ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV1597 good OPR KOG2195 General function prediction only Transferrin receptor and related proteins containing the protease-associated (PA) domain
r_klactIV1597 good OPR KOG2195 Inorganic ion transport and metabolism Transferrin receptor and related proteins containing the protease-associated (PA) domain
r_klactIV1597 good OPR KOG2195 Posttranslational modification, protein turnover, chaperones Transferrin receptor and related proteins containing the protease-associated (PA) domain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV1597 551109 549535 -525
(525 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBR286w [OPR] KOG2195 Transferrin receptor and related proteins ... 666 0.0
YDR415c [OPR] KOG2195 Transferrin receptor and related proteins ... 53 1e-06
YBR074w [OR] KOG2194 Aminopeptidases of the M20 family 52 2e-06
YJR126c [OPR] KOG2195 Transferrin receptor and related proteins ... 52 3e-06
>YBR286w [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 563
Score = 666 bits (1719), Expect = 0.0
Identities = 334/518 (64%), Positives = 403/518 (77%), Gaps = 17/518 (3%)
Query: 21 LPQYIQEVFSTGEVSESLQNLSDFFEDGSKSSV---FTWPHLPYFLKPGVDSEKLQDSIT 77
+PQ+ QE F + E ++N D S+V PH+PYF+KP V+SEKLQD I
Sbjct: 50 IPQFFQEAF---QQEEPIENYLPQLNDDDSSAVAANIPKPHIPYFMKPHVESEKLQDKIK 106
Query: 78 IDQLNDTAWDLYHAANASTKQYGHPTRVIGSKGHWKTIGYILSQLDEHKDYYDISVQSFP 137
+D LN TAWDLY AN ST YGHPTRVIGSKGH KT+ YIL+ D+ +DYYD+S+Q F
Sbjct: 107 VDDLNATAWDLYRLANYSTPDYGHPTRVIGSKGHNKTMEYILNVFDDMQDYYDVSLQEFE 166
Query: 138 ALTGKVNSFNLSFVG-GDKVPTATPFALTPPVKGFLGKLIEIPNLGCDDIDYKSLVVPKN 196
AL+GK+ SFNLS G T FAL+PPV GF+GKL+EIPNLGC++ DY S+V P++
Sbjct: 167 ALSGKIISFNLSDAETGKSFANTTAFALSPPVDGFVGKLVEIPNLGCEEKDYASVVPPRH 226
Query: 197 S---IALIERGQCPFGRKSNLAGKHGFKAALIYDNDPLSKDGIKGTLEKPDKHTVATIGV 253
+ IALIERG+CPFG KSNLAGK GF A +IYDN+P SK+G+ GTL +P KHTVAT+GV
Sbjct: 227 NEKQIALIERGKCPFGDKSNLAGKFGFTAVVIYDNEPKSKEGLHGTLGEPTKHTVATVGV 286
Query: 254 SYKEGKKLIAALELHQGDYSLYFEVDSFVKNIKTKNIIADTKHGDPENIVALGAHSDSVS 313
YK GKKLIA + L+ DYSLYF +DS+V+ IKT+NIIADTKHGDP+NIVALGAHSDSV
Sbjct: 287 PYKVGKKLIANIALNI-DYSLYFAMDSYVEFIKTQNIIADTKHGDPDNIVALGAHSDSVE 345
Query: 314 NGPGINDDGSGAISLLTVAKQLTGYKINNKVRFAWWAAEEEGLLGSVFYADHLSPEENSK 373
GPGINDDGSG ISLL VAKQLT +KINNKVRFAWWAAEEEGLLGS FYA +L+ EENSK
Sbjct: 346 EGPGINDDGSGTISLLNVAKQLTHFKINNKVRFAWWAAEEEGLLGSNFYAYNLTKEENSK 405
Query: 374 IRLFMDYDMMASPNYEYQVYDANNKDHPAGSKELKNLYIDYYQSKNLTYSLIPFDGRSDY 433
IR+FMDYDMMASPNYEY++YDANNK++P GS+ELKNLY+DYY++ +L Y+L+PFDGRSDY
Sbjct: 406 IRVFMDYDMMASPNYEYEIYDANNKENPKGSEELKNLYVDYYKAHHLNYTLVPFDGRSDY 465
Query: 434 VGFINHGIPSGGIATGAEGINDENGLPFDKCYHSLCDDVSNLAFDAFLVNTQLIAHSVAT 493
VGFIN+GIP+GGIATGAE N NG D+CYH LCDDVSNL++DAF+ NT+LIAHSVAT
Sbjct: 466 VGFINNGIPAGGIATGAEKNNVNNGKVLDRCYHQLCDDVSNLSWDAFITNTKLIAHSVAT 525
Query: 494 YAKSLEDFPQR------NLNVTSENVADFSYRGSHLIL 525
YA S E FP+R +++ + F YR LI+
Sbjct: 526 YADSFEGFPKRETQKHKEVDILNAQQPQFKYRADFLII 563
>YDR415c [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 374
Score = 53.1 bits (126), Expect = 1e-06
Identities = 35/108 (32%), Positives = 57/108 (52%), Gaps = 18/108 (16%)
Query: 290 IIADTKHGDPENIVALGAHSDSVS-------NGPGINDDGSGAISLLTVAKQLT------ 336
I+ T PE+I+ +G+H DS++ PG +D+GSG ++ + + T
Sbjct: 159 IVRVTGSTTPEDIIIIGSHQDSINLLLPSIMAAPGADDNGSGTVTNMEALRLYTENFLKR 218
Query: 337 GYKINNKVRFAWWAAEEEGLLGS--VFYADHLSPEENSKIRLFMDYDM 382
G++ NN V F +++AEE GLLGS VF A ++ +R + DM
Sbjct: 219 GFRPNNTVEFHFYSAEEGGLLGSLDVFTA---YAKQKKHVRAMLQQDM 263
>YBR074w [OR] KOG2194 Aminopeptidases of the M20 family
Length = 413
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/216 (23%), Positives = 87/216 (39%), Gaps = 22/216 (10%)
Query: 227 DNDPLSKDGIKGTLEKPDKHTVATIGVSYKEGKKLIAALELHQGDYSLYFEVDSFVKNIK 286
+ND + +K LE + A++ + + ++ + + S + V F +
Sbjct: 78 ENDKVHDYLLKRVLEITGNSSFASVSDDKESERSILFQQQDPFNESSRFSRVTYF----E 133
Query: 287 TKNIIADTKHGDPENI-VALGAHSDSVSNGPGINDDGSGAISLLTVAKQLTGYKINNKVR 345
+ NI+ + +PE + L AH DSV G G DDG G +SLL K ++ N +
Sbjct: 134 SSNILVKLEGKNPEEEGLLLSAHFDSVPTGYGATDDGMGVVSLLANLKYHIKHRPNRTLI 193
Query: 346 FAWWAAEEEGLLGSVFYADHL------------SPEENSKIRLFMDYDMMASPNYEYQVY 393
F + EE GLLG+ Y DH K LF D + ++Y
Sbjct: 194 FNFNNNEEFGLLGASTYFDHSWSNLTKYVINLEGTGAGGKAVLFRTSDTSTA-----RIY 248
Query: 394 DANNKDHPAGSKELKNLYIDYYQSKNLTYSLIPFDG 429
+ K++P G+ + + Y Y + +G
Sbjct: 249 QQSVKENPFGNSIYQQGFYSRYVRSETDYKIYEENG 284
>YJR126c [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 811
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/183 (26%), Positives = 83/183 (44%), Gaps = 26/183 (14%)
Query: 300 ENIVALGAHSDSVSNGPGINDDGSGAISLLTVAKQLT-----GYKINNKVRFAWWAAEEE 354
E + +GAH DS+++ D SG+ LL +A+ ++ G+K ++ W E
Sbjct: 437 EGEIIIGAHRDSLASSSA-GDANSGSAILLEIARGMSKLLKHGWKPLRPIKLISWDGERS 495
Query: 355 GLLGSVFYADHLSPEENSKIRLFMDYD---------MMASPNYEYQVYDANNKDHPAGSK 405
GLLGS YA+ + + ++++ D A+P + +Y+A G +
Sbjct: 496 GLLGSTDYAEAHAAILRRRALVYLNLDNAISGTNFHCKANPLLQDVIYEAAKLTEFNGHE 555
Query: 406 ELKNLYIDYYQSKNLTYSLIPFDGRSDYVGFINH-GIPSGGIATGAEGINDENGLPFDKC 464
+ +L+ + + N T SL+ DG S Y F H G+P+ A ND +G
Sbjct: 556 DW-SLFDHWKYTSNATISLL--DGLSSYTSFQYHLGVPAAHFQFNA---NDTSG----AV 605
Query: 465 YHS 467
YHS
Sbjct: 606 YHS 608
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,848,230
Number of Sequences: 60738
Number of extensions: 1511783
Number of successful extensions: 2500
Number of sequences better than 1.0e-05: 4
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2494
Number of HSP's gapped (non-prelim): 4
length of query: 525
length of database: 30,389,216
effective HSP length: 111
effective length of query: 414
effective length of database: 23,647,298
effective search space: 9789981372
effective search space used: 9789981372
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)