ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV1635 good T KOG0789 Signal transduction mechanisms Protein tyrosine phosphatase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV1635 565742 568450 903
(903 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR208w [T] KOG0789 Protein tyrosine phosphatase 399 e-110
YER075c [T] KOG0789 Protein tyrosine phosphatase 105 2e-22
Hs22052020_2 [T] KOG0789 Protein tyrosine phosphatase 103 1e-21
Hs18860900 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 97 1e-19
CE24794 [T] KOG4228 Protein tyrosine phosphatase 92 3e-18
Hs19743925 [T] KOG4228 Protein tyrosine phosphatase 92 5e-18
Hs19743923 [T] KOG4228 Protein tyrosine phosphatase 92 5e-18
Hs19743921 [T] KOG4228 Protein tyrosine phosphatase 92 5e-18
Hs19743919 [T] KOG4228 Protein tyrosine phosphatase 92 5e-18
Hs4506311 [T] KOG4228 Protein tyrosine phosphatase 91 8e-18
Hs18860896 [T] KOG4228 Protein tyrosine phosphatase 91 8e-18
Hs4506309 [T] KOG4228 Protein tyrosine phosphatase 88 7e-17
Hs18860894 [T] KOG4228 Protein tyrosine phosphatase 88 7e-17
Hs18860892 [T] KOG4228 Protein tyrosine phosphatase 88 7e-17
Hs18860890 [T] KOG4228 Protein tyrosine phosphatase 88 7e-17
Hs4885567 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contai... 87 9e-17
SPAC26F1.10c [T] KOG0789 Protein tyrosine phosphatase 86 2e-16
Hs4506323 [T] KOG0791 Protein tyrosine phosphatase contains fn3 ... 86 3e-16
Hs18491010 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 86 3e-16
Hs13677218 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 86 3e-16
Hs13677216 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 86 3e-16
Hs13677214 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 86 3e-16
7292674 [T] KOG0791 Protein tyrosine phosphatase contains fn3 do... 85 4e-16
7294551 [T] KOG4228 Protein tyrosine phosphatase 83 2e-15
7301780 [T] KOG0789 Protein tyrosine phosphatase 82 3e-15
CE06525 [T] KOG0789 Protein tyrosine phosphatase 82 4e-15
Hs18375655 [T] KOG0789 Protein tyrosine phosphatase 82 5e-15
Hs5902032 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contai... 81 6e-15
Hs18104993 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 81 6e-15
Hs18104991 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 81 6e-15
Hs18104989 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 81 6e-15
CE06093 [T] KOG4228 Protein tyrosine phosphatase 81 6e-15
Hs18860898_2 [T] KOG0789 Protein tyrosine phosphatase 81 6e-15
Hs18860904 [T] KOG4228 Protein tyrosine phosphatase 81 8e-15
Hs18104986 [T] KOG0792 Protein tyrosine phosphatase PTPMEG conta... 81 8e-15
YDL230w [T] KOG0789 Protein tyrosine phosphatase 80 1e-14
Hs18375642 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 80 1e-14
Hs15619018 [T] KOG0789 Protein tyrosine phosphatase 80 1e-14
At1g71860 [T] KOG0789 Protein tyrosine phosphatase 80 1e-14
Hs4506329 [T] KOG0789 Protein tyrosine phosphatase 80 2e-14
Hs4506295 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contai... 79 2e-14
CE27280 [T] KOG0789 Protein tyrosine phosphatase 79 2e-14
CE20481 [T] KOG0789 Protein tyrosine phosphatase 79 2e-14
CE09981 [T] KOG0789 Protein tyrosine phosphatase 79 2e-14
Hs7706280 [T] KOG0789 Protein tyrosine phosphatase 79 3e-14
Hs4506289 [T] KOG0789 Protein tyrosine phosphatase 79 3e-14
CE02705 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and r... 79 3e-14
Hs5729993 [T] KOG4228 Protein tyrosine phosphatase 79 4e-14
Hs18860859 [T] KOG4228 Protein tyrosine phosphatase 79 4e-14
Hs18860902 [T] KOG4228 Protein tyrosine phosphatase 78 5e-14
Hs18641364 [T] KOG4228 Protein tyrosine phosphatase 78 7e-14
Hs18641362 [T] KOG4228 Protein tyrosine phosphatase 78 7e-14
Hs18641347 [T] KOG4228 Protein tyrosine phosphatase 78 7e-14
CE29408 [T] KOG4228 Protein tyrosine phosphatase 78 7e-14
CE26369 [T] KOG4228 Protein tyrosine phosphatase 78 7e-14
SPAC11E3.09 [T] KOG0791 Protein tyrosine phosphatase contains fn... 75 5e-13
7291964 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains... 75 6e-13
Hs5453992 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contai... 74 1e-12
Hs19743931 [T] KOG4228 Protein tyrosine phosphatase 74 1e-12
Hs18375650 [T] KOG0792 Protein tyrosine phosphatase PTPMEG conta... 74 1e-12
Hs18375648 [T] KOG0792 Protein tyrosine phosphatase PTPMEG conta... 74 1e-12
Hs18375646 [T] KOG0792 Protein tyrosine phosphatase PTPMEG conta... 74 1e-12
CE15903 [T] KOG0789 Protein tyrosine phosphatase 74 1e-12
CE03335 [T] KOG0791 Protein tyrosine phosphatase contains fn3 do... 74 1e-12
Hs19743935 [T] KOG4228 Protein tyrosine phosphatase 74 1e-12
Hs19743933 [T] KOG4228 Protein tyrosine phosphatase 74 1e-12
CE16864 [T] KOG0789 Protein tyrosine phosphatase 74 1e-12
Hs4506291 [T] KOG0789 Protein tyrosine phosphatase 73 2e-12
Hs18104982 [T] KOG0789 Protein tyrosine phosphatase 73 2e-12
Hs18104980 [T] KOG0789 Protein tyrosine phosphatase 73 2e-12
CE11200 [T] KOG0789 Protein tyrosine phosphatase 73 2e-12
SPAC19D5.01 [T] KOG0789 Protein tyrosine phosphatase 72 3e-12
Hs4506313 [T] KOG0791 Protein tyrosine phosphatase contains fn3 ... 72 3e-12
Hs4506303 [T] KOG4228 Protein tyrosine phosphatase 70 1e-11
Hs18450369 [T] KOG4228 Protein tyrosine phosphatase 70 1e-11
7298436 [T] KOG4228 Protein tyrosine phosphatase 68 7e-11
Hs19743929 [T] KOG4228 Protein tyrosine phosphatase 64 1e-09
Hs19743927 [T] KOG4228 Protein tyrosine phosphatase 64 1e-09
CE20702 [T] KOG0789 Protein tyrosine phosphatase 60 2e-08
CE05815 [T] KOG0789 Protein tyrosine phosphatase 58 6e-08
7290546 [T] KOG0791 Protein tyrosine phosphatase contains fn3 do... 57 1e-07
CE09339 [T] KOG0789 Protein tyrosine phosphatase 57 2e-07
7297098 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains... 52 3e-06
Hs18375644 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 52 4e-06
CE28359 [T] KOG0789 Protein tyrosine phosphatase 52 5e-06
>YOR208w [T] KOG0789 Protein tyrosine phosphatase
Length = 750
Score = 399 bits (1024), Expect = e-110
Identities = 290/816 (35%), Positives = 395/816 (47%), Gaps = 206/816 (25%)
Query: 120 KDFHTLHVSFPSTLLRRPRTTFHQLISTL------HIETQALLKDRLLSSDHIVIYDEHS 173
KD L + PSTL++R F L+ +IE ++KD D + D S
Sbjct: 103 KDITVLSLPLPSTLVKRSNYPFENLLKNYLGSDEKYIEFTKIIKDY----DIFIFSDSFS 158
Query: 174 TLHRCNQQTCSVIMKLIPFLNEQNPSYTIS--LIEGGPSSFNKQRFPP------NVAVPL 225
+ C + T +I K F+ PS + L+EG S N + P N +P
Sbjct: 159 RISSCLKTTFCLIEKFKKFICHFFPSPYLKFFLLEG---SLNDSKAPSLGKNKKNCILPK 215
Query: 226 PSFKISHPEDGKDNNGNSKHPNLKLHIPQVDESQISPNLISSASSTRMFIQSLKRDSIHY 285
++ N + NL+++IP PN S ++F+QSLK+D IHY
Sbjct: 216 LDLNLNV------NLTSRSTLNLRINIPP-------PN-----DSNKIFLQSLKKDLIHY 257
Query: 286 SPNSIKKYFVFHTPEVLPSH---VPRWLSPYNTKNDS--VVERIFEDFETLEALEVRRLE 340
SPNS++K+F F+ P L + +P WL + K + +++++F +FETLE E++RLE
Sbjct: 258 SPNSLQKFFQFNMPADLAPNDTILPNWLKFCSVKENEKVILKKLFNNFETLENFEMQRLE 317
Query: 341 KCLMATXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXIRLPEKQ--SPHTEL 398
KCL +L +KQ T+
Sbjct: 318 KCLKFKKKPLHQK---------------------------------QLSQKQRGPQSTDD 344
Query: 399 GKEYSLRSLQKEYKPNGNLDESDDDTLVMKHSNGSVDEKLRRDIKEELNDSNKHNLIGKL 458
K YSL SLQ++YK + +K + + K LI
Sbjct: 345 SKLYSLTSLQRQYKSS---------------------------LKSNIQKNQKLKLIIPK 377
Query: 459 NTVSPGLLPVLKNDADSGITVVSRSSQYPDASDINASNFNEKMANSDEEVVETPLGNYQM 518
N S SS P +SD + + +P+ +Y++
Sbjct: 378 NNTS--------------------SSPSPLSSD---------------DTIMSPINDYEL 402
Query: 519 TKGIQSFTKNRYSNILPYEHSRVRLQPSPLAEXXXXXXXXXXXXXAPKSGKYDNLTPGGN 578
T+GIQSFTKNRYSNILPYEHSRV+L SP P +
Sbjct: 403 TEGIQSFTKNRYSNILPYEHSRVKLPHSP-------------------------KPPAVS 437
Query: 579 RRRELELQTVDENAGYFSQDSSPTRLYSHPANRSETTATSETDYDTEPFNDYFNANYLRL 638
E +T S P +H + DY NANYL+L
Sbjct: 438 EASTTETKTDK------SYPMCPVDAKNH--------SCKPNDY--------INANYLKL 475
Query: 639 PQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRK 698
QINPDF YIATQAPLPST+DDFW V+ +KVIISLNS DEL+++KWDIYWN+ S
Sbjct: 476 TQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSN 535
Query: 699 HEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE--------SRP 750
H +K+ NT+E++ +I GC+LRV V K+ Q+ N D LP + S P
Sbjct: 536 HTIKLQNTWENICNINGCVLRVFQVKKTAP--QNDNISQDCD-LPHNGDLTSITMAVSEP 592
Query: 751 HTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNN---KTEDFLHTYRKL 807
VYQLQY WLDSCG++M D I ++ +KN LL +P S +L K + +L
Sbjct: 593 FIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLLFNPQSFITSLEKDVCKPDLIDDNNSEL 652
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
L + N SP+LVHCSAGCGRTGVF+TLDFLL +L +N SNKIDVWNM+ DLIFI
Sbjct: 653 HLDTAN----SSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSNKIDVWNMTQDLIFI 708
Query: 868 VVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEHI 903
+VNELRKQRISMVQNLTQY+ CYE++L +F L++ I
Sbjct: 709 IVNELRKQRISMVQNLTQYIACYEALLNYFALQKQI 744
>YER075c [T] KOG0789 Protein tyrosine phosphatase
Length = 928
Score = 105 bits (263), Expect = 2e-22
Identities = 92/329 (27%), Positives = 142/329 (42%), Gaps = 51/329 (15%)
Query: 618 SETDYDTEPFNDYFNANYLRLPQINPDFN--------------YIATQAPLPSTIDDFWN 663
S + D ++Y NANYL LP+ + + N YIATQAP+PST+ DF+
Sbjct: 559 SHSTSDGGILDNYINANYLSLPRFSVEQNSSFQTTTTTTRRVRYIATQAPMPSTVHDFYT 618
Query: 664 VVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKV-----------TNTYEDVFD 712
+L+ + +++SL + E ++K YW + VK+ T+ ++
Sbjct: 619 CILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLLEKKILKMPSTTSMRKNTMG 678
Query: 713 IPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESR-PHTVYQLQYTKWLDSCGINMRD 771
L V + S + N + N S P T D I +R
Sbjct: 679 TQNSSLYSAGVQGNSSNYSTDNDNDNDNNNNNNNNSNIPVTAAACDDDDDDDDDAILIRQ 738
Query: 772 FIHIYH------------IKN-----LLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNK 814
+ YH +KN LLN P S+ A+N K H L + +
Sbjct: 739 ILLTYHDQEKPYELLQIQVKNWPDLGTLLN-PISILQAINVKN----HIIDTLFARNYYQ 793
Query: 815 NNSGSPVLVHCSAGCGRTGVFITLDFLLG---VLDSRSNQSNKIDVWNMSADLIFIVVNE 871
N+ +LVHCSAGCGRTG T+D +L + + + K+ D I +N
Sbjct: 794 NDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQKEFVKLKYPAKLFDPISWTINI 853
Query: 872 LRKQRISMVQNLTQYLTCYESMLEFFYLK 900
RK+RISMVQN+ Q++ Y+ +L +F L+
Sbjct: 854 FRKERISMVQNINQFIFIYDCLLFYFRLR 882
Score = 59.3 bits (142), Expect = 3e-08
Identities = 66/226 (29%), Positives = 97/226 (42%), Gaps = 33/226 (14%)
Query: 98 ITDLKPDDSTFLLDLTSHGYPLKDFHT--LHVSFPSTLLRRPRTTFHQLISTLHIETQAL 155
I + PD+ LLD+ K T +HV PSTLLRR TF +L+ L Q++
Sbjct: 106 IIETLPDEKVLLLDVRPFTEHAKSIITNSIHVCLPSTLLRRKNFTFSKLLDNLTPSEQSV 165
Query: 156 LKDRL-LSSDHIVIYDE--HSTLHRCNQQTCSVIMKLIPFLNEQNPSYTISLIEGGPSSF 212
LK +L + + I+IYD + T + + KLI F + N T+S++ G F
Sbjct: 166 LKSKLAIDNLRIIIYDSTANQTESSVSLPCYGIASKLIEF--DTNVKKTVSILMCGFPQF 223
Query: 213 NKQRFPPNV---AVPLPSFKISHPEDGKDNNGNSKH----------------PNLKLHIP 253
K FP ++ + P+ K N NS H NLKL +P
Sbjct: 224 -KILFPDHINTNTFNSDCISSAEPKSPKTNLMNSLHNTAPHMTATTPLSSPQMNLKLKVP 282
Query: 254 QVDESQISPNLISSASSTRMFIQSLKRDSIHYSPNSIKKYFVFHTP 299
D+S+ + SS+ S R ++ DS S + I F F P
Sbjct: 283 --DDSRSDHSNFSSSPSPR----NVLSDSPMSSSSPISALFKFQLP 322
>Hs22052020_2 [T] KOG0789 Protein tyrosine phosphatase
Length = 307
Score = 103 bits (257), Expect = 1e-21
Identities = 87/296 (29%), Positives = 128/296 (42%), Gaps = 69/296 (23%)
Query: 606 SHPANRSETTATSETDYDTEPF-----NDYFNANYLRLPQINPDFNYIATQAPLPSTIDD 660
+ P+NR + YD+ DY NA+Y+R+ ++ YIATQ PL STIDD
Sbjct: 66 NQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDD 125
Query: 661 FWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDI-PGCILR 719
FW +VL N VI + E + K YW + E+K + + + I I+R
Sbjct: 126 FWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIR 185
Query: 720 VMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIK 779
+ V + K+ H+V QLQ+TKW D
Sbjct: 186 MFQVVE-------------------KSTGTSHSVKQLQFTKWPDH--------------- 211
Query: 780 NLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLD 839
PAS + F+ R K++ P++VHCSAG GRTGVF+ +D
Sbjct: 212 ----GTPAS--------ADSFIKYIR-----YARKSHLTGPMVVHCSAGIGRTGVFLCVD 254
Query: 840 FLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
+ + V N S +++ IV ++R+QR MVQ QY CY+ +LE
Sbjct: 255 VVFCAI-----------VKNCSFNIMDIVA-QMREQRSGMVQTKEQYHFCYDIVLE 298
>Hs18860900 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1337
Score = 97.1 bits (240), Expect = 1e-19
Identities = 92/331 (27%), Positives = 135/331 (39%), Gaps = 87/331 (26%)
Query: 586 QTVDENAGYFSQD--------SSPTRLYSHPANRSETTATSETDYD---------TEPFN 628
Q D N G+ + S P NR + + YD T +
Sbjct: 1033 QQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTD 1092
Query: 629 DYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWD 688
DY NANY+ P + ++IATQ PLP+T+ DFW +V KN+ II L E K +
Sbjct: 1093 DYINANYM--PGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCE 1150
Query: 689 IYWNSKSIRKH-EVKVTNTYEDVFDIPGCILR---VMNVSKSDSRIQSPNKRTKFDQLPV 744
YW SK + + ++ V T E V +P +R V N+ S+S
Sbjct: 1151 EYWPSKQAQDYGDITVAMTSEIV--LPEWTIRDFTVKNIQTSES---------------- 1192
Query: 745 KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTY 804
H + Q +T W D G+ T D L +
Sbjct: 1193 ------HPLRQFHFTSWPDH-GV---------------------------PDTTDLLINF 1218
Query: 805 RKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADL 864
R L + ++ SP+LVHCSAG GRTG FI +D L+ +++ N +DV+
Sbjct: 1219 RYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIEN----ENTVDVYG----- 1269
Query: 865 IFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
+V +LR R MVQ QY+ + +L+
Sbjct: 1270 ---IVYDLRMHRPLMVQTEDQYVFLNQCVLD 1297
>CE24794 [T] KOG4228 Protein tyrosine phosphatase
Length = 2234
Score = 92.4 bits (228), Expect = 3e-18
Identities = 97/409 (23%), Positives = 156/409 (37%), Gaps = 78/409 (19%)
Query: 500 KMANSDEEVVETPLGNYQMTKGIQSFTKNRYSNILPYEHSR--------VRLQPSPLAEX 551
K+ ++ E + Y+ G + LP HSR V + P
Sbjct: 1592 KLLSTSNEYGRQIMNPYEQMNGNHHMESSMDLYPLPTSHSRSNGYAPVPVAIPSLPNNGN 1651
Query: 552 XXXXXXXXXXXXAPKSGKYDNLTPGGNRRRELELQTVDENAGYFSQDSSPTRLYSHPANR 611
A + + L N + E +++ E +F+ + S + H
Sbjct: 1652 NMTTVSHPAVPIAELANHIERLRMNNNAGFQSEFESI-ETGQHFTWEHSSADMNKHKNRY 1710
Query: 612 SETTATSET-----DYDTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVL 666
+ A + + + P DY NANY+ + +YIATQ PLP T DFW +V
Sbjct: 1711 ANVAAYDHSRVVLSNVEGYPGMDYINANYV--DGYDKPRSYIATQGPLPETFSDFWRMVW 1768
Query: 667 SKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKS 726
+ I+ L + +E K D YW S+ T TY DI +L ++++
Sbjct: 1769 EEQSVTIVMLTNLEERSRVKCDQYWPSRG--------TATYG---DIEVTLLESVHLAHY 1817
Query: 727 DSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDP 786
R +L + E + LQYT W D
Sbjct: 1818 TMRTM---------RLKMVGEPEVREIKHLQYTAWPD----------------------- 1845
Query: 787 ASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLD 846
+ + + FL +++ L N N++G P++ HCSAG GRTG FI +D +L
Sbjct: 1846 ----HGVPDHPTPFLIFLKRVKTL--NPNDAG-PIISHCSAGIGRTGAFIVIDCML---- 1894
Query: 847 SRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
R N +D++ V LR QR MVQ QY+ ++++L+
Sbjct: 1895 ERLRYDNTVDIYG--------CVTALRAQRSYMVQTEEQYIFIHDAVLD 1935
>Hs19743925 [T] KOG4228 Protein tyrosine phosphatase
Length = 1505
Score = 91.7 bits (226), Expect = 5e-18
Identities = 77/279 (27%), Positives = 117/279 (41%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA+++ YIATQ PL T +DFW ++ N +++ L E+ +K
Sbjct: 1290 SDYINASFI--DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKC 1347
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1348 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1387
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ TV Q Q+T W + G DFI H KT++
Sbjct: 1388 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH------------------KTKE---- 1425
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1426 ----------QFGQDGPISVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1464
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
IF V LR QR +MVQ +Y CY++ LE+ +H
Sbjct: 1465 -IFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDH 1502
Score = 80.9 bits (198), Expect = 8e-15
Identities = 72/268 (26%), Positives = 107/268 (39%), Gaps = 64/268 (23%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NANY+ YIATQ PLP T DFW +V + I+ + +E K
Sbjct: 1001 SDYINANYV--DGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKC 1058
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
D YW ++ + + T D ++ +R ++ K+ S
Sbjct: 1059 DQYWPNRGTETYGF-IQVTLLDTIELATFCVRTFSLHKNGS------------------- 1098
Query: 748 SRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKL 807
S V Q Q+T W D + + FL R+
Sbjct: 1099 SEKREVRQFQFTAWPD---------------------------HGVPEYPTPFLAFLRR- 1130
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
+ + N ++G P++VHCSAG GRTG FI +D +L R +DV+
Sbjct: 1131 -VKTCNPPDAG-PIVVHCSAGVGRTGCFIVIDAML----ERIKPEKTVDVYGH------- 1177
Query: 868 VVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY +E++LE
Sbjct: 1178 -VTLMRSQRNYMVQTEDQYSFIHEALLE 1204
>Hs19743923 [T] KOG4228 Protein tyrosine phosphatase
Length = 1910
Score = 91.7 bits (226), Expect = 5e-18
Identities = 77/279 (27%), Positives = 117/279 (41%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA+++ YIATQ PL T +DFW ++ N +++ L E+ +K
Sbjct: 1695 SDYINASFI--DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKC 1752
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1753 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1792
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ TV Q Q+T W + G DFI H KT++
Sbjct: 1793 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH------------------KTKE---- 1830
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1831 ----------QFGQDGPISVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1869
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
IF V LR QR +MVQ +Y CY++ LE+ +H
Sbjct: 1870 -IFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDH 1907
Score = 80.9 bits (198), Expect = 8e-15
Identities = 72/268 (26%), Positives = 107/268 (39%), Gaps = 64/268 (23%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NANY+ YIATQ PLP T DFW +V + I+ + +E K
Sbjct: 1406 SDYINANYV--DGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKC 1463
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
D YW ++ + + T D ++ +R ++ K+ S
Sbjct: 1464 DQYWPNRGTETYGF-IQVTLLDTIELATFCVRTFSLHKNGS------------------- 1503
Query: 748 SRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKL 807
S V Q Q+T W D + + FL R+
Sbjct: 1504 SEKREVRQFQFTAWPD---------------------------HGVPEYPTPFLAFLRR- 1535
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
+ + N ++G P++VHCSAG GRTG FI +D +L R +DV+
Sbjct: 1536 -VKTCNPPDAG-PIVVHCSAGVGRTGCFIVIDAML----ERIKPEKTVDVYGH------- 1582
Query: 868 VVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY +E++LE
Sbjct: 1583 -VTLMRSQRNYMVQTEDQYSFIHEALLE 1609
>Hs19743921 [T] KOG4228 Protein tyrosine phosphatase
Length = 1501
Score = 91.7 bits (226), Expect = 5e-18
Identities = 77/279 (27%), Positives = 117/279 (41%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA+++ YIATQ PL T +DFW ++ N +++ L E+ +K
Sbjct: 1286 SDYINASFI--DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKC 1343
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1344 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1383
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ TV Q Q+T W + G DFI H KT++
Sbjct: 1384 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH------------------KTKE---- 1421
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1422 ----------QFGQDGPISVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1460
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
IF V LR QR +MVQ +Y CY++ LE+ +H
Sbjct: 1461 -IFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDH 1498
Score = 80.9 bits (198), Expect = 8e-15
Identities = 72/268 (26%), Positives = 107/268 (39%), Gaps = 64/268 (23%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NANY+ YIATQ PLP T DFW +V + I+ + +E K
Sbjct: 997 SDYINANYV--DGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKC 1054
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
D YW ++ + + T D ++ +R ++ K+ S
Sbjct: 1055 DQYWPNRGTETYGF-IQVTLLDTIELATFCVRTFSLHKNGS------------------- 1094
Query: 748 SRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKL 807
S V Q Q+T W D + + FL R+
Sbjct: 1095 SEKREVRQFQFTAWPD---------------------------HGVPEYPTPFLAFLRR- 1126
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
+ + N ++G P++VHCSAG GRTG FI +D +L R +DV+
Sbjct: 1127 -VKTCNPPDAG-PIVVHCSAGVGRTGCFIVIDAML----ERIKPEKTVDVYGH------- 1173
Query: 868 VVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY +E++LE
Sbjct: 1174 -VTLMRSQRNYMVQTEDQYSFIHEALLE 1200
>Hs19743919 [T] KOG4228 Protein tyrosine phosphatase
Length = 1948
Score = 91.7 bits (226), Expect = 5e-18
Identities = 77/279 (27%), Positives = 117/279 (41%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA+++ YIATQ PL T +DFW ++ N +++ L E+ +K
Sbjct: 1733 SDYINASFI--DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKC 1790
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1791 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1830
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ TV Q Q+T W + G DFI H KT++
Sbjct: 1831 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH------------------KTKE---- 1868
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1869 ----------QFGQDGPISVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1907
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
IF V LR QR +MVQ +Y CY++ LE+ +H
Sbjct: 1908 -IFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDH 1945
Score = 80.9 bits (198), Expect = 8e-15
Identities = 72/268 (26%), Positives = 107/268 (39%), Gaps = 64/268 (23%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NANY+ YIATQ PLP T DFW +V + I+ + +E K
Sbjct: 1444 SDYINANYV--DGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKC 1501
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
D YW ++ + + T D ++ +R ++ K+ S
Sbjct: 1502 DQYWPNRGTETYGF-IQVTLLDTIELATFCVRTFSLHKNGS------------------- 1541
Query: 748 SRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKL 807
S V Q Q+T W D + + FL R+
Sbjct: 1542 SEKREVRQFQFTAWPD---------------------------HGVPEYPTPFLAFLRR- 1573
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
+ + N ++G P++VHCSAG GRTG FI +D +L R +DV+
Sbjct: 1574 -VKTCNPPDAG-PIVVHCSAGVGRTGCFIVIDAML----ERIKPEKTVDVYGH------- 1620
Query: 868 VVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY +E++LE
Sbjct: 1621 -VTLMRSQRNYMVQTEDQYSFIHEALLE 1647
>Hs4506311 [T] KOG4228 Protein tyrosine phosphatase
Length = 1897
Score = 90.9 bits (224), Expect = 8e-18
Identities = 77/279 (27%), Positives = 116/279 (40%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA++L YIATQ PL + +DFW ++ N +I+ L E+ +K
Sbjct: 1682 SDYINASFL--DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKC 1739
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1740 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1779
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ T+ Q Q+T W + G DFI H KT++
Sbjct: 1780 GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVH------------------KTKE---- 1817
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1818 ----------QFGQDGPITVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1856
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
+F V LR QR +MVQ QY CY + LE+ +H
Sbjct: 1857 -MFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDH 1894
Score = 79.0 bits (193), Expect = 3e-14
Identities = 71/276 (25%), Positives = 109/276 (38%), Gaps = 64/276 (23%)
Query: 620 TDYDTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSY 679
T D P +DY NANY+ YIATQ PLP T+ DFW +V + ++ +
Sbjct: 1385 TSIDGVPGSDYINANYI--DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRL 1442
Query: 680 DELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKF 739
+E K D YW ++ + + T D ++ +R + KS S
Sbjct: 1443 EEKSRVKCDQYWPARGTETCGL-IQVTLLDTVELATYTVRTFALHKSGS----------- 1490
Query: 740 DQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTED 799
S + Q Q+ W D + +
Sbjct: 1491 --------SEKRELRQFQFMAWPD---------------------------HGVPEYPTP 1515
Query: 800 FLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWN 859
L R+ + + N ++G P++VHCSAG GRTG FI +D +L R +D++
Sbjct: 1516 ILAFLRR--VKACNPLDAG-PMVVHCSAGVGRTGCFIVIDAML----ERMKHEKTVDIYG 1568
Query: 860 MSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY+ +E++LE
Sbjct: 1569 H--------VTCMRSQRNYMVQTEDQYVFIHEALLE 1596
>Hs18860896 [T] KOG4228 Protein tyrosine phosphatase
Length = 1888
Score = 90.9 bits (224), Expect = 8e-18
Identities = 77/279 (27%), Positives = 116/279 (40%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA++L YIATQ PL + +DFW ++ N +I+ L E+ +K
Sbjct: 1673 SDYINASFL--DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKC 1730
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1731 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1770
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ T+ Q Q+T W + G DFI H KT++
Sbjct: 1771 GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVH------------------KTKE---- 1808
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1809 ----------QFGQDGPITVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1847
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
+F V LR QR +MVQ QY CY + LE+ +H
Sbjct: 1848 -MFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDH 1885
Score = 79.0 bits (193), Expect = 3e-14
Identities = 71/276 (25%), Positives = 109/276 (38%), Gaps = 64/276 (23%)
Query: 620 TDYDTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSY 679
T D P +DY NANY+ YIATQ PLP T+ DFW +V + ++ +
Sbjct: 1376 TSIDGVPGSDYINANYI--DGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRL 1433
Query: 680 DELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKF 739
+E K D YW ++ + + T D ++ +R + KS S
Sbjct: 1434 EEKSRVKCDQYWPARGTETCGL-IQVTLLDTVELATYTVRTFALHKSGS----------- 1481
Query: 740 DQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTED 799
S + Q Q+ W D + +
Sbjct: 1482 --------SEKRELRQFQFMAWPD---------------------------HGVPEYPTP 1506
Query: 800 FLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWN 859
L R+ + + N ++G P++VHCSAG GRTG FI +D +L R +D++
Sbjct: 1507 ILAFLRR--VKACNPLDAG-PMVVHCSAGVGRTGCFIVIDAML----ERMKHEKTVDIYG 1559
Query: 860 MSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY+ +E++LE
Sbjct: 1560 H--------VTCMRSQRNYMVQTEDQYVFIHEALLE 1587
>Hs4506309 [T] KOG4228 Protein tyrosine phosphatase
Length = 1912
Score = 87.8 bits (216), Expect = 7e-17
Identities = 77/279 (27%), Positives = 115/279 (40%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA+++ YIATQ PL T +DFW ++ N +++ L E+ +K
Sbjct: 1697 SDYINASFI--DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKC 1754
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1755 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1794
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ TV Q Q+T W + G DFI H KT++
Sbjct: 1795 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH------------------KTKE---- 1832
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1833 ----------QFGQDGPISVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1871
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
IF V LR QR +MVQ QY Y + LE+ +H
Sbjct: 1872 -IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH 1909
Score = 82.0 bits (201), Expect = 4e-15
Identities = 71/270 (26%), Positives = 108/270 (39%), Gaps = 64/270 (23%)
Query: 626 PFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMK 685
P +DY NANY+ YIATQ LP T DFW ++ + ++ + +E
Sbjct: 1406 PGSDYVNANYI--DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRV 1463
Query: 686 KWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVK 745
K D YW S+ H + V T D ++ +R + K+ S
Sbjct: 1464 KCDQYWPSRGTETHGL-VQVTLLDTVELATYCVRTFALYKNGS----------------- 1505
Query: 746 NESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYR 805
S V Q Q+T W D + + FL R
Sbjct: 1506 --SEKREVRQFQFTAWPD---------------------------HGVPEHPTPFLAFLR 1536
Query: 806 KLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLI 865
+ + + N ++G P++VHCSAG GRTG FI +D +L R +D++
Sbjct: 1537 R--VKTCNPPDAG-PMVVHCSAGVGRTGCFIVIDAML----ERIKHEKTVDIYGH----- 1584
Query: 866 FIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY+ ++++LE
Sbjct: 1585 ---VTLMRAQRNYMVQTEDQYIFIHDALLE 1611
>Hs18860894 [T] KOG4228 Protein tyrosine phosphatase
Length = 1501
Score = 87.8 bits (216), Expect = 7e-17
Identities = 77/279 (27%), Positives = 115/279 (40%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA+++ YIATQ PL T +DFW ++ N +++ L E+ +K
Sbjct: 1286 SDYINASFI--DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKC 1343
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1344 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1383
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ TV Q Q+T W + G DFI H KT++
Sbjct: 1384 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH------------------KTKE---- 1421
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1422 ----------QFGQDGPISVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1460
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
IF V LR QR +MVQ QY Y + LE+ +H
Sbjct: 1461 -IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH 1498
Score = 82.0 bits (201), Expect = 4e-15
Identities = 71/270 (26%), Positives = 108/270 (39%), Gaps = 64/270 (23%)
Query: 626 PFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMK 685
P +DY NANY+ YIATQ LP T DFW ++ + ++ + +E
Sbjct: 995 PGSDYVNANYI--DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRV 1052
Query: 686 KWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVK 745
K D YW S+ H + V T D ++ +R + K+ S
Sbjct: 1053 KCDQYWPSRGTETHGL-VQVTLLDTVELATYCVRTFALYKNGS----------------- 1094
Query: 746 NESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYR 805
S V Q Q+T W D + + FL R
Sbjct: 1095 --SEKREVRQFQFTAWPD---------------------------HGVPEHPTPFLAFLR 1125
Query: 806 KLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLI 865
+ + + N ++G P++VHCSAG GRTG FI +D +L R +D++
Sbjct: 1126 R--VKTCNPPDAG-PMVVHCSAGVGRTGCFIVIDAML----ERIKHEKTVDIYGH----- 1173
Query: 866 FIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY+ ++++LE
Sbjct: 1174 ---VTLMRAQRNYMVQTEDQYIFIHDALLE 1200
>Hs18860892 [T] KOG4228 Protein tyrosine phosphatase
Length = 1903
Score = 87.8 bits (216), Expect = 7e-17
Identities = 77/279 (27%), Positives = 115/279 (40%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA+++ YIATQ PL T +DFW ++ N +++ L E+ +K
Sbjct: 1688 SDYINASFI--DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKC 1745
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1746 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1785
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ TV Q Q+T W + G DFI H KT++
Sbjct: 1786 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH------------------KTKE---- 1823
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1824 ----------QFGQDGPISVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1862
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
IF V LR QR +MVQ QY Y + LE+ +H
Sbjct: 1863 -IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH 1900
Score = 82.0 bits (201), Expect = 4e-15
Identities = 71/270 (26%), Positives = 108/270 (39%), Gaps = 64/270 (23%)
Query: 626 PFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMK 685
P +DY NANY+ YIATQ LP T DFW ++ + ++ + +E
Sbjct: 1397 PGSDYVNANYI--DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRV 1454
Query: 686 KWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVK 745
K D YW S+ H + V T D ++ +R + K+ S
Sbjct: 1455 KCDQYWPSRGTETHGL-VQVTLLDTVELATYCVRTFALYKNGS----------------- 1496
Query: 746 NESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYR 805
S V Q Q+T W D + + FL R
Sbjct: 1497 --SEKREVRQFQFTAWPD---------------------------HGVPEHPTPFLAFLR 1527
Query: 806 KLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLI 865
+ + + N ++G P++VHCSAG GRTG FI +D +L R +D++
Sbjct: 1528 R--VKTCNPPDAG-PMVVHCSAGVGRTGCFIVIDAML----ERIKHEKTVDIYGH----- 1575
Query: 866 FIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY+ ++++LE
Sbjct: 1576 ---VTLMRAQRNYMVQTEDQYIFIHDALLE 1602
>Hs18860890 [T] KOG4228 Protein tyrosine phosphatase
Length = 1899
Score = 87.8 bits (216), Expect = 7e-17
Identities = 77/279 (27%), Positives = 115/279 (40%), Gaps = 70/279 (25%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA+++ YIATQ PL T +DFW ++ N +++ L E+ +K
Sbjct: 1684 SDYINASFI--DGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKC 1741
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++ +++ V + + +++P ILR V+ D+R +
Sbjct: 1742 HQYWPAERSARYQYFVVDPMAE-YNMPQYILREFKVT--DAR-----------------D 1781
Query: 748 SRPHTVYQLQYTKW----LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ TV Q Q+T W + G DFI H KT++
Sbjct: 1782 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVH------------------KTKE---- 1819
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ P+ VHCSAG GRTGVFITL +L R +D
Sbjct: 1820 ----------QFGQDGPISVHCSAGVGRTGVFITLSIVL----ERMRYEGVVD------- 1858
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEH 902
IF V LR QR +MVQ QY Y + LE+ +H
Sbjct: 1859 -IFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDH 1896
Score = 82.0 bits (201), Expect = 4e-15
Identities = 71/270 (26%), Positives = 108/270 (39%), Gaps = 64/270 (23%)
Query: 626 PFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMK 685
P +DY NANY+ YIATQ LP T DFW ++ + ++ + +E
Sbjct: 1393 PGSDYVNANYI--DGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRV 1450
Query: 686 KWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVK 745
K D YW S+ H + V T D ++ +R + K+ S
Sbjct: 1451 KCDQYWPSRGTETHGL-VQVTLLDTVELATYCVRTFALYKNGS----------------- 1492
Query: 746 NESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYR 805
S V Q Q+T W D + + FL R
Sbjct: 1493 --SEKREVRQFQFTAWPD---------------------------HGVPEHPTPFLAFLR 1523
Query: 806 KLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLI 865
+ + + N ++G P++VHCSAG GRTG FI +D +L R +D++
Sbjct: 1524 R--VKTCNPPDAG-PMVVHCSAGVGRTGCFIVIDAML----ERIKHEKTVDIYGH----- 1571
Query: 866 FIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R QR MVQ QY+ ++++LE
Sbjct: 1572 ---VTLMRAQRNYMVQTEDQYIFIHDALLE 1598
>Hs4885567 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 1187
Score = 87.4 bits (215), Expect = 9e-17
Identities = 78/290 (26%), Positives = 126/290 (42%), Gaps = 60/290 (20%)
Query: 610 NRSETTATSETDYDTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKN 669
NR E T E + Y NA+++++ +++YIATQ PLP T DFW +V +
Sbjct: 948 NRVELIPTKENN------TGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQG 1001
Query: 670 LKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSR 729
+ VI + + +E K YW K KH + TY +V ++DS
Sbjct: 1002 VNVIAMVTAEEEGGRTKSHRYW-PKLGSKHS---SATYGK--------FKVTTKFRTDSV 1049
Query: 730 IQSPNKRTKFDQLPVKN--ESRPHTVYQLQYTKWLD-SCGINMRDFIHIYHIKNLLLNDP 786
+ L VK+ + TV+ LQYT W D C +++ F+
Sbjct: 1050 CYATT------GLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFL------------- 1090
Query: 787 ASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLD 846
+ E+ R + N P++VHCSAG GRTGV I + ++ L+
Sbjct: 1091 --------SYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLE 1142
Query: 847 SRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
+ K++V M + LR+QR+ M+Q + QY Y+ +++F
Sbjct: 1143 ----HNEKVEVPMM--------LRLLREQRMFMIQTIAQYKFVYQVLIQF 1180
>SPAC26F1.10c [T] KOG0789 Protein tyrosine phosphatase
Length = 550
Score = 86.3 bits (212), Expect = 2e-16
Identities = 83/315 (26%), Positives = 135/315 (42%), Gaps = 65/315 (20%)
Query: 581 RELELQTVDENAGYFSQDSSPTRLYSHPANRSETTATSETDYDTEPFNDYFNANYLRLPQ 640
R + TVD + + + T + + R TS ++ D Y NA++++
Sbjct: 281 RNSQWSTVDSLSNTSYKKNRYTDIVPYNCTRVHLKRTSPSELD------YINASFIK--- 331
Query: 641 INPDFNYIATQAPLPSTIDDFWNVVLS--KNLKVIISLNSYDELDMKKWDIYWNSKSIRK 698
NYIA Q + +I DFW++V +N+ I+ L S E + YW S I
Sbjct: 332 -TETSNYIACQGSISRSISDFWHMVWDNVENIGTIVMLGSLFEAGREMCTAYWPSNGIGD 390
Query: 699 HEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHT--VYQL 756
+V Y D C+ ++ + +SR KF+ ++N + P V+
Sbjct: 391 KQV-----YGDY-----CVKQISEENVDNSRFIL----RKFE---IQNANFPSVKKVHHY 433
Query: 757 QYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNN 816
QY W D N P ++ + + +FL VN ++
Sbjct: 434 QYPNWSDC-------------------NSPENVKSMV-----EFLKY--------VNNSH 461
Query: 817 SGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQR 876
+VHCSAG GRTG FI LD +L +S+ + N S+D++F +V+ +RKQR
Sbjct: 462 GSGNTIVHCSAGVGRTGTFIVLDTILRFPESKLSGFNPSVA--DSSDVVFQLVDHIRKQR 519
Query: 877 ISMVQNLTQYLTCYE 891
+ MVQ TQ+ Y+
Sbjct: 520 MKMVQTFTQFKYVYD 534
>Hs4506323 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1188
Score = 85.9 bits (211), Expect = 3e-16
Identities = 83/296 (28%), Positives = 118/296 (39%), Gaps = 77/296 (26%)
Query: 608 PANRSETTATSETDYD----------TEPFNDYFNANYLRLPQINPDFNYIATQAPLPST 657
P NR + T+ YD E DY NANY+ P N YIATQ PLP T
Sbjct: 932 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYI--PGYNSPQEYIATQGPLPET 989
Query: 658 IDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYW--NSKSIRKHEVKVTNTYEDVFDIPG 715
+DFW +VL + ++I+ L +E K D YW + I ++ V E+ D
Sbjct: 990 RNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWA 1049
Query: 716 CILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHI 775
C R ++ +D V YT W D G+
Sbjct: 1050 C--RHFRINYADEM---------------------QDVMHFNYTAWPDH-GV-------- 1077
Query: 776 YHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVF 835
P + NA + + F+H R+ S P+++HCSAG GRTG F
Sbjct: 1078 ----------PTA--NAAESILQ-FVHMVRQ------QATKSKGPMIIHCSAGVGRTGTF 1118
Query: 836 ITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYE 891
I LD LL +D+ + V+E+R R+SMVQ QY+ ++
Sbjct: 1119 IALDRLL----QHIRDHEFVDILGL--------VSEMRSYRMSMVQTEEQYIFIHQ 1162
>Hs18491010 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1997
Score = 85.9 bits (211), Expect = 3e-16
Identities = 76/279 (27%), Positives = 117/279 (41%), Gaps = 60/279 (21%)
Query: 613 ETTATSETDYDTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKV 672
+ T ++ D +P +DY NA+Y+ P N YI TQ PLP T DDFW +V +N+
Sbjct: 1740 DATRVKLSNVDDDPCSDYINASYI--PGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHN 1797
Query: 673 IISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQS 732
I+ + E K D YW + +D IL++++ S
Sbjct: 1798 IVMVTQCVEKGRVKCDHYWPAD-------------QDSLYYGDLILQMLSESVLPEWTIR 1844
Query: 733 PNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNA 792
K +QL + YT W D G+ P + +
Sbjct: 1845 EFKICGEEQLDAH-----RLIRHFHYTVWPDH-GV------------------PETTQSL 1880
Query: 793 LNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQS 852
+ F+ T R +N++ P +VHCSAG GRTG FI LD +L LDS+
Sbjct: 1881 I-----QFVRTVRDY----INRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLDSK---- 1927
Query: 853 NKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYE 891
+ +D++ V++LR R+ MVQ QY+ ++
Sbjct: 1928 DSVDIYG--------AVHDLRLHRVHMVQTECQYVYLHQ 1958
>Hs13677218 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 405
Score = 85.9 bits (211), Expect = 3e-16
Identities = 83/296 (28%), Positives = 118/296 (39%), Gaps = 77/296 (26%)
Query: 608 PANRSETTATSETDYD----------TEPFNDYFNANYLRLPQINPDFNYIATQAPLPST 657
P NR + T+ YD E DY NANY+ P N YIATQ PLP T
Sbjct: 149 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYI--PGYNSPQEYIATQGPLPET 206
Query: 658 IDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYW--NSKSIRKHEVKVTNTYEDVFDIPG 715
+DFW +VL + ++I+ L +E K D YW + I ++ V E+ D
Sbjct: 207 RNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWA 266
Query: 716 CILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHI 775
C R ++ +D V YT W D G+
Sbjct: 267 C--RHFRINYADEM---------------------QDVMHFNYTAWPDH-GV-------- 294
Query: 776 YHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVF 835
P + NA + + F+H R+ S P+++HCSAG GRTG F
Sbjct: 295 ----------PTA--NAAESILQ-FVHMVRQ------QATKSKGPMIIHCSAGVGRTGTF 335
Query: 836 ITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYE 891
I LD LL +D+ + V+E+R R+SMVQ QY+ ++
Sbjct: 336 IALDRLL----QHIRDHEFVDILGL--------VSEMRSYRMSMVQTEEQYIFIHQ 379
>Hs13677216 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 377
Score = 85.9 bits (211), Expect = 3e-16
Identities = 83/296 (28%), Positives = 118/296 (39%), Gaps = 77/296 (26%)
Query: 608 PANRSETTATSETDYD----------TEPFNDYFNANYLRLPQINPDFNYIATQAPLPST 657
P NR + T+ YD E DY NANY+ P N YIATQ PLP T
Sbjct: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYI--PGYNSPQEYIATQGPLPET 178
Query: 658 IDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYW--NSKSIRKHEVKVTNTYEDVFDIPG 715
+DFW +VL + ++I+ L +E K D YW + I ++ V E+ D
Sbjct: 179 RNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWA 238
Query: 716 CILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHI 775
C R ++ +D V YT W D G+
Sbjct: 239 C--RHFRINYADEM---------------------QDVMHFNYTAWPDH-GV-------- 266
Query: 776 YHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVF 835
P + NA + + F+H R+ S P+++HCSAG GRTG F
Sbjct: 267 ----------PTA--NAAESILQ-FVHMVRQ------QATKSKGPMIIHCSAGVGRTGTF 307
Query: 836 ITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYE 891
I LD LL +D+ + V+E+R R+SMVQ QY+ ++
Sbjct: 308 IALDRLL----QHIRDHEFVDILGL--------VSEMRSYRMSMVQTEEQYIFIHQ 351
>Hs13677214 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1216
Score = 85.9 bits (211), Expect = 3e-16
Identities = 83/296 (28%), Positives = 118/296 (39%), Gaps = 77/296 (26%)
Query: 608 PANRSETTATSETDYD----------TEPFNDYFNANYLRLPQINPDFNYIATQAPLPST 657
P NR + T+ YD E DY NANY+ P N YIATQ PLP T
Sbjct: 960 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYI--PGYNSPQEYIATQGPLPET 1017
Query: 658 IDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYW--NSKSIRKHEVKVTNTYEDVFDIPG 715
+DFW +VL + ++I+ L +E K D YW + I ++ V E+ D
Sbjct: 1018 RNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWA 1077
Query: 716 CILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHI 775
C R ++ +D V YT W D G+
Sbjct: 1078 C--RHFRINYADEM---------------------QDVMHFNYTAWPDH-GV-------- 1105
Query: 776 YHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVF 835
P + NA + + F+H R+ S P+++HCSAG GRTG F
Sbjct: 1106 ----------PTA--NAAESILQ-FVHMVRQ------QATKSKGPMIIHCSAGVGRTGTF 1146
Query: 836 ITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYE 891
I LD LL +D+ + V+E+R R+SMVQ QY+ ++
Sbjct: 1147 IALDRLL----QHIRDHEFVDILGL--------VSEMRSYRMSMVQTEEQYIFIHQ 1190
>7292674 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1647
Score = 85.1 bits (209), Expect = 4e-16
Identities = 84/307 (27%), Positives = 128/307 (41%), Gaps = 77/307 (25%)
Query: 608 PANRSETTATSETDYDTEPF----------NDYFNANYLRLPQINPDFNYIATQAPLPST 657
P NR + T+ YD F +DY NANY+ P N +I TQ PL ST
Sbjct: 1310 PCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYV--PGHNSPREFIVTQGPLHST 1367
Query: 658 IDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCI 717
DDFW + N + I+ L E +K D YW + + V Y D+
Sbjct: 1368 RDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDT-------VPVFYGDIK------ 1414
Query: 718 LRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYH 777
++++N S + + + + S + +T W D G+
Sbjct: 1415 VQILNDSHYADWVMT--------EFMLCRGSEQRILRHFHFTTWPDF-GVP--------- 1456
Query: 778 IKNLLLNDPASLFNALNNKTEDFLHTYR-KLGLLSVNKNNSGSPVLVHCSAGCGRTGVFI 836
N P +L F+ +R ++G P++VHCSAG GR+G FI
Sbjct: 1457 ------NPPQTLVR--------FVRAFRDRIGA-------EQRPIVVHCSAGVGRSGTFI 1495
Query: 837 TLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
TLD +L + N S+ +D IF +V +RK+R+ MVQ QY+ ++ +L
Sbjct: 1496 TLDRIL----QQINTSDYVD--------IFGIVYAMRKERVWMVQTEQQYICIHQCLLAV 1543
Query: 897 FYLKEHI 903
KE+I
Sbjct: 1544 LEGKENI 1550
>7294551 [T] KOG4228 Protein tyrosine phosphatase
Length = 1428
Score = 83.2 bits (204), Expect = 2e-15
Identities = 70/268 (26%), Positives = 114/268 (42%), Gaps = 59/268 (22%)
Query: 629 DYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWD 688
DY NAN++ + F I Q P+ STIDDFW ++ ++L++I+ L + +E + K
Sbjct: 912 DYINANFVIGYKERKKF--ICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCA 969
Query: 689 IYWNSKSI-RKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW K K + + I R +NVSK+ + + R +
Sbjct: 970 KYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQ--------- 1020
Query: 748 SRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKL 807
+ Q Y W +DF+ H ++ +N+
Sbjct: 1021 -----ITQYHYLTW--------KDFMAPEHPHGII-----KFIRQINS------------ 1050
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
+ S+ + P+LVHCSAG GRTG + LD L+ L+ + S I+
Sbjct: 1051 -VYSLQRG----PILVHCSAGVGRTGTLVALDSLIQQLEEEDSVS------------IYN 1093
Query: 868 VVNELRKQRISMVQNLTQYLTCYESMLE 895
V +LR QR +VQ+L QY+ Y ++L+
Sbjct: 1094 TVCDLRHQRNFLVQSLKQYIFLYRALLD 1121
>7301780 [T] KOG0789 Protein tyrosine phosphatase
Length = 1285
Score = 82.4 bits (202), Expect = 3e-15
Identities = 75/312 (24%), Positives = 125/312 (40%), Gaps = 75/312 (24%)
Query: 598 DSSPTRLYSHPANRSETTATSETDYDTEPFN-----------DYFNANYLRLPQINPDFN 646
D P HP N+ + + T YD + DY NAN++ Q F
Sbjct: 478 DDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAF- 536
Query: 647 YIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNT 706
I TQ PLP T D FW ++ + + +I+ + + E +K D+YW + + V
Sbjct: 537 -IGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKL 595
Query: 707 YEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHT---VYQLQYTKWLD 763
E+ ++ V + + L +K + + +T VYQ YT W D
Sbjct: 596 IEEE------VMSTYTV-----------RTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPD 638
Query: 764 SCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLV 823
+ + P + N + + + N +G P++V
Sbjct: 639 ----------------HGTPDHPLPVLNFVKKSS-------------AANPAEAG-PIVV 668
Query: 824 HCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNL 883
HCSAG GRTG +I LD +L + Q N ++V F + +R QR +VQ
Sbjct: 669 HCSAGVGRTGTYIVLDAML----KQIQQKNIVNV--------FGFLRHIRAQRNFLVQTE 716
Query: 884 TQYLTCYESMLE 895
QY+ +++++E
Sbjct: 717 EQYIFLHDALVE 728
>CE06525 [T] KOG0789 Protein tyrosine phosphatase
Length = 490
Score = 82.0 bits (201), Expect = 4e-15
Identities = 77/275 (28%), Positives = 122/275 (44%), Gaps = 65/275 (23%)
Query: 623 DTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDEL 682
+ +P NDY +A+++ +P F +I+TQ P+ +TI DFW++V ++ VI+ L Y E
Sbjct: 105 ERDPSNDYIHASWMVMPD---GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEE 161
Query: 683 DMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQL 742
D +K Y++ S ++ Y D RV V K+ + +P K T Q+
Sbjct: 162 DQEKCQRYFSDTSEKE--------YGD--------YRVKVVEKT-VELWNPVKVTGI-QV 203
Query: 743 PVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLH 802
KN H VY Y W D + DPA +
Sbjct: 204 QKKNCPTKHMVYHYFYYDWHD----------------QVAPLDPAPMI------------ 235
Query: 803 TYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSA 862
K+ +NK++S P++VHCSAG GRT F+ + +L ++ N S
Sbjct: 236 ---KMYKAVLNKSSS-KPIVVHCSAGVGRTSTFVGI-YLSQIMIRE----------NSSV 280
Query: 863 DLIFIVVNELRKQRISMVQNLTQYLTCYESMLEFF 897
D++ I + LR R+ VQ+ QY+ M+E F
Sbjct: 281 DMVEI-LKRLRTMRLGAVQSQLQYVYLVVLMIELF 314
>Hs18375655 [T] KOG0789 Protein tyrosine phosphatase
Length = 460
Score = 81.6 bits (200), Expect = 5e-15
Identities = 78/274 (28%), Positives = 118/274 (42%), Gaps = 63/274 (22%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
E +DY N N++R ++ YIATQ PLP T+ DFW +V +KVI+ E
Sbjct: 81 EGHSDYINGNFIR--GVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGR 138
Query: 685 KKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPV 744
K+ + YW ++ E T + CI + + N+ L V
Sbjct: 139 KRCERYW----AQEQEPLQTGLF--------CITLIKE--------KWLNEDIMLRTLKV 178
Query: 745 KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTY 804
+ +VYQLQY W D G+ P+S + L E
Sbjct: 179 TFQKESRSVYQLQYMSWPDR-GV------------------PSSPDHMLAMVEEA----- 214
Query: 805 RKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADL 864
R+L + + P+ VHCSAGCGRTGV T+D++ +L ++ + D
Sbjct: 215 RRL------QGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQM----------IPPDF 258
Query: 865 -IFIVVNELRKQRISMVQNLTQYLTCYESMLEFF 897
+F VV ++RKQR + VQ QY Y ++ + F
Sbjct: 259 SLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF 292
>Hs5902032 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 1174
Score = 81.3 bits (199), Expect = 6e-15
Identities = 70/269 (26%), Positives = 122/269 (45%), Gaps = 53/269 (19%)
Query: 630 YFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDI 689
Y NA+++++ +++YIATQ PL +T DFW +V + + +I + + +E +K
Sbjct: 950 YINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFR 1009
Query: 690 YWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESR 749
YW R + V TY ++ ++DS + K L E
Sbjct: 1010 YWPRLGSRHNTV----TYGR--------FKITTRFRTDSGCYATTG-LKMKHLLTGQE-- 1054
Query: 750 PHTVYQLQYTKWLD-SCGINMRDFI-HIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKL 807
TV+ LQYT W + C +++ F+ ++ I+++ + N T D
Sbjct: 1055 -RTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRH---------TNSTSD-------- 1096
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
+ P+LVHCSAG GRTGV I + ++ L+ + +D+
Sbjct: 1097 ------PQSPNPPLLVHCSAGVGRTGVVILSEIMIACLE----HNEVLDIPR-------- 1138
Query: 868 VVNELRKQRISMVQNLTQYLTCYESMLEF 896
V++ LR+QR+ +VQ L QY Y +++F
Sbjct: 1139 VLDMLRQQRMMLVQTLCQYTFVYRVLIQF 1167
>Hs18104993 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 624
Score = 81.3 bits (199), Expect = 6e-15
Identities = 72/276 (26%), Positives = 109/276 (39%), Gaps = 62/276 (22%)
Query: 626 PFNDYFNANYLRLPQINPDFN---YIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDEL 682
P +DY NANY++ + PD N YIA+Q L +T++DFW + +N +VI+ E
Sbjct: 297 PGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEK 356
Query: 683 DMKKWDIYWNSKSIRKH--EVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFD 740
K YW +++ VTN E D LR + VS
Sbjct: 357 GRNKCVPYWPEVGMQRAYGPYSVTNCGEH--DTTEYKLRTLQVS---------------- 398
Query: 741 QLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDF 800
P+ N ++ QY W D G+ S + +N + E
Sbjct: 399 --PLDNGDLIREIWHYQYLSWPDH-GVPSEP------------GGVLSFLDQINQRQESL 443
Query: 801 LHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNM 860
H P++VHCSAG GRTG I +D L+ + ++ + ID+
Sbjct: 444 PHA---------------GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCD-IDIQK- 486
Query: 861 SADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
+ +R QR MVQ QY Y ++ +F
Sbjct: 487 -------TIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
>Hs18104991 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 597
Score = 81.3 bits (199), Expect = 6e-15
Identities = 72/276 (26%), Positives = 109/276 (39%), Gaps = 62/276 (22%)
Query: 626 PFNDYFNANYLRLPQINPDFN---YIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDEL 682
P +DY NANY++ + PD N YIA+Q L +T++DFW + +N +VI+ E
Sbjct: 299 PGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEK 358
Query: 683 DMKKWDIYWNSKSIRKH--EVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFD 740
K YW +++ VTN E D LR + VS
Sbjct: 359 GRNKCVPYWPEVGMQRAYGPYSVTNCGEH--DTTEYKLRTLQVS---------------- 400
Query: 741 QLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDF 800
P+ N ++ QY W D G+ S + +N + E
Sbjct: 401 --PLDNGDLIREIWHYQYLSWPDH-GVPSEP------------GGVLSFLDQINQRQESL 445
Query: 801 LHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNM 860
H P++VHCSAG GRTG I +D L+ + ++ + ID+
Sbjct: 446 PHA---------------GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCD-IDIQK- 488
Query: 861 SADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
+ +R QR MVQ QY Y ++ +F
Sbjct: 489 -------TIQMVRAQRSGMVQTEAQYKFIYVAIAQF 517
>Hs18104989 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 595
Score = 81.3 bits (199), Expect = 6e-15
Identities = 72/276 (26%), Positives = 109/276 (39%), Gaps = 62/276 (22%)
Query: 626 PFNDYFNANYLRLPQINPDFN---YIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDEL 682
P +DY NANY++ + PD N YIA+Q L +T++DFW + +N +VI+ E
Sbjct: 297 PGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEK 356
Query: 683 DMKKWDIYWNSKSIRKH--EVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFD 740
K YW +++ VTN E D LR + VS
Sbjct: 357 GRNKCVPYWPEVGMQRAYGPYSVTNCGEH--DTTEYKLRTLQVS---------------- 398
Query: 741 QLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDF 800
P+ N ++ QY W D G+ S + +N + E
Sbjct: 399 --PLDNGDLIREIWHYQYLSWPDH-GVPSEP------------GGVLSFLDQINQRQESL 443
Query: 801 LHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNM 860
H P++VHCSAG GRTG I +D L+ + ++ + ID+
Sbjct: 444 PHA---------------GPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCD-IDIQK- 486
Query: 861 SADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
+ +R QR MVQ QY Y ++ +F
Sbjct: 487 -------TIQMVRAQRSGMVQTEAQYKFIYVAIAQF 515
>CE06093 [T] KOG4228 Protein tyrosine phosphatase
Length = 1156
Score = 81.3 bits (199), Expect = 6e-15
Identities = 73/266 (27%), Positives = 114/266 (42%), Gaps = 62/266 (23%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
NDY NANY+ N YIATQAPLPST DFW+++ + +I+ + + E +K
Sbjct: 712 NDYINANYV--DSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKC 769
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
D YW S+ D P S+S + R ++
Sbjct: 770 DQYWPSQQ----------------DSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVP 813
Query: 748 SRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKL 807
+ V+QL + W D G+ P+S+F L+ F+H +
Sbjct: 814 AVERKVHQLHFMGWPDH-GV------------------PSSVFPLLS-----FVHYTSDI 849
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
+S PV+VHCSAG GR+G +I +D + L S +++V
Sbjct: 850 --------HSTGPVVVHCSAGVGRSGSYILVDSMRRHLIS----FRRLNVQGH------- 890
Query: 868 VVNELRKQRISMVQNLTQYLTCYESM 893
+ +R+QR +VQ L QY+ C+E++
Sbjct: 891 -LTHMRRQRAKLVQTLEQYIFCHEAI 915
>Hs18860898_2 [T] KOG0789 Protein tyrosine phosphatase
Length = 745
Score = 81.3 bits (199), Expect = 6e-15
Identities = 78/311 (25%), Positives = 119/311 (38%), Gaps = 71/311 (22%)
Query: 606 SHPANRSETTATSETDYD------------TEPFNDYFNANYLRLPQINPDFNYIATQAP 653
+HP N+ + + YD +DY NANY+ N YIATQ P
Sbjct: 170 NHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYV--DGYNKAKAYIATQGP 227
Query: 654 LPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYW---NSKSIRKHEVKVTNTYEDV 710
L ST +DFW ++ +N +I+ + + E +K D YW NS+ V + +T
Sbjct: 228 LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKST---- 283
Query: 711 FDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMR 770
I C V S +++++ K K V Q YT+W D
Sbjct: 284 -KIHAC-YTVRRFSIRNTKVKKGQKGNP------KGRQNERVVIQYHYTQWPDM------ 329
Query: 771 DFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCG 830
E L + S + PVLVHCSAG G
Sbjct: 330 ------------------------GVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVG 365
Query: 831 RTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCY 890
RTG +I +D +L + +S + + + +R QR +VQ QY+ +
Sbjct: 366 RTGTYIVIDSMLQQIKDKSTVN------------VLGFLKHIRTQRNYLVQTEEQYIFIH 413
Query: 891 ESMLEFFYLKE 901
+++LE KE
Sbjct: 414 DALLEAILGKE 424
>Hs18860904 [T] KOG4228 Protein tyrosine phosphatase
Length = 1452
Score = 80.9 bits (198), Expect = 8e-15
Identities = 78/317 (24%), Positives = 127/317 (39%), Gaps = 75/317 (23%)
Query: 589 DENAGYFSQDSSPTRLYSHPANRSETTATSETDYDT----------EPFNDYFNANYLRL 638
+E +F S+P NR + + YD + +DY N NY+
Sbjct: 902 EEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYI-- 959
Query: 639 PQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRK 698
+ +YIATQ P+ TI DFW +V +N II + + E+ K YW +
Sbjct: 960 DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIY 1019
Query: 699 HEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQY 758
++KVT ++ + ++R V K + + Q +
Sbjct: 1020 KDIKVTLIETEL--LAEYVIRTFAVEK-------------------RGVHEIREIRQFHF 1058
Query: 759 TKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSG 818
T W D G+ YH LL + +K+ S
Sbjct: 1059 TGWPDH-GVP-------YHATGLL-----GFVRQVKSKSPP-----------------SA 1088
Query: 819 SPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRIS 878
P++VHCSAG GRTG FI +D +L + + + +D++N V ELR +R++
Sbjct: 1089 GPLVVHCSAGAGRTGCFIVIDIMLDM----AEREGVVDIYN--------CVRELRSRRVN 1136
Query: 879 MVQNLTQYLTCYESMLE 895
MVQ QY+ ++++LE
Sbjct: 1137 MVQTEEQYVFIHDAILE 1153
>Hs18104986 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM
domain
Length = 913
Score = 80.9 bits (198), Expect = 8e-15
Identities = 79/297 (26%), Positives = 114/297 (37%), Gaps = 69/297 (23%)
Query: 608 PANRSETTATSETDYDT-----EPFNDYFNANY--LRLPQINPDFNYIATQAPLPSTIDD 660
P N + YDT + DY NA+Y + +P N YIATQ PLP T
Sbjct: 668 PQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ 727
Query: 661 FWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRV 720
FW VV + L +I+ L + E K YW DV + G ++
Sbjct: 728 FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP-------------PDVMNHGGFHIQC 774
Query: 721 MNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKN 780
+ D I ++ E HTV LQY W D
Sbjct: 775 QS---EDCTIAYVSREMLVTNTQTGEE---HTVTHLQYVAWPD----------------- 811
Query: 781 LLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDF 840
+ + + + DFL + L V+ P+LVHCSAG GRTGV +T++
Sbjct: 812 ----------HGVPDDSSDFLEFVNYVRSLRVD----SEPLLVHCSAGIGRTGVLVTMET 857
Query: 841 LLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEFF 897
+ L R+ +D +V ++R QR MVQ +QY E++L +
Sbjct: 858 AM-CLTERNLPIYPLD-----------IVRKMRDQRAMMVQTSSQYKFVCEAILRVY 902
>YDL230w [T] KOG0789 Protein tyrosine phosphatase
Length = 335
Score = 80.5 bits (197), Expect = 1e-14
Identities = 86/289 (29%), Positives = 126/289 (42%), Gaps = 65/289 (22%)
Query: 628 NDYFNANYLRL----PQINPDFNYIATQAPLPSTIDDFWNVVLSK----NLKVIISLNSY 679
NDY NA+Y+++ I P + YIATQ P T D FW + N+ VI+ +
Sbjct: 77 NDYINASYVKVNVPGQSIEPGY-YIATQGPTRKTWDQFWQMCYHNCPLDNI-VIVMVTPL 134
Query: 680 DELDMKKWDIYWNSKSIRKHEVKVTNTYE------DVFDIPGCI-LRVMNVSK-SDSRIQ 731
E + +K YW + V++ + +E D+ P + + +NV K D
Sbjct: 135 VEYNREKCYQYWPRGGV-DDTVRIASKWESPGGANDMTQFPSDLKIEFVNVHKVKDYYTV 193
Query: 732 SPNKRTKFDQL--PVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASL 789
+ K T D L PVK TV+ + W D
Sbjct: 194 TDIKLTPTDPLVGPVK------TVHHFYFDLWKDM------------------------- 222
Query: 790 FNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLL-GVLD-- 846
NK E+ + +L S + N+ G+P++VHCSAG GRTG FI LD L+ LD
Sbjct: 223 -----NKPEEVV-PIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFK 276
Query: 847 ---SRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYES 892
RS S++ + DLI +V +LR QR+ MVQ Q+L Y +
Sbjct: 277 NITERSRHSDRA-TEEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHA 324
>Hs18375642 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 593
Score = 80.5 bits (197), Expect = 1e-14
Identities = 74/279 (26%), Positives = 115/279 (40%), Gaps = 63/279 (22%)
Query: 625 EPFNDYFNANYLRLPQIN-------PDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLN 677
EP +DY NAN + +P+ P +YIATQ L +T++DFW +V +N +VI+
Sbjct: 299 EPVSDYINANII-MPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTT 357
Query: 678 SYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRT 737
E K YW + K ++RV NV +S + +
Sbjct: 358 KEVERGKSKCVKYWPDEYALKEY---------------GVMRVRNVKESAAH-DYTLREL 401
Query: 738 KFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKT 797
K ++ N R TV+Q + W D + + +DP + + L
Sbjct: 402 KLSKVGQGNTER--TVWQYHFRTWPD----------------HGVPSDPGGVLDFL---- 439
Query: 798 EDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDV 857
E+ H + PV+VHCSAG GRTG FI +D L+ ++ + + IDV
Sbjct: 440 EEVHHKQESI--------MDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCD-IDV 490
Query: 858 WNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
+ +R QR MVQ QY Y ++ +
Sbjct: 491 PK--------TIQMVRSQRSGMVQTEAQYRFIYMAVQHY 521
>Hs15619018 [T] KOG0789 Protein tyrosine phosphatase
Length = 691
Score = 80.5 bits (197), Expect = 1e-14
Identities = 71/270 (26%), Positives = 110/270 (40%), Gaps = 61/270 (22%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+ Y NAN+++ + YIATQ PL +T+ DFW ++ ++ +I+ E+ KK
Sbjct: 82 SSYINANFIK--GVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKC 139
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
+ YW + E P + KSD I++ L VK
Sbjct: 140 ERYWAEPGEMQLEFG-----------PFSVSCEAEKRKSDYIIRT---------LKVKFN 179
Query: 748 SRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKL 807
S T+YQ Y W D +D S + + D
Sbjct: 180 SETRTIYQFHYKNWPD--------------------HDVPSSIDPILELIWD-------- 211
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
+ + + P+ +HCSAGCGRTGV +D+ +L + I N S +F
Sbjct: 212 --VRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLL------KDGIIPENFS---VFS 260
Query: 868 VVNELRKQRISMVQNLTQYLTCYESMLEFF 897
++ E+R QR S+VQ QY Y ++LE F
Sbjct: 261 LIREMRTQRPSLVQTQEQYELVYNAVLELF 290
>At1g71860 [T] KOG0789 Protein tyrosine phosphatase
Length = 340
Score = 80.5 bits (197), Expect = 1e-14
Identities = 66/269 (24%), Positives = 113/269 (41%), Gaps = 63/269 (23%)
Query: 630 YFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSY--DELDMKKW 687
Y NA+ ++ + +IATQ PLP T++DFW +V+ ++ +I+ L + +K
Sbjct: 117 YVNASLIKTSESESISQFIATQGPLPHTMEDFWEMVIQQHCPIIVMLTRLVDNNRTVKCG 176
Query: 688 DIYWNSKSIRKH-EVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKN 746
D + + R+ + +T + + +D+ + N + +
Sbjct: 177 DYFQDEDGPREFGNISLTTKW---------------IKTTDTSLMLRNLEVNYKE----T 217
Query: 747 ESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRK 806
E +P +V +QY +W D G+ +D + + I L P SL
Sbjct: 218 EDQPMSVLHIQYPEWPDH-GVP-KDTVAVREILKRLYQVPPSL----------------- 258
Query: 807 LGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIF 866
P++VHCSAG GRTG + + N +I +MSA +
Sbjct: 259 ------------GPIIVHCSAGIGRTGTYCAIH----------NTIQRILAGDMSALDLA 296
Query: 867 IVVNELRKQRISMVQNLTQYLTCYESMLE 895
V RKQRI MVQ + QY CY ++++
Sbjct: 297 KTVALFRKQRIGMVQTMDQYFFCYNAIVD 325
>Hs4506329 [T] KOG0789 Protein tyrosine phosphatase
Length = 2314
Score = 79.7 bits (195), Expect = 2e-14
Identities = 75/309 (24%), Positives = 118/309 (37%), Gaps = 70/309 (22%)
Query: 606 SHPANRSETTATSETDYDTE------------PFNDYFNANYLRLPQINPDFNYIATQAP 653
+HP N+ + + YD DY NANY+ N YIA Q P
Sbjct: 1745 NHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYV--DGYNRPKAYIAAQGP 1802
Query: 654 LPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKH-EVKVTNTYEDVFD 712
L ST +DFW ++ N++VI+ + + E +K D YW + ++ VT V
Sbjct: 1803 LKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVL- 1861
Query: 713 IPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDF 772
V N + +++I+ ++ K V Q YT+W D
Sbjct: 1862 ---AYYTVRNFTLRNTKIKKGSQ---------KGRPSGRVVTQYHYTQWPDM-------- 1901
Query: 773 IHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRT 832
E L + + K ++ PV+VHCSAG GRT
Sbjct: 1902 ----------------------GVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRT 1939
Query: 833 GVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYES 892
G +I LD +L + + IF + +R QR +VQ QY+ +++
Sbjct: 1940 GTYIVLDSMLQQIQHEGTVN------------IFGFLKHIRSQRNYLVQTEEQYVFIHDT 1987
Query: 893 MLEFFYLKE 901
++E KE
Sbjct: 1988 LVEAILSKE 1996
>Hs4506295 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM
domain
Length = 926
Score = 79.3 bits (194), Expect = 2e-14
Identities = 76/274 (27%), Positives = 117/274 (41%), Gaps = 69/274 (25%)
Query: 629 DYFNANYLRL--PQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKK 686
DY NANY+ + P + YIA Q PLP T DFW + + +++ L + E K
Sbjct: 703 DYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVK 762
Query: 687 WDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKN 746
YW E +++Y GC +V S+ + K T F+Q KN
Sbjct: 763 CHQYW-------PEPTGSSSY-------GC-YQVTCHSEEGNTAYIFRKMTLFNQ--EKN 805
Query: 747 ESRPHTVYQLQYTKWLDSCGI--NMRDFI-HIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
ESRP T Q+QY W D G+ + DF+ + H++N
Sbjct: 806 ESRPLT--QIQYIAWPDH-GVPDDSSDFLDFVCHVRN----------------------- 839
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+ PV+VHCSAG GRTGV IT++ + +++ V+ +
Sbjct: 840 ---------KRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQ------PVYPLD-- 882
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFF 897
+V +R QR M+Q +QY E++L+ +
Sbjct: 883 ----IVRTMRDQRAMMIQTPSQYRFVCEAILKVY 912
>CE27280 [T] KOG0789 Protein tyrosine phosphatase
Length = 352
Score = 79.3 bits (194), Expect = 2e-14
Identities = 77/276 (27%), Positives = 108/276 (38%), Gaps = 62/276 (22%)
Query: 623 DTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDEL 682
D + DY +ANY++ + F I TQ PL TI DFW ++ + + I+ L E
Sbjct: 108 DKSRYEDYIHANYVKTNYLRNTF--ICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEE 165
Query: 683 DMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKF--D 740
K YW S + VT TY GCI RV N+ +S + N F D
Sbjct: 166 GRPKCVGYWPS-------LGVTETY-------GCI-RVTNMGESSDEFEICNLAVTFVPD 210
Query: 741 QLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDF 800
+PV + ++ KW N D ++
Sbjct: 211 NVPVDEQPANLKELRVNLIKW-----PNWPD----------------------RGVPDEK 243
Query: 801 LHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNM 860
HT + L V P +VHCSAG GRTG + L+F LD + K+D
Sbjct: 244 CHTVPQRLLAQVRH----GPCVVHCSAGIGRTGCVVALEFAYNKLD----RGLKVDFEE- 294
Query: 861 SADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
++ ELRKQR +Q QYL + M+ F
Sbjct: 295 -------IITELRKQRAQCIQTEIQYLYIHRVMIAF 323
>CE20481 [T] KOG0789 Protein tyrosine phosphatase
Length = 398
Score = 79.3 bits (194), Expect = 2e-14
Identities = 82/305 (26%), Positives = 120/305 (38%), Gaps = 73/305 (23%)
Query: 609 ANRSETTATSETDYDTEPFND-------------YFNANYLRLPQINPDFNYIATQAPLP 655
AN+S A ++ Y P D Y +ANY+ P I P+ +I Q PL
Sbjct: 124 ANQSPDIAITKNRYQDVPCQDQSAVKLDQPSPCNYIHANYVGCPMI-PEKRFICAQGPLD 182
Query: 656 STIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPG 715
TID+FW +V+ ++ I+ L E+ K YW + K +K G
Sbjct: 183 QTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLK-----------SG 231
Query: 716 CILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHI 775
C+ V NVS S + P + L + +V LQ+T+W D G+
Sbjct: 232 CV--VENVSGSKPMERDPEIQITMLNLTYSG-GQTMSVRHLQWTEWPDR-GV-------- 279
Query: 776 YHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVF 835
P L L LLS + S P++VHCSAG GRTG
Sbjct: 280 ---------PPCKL---------------TSLELLSAIR-GSKVPIVVHCSAGIGRTGTI 314
Query: 836 ITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
+ ++++L + N + +V LR QR +QN QYL + ML
Sbjct: 315 VAIEYILEKIAE-----------NKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN 363
Query: 896 FFYLK 900
+F K
Sbjct: 364 YFLEK 368
>CE09981 [T] KOG0789 Protein tyrosine phosphatase
Length = 398
Score = 79.3 bits (194), Expect = 2e-14
Identities = 82/305 (26%), Positives = 120/305 (38%), Gaps = 73/305 (23%)
Query: 609 ANRSETTATSETDYDTEPFND-------------YFNANYLRLPQINPDFNYIATQAPLP 655
AN+S A ++ Y P D Y +ANY+ P I P+ +I Q PL
Sbjct: 124 ANQSPDIAITKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCPMI-PEKRFICAQGPLD 182
Query: 656 STIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPG 715
TID+FW +V+ ++ I+ L E+ K YW + K +K G
Sbjct: 183 QTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLK-----------SG 231
Query: 716 CILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHI 775
C+ V NVS S + P + L + +V LQ+T+W D G+
Sbjct: 232 CV--VENVSGSKPMERDPEIQITMLNLTYSG-GQTMSVRHLQWTEWPDR-GV-------- 279
Query: 776 YHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVF 835
P L L LLS + S P++VHCSAG GRTG
Sbjct: 280 ---------PPCKL---------------TSLELLSAIR-GSKVPIVVHCSAGIGRTGTI 314
Query: 836 ITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
+ ++++L + N + +V LR QR +QN QYL + ML
Sbjct: 315 VAIEYILEKIAE-----------NKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN 363
Query: 896 FFYLK 900
+F K
Sbjct: 364 YFLEK 368
>Hs7706280 [T] KOG0789 Protein tyrosine phosphatase
Length = 807
Score = 79.0 bits (193), Expect = 3e-14
Identities = 78/318 (24%), Positives = 124/318 (38%), Gaps = 71/318 (22%)
Query: 590 ENAGYFSQDSSPTRLYSHPANRSETTATSETDYD----------TEPFNDYFNANYLRLP 639
++ Y + + PT + P N + YD ++ + Y NAN+++
Sbjct: 34 QSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIK-- 91
Query: 640 QINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKH 699
+ YIATQ PL +T+ DFW ++ ++ +I E+ KK + YW +
Sbjct: 92 GVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIGMACMEYEMGKKKCERYWAEPVEMQL 151
Query: 700 EVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYT 759
E P + KSD I++ L VK S T+YQ Y
Sbjct: 152 EFG-----------PFSVSCEAEKRKSDYIIRT---------LKVKFNSETRTIYQFHYK 191
Query: 760 KWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGS 819
W D +D S + + D + + +
Sbjct: 192 NWPD--------------------HDVPSSIDPILELIWD----------VRCYQEDDSV 221
Query: 820 PVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISM 879
P+ +HCSAGCGRTGV +D+ +L + I N S +F ++ E+R QR S+
Sbjct: 222 PICIHCSAGCGRTGVICAIDYTWMLL------KDGIIPENFS---VFSLIREMRTQRPSL 272
Query: 880 VQNLTQYLTCYESMLEFF 897
VQ QY Y ++LE F
Sbjct: 273 VQTQEQYELVYNAVLELF 290
>Hs4506289 [T] KOG0789 Protein tyrosine phosphatase
Length = 435
Score = 79.0 bits (193), Expect = 3e-14
Identities = 78/303 (25%), Positives = 125/303 (40%), Gaps = 65/303 (21%)
Query: 601 PTRLYSHPANRSETTATSETDYDTEPF------NDYFNANYLRLPQINPDFNYIATQAPL 654
P R+ P N++ + +D NDY NA+ +++ + +YI TQ PL
Sbjct: 31 PCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQR--SYILTQGPL 88
Query: 655 PSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIP 714
P+T FW +V + + ++ LN E K YW K ++ + TN
Sbjct: 89 PNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTN--------- 139
Query: 715 GCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHT--VYQLQYTKWLDSCGINMRDF 772
L++ +S+ + QL ++N + T + YT W D G+
Sbjct: 140 ---LKLTLISEDIKSYYTVR------QLELENLTTQETREILHFHYTTWPD-FGVP---- 185
Query: 773 IHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRT 832
PAS N FL R+ G LS PV+VHCSAG GR+
Sbjct: 186 -----------ESPASFLN--------FLFKVRESGSLSPEH----GPVVVHCSAGIGRS 222
Query: 833 GVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYES 892
G F D L ++D R + S+ +D+ V+ E+RK R+ ++Q Q Y +
Sbjct: 223 GTFCLADTCLLLMDKRKDPSS-VDIKK--------VLLEMRKFRMGLIQTADQLRFSYLA 273
Query: 893 MLE 895
++E
Sbjct: 274 VIE 276
>CE02705 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 668
Score = 79.0 bits (193), Expect = 3e-14
Identities = 92/365 (25%), Positives = 139/365 (37%), Gaps = 74/365 (20%)
Query: 578 NRRRELELQTVDENAGYFSQDSSPTRLY------SHPANRSET----------TATSETD 621
N R +E + E SQ++ P Y P N + T TD
Sbjct: 254 NPRESMEKTGISEEFDRLSQEALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTD 313
Query: 622 YDTEPFNDYFNANYLRLPQINPDFN--------YIATQAPLPSTIDDFWNVVLSKNLKVI 673
P +DY NA+Y+R N +IATQ L +TI DFW++V +N +VI
Sbjct: 314 RPNTPGSDYINASYVRFENSQRTKNVTFACEKSFIATQGCLETTISDFWSMVWQENSRVI 373
Query: 674 ISLNSYDELDMKKWDIYWNSKSIRKHEV------------KVTNTYEDVFDIPGCILRVM 721
+ +E +K YW ++ + K EV KV D +
Sbjct: 374 VMPTMENERK-EKCARYWPAE-VNKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTN 431
Query: 722 NVSKS---DSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLD-SCGINMRDFIHIYH 777
++K ++ + L +K + QLQY W D C + H Y
Sbjct: 432 RIAKGLVPEAELNGDGISYILRTLVMKKGKDTREIRQLQYLTWPDHGCPL------HPYA 485
Query: 778 IKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFIT 837
+ N L ED Y + + P++VHCSAG GRTG +
Sbjct: 486 VLNFL---------------EDVDREYDYFNAQPIAASLPQGPIVVHCSAGIGRTGTVLV 530
Query: 838 LDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEFF 897
LD LL NQ K+ + + ++ +V +R R +VQ QY Y+++ F
Sbjct: 531 LDALL-------NQVKKVGL--LCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALA--F 579
Query: 898 YLKEH 902
YLK +
Sbjct: 580 YLKNN 584
>Hs5729993 [T] KOG4228 Protein tyrosine phosphatase
Length = 700
Score = 78.6 bits (192), Expect = 4e-14
Identities = 85/327 (25%), Positives = 135/327 (40%), Gaps = 72/327 (22%)
Query: 572 NLTPGGNRRRELELQTVDENAGYFSQDSSPTRLYSHPANRSETTATSETDYDTEPFNDYF 631
N P G+ + EL +EN ++ P L P + S + D P +DY
Sbjct: 140 NSLPSGHIQGTFELANKEENR---EKNRYPNIL---PNDHSRVILSQ---LDGIPCSDYI 190
Query: 632 NANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYW 691
NA+Y+ +IA Q P T++DFW +V + I+ L + E +K YW
Sbjct: 191 NASYI--DGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYW 248
Query: 692 NSKSIRKHEVKVTNTYEDV-FDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRP 750
+ TY ++ + C++ V D I+ K QLP ++ P
Sbjct: 249 PDQGCW--------TYGNIRVCVEDCVVLV------DYTIR---KFCIQPQLPDGCKA-P 290
Query: 751 HTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLL 810
V QL +T W D G+ + +K + KT + +H
Sbjct: 291 RLVSQLHFTSWPDF-GVPFTPIGMLKFLKKV--------------KTLNPVHA------- 328
Query: 811 SVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVN 870
P++VHCSAG GRTG FI +D ++ ++ + K+DV F V+
Sbjct: 329 --------GPIVVHCSAGVGRTGTFIVIDAMMAMM----HAEQKVDV--------FEFVS 368
Query: 871 ELRKQRISMVQNLTQYLTCYESMLEFF 897
+R QR MVQ QY Y+++LE++
Sbjct: 369 RIRNQRPQMVQTDMQYTFIYQALLEYY 395
Score = 69.3 bits (168), Expect = 2e-11
Identities = 68/272 (25%), Positives = 105/272 (38%), Gaps = 58/272 (21%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
+ + DY NA+++ + D+ +IATQ PL T++DFW ++ I+ L E +
Sbjct: 476 QEYTDYINASFIDGYR-QKDY-FIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 533
Query: 685 KKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPV 744
K YW ++ H ++T + + N + S++ I + +Q
Sbjct: 534 DKCYQYWPTEGSVTHG-EIT-------------IEIKNDTLSEA-ISIRDFLVTLNQPQA 578
Query: 745 KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTY 804
+ E + V Q + W P A D +
Sbjct: 579 RQEEQVRVVRQFHFHGW------------------------PEIGIPAEGKGMIDLIAAV 614
Query: 805 RKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADL 864
+K + P+ VHCSAG GRTG FI L +L R +DV
Sbjct: 615 QKQ-----QQQTGNHPITVHCSAGAGRTGTFIALSNIL----ERVKAEGLLDV------- 658
Query: 865 IFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
F V LR QR MVQ L QY CY+ + +F
Sbjct: 659 -FQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF 689
>Hs18860859 [T] KOG4228 Protein tyrosine phosphatase
Length = 642
Score = 78.6 bits (192), Expect = 4e-14
Identities = 85/327 (25%), Positives = 135/327 (40%), Gaps = 72/327 (22%)
Query: 572 NLTPGGNRRRELELQTVDENAGYFSQDSSPTRLYSHPANRSETTATSETDYDTEPFNDYF 631
N P G+ + EL +EN ++ P L P + S + D P +DY
Sbjct: 82 NSLPSGHIQGTFELANKEENR---EKNRYPNIL---PNDHSRVILSQ---LDGIPCSDYI 132
Query: 632 NANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYW 691
NA+Y+ +IA Q P T++DFW +V + I+ L + E +K YW
Sbjct: 133 NASYI--DGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYW 190
Query: 692 NSKSIRKHEVKVTNTYEDV-FDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRP 750
+ TY ++ + C++ V D I+ K QLP ++ P
Sbjct: 191 PDQGCW--------TYGNIRVCVEDCVVLV------DYTIR---KFCIQPQLPDGCKA-P 232
Query: 751 HTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLL 810
V QL +T W D G+ + +K + KT + +H
Sbjct: 233 RLVSQLHFTSWPDF-GVPFTPIGMLKFLKKV--------------KTLNPVHA------- 270
Query: 811 SVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVN 870
P++VHCSAG GRTG FI +D ++ ++ + K+DV F V+
Sbjct: 271 --------GPIVVHCSAGVGRTGTFIVIDAMMAMM----HAEQKVDV--------FEFVS 310
Query: 871 ELRKQRISMVQNLTQYLTCYESMLEFF 897
+R QR MVQ QY Y+++LE++
Sbjct: 311 RIRNQRPQMVQTDMQYTFIYQALLEYY 337
Score = 69.3 bits (168), Expect = 2e-11
Identities = 68/272 (25%), Positives = 105/272 (38%), Gaps = 58/272 (21%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
+ + DY NA+++ + D+ +IATQ PL T++DFW ++ I+ L E +
Sbjct: 418 QEYTDYINASFIDGYR-QKDY-FIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 475
Query: 685 KKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPV 744
K YW ++ H ++T + + N + S++ I + +Q
Sbjct: 476 DKCYQYWPTEGSVTHG-EIT-------------IEIKNDTLSEA-ISIRDFLVTLNQPQA 520
Query: 745 KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTY 804
+ E + V Q + W P A D +
Sbjct: 521 RQEEQVRVVRQFHFHGW------------------------PEIGIPAEGKGMIDLIAAV 556
Query: 805 RKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADL 864
+K + P+ VHCSAG GRTG FI L +L R +DV
Sbjct: 557 QKQ-----QQQTGNHPITVHCSAGAGRTGTFIALSNIL----ERVKAEGLLDV------- 600
Query: 865 IFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
F V LR QR MVQ L QY CY+ + +F
Sbjct: 601 -FQAVKSLRLQRPHMVQTLEQYEFCYKVVQDF 631
>Hs18860902 [T] KOG4228 Protein tyrosine phosphatase
Length = 1440
Score = 78.2 bits (191), Expect = 5e-14
Identities = 71/273 (26%), Positives = 118/273 (43%), Gaps = 65/273 (23%)
Query: 623 DTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDEL 682
+ +P +DY NANY+ Q P +YIATQ P+ T+ DFW ++ + I+ + + E+
Sbjct: 934 EDDPSSDYINANYIDGYQ-RPS-HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEV 991
Query: 683 DMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQL 742
K YW + + KVT ++ + ++R + +
Sbjct: 992 GRVKCYKYWPDDTEVYGDFKVTCV--EMEPLAEYVVRTFTLERRGY-------------- 1035
Query: 743 PVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLH 802
NE R V Q +T W D G+ YH LL F+
Sbjct: 1036 ---NEIRE--VKQFHFTGWPDH-GVP-------YHATGLL----------------SFIR 1066
Query: 803 TYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSA 862
+ ++ S P++VHCSAG GRTG +I +D +L + + + +D++N
Sbjct: 1067 RVK------LSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDM----AEREGVVDIYN--- 1113
Query: 863 DLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V LR +RI+MVQ QY+ ++++LE
Sbjct: 1114 -----CVKALRSRRINMVQTEEQYIFIHDAILE 1141
>Hs18641364 [T] KOG4228 Protein tyrosine phosphatase
Length = 1256
Score = 77.8 bits (190), Expect = 7e-14
Identities = 73/270 (27%), Positives = 117/270 (43%), Gaps = 63/270 (23%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
++Y NA+Y+ YIA Q P T+DDFW ++ + VI+ + +E + K
Sbjct: 655 SNYINASYI--DGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKC 712
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKS-DSRIQSPNKRTKFDQLPVKN 746
YW S + T + DV ++++ + D IQ N K K
Sbjct: 713 AEYWPSME------EGTRAFGDV------VVKINQHKRCPDYIIQKLNIVNK------KE 754
Query: 747 ESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRK 806
++ V +Q+T W D G+ DP L L R+
Sbjct: 755 KATGREVTHIQFTSWPDH-GVP---------------EDPHLL-----------LKLRRR 787
Query: 807 LGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIF 866
+ S N P++VHCSAG GRTG +I +D +L L++ NK+DV+
Sbjct: 788 VNAFS---NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEA----ENKVDVYG------- 833
Query: 867 IVVNELRKQRISMVQNLTQYLTCYESMLEF 896
V +LR+QR MVQ QY+ +++++E+
Sbjct: 834 -YVVKLRRQRCLMVQVEAQYILIHQALVEY 862
Score = 77.4 bits (189), Expect = 9e-14
Identities = 90/380 (23%), Positives = 141/380 (36%), Gaps = 119/380 (31%)
Query: 513 LGNYQMTKGIQSFTKNRYSNILPYEHSRVRLQPSPLAEXXXXXXXXXXXXXAPKSGKYDN 572
+GN + K +KNR SN++PY+++RV L
Sbjct: 912 IGNQEENK-----SKNRNSNVIPYDYNRVPL----------------------------- 937
Query: 573 LTPGGNRRRELELQTVDENAGYFSQDSSPTRLYSHPANRSETTATSETDYDTEPFNDYFN 632
+ ELE+ E+ ++ +S+ D D+E + Y N
Sbjct: 938 -------KHELEMSKESEH---------------------DSDESSDDDSDSEEPSKYIN 969
Query: 633 ANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWN 692
A+++ + P+ IA Q PL TI DFW ++ + +KVI+ L D + YW
Sbjct: 970 ASFI-MSYWKPEV-MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG 1027
Query: 693 SKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHT 752
TY D+ V D+ S F+ K + T
Sbjct: 1028 EGK---------QTYGDI-----------EVDLKDTDKSSTYTLRVFELRHSKRKD-SRT 1066
Query: 753 VYQLQYTKW-LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLS 811
VYQ QYT W ++ ++ I + + L N +E
Sbjct: 1067 VYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQ--------KNSSEG------------ 1106
Query: 812 VNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNE 871
NK++ +P+L+HC G +TG+F LL +L+S + +D IF VV
Sbjct: 1107 -NKHHKSTPLLIHCRDGSQQTGIFCA---LLNLLESAETE-EVVD--------IFQVVKA 1153
Query: 872 LRKQRISMVQNLTQYLTCYE 891
LRK R MV QY Y+
Sbjct: 1154 LRKARPGMVSTFEQYQFLYD 1173
>Hs18641362 [T] KOG4228 Protein tyrosine phosphatase
Length = 1143
Score = 77.8 bits (190), Expect = 7e-14
Identities = 73/270 (27%), Positives = 117/270 (43%), Gaps = 63/270 (23%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
++Y NA+Y+ YIA Q P T+DDFW ++ + VI+ + +E + K
Sbjct: 542 SNYINASYI--DGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKC 599
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKS-DSRIQSPNKRTKFDQLPVKN 746
YW S + T + DV ++++ + D IQ N K K
Sbjct: 600 AEYWPSME------EGTRAFGDV------VVKINQHKRCPDYIIQKLNIVNK------KE 641
Query: 747 ESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRK 806
++ V +Q+T W D G+ DP L L R+
Sbjct: 642 KATGREVTHIQFTSWPDH-GVP---------------EDPHLL-----------LKLRRR 674
Query: 807 LGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIF 866
+ S N P++VHCSAG GRTG +I +D +L L++ NK+DV+
Sbjct: 675 VNAFS---NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEA----ENKVDVYG------- 720
Query: 867 IVVNELRKQRISMVQNLTQYLTCYESMLEF 896
V +LR+QR MVQ QY+ +++++E+
Sbjct: 721 -YVVKLRRQRCLMVQVEAQYILIHQALVEY 749
Score = 77.4 bits (189), Expect = 9e-14
Identities = 90/380 (23%), Positives = 141/380 (36%), Gaps = 119/380 (31%)
Query: 513 LGNYQMTKGIQSFTKNRYSNILPYEHSRVRLQPSPLAEXXXXXXXXXXXXXAPKSGKYDN 572
+GN + K +KNR SN++PY+++RV L
Sbjct: 799 IGNQEENK-----SKNRNSNVIPYDYNRVPL----------------------------- 824
Query: 573 LTPGGNRRRELELQTVDENAGYFSQDSSPTRLYSHPANRSETTATSETDYDTEPFNDYFN 632
+ ELE+ E+ ++ +S+ D D+E + Y N
Sbjct: 825 -------KHELEMSKESEH---------------------DSDESSDDDSDSEEPSKYIN 856
Query: 633 ANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWN 692
A+++ + P+ IA Q PL TI DFW ++ + +KVI+ L D + YW
Sbjct: 857 ASFI-MSYWKPEV-MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG 914
Query: 693 SKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHT 752
TY D+ V D+ S F+ K + T
Sbjct: 915 EGK---------QTYGDI-----------EVDLKDTDKSSTYTLRVFELRHSKRKD-SRT 953
Query: 753 VYQLQYTKW-LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLS 811
VYQ QYT W ++ ++ I + + L N +E
Sbjct: 954 VYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQ--------KNSSEG------------ 993
Query: 812 VNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNE 871
NK++ +P+L+HC G +TG+F LL +L+S + +D IF VV
Sbjct: 994 -NKHHKSTPLLIHCRDGSQQTGIFCA---LLNLLESAETE-EVVD--------IFQVVKA 1040
Query: 872 LRKQRISMVQNLTQYLTCYE 891
LRK R MV QY Y+
Sbjct: 1041 LRKARPGMVSTFEQYQFLYD 1060
>Hs18641347 [T] KOG4228 Protein tyrosine phosphatase
Length = 1304
Score = 77.8 bits (190), Expect = 7e-14
Identities = 73/270 (27%), Positives = 117/270 (43%), Gaps = 63/270 (23%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
++Y NA+Y+ YIA Q P T+DDFW ++ + VI+ + +E + K
Sbjct: 703 SNYINASYI--DGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKC 760
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKS-DSRIQSPNKRTKFDQLPVKN 746
YW S + T + DV ++++ + D IQ N K K
Sbjct: 761 AEYWPSME------EGTRAFGDV------VVKINQHKRCPDYIIQKLNIVNK------KE 802
Query: 747 ESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRK 806
++ V +Q+T W D G+ DP L L R+
Sbjct: 803 KATGREVTHIQFTSWPDH-GVP---------------EDPHLL-----------LKLRRR 835
Query: 807 LGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIF 866
+ S N P++VHCSAG GRTG +I +D +L L++ NK+DV+
Sbjct: 836 VNAFS---NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEA----ENKVDVYG------- 881
Query: 867 IVVNELRKQRISMVQNLTQYLTCYESMLEF 896
V +LR+QR MVQ QY+ +++++E+
Sbjct: 882 -YVVKLRRQRCLMVQVEAQYILIHQALVEY 910
Score = 77.4 bits (189), Expect = 9e-14
Identities = 90/380 (23%), Positives = 141/380 (36%), Gaps = 119/380 (31%)
Query: 513 LGNYQMTKGIQSFTKNRYSNILPYEHSRVRLQPSPLAEXXXXXXXXXXXXXAPKSGKYDN 572
+GN + K +KNR SN++PY+++RV L
Sbjct: 960 IGNQEENK-----SKNRNSNVIPYDYNRVPL----------------------------- 985
Query: 573 LTPGGNRRRELELQTVDENAGYFSQDSSPTRLYSHPANRSETTATSETDYDTEPFNDYFN 632
+ ELE+ E+ ++ +S+ D D+E + Y N
Sbjct: 986 -------KHELEMSKESEH---------------------DSDESSDDDSDSEEPSKYIN 1017
Query: 633 ANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWN 692
A+++ + P+ IA Q PL TI DFW ++ + +KVI+ L D + YW
Sbjct: 1018 ASFI-MSYWKPEV-MIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWG 1075
Query: 693 SKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHT 752
TY D+ V D+ S F+ K + T
Sbjct: 1076 EGK---------QTYGDI-----------EVDLKDTDKSSTYTLRVFELRHSKRKD-SRT 1114
Query: 753 VYQLQYTKW-LDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLS 811
VYQ QYT W ++ ++ I + + L N +E
Sbjct: 1115 VYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQ--------KNSSEG------------ 1154
Query: 812 VNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNE 871
NK++ +P+L+HC G +TG+F LL +L+S + +D IF VV
Sbjct: 1155 -NKHHKSTPLLIHCRDGSQQTGIFCA---LLNLLESAETE-EVVD--------IFQVVKA 1201
Query: 872 LRKQRISMVQNLTQYLTCYE 891
LRK R MV QY Y+
Sbjct: 1202 LRKARPGMVSTFEQYQFLYD 1221
>CE29408 [T] KOG4228 Protein tyrosine phosphatase
Length = 1442
Score = 77.8 bits (190), Expect = 7e-14
Identities = 70/281 (24%), Positives = 120/281 (41%), Gaps = 57/281 (20%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
+ ++DY NAN+++ + F IA QAP+ +TI DFW +V + +I+ + + E +
Sbjct: 873 DDYSDYINANFIKSWKEKKLF--IAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNR 930
Query: 685 KKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCI--LRVMNVSKSDSRIQSPNKRTKFDQL 742
++ YW + I ++ + F I + ++ + + ++ +
Sbjct: 931 QQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGPDVIPNGNGVEYANV 990
Query: 743 PV-----KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKT 797
P+ N SR + Q +T W D + A T
Sbjct: 991 PIVKGQFANNSR--RILQYHFTNWND--------------------------YKAPECST 1022
Query: 798 EDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLG--VLDSRSNQSNKI 855
YR L N SPV++HCSAG GRTG FI++D +L + + ++N
Sbjct: 1023 GLLRFMYRLRELPQFNN----SPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKAN----- 1073
Query: 856 DVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
IF V LR+QR MVQ+L QY+ Y+++ E+
Sbjct: 1074 ---------IFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW 1105
>CE26369 [T] KOG4228 Protein tyrosine phosphatase
Length = 1407
Score = 77.8 bits (190), Expect = 7e-14
Identities = 70/281 (24%), Positives = 120/281 (41%), Gaps = 57/281 (20%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
+ ++DY NAN+++ + F IA QAP+ +TI DFW +V + +I+ + + E +
Sbjct: 838 DDYSDYINANFIKSWKEKKLF--IAAQAPVDATIGDFWRMVWEQESYLIVMVANLTEKNR 895
Query: 685 KKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCI--LRVMNVSKSDSRIQSPNKRTKFDQL 742
++ YW + I ++ + F I + ++ + + ++ +
Sbjct: 896 QQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGECGPDVIPNGNGVEYANV 955
Query: 743 PV-----KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKT 797
P+ N SR + Q +T W D + A T
Sbjct: 956 PIVKGQFANNSR--RILQYHFTNWND--------------------------YKAPECST 987
Query: 798 EDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLG--VLDSRSNQSNKI 855
YR L N SPV++HCSAG GRTG FI++D +L + + ++N
Sbjct: 988 GLLRFMYRLRELPQFNN----SPVVIHCSAGVGRTGTFISIDSMLDQCLAEDKAN----- 1038
Query: 856 DVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
IF V LR+QR MVQ+L QY+ Y+++ E+
Sbjct: 1039 ---------IFEFVCNLRRQRNLMVQSLEQYVFIYKALAEW 1070
>SPAC11E3.09 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 303
Score = 75.1 bits (183), Expect = 5e-13
Identities = 71/277 (25%), Positives = 116/277 (41%), Gaps = 56/277 (20%)
Query: 629 DYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLK--VIISLNSYDELDMKK 686
DY NA+ +++P +IATQ P ++ID FW +V K +I+ L E K
Sbjct: 77 DYINASIVKIPSGK---TFIATQGPTSNSIDVFWKMVWQSVPKSGIIVMLTKLRERHRLK 133
Query: 687 WDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKN 746
DIYW V++ T ++ D+ +++V ++ + + + +
Sbjct: 134 CDIYW--------PVELFETL-NIGDLSVILVKVYTLTSLNE--------VQVREFELNK 176
Query: 747 ESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRK 806
+ + Y W D F A + T L R
Sbjct: 177 DGVKKKILHFYYNGWPD--------------------------FGAPH--TFSLLSLTRY 208
Query: 807 LGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIF 866
+ LS + + +P++VHCSAGCGRTG F+ L +L D S ++K +V D I
Sbjct: 209 IKSLSYSPDFETAPIIVHCSAGCGRTGTFMALFEILSQTDD-STSTSKFEV-----DNIA 262
Query: 867 IVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEHI 903
+V+ LR QR+ VQ++ Q + Y E KE +
Sbjct: 263 NIVSSLRSQRMQSVQSVDQLVFLYTVSQELLQGKEFL 299
>7291964 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM
domain
Length = 916
Score = 74.7 bits (182), Expect = 6e-13
Identities = 75/296 (25%), Positives = 119/296 (39%), Gaps = 77/296 (26%)
Query: 629 DYFNANYLRLPQINPDFN-YIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
DY NANY+ + N YIATQ PL ST DFW +V ++ +++ L + E +K
Sbjct: 634 DYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKC 693
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW T E++ G +R ++ ++ F + +K++
Sbjct: 694 HQYWPV------------TGEELQLAEGFSVRCLSEKPDETG------SFVFREFVLKDK 735
Query: 748 SRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNN----KTEDFLHT 803
++ +QY W D C + NL L + A N + E+ L
Sbjct: 736 HEQRHIHHMQYLAWPDHC---------VPSDPNLFLEFTERVRAARNRTLLQEIEESLKQ 786
Query: 804 YRKL----------GLLSVNK-----------------------NNSGSPVLVHCSAGCG 830
R + GL+ K + + PV+VHCSAG G
Sbjct: 787 VRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIG 846
Query: 831 RTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQY 886
RTGV I +D L ++++R V+ + +V +R QR MVQN++QY
Sbjct: 847 RTGVLILMDTALALMEARE------PVYPLD------IVRTMRDQRACMVQNVSQY 890
>Hs5453992 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 2466
Score = 73.9 bits (180), Expect = 1e-12
Identities = 71/294 (24%), Positives = 114/294 (38%), Gaps = 74/294 (25%)
Query: 610 NRSETTATSETDYDTE--PFND---YFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNV 664
NR + + YD P D Y NA+++++P +F YIA Q PLP+T+ DFW +
Sbjct: 2218 NRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQM 2277
Query: 665 VLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYE----DVFDIPGCILRV 720
+ + VI + E + K YW +I V+N + + G ++R
Sbjct: 2278 IWEQKSTVIAMMTQEVEGEKIKCQRYW--PNILGKTTMVSNRLRLALVRMQQLKGFVVRA 2335
Query: 721 MNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKN 780
M + +R + L +T W D
Sbjct: 2336 MTLEDIQTR-------------------EVRHISHLNFTAWPD----------------- 2359
Query: 781 LLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDF 840
+D S + L H +R P++ HCSAG GR+G I +D
Sbjct: 2360 ---HDTPSQPDDLLTFISYMRHIHR------------SGPIITHCSAGIGRSGTLICIDV 2404
Query: 841 LLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESML 894
+LG++ +Q D+ ++ V +R QR MVQ QY+ CY+ +L
Sbjct: 2405 VLGLI----SQDLDFDISDL--------VRCMRLQRHGMVQTEDQYIFCYQVIL 2446
>Hs19743931 [T] KOG4228 Protein tyrosine phosphatase
Length = 1440
Score = 73.9 bits (180), Expect = 1e-12
Identities = 68/276 (24%), Positives = 119/276 (42%), Gaps = 69/276 (25%)
Query: 625 EPFNDYFNANYLRLPQINPDF-----NYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSY 679
+P DY NANY+ + +IN + ++IATQ P P + DFW +V ++ I+ +
Sbjct: 928 DPNADYINANYIDI-RINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKL 986
Query: 680 DELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKF 739
E+ K YW S +TY D+ ++M V K+++ + +
Sbjct: 987 VEVGRVKCSRYWPEDS---------DTYGDI--------KIMLV-KTETLAEYVVRTFAL 1028
Query: 740 DQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTED 799
++ + S H V Q +T W + G+ YH LL
Sbjct: 1029 ER---RGYSARHEVRQFHFTAWPEH-GVP-------YHATGLLA---------------- 1061
Query: 800 FLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWN 859
F+ + + P+++HCSAG GRTG +I LD +L + + +D++N
Sbjct: 1062 FIRRVK------ASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC----EGVVDIYN 1111
Query: 860 MSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V L +R++M+Q QY+ ++++LE
Sbjct: 1112 --------CVKTLCSRRVNMIQTEEQYIFIHDAILE 1139
>Hs18375650 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 2490
Score = 73.9 bits (180), Expect = 1e-12
Identities = 71/294 (24%), Positives = 114/294 (38%), Gaps = 74/294 (25%)
Query: 610 NRSETTATSETDYDTE--PFND---YFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNV 664
NR + + YD P D Y NA+++++P +F YIA Q PLP+T+ DFW +
Sbjct: 2242 NRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQM 2301
Query: 665 VLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYE----DVFDIPGCILRV 720
+ + VI + E + K YW +I V+N + + G ++R
Sbjct: 2302 IWEQKSTVIAMMTQEVEGEKIKCQRYW--PNILGKTTMVSNRLRLALVRMQQLKGFVVRA 2359
Query: 721 MNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKN 780
M + +R + L +T W D
Sbjct: 2360 MTLEDIQTR-------------------EVRHISHLNFTAWPD----------------- 2383
Query: 781 LLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDF 840
+D S + L H +R P++ HCSAG GR+G I +D
Sbjct: 2384 ---HDTPSQPDDLLTFISYMRHIHR------------SGPIITHCSAGIGRSGTLICIDV 2428
Query: 841 LLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESML 894
+LG++ +Q D+ ++ V +R QR MVQ QY+ CY+ +L
Sbjct: 2429 VLGLI----SQDLDFDISDL--------VRCMRLQRHGMVQTEDQYIFCYQVIL 2470
>Hs18375648 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 2294
Score = 73.9 bits (180), Expect = 1e-12
Identities = 71/294 (24%), Positives = 114/294 (38%), Gaps = 74/294 (25%)
Query: 610 NRSETTATSETDYDTE--PFND---YFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNV 664
NR + + YD P D Y NA+++++P +F YIA Q PLP+T+ DFW +
Sbjct: 2046 NRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQM 2105
Query: 665 VLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYE----DVFDIPGCILRV 720
+ + VI + E + K YW +I V+N + + G ++R
Sbjct: 2106 IWEQKSTVIAMMTQEVEGEKIKCQRYW--PNILGKTTMVSNRLRLALVRMQQLKGFVVRA 2163
Query: 721 MNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKN 780
M + +R + L +T W D
Sbjct: 2164 MTLEDIQTR-------------------EVRHISHLNFTAWPD----------------- 2187
Query: 781 LLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDF 840
+D S + L H +R P++ HCSAG GR+G I +D
Sbjct: 2188 ---HDTPSQPDDLLTFISYMRHIHR------------SGPIITHCSAGIGRSGTLICIDV 2232
Query: 841 LLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESML 894
+LG++ +Q D+ ++ V +R QR MVQ QY+ CY+ +L
Sbjct: 2233 VLGLI----SQDLDFDISDL--------VRCMRLQRHGMVQTEDQYIFCYQVIL 2274
>Hs18375646 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 2485
Score = 73.9 bits (180), Expect = 1e-12
Identities = 71/294 (24%), Positives = 114/294 (38%), Gaps = 74/294 (25%)
Query: 610 NRSETTATSETDYDTE--PFND---YFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNV 664
NR + + YD P D Y NA+++++P +F YIA Q PLP+T+ DFW +
Sbjct: 2237 NRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQM 2296
Query: 665 VLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYE----DVFDIPGCILRV 720
+ + VI + E + K YW +I V+N + + G ++R
Sbjct: 2297 IWEQKSTVIAMMTQEVEGEKIKCQRYW--PNILGKTTMVSNRLRLALVRMQQLKGFVVRA 2354
Query: 721 MNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKN 780
M + +R + L +T W D
Sbjct: 2355 MTLEDIQTR-------------------EVRHISHLNFTAWPD----------------- 2378
Query: 781 LLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDF 840
+D S + L H +R P++ HCSAG GR+G I +D
Sbjct: 2379 ---HDTPSQPDDLLTFISYMRHIHR------------SGPIITHCSAGIGRSGTLICIDV 2423
Query: 841 LLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESML 894
+LG++ +Q D+ ++ V +R QR MVQ QY+ CY+ +L
Sbjct: 2424 VLGLI----SQDLDFDISDL--------VRCMRLQRHGMVQTEDQYIFCYQVIL 2465
>CE15903 [T] KOG0789 Protein tyrosine phosphatase
Length = 490
Score = 73.9 bits (180), Expect = 1e-12
Identities = 71/314 (22%), Positives = 126/314 (39%), Gaps = 76/314 (24%)
Query: 591 NAGYFSQDSSPTRLYSHPANRSETTATSETDYDTEPFNDYFNANYLRLPQINPDFNYIAT 650
N Y + D++P E T ++D DY +A+++R+P + YI T
Sbjct: 194 NCTYTAYDANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPGKDQS-TYITT 248
Query: 651 QAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSK-----SIRKHEVKVTN 705
Q PLP T+ DFW+++ + + ++ L + E ++K +Y+ K K+E+ +T
Sbjct: 249 QGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTE 308
Query: 706 TYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSC 765
E+ I G I + V+ ++ S P + +Q W D
Sbjct: 309 CKEEA--IAGTIWNALTVTNTEDA-----------------SSEPLYMNHVQVPWWPDQL 349
Query: 766 G-INMRDFIHIYH-IKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLV 823
+ R I +Y +K + N +P+ V
Sbjct: 350 APEDARPMIELYKWVKKV---------------------------------NPKETPICV 376
Query: 824 HCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNL 883
HCSAG GRT F+ +D+ R ++ I++ + +V E+R R VQ+
Sbjct: 377 HCSAGVGRTATFVGIDY----ATIRIMENPNIEMLD--------IVREMRAMRFQAVQSH 424
Query: 884 TQYLTCYESMLEFF 897
Q+L Y ++E+F
Sbjct: 425 MQFLFLYVVLMEYF 438
>CE03335 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1367
Score = 73.9 bits (180), Expect = 1e-12
Identities = 83/303 (27%), Positives = 121/303 (39%), Gaps = 78/303 (25%)
Query: 608 PANRSETTATSETDYD------TEPFN----DYFNANYLRLPQINPDFNYIATQAPLPST 657
P NR + T+ YD + P N DY NANY+ P + +IA Q PLP+T
Sbjct: 1094 PINRPKNRFTNIPSYDHSRVKLSNPNNIEGGDYINANYV--PGFSSRREFIAAQGPLPTT 1151
Query: 658 IDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYW---NSKSIRKHEVKVTNTYEDVFDIP 714
D FW + + II+L E K YW + + +++VT E FD
Sbjct: 1152 RDHFWQMTWEQQCPAIIALTKCVEKGRDKCHQYWPDHENVPVLYGDIEVTIVAEKEFD-- 1209
Query: 715 GCILRVMNVSKS--DSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDF 772
++R + + KS D R+ T+F V Y W D
Sbjct: 1210 EFVIRDIRLEKSGPDGRV------TRF-------------VRHWHYMAWPDF-------- 1242
Query: 773 IHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRT 832
S N + + F H + + +P +VHCSAG GR+
Sbjct: 1243 ------------GAPSHPNGIIQFSRMFRH--------HLPHSPHNAPTIVHCSAGVGRS 1282
Query: 833 GVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYES 892
G FI++D LL S+ + IDV F V E+R +R MVQN QY+ +
Sbjct: 1283 GTFISIDRLL----QSSSFGDPIDV--------FGTVCEMRYERCQMVQNEQQYIFIHYC 1330
Query: 893 MLE 895
+L+
Sbjct: 1331 ILQ 1333
>Hs19743935 [T] KOG4228 Protein tyrosine phosphatase
Length = 1446
Score = 73.6 bits (179), Expect = 1e-12
Identities = 66/271 (24%), Positives = 115/271 (42%), Gaps = 65/271 (23%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
+P DY NANY+ + ++IATQ P P + DFW +V ++ I+ + E+
Sbjct: 938 DPNADYINANYI--DGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGR 995
Query: 685 KKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPV 744
K YW S +TY D+ ++M V K+++ + + ++
Sbjct: 996 VKCSRYWPEDS---------DTYGDI--------KIMLV-KTETLAEYVVRTFALER--- 1034
Query: 745 KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTY 804
+ S H V Q +T W + G+ YH LL F+
Sbjct: 1035 RGYSARHEVRQFHFTAWPEH-GVP-------YHATGLLA----------------FIRRV 1070
Query: 805 RKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADL 864
+ + P+++HCSAG GRTG +I LD +L + + +D++N
Sbjct: 1071 K------ASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC----EGVVDIYN----- 1115
Query: 865 IFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V L +R++M+Q QY+ ++++LE
Sbjct: 1116 ---CVKTLCSRRVNMIQTEEQYIFIHDAILE 1143
>Hs19743933 [T] KOG4228 Protein tyrosine phosphatase
Length = 1436
Score = 73.6 bits (179), Expect = 1e-12
Identities = 66/271 (24%), Positives = 115/271 (42%), Gaps = 65/271 (23%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
+P DY NANY+ + ++IATQ P P + DFW +V ++ I+ + E+
Sbjct: 928 DPNADYINANYI--DGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGR 985
Query: 685 KKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPV 744
K YW S +TY D+ ++M V K+++ + + ++
Sbjct: 986 VKCSRYWPEDS---------DTYGDI--------KIMLV-KTETLAEYVVRTFALER--- 1024
Query: 745 KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTY 804
+ S H V Q +T W + G+ YH LL F+
Sbjct: 1025 RGYSARHEVRQFHFTAWPEH-GVP-------YHATGLLA----------------FIRRV 1060
Query: 805 RKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADL 864
+ + P+++HCSAG GRTG +I LD +L + + +D++N
Sbjct: 1061 K------ASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC----EGVVDIYN----- 1105
Query: 865 IFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
V L +R++M+Q QY+ ++++LE
Sbjct: 1106 ---CVKTLCSRRVNMIQTEEQYIFIHDAILE 1133
>CE16864 [T] KOG0789 Protein tyrosine phosphatase
Length = 374
Score = 73.6 bits (179), Expect = 1e-12
Identities = 70/273 (25%), Positives = 107/273 (38%), Gaps = 61/273 (22%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY +AN++ P + PD +I TQ PL T+DDFW +++ + ++ I+ L E K
Sbjct: 133 SDYVHANFVGCPMV-PDKRFICTQGPLDHTVDDFWWMIVQQKVEQIVMLCKTIETGKYKC 191
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW K EVK E+V S ++ + + L V
Sbjct: 192 AQYWPLAMGEKKEVKGGIVVENV---------------SGTKPMDRDAEIQITTLQVSFG 236
Query: 748 SRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRKL 807
+ +V L ++ W D G+ P L L
Sbjct: 237 DQKMSVRHLHWSDWPDR-GV-----------------PPCKL---------------TSL 263
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFI 867
LLS + S P++VHCSAG GRTG + ++++L + D
Sbjct: 264 ELLSAVR-GSRVPIVVHCSAGIGRTGTIVAIEYILERIAENKQCPPMPD----------- 311
Query: 868 VVNELRKQRISMVQNLTQYLTCYESMLEFFYLK 900
+V LR QR +Q QYL + ML +F K
Sbjct: 312 LVKSLRDQRAYSIQTDMQYLYIHRVMLNYFLEK 344
>Hs4506291 [T] KOG0789 Protein tyrosine phosphatase
Length = 415
Score = 73.2 bits (178), Expect = 2e-12
Identities = 76/301 (25%), Positives = 115/301 (37%), Gaps = 65/301 (21%)
Query: 601 PTRLYSHPANRSETTATSETDYDTEPF------NDYFNANYLRLPQINPDFNYIATQAPL 654
P R+ P NR+ + YD NDY NA+ + + + +YI TQ PL
Sbjct: 33 PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQR--SYILTQGPL 90
Query: 655 PSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIP 714
P+T FW +V + K ++ LN E + K YW T+ E +F
Sbjct: 91 PNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYW-----------PTDDQEMLFKET 139
Query: 715 GCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIH 774
G ++++ S QL N T+ YT W D G+
Sbjct: 140 GFSVKLL------SEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPD-FGVP------ 186
Query: 775 IYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGV 834
PAS N FL R+ G L N P ++HCSAG GR+G
Sbjct: 187 ---------ESPASFLN--------FLFKVRESGSL----NPDHGPAVIHCSAGIGRSGT 225
Query: 835 FITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESML 894
F +D L +++ + + K + NM RK R+ ++Q Q Y +++
Sbjct: 226 FSLVDTCLVLMEKGDDINIKQVLLNM------------RKYRMGLIQTPDQLRFSYMAII 273
Query: 895 E 895
E
Sbjct: 274 E 274
>Hs18104982 [T] KOG0789 Protein tyrosine phosphatase
Length = 353
Score = 73.2 bits (178), Expect = 2e-12
Identities = 76/301 (25%), Positives = 115/301 (37%), Gaps = 65/301 (21%)
Query: 601 PTRLYSHPANRSETTATSETDYDTEPF------NDYFNANYLRLPQINPDFNYIATQAPL 654
P R+ P NR+ + YD NDY NA+ + + + +YI TQ PL
Sbjct: 33 PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQR--SYILTQGPL 90
Query: 655 PSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIP 714
P+T FW +V + K ++ LN E + K YW T+ E +F
Sbjct: 91 PNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYW-----------PTDDQEMLFKET 139
Query: 715 GCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIH 774
G ++++ S QL N T+ YT W D G+
Sbjct: 140 GFSVKLL------SEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPD-FGVP------ 186
Query: 775 IYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGV 834
PAS N FL R+ G L N P ++HCSAG GR+G
Sbjct: 187 ---------ESPASFLN--------FLFKVRESGSL----NPDHGPAVIHCSAGIGRSGT 225
Query: 835 FITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESML 894
F +D L +++ + + K + NM RK R+ ++Q Q Y +++
Sbjct: 226 FSLVDTCLVLMEKGDDINIKQVLLNM------------RKYRMGLIQTPDQLRFSYMAII 273
Query: 895 E 895
E
Sbjct: 274 E 274
>Hs18104980 [T] KOG0789 Protein tyrosine phosphatase
Length = 387
Score = 73.2 bits (178), Expect = 2e-12
Identities = 76/301 (25%), Positives = 115/301 (37%), Gaps = 65/301 (21%)
Query: 601 PTRLYSHPANRSETTATSETDYDTEPF------NDYFNANYLRLPQINPDFNYIATQAPL 654
P R+ P NR+ + YD NDY NA+ + + + +YI TQ PL
Sbjct: 33 PHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQR--SYILTQGPL 90
Query: 655 PSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIP 714
P+T FW +V + K ++ LN E + K YW T+ E +F
Sbjct: 91 PNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYW-----------PTDDQEMLFKET 139
Query: 715 GCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIH 774
G ++++ S QL N T+ YT W D G+
Sbjct: 140 GFSVKLL------SEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPD-FGVP------ 186
Query: 775 IYHIKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGV 834
PAS N FL R+ G L N P ++HCSAG GR+G
Sbjct: 187 ---------ESPASFLN--------FLFKVRESGSL----NPDHGPAVIHCSAGIGRSGT 225
Query: 835 FITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESML 894
F +D L +++ + + K + NM RK R+ ++Q Q Y +++
Sbjct: 226 FSLVDTCLVLMEKGDDINIKQVLLNM------------RKYRMGLIQTPDQLRFSYMAII 273
Query: 895 E 895
E
Sbjct: 274 E 274
>CE11200 [T] KOG0789 Protein tyrosine phosphatase
Length = 518
Score = 72.8 bits (177), Expect = 2e-12
Identities = 65/276 (23%), Positives = 113/276 (40%), Gaps = 72/276 (26%)
Query: 629 DYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWD 688
DY +A+++R+P + YI TQ PLP T+ DFW+++ + + ++ L + E ++K
Sbjct: 229 DYIHASWMRMPGKDQS-TYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCA 287
Query: 689 IYWNSK-----SIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLP 743
+Y+ K K+E+ +T E+ I G IL + V ++
Sbjct: 288 LYYPEKLGEVVKFGKYEITLTECKEEA--IAGTILNSLTVINTEDA-------------- 331
Query: 744 VKNESRPHTVYQLQYTKWLDSCG-INMRDFIHIYH-IKNLLLNDPASLFNALNNKTEDFL 801
S P + +Q W D + R I +Y +K +
Sbjct: 332 ---TSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKV-------------------- 368
Query: 802 HTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMS 861
N P+ VHCSAG GRT F+ +D+ R ++ I++ +
Sbjct: 369 -------------NPKEKPICVHCSAGVGRTATFVGIDY----ATIRIMENPNIEMLD-- 409
Query: 862 ADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEFF 897
+V E+R R VQ+ Q+L Y ++E+F
Sbjct: 410 ------IVREMRAMRFQAVQSHMQFLFLYVVLMEYF 439
>SPAC19D5.01 [T] KOG0789 Protein tyrosine phosphatase
Length = 711
Score = 72.4 bits (176), Expect = 3e-12
Identities = 72/279 (25%), Positives = 108/279 (37%), Gaps = 84/279 (30%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVL--SKNLKVIISLNSYDELDMK 685
+DY NA+++ + + YIA QAP P T+ DFW +V S VI+ L + E +
Sbjct: 484 SDYINASHIDVG----NKKYIACQAPKPGTLLDFWEMVWHNSGTNGVIVMLTNLYEAGSE 539
Query: 686 KWDIYWNSK-------------SIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQS 732
K YW S++K+E T+ED + V+ R+
Sbjct: 540 KCSQYWPDNKDHALCLEGGLRISVQKYE-----TFED-----------LKVNTHLFRLDK 583
Query: 733 PNKRTKFDQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNA 792
PN K+ ++ W D ++ I + + ND
Sbjct: 584 PNGPPKY-------------IHHFWVHTWFDKTHPDIESITGIIRCIDKVPND------- 623
Query: 793 LNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQS 852
P+ VHCSAG GRTG FI +D +L V + ++
Sbjct: 624 --------------------------GPMFVHCSAGVGRTGTFIAVDQILQVPKNILPKT 657
Query: 853 NKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYE 891
++ S D IF VN LR QR+ MVQN Q+ Y+
Sbjct: 658 TNLE---DSKDFIFNCVNSLRSQRMKMVQNFEQFKFLYD 693
>Hs4506313 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1118
Score = 72.4 bits (176), Expect = 3e-12
Identities = 70/269 (26%), Positives = 107/269 (39%), Gaps = 65/269 (24%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
EP +DY NA+++ P + +IATQ PLP T+ DFW +V + ++ L + E
Sbjct: 871 EPGSDYINASFM--PGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEAGR 928
Query: 685 KKWDIYW--NSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQL 742
K + YW +S+ ++VT E+V + N + L
Sbjct: 929 VKCEHYWPLDSQPCTHGHLRVTLVGEEVME---------------------NWTVRELLL 967
Query: 743 PVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLH 802
E + +V Q Y W D G+ P+S D L
Sbjct: 968 LQVEEQKTLSVRQFHYQAWPDH-GV------------------PSS---------PDTLL 999
Query: 803 TYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSA 862
+ ++ +++ G P +VHCSAG GRTG I LD LL L S
Sbjct: 1000 AFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQSEGLLGP--------- 1050
Query: 863 DLIFIVVNELRKQRISMVQNLTQYLTCYE 891
F V ++R+ R MVQ QY+ ++
Sbjct: 1051 ---FSFVRKMRESRPLMVQTEAQYVFLHQ 1076
>Hs4506303 [T] KOG4228 Protein tyrosine phosphatase
Length = 802
Score = 70.1 bits (170), Expect = 1e-11
Identities = 62/278 (22%), Positives = 108/278 (38%), Gaps = 60/278 (21%)
Query: 620 TDYDTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSY 679
T + P +DY NA+++ Q F IA Q P T++DFW ++ +N I+ + +
Sbjct: 285 TPVEGVPDSDYINASFINGYQEKNKF--IAAQGPKEETVNDFWRMIWEQNTATIVMVTNL 342
Query: 680 DELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKF 739
E K YW + + + + EDV + +R + +
Sbjct: 343 KERKECKCAQYWPDQGCWTYG-NIRVSVEDVTVLVDYTVRKFCIQQVGD----------- 390
Query: 740 DQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTED 799
+ N + Q +T W D G+ + +K + +P
Sbjct: 391 ----MTNRKPQRLITQFHFTSWPDF-GVPFTPIGMLKFLKKVKACNP------------- 432
Query: 800 FLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWN 859
++VHCSAG GRTG F+ +D +L ++ + K+DV+
Sbjct: 433 ----------------QYAGAIVVHCSAGVGRTGTFVVIDAMLDMM----HTERKVDVYG 472
Query: 860 MSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEFF 897
V+ +R QR MVQ QY+ Y+++LE +
Sbjct: 473 F--------VSRIRAQRCQMVQTDMQYVFIYQALLEHY 502
Score = 65.5 bits (158), Expect = 4e-10
Identities = 70/274 (25%), Positives = 105/274 (37%), Gaps = 67/274 (24%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
E DY NA+++ +YIA+Q PL TI+DFW ++ I+ L +E
Sbjct: 583 EENTDYVNASFI--DGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQ 640
Query: 685 KKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPV 744
+K YW S + VS D ++ L
Sbjct: 641 EKCAQYWPSDGL--------------------------VSYGDITVE----------LKK 664
Query: 745 KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNL-LLNDPASLFNALNNKTEDFLHT 803
+ E +TV L T ++ +R F H + + + +D + + +
Sbjct: 665 EEECESYTVRDLLVTNTRENKSRQIRQF-HFHGWPEVGIPSDGKGMISII---------- 713
Query: 804 YRKLGLLSVNKNNSGS-PVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSA 862
+ + SG+ P+ VHCSAG GRTG F L +L R +DV
Sbjct: 714 ----AAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVL----ERVKAEGILDV----- 760
Query: 863 DLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
F V LR QR MVQ L QY CY+ + E+
Sbjct: 761 ---FQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 791
>Hs18450369 [T] KOG4228 Protein tyrosine phosphatase
Length = 793
Score = 70.1 bits (170), Expect = 1e-11
Identities = 62/278 (22%), Positives = 108/278 (38%), Gaps = 60/278 (21%)
Query: 620 TDYDTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSY 679
T + P +DY NA+++ Q F IA Q P T++DFW ++ +N I+ + +
Sbjct: 276 TPVEGVPDSDYINASFINGYQEKNKF--IAAQGPKEETVNDFWRMIWEQNTATIVMVTNL 333
Query: 680 DELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKF 739
E K YW + + + + EDV + +R + +
Sbjct: 334 KERKECKCAQYWPDQGCWTYG-NIRVSVEDVTVLVDYTVRKFCIQQVGD----------- 381
Query: 740 DQLPVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTED 799
+ N + Q +T W D G+ + +K + +P
Sbjct: 382 ----MTNRKPQRLITQFHFTSWPDF-GVPFTPIGMLKFLKKVKACNP------------- 423
Query: 800 FLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWN 859
++VHCSAG GRTG F+ +D +L ++ + K+DV+
Sbjct: 424 ----------------QYAGAIVVHCSAGVGRTGTFVVIDAMLDMM----HTERKVDVYG 463
Query: 860 MSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEFF 897
V+ +R QR MVQ QY+ Y+++LE +
Sbjct: 464 F--------VSRIRAQRCQMVQTDMQYVFIYQALLEHY 493
Score = 65.5 bits (158), Expect = 4e-10
Identities = 70/274 (25%), Positives = 105/274 (37%), Gaps = 67/274 (24%)
Query: 625 EPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDM 684
E DY NA+++ +YIA+Q PL TI+DFW ++ I+ L +E
Sbjct: 574 EENTDYVNASFI--DGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQ 631
Query: 685 KKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPV 744
+K YW S + VS D ++ L
Sbjct: 632 EKCAQYWPSDGL--------------------------VSYGDITVE----------LKK 655
Query: 745 KNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNL-LLNDPASLFNALNNKTEDFLHT 803
+ E +TV L T ++ +R F H + + + +D + + +
Sbjct: 656 EEECESYTVRDLLVTNTRENKSRQIRQF-HFHGWPEVGIPSDGKGMISII---------- 704
Query: 804 YRKLGLLSVNKNNSGS-PVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSA 862
+ + SG+ P+ VHCSAG GRTG F L +L R +DV
Sbjct: 705 ----AAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVL----ERVKAEGILDV----- 751
Query: 863 DLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
F V LR QR MVQ L QY CY+ + E+
Sbjct: 752 ---FQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY 782
>7298436 [T] KOG4228 Protein tyrosine phosphatase
Length = 715
Score = 67.8 bits (164), Expect = 7e-11
Identities = 67/280 (23%), Positives = 119/280 (41%), Gaps = 66/280 (23%)
Query: 628 NDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKW 687
+DY NA+Y+ + P+ YI TQ P+ T+ +W +V +N+ I+ L +
Sbjct: 186 SDYVNASYVD-SLLKPNA-YIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMC 243
Query: 688 DIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNE 747
YW ++V Y D+F +N+ + + Q N + +L NE
Sbjct: 244 HQYWPPN------MEVHEQYGDIF---------INIVREE---QLANFHIRTFRLYKMNE 285
Query: 748 SRPHT----VYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHT 803
+ T + Q YT+W + H N LL + + N +D
Sbjct: 286 KQEVTDERLILQFHYTEW----------YSHSCPFSNALLEFRRRVRLVVGNIIKD---- 331
Query: 804 YRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSAD 863
+++ P+LVHCS G GR+GV++++D L + + + +N
Sbjct: 332 ----------EDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEE-------ECFN---- 370
Query: 864 LIFIVVNELRKQRISMVQNLTQYLTCYESMLEFFYLKEHI 903
+F + +LR+ R +V+N+ QY Y++ L+EHI
Sbjct: 371 -VFGYLKKLRQSRKGLVENVEQYKFIYDT------LEEHI 403
>Hs19743929 [T] KOG4228 Protein tyrosine phosphatase
Length = 1444
Score = 63.9 bits (154), Expect = 1e-09
Identities = 75/278 (26%), Positives = 117/278 (41%), Gaps = 75/278 (26%)
Query: 623 DTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDEL 682
D +P +DY NANY+ + +YIATQ P+ T+ DF
Sbjct: 938 DGDPHSDYINANYI--DGYHRPRHYIATQGPMQETVKDF--------------------- 974
Query: 683 DMKKWDIYW--NSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVS--KSDSRIQSPNKRTK 738
W + W NS SI V VTN E + RV V D+ + K T
Sbjct: 975 ----WRMIWQENSASI----VMVTNLVE--------VGRVKCVRYWPDDTEVYGDIKVTL 1018
Query: 739 FDQLPVKNES-RPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKT 797
+ P+ R TV + Y + + + ++H + + L
Sbjct: 1019 IETEPLAEYVIRTFTVQKKGYHEIRE---------LRLFHFTSWPDHGVPCYATGL---- 1065
Query: 798 EDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDV 857
L R++ L N +G P++VHCSAG GRTG FI +D +L + ++ +D+
Sbjct: 1066 ---LGFVRQVKFL--NPPEAG-PIVVHCSAGAGRTGCFIAIDTMLDMAEN----EGVVDI 1115
Query: 858 WNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
+N V ELR QR+++VQ QY+ ++++LE
Sbjct: 1116 FN--------CVRELRAQRVNLVQTEEQYVFVHDAILE 1145
>Hs19743927 [T] KOG4228 Protein tyrosine phosphatase
Length = 1463
Score = 63.9 bits (154), Expect = 1e-09
Identities = 75/278 (26%), Positives = 117/278 (41%), Gaps = 75/278 (26%)
Query: 623 DTEPFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDEL 682
D +P +DY NANY+ + +YIATQ P+ T+ DF
Sbjct: 957 DGDPHSDYINANYI--DGYHRPRHYIATQGPMQETVKDF--------------------- 993
Query: 683 DMKKWDIYW--NSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVS--KSDSRIQSPNKRTK 738
W + W NS SI V VTN E + RV V D+ + K T
Sbjct: 994 ----WRMIWQENSASI----VMVTNLVE--------VGRVKCVRYWPDDTEVYGDIKVTL 1037
Query: 739 FDQLPVKNES-RPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKT 797
+ P+ R TV + Y + + + ++H + + L
Sbjct: 1038 IETEPLAEYVIRTFTVQKKGYHEIRE---------LRLFHFTSWPDHGVPCYATGL---- 1084
Query: 798 EDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDV 857
L R++ L N +G P++VHCSAG GRTG FI +D +L + ++ +D+
Sbjct: 1085 ---LGFVRQVKFL--NPPEAG-PIVVHCSAGAGRTGCFIAIDTMLDMAEN----EGVVDI 1134
Query: 858 WNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLE 895
+N V ELR QR+++VQ QY+ ++++LE
Sbjct: 1135 FN--------CVRELRAQRVNLVQTEEQYVFVHDAILE 1164
>CE20702 [T] KOG0789 Protein tyrosine phosphatase
Length = 446
Score = 59.7 bits (143), Expect = 2e-08
Identities = 56/265 (21%), Positives = 106/265 (39%), Gaps = 66/265 (24%)
Query: 626 PFNDYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMK 685
P ND+ +AN++ +P F YI+ Q P+ T++DFW++V ++ ++ + ++E ++
Sbjct: 166 PDNDFIHANWMTMPD---KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQ 222
Query: 686 KWDIYWNSKSIRKHE---VKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQL 742
K Y S+ H ++T + L+ +S +D ++ P+ L
Sbjct: 223 KCSRYIPSEDNISHVCGIYRITKIDQMTMVYADVALQSFEISVTDKSLECPS-------L 275
Query: 743 PVKNESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLH 802
VK+ + KW D H + L AL +
Sbjct: 276 VVKH---------YHFLKWRD-------------HTAPMTSISVLKLLKALRDPKRP--- 310
Query: 803 TYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSA 862
P ++HCSAG GRT I +D+ + R + +++V +
Sbjct: 311 ----------------GPPVIHCSAGIGRTATLIGVDY----GNQRIGEVGEMNVLD--- 347
Query: 863 DLIFIVVNELRKQRISMVQNLTQYL 887
+V E+R+ R VQ+ Q++
Sbjct: 348 -----IVREMRQMRDKAVQSHHQFI 367
>CE05815 [T] KOG0789 Protein tyrosine phosphatase
Length = 597
Score = 58.2 bits (139), Expect = 6e-08
Identities = 68/269 (25%), Positives = 107/269 (39%), Gaps = 71/269 (26%)
Query: 629 DYFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWD 688
DY +ANY++ P F I TQ PL T D W +VL + + I L E K +
Sbjct: 233 DYVHANYVK--GTKPMF--ILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCE 288
Query: 689 IYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPV--KN 746
Y+ D G +L ++ + + +P+ T+ L V K
Sbjct: 289 PYFP-------------------DTEGQVLTFGEITVTCTESTTPDNHTQLKMLTVMDKK 329
Query: 747 ESRPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNALNNKTEDFLHTYRK 806
+ H +Y + W D K++ L++ A L T R
Sbjct: 330 SGKSHKLYHYKIITWPD---------------KSIALSNLA------------ILRTLRS 362
Query: 807 LGLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIF 866
L + P++VHCSAG GRTG F ++ +G + ++ + ADL
Sbjct: 363 LRKMP-------GPIVVHCSAGIGRTGTFAAIE--VGAQCLLNGKAFR------PADL-- 405
Query: 867 IVVNELRKQRISMVQNLTQYLTCYESMLE 895
V +R R++ VQ TQYL E++L+
Sbjct: 406 --VRAVRHCRLNSVQMDTQYLMLVEAILD 432
>7290546 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1767
Score = 57.0 bits (136), Expect = 1e-07
Identities = 32/84 (38%), Positives = 49/84 (58%), Gaps = 12/84 (14%)
Query: 820 PVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISM 879
P++VHCSAG GR+G FI LD +L ++S+ +D IF +V +RK+R+ M
Sbjct: 1520 PIIVHCSAGVGRSGTFIALDRIL----QHIHKSDYVD--------IFGIVFAMRKERVFM 1567
Query: 880 VQNLTQYLTCYESMLEFFYLKEHI 903
VQ QY+ ++ +L KEH+
Sbjct: 1568 VQTEQQYVCIHQCLLAVLEGKEHL 1591
Score = 53.1 bits (126), Expect = 2e-06
Identities = 32/94 (34%), Positives = 43/94 (45%), Gaps = 12/94 (12%)
Query: 608 PANRSETTATSETDYDTEPF----------NDYFNANYLRLPQINPDFNYIATQAPLPST 657
P NR + T+ YD F +DY NANY+ P N +I TQ PL ST
Sbjct: 1351 PCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYM--PGHNSPREFIVTQGPLHST 1408
Query: 658 IDDFWNVVLSKNLKVIISLNSYDELDMKKWDIYW 691
++FW + N + I+ L E +K D YW
Sbjct: 1409 REEFWRMCWESNSRAIVMLTRCFEKGREKCDQYW 1442
>CE09339 [T] KOG0789 Protein tyrosine phosphatase
Length = 395
Score = 56.6 bits (135), Expect = 2e-07
Identities = 60/277 (21%), Positives = 111/277 (39%), Gaps = 43/277 (15%)
Query: 630 YFNANYLRLPQINPDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLNSYDELDMKKWDI 689
Y NA+ P+I +YI T A + I FW +V + I+ L EL ++K D
Sbjct: 85 YINASVAEFPEIGR--HYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDK 142
Query: 690 YWNSKSIRKHEVKVTN-TYEDVFDIPGCILRVMNVSKSDSRIQSPNKRTKFDQLPVKNES 748
Y+ + + + + + + T ++ R++ V+ + Q P S
Sbjct: 143 YFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVAMNIFSFQKP--------------S 188
Query: 749 RPHTVYQLQYTKWLDSCGINMRDFIHIYHIKNLLLNDPASLFNAL-NNKTEDFLHTYRKL 807
H V+ ++ W + DF+ Y N + L + NN F Y
Sbjct: 189 ETHQVHHYKFHGWTEFNLPKYEDFMAFY---NTMKEVGVPLLAVMKNNCMSSFFKKYH-- 243
Query: 808 GLLSVNKNNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQSNKIDVW--------- 858
+ + +P+ + CS G R GVFI +D L+ ++D+R S I+ W
Sbjct: 244 -----HTPPTNAPI-IQCSTGGARCGVFIIIDILINLIDNRIKNSYSIEWWMLKVRSKRN 297
Query: 859 -----NMSADLIFIVVNELRKQRISMVQNLTQYLTCY 890
N I+ ++ + + R + +++L +YL +
Sbjct: 298 HSALTNQQHSFIYDIIIKYIRTRHNQLRHLEKYLEAH 334
>7297098 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 1252
Score = 52.4 bits (124), Expect = 3e-06
Identities = 64/284 (22%), Positives = 112/284 (38%), Gaps = 91/284 (32%)
Query: 630 YFNANYLRLPQINPDFNYIATQAPL-PSTIDDFWNVVLSKNLKVIISL---------NSY 679
Y NA+ + YI Q+P P T+ FW V ++ +++ L NS+
Sbjct: 1036 YVNASSISATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMSYIPRNSH 1095
Query: 680 DELDMKKWDIY--WNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRT 737
L+ ++ +Y ++ + R +K LR+ +V P++R
Sbjct: 1096 QRLEFGQFQVYQEFSQTTDRCTTIK---------------LRLYHV---------PSRRY 1131
Query: 738 KFDQLPVKNESRPHTVYQLQYTKWLD-SCGINMRDFIHIYHIKNLLLNDPASLFNALNNK 796
+ +V+ LQY W + +C ++ F+
Sbjct: 1132 R-------------SVWYLQYADWAEQNCPRDVNHFL----------------------- 1155
Query: 797 TEDFLHTYRKLGLLSVNK----NNSGSPVLVHCSAGCGRTGVFITLDFLLGVLDSRSNQS 852
DFL + L S + +N+ PVL+HC G GR+GV +T D LL LD +
Sbjct: 1156 --DFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLD----HN 1209
Query: 853 NKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEF 896
+D+ V+ +LR QR S++ +L QY Y ++ +
Sbjct: 1210 EDLDIPR--------VIGQLRHQRDSIIPSLAQYKFIYNLLITY 1245
>Hs18375644 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 460
Score = 52.0 bits (123), Expect = 4e-06
Identities = 41/146 (28%), Positives = 63/146 (43%), Gaps = 26/146 (17%)
Query: 625 EPFNDYFNANYLRLPQIN-------PDFNYIATQAPLPSTIDDFWNVVLSKNLKVIISLN 677
EP +DY NAN + +P+ P +YIATQ L +T++DFW +V +N +VI+
Sbjct: 299 EPVSDYINANII-MPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTT 357
Query: 678 SYDELDMKKWDIYWNSKSIRKHEVKVTNTYEDVFDIPGCILRVMNVSKSDSRIQSPNKRT 737
E K YW + K ++RV NV +S + +
Sbjct: 358 KEVERGKSKCVKYWPDEYALKEY---------------GVMRVRNVKESAAH-DYTLREL 401
Query: 738 KFDQLPVKNESRPHTVYQLQYTKWLD 763
K ++ N R TV+Q + W D
Sbjct: 402 KLSKVGQGNTER--TVWQYHFRTWPD 425
>CE28359 [T] KOG0789 Protein tyrosine phosphatase
Length = 456
Score = 51.6 bits (122), Expect = 5e-06
Identities = 58/246 (23%), Positives = 100/246 (40%), Gaps = 62/246 (25%)
Query: 662 WNVVLSKNLKVIISLNSYDELDMKKWDIYWNSKSIRKH---EVKVTNTYEDVFDIPGCIL 718
W ++ + +++ L EL+ K + YW + + ++T E +FD ++
Sbjct: 172 WKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITLEEEKLFDDDEYLM 231
Query: 719 RVMNVSKSDSRIQSPNKRTKFDQLPVKNESRPHTVYQLQYTKWLD-SCGINMRDFIHIYH 777
R + + + E R V+QL Y +W D C + ++
Sbjct: 232 RCLKMENQTT-----------------GECRK--VHQLHYREWPDHGCPSGEKQLLN--- 269
Query: 778 IKNLLLNDPASLFNALNNKTEDFLHTYRKLGLLSVNKNNSGSPVLVHCSAGCGRTGVFIT 837
+ + + N E+ V+ +S SP+LVHCSAG GRTG I
Sbjct: 270 -----------MIDLMENIHEE------------VSPQDS-SPILVHCSAGVGRTGTIIA 305
Query: 838 LDFLLGVLDSRSNQSNKIDVWNMSADLIFIVVNELRKQRISMVQNLTQYLTCYESMLEFF 897
++F+ + + + S ID IF +V LRKQR SMVQ Q+ + +
Sbjct: 306 INFIREQMKAETLHS--ID--------IFGLVMTLRKQRASMVQTQDQFQFVHRCIAS-- 353
Query: 898 YLKEHI 903
Y + H+
Sbjct: 354 YCRRHL 359
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.133 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,872,657
Number of Sequences: 60738
Number of extensions: 2421149
Number of successful extensions: 7430
Number of sequences better than 1.0e-05: 85
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 7024
Number of HSP's gapped (non-prelim): 335
length of query: 903
length of database: 30,389,216
effective HSP length: 115
effective length of query: 788
effective length of database: 23,404,346
effective search space: 18442624648
effective search space used: 18442624648
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)