIARQHVNVNIIELGKEKEPNNNGKLRTTSALSSSMSTLSICRQAGNLAQ 268
Query: 243 LLVAPELETHSGAMFDKNANPILPSKDFTDDYARNYIKA-SEEL 285
L+ P LE SG D + + D TD+ + + A S+EL
Sbjct: 269 LIEGPCLEKISGKYLDPSGKQMRSGSDATDERLQERLWAYSKEL 312
>CE20634 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 398
Score = 52.8 bits (125), Expect = 6e-07
Identities = 38/165 (23%), Positives = 70/165 (42%), Gaps = 16/165 (9%)
Query: 18 LNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFRDENV-----------EGIEF 66
++L K AI G T G+G E AR KGA ++++ R + I+
Sbjct: 102 IDLSGKTYAITGTTSGVGTETARAFILKGAHIVMINRNYAASETLKQSLLCETPDARIDI 161
Query: 67 IQADLGLVSEASRVAELLPAEKLDL--LIFTTGVLAPPARRETSEGLEEDLAVSYISRLV 124
+Q DL ++ + AE +K L LI GVL + T++ E +++++ +
Sbjct: 162 VQCDLSSLASVKKTAEEYLTKKWPLHGLILNAGVLG-RKEKTTADRFEAHFGINHLAHFL 220
Query: 125 MMNHLVPRLKEHGEKKPRVFVMGFPGDNYMGDYRDLNSEESYGAI 169
++ L+P L+ R+ ++ + D EE G +
Sbjct: 221 LIKELLPVLRSSAPS--RIVILSSTLSKFTSINPDSKIEEKLGTL 263
>Hs20070272 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 318
Score = 52.4 bits (124), Expect = 8e-07
Identities = 63/259 (24%), Positives = 108/259 (41%), Gaps = 30/259 (11%)
Query: 18 LNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFRDENVEGIEFIQADLGLVSEA 77
+ L K V + G GIG+E A+ LAQ+GA+V + R + E IQ G
Sbjct: 37 VQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKE-IQTTTGNQQVL 95
Query: 78 SRVAEL-------------LPAEK-LDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRL 123
R +L L EK L +LI GV+ P + T++G E + V+++
Sbjct: 96 VRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSK-TADGFEMHIGVNHLGHF 154
Query: 124 VMMNHLVPRLKEHGEKKPRVFVMGFPGDNYMG--DYRDLNSEESYGAISTHMKTVAGNEA 181
++ + L+ +LK E P V +++G + +L E+ Y A + + N
Sbjct: 155 LLTHLLLEKLK---ESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANIL 211
Query: 182 LVLDFKNRF--ATVNFYGLNPGLIRTN-IRDNYLGKDTWKSRVVEWFIGMTNQTAEQYAE 238
+ R + V Y ++PG +++ +R + + W W +T +Q A+
Sbjct: 212 FTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMW------WLFSFFIKTPQQGAQ 265
Query: 239 KLGPLLVAPELETHSGAMF 257
+ LE SG F
Sbjct: 266 TSLHCALTEGLEILSGNHF 284
>7304177 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 300
Score = 51.6 bits (122), Expect = 1e-06
Identities = 65/278 (23%), Positives = 110/278 (39%), Gaps = 19/278 (6%)
Query: 23 KYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTF-----------RDENVEGIEFIQADL 71
K + G GIG+E +A++G V + R R+ N + I + DL
Sbjct: 15 KVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQNIFSRELDL 74
Query: 72 GLVSEASRVAELLPAE--KLDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRLVMMNHL 129
+ + A E KL +LI GV+ P R T +G E L V+++ ++ + L
Sbjct: 75 SSLESIRKFAAGFKKEQDKLHVLINNAGVMHCP-RTLTKDGFEMQLGVNHMGHFLLTHLL 133
Query: 130 VPRLKEHGEKKPRVFVMGFPGDNYMGDYRDLNSEESYGAISTHMKTVAGNEALVLDFKNR 189
+ LK+ + V V DLNSE+SY I + ++ N + R
Sbjct: 134 LDVLKKTAPSRI-VNVSSLVHTQGFIKTADLNSEKSYSRIGAYSQSKLANVLFTRELAKR 192
Query: 190 F--ATVNFYGLNPGLIRTNIRDNY-LGKDTWKSRVVEWFIGMTNQTAEQYAEKLGPLLVA 246
V L+PG + T + N+ K + +++ + + +T A+ +
Sbjct: 193 LEGTGVTTNSLHPGAVDTELSRNWKFLKHPFAQLLLKPLLWVLFKTPRNGAQTTLYAALD 252
Query: 247 PELETHSGAMFDKNANPILPSKDFTDDYARNYIKASEE 284
P L+ SG F + P S DD ++ A E
Sbjct: 253 PALKDVSGLYF-SDCQPKEVSAAAQDDKTGKFLWAESE 289
>7304181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 331
Score = 50.4 bits (119), Expect = 3e-06
Identities = 51/206 (24%), Positives = 82/206 (39%), Gaps = 17/206 (8%)
Query: 17 ELNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFRDENVEGIEFI--------- 67
E N K + G GIG+E R +A++G V + R + E +
Sbjct: 40 ETNETGKVFIVTGANTGIGKETVREIAKRGGTVYMACRNLKKCEEAREEIVLETKNKYVY 99
Query: 68 --QADLGLVSEASRVAELLPAEK--LDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRL 123
Q DL E+ L +LI GV+ P R TS+G+E L V+++
Sbjct: 100 CRQCDLASQESIRHFVAAFKREQEHLHVLINNAGVMRCP-RSLTSDGIELQLGVNHMGHF 158
Query: 124 VMMNHLVPRLKEHGEKKPRVFVMGFPGDNYMGDYRDLNSEESYGAISTHMKTVAGNEALV 183
++ N L+ LK+ + V V + DLNS++SY + ++ N
Sbjct: 159 LLTNLLLDLLKKSSPSR-IVNVSSLAHTRGEINTGDLNSDKSYDEGKAYSQSKLANVLFT 217
Query: 184 LDFKNRF--ATVNFYGLNPGLIRTNI 207
+ R V L+PG++ T I
Sbjct: 218 RELAKRLEGTNVTANALHPGVVDTEI 243
>7304178 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 50.4 bits (119), Expect = 3e-06
Identities = 73/280 (26%), Positives = 115/280 (41%), Gaps = 25/280 (8%)
Query: 25 VAIVGGTG-GIGRELARVLAQKGAKVIVVGRTFRD-----------ENVEGIEFIQADLG 72
VAIV G GIG+E LA++GA V + R + N + I Q DL
Sbjct: 16 VAIVTGCNQGIGKETVLELARRGATVYMACRDMKKCENARREIIKATNNQNIFARQLDLC 75
Query: 73 LVSEASRVAELLPAE--KLDLLIFTTGVLAPPARRETSEGLEEDLAVSYISRLVMMNHLV 130
+ A E KL +LI G++ P + T +G E + V+++ ++ L+
Sbjct: 76 SMKSIRNFAAGFKREQNKLHILINNAGIMDCP-KMLTEDGFEMQIGVNHMGHFLLTLLLL 134
Query: 131 PRLKEHGEKKPRVFVMGFPGDNYMGDYR-DLNSEESYGAISTHMKTVAGNEALVLDFKNR 189
LK RV V+ + R DLNSE+SY + ++ N + R
Sbjct: 135 DVLKSSAPS--RVVVLSSIAHRFGRIKRDDLNSEKSYDRKMAYCQSKLANVLFTRELAKR 192
Query: 190 FA----TVNFYGLNPGLIRTNIRDNYLGKDTWKSR-VVEWFIGMTNQTAEQYAEKLGPLL 244
+ TVN L+PG++ T + N +W + ++ I + +TA A+
Sbjct: 193 LSGTGVTVN--ALHPGVVNTELFRNTPFLGSWFGKLLIAPIIWIFIKTARNGAQTTLYAA 250
Query: 245 VAPELETHSGAMFDKNANPILPSKDFTDDYARNYIKASEE 284
+ P LE SG F + S DD A+ SE+
Sbjct: 251 LDPSLEKVSGRYFSDCKQKHVGSAAQYDDDAQFLWAESEK 290
>SPAC19A8.06 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 397
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/229 (24%), Positives = 101/229 (43%), Gaps = 45/229 (19%)
Query: 17 ELNLDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTFRDENVEGIEFI--------- 67
E ++ V + GG+ GIG+ + LA GA+V+++ RT D+ +++I
Sbjct: 70 ERKMNGMVVMVTGGSSGIGQVVVEKLASLGAQVVILLRTEPDQFT--VDYIMDLRKRTKN 127
Query: 68 ----------QADLGLVSEASRVAELLPAEKLDLLIFTTGVLAPP--ARRETSEGLEEDL 115
+ L + A++ + P +LD+++ +GVL PP R+ T EG+E
Sbjct: 128 QLIYTEVCDLSSMLSVRKFATKWIDCTPIRRLDMIVLCSGVLLPPFMDRQTTEEGVELQW 187
Query: 116 AVSYISRLVMMNHLVPRL-KEHGEKKPRVFVMGFPGDNYMG--DYRDLN-SEESYGAIST 171
A +++ ++ L P + + G ++ R+ V +G D+ DL+ S Y S
Sbjct: 188 ATNFLGPYQLLRILRPVIYGQPGHREVRI-VAATCSSYILGNIDFNDLDLSNHPYPRKSP 246
Query: 172 HMKTVAGNEALVL-----DFKNRF----------ATVNFYGLNPGLIRT 205
V GN L L DF+ + ++ NPG++RT
Sbjct: 247 W--KVVGNAKLALMTYLYDFQKKAEAHERPDKMPCNLHTIMANPGVVRT 293
>7300379 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 266
Score = 49.3 bits (116), Expect = 7e-06
Identities = 52/222 (23%), Positives = 91/222 (40%), Gaps = 40/222 (18%)
Query: 20 LDNKYVAIVGGTGGIGRELARVLAQKGAKVIVVGRTF----------------------- 56
+ + V + GG GIG E+A+ LA +G ++I+ R
Sbjct: 41 IKEQIVVVTGGNSGIGFEIAQALAGRGGRIILACRNLEAGKRAAAIIKRELGCRTPLNSL 100
Query: 57 -RDENVEGIEFIQA---DLGLVSEASRVAELLPA--EKLDLLIFTTGVLAPPARRETSEG 110
D+N E F++A DL + A L A E++D+L+ GV+ + T +G
Sbjct: 101 DEDDNPEDRYFVEARYLDLCSLRSVHHFAGQLMAEFERIDVLVNNAGVVFANTQMPTEDG 160
Query: 111 LEEDLAVSYISRLVMMNHLVPRLKEHGEKKPRVFVMGFPGDNYMGDYRDLNSEESYGAIS 170
E V+Y++ ++ + L+P L + E+ +FV D+ D + ++
Sbjct: 161 FERHSQVNYLAPFLLTHLLLPHL-QRSEQGRILFVSAHAHQGAKIDFDDPLNVGTWSVKF 219
Query: 171 THMKTVAGNEALVL--------DFKNRFATVNFYGLNPGLIR 204
+ A ++ VL + K TVN PGL+R
Sbjct: 220 HAREAFAHSKLCVLLATRWMARELKGTSVTVNC--CTPGLVR 259
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.136 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,497,945
Number of Sequences: 60738
Number of extensions: 747669
Number of successful extensions: 2086
Number of sequences better than 1.0e-05: 21
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2067
Number of HSP's gapped (non-prelim): 22
length of query: 293
length of database: 30,389,216
effective HSP length: 105
effective length of query: 188
effective length of database: 24,011,726
effective search space: 4514204488
effective search space used: 4514204488
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)