ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV1536 good Q KOG1208 Secondary metabolites biosynthesis, transport and catabolism Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV1536 527156 526167 -330
(330 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR246c [Q] KOG1208 Dehydrogenases with different specificities ... 426 e-119
SPCC736.13 [Q] KOG1208 Dehydrogenases with different specificiti... 148 1e-35
Hs20070272 [Q] KOG1208 Dehydrogenases with different specificiti... 122 7e-28
Hs21553325 [Q] KOG1208 Dehydrogenases with different specificiti... 120 4e-27
Hs10190746 [Q] KOG1208 Dehydrogenases with different specificiti... 119 5e-27
7304178 [Q] KOG1208 Dehydrogenases with different specificities ... 115 9e-26
7304177 [Q] KOG1208 Dehydrogenases with different specificities ... 115 9e-26
At2g37540 [Q] KOG1208 Dehydrogenases with different specificitie... 112 7e-25
7304180 [Q] KOG1208 Dehydrogenases with different specificities ... 111 2e-24
7304181 [Q] KOG1208 Dehydrogenases with different specificities ... 109 6e-24
Hs18582884 [Q] KOG1208 Dehydrogenases with different specificiti... 108 1e-23
At4g11410 [Q] KOG1208 Dehydrogenases with different specificitie... 107 2e-23
7297326 [Q] KOG1208 Dehydrogenases with different specificities ... 106 5e-23
7290709 [Q] KOG1208 Dehydrogenases with different specificities ... 106 5e-23
Hs7706523 [Q] KOG1208 Dehydrogenases with different specificitie... 102 8e-22
7304176 [Q] KOG1208 Dehydrogenases with different specificities ... 102 8e-22
At5g02540 [Q] KOG1208 Dehydrogenases with different specificitie... 97 4e-20
7300379 [Q] KOG1208 Dehydrogenases with different specificities ... 95 1e-19
7302393 [Q] KOG1208 Dehydrogenases with different specificities ... 94 2e-19
Hs13699258 [Q] KOG1208 Dehydrogenases with different specificiti... 93 6e-19
Hs19923931 [Q] KOG1208 Dehydrogenases with different specificiti... 89 1e-17
CE08181 [Q] KOG1208 Dehydrogenases with different specificities ... 87 3e-17
At5g50130 [Q] KOG1208 Dehydrogenases with different specificitie... 86 1e-16
At5g53090 [Q] KOG1208 Dehydrogenases with different specificitie... 84 2e-16
At5g53100 [Q] KOG1208 Dehydrogenases with different specificitie... 82 1e-15
CE07803 [Q] KOG1208 Dehydrogenases with different specificities ... 82 1e-15
At4g27760 [Q] KOG1208 Dehydrogenases with different specificitie... 82 1e-15
At4g23430 [Q] KOG1208 Dehydrogenases with different specificitie... 82 1e-15
7300387 [Q] KOG1208 Dehydrogenases with different specificities ... 80 3e-15
At5g15940 [Q] KOG1208 Dehydrogenases with different specificitie... 79 9e-15
CE20634 [Q] KOG1208 Dehydrogenases with different specificities ... 78 2e-14
Hs21389583 [Q] KOG1208 Dehydrogenases with different specificiti... 73 5e-13
CE16253 [Q] KOG1208 Dehydrogenases with different specificities ... 71 2e-12
At1g64590 [Q] KOG1208 Dehydrogenases with different specificitie... 71 2e-12
CE27908 [Q] KOG1208 Dehydrogenases with different specificities ... 70 6e-12
At4g24050 [Q] KOG1208 Dehydrogenases with different specificitie... 70 6e-12
Hs20149619 [Q] KOG1205 Predicted dehydrogenase 69 9e-12
At4g09750 [Q] KOG1208 Dehydrogenases with different specificitie... 69 9e-12
CE01219 [Q] KOG1208 Dehydrogenases with different specificities ... 68 2e-11
CE28291 [Q] KOG1208 Dehydrogenases with different specificities ... 68 2e-11
CE21092 [R] KOG0725 Reductases with broad range of substrate spe... 65 1e-10
Hs13375997 [Q] KOG1208 Dehydrogenases with different specificiti... 62 1e-09
At5g61830 [Q] KOG1208 Dehydrogenases with different specificitie... 62 2e-09
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 61 2e-09
CE21095 [R] KOG0725 Reductases with broad range of substrate spe... 61 2e-09
Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 61 3e-09
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 61 3e-09
Hs4502599 [Q] KOG1208 Dehydrogenases with different specificitie... 60 4e-09
7292613 [Q] KOG1205 Predicted dehydrogenase 59 1e-08
CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 58 2e-08
7295621 [Q] KOG1205 Predicted dehydrogenase 58 2e-08
CE15574 [R] KOG0725 Reductases with broad range of substrate spe... 57 3e-08
CE06649 [R] KOG0725 Reductases with broad range of substrate spe... 57 4e-08
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 56 6e-08
Hs7706318 [Q] KOG1205 Predicted dehydrogenase 55 1e-07
CE20000 [Q] KOG1208 Dehydrogenases with different specificities ... 55 1e-07
7301818 [Q] KOG1205 Predicted dehydrogenase 55 1e-07
CE27376 [Q] KOG1208 Dehydrogenases with different specificities ... 55 1e-07
CE21093 [R] KOG0725 Reductases with broad range of substrate spe... 55 1e-07
CE27260 [R] KOG0725 Reductases with broad range of substrate spe... 55 2e-07
CE27259 [R] KOG0725 Reductases with broad range of substrate spe... 55 2e-07
At5g04070 [Q] KOG1208 Dehydrogenases with different specificitie... 55 2e-07
CE07544 [Q] KOG1205 Predicted dehydrogenase 54 2e-07
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 54 2e-07
CE26808_2 [R] KOG0725 Reductases with broad range of substrate s... 54 2e-07
Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 54 4e-07
At3g59710 [Q] KOG1208 Dehydrogenases with different specificitie... 54 4e-07
At1g03630 [Q] KOG1208 Dehydrogenases with different specificitie... 54 4e-07
HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 53 5e-07
Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 53 5e-07
At1g62610 [R] KOG0725 Reductases with broad range of substrate s... 53 5e-07
CE20922 [Q] KOG1208 Dehydrogenases with different specificities ... 53 7e-07
CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase 53 7e-07
At3g61220 [Q] KOG1208 Dehydrogenases with different specificitie... 53 7e-07
7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 53 7e-07
7295622 [Q] KOG1205 Predicted dehydrogenase 53 7e-07
CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase 52 9e-07
7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 52 1e-06
7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 52 1e-06
At4g27440 [Q] KOG1208 Dehydrogenases with different specificitie... 52 2e-06
Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 51 2e-06
Hs4502601 [Q] KOG1208 Dehydrogenases with different specificitie... 51 3e-06
SPAC19A8.06 [Q] KOG1208 Dehydrogenases with different specificit... 50 3e-06
Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 50 3e-06
CE12990 [R] KOG0725 Reductases with broad range of substrate spe... 50 3e-06
CE09505 [R] KOG1611 Predicted short chain-type dehydrogenase 50 3e-06
At3g26770 [R] KOG0725 Reductases with broad range of substrate s... 50 3e-06
CE14538 [R] KOG0725 Reductases with broad range of substrate spe... 50 5e-06
CE03951 [R] KOG0725 Reductases with broad range of substrate spe... 50 5e-06
At1g63380 [R] KOG0725 Reductases with broad range of substrate s... 50 5e-06
Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 50 6e-06
At5g51030 [Q] KOG1208 Dehydrogenases with different specificitie... 49 8e-06
7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 49 8e-06
>YOR246c [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 330
Score = 426 bits (1094), Expect = e-119
Identities = 202/324 (62%), Positives = 256/324 (78%), Gaps = 3/324 (0%)
Query: 10 LPYYDPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEI 69
LPYYDP V+ K+A+VTGGN+GIG+YTVLHLYLHGF VY+ GRNS +++ AI+EI EA+
Sbjct: 7 LPYYDPAVERKIAVVTGGNTGIGWYTVLHLYLHGFVVYICGRNSHKISKAIQEILAEAKK 66
Query: 70 RLRKGQDEKPHD---GLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAG 126
R + D G I++ G L Y+H+DLTDL VE+AA K EDH+DVL+NNAG
Sbjct: 67 RCHEDDDGSSPGAGPGPSIQRLGSLHYIHLDLTDLKCVERAALKILKLEDHIDVLVNNAG 126
Query: 127 VMAIPYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPG 186
+MA+P E+TKD FE+Q+QTNY+SHF+ TMRLLPL++ +GR+I++SS+GH+L F
Sbjct: 127 IMAVPLEMTKDGFEVQLQTNYISHFIFTMRLLPLLRHCRGRIISLSSIGHHLEFMYWKLS 186
Query: 187 AQFNYWPSMFFMWCRYALAKTASIQFTKMLAIKNPDILCMSLHPGLVMNTNLFSYCTRLP 246
++Y P+M F W RYA++KTA IQ TKMLAIK PD+LC+S+HPGLVMNTNLFSY TRLP
Sbjct: 187 KTWDYKPNMLFTWFRYAMSKTALIQCTKMLAIKYPDVLCLSVHPGLVMNTNLFSYWTRLP 246
Query: 247 FVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGYPSKPSRVA 306
VGIFFW+LFQ VG+FFGVSNEQG++++LKCAL +LS E DNG YFTTGG SK S V+
Sbjct: 247 IVGIFFWLLFQVVGFFFGVSNEQGSLASLKCALDPNLSVEKDNGKYFTTGGKESKSSYVS 306
Query: 307 NSLDNAASTWIWTVHELRDRGHEI 330
N++D AASTWIWTVH+LRDRG +I
Sbjct: 307 NNVDEAASTWIWTVHQLRDRGFDI 330
>SPCC736.13 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 339
Score = 148 bits (373), Expect = 1e-35
Identities = 103/289 (35%), Positives = 151/289 (51%), Gaps = 34/289 (11%)
Query: 15 PKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKG 74
P + KVALVTG + GIGY T L L G KVYL GRN + +K+I
Sbjct: 38 PDLTGKVALVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQI----------- 86
Query: 75 QDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYEL 134
DE H K+ +L +DL D SV +AA F +E+ L +L+NNAG+M P+EL
Sbjct: 87 HDEVRHS--------KIRFLRLDLLDFESVYQAAESFIAKEEKLHILVNNAGIMNPPFEL 138
Query: 135 TKDNFEIQMQTNYVSHFLLTMRLLPLIK-----ARKG--RVITVSSLGHNLIFFNCNPGA 187
TKD +E+Q+QTNY+SH+L T LLP ++ R G R++ V+S+ + ++
Sbjct: 139 TKDGYELQIQTNYLSHYLFTELLLPTLRRTAEECRPGDVRIVHVASIAYLQAPYSGIYFP 198
Query: 188 QFNYWPSMFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLFSYCTRL 245
N + + RY +K A I ++ LA ++ I +SLHPG V+ T L Y
Sbjct: 199 DLNLPHVLLGTFARYGQSKYAQILYSIALAKRLEKYGIYSVSLHPG-VIRTELTRYSPTF 257
Query: 246 PFVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFT 294
+L + V + + +GA+++L A S ++S E NGAYFT
Sbjct: 258 ALK-----LLEKSVFQYLLLDPIRGAMTSLYAATSPEISKEHLNGAYFT 301
>Hs20070272 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 318
Score = 122 bits (306), Expect = 7e-28
Identities = 96/279 (34%), Positives = 136/279 (48%), Gaps = 39/279 (13%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
++ KV +VTG N+GIG T L G +VYL R+ + KEI Q
Sbjct: 38 QLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEI-----------Q 86
Query: 76 DEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELT 135
+ +++RK +DL+D S+ A F +E HL VLINNAGVM PY T
Sbjct: 87 TTTGNQQVLVRK--------LDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKT 138
Query: 136 KDNFEIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSSLGHNL--IFFNCNPGAQFNYW 192
D FE+ + N++ HFLLT LL +K + R++ VSSL H+L I F+ G +F
Sbjct: 139 ADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKF--- 195
Query: 193 PSMFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLFSYCTRLPFVGI 250
+ Y +K A+I FT+ LA +K + S+HPG V S R
Sbjct: 196 ---YNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQ-----SELVRHSSFMR 247
Query: 251 FFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDN 289
+ W LF FF + +QGA ++L CAL+ L + N
Sbjct: 248 WMWWLFS----FFIKTPQQGAQTSLHCALTEGLEILSGN 282
>Hs21553325 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 330
Score = 120 bits (300), Expect = 4e-27
Identities = 89/285 (31%), Positives = 139/285 (48%), Gaps = 46/285 (16%)
Query: 11 PYYDPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIR 70
P + P+ D +VA+VTGG GIGY T HL G V + G N S+ + +IK+E
Sbjct: 36 PVFPPRPD-RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEET--- 91
Query: 71 LRKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAI 130
K+E+L+ DL + S+ + KF +++ L VLINNAGVM +
Sbjct: 92 ----------------LNDKVEFLYCDLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMV 135
Query: 131 PYELTKDNFEIQMQTNYVSHFLLTMRLLPLIK-----ARKGRVITVSSLGHNLIFFNCNP 185
P T+D FE NY+ HFLLT LL +K RV+TVSS H + N +
Sbjct: 136 PQRKTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDD 195
Query: 186 GAQFNYWPSMFFMWCRYALAKTASIQFT----KMLAIKNPDILCMSLHPGLVMNTNLFS- 240
+ + YA +K A + FT ++LA + + + PG V+NT+L+
Sbjct: 196 LQS----SACYSPHAAYAQSKLALVLFTYHLQRLLAAEGSHVTANVVDPG-VVNTDLYKH 250
Query: 241 --YCTRLPFVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDL 283
+ TRL + W+LF+ + ++GA +++ A++ +L
Sbjct: 251 VFWATRLA-KKLLGWLLFK--------TPDEGAWTSIYAAVTPEL 286
>Hs10190746 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 336
Score = 119 bits (299), Expect = 5e-27
Identities = 96/310 (30%), Positives = 157/310 (49%), Gaps = 29/310 (9%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
K L+TG NSG+G T L G +V +G R+ +R A ++++E LR+ + P
Sbjct: 44 KTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRE----LRQAAECGP 99
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNF 139
G + G+L +DL L SV + +E LDVLINNAG+ PY T+D F
Sbjct: 100 EPG--VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGF 157
Query: 140 EIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSSLGH---NLIFFNCNPGAQFNYWPSM 195
E+Q N++ HFLLT LL L+K + R++ VSS + ++ F + N +N
Sbjct: 158 EMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNK---- 213
Query: 196 FFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLFSYCTRLPFVGIFFW 253
+C Y+ +K A+I FT+ LA ++ ++ LHPG+V TNL R + +
Sbjct: 214 --SFC-YSRSKLANILFTRELARRLEGTNVTVNVLHPGIV-RTNL----GRHIHIPLLVK 265
Query: 254 ILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGYPSKPSRVANSLDNAA 313
LF V + F + +GA +++ A S ++ E +G YF G + + ++D +
Sbjct: 266 PLFNLVSWAFFKTPVEGAQTSIYLASSPEV--EGVSGRYF---GDCKEEELLPKAMDESV 320
Query: 314 STWIWTVHEL 323
+ +W + E+
Sbjct: 321 ARKLWDISEV 330
>7304178 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 115 bits (288), Expect = 9e-26
Identities = 92/280 (32%), Positives = 143/280 (50%), Gaps = 35/280 (12%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
+VA+VTG N GIG TVL L G VY+ R+ + +A +EI K
Sbjct: 15 RVAIVTGCNQGIGKETVLELARRGATVYMACRDMKKCENARREIIKATN----------- 63
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNF 139
+ + R+ +DL + S+ A F +++ L +LINNAG+M P LT+D F
Sbjct: 64 NQNIFARQ--------LDLCSMKSIRNFAAGFKREQNKLHILINNAGIMDCPKMLTEDGF 115
Query: 140 EIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSSLGHNLIFFNCNP-GAQFNYWPSMFF 197
E+Q+ N++ HFLLT+ LL ++K + RV+ +SS+ H + ++ +Y M
Sbjct: 116 EMQIGVNHMGHFLLTLLLLDVLKSSAPSRVVVLSSIAHRFGRIKRDDLNSEKSYDRKM-- 173
Query: 198 MWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLFSYCTRLPFVGIFFW-I 254
Y +K A++ FT+ LA + + +LHPG V+NT LF PF+G +F +
Sbjct: 174 ---AYCQSKLANVLFTRELAKRLSGTGVTVNALHPG-VVNTELF---RNTPFLGSWFGKL 226
Query: 255 LFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFT 294
L + + F + GA +TL AL D S E +G YF+
Sbjct: 227 LIAPIIWIFIKTARNGAQTTLYAAL--DPSLEKVSGRYFS 264
>7304177 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 300
Score = 115 bits (288), Expect = 9e-26
Identities = 103/313 (32%), Positives = 152/313 (47%), Gaps = 48/313 (15%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
KV +VTG N+GIG TVL + G VY+ R+ +R A ++I +E
Sbjct: 15 KVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETN----------- 63
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNF 139
+ + R+ +DL+ L S+ K A F ++D L VLINNAGVM P LTKD F
Sbjct: 64 NQNIFSRE--------LDLSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGF 115
Query: 140 EIQMQTNYVSHFLLTMRLLPLI-KARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSMFFM 198
E+Q+ N++ HFLLT LL ++ K R++ VSSL H F A N S +
Sbjct: 116 EMQLGVNHMGHFLLTHLLLDVLKKTAPSRIVNVSSLVHTQGFIKT---ADLNSEKS-YSR 171
Query: 199 WCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLFSYCTRL--PFVGI---- 250
Y+ +K A++ FT+ LA ++ + SLHPG V +T L L PF +
Sbjct: 172 IGAYSQSKLANVLFTRELAKRLEGTGVTTNSLHPGAV-DTELSRNWKFLKHPFAQLLLKP 230
Query: 251 FFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGYPSKPSRV-ANSL 309
W+LF+ + GA +TL AL D + + +G YF+ +P V A +
Sbjct: 231 LLWVLFK--------TPRNGAQTTLYAAL--DPALKDVSGLYFS----DCQPKEVSAAAQ 276
Query: 310 DNAASTWIWTVHE 322
D+ ++W E
Sbjct: 277 DDKTGKFLWAESE 289
>At2g37540 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 321
Score = 112 bits (280), Expect = 7e-25
Identities = 92/311 (29%), Positives = 145/311 (46%), Gaps = 45/311 (14%)
Query: 22 ALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHD 81
A++TGG SGIG L + G V + RN N + + I
Sbjct: 36 AIITGGTSGIGLEAARVLAMRGAHVIIAARNPKAANESKEMI------------------ 77
Query: 82 GLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEI 141
L + +++YL ID++ + SV +F L++LINNAGVM P++LT+D E
Sbjct: 78 -LQMNPNARVDYLQIDVSSIKSVRSFVDQFLALNVPLNILINNAGVMFCPFKLTEDGIES 136
Query: 142 QMQTNYVSHFLLTMRLLPLIKAR------KGRVITVSSLGHNLIFFNCNPGAQFN--YWP 193
Q TN++ HFLLT LL +K+ +GR++ +SS+ H + + G +F P
Sbjct: 137 QFATNHIGHFLLTNLLLDKMKSTARESGVQGRIVNLSSIAHT---YTYSEGIKFQGINDP 193
Query: 194 SMFFMWCRYALAKTASI----QFTKMLAIKNPDILCMSLHPGLVMNTNLFSYCTRLPFVG 249
+ + Y +K +++ ++ L + +I S+HPGLV TNLF Y
Sbjct: 194 AGYSERRAYGQSKLSNLLHSNALSRRLQEEGVNITINSVHPGLV-TTNLFRYSG------ 246
Query: 250 IFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGYPSKPSRVANSL 309
F +F+ + + F + QGA +T AL DL T G YF + PS+ A +
Sbjct: 247 -FSMKVFRAMTFLFWKNIPQGAATTCYVALHPDLEGVT--GKYFGDCNIVA-PSKFATNN 302
Query: 310 DNAASTWIWTV 320
A W ++V
Sbjct: 303 SLADKLWDFSV 313
>7304180 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 327
Score = 111 bits (277), Expect = 2e-24
Identities = 92/312 (29%), Positives = 150/312 (47%), Gaps = 46/312 (14%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
KVA+VTGGN+G+G TV+ L G VY+ RN +V A +EI KE
Sbjct: 46 KVAIVTGGNTGLGKETVMELARRGATVYMACRNKEKVERARREIVKETG----------- 94
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNF 139
+ + R+ DL+ L+S+ K A F ++ L +LINNAGV P+ LTK+ F
Sbjct: 95 NSNVFSREC--------DLSSLDSIRKFAENFKKEQRVLHILINNAGVFWEPHRLTKEGF 146
Query: 140 EIQMQTNYVSHFLLTMRLLPLI-KARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSMFFM 198
E+ + N++ HFLLT LL ++ ++ RV+ V+S H + +++
Sbjct: 147 EMHLGVNHIGHFLLTNLLLGVLERSAPSRVVVVASRAHERGQIKVDDINSSDFYDE---- 202
Query: 199 WCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLV---MNTNLFSYCTRL--PFVGIF 251
Y +K A+I FT+ LA ++ + +L+PG+ + N+ + T+ +
Sbjct: 203 GVAYCQSKLANILFTRELAKRLEGTGVTVNALNPGIADTEIARNMIFFQTKFAQTILRPL 262
Query: 252 FWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGY-PSKPSRVANSLD 310
W + + + + GA +TL AL DL E +G YF+ P P+ +LD
Sbjct: 263 LWAVMK--------TPKNGAQTTLYAALDPDL--ERVSGQYFSDCALAPVAPA----ALD 308
Query: 311 NAASTWIWTVHE 322
+ + W+W E
Sbjct: 309 DQMAQWLWAQSE 320
>7304181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 331
Score = 109 bits (272), Expect = 6e-24
Identities = 97/313 (30%), Positives = 144/313 (45%), Gaps = 48/313 (15%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
KV +VTG N+GIG TV + G VY+ RN + A +EI E +
Sbjct: 46 KVFIVTGANTGIGKETVREIAKRGGTVYMACRNLKKCEEAREEIVLETK----------- 94
Query: 80 HDGLMIRKTGKLEYLH-IDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDN 138
K Y DL S+ F +++HL VLINNAGVM P LT D
Sbjct: 95 ---------NKYVYCRQCDLASQESIRHFVAAFKREQEHLHVLINNAGVMRCPRSLTSDG 145
Query: 139 FEIQMQTNYVSHFLLTMRLLPLI-KARKGRVITVSSLGHNLIFFN---CNPGAQFNYWPS 194
E+Q+ N++ HFLLT LL L+ K+ R++ VSSL H N N ++ +
Sbjct: 146 IELQLGVNHMGHFLLTNLLLDLLKKSSPSRIVNVSSLAHTRGEINTGDLNSDKSYDEGKA 205
Query: 195 MFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLFSYCTRLP--FVGI 250
Y+ +K A++ FT+ LA ++ ++ +LHPG V++T + + F G+
Sbjct: 206 -------YSQSKLANVLFTRELAKRLEGTNVTANALHPG-VVDTEIIRHMGFFNNFFAGL 257
Query: 251 FFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGYPSKPSRVA-NSL 309
F LF + F + GA ++L AL +L T G YF+ K +A +
Sbjct: 258 FVKPLF----WPFVKTPRNGAQTSLYVALDPELEKVT--GQYFS----DCKLKEMAPAAT 307
Query: 310 DNAASTWIWTVHE 322
D + W+W V E
Sbjct: 308 DTQTAKWLWAVSE 320
>Hs18582884 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 108 bits (270), Expect = 1e-23
Identities = 89/284 (31%), Positives = 139/284 (48%), Gaps = 41/284 (14%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
++ KV ++TG N+GIG T L G +VY+ R+ + A EI+ + +
Sbjct: 36 QLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTK------- 88
Query: 76 DEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELT 135
+ +++RK +DL+D S+ A F +E L +LINNAGVM PY T
Sbjct: 89 ----NSQVLVRK--------LDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKT 136
Query: 136 KDNFEIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSSLGHNL--IFFNCNPGAQFNYW 192
D FE + N++ HFLLT LL +K + RV+ VSS+ H++ I F+ Q
Sbjct: 137 ADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFH---DLQSEKR 193
Query: 193 PSMFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLFSYCTRLPFVGI 250
S F +C +K A++ FT+ LA ++ + ++HPG+V S R +
Sbjct: 194 YSRGFAYCH---SKLANVLFTRELAKRLQGTGVTTYAVHPGVVR-----SELVRHSSLLC 245
Query: 251 FFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFT 294
W LF F + +GA ++L CAL+ L E +G YF+
Sbjct: 246 LLWRLFS----PFVKTAREGAQTSLHCALAEGL--EPLSGKYFS 283
>At4g11410 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 107 bits (267), Expect = 2e-23
Identities = 94/307 (30%), Positives = 140/307 (44%), Gaps = 45/307 (14%)
Query: 22 ALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHD 81
A+VTG +SGIG T L L G V + RN+ N +I KE
Sbjct: 32 AIVTGASSGIGEETTRVLALRGVHVVMAVRNTDSGNQVRDKILKEIP------------- 78
Query: 82 GLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEI 141
K++ + +DL+ + SV A+++ + L++LINNAG+MA P+ L+ DN E+
Sbjct: 79 ------QAKIDVMKLDLSSMASVRSFASEYQSLDLPLNLLINNAGIMACPFLLSSDNIEL 132
Query: 142 QMQTNYVSHFLLTMRLLPLIKA------RKGRVITVSSLGHNLIFFNCNPGAQFNYW--P 193
Q TN++ HFLLT LL +K R+GR++ VSS GH F G QF+
Sbjct: 133 QFATNHLGHFLLTNLLLERMKKTASESNREGRIVIVSSEGHR---FAYREGVQFDKINDE 189
Query: 194 SMFFMWCRYALAKTASI----QFTKMLAIKNPDILCMSLHPGLVMNTNLFSYCTRLPFVG 249
+ + Y +K +I + ++ + +I SLHPG +M TNL Y + + +G
Sbjct: 190 ARYNTLQAYGQSKLGNILHATELARLFKEQGVNITANSLHPGSIM-TNLLRYHSFINTIG 248
Query: 250 IFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGYPSKPSRVANSL 309
VG + S QGA +T AL A+ +G Y S P+
Sbjct: 249 -------NAVGKYVLKSIPQGAATTCYAALHP--QAKGVSGEYLMDNNI-SDPNSQGKDK 298
Query: 310 DNAASTW 316
D A W
Sbjct: 299 DLAKKLW 305
>7297326 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 409
Score = 106 bits (264), Expect = 5e-23
Identities = 94/314 (29%), Positives = 146/314 (45%), Gaps = 49/314 (15%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
+ AL+TG N GIGY T L HG ++ RN S AI+ I +E
Sbjct: 122 RTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAA--------- 172
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNF 139
+ + +DL+ L SV++ + H+D LI NAGV A+PY T D
Sbjct: 173 --------RSRCRFAALDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGL 224
Query: 140 EIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGH--------NLIFFNCNPGAQFNY 191
E Q +++SHF LT++L L K R+I +SS H NL + +P + Y
Sbjct: 225 ETTFQVSHLSHFYLTLQLETLFD-YKTRIIVLSSESHRFANLPVENLAVHHLSPPPE-KY 282
Query: 192 WPSMFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLF-SYCTRLPFV 248
W M Y AK ++ F + LA K I SLHPG +++++L +Y
Sbjct: 283 WSMM-----AYNNAKLCNVLFAQELAQRWKQRGISVFSLHPGNMVSSDLSRNYW------ 331
Query: 249 GIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGYPSKPSRVANS 308
F+ +LF V F S +Q A +++ CA +++L+ +G YF + +PS+++ S
Sbjct: 332 --FYRLLFAIVRP-FTKSLQQAAATSIYCATANELTGL--SGLYFNNCFF-CEPSKLSKS 385
Query: 309 LDNAASTWIWTVHE 322
A +W + E
Sbjct: 386 A--ALQQQLWKLSE 397
>7290709 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 406
Score = 106 bits (264), Expect = 5e-23
Identities = 94/286 (32%), Positives = 138/286 (47%), Gaps = 40/286 (13%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
++D KV +VTG N+GIG TVL L G +VY+ R+ R A +I
Sbjct: 71 RIDGKVVIVTGCNTGIGKETVLELAKRGARVYMACRDPGRCEAARLDIM----------- 119
Query: 76 DEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELT 135
++ + + +T +DL L SV +F +E LD+LINNAGVMA P LT
Sbjct: 120 -DRSRNQQLFNRT-------LDLGSLQSVRNFVERFKAEESRLDILINNAGVMACPRTLT 171
Query: 136 KDNFEIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSSLGHNLIFFNCNPG---AQFNY 191
D FE Q N++ HFLLT LL +K + R++ VSS H +F N ++ NY
Sbjct: 172 ADGFEQQFGVNHLGHFLLTNLLLDRLKHSSPSRIVVVSSAAH--LFGRINREDLMSEKNY 229
Query: 192 WPSMFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLFSYCTRLPFVG 249
S FF Y+ +K A+I FT L+ +K+ + HPG V+ T + + F G
Sbjct: 230 --SKFF--GAYSQSKLANILFTLKLSTILKDTGVTVNCCHPG-VVRTEINRH-----FSG 279
Query: 250 I-FFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFT 294
+ Q +F + + GA + L+ AL L T G Y++
Sbjct: 280 PGWMKTALQKGSLYFFKTPKAGAQTQLRLALDPQLEGST--GGYYS 323
>Hs7706523 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 414
Score = 102 bits (254), Expect = 8e-22
Identities = 90/314 (28%), Positives = 138/314 (43%), Gaps = 37/314 (11%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
KV +VTG NSGIG+ T LHG V L RN +R + A+ I +E
Sbjct: 125 KVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWH----------- 173
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNF 139
K+E + +DL L SV+ A F + L VL+ NA A+P+ LTKD
Sbjct: 174 --------KAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGL 225
Query: 140 EIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSLGHNLIFFNCNPG----AQFNYWPS 194
E Q N++ HF L L L ++ RVI VSS H N + G ++ + +
Sbjct: 226 ETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKN 285
Query: 195 MFFMWCRYALAKTASIQFTKML--AIKNPDILCMSLHPGLVMNTNLFSYCTRLPFVGIFF 252
++ Y +K +I F+ L + + ++HPG +M +N+ +
Sbjct: 286 DYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR--------SWWV 337
Query: 253 WILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGYPSKPSRVANSLDNA 312
+ L + F S +QGA +T+ CA +L E G YF PS A S + A
Sbjct: 338 YTLLFTLARPFTKSMQQGAATTVYCAAVPEL--EGLGGMYF-NNCCRCMPSPEAQSEETA 394
Query: 313 ASTWIWTVHELRDR 326
+ W + +++R
Sbjct: 395 RTLWALSERLIQER 408
>7304176 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 280
Score = 102 bits (254), Expect = 8e-22
Identities = 92/322 (28%), Positives = 147/322 (45%), Gaps = 75/322 (23%)
Query: 14 DPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRK 73
D KV +VTG N+GIG T L + G VYL R+ +R A K+I KE
Sbjct: 9 DTDETGKVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARKDIIKETN----- 63
Query: 74 GQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYE 133
+ + R+ +DL+ L+S+ K F ++ L VLINNAGVM P
Sbjct: 64 ------NQNIFSRE--------LDLSSLDSIRKFVDGFKKEQPKLHVLINNAGVMRCPKT 109
Query: 134 LTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQFNYWP 193
LTKD +E+Q+ N++ HFLLT LL ++KA + ++ +Y
Sbjct: 110 LTKDGYELQLGVNHIGHFLLTNLLLDVLKA-------------------TDLNSEKSYDE 150
Query: 194 SMFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLV----------MNTNLFSY 241
+ Y+ +K A++ FT+ LA ++ + +LHPG+V TNL +
Sbjct: 151 GL-----AYSQSKLANVLFTRELAKRLEGSGVTVNALHPGVVDTELARNWAFFQTNLVKF 205
Query: 242 CTRLPFVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGYPSK 301
F+ W L + + + GA +++ AL +L + +G YF+ K
Sbjct: 206 -----FLKPMIWPLLK--------TPKSGAQTSIYAALDPEL--KNISGLYFS----DCK 246
Query: 302 PSRVAN-SLDNAASTWIWTVHE 322
P VA+ +LD+ + ++W E
Sbjct: 247 PKPVASGALDDKVAKFLWAESE 268
>At5g02540 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 350
Score = 96.7 bits (239), Expect = 4e-20
Identities = 89/333 (26%), Positives = 143/333 (42%), Gaps = 64/333 (19%)
Query: 19 NKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEK 78
N A++TGG GIG T L G V +G RN +A EI ++
Sbjct: 33 NLTAIITGGTGGIGMETARVLSKRGAHVVIGARNMGAAENAKTEILRQ------------ 80
Query: 79 PHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLI---------------- 122
++ L +DL+ + S++ +F L++L+
Sbjct: 81 -------NANARVTLLQLDLSSIKSIKAFVREFHALHLPLNLLMYTFSLSLIQFKAFAPP 133
Query: 123 ---NNAGVMAIPYELTKDNFEIQMQTNYVSHFLLTMRLLPLIK------ARKGRVITVSS 173
NNAGVM PY+L++D E+Q TN++ HFLLT LL +K +GR++ VSS
Sbjct: 134 FLANNAGVMFCPYQLSEDGIELQFATNHIGHFLLTNLLLDTMKNTAKTSGVEGRILNVSS 193
Query: 174 LGHNLIFFNCNPGAQFNYWPSM--FFMWCRYALAKTASI----QFTKMLAIKNPDILCMS 227
+ H + G QF+ + + Y +K A+I + ++ L + +I S
Sbjct: 194 VAH---IYTYQEGIQFDSINDICSYSDKRAYGQSKLANILHANELSRQLQEEGVNITANS 250
Query: 228 LHPGLVMNTNLFSYCTRLPFVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAET 287
+HPGL++ TNLF + L +F ++ + QGA +T AL + T
Sbjct: 251 VHPGLIL-TNLFQHTALL-------MRFLKFFSFYLWKNIPQGAATTCYVALHPSVKGVT 302
Query: 288 DNGAYFTTGGYPSKPSRVANSLDNAASTWIWTV 320
G YF + PS++A A W ++V
Sbjct: 303 --GKYFADCNEVT-PSKLARDETLAQKLWDFSV 332
>7300379 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 266
Score = 95.1 bits (235), Expect = 1e-19
Identities = 71/233 (30%), Positives = 111/233 (47%), Gaps = 13/233 (5%)
Query: 14 DPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRL-- 71
D ++ ++ +VTGGNSGIG+ L G ++ L RN A IK+E R
Sbjct: 38 DNQIKEQIVVVTGGNSGIGFEIAQALAGRGGRIILACRNLEAGKRAAAIIKRELGCRTPL 97
Query: 72 -RKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAI 130
+D+ P D + E ++DL L SV A + + + +DVL+NNAGV+
Sbjct: 98 NSLDEDDNPEDRYFV------EARYLDLCSLRSVHHFAGQLMAEFERIDVLVNNAGVVFA 151
Query: 131 PYEL-TKDNFEIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSLGHNLIFFNCNPGAQ 188
++ T+D FE Q NY++ FLLT LLP L ++ +GR++ VS+ H + +
Sbjct: 152 NTQMPTEDGFERHSQVNYLAPFLLTHLLLPHLQRSEQGRILFVSAHAHQGAKIDFDDPLN 211
Query: 189 FNYWPSMFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLVMNTNLF 239
W F +A +K + T+ +A +K + PGLV T F
Sbjct: 212 VGTWSVKFHAREAFAHSKLCVLLATRWMARELKGTSVTVNCCTPGLVRGTRHF 264
>7302393 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 355
Score = 94.4 bits (233), Expect = 2e-19
Identities = 84/292 (28%), Positives = 136/292 (45%), Gaps = 45/292 (15%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
K +++A++TGGN GIG V L V +G R+ A+ I ++ KG
Sbjct: 64 KQPDRIAVITGGNRGIGLRIVEKLLACDMTVVMGVRDPKIAETAVASI---VDLNATKG- 119
Query: 76 DEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELT 135
KL +D+ DL SV+ A + +D+L+NNAG+M P++LT
Sbjct: 120 --------------KLICEQLDVGDLKSVKAFAQLIKERYSKVDLLLNNAGIMFAPFKLT 165
Query: 136 KDNFEIQMQTNYVSHFLLTMRLLPLIKA-----RKGRVITVSSLGHNLIFFNCNP-GAQF 189
D +E N++ HFLLT LLP ++A R R++ VSS + + N
Sbjct: 166 ADGYESHFAINFLGHFLLTHLLLPQLRAAGKEGRNSRIVNVSSCVNLIGRINYKDINGTK 225
Query: 190 NYWPSMFFMWCRYALAKTASIQFTK----MLAIKNPDILCMSLHPGLVMNTNLFSYCTRL 245
+Y+P Y+ +K A I FT+ +L + + +HPG+V +T+LF + +
Sbjct: 226 HYYPG-----TAYSQSKLAQILFTRHLQTLLDAEKSHVQVNVVHPGIV-DTDLFEH-SAT 278
Query: 246 PFVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGG 297
V IF + F+ + E+G+ + + A+ D S E G Y + GG
Sbjct: 279 TSVPIFKKLFFK--------TPERGSRTVVFAAI--DPSIEGQGGTYLSNGG 320
>Hs13699258 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 363
Score = 92.8 bits (229), Expect = 6e-19
Identities = 69/226 (30%), Positives = 104/226 (45%), Gaps = 26/226 (11%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
KV +VTG NSGIG+ T LHG V L RN +R + A+ I +E
Sbjct: 125 KVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWH----------- 173
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNF 139
K+E + +DL L SV+ A F + L VL+ NA A+P+ LTKD
Sbjct: 174 --------KAKVETMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGL 225
Query: 140 EIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSLGHNLIFFNCNPG----AQFNYWPS 194
E Q N++ HF L L L ++ RVI VSS H N + G ++ + +
Sbjct: 226 ETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKN 285
Query: 195 MFFMWCRYALAKTASIQFTKML--AIKNPDILCMSLHPGLVMNTNL 238
++ Y +K +I F+ L + + ++HPG +M +N+
Sbjct: 286 DYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNI 331
>Hs19923931 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 260
Score = 88.6 bits (218), Expect = 1e-17
Identities = 57/169 (33%), Positives = 87/169 (50%), Gaps = 11/169 (6%)
Query: 95 HIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEIQMQTNYVSHFLLT 154
H+DL L S+ + A K +E+ +D+LINNAGVM P+ T+D FE+Q N++ HFLLT
Sbjct: 24 HLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLT 83
Query: 155 MRLLPLIKA-RKGRVITVSSLGHNLIFFNCNPGAQFNYWPSMFFMWCRYALAKTASIQFT 213
LL +KA R+I +SSL H + + N+ + Y +K A + FT
Sbjct: 84 NLLLDKLKASAPSRIINLSSLAHVAGHIDFD---DLNWQTRKYNTKAAYCQSKLAIVLFT 140
Query: 214 KMLA--IKNPDILCMSLHPG-----LVMNTNLFSYCTRLPFVGIFFWIL 255
K L+ ++ + +LHPG L +T + +G FW+L
Sbjct: 141 KELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLL 189
>CE08181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 333
Score = 87.0 bits (214), Expect = 3e-17
Identities = 76/225 (33%), Positives = 108/225 (47%), Gaps = 29/225 (12%)
Query: 21 VALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPH 80
VA+VTG N GIG+ TV L L VY+ R+ + N A + + +R+G D
Sbjct: 48 VAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKRML-------VRQGCDAT-- 98
Query: 81 DGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVM-AIPYELTKDNF 139
+L ++ DLTD SV +AA + D +D+LINNAG+M +E TKD
Sbjct: 99 ---------RLHFIECDLTDFESVRRAAKETLESTDTIDILINNAGIMFQSKHEQTKDGH 149
Query: 140 EIQMQTNYVSHFLLTMRLLPLI-KARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSMFFM 198
E Q+N++ FLLT LP + K+ R+I VSS H L N + F M
Sbjct: 150 EKTWQSNHLGPFLLTELFLPAVKKSSYARIINVSSRIH-LKSEKINLATVDD--KKSFGM 206
Query: 199 WCRYALAKTASIQFTKMLAIK-----NPDILCMSLHPGLVMNTNL 238
Y +K A++ + L + + SLHPG V+NT L
Sbjct: 207 MKSYRQSKLANVMHARALTKELRKDGAEHVTVNSLHPG-VVNTEL 250
>At5g50130 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 85.5 bits (210), Expect = 1e-16
Identities = 66/222 (29%), Positives = 112/222 (49%), Gaps = 30/222 (13%)
Query: 22 ALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHD 81
A++TGG SGIG T L G +V + R+ + E+ KE IR E P
Sbjct: 39 AIITGGTSGIGAETARVLAKRGVRVVMAVRDMKKA-----EMVKERIIR------ENPEA 87
Query: 82 GLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEI 141
+++ IDL+ L+SV + ++F Q+ L++LINNAGV + E +++ E+
Sbjct: 88 DIIL--------FEIDLSSLSSVARFCSQFLSQDLPLNILINNAGVFSPNLEFSEEKIEL 139
Query: 142 QMQTNYVSHFLLTMRLLPLI------KARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSM 195
TN++ H+LLT L+ + +GR+I +SS+ HN + +C + + P
Sbjct: 140 TFATNFLGHYLLTEMLIEKMIDTAEKSGIEGRIINLSSVIHNWVKPDCFSFPKLLH-PIR 198
Query: 196 FFMWCRYALAKTASI----QFTKMLAIKNPDILCMSLHPGLV 233
+ YA +K A+I +K L +N ++ ++HPG+V
Sbjct: 199 YNGTRAYAQSKLATILHAKALSKQLKDRNANVTINAVHPGIV 240
>At5g53090 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 364
Score = 84.3 bits (207), Expect = 2e-16
Identities = 83/322 (25%), Positives = 149/322 (45%), Gaps = 42/322 (13%)
Query: 15 PKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKG 74
P +++ +VTG SGIG T L G +V + RN+ + I++ +KE +
Sbjct: 41 PSLNHLTCIVTGSTSGIGRETARQLAEAGARVVMAVRNTKAAHELIQQWQKEWSGK---- 96
Query: 75 QDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYE- 133
G+ + LE + +DL L+SV + + L VLINNAG+ ++ E
Sbjct: 97 -------GIPL----NLEAMELDLLSLDSVVGFCNLWNARLSPLHVLINNAGIFSMGEEQ 145
Query: 134 -LTKDNFEIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSLGHNLIFFNCNPGAQFNY 191
+KD +E MQ N+++ LL++ LLP LI+ R+I V+S+ H + F + +
Sbjct: 146 KFSKDGYEQHMQVNHLAPALLSLLLLPSLIRGSPSRIINVNSVMHYVGFVDPD-DMNVVS 204
Query: 192 WPSMFFMWCRYALAKTASIQFTKMLAIKNP-----DILCMSLHPGLVMNTNLFSYCTRLP 246
F Y+ +K A + F+ +L + P ++C+S PG+V+ TN+ R
Sbjct: 205 GKRKFTSLVGYSGSKLAQVMFSNVLLKRLPLETRISVVCLS--PGIVL-TNVARDLPR-- 259
Query: 247 FVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDN--------GAYFTTGGY 298
+ + + + YF S ++G+ STL A + + + + +
Sbjct: 260 ----YVQVQYALIPYFI-FSPQEGSRSTLFSATDAQIPEHCEKLKTEDKPVCTFISQNCK 314
Query: 299 PSKPSRVANSLDNAASTWIWTV 320
+KPS A++++ A W T+
Sbjct: 315 HTKPSEEAHNVETAERVWEKTI 336
>At5g53100 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 364
Score = 82.0 bits (201), Expect = 1e-15
Identities = 70/245 (28%), Positives = 122/245 (49%), Gaps = 25/245 (10%)
Query: 9 KLPYYDPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAE 68
++P++ P +++ +VTG SGIG T L G V + RN + I++ + +
Sbjct: 34 QIPFHLPPLNHLTCIVTGSTSGIGSETARQLAEAGAHVVMAVRNIKAAHELIQQWQTKW- 92
Query: 69 IRLRKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVM 128
+GL + ++ + +DL L+SV + + + + L VLINNAG+
Sbjct: 93 --------SASGEGLPL----NIQAMELDLLSLDSVVRFSNAWNARLAPLHVLINNAGMF 140
Query: 129 AI--PYELTKDNFEIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSLGHNLIFFNCNP 185
A+ + ++D +E MQ N+++ LL++ LLP LI+A + R+I V+S+ H + F + N
Sbjct: 141 AMGGAQKFSEDGYEQHMQVNHLAPALLSLLLLPSLIRASRSRIINVNSVMHYVGFVDPN- 199
Query: 186 GAQFNYWPSMFFMWCRYALAKTASIQFTKMLAIKNP-----DILCMSLHPGLVMNTNLFS 240
F F Y+ +K A + F +L K P ++C+S PG V+ TN+
Sbjct: 200 DMNFVSGKRKFSSLSAYSSSKLAQVMFNNVLLKKLPLETGISVVCLS--PG-VVQTNITR 256
Query: 241 YCTRL 245
RL
Sbjct: 257 DLPRL 261
>CE07803 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 323
Score = 81.6 bits (200), Expect = 1e-15
Identities = 68/234 (29%), Positives = 104/234 (44%), Gaps = 41/234 (17%)
Query: 23 LVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHDG 82
LVTG G+G +T L+ G V L R+ R HA++ + + + E+ H
Sbjct: 7 LVTGSTCGLGLHTAKILFKKGANVILTCRDEIRGRHAVESLLSGVSQEQSQKEAERIH-- 64
Query: 83 LMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEIQ 142
+D+T+ NS+ + + +L V+INNAG+M +P+EL+ D E+
Sbjct: 65 ----------LFTLDVTNYNSICNFTDEISRMFKYLHVIINNAGIMGMPFELSVDGIEMH 114
Query: 143 MQTNYVSHFLLTMRLLPLIKAR-----KGRVITVSSLGHNLIFFNCNPGAQ--------- 188
TN H+++ RLLPL+ K RVI VSS ++ N Q
Sbjct: 115 FATNVFGHYVVVERLLPLLLKTDRPDFKSRVIVVSS----GLYRNAEAIPQVSKLLGQKT 170
Query: 189 FNYWPSMFFMWCRYALAKTASIQFT----KMLAIKNPDILCMSLHPGLVMNTNL 238
++Y P YA +K A+ +T KML N + C + PG V T L
Sbjct: 171 YDYSPKQ-----AYAFSKLANCLYTGALSKMLEPHNVGVYC--VRPGFVNGTEL 217
>At4g27760 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 374
Score = 81.6 bits (200), Expect = 1e-15
Identities = 86/317 (27%), Positives = 148/317 (46%), Gaps = 42/317 (13%)
Query: 15 PKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKG 74
P V++ +VTG SGIG T L G V + RN+ K A+ + +
Sbjct: 53 PSVNDLTCVVTGSTSGIGRETARQLAEAGAHVVMAVRNT-----------KAAQELILQW 101
Query: 75 QDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAI--PY 132
Q+E GL + +E + IDL L+SV + A F + L VLINNAG+ A+
Sbjct: 102 QNEWSGKGLPLN----IEAMEIDLLSLDSVARFAEAFNARLGPLHVLINNAGMFAMGEAQ 157
Query: 133 ELTKDNFEIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSLGHNLIFFNCNP----GA 187
+ +++ +E MQ N+++ LL++ LLP LI+ R+I V+S+ H++ F + +
Sbjct: 158 KFSEEGYEQHMQVNHLAPALLSVLLLPSLIRGSPSRIINVNSVMHSVGFVDPDDMNVVSG 217
Query: 188 QFNYWPSMFFMWCRYALAKTASIQFTKMLAIKNPDILCMSLHPGLVMNTNLFSYCTRLPF 247
+ Y S + L +SI F K+ ++C+S PG+V+ TN+ +R+
Sbjct: 218 RRKY--SSLIGYSSSKLIMFSSILFKKLPLETGVSVVCLS--PGVVL-TNVARDLSRI-- 270
Query: 248 VGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDL-----SAETDNG---AYFTTGGYP 299
L+ + YF S ++G S+L A + + + D+ + + P
Sbjct: 271 ----LQALYAVIPYFI-FSPQEGCRSSLFSATDPQIPEYWETLKNDDWPVCPFISQDCRP 325
Query: 300 SKPSRVANSLDNAASTW 316
+ PS A++ + A W
Sbjct: 326 ANPSEEAHNTETAQRVW 342
>At4g23430 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 294
Score = 81.6 bits (200), Expect = 1e-15
Identities = 60/192 (31%), Positives = 92/192 (47%), Gaps = 45/192 (23%)
Query: 22 ALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHD 81
A+VTG +SGIG T L L G V + RN+ ++I K+
Sbjct: 32 AIVTGASSGIGVETARVLSLRGVHVVMAVRNTDSGAKVKEDIVKQVP------------- 78
Query: 82 GLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLI-----------------NN 124
KL+ + +DL+ + SV K A+++ L++LI NN
Sbjct: 79 ------GAKLDVMELDLSSMQSVRKFASEYKSTGLPLNLLIGFDLLMVNVLNCLNLVSNN 132
Query: 125 AGVMAIPYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKA------RKGRVITVSSLGHNL 178
AG+MA P+ L+KDN E+Q TN++ HFLLT LL +K+ R+GR++ +SS H
Sbjct: 133 AGIMACPFMLSKDNIELQFATNHLGHFLLTKLLLDTMKSTSRESKREGRIVNLSSEAHR- 191
Query: 179 IFFNCNPGAQFN 190
F+ G +F+
Sbjct: 192 --FSYPEGVRFD 201
>7300387 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 80.5 bits (197), Expect = 3e-15
Identities = 63/226 (27%), Positives = 104/226 (45%), Gaps = 27/226 (11%)
Query: 12 YYDPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRL 71
+ + K++ K ++TG NSGIG T L G ++ + RN N EI KE
Sbjct: 26 FTETKMEGKTVIITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKET---- 81
Query: 72 RKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGV-MAI 130
K K+ +DL SV + A E +DVLI+NAG+ +A
Sbjct: 82 ---------------KNNKILVKKLDLGSQKSVREFAADIVKTEPKIDVLIHNAGMALAF 126
Query: 131 PYELTKDNFEIQMQTNYVSHFLLTMRLLPLI-KARKGRVITVSSLGHNLIFFNCNPGAQF 189
+ ++D E+ M TN+ FLLT L+ ++ K+ R++ V+S + L N
Sbjct: 127 RGQTSEDGVELTMATNHYGPFLLTHLLIDVLKKSAPARIVIVASELYRLSSVNLAKLNPI 186
Query: 190 NYWPSMFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPGLV 233
+P+ + Y ++K A+I F + LA ++ + LHPG++
Sbjct: 187 GTFPAAYL----YYVSKFANIYFARELAKRLEGTKVTVNFLHPGMI 228
>At5g15940 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 346
Score = 79.0 bits (193), Expect = 9e-15
Identities = 85/318 (26%), Positives = 129/318 (39%), Gaps = 53/318 (16%)
Query: 21 VALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPH 80
+ ++TG SG+G T L GF V L GR+S ++ +KEIK K
Sbjct: 43 ICVITGATSGLGKATAFALAEKGFYVVLVGRSSQLLSETLKEIKN------------KNK 90
Query: 81 DGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFE 140
D + + T NS+E+ + + + VL+NNAG++A T D ++
Sbjct: 91 DAQLKSFEADMSSFESIFTFKNSLEQWLSDSALHPS-IQVLVNNAGILATSSRPTIDGYD 149
Query: 141 IQMQTNYVSHFLLTMRLLPLIKARK--GRVITVSSLGHNLIFF----------------N 182
+ TNYV F LT LLPL+K RV+ V+S H+ F N
Sbjct: 150 RMIATNYVGPFFLTKLLLPLLKNSNVPSRVVNVTSFTHHSAFIQKLDKDSVTGVCFSTSN 209
Query: 183 CNPGAQFNYWPSMFFMWCRYALAKTASIQFTKMLAIKNPDILCMSLHPGLVMNTNLF--- 239
P A+ + + + Y L + L + + ++ PG V TN+
Sbjct: 210 QYPCARIYEYSKLCLLLFSYELHRQL------RLIDDSSHVSVIAADPGFV-KTNIMREL 262
Query: 240 -SYCTRLPFVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYFTTGGY 298
Y T + F+G F+ +G S E GA S + ALS + ET YF G
Sbjct: 263 PCYITSMVFLG------FKILGLL--QSPEDGAESIIDAALS---TPETSGAYYFGGKGR 311
Query: 299 PSKPSRVANSLDNAASTW 316
+ S+V+ A W
Sbjct: 312 TIESSQVSRDPKLAKQLW 329
>CE20634 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 398
Score = 77.8 bits (190), Expect = 2e-14
Identities = 71/277 (25%), Positives = 119/277 (42%), Gaps = 39/277 (14%)
Query: 17 VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQD 76
+ K +TG SG+G T L G + + RN +A E K++ +
Sbjct: 104 LSGKTYAITGTTSGVGTETARAFILKGAHIVMINRN-----YAASETLKQSLLC------ 152
Query: 77 EKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTK 136
E P +++ + DL+ L SV+K A ++ ++ L LI NAGV+ + T
Sbjct: 153 ETPD--------ARIDIVQCDLSSLASVKKTAEEYLTKKWPLHGLILNAGVLGRKEKTTA 204
Query: 137 DNFEIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSSLGHNLIFFNCNPGAQF-----N 190
D FE N+++HFLL LLP+++ + R++ +SS F + NP ++
Sbjct: 205 DRFEAHFGINHLAHFLLIKELLPVLRSSAPSRIVILSSTLSK--FTSINPDSKIEEKLGT 262
Query: 191 YWPSMFFMWCRYALAKTASIQFTKMLAIKNPD----ILCMSLHPGLVMNTNLFSYCTRLP 246
P W AK+ + + I S+HPG + TNL
Sbjct: 263 LCPKNATEWYYRLYAKSKMCNMLIAFKLHRDEFENGISVYSVHPGSAVRTNLHR------ 316
Query: 247 FVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDL 283
+ FW +F F+ F + QGA ++L CA+ ++
Sbjct: 317 --DVPFWSIFNFLSIPFTKNASQGAATSLYCAVHPEV 351
>Hs21389583 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 327
Score = 73.2 bits (178), Expect = 5e-13
Identities = 76/266 (28%), Positives = 119/266 (44%), Gaps = 42/266 (15%)
Query: 35 TVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHDGLMIRKTGKLEYL 94
T L L G +V L R+ R A ++++E+ G +E + ++
Sbjct: 2 TALELARRGARVVLACRSQERGEAAAFDLRQES------GNNE-------------VIFM 42
Query: 95 HIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEIQMQTNYVSHFLLT 154
+DL L SV AT F E LD+LI+NAG+ + T++ F + ++ N++ FLLT
Sbjct: 43 ALDLASLASVRAFATAFLSSEPRLDILIHNAGISSC--GRTREAFNLLLRVNHIGPFLLT 100
Query: 155 MRLLPLIKA-RKGRVITVSSLGHNLIFFNCNPGAQFNYWPSMFFMWCR----YALAKTAS 209
LLP +KA RV+ V+S H C F W + YA K A+
Sbjct: 101 HLLLPCLKACAPSRVVVVASAAH------CRGRLDFKRLDRPVVGWRQELRAYADTKLAN 154
Query: 210 IQFTKMLA--IKNPDILCMSLHPGLVMNTNLFSYCTRLPFVGIFFWILFQFVGYFFGVSN 267
+ F + LA ++ + C + HPG V N+ LF L V + L + + + +
Sbjct: 155 VLFARELANQLEATGVTCYAAHPGPV-NSELF-----LRHVPGWLRPLLRPLAWLVLRAP 208
Query: 268 EQGAISTLKCALSSDLSAETDNGAYF 293
GA + L CAL + E +G YF
Sbjct: 209 RGGAQTPLYCALQEGI--EPLSGRYF 232
>CE16253 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 379
Score = 70.9 bits (172), Expect = 2e-12
Identities = 81/289 (28%), Positives = 122/289 (42%), Gaps = 45/289 (15%)
Query: 17 VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQD 76
V K +TG SGIG T L L G V L RN E+E + ++ +
Sbjct: 83 VSGKTFAITGTTSGIGINTAEVLALAGAHVVLMNRNLH-----------ESENQKKRILE 131
Query: 77 EKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTK 136
+KP + K++ + DL+DL +V KA + + + LI NAGV TK
Sbjct: 132 KKP--------SAKVDIIFCDLSDLKTVRKAGEDYLAKNWPIHGLILNAGVFRPAAAKTK 183
Query: 137 DNFEIQMQTNYVSHFLLTMRLLPLI-KARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSM 195
D FE N V+HF L LLP++ ++ RV+ +SS + F + G M
Sbjct: 184 DGFESHYGVNVVAHFTLLRILLPVVRRSAPSRVVFLSSTLSSKHGFKKSMGIS----EKM 239
Query: 196 FFMWCRYALAKT-----ASIQFTKMLAIK------NPDILCMSLHPGLVMNTNLFSYCTR 244
+ + A T AS ++A K I S+HPG + T++F
Sbjct: 240 SILQGEDSSASTLQMYGASKMADMLIAFKLHRDEYKNGISTYSVHPGSGVRTDIFRNSLL 299
Query: 245 LPFVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDLSAETDNGAYF 293
F+G FV F + QGA +T+ CA ++ E +G Y+
Sbjct: 300 GKFIG--------FVTTPFTKNASQGAATTVYCATHPEV--EKISGKYW 338
>At1g64590 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 334
Score = 70.9 bits (172), Expect = 2e-12
Identities = 62/228 (27%), Positives = 103/228 (44%), Gaps = 40/228 (17%)
Query: 22 ALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHD 81
A++TG SGIG T L G ++ L R+ K AE + E P
Sbjct: 37 AIITGATSGIGAETARVLAKRGARLVLPARSV-----------KTAEETKARILSEFPDA 85
Query: 82 GLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEI 141
+++ +H+DL+ L SV + F L++LINNAG A + L++D E+
Sbjct: 86 EIIV--------MHLDLSSLTSVRRFVDDFESLNLPLNILINNAGKYAHKHALSEDGVEM 137
Query: 142 QMQTNYVSHFLLTMRLLPLI------KARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSM 195
TNY+ HFLLT LL + +GR++ V+S+ H+ G Y +
Sbjct: 138 TFATNYLGHFLLTKLLLKKMIETAAQTGVQGRIVNVTSVVHSWF-----SGDMLQYLADI 192
Query: 196 ------FFMWCRYALAKTA----SIQFTKMLAIKNPDILCMSLHPGLV 233
+ YAL+K A +++ +++L + ++ +HPG+V
Sbjct: 193 SRNNRNYDATRAYALSKLANVLHTVELSRLLHKMDANVTANCVHPGIV 240
>CE27908 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 319
Score = 69.7 bits (169), Expect = 6e-12
Identities = 68/278 (24%), Positives = 114/278 (40%), Gaps = 41/278 (14%)
Query: 17 VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQD 76
+ K +TG SGIG T L L G V + RN + + K +
Sbjct: 26 LSGKTFAITGTTSGIGVETAKALILKGAHVVMINRNYTASEASKKSL------------- 72
Query: 77 EKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTK 136
L+ +++ + DL L+SV+KAA ++ Q+ L LI NAGV + T
Sbjct: 73 ------LIETPNAQIDIVQCDLNSLSSVKKAADEYLEQKWPLHGLILNAGVFGPSEKTTS 126
Query: 137 DNFEIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSSLGHNLIFFNC-NPGAQF----- 189
D FE N+++HF+L LLP+++ + R++ V+S+ L C P ++
Sbjct: 127 DGFEAHFGINHLAHFILIKELLPVLRESAPSRIVIVTSM---LSKHTCVKPDSRIVEKLD 183
Query: 190 NYWPSMFFMWCRYALAKTASIQFTKMLAIKNPD----ILCMSLHPGLVMNTNLFSYCTRL 245
P W AK+ + + I ++HPG + T+L
Sbjct: 184 TLCPKEATQWYFRLYAKSKMCNILTAFKLHRDEFKNRISVYAVHPGSGVRTDLHR----- 238
Query: 246 PFVGIFFWILFQFVGYFFGVSNEQGAISTLKCALSSDL 283
W + F+ F + QGA ++L CA+ ++
Sbjct: 239 ---DFGLWSIADFLSIPFTKNASQGAATSLYCAVHPEV 273
>At4g24050 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 69.7 bits (169), Expect = 6e-12
Identities = 63/223 (28%), Positives = 101/223 (45%), Gaps = 30/223 (13%)
Query: 22 ALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHD 81
A++TG SGIG T L G ++ RN A + I E P
Sbjct: 37 AVITGATSGIGAETARVLAKRGARLIFPARNVKAAEEAKERIVSEF-----------PET 85
Query: 82 GLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEI 141
+++ K +DL+ + SV F + L++LINNAG +A + +++D E+
Sbjct: 86 EIVVMK--------LDLSSIASVRNFVADFESLDLPLNLLINNAGKLAHEHAISEDGIEM 137
Query: 142 QMQTNYVSHFLLTMRLL-PLIKAR-----KGRVITVSSLGHNLIFFNCNPGAQFNYWPSM 195
TNY+ HFLLT LL +I+ +GR++ V+S H + + P
Sbjct: 138 TFATNYLGHFLLTNLLLNKMIQTAEETGVQGRIVNVTSGIHGWFSGDLIEYLRLISQPKC 197
Query: 196 FFMWCR-YALAKTASIQFTKMLAIK----NPDILCMSLHPGLV 233
F R YAL+K A++ TK L+ + ++ +HPG+V
Sbjct: 198 QFDATRAYALSKLANVLHTKELSSRLQKIGANVTVNCVHPGVV 240
>Hs20149619 [Q] KOG1205 Predicted dehydrogenase
Length = 325
Score = 68.9 bits (167), Expect = 9e-12
Identities = 49/159 (30%), Positives = 75/159 (46%), Gaps = 18/159 (11%)
Query: 19 NKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEK 78
N V ++TG SG+G Y G K+ L GRN + I+E+ K Q K
Sbjct: 52 NAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTAS---HATKVQTHK 108
Query: 79 PHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGV--MAIPYELTK 136
P+ + DLTD ++ AA + ++D+L+NNAG+ + T
Sbjct: 109 PY------------LVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTV 156
Query: 137 DNFEIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSL 174
D + M+TNY LT LLP +IK R+G ++ +SS+
Sbjct: 157 DVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSI 195
>At4g09750 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 322
Score = 68.9 bits (167), Expect = 9e-12
Identities = 60/222 (27%), Positives = 97/222 (43%), Gaps = 31/222 (13%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
+++ K +VTG NSGIG+ L G VY+ RN R A+ +I+
Sbjct: 40 QIEGKNCVVTGANSGIGFAAAEGLASRGATVYMVCRNKERGQEALSKIQTS--------- 90
Query: 76 DEKPHDGLMIRKTGKLE-YLHI-DLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYE 133
TG YL + DL+ +N ++ A+ F ++ + VL+NNAG++
Sbjct: 91 ------------TGNQNVYLEVCDLSSVNEIKSFASSFASKDVPVHVLVNNAGLLENKRT 138
Query: 134 LTKDNFEIQMQTNYVSHFLLTMRLLPLIK--ARKGRVITVSSLGHNLIFFNCNPGAQFNY 191
T + FE+ N + + +T +LPL++ +VITV+S G + +
Sbjct: 139 TTPEGFELSFAVNVLGTYTMTELMLPLLEKATPDAKVITVASGG----MYTSPLTTDLQF 194
Query: 192 WPSMFFMWCRYALAKTASIQFTKMLA--IKNPDILCMSLHPG 231
F +YA K + T+ A KN I S+HPG
Sbjct: 195 SGEKFDGVEQYARNKRIQVALTEKWADKYKNKGIGFYSMHPG 236
>CE01219 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 329
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/158 (32%), Positives = 77/158 (48%), Gaps = 20/158 (12%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
K +VTG SGIG T L L+G V + RN E +L+K E+
Sbjct: 29 KTFVVTGTTSGIGIETARSLSLNGAHVVMLNRNL------------EESEKLKKKIVEEM 76
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNF 139
+D +++ + DL L+SV+KAA + ++ + LI NAGV + T D
Sbjct: 77 NDA-------EIDIIECDLNSLHSVKKAAEVYISKKWSIHCLILNAGVFGTASKTTVDGL 129
Query: 140 EIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSSLGH 176
E N++SHFLL LLP+++ + R++ VSS H
Sbjct: 130 ESHFAINHLSHFLLIQELLPIVRQSIPSRIVLVSSSVH 167
>CE28291 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 357
Score = 67.8 bits (164), Expect = 2e-11
Identities = 73/270 (27%), Positives = 118/270 (43%), Gaps = 35/270 (12%)
Query: 17 VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQD 76
+ K +TG SGIG T L L G V + RN E+E ++ ++
Sbjct: 34 LSGKTYAITGTTSGIGIETARALALKGAHVVMFNRNIV-----------ESEKLKKRIEE 82
Query: 77 EKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTK 136
EKP K++++ DL L S + AA +F + L LI NAGV A + T
Sbjct: 83 EKPDV--------KIDFISCDLNSLQSAKAAADEFLSKHWPLHGLILNAGVFAPTVKFTF 134
Query: 137 DNFEIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSSL--GHNLIFFNCNPGAQFNYW- 192
DNFE N+++ FLL LLP ++ + R++ VSS+ H + + N
Sbjct: 135 DNFESHFGVNHLAQFLLAKELLPALRQSSPARIVFVSSVSSSHTGLKAEMTRSEKLNKLC 194
Query: 193 --PSMFFMWCRYALAKTASIQFTKML---AIKNPDILCMSLHPGLVMNTNLFSYCTRLPF 247
+ F + YA +K + + + I ++HPG ++ T++ F
Sbjct: 195 PENANEFYYKLYAYSKMCQVLTAFKIHRDEFVSHGISTYAIHPGTMIGTDI---SRGFGF 251
Query: 248 VGIFFWILFQFVGYFFGVSNEQGAISTLKC 277
+G F+ IL + F S QGA +++ C
Sbjct: 252 LGKFWNILSK----PFTKSLAQGAATSVYC 277
>CE21092 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 65.5 bits (158), Expect = 1e-10
Identities = 62/229 (27%), Positives = 95/229 (41%), Gaps = 47/229 (20%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
+ +KVA++TG +SGIG T + L G KV + GR+S ++ + EI K
Sbjct: 3 RFSDKVAIITGSSSGIGRSTAVLLAQEGAKVTVTGRSSEKIQETVNEIHKNG-------- 54
Query: 76 DEKPHDGLMIRKTGKLEYLHIDLTDLNSVE--KAATKFTVQE-DHLDVLINNAGVM---- 128
G + ++I L DLN E K T+ +D+LINNAG
Sbjct: 55 -------------GSSDNINIVLGDLNESECQDELIKSTLSRFGKIDILINNAGAAFADP 101
Query: 129 --AIPYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPG 186
I E F+ M+ N S L + P + A KG ++ VSS+
Sbjct: 102 SGKIGSEAAIGIFDDMMKLNLRSVVELVKKCRPHLIASKGEIVNVSSIAAG--------- 152
Query: 187 AQFNYWPSMFFMWCRYALAKTASIQFTKMLAIK--NPDILCMSLHPGLV 233
P + + Y + K Q T+ LA++ D+ S+ PGL+
Sbjct: 153 ------PQPYIYYTYYGICKAGLDQLTRSLALELIPFDVRVNSVSPGLI 195
>Hs13375997 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 242
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/141 (38%), Positives = 69/141 (48%), Gaps = 6/141 (4%)
Query: 93 YLHI-DLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEIQMQTNYVSHF 151
+LHI DL+D + K F QE L VLINNAG M ELT+D E N + +
Sbjct: 45 FLHIVDLSDPKQIWKFVENFK-QEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVY 103
Query: 152 LLTMRLLPLI-KARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSMFFMWCRYALAKTASI 210
+LT L+P++ K RVITVSS G + N N Q P F YA K +
Sbjct: 104 ILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTN-DLQSERTP--FDGTMVYAQNKRQQV 160
Query: 211 QFTKMLAIKNPDILCMSLHPG 231
T+ A +P I S+HPG
Sbjct: 161 VLTERWAQGHPAIHFSSMHPG 181
>At5g61830 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 61.6 bits (148), Expect = 2e-09
Identities = 50/159 (31%), Positives = 74/159 (46%), Gaps = 28/159 (17%)
Query: 21 VALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPH 80
VA+VTG N GIG+ L +HG V L RN + A+K ++ + E
Sbjct: 38 VAVVTGSNRGIGFEIARQLAVHGLTVVLTARNVNAGLEAVKSLRHQEE------------ 85
Query: 81 DGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDN-- 138
GL K+ + +D+TD +S+ + LD+L+NNAGV Y L DN
Sbjct: 86 -GL------KVYFHQLDVTDSSSIREFGCWLKQTFGGLDILVNNAGV---NYNLGSDNTV 135
Query: 139 --FEIQMQTNYVSHFLLTMRLLPLIK--ARKGRVITVSS 173
E + TNY +T ++PL++ RV+ VSS
Sbjct: 136 EFAETVISTNYQGTKNMTKAMIPLMRPSPHGARVVNVSS 174
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 61.2 bits (147), Expect = 2e-09
Identities = 63/227 (27%), Positives = 95/227 (41%), Gaps = 41/227 (18%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
+ KVALVTG ++GIG T + L G KV + GRN+ R+ +EI K
Sbjct: 3 RFSGKVALVTGSSNGIGRATAVLLAQEGAKVTITGRNADRLEETRQEILKSG-------- 54
Query: 76 DEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVM------A 129
P D ++ T DL ++ + LD+L+NNAG
Sbjct: 55 --VPEDHVLSIAT--------DLATEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGR 104
Query: 130 IPYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQF 189
+ + ++ MQ N S LT + + KG V+ VSS+G P AQ
Sbjct: 105 VGVDQDVSVYDRIMQINMRSVVTLTQKAKEHLVKAKGEVVNVSSIG-------AGPQAQ- 156
Query: 190 NYWPSMFFMWCRYALAKTASIQFTKMLAIK--NPDILCMSLHPGLVM 234
P+ + YA++K A Q+T+ AI + S+ PG V+
Sbjct: 157 ---PTFMY----YAMSKAALDQYTRSAAIDLIQYGVRVNSVSPGAVV 196
>CE21095 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 61.2 bits (147), Expect = 2e-09
Identities = 63/228 (27%), Positives = 101/228 (43%), Gaps = 43/228 (18%)
Query: 15 PKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKG 74
P+ NK ++TG ++GIG T + G V + GR+S R +++ +I L+ G
Sbjct: 2 PRFSNKTVIITGSSNGIGRTTAILFAQEGANVTITGRSSER-------LEETRQIILKSG 54
Query: 75 QDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYEL 134
EK + ++ D+T + ++ Q +DVL+NNAG AIP
Sbjct: 55 VSEKQVNSVV-----------ADVTTEDGQDQIINSTLKQFGKIDVLVNNAGA-AIPDAF 102
Query: 135 ----TKDNFEIQMQT---NYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGA 187
T +I +T N + +T ++ P + A KG ++ VSS+ P A
Sbjct: 103 GTTGTDQGIDIYHKTLKLNLQAVIEMTKKVKPHLVASKGEIVNVSSI-------VAGPQA 155
Query: 188 QFNYWPSMFFMWCRYALAKTASIQFTKMLAI--KNPDILCMSLHPGLV 233
Q P + YA+AK A Q+T+ AI I S+ PG+V
Sbjct: 156 Q----PDFLY----YAIAKAALDQYTRSTAIDLAKFGIRVNSVSPGMV 195
>Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 387
Score = 60.8 bits (146), Expect = 3e-09
Identities = 47/164 (28%), Positives = 77/164 (46%), Gaps = 27/164 (16%)
Query: 17 VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQD 76
VD K LVTGG+ G+G+ +L GF V+ G N + +E+++ R
Sbjct: 80 VDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNEN--GPGAEELRRTCSPR------ 131
Query: 77 EKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFT--VQEDHLDVLINNAGVMAIPYE- 133
L L +D+T ++ A +K +Q+ L +INNAGV+ P +
Sbjct: 132 --------------LSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDG 177
Query: 134 --LTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLG 175
L +++ M N+ +T LPL++ KGR++ VSS+G
Sbjct: 178 ELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMG 221
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 60.8 bits (146), Expect = 3e-09
Identities = 61/223 (27%), Positives = 98/223 (43%), Gaps = 43/223 (19%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
KVA++TG ++GIG T + G KV + GR++ R+ ++I L G E+
Sbjct: 7 KVAIITGSSNGIGRATAVLFAREGAKVTITGRHAERLEETRQQI-------LAAGVSEQN 59
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTK--- 136
+ ++ T I T L K LD+L+NNAG AIP +K
Sbjct: 60 VNSVVADVTTDAGQDEILSTTLGKFGK-----------LDILVNNAGA-AIPDSQSKTGT 107
Query: 137 ----DNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQFNYW 192
++++ + N S LT + +P + + KG ++ +SS+ L + F Y
Sbjct: 108 AQSIESYDATLNLNLRSVIALTKKAVPHLSSTKGEIVNISSIASGL-----HATPDFPY- 161
Query: 193 PSMFFMWCRYALAKTASIQFTKMLAIK--NPDILCMSLHPGLV 233
Y++AK A Q+T+ AI I S+ PGLV
Sbjct: 162 ---------YSIAKAAIDQYTRNTAIDLIQHGIRVNSISPGLV 195
>Hs4502599 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 277
Score = 60.1 bits (144), Expect = 4e-09
Identities = 55/171 (32%), Positives = 80/171 (46%), Gaps = 25/171 (14%)
Query: 21 VALVTGGNSGIGYYTVLHLY-LHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
VALVTGGN GIG V L L V L R+ +R A+++++ E
Sbjct: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAE------------- 53
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNF 139
GL R + +D+ DL S+ + LDVL+NNAG+ + T +
Sbjct: 54 --GLSPR------FHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHI 105
Query: 140 --EIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQ 188
E+ M+TN+ + LLPLIK +GRV+ VSS+ +C+P Q
Sbjct: 106 QAEVTMKTNFFGTRDVCTELLPLIKP-QGRVVNVSSIMSVRALKSCSPELQ 155
>7292613 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 58.9 bits (141), Expect = 1e-08
Identities = 55/180 (30%), Positives = 83/180 (45%), Gaps = 25/180 (13%)
Query: 19 NKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEK 78
N+VA+VTG +SGIG L L G V R RV KE+++E
Sbjct: 6 NRVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRV----KELQRE------------ 49
Query: 79 PHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDN 138
L K GKL L+ D+ + +SV +A + +DVL+NNAG + Y + +
Sbjct: 50 ----LPAEKRGKLFALYCDVGNESSVNEAFDWIIQKLGAIDVLVNNAGTLQPGYLVDMNP 105
Query: 139 FEIQ--MQTNYVSHFLLTMRLLPLIKARK--GRVITVSS-LGHNLIFFNCNPGAQFNYWP 193
+Q +QTN + L T R + ++ RK G V+ ++S LGH + N +P
Sbjct: 106 AVMQQVLQTNIMGIVLCTQRAVRSMRERKFDGHVVLINSILGHKTMTATEGVAPDVNVYP 165
>CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 347
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/164 (32%), Positives = 78/164 (47%), Gaps = 19/164 (11%)
Query: 22 ALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHD 81
A+VTGG+ GIG+ + L G V + RN + A +++ A+ ++GQ +K H
Sbjct: 41 AIVTGGSKGIGFQLAVGLIERGCHVTIVARNVKDLEKACADLQVLAD---QRGQRQKVH- 96
Query: 82 GLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQE-DHLDVLINNAG--VMAIPYELTKDN 138
+ ID+T V K+A +E +D+LINNAG V A EL +
Sbjct: 97 -----------WKSIDMTGGYDVIKSAFDDAARELGPIDILINNAGHSVQAPFCELPITD 145
Query: 139 FEIQMQTNYVSHFLLTMRLLPLIKARK-GRVITVSSLGHNLIFF 181
FE QM NY+S T ++ +K RK G + VSS F
Sbjct: 146 FEKQMAVNYLSAVHATRAVVDDMKTRKTGHISFVSSAAGQFAIF 189
>7295621 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 57.8 bits (138), Expect = 2e-08
Identities = 60/222 (27%), Positives = 97/222 (43%), Gaps = 35/222 (15%)
Query: 19 NKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEK 78
N VA+VTG +SGIG L G V R R+ +E+ ++ RLR
Sbjct: 6 NCVAVVTGASSGIGAAITRKLISAGVMVVALARRMDRLEQLREELPQDRRSRLR------ 59
Query: 79 PHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTK-- 136
+ D++D++SV ++D+LINNAG ++ LT
Sbjct: 60 --------------IMQCDVSDVSSVNAVFDAVQGDLGNVDILINNAGKLSGGQLLTMSV 105
Query: 137 DNFEIQMQTNYVSHFLLTMRLLPLIKAR--KGRVITVSSL-GHNLIFFNCNPGAQ--FNY 191
D + +QTN + T R ++ R KG V+ ++S+ GH + FN PG+Q N
Sbjct: 106 DTVQQMLQTNVMGVVYCTQRAFESMRQRQSKGHVVLINSIVGHYI--FNPLPGSQQELNM 163
Query: 192 WPSMFFMWCRYALAKTASIQFTKMLAIKNPDILCMSLHPGLV 233
+P+ ++A+ + +M K + S+ PGLV
Sbjct: 164 YPA-----TKHAITALTELFRQEMRDFKT-KVKVTSISPGLV 199
>CE15574 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 57.4 bits (137), Expect = 3e-08
Identities = 58/213 (27%), Positives = 92/213 (42%), Gaps = 45/213 (21%)
Query: 15 PKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKG 74
P+ KVALVTG ++GIG T + L G KV + GRN+ R+ +EI LR G
Sbjct: 2 PRFSGKVALVTGSSNGIGRATAILLAREGAKVTITGRNAQRLEETKQEI-------LRSG 54
Query: 75 QDEKPHDGL---MIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIP 131
E + + ++G++E ++ + LD+L+NNAG
Sbjct: 55 VPEDHVLSIIADLATESGQIELMNSTVDIFG--------------RLDILVNNAGAAITD 100
Query: 132 YE------LTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNP 185
E F+ M+ N S LT + + KG ++ VSS+
Sbjct: 101 LEGHIGVGTNVSVFDKTMRINLRSVVTLTQKAKEHLIKTKGEIVNVSSIA---------- 150
Query: 186 GAQFNYWPSMFFMWCRYALAKTASIQFTKMLAI 218
G Q + P + + YA++K+A Q+T+ AI
Sbjct: 151 GGQ-HAQPELIY----YAMSKSALDQYTRSAAI 178
>CE06649 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 57.0 bits (136), Expect = 4e-08
Identities = 61/242 (25%), Positives = 107/242 (44%), Gaps = 44/242 (18%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
+ KV L++G + GIG T + G K+ L GR++ +++K ++ + G
Sbjct: 5 RFSGKVVLISGSSKGIGQATAVKFAAEGAKIVLNGRSAD-------DVEKTRKLCMEVG- 56
Query: 76 DEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIP---- 131
KP D ++ G D+T+ + V+ LD+LINNAG + +
Sbjct: 57 -AKPWD--LLPTVG-------DITNEDFVKMMVNTVIHNFGKLDILINNAGTLEVDMTGK 106
Query: 132 --YELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQF 189
+E+ D + +N+ S +LT +P + KG ++ VS+ F + P
Sbjct: 107 EGWEMGVDVMDRSWNSNFKSVLMLTQAAMPHLIKTKGDIVNVST------FLSSGPIGVM 160
Query: 190 NYWPSMFFMWCRYALAKTASIQFTKMLAIKN--PDILCMSLHPGLVMNTNLFSYCTRLPF 247
SM + YA+ K A Q ++ +A + + +++PGLV S+ RLP
Sbjct: 161 ----SMPY----YAVPKAALDQMSRSMAHEYMLKGVRLNTVNPGLVST----SFFARLPG 208
Query: 248 VG 249
VG
Sbjct: 209 VG 210
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 56.2 bits (134), Expect = 6e-08
Identities = 58/225 (25%), Positives = 94/225 (41%), Gaps = 43/225 (19%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLY-LHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKG 74
++D K L+TG +SGIG T + + K+ L R S V KE++ + E+ +
Sbjct: 3 RLDGKTILITGASSGIGKSTAFEIAKVAKVKLILAARRFSTVEEIAKELESKYEVSVLP- 61
Query: 75 QDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMA---IP 131
L +D++DL S+ + +DVLINNAG+
Sbjct: 62 -------------------LKLDVSDLKSIPGVIESLPKEFADIDVLINNAGLALGTDKV 102
Query: 132 YELTKDNFEIQMQTNYVSHFLLTMRLLPLIKAR-KGRVITVSSLGHNLIFFNCNPGAQFN 190
+L D+ + TN + +T +LP+ ++ KG ++ V S+ G +
Sbjct: 103 IDLNIDDAVTMITTNVLGMMAMTRAVLPIFYSKNKGDILNVGSIA----------GRESY 152
Query: 191 YWPSMFFMWCRYALAKTASIQFTKMLAIKNPD--ILCMSLHPGLV 233
S+ Y K+A QFT L + D I M + PGLV
Sbjct: 153 VGGSV------YCSTKSALAQFTSALRKETIDTRIRIMEVDPGLV 191
>Hs7706318 [Q] KOG1205 Predicted dehydrogenase
Length = 339
Score = 55.5 bits (132), Expect = 1e-07
Identities = 49/163 (30%), Positives = 86/163 (52%), Gaps = 22/163 (13%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
++ + V VTG +SGIG L G + L S+R H ++ +K+ R +
Sbjct: 47 ELTDMVVWVTGASSGIGEELAYQLSKLGVSLVL----SARRVHELERVKR----RCLENG 98
Query: 76 DEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQE-DHLDVLINNAGV--MAIPY 132
+ K D L+ L +DLTD S E AATK +QE +D+L+NN G+ ++
Sbjct: 99 NLKEKDILV---------LPLDLTDTGSHE-AATKAVLQEFGRIDILVNNGGMSQRSLCM 148
Query: 133 ELTKDNFEIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSL 174
+ + D + ++ NY+ LT +LP +I+ ++G+++TV+S+
Sbjct: 149 DTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSI 191
>CE20000 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 315
Score = 55.5 bits (132), Expect = 1e-07
Identities = 46/157 (29%), Positives = 71/157 (44%), Gaps = 24/157 (15%)
Query: 17 VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQD 76
V K +TG SGIG T L L G V L RN + +E + RK +
Sbjct: 25 VAGKTYAITGTTSGIGVDTAEVLALAGAHVVLINRNL-----------RASETQKRKILE 73
Query: 77 EKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTK 136
+KP K++ ++ DL+DL + KA ++ ++ + LI NAGV TK
Sbjct: 74 KKPD--------AKVDIIYCDLSDLKTARKAGEEYLKKKWPIHGLILNAGVFQPAVAKTK 125
Query: 137 DNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSS 173
D E N ++HF + +RL + R++ +SS
Sbjct: 126 DGLESHFGVNVLAHFTVMVRL-----SAPSRIVILSS 157
>7301818 [Q] KOG1205 Predicted dehydrogenase
Length = 326
Score = 55.5 bits (132), Expect = 1e-07
Identities = 43/178 (24%), Positives = 77/178 (43%), Gaps = 25/178 (14%)
Query: 1 MWEEFDITKLPYYDPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAI 60
+W+ F K + ++ KV L+TG +SG+G Y G +V L R + +
Sbjct: 38 IWQRFQAQK---FRNQLPGKVVLITGASSGLGESLAHVFYRAGCRVILAARRTQELERVK 94
Query: 61 KEIKKEAEIRLRKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDV 120
K++ L + L +DL +LNS+ + T+ + +D+
Sbjct: 95 KDLL-----------------ALDVDPAYPPTVLPLDLAELNSIPEFVTRVLAVYNQVDI 137
Query: 121 LINNAGVMAIPYELTKDNFEIQ---MQTNYVSHFLLTMRLLP-LIKARKGRVITVSSL 174
LINN G+ ++ ++ ++ M NY LT LLP ++K G + +SS+
Sbjct: 138 LINNGGI-SVRADVASTAVDVDLKVMVVNYFGSVALTKALLPSMVKRGSGHICFISSV 194
>CE27376 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/158 (29%), Positives = 65/158 (41%), Gaps = 19/158 (12%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFK-VYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEK 78
+ L+TG GIG T L L H V + GR + I KE
Sbjct: 39 RTILITGATDGIGKQTALDLAAHPDNFVIIHGRTEEKCIATKDWIGKENG---------- 88
Query: 79 PHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDN 138
++Y+ D L V A + + L+VL+ NAGV+ TKD
Sbjct: 89 --------NCSNIDYVAGDFAVLKEVAIIAEEVERRFPELNVLLCNAGVLYPRRLETKDG 140
Query: 139 FEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGH 176
E Q NY++H+LL LLP++ + VI V S+ H
Sbjct: 141 MESTFQVNYLAHYLLCNLLLPVLSHNRSNVIVVGSVLH 178
>CE21093 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 281
Score = 55.1 bits (131), Expect = 1e-07
Identities = 57/220 (25%), Positives = 87/220 (38%), Gaps = 61/220 (27%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKE--------- 66
+ KVALVTG ++GIG + G KV + GRN+ R+ +EI K
Sbjct: 4 RFSGKVALVTGSSNGIGRAAAVLFAKDGAKVTVTGRNAERLEETRQEILKSGVPESHVLS 63
Query: 67 --AEIRLRKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINN 124
++ KGQDE + I+K G+ LD+L+NN
Sbjct: 64 VATDLAAEKGQDELVNS--TIQKFGR---------------------------LDILVNN 94
Query: 125 AGVM------AIPYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNL 178
AG + + ++ MQ N S LT + + KG ++ VSS+
Sbjct: 95 AGAAFNDDQGRVGVDQDVSVYDKIMQINMRSVVTLTQKAKEHLVKAKGEIVNVSSIAGTA 154
Query: 179 IFFNCNPGAQFNYWPSMFFMWCRYALAKTASIQFTKMLAI 218
+ PG + YA++K+A QFT+ AI
Sbjct: 155 ---HAQPGVMY------------YAMSKSALDQFTRCAAI 179
>CE27260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 206
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/204 (28%), Positives = 87/204 (41%), Gaps = 42/204 (20%)
Query: 21 VALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPH 80
VA+VTG +SGIG L L + +K+ L GRN + +N +I + G D+
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQI-------VSAGSDKND- 54
Query: 81 DGLMIRKTGKLEYLHIDLTDLNSVE--KAATKFTVQE-DHLDVLINNAGVMAIPYELTK- 136
+ + +L S E K TVQ+ +D LIN+AG++ L
Sbjct: 55 -------------VLVTAVELASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSG 101
Query: 137 -DNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSM 195
+ ++ M N S LT LP I KG V+ VSS+ P
Sbjct: 102 IEVYDELMNVNVRSLIRLTRAALPHIITTKGTVVNVSSIN----------------GPCP 145
Query: 196 FFMWCRYALAKTASIQFTKMLAIK 219
F Y ++K+A QFTK LA++
Sbjct: 146 FAGVTYYCMSKSAVDQFTKCLALE 169
>CE27259 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 501
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/204 (28%), Positives = 87/204 (41%), Gaps = 42/204 (20%)
Query: 21 VALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPH 80
VA+VTG +SGIG L L + +K+ L GRN + +N +I + G D+
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQI-------VSAGSDKND- 54
Query: 81 DGLMIRKTGKLEYLHIDLTDLNSVE--KAATKFTVQE-DHLDVLINNAGVMAIPYELTK- 136
+ + +L S E K TVQ+ +D LIN+AG++ L
Sbjct: 55 -------------VLVTAVELASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSG 101
Query: 137 -DNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSM 195
+ ++ M N S LT LP I KG V+ VSS+ F N
Sbjct: 102 IEVYDELMNVNVRSLIRLTRAALPHIITTKGTVVNVSSINGPCPFPNVT----------- 150
Query: 196 FFMWCRYALAKTASIQFTKMLAIK 219
Y ++K+A QFTK LA++
Sbjct: 151 -----YYCMSKSAVDQFTKCLALE 169
>At5g04070 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 327
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/175 (28%), Positives = 80/175 (45%), Gaps = 29/175 (16%)
Query: 21 VALVTGGNSGIGYYTVLHLYLHGFKVYL-----------GGRNS-SRVNHAIKEIKKEAE 68
V ++TG SG+G T L GF V L G R R + + +IK++ E
Sbjct: 42 VCVITGATSGLGKATAFALSRKGFYVVLAESFLLILQLDGPRTYYQRFSTTLSDIKRQNE 101
Query: 69 -IRLRKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGV 127
+L+ + + L+++ LE + +DL+S + +L+NNAG+
Sbjct: 102 DAKLKAFEVDMSSFQLVLKFRSSLEQWLFE-SDLHS-------------SVQLLVNNAGI 147
Query: 128 MAIPYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKAR--KGRVITVSSLGHNLIF 180
+A T + F+ + TNYV F LT LLPL++ RV+ V+S H F
Sbjct: 148 LATSSRPTVEGFDRMIATNYVGAFSLTKLLLPLLRNSPVPSRVVNVTSFTHRSAF 202
>CE07544 [Q] KOG1205 Predicted dehydrogenase
Length = 262
Score = 54.3 bits (129), Expect = 2e-07
Identities = 51/177 (28%), Positives = 78/177 (43%), Gaps = 27/177 (15%)
Query: 15 PKVD--NKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLR 72
PK+D NKV ++TG +SG+G LY G +V L R++ + +KEI +E +
Sbjct: 41 PKLDVKNKVVVITGASSGLGKSLAFELYKRGAQVILLARSTEK----LKEICEELKETFP 96
Query: 73 KGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGV--MAI 130
Q+E Y + D+TD A + +D+LINNAG+
Sbjct: 97 LNQNEP-------------IYYYFDITDSEQAPWA------EIPRVDILINNAGMSNRGS 137
Query: 131 PYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGA 187
+ T + M+TNY H +T LL + V+T S G I + + GA
Sbjct: 138 CQDTTMEIHRQAMETNYFGHVHVTQALLSKLSPDGCIVVTSSIQGKVAIPYRGSYGA 194
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 54.3 bits (129), Expect = 2e-07
Identities = 63/225 (28%), Positives = 99/225 (44%), Gaps = 45/225 (20%)
Query: 19 NKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEK 78
+KVA++TG ++GIG T L G KV + GRN+ R +++ I L G E
Sbjct: 6 DKVAIITGSSNGIGQATARLLASEGAKVTVTGRNAER-------LEETKNILLGAGVPE- 57
Query: 79 PHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQE-DHLDVLINNAGVMAIPYELTK- 136
G + + D+T SV++ K T+ + +D+L+NNAG IP K
Sbjct: 58 ----------GNVLVVVGDITQ-ESVQENLIKSTLDKFGKIDILVNNAGA-GIPDAQGKS 105
Query: 137 ------DNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQFN 190
D + + N S +T + P + +G ++ +SS+G P AQ
Sbjct: 106 GVNQSIDTYHKTFELNVQSVIEMTQKARPHLAKTQGEIVNISSIG-------AGPAAQV- 157
Query: 191 YWPSMFFMWCRYALAKTASIQFTKMLAIK--NPDILCMSLHPGLV 233
S + Y++AK A Q+T+ AI I S+ PG V
Sbjct: 158 --ASPY-----YSIAKAALDQYTRTAAIDLVPEGIRVNSVSPGAV 195
>CE26808_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 550
Score = 54.3 bits (129), Expect = 2e-07
Identities = 64/214 (29%), Positives = 87/214 (39%), Gaps = 49/214 (22%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKE---AEIRLR 72
+ KVALVTG ++GIG L G KV + GRN+ R+ + I K AE L
Sbjct: 218 RFSGKVALVTGSSNGIGRAAALLFAQQGAKVTITGRNAERLEETRQAILKSGVPAENVLA 277
Query: 73 KGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGV----- 127
D G TDL + KF LD+L+NNAG
Sbjct: 278 IAADLATDQG---------------QTDL--INGTLQKF----GRLDILVNNAGAAVNDP 316
Query: 128 ---MAIPYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCN 184
M I ++ ++F+ Q N S L + + KG +I VSS+G
Sbjct: 317 QGRMGIDQQI--EDFDKTFQINMRSVVTLVQKAKEHLIKTKGEIINVSSIGG-------G 367
Query: 185 PGAQFNYWPSMFFMWCRYALAKTASIQFTKMLAI 218
P AQ P M + Y ++K A QFT+ AI
Sbjct: 368 PHAQ----PDMMY----YGMSKAALDQFTRSTAI 393
>Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 343
Score = 53.5 bits (127), Expect = 4e-07
Identities = 45/160 (28%), Positives = 72/160 (44%), Gaps = 18/160 (11%)
Query: 17 VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQD 76
V +K LVTG +SG G+ HL+ GF V+ G + + +KE+ RLR Q
Sbjct: 53 VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ- 111
Query: 77 EKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAI-PYELT 135
L + + ++E + VE + E + L+NNAG+ E T
Sbjct: 112 ------LNVCSSEEVEKV---------VEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFT 156
Query: 136 K-DNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSL 174
+ ++ + N +T LPLI+ KGRV+ +SS+
Sbjct: 157 SLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSM 196
>At3g59710 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 302
Score = 53.5 bits (127), Expect = 4e-07
Identities = 45/160 (28%), Positives = 73/160 (45%), Gaps = 25/160 (15%)
Query: 18 DNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDE 77
+ A+VTG N GIG+ V L G V L RN+ + A + +++
Sbjct: 27 EETTAVVTGANKGIGFAVVKRLLELGLTVVLTARNAENGSQAAESLRRIG---------- 76
Query: 78 KPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVM--AIPYELT 135
G + + +D++D +S+ A+ F LD+L+NNA V A+ L
Sbjct: 77 ----------FGNVHFCCLDISDPSSIAAFASWFGRNLGILDILVNNAAVSFNAVGENLI 126
Query: 136 KDNFEIQMQTNYVSHFLLTMRLLPLIK--ARKGRVITVSS 173
K+ E ++TN+ LLT LLPL + R++ +SS
Sbjct: 127 KEP-ETIIKTNFYGAKLLTEALLPLFRRSVSVSRILNMSS 165
>At1g03630 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 401
Score = 53.5 bits (127), Expect = 4e-07
Identities = 48/163 (29%), Positives = 70/163 (42%), Gaps = 28/163 (17%)
Query: 22 ALVTGGNSGIGYYTVLHLYLHG-FKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPH 80
A++TG +SG+G T L G + V + RN + A + + E
Sbjct: 92 AVITGASSGLGLATAKALADTGKWHVIMACRNFLKAEKAARSVGMSKE------------ 139
Query: 81 DGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGV---MAIPYELTKD 137
+H+DL L SV++ F E LDVL+ NA V A T +
Sbjct: 140 ---------DYTVMHLDLASLESVKQFVENFRRTEQPLDVLVCNAAVYQPTAKEPSFTAE 190
Query: 138 NFEIQMQTNYVSHFLLTMRLLPLIKAR---KGRVITVSSLGHN 177
FEI + TN++ HFLL+ LL +K R+I V S+ N
Sbjct: 191 GFEISVGTNHLGHFLLSRLLLDDLKKSDYPSKRMIIVGSITGN 233
>HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 53.1 bits (126), Expect = 5e-07
Identities = 47/157 (29%), Positives = 76/157 (47%), Gaps = 13/157 (8%)
Query: 31 IGYYTVLHLY--------LHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHDG 82
+G Y +LH Y L V++ G +S +++ L EK +
Sbjct: 9 VGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQ 68
Query: 83 LMIRKTGKLEYLHIDLTDLNSVEKAA--TKFTVQEDHLDVLINNAGVM--AIPYEL-TKD 137
L + + +LE + +D+T SV AA K V++ L L+NNAG+ P EL TK
Sbjct: 69 LRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQ 128
Query: 138 NFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSL 174
+F + N + +T+ LLPL++ +GRV+ VSS+
Sbjct: 129 DFVTILDVNLLGVIDVTLSLLPLVRKARGRVVNVSSV 165
>Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 319
Score = 53.1 bits (126), Expect = 5e-07
Identities = 42/138 (30%), Positives = 70/138 (50%), Gaps = 5/138 (3%)
Query: 46 VYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVE 105
+++ G +S N A + K+ + E L + +L + +D+TD +V+
Sbjct: 32 IFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVK 91
Query: 106 KAA--TKFTVQEDHLDVLINNAGVMAI--PYE-LTKDNFEIQMQTNYVSHFLLTMRLLPL 160
+ A K V E L LINNAGV + P + LT +++ ++ N +T+ +LPL
Sbjct: 92 RTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPL 151
Query: 161 IKARKGRVITVSSLGHNL 178
+K +GRVI VSS+G L
Sbjct: 152 VKKAQGRVINVSSVGGRL 169
>At1g62610 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 307
Score = 53.1 bits (126), Expect = 5e-07
Identities = 46/165 (27%), Positives = 77/165 (45%), Gaps = 24/165 (14%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
++ +KV LVTG +SGIG L L G K+ R R+N EI I ++
Sbjct: 43 ELKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAAA 102
Query: 76 DEKPHDGLMIRKTGKLEYLHIDL-TDLNSVEKAATKFTVQEDHLDVLINNAGV---MAIP 131
L +D+ +D +++ KA + +DVLINNAG+ +
Sbjct: 103 ------------------LELDVSSDADTIRKAVKEAWEIFGTIDVLINNAGIRGNVKSS 144
Query: 132 YELTKDNFEIQMQTNYVSHFLLTMRLLPLIK--ARKGRVITVSSL 174
+L+K+ ++ +TN +L++ + L++ R G VI VSS+
Sbjct: 145 LDLSKEEWDKVFRTNLTGSWLISKYVCLLMRDAKRGGSVINVSSI 189
>CE20922 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 333
Score = 52.8 bits (125), Expect = 7e-07
Identities = 57/232 (24%), Positives = 99/232 (42%), Gaps = 38/232 (16%)
Query: 23 LVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHDG 82
L+TGG GIG L L ++ + GR+ ++ I + + + R
Sbjct: 53 LITGGTDGIGREAALKLAAEQHEITISGRDPNKAKDVIGQCQMKFNNTPR---------- 102
Query: 83 LMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDNFEIQ 142
++ DL+ + V K A++ V E+ D+ I NAGVM T+++ E
Sbjct: 103 ----------FIQTDLSLEHEVIKFASQ--VAEEQFDICILNAGVMNPKPGRTREDREAT 150
Query: 143 MQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNP-GAQFNYWPSMFFMW-- 199
M TN VS +++ +++ + + + V S + F N P G +F + P W
Sbjct: 151 MMTNLVSSYMIAHKIIDSRRDDQRSLHFVFSTSILVKFHNATPLGIRF-FNPEKVTDWQK 209
Query: 200 ----------CRYALAKTASIQFTKMLAIKN-PDILCMSLHPGLVMNTNLFS 240
+YA++K + ++ N P+I S+HPG V TN+ S
Sbjct: 210 SLVPTDVSGAGKYAISKIGLATLSTSISQCNLPNITATSVHPGTVY-TNIMS 260
>CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 52.8 bits (125), Expect = 7e-07
Identities = 67/235 (28%), Positives = 102/235 (42%), Gaps = 51/235 (21%)
Query: 23 LVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHDG 82
+VTG N GIG V L + +N + ++++K E++ K D + H
Sbjct: 7 VVTGANRGIGLGLVQQL--------VKDKNIRHIIATARDVEKATELKSIK--DSRVH-- 54
Query: 83 LMIRKTGKLEYLHIDLTDLNSVEKAATKF--TVQEDHLDVLINNAGVMAIPYELTKDNFE 140
L + +T S++ +K V D L +LINNAGV+ T+ N
Sbjct: 55 ----------VLPLTVTCDKSLDTFVSKVGEIVGSDGLSLLINNAGVLLSYGTNTEPNRA 104
Query: 141 I---QMQTNYVSHFLLTMRLLPLIK------------ARKGRVITVSSLGHNLIFFNCNP 185
+ Q+ N S LLT +LLPL+K + VIT+SS G I N +
Sbjct: 105 VIAEQLDVNTTSVVLLTQKLLPLLKNAASKESGDQLSVSRAAVITISS-GLGSITDNTSG 163
Query: 186 GAQFNYWPSMFFMWCRYALAKTASIQFTKMLAI--KNPDILCMSLHPGLVMNTNL 238
AQF Y ++K A F + LA+ K+ ++L ++ PG V TNL
Sbjct: 164 SAQFPV--------LAYRMSKAAINMFGRTLAVDLKDDNVLVVNFCPGWV-QTNL 209
>At3g61220 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 52.8 bits (125), Expect = 7e-07
Identities = 48/179 (26%), Positives = 73/179 (39%), Gaps = 46/179 (25%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
+ A+VTG N GIG+ L G +V L R+ +R A++ +KKE EI
Sbjct: 7 RYAVVTGANRGIGFEICRQLASEGIRVVLTSRDENRGLEAVETLKKELEI---------- 56
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAI--------- 130
L + +D+ D S+ A Q LD+L+NNAG+ I
Sbjct: 57 -------SDQSLLFHQLDVADPASITSLAEFVKTQFGKLDILVNNAGIGGIITDAEALRA 109
Query: 131 ---------------PYELTKDNFEIQMQTNYVSHFLLTMRLLPLIK-ARKGRVITVSS 173
YELT++ +I NY + +PL+K + R++ VSS
Sbjct: 110 GAGKEGFKWDEIITETYELTEECIKI----NYYGPKRMCEAFIPLLKLSDSPRIVNVSS 164
>7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 335
Score = 52.8 bits (125), Expect = 7e-07
Identities = 52/164 (31%), Positives = 75/164 (45%), Gaps = 20/164 (12%)
Query: 16 KVDNK-VALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKG 74
KVD++ V L+TG +SG+G H VY V IK E L+
Sbjct: 22 KVDSRHVVLITGCDSGLG---------HSMAVYCHESLHMTVISCCHNIKSEGAKLLQGL 72
Query: 75 QDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQED--HLDVLINNAGVMAI-- 130
K DGL T +L+ L D + V + ++ L LINNAGVM
Sbjct: 73 ASAK--DGLSRMHTLELDLLEPD--SIRLVHRQLRDILAKDPSYRLTALINNAGVMCFGE 128
Query: 131 -PYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSS 173
++LT + E Q+ N + LT LLPL++ ++GR+I V+S
Sbjct: 129 FEWQLT-EQIEAQINCNLLGTMRLTHELLPLLRQQQGRIINVTS 171
>7295622 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 52.8 bits (125), Expect = 7e-07
Identities = 50/166 (30%), Positives = 77/166 (46%), Gaps = 25/166 (15%)
Query: 19 NKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEK 78
++VA+VTG +SGIG HL G V R R+ K IK++ L+
Sbjct: 6 DRVAVVTGASSGIGAAVARHLVSAGVIVVGLARRVDRM----KAIKEQLPPELQ------ 55
Query: 79 PHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDN 138
G+L +H D+ DL+SV A Q D+L+NNAG + LT +
Sbjct: 56 ----------GRLHAIHCDVEDLDSVTAAFDWIEEQLGGCDILVNNAGCLNPGQLLTLEL 105
Query: 139 FEIQ--MQTNYVSHFLLTMRLLPLIKARK--GRVITVSSL-GHNLI 179
++Q + N + + T R ++ R+ G VI ++SL G N+I
Sbjct: 106 EQLQQVLNVNLMGVVICTRRAFRSMQQREVDGHVILINSLTGRNII 151
>CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 249
Score = 52.4 bits (124), Expect = 9e-07
Identities = 61/226 (26%), Positives = 97/226 (41%), Gaps = 37/226 (16%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
K L+TG N GIG LG +K+ K ++++ G P
Sbjct: 4 KSILITGANRGIG---------------LG---------LLKQFIKNKDVQIIIGTCRDP 39
Query: 80 HDGLMIR--KTGKLEYLHIDLTDLNSVEK--AATKFTVQEDHLDVLINNAGVMAIPYEL- 134
+ + K ++ L +D+ +S+ K A + V ED L VLINNAG+ +PY++
Sbjct: 40 SNATELNSIKDTRVHILQLDIDCDDSIRKLGAEVEKLVGEDGLTVLINNAGIF-VPYDID 98
Query: 135 ---TKDNFEIQMQTNYVSHFLLTMRLLPLIK--ARKGRVITVSSLGHNLIFFNCNPGAQF 189
++ Q++TN +S L+T LLPL+K A K R S +I + G+
Sbjct: 99 GEKSRSTLIRQLETNTISTVLITQELLPLLKRAAAKNRGEGYSINRSAIINISSTAGSIT 158
Query: 190 NYWPSMFFMWCRYALAKTASIQFTKMLAI--KNPDILCMSLHPGLV 233
S Y ++K+A F K ++ IL + PG V
Sbjct: 159 KIDASYNIPLVAYRMSKSALNSFGKSCSVDLAKYHILVTTFCPGWV 204
>7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 321
Score = 52.0 bits (123), Expect = 1e-06
Identities = 45/161 (27%), Positives = 72/161 (43%), Gaps = 23/161 (14%)
Query: 17 VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQD 76
+ +VA+VTG G+G L L G + + N S +K+I+ ++R + +
Sbjct: 50 IAGEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDIYKVRAKAYKA 109
Query: 77 EKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTK 136
+ + DL +LNS K + + VL+NNAGVM
Sbjct: 110 NVTN--------------YDDLVELNS------KVVEEMGPVTVLVNNAGVMMHRNMFNP 149
Query: 137 DNFEIQM--QTNYVSHFLLTMRLLPLIK-ARKGRVITVSSL 174
D ++Q+ N SHF + LP +K RKG ++T+SSL
Sbjct: 150 DPADVQLMINVNLTSHFWTKLVFLPKMKELRKGFIVTISSL 190
>7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 325
Score = 52.0 bits (123), Expect = 1e-06
Identities = 52/231 (22%), Positives = 94/231 (40%), Gaps = 43/231 (18%)
Query: 17 VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQD 76
+ +V L+TGG G+G L+ ++ + N + IK ++ + G D
Sbjct: 54 ISGQVVLITGGGGGVGRLIALNFARLQARIVIWDINQ-------EAIKTTVDLLAKHGYD 106
Query: 77 EKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIP--YEL 134
+ +D++D + + A++ T + +D+LINNAG++ +EL
Sbjct: 107 N-------------CKGYVVDISDREQIYQRASQVTEEVGPVDILINNAGIVCCKPFWEL 153
Query: 135 TKDNFEIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSLGHNLIFFNCNPGAQFNYWP 193
+ N +SH+ LP +++ +G ++TV S+ L + C+
Sbjct: 154 HDRVIQNTYNINIISHYWTVKAFLPHMMRNNRGHIVTVGSVTGMLGTYGCSD-------- 205
Query: 194 SMFFMWCRYALAKTASIQFTKM----LAIKNPDILCMSLHPGLVMNTNLFS 240
YA K A I F + L D + MSL +NT +FS
Sbjct: 206 --------YAATKYACIGFHESLLTDLKAHGYDQIQMSLICPYYINTGMFS 248
>At4g27440 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 401
Score = 51.6 bits (122), Expect = 2e-06
Identities = 53/183 (28%), Positives = 75/183 (40%), Gaps = 34/183 (18%)
Query: 8 TKLPYYDPKVDNKVAL------VTGGNSGIGYYTVLHLYLHG-FKVYLGGRNSSRVNHAI 60
T P VD K L VTG +SG+G T L G + V + R+ + A
Sbjct: 71 TSSPTVTKSVDGKKTLRKGNVVVTGASSGLGLATAKALAETGKWNVIMACRDFLKAERAA 130
Query: 61 KEIKKEAEIRLRKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDV 120
K + P D + +H+DL L+SV + F E LDV
Sbjct: 131 KSVGM-------------PKDSYTV--------MHLDLASLDSVRQFVDNFRRTETPLDV 169
Query: 121 LINNAGV---MAIPYELTKDNFEIQMQTNYVSHFLLTMRLLPLIKAR---KGRVITVSSL 174
L+ NA V A + + FE+ + TN++ HFLL LL +K R+I V S+
Sbjct: 170 LVCNAAVYFPTAKEPTYSAEGFELSVATNHLGHFLLARLLLDDLKKSDYPSKRLIIVGSI 229
Query: 175 GHN 177
N
Sbjct: 230 TGN 232
>Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/166 (26%), Positives = 81/166 (48%), Gaps = 17/166 (10%)
Query: 31 IGYYTVLHLY--------LHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKPHDG 82
+G Y +LH Y L V++ G +S N +++ L EK +
Sbjct: 9 VGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQ 68
Query: 83 LMIRKTGKLEYLHIDLTDLNSVEKAA--TKFTVQEDHLDVLINNAGVMAIPYEL-----T 135
L + + +LE + +D+T + S+ A K V + L L+NNAG++ P L T
Sbjct: 69 LRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILT-PITLCEWLNT 127
Query: 136 KDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFF 181
+D+ + ++ N + +T+ +LPL++ +GR++ VSS+ + FF
Sbjct: 128 EDSMNM-LKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFF 172
>Hs4502601 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 277
Score = 50.8 bits (120), Expect = 3e-06
Identities = 49/176 (27%), Positives = 80/176 (44%), Gaps = 31/176 (17%)
Query: 19 NKVALVTGGNSGIGYYTVLHLYLH-GFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDE 77
++VALVTG N GIG L V L R+ +R A+++++ E
Sbjct: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE----------- 53
Query: 78 KPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVM-----AIPY 132
GL R + +D+ DL S+ + L+VL+NNA V +P+
Sbjct: 54 ----GLSPR------FHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF 103
Query: 133 ELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQ 188
++ E+ ++TN+ + + LLP++K GRV+ +SSL F NC+ Q
Sbjct: 104 DI---KAEMTLKTNFFATRNMCNELLPIMKPH-GRVVNISSLQCLRAFENCSEDLQ 155
>SPAC19A8.06 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 397
Score = 50.4 bits (119), Expect = 3e-06
Identities = 66/266 (24%), Positives = 114/266 (42%), Gaps = 44/266 (16%)
Query: 13 YDPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLR 72
++ K++ V +VTGG+SGIG V L G +V I LR
Sbjct: 69 WERKMNGMVVMVTGGSSGIGQVVVEKLASLGAQVV---------------------ILLR 107
Query: 73 KGQDEKPHDGLM-IRKTGKLEYLHIDLTDLN---SVEKAATKF--TVQEDHLDVLINNAG 126
D+ D +M +RK K + ++ ++ DL+ SV K ATK+ LD+++ +G
Sbjct: 108 TEPDQFTVDYIMDLRKRTKNQLIYTEVCDLSSMLSVRKFATKWIDCTPIRRLDMIVLCSG 167
Query: 127 VMAIPY---ELTKDNFEIQMQTNYVSHFLLTMRLLPLIKARKG----RVITVSSLGHNLI 179
V+ P+ + T++ E+Q TN++ + L L P+I + G R++ + + L
Sbjct: 168 VLLPPFMDRQTTEEGVELQWATNFLGPYQLLRILRPVIYGQPGHREVRIVAATCSSYILG 227
Query: 180 FFNCNPGAQFNYWPSMFFMWCRYALAKTASIQF-----TKMLAIKNPDILCMSLH----- 229
+ N N+ W AK A + + K A + PD + +LH
Sbjct: 228 NIDFNDLDLSNHPYPRKSPWKVVGNAKLALMTYLYDFQKKAEAHERPDKMPCNLHTIMAN 287
Query: 230 PGLVMNTNLFSYCTRLPFVGIFFWIL 255
PG+V + G+F ++L
Sbjct: 288 PGVVRTPGFRRVVSFGKVWGLFLYLL 313
>Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 318
Score = 50.4 bits (119), Expect = 3e-06
Identities = 32/85 (37%), Positives = 53/85 (61%), Gaps = 7/85 (8%)
Query: 96 IDLTDLNSVEKAA--TKFTVQEDHLDVLINNAGVMAI----PYELTKDNFEIQMQTNYVS 149
+D+TD S ++AA + V+E L L+NNAGV I P+ LT+D+F+ + N +
Sbjct: 81 LDITDPQSFQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPW-LTRDDFQRVLNVNTMG 139
Query: 150 HFLLTMRLLPLIKARKGRVITVSSL 174
+T+ LLPL++ +GRVI ++S+
Sbjct: 140 PIGVTLALLPLLQQARGRVINITSV 164
>CE12990 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 50.4 bits (119), Expect = 3e-06
Identities = 46/220 (20%), Positives = 88/220 (39%), Gaps = 39/220 (17%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
K ++TG +SGIG T + +G +V + GRN+ ++ K++ K
Sbjct: 7 KSVIITGSSSGIGRATAVLFAKNGAQVTITGRNAEKLEATKKKLLK-------------- 52
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELTKDN- 138
+++ + + +LTD ++ + +D+LINNAG + + D
Sbjct: 53 ----VVKTPDSVNVVVANLTDAQGQDQIIQSAVKKFGKIDILINNAGANVVDGTVNTDQS 108
Query: 139 ---FEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQFNYWPSM 195
+ Q N+ + + + + KG ++ VSS+ P
Sbjct: 109 IDLYHKTFQINFQAVVEMVKKTKKYLIESKGEIVNVSSIAAG---------------PQA 153
Query: 196 FFMWCRYALAKTASIQFTKMLAIK--NPDILCMSLHPGLV 233
M YA AK A Q+T+ +A+ + S+ PG++
Sbjct: 154 VSMSPYYAAAKAALNQYTRCVALDLIKQGVRVNSVSPGII 193
>CE09505 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 249
Score = 50.4 bits (119), Expect = 3e-06
Identities = 44/149 (29%), Positives = 65/149 (43%), Gaps = 29/149 (19%)
Query: 20 KVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEKP 79
K L+TG N GIG + H K+ +I + +D
Sbjct: 4 KSLLITGANRGIGLGLLKQFLKH----------------------KDIQIIIATCRDPSK 41
Query: 80 HDGLMIRKTGKLEYLHIDLTDLNSVEK--AATKFTVQEDHLDVLINNAGVMAIPY----E 133
+ L K +L L +D+ S+ K A + V ED L VL+NNAG++ +PY E
Sbjct: 42 AEELSNLKDSRLHILPLDIDCDESISKLYAEVEKLVGEDGLTVLLNNAGIL-LPYDVEGE 100
Query: 134 LTKDNFEIQMQTNYVSHFLLTMRLLPLIK 162
+ Q++TN VS L+T LPL+K
Sbjct: 101 KNRKTLIRQLETNSVSTALITQEFLPLLK 129
>At3g26770 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 50.4 bits (119), Expect = 3e-06
Identities = 49/182 (26%), Positives = 75/182 (40%), Gaps = 36/182 (19%)
Query: 1 MWEEFDITKLPYYDPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAI 60
M+ ITK +Y K++ KVAL+TGG SG+G T HG +V + ++
Sbjct: 1 MYALIQITK--FYSKKLEGKVALITGGASGLGKATASEFLRHGARVVIADLDAETGTKTA 58
Query: 61 KEIKKEAEIRLRKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDV 120
KE+ EA E++ D+T + A + LDV
Sbjct: 59 KELGSEA------------------------EFVRCDVTVEADIAGAVEMTVERYGKLDV 94
Query: 121 LINNAGVM-----AIPYELTKDNFEIQMQTN---YVSHFLLTMRLLPLIKARKGRVITVS 172
+ NNAG++ A +L FE M+ N VS + +I AR G ++ S
Sbjct: 95 MYNNAGIVGPMTPASISQLDMTEFERVMRINVFGVVSGIKHAAKF--MIPARSGCILCTS 152
Query: 173 SL 174
S+
Sbjct: 153 SV 154
>CE14538 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 50.1 bits (118), Expect = 5e-06
Identities = 55/223 (24%), Positives = 99/223 (43%), Gaps = 41/223 (18%)
Query: 19 NKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQDEK 78
++VA+VTG ++GIG T + L G KV + GRN+ R+ + + + K
Sbjct: 7 DEVAIVTGSSNGIGRATAILLASEGAKVTITGRNAERLEESRQALLKVGV---------- 56
Query: 79 PHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAI-PYELTKD 137
+G + + D+T + + +++LINNAG + + P T
Sbjct: 57 --------PSGHINSVVADVTTGAGQDVLIDSTLKKFGKINILINNAGALIVDPEGKTNT 108
Query: 138 NFEIQ-----MQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQFNYW 192
+ ++ Q N+ S +T ++ P + G ++ VSS+G P A+ N +
Sbjct: 109 STGVETCLKTFQLNFQSVVEMTQKIRPHLANTHGEIVNVSSVG-------AGPAAE-NRF 160
Query: 193 PSMFFMWCRYALAKTASIQFTKMLAIK-NPDILCMSL-HPGLV 233
P Y+ AK A Q+++ AI PD + +++ PG V
Sbjct: 161 P-------YYSAAKAALDQYSRNTAIDLIPDGIRVNIVQPGFV 196
>CE03951 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 50.1 bits (118), Expect = 5e-06
Identities = 57/238 (23%), Positives = 97/238 (39%), Gaps = 42/238 (17%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
+ KVA++TG + GIG T L G KV + GR+ R+ + K+ +A I
Sbjct: 4 RFSGKVAIITGSSFGIGRATALLFAKEGAKVTVTGRSEERLQGS-KQALLDAGI------ 56
Query: 76 DEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIPYELT 135
+ D+T + + +K + +++L+NNAG +
Sbjct: 57 -----------SDSNFLIVPADITTSSGQDALISKTLEKFGQINILVNNAGASIADSQNR 105
Query: 136 K------DNFEIQMQTNYVSHFLLTMRLLPLIKARKGRVITVSSLGHNLIFFNCNPGAQF 189
D +E ++ N S +T ++ P + +G ++ VSS+ NP
Sbjct: 106 AGLDQGIDTYEKVLKLNVQSVIEMTQKIRPHLAKTRGEIVNVSSVAALKFAHVRNP---- 161
Query: 190 NYWPSMFFMWCRYALAKTASIQFTKMLAIK--NPDILCMSLHPGLVMNTNLFSYCTRL 245
Y+P LAK A Q+T+ AI + I +++PG+V T CT L
Sbjct: 162 -YYP----------LAKAALDQYTRSAAIDLISQGIRVNTVNPGVVA-TGFHESCTGL 207
>At1g63380 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 287
Score = 50.1 bits (118), Expect = 5e-06
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 24/165 (14%)
Query: 16 KVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRLRKGQ 75
++ +KV LVTG +SGIG L L G K+ R R+N EI I +
Sbjct: 21 ELKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGV---- 76
Query: 76 DEKPHDGLMIRKTGKLEYLHIDL-TDLNSVEKAATKFTVQEDHLDVLINNAGV---MAIP 131
+ L +D+ ++ +++ KA + +DVLINNAG+ +
Sbjct: 77 --------------QAVALELDVSSEADTIRKAVKEAWETFGKIDVLINNAGIRGNVKSS 122
Query: 132 YELTKDNFEIQMQTNYVSHFLLTMRLLPLIK--ARKGRVITVSSL 174
+L+++ ++ +TN +L++ + L++ R G VI VSS+
Sbjct: 123 LDLSEEEWDKVFRTNLTGSWLISKYVCLLMRDAERGGSVINVSSI 167
>Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 313
Score = 49.7 bits (117), Expect = 6e-06
Identities = 34/91 (37%), Positives = 53/91 (57%), Gaps = 5/91 (5%)
Query: 90 KLEYLHIDLTDLNSVEKAA--TKFTVQEDHLDVLINNAGV--MAIPYE-LTKDNFEIQMQ 144
+L+ +D+T S++ AA + V E L L+NNAGV + P E LTKD+F +
Sbjct: 72 RLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVIN 131
Query: 145 TNYVSHFLLTMRLLPLIKARKGRVITVSSLG 175
N V +T+ +LP++K +GRV+ +SS G
Sbjct: 132 VNLVGLIEVTLHMLPMVKRARGRVVNMSSSG 162
>At5g51030 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 314
Score = 49.3 bits (116), Expect = 8e-06
Identities = 46/173 (26%), Positives = 78/173 (44%), Gaps = 33/173 (19%)
Query: 10 LPYYDPK---VDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKE 66
+PY D + VA+VTG N GIG+ V L HG V L R+ + + E
Sbjct: 25 IPYSDHQRWWTSETVAVVTGANRGIGFEMVRQLAGHGLTVILTSRD--------ENVGVE 76
Query: 67 AEIRLRKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAG 126
A L++G +++ +D+ D +S+++ + +DVLINNAG
Sbjct: 77 AAKILQEG-------------GFNVDFHRLDILDSSSIQEFCEWIKEKYGFIDVLINNAG 123
Query: 127 VMAIPYELTKDN----FEIQMQTNYVSHFLLTMRLLPLIK--ARKGRVITVSS 173
V Y + DN + + TNY + ++PL++ + R++ V+S
Sbjct: 124 V---NYNVGSDNSVEFSHMVISTNYYGTKNIINAMIPLMRHACQGARIVNVTS 173
>7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 399
Score = 49.3 bits (116), Expect = 8e-06
Identities = 43/169 (25%), Positives = 77/169 (45%), Gaps = 25/169 (14%)
Query: 12 YYDPKVDNKVALVTGGNSGIGYYTVLHLYLHGFKVYLGGRNSSRVNHAIKEIKKEAEIRL 71
Y + +++ +AL+TGG +G+G L G KV + N + ++ +++
Sbjct: 79 YPEKELNTDIALITGGGNGLGRLLAERLGKMGTKVVIWDINKKGIAETVQIVEEAG---- 134
Query: 72 RKGQDEKPHDGLMIRKTGKLEYLHIDLTDLNSVEKAATKFTVQEDHLDVLINNAGVMAIP 131
G + +D++ V KAA + + +LINNAGV++
Sbjct: 135 -----------------GYCKGYVVDISKKEEVYKAADVIRDEVGDITLLINNAGVVSGL 177
Query: 132 YEL-TKDN-FEIQMQTNYVSHFLLTMRLLP-LIKARKGRVITVSSL-GH 176
+ L T D+ E N ++HF T LP +I+ +G + T++SL GH
Sbjct: 178 HLLDTPDHLIERSFNVNVMAHFWTTKAFLPKMIENDRGHIATIASLAGH 226
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.323 0.139 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,295,678
Number of Sequences: 60738
Number of extensions: 851770
Number of successful extensions: 2504
Number of sequences better than 1.0e-05: 93
Number of HSP's better than 0.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 2342
Number of HSP's gapped (non-prelim): 105
length of query: 330
length of database: 30,389,216
effective HSP length: 107
effective length of query: 223
effective length of database: 23,890,250
effective search space: 5327525750
effective search space used: 5327525750
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)