ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV1811 check: MH T KOG0581 Signal transduction mechanisms Mitogen-activated protein kinase kinase (MAP2K)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV1811 623352 624746 465
(465 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 475 e-134
YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 464 e-130
SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (... 309 7e-84
Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (... 196 8e-50
7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 194 2e-49
Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 187 2e-47
Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 187 2e-47
Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (... 187 2e-47
SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (... 186 5e-47
Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (... 186 8e-47
Hs21729899 [T] KOG0581 Mitogen-activated protein kinase kinase (... 179 1e-44
CE25437 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 174 3e-43
YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 169 1e-41
Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 168 1e-41
Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 167 3e-41
At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 163 6e-40
YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 162 1e-39
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 161 2e-39
Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST 161 2e-39
Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST 161 2e-39
CE28674 [T] KOG0201 Serine/threonine protein kinase 161 2e-39
CE07510 [T] KOG0201 Serine/threonine protein kinase 161 2e-39
7292830 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 161 2e-39
At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 160 4e-39
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 159 6e-39
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 159 6e-39
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 159 6e-39
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 159 6e-39
7300224 [T] KOG0201 Serine/threonine protein kinase 159 6e-39
Hs15011880 [T] KOG0201 Serine/threonine protein kinase 159 1e-38
CE07399 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 159 1e-38
Hs4506889 [T] KOG1006 Mitogen-activated protein kinase (MAPK) ki... 157 2e-38
HsM5454174 [T] KOG0201 Serine/threonine protein kinase 156 5e-38
Hs21361358 [T] KOG0201 Serine/threonine protein kinase 156 5e-38
7299057 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 156 7e-38
SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase ... 154 3e-37
7302458 [T] KOG0574 STE20-like serine/threonine kinase MST 154 4e-37
At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 153 5e-37
Hs21618351 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 153 6e-37
At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 153 6e-37
CE24941 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 152 1e-36
Hs20070158 [T] KOG0201 Serine/threonine protein kinase 151 2e-36
At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 151 2e-36
Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 151 2e-36
HsM4506099 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 150 4e-36
Hs21618349 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 150 4e-36
Hs21618347 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 150 4e-36
Hs21735542 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 149 7e-36
At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 147 3e-35
CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 146 7e-35
CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 146 7e-35
CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 146 7e-35
At3g15220 [T] KOG0201 Serine/threonine protein kinase 145 1e-34
At1g53165 [T] KOG0201 Serine/threonine protein kinase 145 2e-34
Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 141 2e-33
At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 140 4e-33
7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 140 4e-33
Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase k... 140 5e-33
SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase 139 7e-33
7292829 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 139 7e-33
SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase 139 1e-32
Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase 138 2e-32
Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 138 2e-32
HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 137 4e-32
Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 137 4e-32
Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 137 4e-32
Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 137 4e-32
YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase 134 2e-31
Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase 134 2e-31
Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase 134 2e-31
CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase 134 2e-31
Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase k... 134 3e-31
7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase 134 4e-31
HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase k... 133 6e-31
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 132 1e-30
YHR102w [T] KOG0201 Serine/threonine protein kinase 132 1e-30
CE10328 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 131 2e-30
7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 131 2e-30
Hs4507275 [D] KOG0580 Serine/threonine protein kinase 130 4e-30
HsM4507279 [D] KOG0580 Serine/threonine protein kinase 129 7e-30
Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase k... 129 7e-30
At3g06230 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 129 9e-30
At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 129 1e-29
At1g53570 [T] KOG0198 MEKK and related serine/threonine protein ... 129 1e-29
Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 129 1e-29
CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 128 2e-29
At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 128 2e-29
Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase 128 2e-29
Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and re... 127 3e-29
Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 127 3e-29
CE04724 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 126 6e-29
YDR523c [T] KOG0201 Serine/threonine protein kinase 125 1e-28
SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein ... 125 1e-28
Hs19923464 [T] KOG0577 Serine/threonine protein kinase 125 1e-28
CE29622 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 125 2e-28
7299536 [D] KOG0580 Serine/threonine protein kinase 124 2e-28
CE16527 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 124 3e-28
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 124 4e-28
Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase 123 5e-28
Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase 122 9e-28
Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 122 9e-28
At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase 122 1e-27
At2g45490 [D] KOG0580 Serine/threonine protein kinase 122 1e-27
Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase 121 3e-27
SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein... 120 6e-27
Hs7706401 [T] KOG0577 Serine/threonine protein kinase 119 7e-27
Hs4759208 [T] KOG0577 Serine/threonine protein kinase 119 7e-27
Hs14771959 [T] KOG0578 p21-activated serine/threonine protein ki... 119 7e-27
7293601 [T] KOG0577 Serine/threonine protein kinase 119 1e-26
Hs5174547 [T] KOG4279 Serine/threonine protein kinase 118 2e-26
7300559 [T] KOG4279 Serine/threonine protein kinase 118 2e-26
CE21025 [D] KOG0580 Serine/threonine protein kinase 118 2e-26
At3g07980 [T] KOG0198 MEKK and related serine/threonine protein ... 118 2e-26
Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase 117 3e-26
CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase 117 3e-26
At3g13530 [T] KOG0198 MEKK and related serine/threonine protein ... 117 3e-26
7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 117 3e-26
At1g09000 [T] KOG0198 MEKK and related serine/threonine protein ... 117 4e-26
7298926 [T] KOG0578 p21-activated serine/threonine protein kinase 117 4e-26
Hs4507273 [D] KOG0580 Serine/threonine protein kinase 116 6e-26
At5g55090 [T] KOG0198 MEKK and related serine/threonine protein ... 116 8e-26
7293496 [R] KOG0597 Serine-threonine protein kinase FUSED 116 8e-26
ECU07g0360 [D] KOG0580 Serine/threonine protein kinase 115 2e-25
CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase 115 2e-25
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 114 3e-25
Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase 114 4e-25
At4g26890 [T] KOG0198 MEKK and related serine/threonine protein ... 114 4e-25
7302861 [T] KOG0696 Serine/threonine protein kinase 114 4e-25
Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine prote... 114 4e-25
CE04493 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 113 5e-25
YAR019c [T] KOG0198 MEKK and related serine/threonine protein ki... 113 7e-25
At2g25880 [D] KOG0580 Serine/threonine protein kinase 113 7e-25
At3g06030 [T] KOG0198 MEKK and related serine/threonine protein ... 112 9e-25
Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 112 1e-24
CE27177 [T] KOG4279 Serine/threonine protein kinase 112 1e-24
At2g32510 [T] KOG0198 MEKK and related serine/threonine protein ... 112 1e-24
At1g63700 [T] KOG0198 MEKK and related serine/threonine protein ... 112 2e-24
YPL150w [T] KOG0583 Serine/threonine protein kinase 110 3e-24
At4g32830 [D] KOG0580 Serine/threonine protein kinase 110 3e-24
At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase 110 3e-24
Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE 110 4e-24
CE01405 [T] KOG0577 Serine/threonine protein kinase 110 4e-24
At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase 110 6e-24
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 110 6e-24
7300149 [T] KOG0578 p21-activated serine/threonine protein kinase 109 8e-24
SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase 108 1e-23
Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein ... 108 1e-23
CE21239 [T] KOG0583 Serine/threonine protein kinase 108 1e-23
At1g54960 [T] KOG0198 MEKK and related serine/threonine protein ... 108 1e-23
At1g32320 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 108 1e-23
YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase 108 2e-23
Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 108 2e-23
CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase 108 2e-23
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 108 2e-23
YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 107 3e-23
CE24761 [D] KOG0580 Serine/threonine protein kinase 107 3e-23
At4g08500 [T] KOG0198 MEKK and related serine/threonine protein ... 107 3e-23
CE29092 [T] KOG0694 Serine/threonine protein kinase 107 4e-23
CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase 107 4e-23
CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase 107 4e-23
YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 107 5e-23
Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 107 5e-23
Hs16950621 [Z] KOG0613 Projectin/twitchin and related proteins 107 5e-23
Hs16950613 [Z] KOG0613 Projectin/twitchin and related proteins 107 5e-23
Hs16950611 [Z] KOG0613 Projectin/twitchin and related proteins 107 5e-23
Hs16950601 [Z] KOG0613 Projectin/twitchin and related proteins 107 5e-23
At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 107 5e-23
YHR205w [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 106 6e-23
Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE 106 6e-23
Hs22065797 [T] KOG0577 Serine/threonine protein kinase 106 6e-23
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 106 8e-23
CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 105 1e-22
At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GT... 105 1e-22
7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 105 1e-22
Hs20070247_2 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 105 1e-22
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 105 1e-22
At5g66850 [T] KOG0198 MEKK and related serine/threonine protein ... 105 1e-22
At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase 105 1e-22
7297776 [D] KOG0580 Serine/threonine protein kinase 105 1e-22
YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 105 2e-22
Hs4759178 [D] KOG0580 Serine/threonine protein kinase 105 2e-22
CE12518 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 105 2e-22
CE23001 [R] KOG0589 Serine/threonine protein kinase 104 2e-22
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 104 2e-22
YLR362w [T] KOG0198 MEKK and related serine/threonine protein ki... 104 3e-22
HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein... 104 3e-22
CE17354 [T] KOG0694 Serine/threonine protein kinase 104 3e-22
CE17353 [T] KOG0694 Serine/threonine protein kinase 104 3e-22
At1g12680 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 104 3e-22
7303111 [T] KOG0695 Serine/threonine protein kinase 104 3e-22
SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase 103 4e-22
Hs20535816 [T] KOG0695 Serine/threonine protein kinase 103 4e-22
Hs10864650 [T] KOG0695 Serine/threonine protein kinase 103 4e-22
At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 103 4e-22
YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 103 5e-22
SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 103 5e-22
Hs14916455 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 103 7e-22
At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase 103 7e-22
Hs4758702 [T] KOG4279 Serine/threonine protein kinase 102 9e-22
Hs4506071 [T] KOG0695 Serine/threonine protein kinase 102 9e-22
CE03232 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 102 9e-22
YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 102 1e-21
Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE 102 1e-21
Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein... 102 1e-21
Hs20547878 [R] KOG0589 Serine/threonine protein kinase 102 2e-21
7302860 [T] KOG0696 Serine/threonine protein kinase 102 2e-21
7302464 [R] KOG0586 Serine/threonine protein kinase 102 2e-21
YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase 101 3e-21
SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related... 101 3e-21
At1g05100 [T] KOG0198 MEKK and related serine/threonine protein ... 101 3e-21
Hs4826948 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 100 4e-21
CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 100 4e-21
CE15475 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 100 4e-21
CE15473 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 100 4e-21
CE02586 [T] KOG0696 Serine/threonine protein kinase 100 4e-21
SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protei... 100 5e-21
At4g08480 [T] KOG0198 MEKK and related serine/threonine protein ... 100 5e-21
At4g08470 [T] KOG0198 MEKK and related serine/threonine protein ... 100 5e-21
At2g46700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 5e-21
YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases 100 8e-21
Hs13899225 [R] KOG0586 Serine/threonine protein kinase 100 8e-21
Hs10835065 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 100 8e-21
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 99 1e-20
Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neuro... 99 1e-20
CE27768 [R] KOG0586 Serine/threonine protein kinase 99 1e-20
CE23838 [R] KOG0586 Serine/threonine protein kinase 99 1e-20
At1g54510 [R] KOG0589 Serine/threonine protein kinase 99 1e-20
SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protei... 99 1e-20
Hs14776113 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 99 1e-20
Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase 99 1e-20
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 99 2e-20
HsM4505191 [T] KOG0607 MAP kinase-interacting kinase and related... 99 2e-20
Hs7661974 [T] KOG0583 Serine/threonine protein kinase 99 2e-20
At3g20860 [R] KOG0589 Serine/threonine protein kinase 99 2e-20
7304283 [Z] KOG0613 Projectin/twitchin and related proteins 99 2e-20
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 99 2e-20
Hs6912584 [R] KOG0594 Protein kinase PCTAIRE and related kinases 98 2e-20
Hs4506067 [T] KOG0696 Serine/threonine protein kinase 98 2e-20
Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 98 2e-20
CE28218 [D] KOG0588 Serine/threonine protein kinase 98 2e-20
At3g56760 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 98 2e-20
At2g41140 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 98 2e-20
7299322 [R] KOG0611 Predicted serine/threonine protein kinase 98 2e-20
Hs4758192 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 98 3e-20
Hs4506785 [T] KOG0660 Mitogen-activated protein kinase 98 3e-20
Hs4506055 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 98 3e-20
At1g49580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 98 3e-20
YPL209c [D] KOG0580 Serine/threonine protein kinase 97 4e-20
Hs14735945 [T] KOG0694 Serine/threonine protein kinase 97 4e-20
CE06635 [Z] KOG0613 Projectin/twitchin and related proteins 97 4e-20
CE06634 [Z] KOG0613 Projectin/twitchin and related proteins 97 4e-20
At5g39440 [T] KOG0583 Serine/threonine protein kinase 97 4e-20
At4g24400 [T] KOG0583 Serine/threonine protein kinase 97 4e-20
At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 4e-20
At1g29230 [T] KOG0583 Serine/threonine protein kinase 97 4e-20
CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase 97 4e-20
YDR122w [T] KOG0583 Serine/threonine protein kinase 97 5e-20
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 97 5e-20
CE03979 [T] KOG0614 cGMP-dependent protein kinase 97 5e-20
SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 97 7e-20
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 97 7e-20
Hs4885349 [T] KOG0986 G protein-coupled receptor kinase 97 7e-20
Hs4885055 [T] KOG0986 G protein-coupled receptor kinase 97 7e-20
Hs16950619 [Z] KOG0613 Projectin/twitchin and related proteins 97 7e-20
CE23702 [T] KOG4721 Serine/threonine protein kinase contains leu... 97 7e-20
At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 7e-20
7296166 [T] KOG0614 cGMP-dependent protein kinase 97 7e-20
7290147 [T] KOG0583 Serine/threonine protein kinase 97 7e-20
SPCC24B10.07 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 96 9e-20
Hs5453964 [T] KOG0583 Serine/threonine protein kinase 96 9e-20
Hs4504101 [T] KOG0986 G protein-coupled receptor kinase 96 9e-20
Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 96 9e-20
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 96 9e-20
ECU11g1500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 96 9e-20
CE15235 [R] KOG0589 Serine/threonine protein kinase 96 9e-20
At1g67580 [R] KOG0663 Protein kinase PITSLRE and related kinases 96 9e-20
7301734 [T] KOG0694 Serine/threonine protein kinase 96 9e-20
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 96 1e-19
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 96 1e-19
Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains l... 96 1e-19
Hs10835242 [T] KOG0614 cGMP-dependent protein kinase 96 1e-19
CE01554 [T] KOG0986 G protein-coupled receptor kinase 96 1e-19
SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases 96 1e-19
Hs4506073 [T] KOG0694 Serine/threonine protein kinase 96 1e-19
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 96 1e-19
Hs14758219 [T] KOG0694 Serine/threonine protein kinase 96 1e-19
Hs13384594 [T] KOG0696 Serine/threonine protein kinase 96 1e-19
CE20167 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 96 1e-19
At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 1e-19
SPAC22E12.14c [RT] KOG0598 Ribosomal protein S6 kinase and relat... 95 2e-19
SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-speci... 95 2e-19
Hs9845489 [R] KOG0586 Serine/threonine protein kinase 95 2e-19
Hs9845487 [R] KOG0586 Serine/threonine protein kinase 95 2e-19
Hs5453976 [T] KOG0694 Serine/threonine protein kinase 95 2e-19
Hs5453970 [T] KOG0694 Serine/threonine protein kinase 95 2e-19
Hs5032091 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 95 2e-19
Hs4885549 [T] KOG0690 Serine/threonine protein kinase 95 2e-19
Hs22062450 [R] KOG0586 Serine/threonine protein kinase 95 2e-19
Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 95 2e-19
Hs15619015 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 95 2e-19
Hs5453972 [T] KOG0694 Serine/threonine protein kinase 95 3e-19
At5g28290 [R] KOG0589 Serine/threonine protein kinase 95 3e-19
At3g04810 [R] KOG0589 Serine/threonine protein kinase 95 3e-19
Hs8923922 [R] KOG0586 Serine/threonine protein kinase 94 3e-19
Hs5453860 [R] KOG0594 Protein kinase PCTAIRE and related kinases 94 3e-19
Hs4885563 [T] KOG0694 Serine/threonine protein kinase 94 3e-19
Hs4506057 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 94 3e-19
Hs22068916 [T] KOG0696 Serine/threonine protein kinase 94 3e-19
Hs20127450 [T] KOG0696 Serine/threonine protein kinase 94 3e-19
Hs18602554 [T] KOG0578 p21-activated serine/threonine protein ki... 94 3e-19
Hs15011928 [R] KOG0594 Protein kinase PCTAIRE and related kinases 94 3e-19
ECU03g0980 [T] KOG0583 Serine/threonine protein kinase 94 3e-19
CE22045 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 94 3e-19
CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 94 3e-19
At4g04700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 94 3e-19
7303915 [T] KOG0694 Serine/threonine protein kinase 94 3e-19
7303914 [T] KOG0694 Serine/threonine protein kinase 94 3e-19
Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase 94 4e-19
At5g35410 [T] KOG0583 Serine/threonine protein kinase 94 4e-19
At5g04510 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 94 4e-19
At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 94 4e-19
YLR096w [T] KOG0583 Serine/threonine protein kinase 94 6e-19
Hs8923754 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 94 6e-19
Hs4826675 [UT] KOG0662 Cyclin-dependent kinase CDK5 94 6e-19
At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protei... 94 6e-19
ECU08g1790 [D] KOG0600 Cdc2-related protein kinase 93 7e-19
At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 93 7e-19
At2g26980 [T] KOG0583 Serine/threonine protein kinase 93 7e-19
At1g45160 [TR] KOG0606 Microtubule-associated serine/threonine k... 93 7e-19
At1g23700 [T] KOG0582 Ste20-like serine/threonine protein kinase 93 7e-19
YMR104c [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 93 1e-18
YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase 93 1e-18
YBL105c [T] KOG0694 Serine/threonine protein kinase 93 1e-18
Hs9994197 [T] KOG0607 MAP kinase-interacting kinase and related ... 93 1e-18
Hs5453978 [T] KOG0614 cGMP-dependent protein kinase 93 1e-18
Hs5453974 [T] KOG0694 Serine/threonine protein kinase 93 1e-18
Hs4505649 [R] KOG0594 Protein kinase PCTAIRE and related kinases 93 1e-18
Hs16160923 [R] KOG0594 Protein kinase PCTAIRE and related kinases 93 1e-18
CE29331 [T] KOG0194 Protein tyrosine kinase 93 1e-18
CE04494 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 93 1e-18
At4g38470 [T] KOG0192 Tyrosine kinase specific for activated (GT... 93 1e-18
At3g45240 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase k... 93 1e-18
At2g30360 [T] KOG0583 Serine/threonine protein kinase 93 1e-18
7295426 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 93 1e-18
Hs4826684_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 93 1e-18
SPAC890.03 [T] KOG0583 Serine/threonine protein kinase 92 1e-18
Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PK... 92 1e-18
CE28918 [R] KOG0594 Protein kinase PCTAIRE and related kinases 92 1e-18
CE27573 [T] KOG0198 MEKK and related serine/threonine protein ki... 92 1e-18
CE19898 [T] KOG0614 cGMP-dependent protein kinase 92 1e-18
CE19897 [T] KOG0614 cGMP-dependent protein kinase 92 1e-18
CE18608 [R] KOG0594 Protein kinase PCTAIRE and related kinases 92 1e-18
CE15612 [T] KOG0690 Serine/threonine protein kinase 92 1e-18
CE07737 [T] KOG0198 MEKK and related serine/threonine protein ki... 92 1e-18
CE05507 [T] KOG0603 Ribosomal protein S6 kinase 92 1e-18
CE02604 [T] KOG0695 Serine/threonine protein kinase 92 1e-18
At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 92 1e-18
7295638 [T] KOG0603 Ribosomal protein S6 kinase 92 1e-18
7293761 [T] KOG4721 Serine/threonine protein kinase contains leu... 92 1e-18
YKL101w [D] KOG0588 Serine/threonine protein kinase 92 2e-18
SPBC12D12.04c [T] KOG0694 Serine/threonine protein kinase 92 2e-18
Hs4557439 [R] KOG0594 Protein kinase PCTAIRE and related kinases 92 2e-18
Hs4506737 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 92 2e-18
CE18699 [T] KOG0694 Serine/threonine protein kinase 92 2e-18
At5g45820 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
7302050 [T] KOG0986 G protein-coupled receptor kinase 92 2e-18
YCR091w [R] KOG0610 Putative serine/threonine protein kinase 92 2e-18
YBR160w [R] KOG0594 Protein kinase PCTAIRE and related kinases 92 2e-18
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 92 2e-18
Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 2e-18
Hs4506739 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 92 2e-18
CE28643 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
CE07458 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
CE02074 [T] KOG0986 G protein-coupled receptor kinase 92 2e-18
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 92 2e-18
At3g10540 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 92 2e-18
At1g61950 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 2e-18
At1g30270 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
7303211 [T] KOG4717 Serine/threonine protein kinase 92 2e-18
7294265 [TR] KOG0606 Microtubule-associated serine/threonine kin... 92 2e-18
YNR047w [R] KOG0610 Putative serine/threonine protein kinase 91 3e-18
Hs4506103 [J] KOG1033 eIF-2alpha kinase PEK/EIF2AK3 91 3e-18
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 91 3e-18
CE20258 [R] KOG0593 Predicted protein kinase KKIAMRE 91 3e-18
CE05274 [T] KOG0690 Serine/threonine protein kinase 91 3e-18
7300773 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase... 91 3e-18
7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 91 3e-18
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 91 3e-18
Hs4758194 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 91 4e-18
Hs4506529 [T] KOG0986 G protein-coupled receptor kinase 91 4e-18
CE20493 [TR] KOG0606 Microtubule-associated serine/threonine kin... 91 4e-18
CE08385 [T] KOG0194 Protein tyrosine kinase 91 4e-18
At5g60550 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase k... 91 4e-18
At2g41930 [T] KOG0198 MEKK and related serine/threonine protein ... 91 4e-18
7304311 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 91 4e-18
7301971 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 91 4e-18
7298087 [T] KOG0660 Mitogen-activated protein kinase 91 4e-18
Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE 91 5e-18
Hs22057171 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 91 5e-18
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 91 5e-18
CE20716 [T] KOG0194 Protein tyrosine kinase 91 5e-18
At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 91 5e-18
7297009 [R] KOG0593 Predicted protein kinase KKIAMRE 91 5e-18
7290150 [T] KOG0583 Serine/threonine protein kinase 91 5e-18
Hs6005922_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 91 5e-18
CE27894_1 [R] KOG0589 Serine/threonine protein kinase 91 5e-18
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 90 6e-18
Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase 90 6e-18
CE27902 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 90 6e-18
At5g25110 [T] KOG0583 Serine/threonine protein kinase 90 6e-18
At4g21940 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 90 6e-18
7303051 [UT] KOG0662 Cyclin-dependent kinase CDK5 90 6e-18
7300106 [T] KOG0690 Serine/threonine protein kinase 90 6e-18
Hs4885061 [T] KOG0690 Serine/threonine protein kinase 90 8e-18
Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase 90 8e-18
ECU08g1920 [R] KOG0594 Protein kinase PCTAIRE and related kinases 90 8e-18
CE29298 [T] KOG0690 Serine/threonine protein kinase 90 8e-18
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 90 8e-18
CE18646 [T] KOG0690 Serine/threonine protein kinase 90 8e-18
At5g57630 [T] KOG0583 Serine/threonine protein kinase 90 8e-18
At4g30960 [T] KOG0583 Serine/threonine protein kinase 90 8e-18
At4g18700 [T] KOG0583 Serine/threonine protein kinase 90 8e-18
At1g07150 [T] KOG0198 MEKK and related serine/threonine protein ... 90 8e-18
7299437 [R] KOG0586 Serine/threonine protein kinase 90 8e-18
Hs4503069 [T] KOG0660 Mitogen-activated protein kinase 89 1e-17
Hs4502557 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 89 1e-17
Hs4502023 [T] KOG0690 Serine/threonine protein kinase 89 1e-17
Hs21361133 [R] KOG0586 Serine/threonine protein kinase 89 1e-17
Hs20986516 [T] KOG0660 Mitogen-activated protein kinase 89 1e-17
Hs20986514 [T] KOG0660 Mitogen-activated protein kinase 89 1e-17
Hs20986512 [T] KOG0660 Mitogen-activated protein kinase 89 1e-17
At5g38990 [T] KOG1187 Serine/threonine protein kinase 89 1e-17
At5g07070 [T] KOG0583 Serine/threonine protein kinase 89 1e-17
At3g29160 [T] KOG0583 Serine/threonine protein kinase 89 1e-17
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 89 1e-17
Hs4885347 [T] KOG0986 G protein-coupled receptor kinase 89 1e-17
Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 89 1e-17
Hs4501971 [T] KOG0986 G protein-coupled receptor kinase 89 1e-17
Hs19923134 [T] KOG4250 TANK binding protein kinase TBK1 89 1e-17
CE21879 [D] KOG0590 Checkpoint kinase and related serine/threoni... 89 1e-17
At1g79640 [T] KOG0582 Ste20-like serine/threonine protein kinase 89 1e-17
7302570 [R] KOG0586 Serine/threonine protein kinase 89 1e-17
7301972 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 89 1e-17
7301213 [R] KOG0589 Serine/threonine protein kinase 89 1e-17
7299438 [R] KOG0586 Serine/threonine protein kinase 89 1e-17
7296450 [D] KOG0575 Polo-like serine/threonine protein kinase 89 1e-17
CE22877 [D] KOG0575 Polo-like serine/threonine protein kinase 89 2e-17
CE02377 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 89 2e-17
At5g39000 [T] KOG1187 Serine/threonine protein kinase 89 2e-17
Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase 88 2e-17
CE21213 [UT] KOG0662 Cyclin-dependent kinase CDK5 88 2e-17
At5g45810 [T] KOG0583 Serine/threonine protein kinase 88 2e-17
At5g01810 [T] KOG0583 Serine/threonine protein kinase 88 2e-17
7293249 [T] KOG0612 Rho-associated coiled-coil containing protei... 88 2e-17
SPCC74.03c [T] KOG0583 Serine/threonine protein kinase 88 3e-17
Hs5453966 [T] KOG0583 Serine/threonine protein kinase 88 3e-17
Hs20127541 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 88 3e-17
Hs14770402 [R] KOG0586 Serine/threonine protein kinase 88 3e-17
Hs14670383 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 88 3e-17
Hs13376582 [T] KOG0198 MEKK and related serine/threonine protein... 88 3e-17
ECU07g0520 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 88 3e-17
At3g51850 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 88 3e-17
YDR507c [D] KOG0588 Serine/threonine protein kinase 87 4e-17
Hs20128774 [T] KOG0660 Mitogen-activated protein kinase 87 4e-17
CE23605 [T] KOG0665 Jun-N-terminal kinase (JNK) 87 4e-17
CE09360 [Z] KOG0613 Projectin/twitchin and related proteins 87 4e-17
At3g23000 [T] KOG0583 Serine/threonine protein kinase 87 4e-17
At3g17510 [T] KOG0583 Serine/threonine protein kinase 87 4e-17
Hs4758128_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 87 4e-17
YCL024w [T] KOG0583 Serine/threonine protein kinase 87 5e-17
CE29020 [T] KOG0660 Mitogen-activated protein kinase 87 5e-17
CE28650 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 87 5e-17
At5g23580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 87 5e-17
At5g10930 [T] KOG0583 Serine/threonine protein kinase 87 5e-17
At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GT... 87 5e-17
Hs14777335 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 87 7e-17
CE06503 [T] KOG0194 Protein tyrosine kinase 87 7e-17
At4g31170 [T] KOG0192 Tyrosine kinase specific for activated (GT... 87 7e-17
7294217 [D] KOG0588 Serine/threonine protein kinase 87 7e-17
Hs7706601 [T] KOG0192 Tyrosine kinase specific for activated (GT... 86 9e-17
Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved... 86 9e-17
Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 86 9e-17
Hs19526767 [T] KOG0192 Tyrosine kinase specific for activated (G... 86 9e-17
Hs14589904 [T] KOG0604 MAP kinase-activated protein kinase 2 86 9e-17
Hs13430860 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 86 9e-17
CE20636 [D] KOG0590 Checkpoint kinase and related serine/threoni... 86 9e-17
CE03584 [T] KOG0607 MAP kinase-interacting kinase and related se... 86 9e-17
CE00315 [R] KOG0594 Protein kinase PCTAIRE and related kinases 86 9e-17
At5g58380 [T] KOG0583 Serine/threonine protein kinase 86 9e-17
At4g14780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 86 9e-17
At2g42960 [T] KOG1187 Serine/threonine protein kinase 86 9e-17
YBR028c [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 86 1e-16
SPAC57A10.02 [D] KOG0588 Serine/threonine protein kinase 86 1e-16
SPAC23H4.02 [T] KOG0583 Serine/threonine protein kinase 86 1e-16
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 86 1e-16
Hs4505695 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 86 1e-16
Hs21040235 [R] KOG0594 Protein kinase PCTAIRE and related kinases 86 1e-16
Hs10863901 [T] KOG0604 MAP kinase-activated protein kinase 2 86 1e-16
CE28479 [T] KOG0583 Serine/threonine protein kinase 86 1e-16
At3g01090 [T] KOG0583 Serine/threonine protein kinase 86 1e-16
>YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 508
Score = 475 bits (1222), Expect = e-134
Identities = 235/349 (67%), Positives = 283/349 (80%), Gaps = 2/349 (0%)
Query: 118 TQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHE 177
+ S S SNLIS Y+ + S+S ES I + D D+L+ + W+ + +
Sbjct: 161 SNSVGSDFSNLISAYEQSSSPIKSSSQPKSSSESYIDLNSVRD-VDQLDENGWKYANLKD 219
Query: 178 QIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGS-EKQIFRELQFNKSCKSDF 236
+I+TLGILGEG GGSV+KCKL+NGSKIFALK I T+ D +KQIFRELQFN+S +S++
Sbjct: 220 RIETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEY 279
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IVRYYGMF +E S+I+IAMEYMGGRSLD++YK+LL +GGRI EKVLGKIAE+VLRGL Y
Sbjct: 280 IVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSY 339
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPY 356
LHE+K+IHRDIKPQNIL NE GQ+KLCDFGVSGEAVNSLATTFTGTS+YMAPERIQGQPY
Sbjct: 340 LHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQPY 399
Query: 357 SVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSK 416
SVTSDVWSLGLT+LEVA G P ++K+AAN+ P ELLM ILTFTPELKDEPE I+WS
Sbjct: 400 SVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSP 459
Query: 417 SFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQTCWAD 465
SFKSF+DY LKKDS++RPSPRQM+ HPW+ GQ KK+VNM+KF++ CW D
Sbjct: 460 SFKSFIDYCLKKDSRERPSPRQMINHPWIKGQMKKNVNMEKFVRKCWKD 508
>YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 506
Score = 464 bits (1194), Expect = e-130
Identities = 254/501 (50%), Positives = 318/501 (62%), Gaps = 40/501 (7%)
Query: 1 MASMFRPPESRRTNXXXXXXXXXXQLVSNSK-----------PITDIRDEKLRQXXXXXX 49
MASMFRPPES R++ LV N+K P + + +
Sbjct: 1 MASMFRPPESNRSHQKTPKLTLPVNLVQNAKSTNDGQHLNRSPYSSVNESPYSNNSTSAT 60
Query: 50 XXXXXXXXXXXXXXXR----TLKNRXX------XXXXXXXXXXXXXXNSGSAMGSLSNKL 99
R T+KNR S + + L
Sbjct: 61 STTSSMASNSTLLYNRSSTTTIKNRPVPPPLPPLVLTQKKDGIEYRVAGDSQLSERFSNL 120
Query: 100 H--------------GLKI-NTDHLPTSGSQQSTQSADSMTSNLISMYDSEPTTSSSTSL 144
H K+ N D + + DS S L+S YD + S+S L
Sbjct: 121 HVDITYKELLSSAPISTKLSNIDTTFIKKDLDTPEGEDSYPSTLLSAYDFSSSGSNSAPL 180
Query: 145 -VNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSK 203
N+ + +D D+LE + W+ + ++I TLGILGEG GGSV KC+L+NG K
Sbjct: 181 SANNIISCSNLIQGKD--VDQLEEEAWRFGHLKDEITTLGILGEGAGGSVAKCRLKNGKK 238
Query: 204 IFALKTIATIENDGS-EKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGR 262
+FALKTI T+ D +KQIFRELQFNKS KSD+IV+YYGMF E++S+I+IAMEYMGG+
Sbjct: 239 VFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGK 298
Query: 263 SLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKL 322
SL++ YK+LL +GGRI E+V+GKIAESVLRGL YLHERK+IHRDIKPQNIL NE G+IKL
Sbjct: 299 SLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKL 358
Query: 323 CDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTD 382
CDFGVSGEAVNSLA TFTGTS+YMAPERIQGQPYSVT DVWSLGLTLLEVA G PF++D
Sbjct: 359 CDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESD 418
Query: 383 KLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQH 442
K+ N+ PIELL +ILTF+P+LKDEPE I WSK+F+SF+DY LKKD+++RPSPRQML+H
Sbjct: 419 KITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKH 478
Query: 443 PWMVGQTKKHVNMKKFIQTCW 463
PW+VGQ KK VNM++F++ CW
Sbjct: 479 PWIVGQMKKKVNMERFVKKCW 499
>SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 309 bits (791), Expect = 7e-84
Identities = 168/331 (50%), Positives = 211/331 (62%), Gaps = 12/331 (3%)
Query: 140 SSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGIL-----GEGTGGSVT 194
SS S + KES + +EL+ D +HE + GIL GEG GSV
Sbjct: 40 SSESKLTQRKESRDSKTFVPSFLEELDDD-----HLHELVTNGGILYMNSLGEGVSGSVR 94
Query: 195 KCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFI 254
KC++R IFA+KT+ N +KQ+ REL+ N+SC S +IV+YYG + I
Sbjct: 95 KCRIRGTQMIFAMKTVLAAPNTALQKQLLRELKINRSCTSPYIVKYYGACYNNAECQLNI 154
Query: 255 AMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILF 314
AMEY G SLD++YK + S+GGR GE+ LGKIA VL GL YLH+RKIIHRDIKP NIL
Sbjct: 155 AMEYCGAGSLDAIYKRVRSQGGRTGERPLGKIAFGVLSGLSYLHDRKIIHRDIKPSNILL 214
Query: 315 NEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQ 374
GQ+KLCDFGVSGE VNSLA TFTGTSYYMAPERI G Y+++SD+WSLGLTL+EVA
Sbjct: 215 TSKGQVKLCDFGVSGELVNSLAGTFTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVAL 274
Query: 375 GHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRP 434
PF + M PIELL I+ P L + E GI WSKSF+ FL L KD RP
Sbjct: 275 NRFPFPPEGSPPPM-PIELLSYIINMPPPLLPQ-EPGIKWSKSFQHFLCVCLDKDKTRRP 332
Query: 435 SPRQMLQHPWMVGQTKKHVNMKKFIQTCWAD 465
P++ML HPW+ + HV+M++F++ W+D
Sbjct: 333 GPQKMLTHPWVKAFERIHVDMEEFLRQVWSD 363
>Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 448
Score = 196 bits (497), Expect = 8e-50
Identities = 130/350 (37%), Positives = 191/350 (54%), Gaps = 48/350 (13%)
Query: 99 LHGLKINTDHLPTSGSQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDR 158
+HGLK+NT P+ S + +DS+ SN + +E + +N
Sbjct: 117 IHGLKVNTRAGPSQHSSPAV--SDSLPSNSLKKSSAELKKILANGQMN------------ 162
Query: 159 DDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGS 218
E DI Y+ DTLG G GG+V K KI A+K I
Sbjct: 163 -------EQDI--RYR-----DTLG---HGNGGTVYKAYHVPSGKILAVKVILLDITLEL 205
Query: 219 EKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRI 278
+KQI EL+ C S +I+ +YG F E + I I E+M G SLD VY+ ++
Sbjct: 206 QKQIMSELEILYKCDSSYIIGFYGAFFVE--NRISICTEFMDGGSLD-VYR-------KM 255
Query: 279 GEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATT 338
E VLG+IA +V++GL YL KI+HRD+KP N+L N GQ+KLCDFGVS + VNS+A T
Sbjct: 256 PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT 315
Query: 339 FTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF-DTDKLAANMPPIELLMLI 397
+ GT+ YMAPERI G+ Y + SDVWSLG++ +E+A G P+ K ++ P++LL I
Sbjct: 316 YVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCI 375
Query: 398 LTFTPELKDEPEQGI-VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
+ +D P + +S+ F F+ ++K K+RP+P +++ HP++V
Sbjct: 376 VD-----EDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 420
>7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 396
Score = 194 bits (493), Expect = 2e-49
Identities = 118/286 (41%), Positives = 158/286 (54%), Gaps = 23/286 (8%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
E ++ LG LG G GG V K + + I A K I +KQI REL+ C
Sbjct: 85 EDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPH 144
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IV +YG F + I I MEYM G SLD + K + GRI E +LG+I +VL+GL Y
Sbjct: 145 IVGFYGAFYSD--GEISICMEYMDGGSLDLILK----RAGRIPESILGRITLAVLKGLSY 198
Query: 297 LHERK-IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQP 355
L + IIHRD+KP NIL N G+IK+CDFGVSG+ ++S+A +F GT YM+PER+QG
Sbjct: 199 LRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTH 258
Query: 356 YSVTSDVWSLGLTLLEVAQGHSPFDTDKLA------------ANMPPIE-LLMLILTFTP 402
YSV SD+WSLGL+L+E+A G P A + P E M I
Sbjct: 259 YSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLD 318
Query: 403 ELKDEPEQGI---VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ +EP + ++S FK F+D LKK +R + +L HPW+
Sbjct: 319 YIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI 364
>Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 393
Score = 187 bits (476), Expect = 2e-47
Identities = 128/346 (36%), Positives = 183/346 (51%), Gaps = 44/346 (12%)
Query: 137 TTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHE----QIDTLGILGEGTGGS 192
T+S+ T+L K+ E +E D + LE+ + Q K+ E + + LG G GG
Sbjct: 23 TSSAETNLEALQKKLEELELD-EQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGV 81
Query: 193 VTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTI 252
V K + + A K I QI RELQ C S +IV +YG F + I
Sbjct: 82 VFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSD--GEI 139
Query: 253 FIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER-KIIHRDIKPQN 311
I ME+M G SLD V K K GRI E++LGK++ +V++GL YL E+ KI+HRD+KP N
Sbjct: 140 SICMEHMDGGSLDQVLK----KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSN 195
Query: 312 ILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLE 371
IL N G+IKLCDFGVSG+ ++S+A +F GT YM+PER+QG YSV SD+WS+GL+L+E
Sbjct: 196 ILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVE 255
Query: 372 VAQGHSPF---DTDKL-----------AANMPPIELL---------------MLILTFTP 402
+A G P D +L AA PP M I
Sbjct: 256 MAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLD 315
Query: 403 ELKDEPEQGI---VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ +EP + V+S F+ F++ L K+ +R +Q++ H ++
Sbjct: 316 YIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361
>Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 438
Score = 187 bits (476), Expect = 2e-47
Identities = 127/349 (36%), Positives = 187/349 (53%), Gaps = 56/349 (16%)
Query: 99 LHGLKINTDHLPTSGSQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDR 158
+HGLK+NT P+ S + +DS+ SN + +E + +N
Sbjct: 117 IHGLKVNTRAGPSQHSSPAV--SDSLPSNSLKKSSAELKKILANGQMN------------ 162
Query: 159 DDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGS 218
E DI Y+ DTLG G GG+V K KI A+K I
Sbjct: 163 -------EQDI--RYR-----DTLG---HGNGGTVYKAYHVPSGKILAVKVILLDITLEL 205
Query: 219 EKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRI 278
+KQI EL+ C S +I+ +YG F E + I I E+M G SLD VY+ ++
Sbjct: 206 QKQIMSELEILYKCDSSYIIGFYGAFFVE--NRISICTEFMDGGSLD-VYR-------KM 255
Query: 279 GEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATT 338
E VLG+IA +V++GL YL KI+HRD+KP N+L N GQ+KLCDFGVS + VNS+A T
Sbjct: 256 PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT 315
Query: 339 FTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLIL 398
+ GT+ YMAPERI G+ Y + SDVWSLG++ +E+ K ++ P++LL I+
Sbjct: 316 YVGTNAYMAPERISGEQYGIHSDVWSLGISFMEI---------QKNQGSLMPLQLLQCIV 366
Query: 399 TFTPELKDEPEQGI-VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
+D P + +S+ F F+ ++K K+RP+P +++ HP++V
Sbjct: 367 D-----EDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 410
>Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 467
Score = 187 bits (476), Expect = 2e-47
Identities = 127/349 (36%), Positives = 187/349 (53%), Gaps = 56/349 (16%)
Query: 99 LHGLKINTDHLPTSGSQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDR 158
+HGLK+NT P+ S + +DS+ SN + +E + +N
Sbjct: 117 IHGLKVNTRAGPSQHSSPAV--SDSLPSNSLKKSSAELKKILANGQMN------------ 162
Query: 159 DDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGS 218
E DI Y+ DTLG G GG+V K KI A+K I
Sbjct: 163 -------EQDI--RYR-----DTLG---HGNGGTVYKAYHVPSGKILAVKVILLDITLEL 205
Query: 219 EKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRI 278
+KQI EL+ C S +I+ +YG F E + I I E+M G SLD VY+ ++
Sbjct: 206 QKQIMSELEILYKCDSSYIIGFYGAFFVE--NRISICTEFMDGGSLD-VYR-------KM 255
Query: 279 GEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATT 338
E VLG+IA +V++GL YL KI+HRD+KP N+L N GQ+KLCDFGVS + VNS+A T
Sbjct: 256 PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT 315
Query: 339 FTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLIL 398
+ GT+ YMAPERI G+ Y + SDVWSLG++ +E+ K ++ P++LL I+
Sbjct: 316 YVGTNAYMAPERISGEQYGIHSDVWSLGISFMEI---------QKNQGSLMPLQLLQCIV 366
Query: 399 TFTPELKDEPEQGI-VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
+D P + +S+ F F+ ++K K+RP+P +++ HP++V
Sbjct: 367 D-----EDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 410
>SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 340
Score = 186 bits (473), Expect = 5e-47
Identities = 113/277 (40%), Positives = 165/277 (58%), Gaps = 16/277 (5%)
Query: 170 WQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIF-ALKTIATIENDGSEKQIFRELQF 228
W + + ++ + LGEG GG+V+ K RN IF A KT+ + +KQI REL
Sbjct: 57 WISDLDNSSLEVVRHLGEGNGGAVSLVKHRN---IFMARKTVYVGSDSKLQKQILRELGV 113
Query: 229 NKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAE 288
C+S +IV +YG F + + I + MEYM SLD++ L +GG I +LGKI
Sbjct: 114 LHHCRSPYIVGFYGAF--QYKNNISLCMEYMDCGSLDAI----LREGGPIPLDILGKIIN 167
Query: 289 SVLRGLFYLHE-RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMA 347
S+++GL YL+ IIHRD+KP N++ N G+IKLCDFGVSGE VNS+A TF GTS YM+
Sbjct: 168 SMVKGLIYLYNVLHIIHRDLKPSNVVVNSRGEIKLCDFGVSGELVNSVAQTFVGTSTYMS 227
Query: 348 PERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDE 407
PERI+G Y+V SD+WSLG++++E+A P+ + ++ ++LL I+ P
Sbjct: 228 PERIRGGKYTVKSDIWSLGISIIELATQELPWSFSNIDDSIGILDLLHCIVQEEP----- 282
Query: 408 PEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPW 444
P + + + F+D L KD R SP+Q+ P+
Sbjct: 283 PRLPSSFPEDLRLFVDACLHKDPTLRASPQQLCAMPY 319
>Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 400
Score = 186 bits (471), Expect = 8e-47
Identities = 115/263 (43%), Positives = 156/263 (58%), Gaps = 14/263 (5%)
Query: 123 SMTSNLISMYDSEPTT--SSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHE--- 177
++T N PT+ +S +LV+ K+ E +E D + LE+ + Q K+ E
Sbjct: 11 ALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELD-EQQKKRLEAFLTQKAKVGELKD 69
Query: 178 -QIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
+ + LG G GG VTK + R I A K I QI RELQ C S +
Sbjct: 70 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPY 129
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IV +YG F + I I ME+M G SLD V K + RI E++LGK++ +VLRGL Y
Sbjct: 130 IVGFYGAFYSD--GEISICMEHMDGGSLDQVLK----EAKRIPEEILGKVSIAVLRGLAY 183
Query: 297 LHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQP 355
L E+ +I+HRD+KP NIL N G+IKLCDFGVSG+ ++S+A +F GT YMAPER+QG
Sbjct: 184 LREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTH 243
Query: 356 YSVTSDVWSLGLTLLEVAQGHSP 378
YSV SD+WS+GL+L+E+A G P
Sbjct: 244 YSVQSDIWSMGLSLVELAVGRYP 266
>Hs21729899 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 258
Score = 179 bits (453), Expect = 1e-44
Identities = 98/230 (42%), Positives = 146/230 (62%), Gaps = 17/230 (7%)
Query: 219 EKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRI 278
+KQI EL+ C S +I+ +YG F E + I I E+M G SLD VY+ ++
Sbjct: 16 QKQIMSELEILYKCDSSYIIGFYGAFFVE--NRISICTEFMDGGSLD-VYR-------KM 65
Query: 279 GEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATT 338
E VLG+IA +V++GL YL KI+HRD+KP N+L N GQ+KLCDFGVS + VNS+A T
Sbjct: 66 PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKT 125
Query: 339 FTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF-DTDKLAANMPPIELLMLI 397
+ GT+ YMAPERI G+ Y + SDVWSLG++ +E+A G P+ K ++ P++LL I
Sbjct: 126 YVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCI 185
Query: 398 LTFTPELKDEPEQGI-VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
+ +D P + +S+ F F+ ++K K+RP+P +++ HP++V
Sbjct: 186 VD-----EDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 230
>CE25437 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 387
Score = 174 bits (440), Expect = 3e-43
Identities = 95/203 (46%), Positives = 126/203 (61%), Gaps = 7/203 (3%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
+ + T G LG G GG V KC R I A K + +QI +EL C S F
Sbjct: 71 DMLQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNSPF 130
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IV +YG F + + I I MEYM G SLD V K K GR+ EK +G+I+ +V+RGL Y
Sbjct: 131 IVGFYGAFV--DNNDISICMEYMDGLSLDIVLK----KVGRLPEKFVGRISVAVVRGLTY 184
Query: 297 LHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQP 355
L + KI+HRD+KP N+L N G+IKLCDFGVSG ++S+A +F GT YMAPER+ G
Sbjct: 185 LKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSH 244
Query: 356 YSVTSDVWSLGLTLLEVAQGHSP 378
Y+++SD+WS GL+L+E+ G P
Sbjct: 245 YTISSDIWSFGLSLVELLIGRYP 267
>YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 515
Score = 169 bits (427), Expect = 1e-41
Identities = 123/342 (35%), Positives = 172/342 (49%), Gaps = 24/342 (7%)
Query: 114 SQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTY 173
S ST S SN+ + ++E + S E + D D L Y
Sbjct: 133 STNSTPSTIQGLSNIATPVENEHSISLPPL-------EESLSPAAADLKDTLSGTSNGNY 185
Query: 174 KIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSE-KQIFRELQFNKSC 232
+ + LG +G G G+V K SKI A KTI +N+ + Q+ REL K+
Sbjct: 186 IQLQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNV 245
Query: 233 KS-DFIVRYYGMFACEETST-IFIAMEYMGGRSLD---SVYKHLLSKGGRIGEKV----- 282
K + I+ +YG + + + I I MEY SLD SVYK + +G +K
Sbjct: 246 KPHENIITFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNEL 305
Query: 283 -LGKIAESVLRGLFYLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFT 340
+ KIA VL GL +L+ + KIIHRDIKP N+L N GQIKLCDFGVS + +NS+A TF
Sbjct: 306 TISKIAYGVLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFV 365
Query: 341 GTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTF 400
GTS YM+PERIQG YS+ DVWSLGL ++E+ G P N P +L L+
Sbjct: 366 GTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEFPLG----GHNDTPDGILDLLQRI 421
Query: 401 TPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQH 442
E + ++SK F++ K+ ++R S ++L H
Sbjct: 422 VNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLHH 463
>Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 334
Score = 168 bits (426), Expect = 1e-41
Identities = 104/296 (35%), Positives = 164/296 (55%), Gaps = 19/296 (6%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSD 235
+ ++ + LG G G V K + +I A+K I N +K++ +L + ++
Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
F V +YG E ++I ME M SLD YK ++ KG I E +LGKIA S+++ L
Sbjct: 111 FTVTFYGALFRE--GDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167
Query: 296 YLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERIQG 353
+LH + +IHRD+KP N+L N +GQ+K+CDFG+SG V+S+A T G YMAPERI
Sbjct: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINP 227
Query: 354 Q----PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
+ YSV SD+WSLG+T++E+A P+D + P +L ++ +P+L +
Sbjct: 228 ELNQKGYSVKSDIWSLGITMIELAILRFPYD----SWGTPFQQLKQVVEEPSPQLPADK- 282
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQTCWAD 465
+S F F LKK+SK+RP+ +++QHP+ K ++ F++ D
Sbjct: 283 ----FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 334
>Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 278
Score = 167 bits (423), Expect = 3e-41
Identities = 104/288 (36%), Positives = 160/288 (55%), Gaps = 19/288 (6%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSDFIVRYYGM 243
LG G G V K + +I A+K I N +K++ +L + ++ F V +YG
Sbjct: 3 LGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGA 62
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER-KI 302
E ++I ME M SLD YK ++ KG I E +LGKIA S+++ L +LH + +
Sbjct: 63 LFRE--GDMWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSV 119
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERIQGQ----PYS 357
IHRD+KP N+L N +GQ+K+CDFG+SG V+S+A T G YMAPERI + YS
Sbjct: 120 IHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYS 179
Query: 358 VTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKS 417
V SD+WSLG+T++E+A P+D + P +L ++ +P+L + +S
Sbjct: 180 VKSDIWSLGITMIELAILRFPYD----SWGTPFQQLKQVVEEPSPQLPADK-----FSAE 230
Query: 418 FKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQTCWAD 465
F F LKK+SK+RP+ +++QHP+ K ++ F++ D
Sbjct: 231 FVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD 278
>At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 354
Score = 163 bits (412), Expect = 6e-40
Identities = 100/271 (36%), Positives = 154/271 (55%), Gaps = 14/271 (5%)
Query: 179 IDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIV 238
++ + ++G+G+ G+V K + + FALK I + + + I +EL+ N S + ++V
Sbjct: 68 LEVIKVIGKGSSGNVQLVKHKLTQQFFALKVIQLNTEESTCRAISQELRINLSSQCPYLV 127
Query: 239 RYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
Y F + I +E+M G SL LL K G++ E +L I + VLRGL Y+H
Sbjct: 128 SCYQSFY--HNGLVSIILEFMDGGSLAD----LLKKVGKVPENMLSAICKRVLRGLCYIH 181
Query: 299 -ERKIIHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFTGTSYYMAPERIQGQP 355
ER+IIHRD+KP N+L N G++K+ DFGVS + +SLA +F GT YM+PERI G
Sbjct: 182 HERRIIHRDLKPSNLLINHRGEVKITDFGVSKILTSTSSLANSFVGTYPYMSPERISGSL 241
Query: 356 YSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPI-ELLMLILTFTPELKDEPEQGIVW 414
YS SD+WSLGL LLE A G P+ + + EL+ I+ P ++
Sbjct: 242 YSNKSDIWSLGLVLLECATGKFPYTPPEHKKGWSSVYELVDAIVENPPPCAPSN----LF 297
Query: 415 SKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
S F SF+ ++KD +DR S +++L+H ++
Sbjct: 298 SPEFCSFISQCVQKDPRDRKSAKELLEHKFV 328
>YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 668
Score = 162 bits (409), Expect = 1e-39
Identities = 108/293 (36%), Positives = 156/293 (52%), Gaps = 23/293 (7%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
++++ L LG G G+V+K + + I A K + ++ +QI EL+ C S +
Sbjct: 358 DELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCNSPY 417
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IV +YG F E +++ MEYM G SLD +Y GG I E L IA +V+ GL
Sbjct: 418 IVDFYGAFFIE--GAVYMCMEYMDGGSLDKIYDESSEIGG-IDEPQLAFIANAVIHGLKE 474
Query: 297 LHER-KIIHRDIKPQNILFN-EIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQG- 353
L E+ IIHRD+KP NIL + G +KLCDFGVSG V SLA T G YMAPERI+
Sbjct: 475 LKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSL 534
Query: 354 ----QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
Y+V SD+WSLGL++LE+A G P+ P E I + + D P
Sbjct: 535 NPDRATYTVQSDIWSLGLSILEMALGRYPY----------PPETYDNIFSQLSAIVDGPP 584
Query: 410 QGI---VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFI 459
+ +S + F+ L+K + RP+ + +HPW+V + V+M ++I
Sbjct: 585 PRLPSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWLVKYRNQDVHMSEYI 637
>Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 487
Score = 161 bits (408), Expect = 2e-39
Identities = 99/276 (35%), Positives = 155/276 (55%), Gaps = 19/276 (6%)
Query: 172 TYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKS 231
T + E D L LGEG+ GSV K + +I A+K + +E+D E I +E+ +
Sbjct: 23 TKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP-VESDLQE--IIKEISIMQQ 79
Query: 232 CKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVL 291
C S +V+YYG + + + ++I MEY G S+ + + + + E + I +S L
Sbjct: 80 CDSPHVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIIR---LRNKTLTEDEIATILQSTL 134
Query: 292 RGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPE 349
+GL YLH + IHRDIK NIL N G KL DFGV+G+ +++A T GT ++MAPE
Sbjct: 135 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 194
Query: 350 RIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
IQ Y+ +D+WSLG+T +E+A+G P+ A++ P+ + +I T P +PE
Sbjct: 195 VIQEIGYNCVADIWSLGITAIEMAEGKPPY------ADIHPMRAIFMIPTNPPPTFRKPE 248
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+WS +F F+ L K + R + Q+LQHP++
Sbjct: 249 ---LWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV 281
>Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 161 bits (408), Expect = 2e-39
Identities = 98/276 (35%), Positives = 156/276 (56%), Gaps = 19/276 (6%)
Query: 172 TYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKS 231
T + E D L LGEG+ GSV K + ++ A+K + +E+D E I +E+ +
Sbjct: 20 TKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVP-VESDLQE--IIKEISIMQQ 76
Query: 232 CKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVL 291
C S ++V+YYG + + + ++I MEY G S+ + + + + E + I +S L
Sbjct: 77 CDSPYVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIIR---LRNKTLIEDEIATILKSTL 131
Query: 292 RGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPE 349
+GL YLH + IHRDIK NIL N G KL DFGV+G+ +++A T GT ++MAPE
Sbjct: 132 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 191
Query: 350 RIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
IQ Y+ +D+WSLG+T +E+A+G P+ A++ P+ + +I T P +PE
Sbjct: 192 VIQEIGYNCVADIWSLGITSIEMAEGKPPY------ADIHPMRAIFMIPTNPPPTFRKPE 245
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+WS F F+ L K+ + R + Q+LQHP++
Sbjct: 246 ---LWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 278
>Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 161 bits (408), Expect = 2e-39
Identities = 98/276 (35%), Positives = 156/276 (56%), Gaps = 19/276 (6%)
Query: 172 TYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKS 231
T + E D L LGEG+ GSV K + ++ A+K + +E+D E I +E+ +
Sbjct: 20 TKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVP-VESDLQE--IIKEISIMQQ 76
Query: 232 CKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVL 291
C S ++V+YYG + + + ++I MEY G S+ + + + + E + I +S L
Sbjct: 77 CDSPYVVKYYGSYF--KNTDLWIVMEYCGAGSVSDIIR---LRNKTLIEDEIATILKSTL 131
Query: 292 RGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPE 349
+GL YLH + IHRDIK NIL N G KL DFGV+G+ +++A T GT ++MAPE
Sbjct: 132 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 191
Query: 350 RIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
IQ Y+ +D+WSLG+T +E+A+G P+ A++ P+ + +I T P +PE
Sbjct: 192 VIQEIGYNCVADIWSLGITSIEMAEGKPPY------ADIHPMRAIFMIPTNPPPTFRKPE 245
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+WS F F+ L K+ + R + Q+LQHP++
Sbjct: 246 ---LWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 278
>CE28674 [T] KOG0201 Serine/threonine protein kinase
Length = 651
Score = 161 bits (408), Expect = 2e-39
Identities = 94/272 (34%), Positives = 151/272 (54%), Gaps = 21/272 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+G G+ G V K ++ A+K I + + + I +E+Q C S ++ +Y+G F
Sbjct: 38 IGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSF 97
Query: 245 ACEETSTIFIAMEYMGGRS-LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ S ++I MEY+GG S LD L+K G++ E + I +L+GL YLH + I
Sbjct: 98 L--KGSKLWIIMEYLGGGSALD------LTKSGKLDESHIAVILREILKGLEYLHSERKI 149
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQGQPYSVTSD 361
HRDIK N+L +E G +K+ DFGV+G+ ++ TF G+ ++MAPE I+ Y +D
Sbjct: 150 HRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKAD 209
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSF 421
+WSLG+T +E+A G P +++ P+ +L LI P+ QG WSK FK F
Sbjct: 210 IWSLGITAIELANGEPPH------SDLHPMRVLFLI----PKNPPPVLQGSQWSKPFKEF 259
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHV 453
++ L KD ++RPS +L+H ++ K +
Sbjct: 260 VEMCLNKDPENRPSASTLLKHQFIKRAKKNSI 291
>CE07510 [T] KOG0201 Serine/threonine protein kinase
Length = 653
Score = 161 bits (408), Expect = 2e-39
Identities = 94/272 (34%), Positives = 151/272 (54%), Gaps = 21/272 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+G G+ G V K ++ A+K I + + + I +E+Q C S ++ +Y+G F
Sbjct: 40 IGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSF 99
Query: 245 ACEETSTIFIAMEYMGGRS-LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ S ++I MEY+GG S LD L+K G++ E + I +L+GL YLH + I
Sbjct: 100 L--KGSKLWIIMEYLGGGSALD------LTKSGKLDESHIAVILREILKGLEYLHSERKI 151
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQGQPYSVTSD 361
HRDIK N+L +E G +K+ DFGV+G+ ++ TF G+ ++MAPE I+ Y +D
Sbjct: 152 HRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKAD 211
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSF 421
+WSLG+T +E+A G P +++ P+ +L LI P+ QG WSK FK F
Sbjct: 212 IWSLGITAIELANGEPPH------SDLHPMRVLFLI----PKNPPPVLQGSQWSKPFKEF 261
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHV 453
++ L KD ++RPS +L+H ++ K +
Sbjct: 262 VEMCLNKDPENRPSASTLLKHQFIKRAKKNSI 293
>7292830 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 334
Score = 161 bits (408), Expect = 2e-39
Identities = 103/290 (35%), Positives = 159/290 (54%), Gaps = 19/290 (6%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSD 235
+ ++ + LG G G V K + + + A+K I N + ++ +L + +S
Sbjct: 44 DSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCP 103
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
+ V +YG A ++I ME M SLD Y + R+ E VLGKIA SV+ L
Sbjct: 104 YTVHFYG--AMYREGDVWICMEVMS-TSLDKFYPKVFLHDLRMEESVLGKIAMSVVSALH 160
Query: 296 YLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERI-- 351
YLH + K+IHRD+KP NIL N GQ+K+CDFG+SG V+S+A T G YMAPERI
Sbjct: 161 YLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDP 220
Query: 352 QGQP--YSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
QG P Y + SDVWSLG+ ++E+A G P+D + P E L ++ +P E
Sbjct: 221 QGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWR-----TPFEQLRQVVEDSPPRLPEG- 274
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFI 459
+S F+ F+ L+K+ RP+ Q+L+H ++V +++ ++ +F+
Sbjct: 275 ---TFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFV 321
>At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 520
Score = 160 bits (405), Expect = 4e-39
Identities = 113/348 (32%), Positives = 173/348 (49%), Gaps = 18/348 (5%)
Query: 117 STQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIH 176
S+ S D S L+S + S S + N + ++ DE ES
Sbjct: 23 SSSSLDPNDSYLLSDGGTVNLLSRSYGVYNFNELG--LQKCTSSHVDESESSETTYQCAS 80
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
++ G +G G V + +I ALK I E + ++ + ++ +
Sbjct: 81 HEMRVFGAIGSGASSVVQRAIHIPNHRILALKKINIFEREKRQQLLTEIRTLCEAPCHEG 140
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
+V ++G F ++ I IA+EYM G SL + K ++K +I E VL + +L+GL Y
Sbjct: 141 LVDFHGAFYSPDSGQISIALEYMNGGSLADILK--VTK--KIPEPVLSSLFHKLLQGLSY 196
Query: 297 LHE-RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERIQG 353
LH R ++HRDIKP N+L N G+ K+ DFG+S NS+A TF GT YM+PERI+
Sbjct: 197 LHGVRHLVHRDIKPANLLINLKGEPKITDFGISAGLENSMAMCATFVGTVTYMSPERIRN 256
Query: 354 QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
YS +D+WSLGL L E G P+ AN P+ L++ IL + E
Sbjct: 257 DSYSYPADIWSLGLALFECGTGEFPY-----IANEGPVNLMLQILDDPSPTPPKQE---- 307
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQT 461
+S F SF+D L+KD RP+ Q+L HP++ K+ V++ F+Q+
Sbjct: 308 FSPEFCSFIDACLQKDPDARPTADQLLSHPFITKHEKERVDLATFVQS 355
>CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 525
Score = 159 bits (403), Expect = 6e-39
Identities = 95/293 (32%), Positives = 161/293 (54%), Gaps = 20/293 (6%)
Query: 156 HDRDDSTDELESDIWQTYKIHEQI-DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIE 214
+ + S+D + D K E++ D +G LGEG+ GSV K R + A+K +
Sbjct: 39 NSEEGSSDGFKLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPV-- 96
Query: 215 NDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSK 274
D ++I +E+ + CKS ++V+YYG + + S ++I MEY G S+ + + ++
Sbjct: 97 -DTDLQEIIKEISIMQQCKSKYVVKYYGSYF--KHSDLWIVMEYCGAGSISDIMR---AR 150
Query: 275 GGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS 334
+ E+ + + L+GL YLH+ K IHRDIK NIL N G KL DFGV+G+ ++
Sbjct: 151 RKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDT 210
Query: 335 LA--TTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIE 392
+A T GT ++MAPE I+ Y +D+WSLG+T +E+A+G P+ +++ P+
Sbjct: 211 MAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPY------SDIHPMR 264
Query: 393 LLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ +I T P +PE+ WS F F+ L K ++R + ++ +H ++
Sbjct: 265 AIFMIPTKPPPTFKKPEE---WSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 314
>CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 640
Score = 159 bits (403), Expect = 6e-39
Identities = 95/293 (32%), Positives = 161/293 (54%), Gaps = 20/293 (6%)
Query: 156 HDRDDSTDELESDIWQTYKIHEQI-DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIE 214
+ + S+D + D K E++ D +G LGEG+ GSV K R + A+K +
Sbjct: 11 NSEEGSSDGFKLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPV-- 68
Query: 215 NDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSK 274
D ++I +E+ + CKS ++V+YYG + + S ++I MEY G S+ + + ++
Sbjct: 69 -DTDLQEIIKEISIMQQCKSKYVVKYYGSYF--KHSDLWIVMEYCGAGSISDIMR---AR 122
Query: 275 GGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS 334
+ E+ + + L+GL YLH+ K IHRDIK NIL N G KL DFGV+G+ ++
Sbjct: 123 RKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDT 182
Query: 335 LA--TTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIE 392
+A T GT ++MAPE I+ Y +D+WSLG+T +E+A+G P+ +++ P+
Sbjct: 183 MAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPY------SDIHPMR 236
Query: 393 LLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ +I T P +PE+ WS F F+ L K ++R + ++ +H ++
Sbjct: 237 AIFMIPTKPPPTFKKPEE---WSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 286
>CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 421
Score = 159 bits (403), Expect = 6e-39
Identities = 95/293 (32%), Positives = 161/293 (54%), Gaps = 20/293 (6%)
Query: 156 HDRDDSTDELESDIWQTYKIHEQI-DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIE 214
+ + S+D + D K E++ D +G LGEG+ GSV K R + A+K +
Sbjct: 11 NSEEGSSDGFKLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPV-- 68
Query: 215 NDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSK 274
D ++I +E+ + CKS ++V+YYG + + S ++I MEY G S+ + + ++
Sbjct: 69 -DTDLQEIIKEISIMQQCKSKYVVKYYGSYF--KHSDLWIVMEYCGAGSISDIMR---AR 122
Query: 275 GGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS 334
+ E+ + + L+GL YLH+ K IHRDIK NIL N G KL DFGV+G+ ++
Sbjct: 123 RKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDT 182
Query: 335 LA--TTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIE 392
+A T GT ++MAPE I+ Y +D+WSLG+T +E+A+G P+ +++ P+
Sbjct: 183 MAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPY------SDIHPMR 236
Query: 393 LLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ +I T P +PE+ WS F F+ L K ++R + ++ +H ++
Sbjct: 237 AIFMIPTKPPPTFKKPEE---WSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 286
>CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 523
Score = 159 bits (403), Expect = 6e-39
Identities = 95/293 (32%), Positives = 161/293 (54%), Gaps = 20/293 (6%)
Query: 156 HDRDDSTDELESDIWQTYKIHEQI-DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIE 214
+ + S+D + D K E++ D +G LGEG+ GSV K R + A+K +
Sbjct: 39 NSEEGSSDGFKLDSSALNKPPEEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPV-- 96
Query: 215 NDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSK 274
D ++I +E+ + CKS ++V+YYG + + S ++I MEY G S+ + + ++
Sbjct: 97 -DTDLQEIIKEISIMQQCKSKYVVKYYGSYF--KHSDLWIVMEYCGAGSISDIMR---AR 150
Query: 275 GGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS 334
+ E+ + + L+GL YLH+ K IHRDIK NIL N G KL DFGV+G+ ++
Sbjct: 151 RKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDT 210
Query: 335 LA--TTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIE 392
+A T GT ++MAPE I+ Y +D+WSLG+T +E+A+G P+ +++ P+
Sbjct: 211 MAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPY------SDIHPMR 264
Query: 393 LLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ +I T P +PE+ WS F F+ L K ++R + ++ +H ++
Sbjct: 265 AIFMIPTKPPPTFKKPEE---WSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 314
>7300224 [T] KOG0201 Serine/threonine protein kinase
Length = 642
Score = 159 bits (403), Expect = 6e-39
Identities = 95/264 (35%), Positives = 149/264 (55%), Gaps = 22/264 (8%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+G+G+ G V K ++ A+K I E + I +E+ C S ++ +YYG F
Sbjct: 19 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPYVTKYYGSF 78
Query: 245 ACEETSTIFIAMEYMGGRS-LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ + ++I MEY+GG S LD L K G E +G I VL+GL YLH + +
Sbjct: 79 L--KGTKLWIIMEYLGGGSALD------LMKAGSFEEMHIGIILREVLKGLDYLHSERKL 130
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAVN--SLATTFTGTSYYMAPERIQGQPYSVTSD 361
HRDIK N+L +E G +KL DFGV+G+ N S TF GT ++MAPE I+ Y +D
Sbjct: 131 HRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKAD 190
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSF 421
+WSLG+T +E+A+G P + + P+ +L LI P P+ ++KSFK F
Sbjct: 191 IWSLGITAIELAKGEPP------NSELHPMRVLFLIPKNNP-----PQLTGSYTKSFKDF 239
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWM 445
++ L KD ++RP+ +++L++P++
Sbjct: 240 VEACLNKDPENRPTAKELLKYPFI 263
>Hs15011880 [T] KOG0201 Serine/threonine protein kinase
Length = 416
Score = 159 bits (401), Expect = 1e-38
Identities = 97/270 (35%), Positives = 151/270 (55%), Gaps = 22/270 (8%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+G+G+ G V K ++ A+K I E + + I +E+ C S ++ +YYG +
Sbjct: 30 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSY 89
Query: 245 ACEETSTIFIAMEYMGGRS-LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ S ++I MEY+GG S LD L + G E + + + +L+GL YLH K I
Sbjct: 90 L--KGSKLWIIMEYLGGGSALD------LLRAGPFDEFQIATMLKEILKGLDYLHSEKKI 141
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAVNS--LATTFTGTSYYMAPERIQGQPYSVTSD 361
HRDIK N+L +E G +KL DFGV+G+ ++ TF GT ++MAPE IQ Y +D
Sbjct: 142 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKAD 201
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSF 421
+WSLG+T +E+A+G P ++M P+ +L LI P P ++KSFK F
Sbjct: 202 IWSLGITAIELAKGEPP------NSDMHPMRVLFLIPKNNP-----PTLVGDFTKSFKEF 250
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWMVGQTKK 451
+D L KD RP+ +++L+H ++V +KK
Sbjct: 251 IDACLNKDPSFRPTAKELLKHKFIVKNSKK 280
>CE07399 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 343
Score = 159 bits (401), Expect = 1e-38
Identities = 110/282 (39%), Positives = 155/282 (54%), Gaps = 18/282 (6%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQF-NKSCKSDFIVRYYGM 243
LG+G G V K + R I A+K I + ND S+KQ+ EL +S +VR+YG
Sbjct: 56 LGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGA 115
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER-KI 302
E ++I ME M SLD Y+H G I E +GK+A SV+ GL ++ E+ +
Sbjct: 116 MFRE--GDVWICMEVMD-TSLDKFYRHAYKIGKHIPEPFIGKMALSVIEGLNFMKEQLNL 172
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERIQGQ---PYSV 358
IHRD+KP NIL N GQ+K+CDFG+SG NS+A T G YM PERI G+ Y V
Sbjct: 173 IHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDV 232
Query: 359 TSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSF 418
+DVWSLG+T++E+A G P+ K P E L ++ P K E G +S
Sbjct: 233 RADVWSLGITIIEIAVGTHPYANWK-----TPFEQLKQVVK-EPPPKLPMESG--FSVDC 284
Query: 419 KSFLDYSLKKDSKDRPSPRQMLQHPWM-VGQTKKHVNMKKFI 459
+ F+ L+KD +RP ++L P+M + +K +M +FI
Sbjct: 285 QYFVKRCLEKDYNERPKYPELLAMPFMEQARNEKQFSMARFI 326
>Hs4506889 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 399
Score = 157 bits (398), Expect = 2e-38
Identities = 108/291 (37%), Positives = 162/291 (55%), Gaps = 17/291 (5%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQF-NKSCKSD 235
E + LG +G G GSV K + +I A+K I + ++ +KQ+ +L +S
Sbjct: 100 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 159
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSK-GGRIGEKVLGKIAESVLRGL 294
+IV++YG E +I ME M S D YK++ S I E++LGKI + ++ L
Sbjct: 160 YIVQFYGALFRE--GDCWICMELMS-TSFDKFYKYVYSVLDDVIPEEILGKITLATVKAL 216
Query: 295 FYLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA-TTFTGTSYYMAPERI- 351
+L E KIIHRDIKP NIL + G IKLCDFG+SG+ V+S+A T G YMAPERI
Sbjct: 217 NHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERID 276
Query: 352 ---QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEP 408
Q Y V SDVWSLG+TL E+A G P+ N +L ++ P+L +
Sbjct: 277 PSASRQGYDVRSDVWSLGITLYELATGRFPYP----KWNSVFDQLTQVVKGDPPQLSNSE 332
Query: 409 EQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFI 459
E+ +S SF +F++ L KD RP +++L+HP+++ ++ V + ++
Sbjct: 333 ER--EFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYV 381
>HsM5454174 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 156 bits (395), Expect = 5e-38
Identities = 96/278 (34%), Positives = 154/278 (54%), Gaps = 22/278 (7%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
E L +G+G+ G V K + ++ A+K I E + + I +E+ C S +
Sbjct: 18 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPY 77
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRS-LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
I RY+G + +++ ++I MEY+GG S LD L K G + E + I +L+GL
Sbjct: 78 ITRYFGSYL--KSTKLWIIMEYLGGGSALD------LLKPGPLEETYIATILREILKGLD 129
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS--LATTFTGTSYYMAPERIQG 353
YLH + IHRDIK N+L +E G +KL DFGV+G+ ++ TF GT ++MAPE I+
Sbjct: 130 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 189
Query: 354 QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
Y +D+WSLG+T +E+A+G P +++ P+ +L LI +P +
Sbjct: 190 SAYDFKADIWSLGITAIELAKGEPP------NSDLHPMRVLFLIPKNSPPTLEGQH---- 239
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKK 451
SK FK F++ L KD + RP+ +++L+H ++ TKK
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK 276
>Hs21361358 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 156 bits (395), Expect = 5e-38
Identities = 96/278 (34%), Positives = 154/278 (54%), Gaps = 22/278 (7%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
E L +G+G+ G V K + ++ A+K I E + + I +E+ C S +
Sbjct: 18 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPY 77
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRS-LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
I RY+G + +++ ++I MEY+GG S LD L K G + E + I +L+GL
Sbjct: 78 ITRYFGSYL--KSTKLWIIMEYLGGGSALD------LLKPGPLEETYIATILREILKGLD 129
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS--LATTFTGTSYYMAPERIQG 353
YLH + IHRDIK N+L +E G +KL DFGV+G+ ++ TF GT ++MAPE I+
Sbjct: 130 YLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ 189
Query: 354 QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
Y +D+WSLG+T +E+A+G P +++ P+ +L LI +P +
Sbjct: 190 SAYDFKADIWSLGITAIELAKGEPP------NSDLHPMRVLFLIPKNSPPTLEGQH---- 239
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKK 451
SK FK F++ L KD + RP+ +++L+H ++ TKK
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK 276
>7299057 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 424
Score = 156 bits (394), Expect = 7e-38
Identities = 106/291 (36%), Positives = 160/291 (54%), Gaps = 17/291 (5%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQF-NKSCKSD 235
+ ++ G +G G G+V K + K+ A+K I + ++ +KQ+ +L+ KS +
Sbjct: 120 DDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECI 179
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGR-IGEKVLGKIAESVLRGL 294
+IV++YG A + +I ME M SLD YK++ K R I E +L KI + + L
Sbjct: 180 YIVQFYG--ALFKEGDCWICMELMD-TSLDKFYKYIYEKQQRHIPESILAKITVATVNAL 236
Query: 295 FYLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA-TTFTGTSYYMAPERI- 351
YL E KIIHRD+KP NIL + G IKLCDFG+SG+ V+S+A T G YMAPERI
Sbjct: 237 NYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERID 296
Query: 352 --QGQPYSVTSDVWSLGLTLLEVAQGHSPF-DTDKLAANMPPIELLMLILTFTPELKDEP 408
+ + Y V SDVWSLG+TL+EVA G+ P+ D + E L ++ P
Sbjct: 297 PERAKGYDVRSDVWSLGITLMEVATGNFPYRKWDSV------FEQLCQVVQGEPPRLLTS 350
Query: 409 EQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFI 459
G+ +SK F F++ L K DRP ++L+ P++ H ++ ++
Sbjct: 351 YNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFIRRGETSHTDVAVYV 401
>SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 605
Score = 154 bits (389), Expect = 3e-37
Identities = 107/286 (37%), Positives = 147/286 (50%), Gaps = 23/286 (8%)
Query: 178 QIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFI 237
+I L LG+G G V K + ALK I + + QI EL S +I
Sbjct: 319 EIIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSLEEATFNQIIMELDILHKAVSPYI 378
Query: 238 VRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYL 297
V +YG F E ++FI MEYM S+D +Y GG E VL + A +V++GL L
Sbjct: 379 VDFYGAFFVE--GSVFICMEYMDAGSMDKLYA-----GGIKDEGVLARTAYAVVQGLKTL 431
Query: 298 -HERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQ-GQP 355
E IIHRD+KP N+L N GQ+KLCDFGVSG V S++ T G YMAPERI+ G P
Sbjct: 432 KEEHNIIHRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISKTNIGCQSYMAPERIRVGGP 491
Query: 356 ------YSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
Y+V +DVWSLGLT+LE+A G P+ + + +L + P L D
Sbjct: 492 TNGVLTYTVQADVWSLGLTILEMALGAYPYPPESYTSIF--AQLSAICDGDPPSLPDS-- 547
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNM 455
+S + F++ L K+ RP ++ HPW++ V+M
Sbjct: 548 ----FSPEARDFVNKCLNKNPSLRPDYHELANHPWLLKYQNADVDM 589
>7302458 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 596
Score = 154 bits (388), Expect = 4e-37
Identities = 96/285 (33%), Positives = 151/285 (52%), Gaps = 19/285 (6%)
Query: 180 DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVR 239
D + LGEG+ GSV K + S I A+K + +E+D E I +E+ + C S ++VR
Sbjct: 43 DIMYKLGEGSYGSVYKAVHKESSSIVAIKLVP-VESDLHE--IIKEISIMQQCDSPYVVR 99
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
YYG + + ++I MEY G S+ + + + + E + I L+GL YLH
Sbjct: 100 YYGSYF--KQYDLWICMEYCGAGSVSDIMR---LRKKTLTEDEIATILSDTLQGLVYLHL 154
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERIQGQPYS 357
R+ IHRDIK NIL N G KL DFGV+G+ +++A T GT ++MAPE I+ Y
Sbjct: 155 RRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYD 214
Query: 358 VTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKS 417
+D+WSLG+T LE+A+G P+ + P+ + +I P EP++ WS
Sbjct: 215 CVADIWSLGITALEMAEGKPPY------GEIHPMRAIFMIPQKPPPSFREPDR---WSTE 265
Query: 418 FKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQTC 462
F F+ L K+ DR + ++L+H ++ + + +TC
Sbjct: 266 FIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETC 310
>At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 310
Score = 153 bits (387), Expect = 5e-37
Identities = 96/274 (35%), Positives = 149/274 (54%), Gaps = 21/274 (7%)
Query: 179 IDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIV 238
++ L +LG G GG V K + + S+I+ALKT+ + +Q+ RE++ + S ++V
Sbjct: 47 LEKLNVLGCGNGGIVYKVRHKTTSEIYALKTVNGDMDPIFTRQLMREMEILRRTDSPYVV 106
Query: 239 RYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
+ +G+F + I MEYM G +L+S+ +GG +K+ G A+ +L+GL YLH
Sbjct: 107 KCHGIFEKPVVGEVSILMEYMDGGTLESL------RGGVTEQKLAG-FAKQILKGLSYLH 159
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQGQPY 356
KI+HRDIKP N+L N ++K+ DFGVS V SL ++ GT YM+PER +
Sbjct: 160 ALKIVHRDIKPANLLLNSKNEVKIADFGVSKILVRSLDSCNSYVGTCAYMSPERFDSESS 219
Query: 357 SVTS-----DVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQG 411
+S D+WS GL +LE+ GH P P LM + F + P
Sbjct: 220 GGSSDIYAGDIWSFGLMMLELLVGHFPL---LPPGQRPDWATLMCAVCF----GEPPRAP 272
Query: 412 IVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
S+ F+SF++ L+KDS R + Q+L HP++
Sbjct: 273 EGCSEEFRSFVECCLRKDSSKRWTAPQLLAHPFL 306
>Hs21618351 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 352
Score = 153 bits (386), Expect = 6e-37
Identities = 115/368 (31%), Positives = 184/368 (49%), Gaps = 44/368 (11%)
Query: 113 GSQQSTQSADSMTSNLISMYD-------------SEPTTSSSTSLVNHGKESEIIEHDRD 159
G Q + S DS T +L+S+ S+P + T N + I DR+
Sbjct: 2 GVQGTLMSRDSQTPHLLSILGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRN 61
Query: 160 DSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSE 219
E+E+D + T+ LG G G V K + I A+K I N +
Sbjct: 62 F---EVEAD---------DLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQ 109
Query: 220 KQIFRELQFN-KSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRI 278
K++ +L N ++ + V +YG E ++I ME M SLD Y+ +L K I
Sbjct: 110 KRLLMDLDINMRTVDCFYTVTFYGALFRE--GDVWICMELMD-TSLDKFYRKVLDKNMTI 166
Query: 279 GEKVLGKIAESVLRGLFYLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLAT 337
E +LG+IA S++R L +LH + +IHRD+KP N+L N+ G +K+CDFG+SG V+S+A
Sbjct: 167 PEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAK 226
Query: 338 TF-TGTSYYMAPERIQGQ----PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIE 392
T G YMAPERI + Y+V SDVWSLG+T++E+A P++ + P +
Sbjct: 227 TMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYE----SWGTPFQQ 282
Query: 393 LLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKH 452
L ++ +P+L + +S F F L+K+ +R S ++++HP+ K
Sbjct: 283 LKQVVEEPSPQLPADR-----FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKK 337
Query: 453 VNMKKFIQ 460
++ F++
Sbjct: 338 TDIAAFVK 345
>At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 356
Score = 153 bits (386), Expect = 6e-37
Identities = 101/312 (32%), Positives = 159/312 (50%), Gaps = 20/312 (6%)
Query: 155 EHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIE 214
+ R + EL+ +I E ++T+ ++G+G+GG V + + K FA+K I
Sbjct: 51 KQSRQSDSKELDFEITA-----EDLETVKVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNI 105
Query: 215 NDGSEKQIFRELQFNKSCKS--DFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLL 272
+ KQI +EL+ N++ +V Y+ + + +EYM SL V + +
Sbjct: 106 QEEIRKQIVQELKINQASSQCPHVVVCYHSFY---HNGAFSLVLEYMDRGSLADVIRQVK 162
Query: 273 SKGGRIGEKVLGKIAESVLRGLFYLH-ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEA 331
+ I E L + + VL GL YLH ER +IHRDIKP N+L N G++K+ DFGVS
Sbjct: 163 T----ILEPYLAVVCKQVLLGLVYLHNERHVIHRDIKPSNLLVNHKGEVKISDFGVSASL 218
Query: 332 VNSLAT--TFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMP 389
+S+ TF GT YM+PERI G Y +SD+WSLG+++LE A G P+ + N P
Sbjct: 219 ASSMGQRDTFVGTYNYMSPERISGSTYDYSSDIWSLGMSVLECAIGRFPYLESEDQQNPP 278
Query: 390 PIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQT 449
L+ + P +Q +S F SF+ ++KD R S +L HP++
Sbjct: 279 SFYELLAAIVENPPPTAPSDQ---FSPEFCSFVSACIQKDPPARASSLDLLSHPFIKKFE 335
Query: 450 KKHVNMKKFIQT 461
K +++ + T
Sbjct: 336 DKDIDLGILVGT 347
>CE24941 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 435
Score = 152 bits (384), Expect = 1e-36
Identities = 105/304 (34%), Positives = 159/304 (51%), Gaps = 27/304 (8%)
Query: 158 RDDSTDELESDIWQTYKIH--------------EQIDTLGILGEGTGGSVTKCKLRNGSK 203
RD D LE + + YK +I + +LG G+ G V +R SK
Sbjct: 87 RDTEKDALEYEFLEGYKKSGTLEIDGEKQVVDPNEIHIISLLGSGSCGVVESATVR--SK 144
Query: 204 IFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRS 263
+ A+KT+ +N + K+I R+++ C S FIV YG F + S++ I M+ M
Sbjct: 145 LMAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFD--SSVKICMQIMSACC 202
Query: 264 LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER-KIIHRDIKPQNILFNEIGQIKL 322
+ + SK E V G I S + L YL E+ IIHRDIKP NILF++ G +KL
Sbjct: 203 EKLLRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKL 262
Query: 323 CDFGVSGEAVNSLA-TTFTGTSYYMAPERI---QGQPYSVTSDVWSLGLTLLEVAQGHSP 378
CDFG+SG +S+A + G YMAPER+ Y V SDVWSLG+T+ ++ G P
Sbjct: 263 CDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTGLYP 322
Query: 379 FDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQ 438
F + + + ++ + +P L++E ++ +S F FLD L+KD ++RP RQ
Sbjct: 323 FPLNDM--EFTTLTIIANLNLPSPSLREETKRS--FSPLFIEFLDLCLRKDVRERPEYRQ 378
Query: 439 MLQH 442
+++H
Sbjct: 379 LMKH 382
>Hs20070158 [T] KOG0201 Serine/threonine protein kinase
Length = 443
Score = 151 bits (382), Expect = 2e-36
Identities = 92/270 (34%), Positives = 149/270 (55%), Gaps = 22/270 (8%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+G+G+ G V K K+ A+K I E + + I +E+ C S ++ +YYG +
Sbjct: 42 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 101
Query: 245 ACEETSTIFIAMEYMGGRS-LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ + ++I MEY+GG S LD L + G + E + I +L+GL YLH K I
Sbjct: 102 L--KDTKLWIIMEYLGGGSALD------LLEPGPLDETQIATILREILKGLDYLHSEKKI 153
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAVNS--LATTFTGTSYYMAPERIQGQPYSVTSD 361
HRDIK N+L +E G++KL DFGV+G+ ++ TF GT ++MAPE I+ Y +D
Sbjct: 154 HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKAD 213
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSF 421
+WSLG+T +E+A+G P + + P+++L LI P P +SK K F
Sbjct: 214 IWSLGITAIELARGEPPH------SELHPMKVLFLIPKNNP-----PTLEGNYSKPLKEF 262
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWMVGQTKK 451
++ L K+ RP+ +++L+H +++ KK
Sbjct: 263 VEACLNKEPSFRPTAKELLKHKFILRNAKK 292
>At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 151 bits (382), Expect = 2e-36
Identities = 98/288 (34%), Positives = 149/288 (51%), Gaps = 22/288 (7%)
Query: 179 IDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIV 238
+D + ++G+G+ G V + + + FALK I ++ K I +EL+ N+S + +V
Sbjct: 70 LDMVKVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQSSQCPNLV 129
Query: 239 RYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
Y F + I + +EYM G SL K + + I + L I VL+GL YLH
Sbjct: 130 TSYQSFY--DNGAISLILEYMDGGSLADFLKSVKA----IPDSYLSAIFRQVLQGLIYLH 183
Query: 299 -ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS--LATTFTGTSYYMAPERIQGQP 355
+R IIHRD+KP N+L N G++K+ DFGVS N+ LA TF GT YM+PERI G
Sbjct: 184 HDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNK 243
Query: 356 YSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPP--IELLMLILTFTPELKDEPEQGIV 413
Y SD+WSLGL +LE A G P+ PP E + + D+P +
Sbjct: 244 YGNKSDIWSLGLVVLECATGKFPY--------APPNQEETWTSVFELMEAIVDQPPPALP 295
Query: 414 ---WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKF 458
+S SF+ L+KD R S +++++HP++ +N+ +
Sbjct: 296 SGNFSPELSSFISTCLQKDPNSRSSAKELMEHPFLNKYDYSGINLASY 343
>Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 419
Score = 151 bits (381), Expect = 2e-36
Identities = 101/275 (36%), Positives = 152/275 (54%), Gaps = 22/275 (8%)
Query: 179 IDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSDFI 237
++ LG +G GT G V K + R + A+K + N K+I +L KS +I
Sbjct: 120 LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYI 179
Query: 238 VRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYL 297
V+ +G F + +FIAME MG + + K + G I E++LGK+ ++++ L+YL
Sbjct: 180 VQCFGTFITN--TDVFIAMELMG-TCAEKLKKRMQ---GPIPERILGKMTVAIVKALYYL 233
Query: 298 HERK-IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA-TTFTGTSYYMAPERIQ--- 352
E+ +IHRD+KP NIL +E GQIKLCDFG+SG V+S A T G + YMAPERI
Sbjct: 234 KEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 293
Query: 353 --GQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQ 410
Y + +DVWSLG++L+E+A G P+ K E+L +L P L
Sbjct: 294 PTKPDYDIRADVWSLGISLVELATGQFPYKNCK-----TDFEVLTKVLQEEPPLL---PG 345
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ +S F+SF+ L KD + RP ++L+H ++
Sbjct: 346 HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI 380
>HsM4506099 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 318
Score = 150 bits (379), Expect = 4e-36
Identities = 97/291 (33%), Positives = 157/291 (53%), Gaps = 19/291 (6%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSD 235
+ + T+ LG G G V K + I A+K I N +K++ +L N ++
Sbjct: 33 DDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCF 92
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
+ V +YG E ++I ME M SLD Y+ +L K I E +LG+IA S++R L
Sbjct: 93 YTVTFYGALFRE--GDVWICMELMD-TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALE 149
Query: 296 YLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERIQG 353
+LH + +IHRD+KP N+L N+ G +K+CDFG+SG V+S+A T G YMAPERI
Sbjct: 150 HLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINP 209
Query: 354 Q----PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
+ Y+V SDVWSLG+T++E+A P++ + P +L ++ +P+L +
Sbjct: 210 ELNQKGYNVKSDVWSLGITMIEMAILRFPYE----SWGTPFQQLKQVVEEPSPQLPADR- 264
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQ 460
+S F F L+K+ +R S ++++HP+ K ++ F++
Sbjct: 265 ----FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVK 311
>Hs21618349 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 347
Score = 150 bits (379), Expect = 4e-36
Identities = 97/291 (33%), Positives = 157/291 (53%), Gaps = 19/291 (6%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSD 235
+ + T+ LG G G V K + I A+K I N +K++ +L N ++
Sbjct: 62 DDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCF 121
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
+ V +YG E ++I ME M SLD Y+ +L K I E +LG+IA S++R L
Sbjct: 122 YTVTFYGALFRE--GDVWICMELMD-TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALE 178
Query: 296 YLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERIQG 353
+LH + +IHRD+KP N+L N+ G +K+CDFG+SG V+S+A T G YMAPERI
Sbjct: 179 HLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINP 238
Query: 354 Q----PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
+ Y+V SDVWSLG+T++E+A P++ + P +L ++ +P+L +
Sbjct: 239 ELNQKGYNVKSDVWSLGITMIEMAILRFPYE----SWGTPFQQLKQVVEEPSPQLPADR- 293
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQ 460
+S F F L+K+ +R S ++++HP+ K ++ F++
Sbjct: 294 ----FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVK 340
>Hs21618347 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 318
Score = 150 bits (379), Expect = 4e-36
Identities = 97/291 (33%), Positives = 157/291 (53%), Gaps = 19/291 (6%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSD 235
+ + T+ LG G G V K + I A+K I N +K++ +L N ++
Sbjct: 33 DDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCF 92
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
+ V +YG E ++I ME M SLD Y+ +L K I E +LG+IA S++R L
Sbjct: 93 YTVTFYGALFRE--GDVWICMELMD-TSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALE 149
Query: 296 YLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERIQG 353
+LH + +IHRD+KP N+L N+ G +K+CDFG+SG V+S+A T G YMAPERI
Sbjct: 150 HLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINP 209
Query: 354 Q----PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE 409
+ Y+V SDVWSLG+T++E+A P++ + P +L ++ +P+L +
Sbjct: 210 ELNQKGYNVKSDVWSLGITMIEMAILRFPYE----SWGTPFQQLKQVVEEPSPQLPADR- 264
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQ 460
+S F F L+K+ +R S ++++HP+ K ++ F++
Sbjct: 265 ----FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVK 311
>Hs21735542 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 462
Score = 149 bits (377), Expect = 7e-36
Identities = 100/275 (36%), Positives = 151/275 (54%), Gaps = 22/275 (8%)
Query: 179 IDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSDFI 237
++ LG +G GT G V K + R + A+K + N K+I +L KS +I
Sbjct: 163 LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYI 222
Query: 238 VRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYL 297
V+ +G F + +FIAME MG + + K + G I E++LGK+ ++++ L+YL
Sbjct: 223 VQCFGTFITN--TDVFIAMELMG-TCAEKLKKRMQ---GPIPERILGKMTVAIVKALYYL 276
Query: 298 HERK-IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA-TTFTGTSYYMAPERIQ--- 352
E+ +IHRD+KP NIL +E GQIK CDFG+SG V+S A T G + YMAPERI
Sbjct: 277 KEKHGVIHRDVKPSNILLDERGQIKFCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPD 336
Query: 353 --GQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQ 410
Y + +DVWSLG++L+E+A G P+ K E+L +L P L
Sbjct: 337 PTKPDYDIRADVWSLGISLVELATGQFPYKNCK-----TDFEVLTKVLQEEPPLL---PG 388
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ +S F+SF+ L KD + RP ++L+H ++
Sbjct: 389 HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI 423
>At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 307
Score = 147 bits (371), Expect = 3e-35
Identities = 92/273 (33%), Positives = 143/273 (51%), Gaps = 20/273 (7%)
Query: 179 IDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIV 238
++ L +LG G+ G V K + +I+ALK++ + +Q+ RE++ + S ++V
Sbjct: 45 VEKLHVLGRGSSGIVYKVHHKTTGEIYALKSVNGDMSPAFTRQLAREMEILRRTDSPYVV 104
Query: 239 RYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
R G+F + I MEYM G +L+S+ G + EK L + +L+GL YLH
Sbjct: 105 RCQGIFEKPIVGEVSILMEYMDGGNLESLR-------GAVTEKQLAGFSRQILKGLSYLH 157
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQ---G 353
KI+HRDIKP N+L N ++K+ DFGVS SL ++ GT YM+PER G
Sbjct: 158 SLKIVHRDIKPANLLLNSRNEVKIADFGVSKIITRSLDYCNSYVGTCAYMSPERFDSAAG 217
Query: 354 QPYSV-TSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGI 412
+ V D+WS G+ +LE+ GH P P LM ++ F + P
Sbjct: 218 ENSDVYAGDIWSFGVMILELFVGHFPLLPQ---GQRPDWATLMCVVCF----GEPPRAPE 270
Query: 413 VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
S F+SF+D L+K+S +R + Q+L HP++
Sbjct: 271 GCSDEFRSFVDCCLRKESSERWTASQLLGHPFL 303
>CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1096
Score = 146 bits (368), Expect = 7e-35
Identities = 100/310 (32%), Positives = 163/310 (52%), Gaps = 38/310 (12%)
Query: 180 DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQF-NKSCKSDFIV 238
+ + ++G GT G V K + +++ A+K + N+ E +I E+ K +
Sbjct: 22 ELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNI--NEDEEDEIKLEINMLKKHSHHRNVA 79
Query: 239 RYYGMFACEETST------IFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
YYG F + S+ +++ ME+ G S+ + K+ +KGG + E+ + I +LR
Sbjct: 80 TYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKN--TKGGSLKEEWIAYICREILR 137
Query: 293 GLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPER 350
GL++LH+ K+IHRDIK QN+L + ++KL DFGVS + ++ TF GT Y+MAPE
Sbjct: 138 GLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEV 197
Query: 351 I-----QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPEL 404
I Y SD+WSLG+T LE+A+GH P +M P+ L LI P+L
Sbjct: 198 IACDESPEATYDSRSDLWSLGITALEMAEGHPPL------CDMHPMRALFLIPRNPPPKL 251
Query: 405 KDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ---------TKKHVNM 455
K + W+K F++F++ L KD RP +L+HP++ Q K+H++
Sbjct: 252 KRNKK----WTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDR 307
Query: 456 KKFIQTCWAD 465
+ ++ AD
Sbjct: 308 NRRVKKDDAD 317
>CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1082
Score = 146 bits (368), Expect = 7e-35
Identities = 100/310 (32%), Positives = 163/310 (52%), Gaps = 38/310 (12%)
Query: 180 DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQF-NKSCKSDFIV 238
+ + ++G GT G V K + +++ A+K + N+ E +I E+ K +
Sbjct: 22 ELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNI--NEDEEDEIKLEINMLKKHSHHRNVA 79
Query: 239 RYYGMFACEETST------IFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
YYG F + S+ +++ ME+ G S+ + K+ +KGG + E+ + I +LR
Sbjct: 80 TYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKN--TKGGSLKEEWIAYICREILR 137
Query: 293 GLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPER 350
GL++LH+ K+IHRDIK QN+L + ++KL DFGVS + ++ TF GT Y+MAPE
Sbjct: 138 GLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEV 197
Query: 351 I-----QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPEL 404
I Y SD+WSLG+T LE+A+GH P +M P+ L LI P+L
Sbjct: 198 IACDESPEATYDSRSDLWSLGITALEMAEGHPPL------CDMHPMRALFLIPRNPPPKL 251
Query: 405 KDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ---------TKKHVNM 455
K + W+K F++F++ L KD RP +L+HP++ Q K+H++
Sbjct: 252 KRNKK----WTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDR 307
Query: 456 KKFIQTCWAD 465
+ ++ AD
Sbjct: 308 NRRVKKDDAD 317
>CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1087
Score = 146 bits (368), Expect = 7e-35
Identities = 100/310 (32%), Positives = 163/310 (52%), Gaps = 38/310 (12%)
Query: 180 DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQF-NKSCKSDFIV 238
+ + ++G GT G V K + +++ A+K + N+ E +I E+ K +
Sbjct: 22 ELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNI--NEDEEDEIKLEINMLKKHSHHRNVA 79
Query: 239 RYYGMFACEETST------IFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
YYG F + S+ +++ ME+ G S+ + K+ +KGG + E+ + I +LR
Sbjct: 80 TYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKN--TKGGSLKEEWIAYICREILR 137
Query: 293 GLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPER 350
GL++LH+ K+IHRDIK QN+L + ++KL DFGVS + ++ TF GT Y+MAPE
Sbjct: 138 GLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEV 197
Query: 351 I-----QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPEL 404
I Y SD+WSLG+T LE+A+GH P +M P+ L LI P+L
Sbjct: 198 IACDESPEATYDSRSDLWSLGITALEMAEGHPPL------CDMHPMRALFLIPRNPPPKL 251
Query: 405 KDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ---------TKKHVNM 455
K + W+K F++F++ L KD RP +L+HP++ Q K+H++
Sbjct: 252 KRNKK----WTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDR 307
Query: 456 KKFIQTCWAD 465
+ ++ AD
Sbjct: 308 NRRVKKDDAD 317
>At3g15220 [T] KOG0201 Serine/threonine protein kinase
Length = 690
Score = 145 bits (367), Expect = 1e-34
Identities = 89/270 (32%), Positives = 147/270 (53%), Gaps = 20/270 (7%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
++G G+ G V K ++ +K A+K I E++ + I +E+ C+ +I YYG
Sbjct: 20 LIGRGSFGDVYKAFDKDLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYITEYYGS 79
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ + + ++I MEYM G S+ LL + E + I +L + YLH I
Sbjct: 80 YLHQ--TKLWIIMEYMAGGSVAD----LLQSNNPLDETSIACITRDLLHAVEYLHNEGKI 133
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERIQ-GQPYSVTS 360
HRDIK NIL +E G +K+ DFGVS + +++ TF GT ++MAPE IQ + Y+ +
Sbjct: 134 HRDIKAANILLSENGDVKVADFGVSAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKA 193
Query: 361 DVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKS 420
D+WSLG+T++E+A+G P A++ P+ +L +I TP DE +S+ K
Sbjct: 194 DIWSLGITVIEMAKGEPPL------ADLHPMRVLFIIPRETPPQLDEH-----FSRQVKE 242
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWMVGQTK 450
F+ LKK +RPS +++++H ++ K
Sbjct: 243 FVSLCLKKAPAERPSAKELIKHRFIKNARK 272
>At1g53165 [T] KOG0201 Serine/threonine protein kinase
Length = 1007
Score = 145 bits (365), Expect = 2e-34
Identities = 89/270 (32%), Positives = 147/270 (53%), Gaps = 20/270 (7%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
++G G+ G V K +K A+K I E++ + I +E+ C+ +I YYG
Sbjct: 347 LIGRGSFGDVYKAFDTELNKDVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYITEYYGS 406
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ + + ++I MEYM G S+ LL G + E + I +L + YLH I
Sbjct: 407 YLHQ--TKLWIIMEYMAGGSVAD----LLQPGNPLDEISIACITRDLLHAVEYLHAEGKI 460
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERIQ-GQPYSVTS 360
HRDIK NIL +E G +K+ DFGVS + +++ TF GT ++MAPE IQ + Y+ +
Sbjct: 461 HRDIKAANILLSENGDVKVADFGVSAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKA 520
Query: 361 DVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKS 420
D+WSLG+T++E+A+G P A++ P+ +L +I +P DE +S+ K
Sbjct: 521 DIWSLGITMIEMAKGEPPL------ADLHPMRVLFIIPRESPPQLDEH-----FSRPLKE 569
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWMVGQTK 450
F+ + LKK +RP+ +++L+H ++ K
Sbjct: 570 FVSFCLKKAPAERPNAKELLKHRFIKNARK 599
>Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 833
Score = 141 bits (355), Expect = 2e-33
Identities = 94/275 (34%), Positives = 148/275 (53%), Gaps = 27/275 (9%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
+ D L LG GT G V K + + + ALK + +E D + +E+ K+C+
Sbjct: 15 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK-MEPDDDVSTLQKEILILKTCRHAN 73
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IV Y+G + + ++I ME+ G SL +Y+ G + E + + VL+GL Y
Sbjct: 74 IVAYHGSYLWLQK--LWICMEFCGAGSLQDIYQVT----GSLSELQISYVCREVLQGLAY 127
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPE----R 350
LH +K IHRDIK NIL N+ G+++L DFG+S + +LA +F GT Y+MAPE
Sbjct: 128 LHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVA 187
Query: 351 IQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTF---TPELKDE 407
++G Y+ D+WSLG+T +E+A+ P ++ P+ +L L+ P LK++
Sbjct: 188 LKG-GYNELCDIWSLGITAIELAELQPPL------FDVHPLRVLFLMTKSGYQPPRLKEK 240
Query: 408 PEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQH 442
+ WS +F +F+ +L K K RPS +ML H
Sbjct: 241 GK----WSAAFHNFIKVTLTKSPKKRPSATKMLSH 271
>At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 836
Score = 140 bits (353), Expect = 4e-33
Identities = 99/310 (31%), Positives = 164/310 (51%), Gaps = 20/310 (6%)
Query: 140 SSTSLVNHGKESEIIEHDRDD-STDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKL 198
SS+S HG+++ ++ ST L I + + + L LG+G+ GSV K +
Sbjct: 210 SSSSSKLHGEDNRKMQQQNSKMSTTSLPDSITREDPT-TKYEFLNELGKGSYGSVYKARD 268
Query: 199 RNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEY 258
S+I A+K I+ E + ++I E++ + C +VRY G + E+ ++I MEY
Sbjct: 269 LKTSEIVAVKVISLTEGEEGYEEIRGEIEMLQQCNHPNVVRYLGSYQGEDY--LWIVMEY 326
Query: 259 MGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIG 318
GG S+ + + E + I L+GL YLH +HRDIK NIL E G
Sbjct: 327 CGGGSVADLMNVTEEA---LEEYQIAYICREALKGLAYLHSIYKVHRDIKGGNILLTEQG 383
Query: 319 QIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGH 376
++KL DFGV+ + +++ TF GT ++MAPE IQ Y DVW+LG++ +E+A+G
Sbjct: 384 EVKLGDFGVAAQLTRTMSKRNTFIGTPHWMAPEVIQENRYDGKVDVWALGVSAIEMAEGL 443
Query: 377 SPFDTDKLAANMPPIELLMLI-LTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPS 435
P +++ P+ +L +I + P L+D+ + WS F F+ L K+ + RP+
Sbjct: 444 PP------RSSVHPMRVLFMISIEPAPMLEDKEK----WSLVFHDFVAKCLTKEPRLRPT 493
Query: 436 PRQMLQHPWM 445
+ML+H ++
Sbjct: 494 AAEMLKHKFV 503
>7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 979
Score = 140 bits (353), Expect = 4e-33
Identities = 98/299 (32%), Positives = 150/299 (49%), Gaps = 31/299 (10%)
Query: 180 DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF-IV 238
+ + ++G GT G V K + ++ A+K + E++ E++I E+ K + I
Sbjct: 33 ELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDE--EEEIKLEINVLKKYSNHRNIA 90
Query: 239 RYYGMFACE----ETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGL 294
YYG F + + +++ MEY G S+ + K +KG + E+ + I +LRGL
Sbjct: 91 TYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKS--TKGQSLKEEWIAYICREILRGL 148
Query: 295 FYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERI- 351
YLH K+IHRDIK QN+L + ++KL DFGVS + ++ TF GT Y+MAPE I
Sbjct: 149 SYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIA 208
Query: 352 ----QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPELKD 406
Y SD+WSLG+T LE+A+ P ++ P+ L LI P LK
Sbjct: 209 CDENPDATYDNRSDLWSLGITALEMAESQPPL------CDLHPMRALFLIPRNSPPRLKS 262
Query: 407 EPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ---TKKHVNMKKFIQTC 462
+ WSK F F+D L KD RP +L+H ++ Q + + +K I C
Sbjct: 263 KK-----WSKKFHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRC 316
>Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 894
Score = 140 bits (352), Expect = 5e-33
Identities = 91/277 (32%), Positives = 149/277 (52%), Gaps = 25/277 (9%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
E + + +G GT G V K + N ++ A+K I +E + +E+ K CK
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIK-LEPGEDFAVVQQEIIMMKDCKHPN 72
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IV Y+G + + ++I ME+ GG SL +Y H+ G + E + ++ L+GL+Y
Sbjct: 73 IVAYFGSYLRRDK--LWICMEFCGGGSLQDIY-HVT---GPLSELQIAYVSRETLQGLYY 126
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERIQGQ 354
LH + +HRDIK NIL + G +KL DFGVS + ++A +F GT Y+MAPE +
Sbjct: 127 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE 186
Query: 355 ---PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFT---PELKDEP 408
Y+ D+W++G+T +E+A+ P ++ P+ L L+ P+LKD+
Sbjct: 187 RKGGYNQLCDLWAVGITAIELAELQPPM------FDLHPMRALFLMTKSNFQPPKLKDK- 239
Query: 409 EQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ WS SF F+ +L K+ K RP+ ++LQHP++
Sbjct: 240 ---MKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 273
>SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase
Length = 471
Score = 139 bits (351), Expect = 7e-33
Identities = 93/264 (35%), Positives = 139/264 (52%), Gaps = 21/264 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
LG G+ G V K + I A+K I I +E+ +C S +++YYG F
Sbjct: 15 LGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSNCNSSNVIQYYGCF 74
Query: 245 ACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIH 304
+ T++I ME+M G S+ L K GR+ E+V+ I VL GL YLH + IH
Sbjct: 75 V--DGYTLWILMEHMDGGSVSG-----LLKMGRLNEQVISIILREVLYGLNYLHGQNKIH 127
Query: 305 RDIKPQNILFNE-IGQIKLCDFGVSGEAVNSLAT--TFTGTSYYMAPERIQGQPYSVTSD 361
RDIK NIL + G +KL DFGV+ + N+ + TF GT ++MAPE IQ Y + +D
Sbjct: 128 RDIKAANILLSSSTGNVKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVIQQTSYGLAAD 187
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSF 421
+WSLG+T +E+A G P A M P+ ++ I P D+ +S +F+ F
Sbjct: 188 IWSLGITAIEMANGIPP------RATMHPMRVIFEIPQSEPPKLDDH-----FSPTFRDF 236
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWM 445
+ L + R S +++LQHP++
Sbjct: 237 VSCCLDLNPNMRWSAKELLQHPFI 260
>7292829 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 492
Score = 139 bits (351), Expect = 7e-33
Identities = 103/288 (35%), Positives = 154/288 (52%), Gaps = 23/288 (7%)
Query: 182 LGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSDFIVRY 240
LG LG GT G+V K + + I A+K + N K+I +L KS +IV+
Sbjct: 200 LGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKC 259
Query: 241 YGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
G F + ++I ME M D + K LSK + E++LGK+ + + L YL ++
Sbjct: 260 LGCFVRDPD--VWICMELMS-MCFDKLLK--LSKKP-VPEQILGKVTVATVNALSYLKDK 313
Query: 301 K-IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATT-FTGTSYYMAPERIQGQ--PY 356
+IHRD+KP NIL +E G IKLCDFG+SG V+S A T G + YMAPERI + Y
Sbjct: 314 HGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKY 373
Query: 357 SVTSDVWSLGLTLLEVAQGHSPFD---TDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
+ +DVWSLG+TL+E+A SP++ TD E+L +L P E G
Sbjct: 374 DIRADVWSLGITLVELATARSPYEGCNTD--------FEVLTKVLDSEPPCLPYGE-GYN 424
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQT 461
+S+ F+ F+ L K+ +DRP ++L P++ V++ + Q+
Sbjct: 425 FSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQS 472
>SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase
Length = 312
Score = 139 bits (349), Expect = 1e-32
Identities = 90/271 (33%), Positives = 144/271 (52%), Gaps = 20/271 (7%)
Query: 178 QIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFI 237
Q L ++G+G+ GSV + + SKI ALK + + + +E+ F S I
Sbjct: 5 QYRDLQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVHI 64
Query: 238 VRYYGMFACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
+YY F + ++I MEY GG LD LL G E+V+ ++ VL L Y
Sbjct: 65 TKYYASFV--DGFRLWITMEYCDGGSCLD-----LLKLSGTFSERVIAEVMRQVLEALVY 117
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFTGTSYYMAPERIQGQ 354
LH + +HRDIK NIL + G +KL DFGVSG E++ F GT ++MAPE ++
Sbjct: 118 LHGQGKMHRDIKAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVVKQT 177
Query: 355 PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVW 414
Y+ +D+WSLG+T E+A G P+ + + P+++L+LI +P + + +
Sbjct: 178 GYNYKADIWSLGITAYELATGEPPY------SGIHPMKVLLLIPKHSPPSLERSK----F 227
Query: 415 SKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
S++F F+ LKK+ KDR + + +H ++
Sbjct: 228 SRAFCDFVSNCLKKNPKDRATAEYLSKHKFI 258
>Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1152
Score = 138 bits (348), Expect = 2e-32
Identities = 100/312 (32%), Positives = 156/312 (49%), Gaps = 34/312 (10%)
Query: 149 KESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALK 208
K+ + EH + D E D W+ +G LG+G G V K + + S + A K
Sbjct: 16 KKKKQYEHVKRDLNPE---DFWEI---------IGELGDGAFGKVYKAQNKETSVLAAAK 63
Query: 209 TIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVY 268
I T + E + E+ SC IV+ F E + ++I +E+ G ++D+V
Sbjct: 64 VIDTKSEEELEDYMV-EIDILASCDHPNIVKLLDAFYYE--NNLWILIEFCAGGAVDAV- 119
Query: 269 KHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVS 328
+L + E + + + L L YLH+ KIIHRD+K NILF G IKL DFGVS
Sbjct: 120 --MLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVS 177
Query: 329 GEAVNSL--ATTFTGTSYYMAPERI-----QGQPYSVTSDVWSLGLTLLEVAQGHSPFDT 381
+ ++ +F GT Y+MAPE + + +PY +DVWSLG+TL+E+A+ P
Sbjct: 178 AKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHH- 236
Query: 382 DKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQ 441
+ P+ +L+ I P +P + WS +FK FL L+K+ R + Q+LQ
Sbjct: 237 -----ELNPMRVLLKIAKSEPPTLAQPSR---WSSNFKDFLKKCLEKNVDARWTTSQLLQ 288
Query: 442 HPWMVGQTKKHV 453
HP++ + K +
Sbjct: 289 HPFVTVDSNKPI 300
>Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1295
Score = 138 bits (347), Expect = 2e-32
Identities = 97/287 (33%), Positives = 148/287 (50%), Gaps = 29/287 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF-IVRYYG 242
++G GT G V K + ++ A+K + E++ E++I +E+ K I YYG
Sbjct: 30 VVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKQEINMLKKYSHHRNIATYYG 87
Query: 243 MFACEET----STIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
F + +++ ME+ G S+ + K+ +KG + E + I +LRGL +LH
Sbjct: 88 AFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN--TKGNALKEDCIAYICREILRGLAHLH 145
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERI----- 351
K+IHRDIK QN+L E ++KL DFGVS + ++ TF GT Y+MAPE I
Sbjct: 146 AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPELKDEPEQ 410
Y SD+WSLG+T +E+A+G P +M P+ L LI P LK +
Sbjct: 206 PDATYDYRSDIWSLGITAIEMAEGAPPL------CDMHPMRALFLIPRNPPPRLKSKK-- 257
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ-TKKHVNMK 456
WSK F F+D L K RP Q+L+ P++ Q T++ V ++
Sbjct: 258 ---WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 301
>HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1165
Score = 137 bits (344), Expect = 4e-32
Identities = 95/278 (34%), Positives = 144/278 (51%), Gaps = 28/278 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF-IVRYYG 242
++G GT G V K + ++ A+K + E++ E++I E+ K I YYG
Sbjct: 30 VVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKLEINMLKKYSHHRNIATYYG 87
Query: 243 MFACEET----STIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
F + +++ ME+ G S+ + K+ +KG + E + I+ +LRGL +LH
Sbjct: 88 AFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN--TKGNTLKEDWIAYISREILRGLAHLH 145
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERI----- 351
+IHRDIK QN+L E ++KL DFGVS + ++ TF GT Y+MAPE I
Sbjct: 146 IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPELKDEPEQ 410
Y SD+WS G+T +E+A+G P +M P+ L LI P LK +
Sbjct: 206 PDATYDYRSDLWSCGITAIEMAEGAPPL------CDMHPMRALFLIPRNPPPRLKSKK-- 257
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
WSK F SF++ L K+ RPS Q+L+HP++ Q
Sbjct: 258 ---WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQ 292
>Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1212
Score = 137 bits (344), Expect = 4e-32
Identities = 95/278 (34%), Positives = 144/278 (51%), Gaps = 28/278 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF-IVRYYG 242
++G GT G V K + ++ A+K + E++ E++I E+ K I YYG
Sbjct: 30 VVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKLEINMLKKYSHHRNIATYYG 87
Query: 243 MFACEET----STIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
F + +++ ME+ G S+ + K+ +KG + E + I+ +LRGL +LH
Sbjct: 88 AFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN--TKGNTLKEDWIAYISREILRGLAHLH 145
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERI----- 351
+IHRDIK QN+L E ++KL DFGVS + ++ TF GT Y+MAPE I
Sbjct: 146 IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPELKDEPEQ 410
Y SD+WS G+T +E+A+G P +M P+ L LI P LK +
Sbjct: 206 PDATYDYRSDLWSCGITAIEMAEGAPPL------CDMHPMRALFLIPRNPPPRLKSKK-- 257
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
WSK F SF++ L K+ RPS Q+L+HP++ Q
Sbjct: 258 ---WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQ 292
>Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1320
Score = 137 bits (344), Expect = 4e-32
Identities = 95/278 (34%), Positives = 144/278 (51%), Gaps = 28/278 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF-IVRYYG 242
++G GT G V K + ++ A+K + E++ E++I E+ K I YYG
Sbjct: 30 VVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKLEINMLKKYSHHRNIATYYG 87
Query: 243 MFACEET----STIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
F + +++ ME+ G S+ + K+ +KG + E + I+ +LRGL +LH
Sbjct: 88 AFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN--TKGNTLKEDWIAYISREILRGLAHLH 145
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERI----- 351
+IHRDIK QN+L E ++KL DFGVS + ++ TF GT Y+MAPE I
Sbjct: 146 IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPELKDEPEQ 410
Y SD+WS G+T +E+A+G P +M P+ L LI P LK +
Sbjct: 206 PDATYDYRSDLWSCGITAIEMAEGAPPL------CDMHPMRALFLIPRNPPPRLKSKK-- 257
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
WSK F SF++ L K+ RPS Q+L+HP++ Q
Sbjct: 258 ---WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQ 292
>Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1166
Score = 137 bits (344), Expect = 4e-32
Identities = 95/278 (34%), Positives = 144/278 (51%), Gaps = 28/278 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF-IVRYYG 242
++G GT G V K + ++ A+K + E++ E++I E+ K I YYG
Sbjct: 30 VVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKLEINMLKKYSHHRNIATYYG 87
Query: 243 MFACEET----STIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
F + +++ ME+ G S+ + K+ +KG + E + I+ +LRGL +LH
Sbjct: 88 AFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN--TKGNTLKEDWIAYISREILRGLAHLH 145
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERI----- 351
+IHRDIK QN+L E ++KL DFGVS + ++ TF GT Y+MAPE I
Sbjct: 146 IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPELKDEPEQ 410
Y SD+WS G+T +E+A+G P +M P+ L LI P LK +
Sbjct: 206 PDATYDYRSDLWSCGITAIEMAEGAPPL------CDMHPMRALFLIPRNPPPRLKSKK-- 257
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
WSK F SF++ L K+ RPS Q+L+HP++ Q
Sbjct: 258 ---WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQ 292
>YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 939
Score = 134 bits (338), Expect = 2e-31
Identities = 106/345 (30%), Positives = 163/345 (46%), Gaps = 26/345 (7%)
Query: 104 INTDHLPTSGSQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTD 163
I+T H P QQ QS + ++ S+P + S S + K+ E E +
Sbjct: 550 ISTAHTP----QQVAQSPKAPAQETVTTPTSKPAQARSLSKELNEKKREERERRKKQLYA 605
Query: 164 ELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIF 223
+L ++I + L +G+G G V + A+K + +E ++ I
Sbjct: 606 KL-NEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQM-NLEKQPKKELII 663
Query: 224 RELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVL 283
E+ K K IV + + + +++ MEYM G SL V H + G+IG
Sbjct: 664 NEILVMKGSKHPNIVNFIDSYVLK--GDLWVIMEYMEGGSLTDVVTHCILTEGQIGA--- 718
Query: 284 GKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGE--AVNSLATTFTG 341
+ L GL +LH + ++HRDIK NIL + G IKL DFG + +N TT G
Sbjct: 719 --VCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVG 776
Query: 342 TSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT-F 400
T Y+MAPE + + Y D+WSLG+ ++E+ +G P+ N P+ L LI T
Sbjct: 777 TPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPY------LNETPLRALYLIATNG 830
Query: 401 TPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
TP+LK EPE S S K FLD+ L + +DR S ++L ++
Sbjct: 831 TPKLK-EPEN---LSSSLKKFLDWCLCVEPEDRASATELLHDEYI 871
>Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 968
Score = 134 bits (338), Expect = 2e-31
Identities = 87/277 (31%), Positives = 145/277 (51%), Gaps = 22/277 (7%)
Query: 176 HEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSD 235
+E + +G LG+G G V K K + + A K I T + E I E++ +C
Sbjct: 33 NEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCDHP 91
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
+IV+ G + + ++I +E+ G ++D++ +L + E + + +L L
Sbjct: 92 YIVKLLGAYYHD--GKLWIMIEFCPGGAVDAI---MLELDRGLTEPQIQVVCRQMLEALN 146
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAP----- 348
+LH ++IIHRD+K N+L G I+L DFGVS + + +L +F GT Y+MAP
Sbjct: 147 FLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMC 206
Query: 349 ERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEP 408
E ++ PY +D+WSLG+TL+E+AQ P + P+ +L+ I P P
Sbjct: 207 ETMKDTPYDYKADIWSLGITLIEMAQIEPPHH------ELNPMRVLLKIAKSDPPTLLTP 260
Query: 409 EQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ WS F+ FL +L K+ + RPS Q+L+HP++
Sbjct: 261 SK---WSVEFRDFLKIALDKNPETRPSAAQLLEHPFV 294
>Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 527
Score = 134 bits (338), Expect = 2e-31
Identities = 88/293 (30%), Positives = 144/293 (49%), Gaps = 24/293 (8%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
++G G V + A+K I + S ++ +E+Q C IV YY
Sbjct: 22 VIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTS 81
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKG----GRIGEKVLGKIAESVLRGLFYLHE 299
F ++ +++ M+ + G S+ + KH+++KG G + E + I VL GL YLH+
Sbjct: 82 FVVKDE--LWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHK 139
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAV-------NSLATTFTGTSYYMAPERI- 351
IHRD+K NIL E G +++ DFGVS N + TF GT +MAPE +
Sbjct: 140 NGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVME 199
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKD----E 407
Q + Y +D+WS G+T +E+A G +P+ PP+++LML L P + +
Sbjct: 200 QVRGYDFKADIWSFGITAIELATGAAPYH------KYPPMKVLMLTLQNDPPSLETGVQD 253
Query: 408 PEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQ 460
E + KSF+ + L+KD + RP+ ++L+H + K +K +Q
Sbjct: 254 KEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQ 306
>CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1228
Score = 134 bits (338), Expect = 2e-31
Identities = 89/310 (28%), Positives = 146/310 (46%), Gaps = 22/310 (7%)
Query: 164 ELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIF 223
+L S I+ + + +G LG+G G V K R K+FA I+ +
Sbjct: 19 KLPSYIYDNVNPRDHWNIIGELGDGAFGKVEKAVSRTDPKLFAASKSIEIQEGEELEDFL 78
Query: 224 RELQFNKSCKSD-FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKV 282
E++ CK ++ Y + E T+ + E+ GG ++D++ L G + E
Sbjct: 79 VEIEILSECKGHPVMLGLYSTYFFENKLTMLL--EFCGGGAVDNIIVEL---GHVLKEDQ 133
Query: 283 LGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFT 340
+ I V L +LH + +IHRD+K NIL + GQ++L DFGVS ++ TF
Sbjct: 134 IRYIGYYVCDALKWLHSQNVIHRDLKAGNILLTQDGQVRLADFGVSAKLKSEREKRDTFI 193
Query: 341 GTSYYMAP-----ERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLM 395
GT Y+MAP E + QPY SD+WS G+TL+E+AQG P +++ + +++
Sbjct: 194 GTPYWMAPEVMACETFKDQPYDCISDIWSFGITLIEMAQGEPPH------SDVSVMRVII 247
Query: 396 LILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNM 455
+ P +P W++SF L L KD ++RP ++ +H W K +
Sbjct: 248 KVQKSEPPTLLQPSH---WTRSFSDILTRCLVKDPRNRPPAAEIFKHQWFQNAPSKRKMI 304
Query: 456 KKFIQTCWAD 465
+ +AD
Sbjct: 305 MDLLAEMYAD 314
>Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 820
Score = 134 bits (337), Expect = 3e-31
Identities = 89/280 (31%), Positives = 146/280 (51%), Gaps = 25/280 (8%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
++ + L +G GT G V K + S++ A+K I ++ + +E+ + C+
Sbjct: 14 DRFELLQRVGAGTYGDVYKARDTVTSELAAVK-IVKLDPGDDISSLQQEITILRECRHPN 72
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
+V Y G + ++I ME+ GG SL +Y G + E+ + + L+GL +
Sbjct: 73 VVAYIGSYL--RNDRLWICMEFCGGGSLQEIYHAT----GPLEERQIAYVCREALKGLHH 126
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERIQGQ 354
LH + IHRDIK N+L G +KL DFGVSGE S+A +F GT Y+MAPE +
Sbjct: 127 LHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE 186
Query: 355 ---PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFT---PELKDEP 408
Y+ DVW+LG+T +E+ + P ++ P+ LML+ + P+L+D+
Sbjct: 187 RKGGYNELCDVWALGITAIELGELQPPL------FHLHPMRALMLMSKSSFQPPKLRDKT 240
Query: 409 EQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
W+++F FL +L K+ K RP+ ++LQHP+ Q
Sbjct: 241 R----WTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
>7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1726
Score = 134 bits (336), Expect = 4e-31
Identities = 87/273 (31%), Positives = 141/273 (50%), Gaps = 22/273 (8%)
Query: 180 DTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVR 239
+ +G LG+G G V K + + K FA + +E++ + E+ K IV
Sbjct: 38 EMVGELGDGAFGKVYKAQHKE-QKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVE 96
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
Y F+ ++ +++ +EY G +LDS+ L + E + + + + GL +LH
Sbjct: 97 LYEAFSIDDK--LWMLIEYCDGGALDSIMVELEKP---LTEPQIAYVCKHMTEGLTFLHR 151
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERI-----Q 352
K+IHRD+K N+L G +KL DFGVS + +++ TF GT Y+MAPE + +
Sbjct: 152 NKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFR 211
Query: 353 GQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGI 412
PY D+WSLG+TL+E+AQ P + M P+ +L+ I P ++P +
Sbjct: 212 DNPYDHKVDIWSLGITLIELAQMEPP------NSEMSPMRVLLKIQKSEPPKLEQPSR-- 263
Query: 413 VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
WSK F FL SL KD + RP+ ++QH ++
Sbjct: 264 -WSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI 295
>HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 819
Score = 133 bits (334), Expect = 6e-31
Identities = 89/280 (31%), Positives = 146/280 (51%), Gaps = 25/280 (8%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
++ + L +G GT G V K + S++ A+K I ++ + +E+ + C+
Sbjct: 13 DRFELLQRVGAGTYGDVYKARDTVTSELAAVK-IVKLDPGDDISSLQQEITILRECRHPN 71
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
+V Y G + ++I ME+ GG SL +Y G + E+ + + L+GL +
Sbjct: 72 VVAYIGSYL--RNDRLWICMEFCGGGSLQEIYHAT----GPLEERQIAYVCRERLKGLHH 125
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERIQGQ 354
LH + IHRDIK N+L G +KL DFGVSGE S+A +F GT Y+MAPE +
Sbjct: 126 LHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVE 185
Query: 355 ---PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFT---PELKDEP 408
Y+ DVW+LG+T +E+ + P ++ P+ LML+ + P+L+D+
Sbjct: 186 RKGGYNELCDVWALGITAIELGELQPPL------FHLHPMRALMLMSKSSFQPPKLRDKT 239
Query: 409 EQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
W+++F FL +L K+ K RP+ ++LQHP+ Q
Sbjct: 240 R----WTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 275
>Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 1315
Score = 132 bits (332), Expect = 1e-30
Identities = 89/274 (32%), Positives = 140/274 (50%), Gaps = 22/274 (8%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSE-KQIFRELQFNKSCKSD 235
E+ L ++GEG+ G V K + + +++ ALK I + E + + RE++ + +
Sbjct: 2 EKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHP 61
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
IV F E + + +Y G +L G++ E + IA ++ L+
Sbjct: 62 NIVHMLDSF--ETDKEVVVVTDYAEGELFQ-----ILEDDGKLPEDQVQAIAAQLVSALY 114
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVS-GEAVNSLA-TTFTGTSYYMAPERIQG 353
YLH +I+HRD+KPQNIL + G IKLCDFG + + N++ T+ GT YM+PE ++
Sbjct: 115 YLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEE 174
Query: 354 QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
+PY T+D+WS+G L E+A G PF + +L+ LI LKD
Sbjct: 175 RPYDHTADLWSVGCILYELAVGTPPFYATSI------FQLVSLI------LKDPVRWPST 222
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVG 447
S FK+FL L KD + R S +L HP++ G
Sbjct: 223 ISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAG 256
>YHR102w [T] KOG0201 Serine/threonine protein kinase
Length = 1080
Score = 132 bits (331), Expect = 1e-30
Identities = 96/284 (33%), Positives = 147/284 (50%), Gaps = 31/284 (10%)
Query: 164 ELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIF 223
E E D+ +K E ++G G G V K +++A+K + + + +
Sbjct: 14 EGEMDVSSLFKRTE------VIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQ 67
Query: 224 RELQFNKSCKS-DFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKV 282
RE+QF S K I RYYG + + ++++I ME+ G SL S L + G+I EK
Sbjct: 68 REIQFLASLKQISNITRYYGSYL--KDTSLWIIMEHCAGGSLRS-----LLRPGKIDEKY 120
Query: 283 LGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA---TTF 339
+G I +L L +H+ +IHRDIK N+L G +KLCDFGV+ + VN + T
Sbjct: 121 IGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQ-VNQTSLRRQTM 179
Query: 340 TGTSYYMAPERI-QGQPYSVTSDVWSLGLTLLEVAQGHSPF-DTDKLAANMPPIELLMLI 397
GT Y+MAPE I +G Y D+WSLG+T E+A G+ P+ D + L A + ++I
Sbjct: 180 AGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRA------MQLII 233
Query: 398 LTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQ 441
+ P L+D +S S K F+ L +D K+R S +L+
Sbjct: 234 KSKPPRLEDRS-----YSTSLKEFIALCLDEDPKERLSADDLLK 272
>CE10328 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 363
Score = 131 bits (330), Expect = 2e-30
Identities = 113/322 (35%), Positives = 158/322 (48%), Gaps = 24/322 (7%)
Query: 127 NLISMYDSEPTTSSS--TSLVNHGKESEIIEHD--RDDSTDELE-SDIWQTYKIHE-QID 180
NL + PT+ S+ TSL +G E + E R ST L+ D Y +
Sbjct: 8 NLRNSMSLRPTSLSTRPTSLSVNGNEKTLPEESVLRSLSTGTLKYPDDEHLYTFSSANLQ 67
Query: 181 TLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQI--FRELQ-FNKSCKSDFI 237
LG +G G G+V K + + K+ A+K I N G +QI RE KS K I
Sbjct: 68 DLGAIGNGNFGTVYKMRHKETGKLIAVKRIRC-NNIGHREQIRLLREHDTIVKSEKGPNI 126
Query: 238 VRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHL-LSKGGRIGEKVLGKIAESVLRGLFY 296
V++YG E +I ME M S+D +YK + + K R+ E V+G I + L Y
Sbjct: 127 VKFYGAIFSE--GDCWICMELMD-ISMDLLYKRVYMVKNSRLNENVVGHITVCTVDALDY 183
Query: 297 LH-ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERI-QG 353
L E KIIHRD+KP NIL + G +KLCDFG+ G+ S A T G Y+APERI
Sbjct: 184 LKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERITSS 243
Query: 354 QPYSVTSDVWSLGLTLLEVAQGHSPF-DTDKLAANMPPIELLMLILTFTPELKDEPEQGI 412
Y V SDVWSLG+TL E+A G P+ + + L + + +++ P +
Sbjct: 244 DKYDVRSDVWSLGITLYEIATGKFPYQEWNSL------FDQIATVVSGDPPILHPDSDDF 297
Query: 413 VWSKSFKSFLDYSLKKDSKDRP 434
+S F++ L KD + RP
Sbjct: 298 HYSLPLVKFINTCLTKDRRHRP 319
>7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 1218
Score = 131 bits (329), Expect = 2e-30
Identities = 88/275 (32%), Positives = 143/275 (52%), Gaps = 21/275 (7%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
++ + + +G GT G V K K +++ A+K I +E + I +E+ + C+
Sbjct: 24 DEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIK-LEPSDDIQIIQQEIIMMRDCRHPN 82
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
I+ YYG + + ++I ME+ GG SL +Y+ G + E + + L+GL Y
Sbjct: 83 IIAYYGSYLRRDK--LWICMEFCGGGSLQDIYQVT----GPLTEVQIAYMCRETLKGLEY 136
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGE--AVNSLATTFTGTSYYMAPERIQGQ 354
LH +HRDIK NIL E G +KL DFGVS + A + +F GT Y+MAPE +
Sbjct: 137 LHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVE 196
Query: 355 ---PYSVTSDVWSLGLTLLEVAQGHSP-FDTDKLAANMPPIELLMLILTFTPELKDEPEQ 410
Y+ D+W+ G+T +E+A+ P FD + A LM F P + ++
Sbjct: 197 RKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRA-----LFLMSKSGFKPPTLNNKDK 251
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
WS +F +F+ +L K+ K RP+ ++LQHP++
Sbjct: 252 ---WSPTFHNFIKTALTKNPKKRPTAERLLQHPFV 283
>Hs4507275 [D] KOG0580 Serine/threonine protein kinase
Length = 403
Score = 130 bits (327), Expect = 4e-30
Identities = 102/378 (26%), Positives = 170/378 (43%), Gaps = 35/378 (9%)
Query: 87 NSGSAMGSL--SNK-----LHGLKINTDHLPTSGSQQSTQSADSMTSNLIS-MYDSEPTT 138
NSG A L SN L K+ + H P +Q A S+ + + +++ +
Sbjct: 40 NSGQAQRVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSK 99
Query: 139 SSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKL 198
S + E E+ +++ + + + W E + LG+G G+V +
Sbjct: 100 QPLPSAPENNPEEELASKQKNEESKKRQ---WAL----EDFEIGRPLGKGKFGNVYLARE 152
Query: 199 RNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAM 256
+ I ALK + A +E G E Q+ RE++ + I+R YG F + + +++ +
Sbjct: 153 KQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYF--HDATRVYLIL 210
Query: 257 EYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNE 316
EY L +VY+ L K + E+ + L Y H +++IHRDIKP+N+L
Sbjct: 211 EYA---PLGTVYREL-QKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGS 266
Query: 317 IGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGH 376
G++K+ DFG S A +S TT GT Y+ PE I+G+ + D+WSLG+ E G
Sbjct: 267 AGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGK 326
Query: 377 SPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSP 436
PF+ + I + TF P+ E + + LK + RP
Sbjct: 327 PPFEANTYQETYKRIS--RVEFTF-PDFVTE---------GARDLISRLLKHNPSQRPML 374
Query: 437 RQMLQHPWMVGQTKKHVN 454
R++L+HPW+ + K N
Sbjct: 375 REVLEHPWITANSSKPSN 392
>HsM4507279 [D] KOG0580 Serine/threonine protein kinase
Length = 402
Score = 129 bits (325), Expect = 7e-30
Identities = 83/272 (30%), Positives = 133/272 (48%), Gaps = 20/272 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYYG 242
LG+G G+V + + I ALK + A +E G E Q+ RE++ + I+R YG
Sbjct: 138 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 197
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F + + +++ +EY L +VY+ L K + E+ + + L Y H +++
Sbjct: 198 YF--HDATRVYLILEYA---PLGTVYREL-QKLSKFDEQRTANLYNRIANALSYCHSKRV 251
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDV 362
IHRDIKP+N+L G++K+ DFG S A +S TT GT Y+ PE I+G+ + D+
Sbjct: 252 IHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDL 311
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFL 422
WSLG+ E G PF+ + I + TF P+ E + +
Sbjct: 312 WSLGVLCYEFLVGKPPFEANTYQETYKRIS--RVEFTF-PDFVTE---------GARDLI 359
Query: 423 DYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVN 454
LK + RP R++L+HPW+ + K N
Sbjct: 360 SRLLKHNPSQRPMLREVLEHPWITANSSKPSN 391
>Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 846
Score = 129 bits (325), Expect = 7e-30
Identities = 91/293 (31%), Positives = 152/293 (51%), Gaps = 31/293 (10%)
Query: 161 STDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEK 220
+ D L + Q Y++ +++ G GT G V K + + ++ A+K I +E
Sbjct: 8 AADILRRNPQQDYELVQRV------GSGTYGDVYKARNVHTGELAAVKIIK-LEPGDDFS 60
Query: 221 QIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGE 280
I +E+ K CK IV Y+G + E ++I MEY GG SL +Y H+ G + E
Sbjct: 61 LIQQEIFMVKECKHCNIVAYFGSYLSREK--LWICMEYCGGGSLQDIY-HVT---GPLSE 114
Query: 281 KVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TT 338
+ + L+GL YLH + +HRDIK NIL + G +KL DFGV+ + ++A +
Sbjct: 115 LQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKS 174
Query: 339 FTGTSYYMAPERI---QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLM 395
F GT Y+MAPE + Y+ D+W++G+T +E+ + P ++ P+ L
Sbjct: 175 FIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPM------FDLHPMRALF 228
Query: 396 LILTFT---PELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
L+ P+LKD+ + WS +F +F+ +L K+ K RP+ ++L H ++
Sbjct: 229 LMSKSNFQPPKLKDKTK----WSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
>At3g06230 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 293
Score = 129 bits (324), Expect = 9e-30
Identities = 88/266 (33%), Positives = 137/266 (51%), Gaps = 36/266 (13%)
Query: 179 IDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIV 238
+D + +LG G GG+V K K + S+I+ALK + + + RE++ + S ++
Sbjct: 53 LDRISVLGSGNGGTVFKVKDKTTSEIYALKKV----KENWDSTSLREIEILRMVNSPYVA 108
Query: 239 RYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
+ + +F + + I M+YM SL+S+ +G + EK L ++ VL G YLH
Sbjct: 109 KCHDIFQ-NPSGEVSILMDYMDLGSLESL------RG--VTEKQLALMSRQVLEGKNYLH 159
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQGQPY 356
E KI+HRDIKP N+L + ++K+ DFGVS V SL +F GT YM+PER+ +
Sbjct: 160 EHKIVHRDIKPANLLRSSKEEVKIADFGVSKIVVRSLNKCNSFVGTFAYMSPERLDSEAD 219
Query: 357 SVT---------SDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDE 407
VT D+WS GLT+LE+ G+ P M P + ++ E
Sbjct: 220 GVTEEDKSNVYAGDIWSFGLTMLEILVGYYP---------MLPDQAAIVCAVCFGEPPKA 270
Query: 408 PEQGIVWSKSFKSFLDYSLKKDSKDR 433
PE+ S KSF+D L+K + +R
Sbjct: 271 PEE---CSDDLKSFMDCCLRKKASER 293
>At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 348
Score = 129 bits (323), Expect = 1e-29
Identities = 90/279 (32%), Positives = 137/279 (48%), Gaps = 25/279 (8%)
Query: 178 QIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFI 237
+++ + +G G GG+V K S+ FALK I D +QI RE++ +S +
Sbjct: 69 ELERVNRIGSGAGGTVYKVIHTPTSRPFALKVIYGNHEDTVRRQICREIEILRSVDHPNV 128
Query: 238 VRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYL 297
V+ + MF + I + +E+M SL+ H+ E+ L ++ +L GL YL
Sbjct: 129 VKCHDMF--DHNGEIQVLLEFMDQGSLEGA--HIWQ------EQELADLSRQILSGLAYL 178
Query: 298 HERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERI---- 351
H R I+HRDIKP N+L N +K+ DFGVS ++ + GT YM+PERI
Sbjct: 179 HRRHIVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDL 238
Query: 352 -QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQ 410
G+ DVWSLG+++LE G PF + L+ I P PE
Sbjct: 239 NHGRYDGYAGDVWSLGVSILEFYLGRFPFAVSRQG---DWASLMCAICMSQP-----PEA 290
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQT 449
S+ F+ F+ L+ D R S +Q+LQHP+++ T
Sbjct: 291 PATASQEFRHFVSCCLQSDPPKRWSAQQLLQHPFILKAT 329
>At1g53570 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 129 bits (323), Expect = 1e-29
Identities = 91/273 (33%), Positives = 137/273 (49%), Gaps = 24/273 (8%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQ-----FNKSCKSDFIVR 239
LG GT G V K+ A+K + I +D + K+ ++L N+ C + IV+
Sbjct: 220 LGSGTFGQVYLGFNSEKGKMCAIKEVKVISDDQTSKECLKQLNQEINLLNQLCHPN-IVQ 278
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
YYG EET ++++ EY+ G S+ LL G E V+ +L GL YLH
Sbjct: 279 YYGSELSEETLSVYL--EYVSGGSIHK----LLKDYGSFTEPVIQNYTRQILAGLAYLHG 332
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN-SLATTFTGTSYYMAPERIQGQ-PYS 357
R +HRDIK NIL + G+IKL DFG++ S +F G+ Y+MAPE + Q Y+
Sbjct: 333 RNTVHRDIKGANILVDPNGEIKLADFGMAKHVTAFSTMLSFKGSPYWMAPEVVMSQNGYT 392
Query: 358 VTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKS 417
D+WSLG T+LE+A P+ + A + I KD PE S
Sbjct: 393 HAVDIWSLGCTILEMATSKPPWSQFEGVAAIFKI----------GNSKDTPEIPDHLSND 442
Query: 418 FKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTK 450
K+F+ L+++ RP+ Q+L+HP++ T+
Sbjct: 443 AKNFIRLCLQRNPTVRPTASQLLEHPFLRNTTR 475
>Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 357
Score = 129 bits (323), Expect = 1e-29
Identities = 90/284 (31%), Positives = 140/284 (48%), Gaps = 22/284 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQI-FRELQFNKSCKSDFIVRYYGM 243
+G+GT G V K + + A+K + + + E + + LQF + + +V++YGM
Sbjct: 33 IGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNILQFLPNHPN--VVKFYGM 90
Query: 244 FACEETST---IFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
F + +++ +E G S+ + K LL G R+ E ++ I L GL +LH
Sbjct: 91 FYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNN 150
Query: 301 KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS--LATTFTGTSYYMAPERI-----QG 353
+IIHRD+K NIL G +KL DFGVS + ++ T GT ++MAPE I
Sbjct: 151 RIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYD 210
Query: 354 QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
Y DVWSLG+T +E+ G P +M P++ L I P PE+
Sbjct: 211 SSYDARCDVWSLGITAIELGDGDPPL------FDMHPVKTLFKIPRNPPPTLLHPEK--- 261
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKK 457
W + F F+ L KD + RPS +L HP++ G K + ++K
Sbjct: 262 WCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQK 305
>CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 829
Score = 128 bits (322), Expect = 2e-29
Identities = 90/292 (30%), Positives = 146/292 (49%), Gaps = 26/292 (8%)
Query: 165 LESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFR 224
+ +D+ + + + L +G GT G V K + + A+K + +E + I +
Sbjct: 1 MSADVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDSLAAVKVVK-LEAGDNFAVIQQ 59
Query: 225 ELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLG 284
E+ + C I+ Y+G + + ++I MEY GG SL +Y HL G + E +
Sbjct: 60 EIMVIRECSHPNIIAYFGSYIRRDR--LWIVMEYCGGGSLQDIY-HLT---GPLSELQIA 113
Query: 285 KIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGT 342
+ LRGL YLH IHRDIK NIL + G +KL DFGV+ + ++ +F GT
Sbjct: 114 FVCRETLRGLNYLHNMGKIHRDIKGANILLSSSGDVKLADFGVAAQITATIGKRKSFIGT 173
Query: 343 SYYMAPERI---QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT 399
Y+MAPE + Y + DVW+ G+T +E+ + P ++ P+++L L+
Sbjct: 174 PYWMAPEVACVEKRGGYGMQCDVWATGITAIELGECQPPL------FDLHPMQVLYLMTK 227
Query: 400 F---TPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQML-QHPWMVG 447
P LKD+ W+ F F+ L K+ K RPSP ++L HP+++G
Sbjct: 228 SGYKPPHLKDKHR----WTPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFVLG 275
>At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 366
Score = 128 bits (322), Expect = 2e-29
Identities = 85/269 (31%), Positives = 133/269 (48%), Gaps = 25/269 (9%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+G G GG+V K R S+++ALK I + +QI RE++ + +V+ + MF
Sbjct: 85 IGSGAGGTVYKVIHRPSSRLYALKVIYGNHEETVRRQICREIEILRDVNHPNVVKCHEMF 144
Query: 245 ACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIH 304
++ I + +E+M SL+ + E+ L ++ +L GL YLH R I+H
Sbjct: 145 --DQNGEIQVLLEFMDKGSLEGAHVWK--------EQQLADLSRQILSGLAYLHSRHIVH 194
Query: 305 RDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERI-----QGQPYS 357
RDIKP N+L N +K+ DFGVS ++ + GT YM+PERI QG+
Sbjct: 195 RDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERINTDLNQGKYDG 254
Query: 358 VTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKS 417
D+WSLG+++LE G PF + L+ I P PE S
Sbjct: 255 YAGDIWSLGVSILEFYLGRFPFPVSRQG---DWASLMCAICMSQP-----PEAPATASPE 306
Query: 418 FKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
F+ F+ L+++ R S Q+LQHP+++
Sbjct: 307 FRHFISCCLQREPGKRRSAMQLLQHPFIL 335
>Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 128 bits (321), Expect = 2e-29
Identities = 83/274 (30%), Positives = 140/274 (50%), Gaps = 24/274 (8%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
++G G V + + A+K I + S ++ +E+Q C +V YY
Sbjct: 70 VIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTS 129
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKG----GRIGEKVLGKIAESVLRGLFYLHE 299
F ++ +++ M+ + G S+ + K+++++G G + E ++ I + VL GL YLH
Sbjct: 130 FVVKDE--LWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHR 187
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVS------GEAV-NSLATTFTGTSYYMAPERI- 351
IHRD+K NIL E G +++ DFGVS G+ N + TF GT +MAPE +
Sbjct: 188 NGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVME 247
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPEL----KDE 407
Q + Y +D+WS G+T +E+A G +P+ PP+++LML L P ++
Sbjct: 248 QVRGYDFKADMWSFGITAIELATGAAPYH------KYPPMKVLMLTLQNDPPTLETGVED 301
Query: 408 PEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQ 441
E + KSF+ L L+KD RP+ ++L+
Sbjct: 302 KEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLK 335
>Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 127 bits (320), Expect = 3e-29
Identities = 87/284 (30%), Positives = 140/284 (48%), Gaps = 22/284 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSD-FIVRYYGM 243
+G+GT G V K + + A+K + I + +++I E K+ +VR+YG+
Sbjct: 27 IGKGTYGKVFKVLNKKNGQKAAVKILDPIHD--IDEEIEAEYNILKALSDHPNVVRFYGI 84
Query: 244 FACEET---STIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
+ ++ +++ +E G S+ + K L +G R+ E ++ I L GL +LH
Sbjct: 85 YFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNN 144
Query: 301 KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS--LATTFTGTSYYMAPERIQGQ---- 354
K IHRD+K NIL G +KL DFGVS + ++ T GT ++MAPE I +
Sbjct: 145 KTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLD 204
Query: 355 -PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
Y D WSLG+T +E+ G P A++ P+ L I P +PE +
Sbjct: 205 TTYDARCDTWSLGITAIELGDGDPPL------ADLHPMRALFKIPRNPPPKLRQPE---L 255
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKK 457
WS F F+ L KD + RP+ ++LQH ++ K V ++K
Sbjct: 256 WSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQK 299
>Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 127 bits (320), Expect = 3e-29
Identities = 87/284 (30%), Positives = 140/284 (48%), Gaps = 22/284 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSD-FIVRYYGM 243
+G+GT G V K + + A+K + I + +++I E K+ +VR+YG+
Sbjct: 27 IGKGTYGKVFKVLNKKNGQKAAVKILDPIHD--IDEEIEAEYNILKALSDHPNVVRFYGI 84
Query: 244 FACEET---STIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
+ ++ +++ +E G S+ + K L +G R+ E ++ I L GL +LH
Sbjct: 85 YFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNN 144
Query: 301 KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS--LATTFTGTSYYMAPERIQGQ---- 354
K IHRD+K NIL G +KL DFGVS + ++ T GT ++MAPE I +
Sbjct: 145 KTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLD 204
Query: 355 -PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
Y D WSLG+T +E+ G P A++ P+ L I P +PE +
Sbjct: 205 TTYDARCDTWSLGITAIELGDGDPPL------ADLHPMRALFKIPRNPPPKLRQPE---L 255
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKK 457
WS F F+ L KD + RP+ ++LQH ++ K V ++K
Sbjct: 256 WSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQK 299
>CE04724 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 505
Score = 126 bits (317), Expect = 6e-29
Identities = 91/287 (31%), Positives = 148/287 (50%), Gaps = 25/287 (8%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQ-FNKSCKSDFIVRYYGM 243
+G G+ G+VTKC+ + S I A+KT+ N +I +L S +IVR +G
Sbjct: 78 IGHGSCGTVTKCRYK--SVIMAVKTMPRTSNSYEMSRILMDLDVICLSFDCPYIVRCFGY 135
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER-KI 302
F + + ME M LD + L+ I E+++GK++ S+++ L YL + +I
Sbjct: 136 FITN--FDVRVCMECMA-TCLDRL---LIRIKQPIPERIIGKLSVSIIKALHYLKTKHQI 189
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA-TTFTGTSYYMAPERIQG---QPYSV 358
+HRD+KP NIL + G IKLCDFG++G + S A + G YM PER+ Y +
Sbjct: 190 MHRDVKPSNILLDWSGVIKLCDFGIAGRLIESRAHSKQAGCPLYMGPERLDPNNFDSYDI 249
Query: 359 TSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSF 418
SDVWS G+TL+E+A G P+ + +++ IL P D + +S F
Sbjct: 250 RSDVWSFGVTLVELATGQYPYAGTE-------FDMMSKILNDEPPRLDPAK----FSPDF 298
Query: 419 KSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFIQTCWAD 465
++ L++D RP+ +LQHP++V K +++++ D
Sbjct: 299 CQLVESCLQRDPTMRPNYDMLLQHPFVVHHEKIETDVEEWFADVMGD 345
>YDR523c [T] KOG0201 Serine/threonine protein kinase
Length = 490
Score = 125 bits (315), Expect = 1e-28
Identities = 92/261 (35%), Positives = 131/261 (49%), Gaps = 22/261 (8%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+G G G V K R +I A+K + +D + + +E+ F KS I Y
Sbjct: 24 IGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATM 83
Query: 245 ACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIH 304
E +++I MEY GG S + K G + E+ + I V GL YLHE++ IH
Sbjct: 84 L--EDVSMWIVMEYCGGGSCSDLLKRSYVNG--LPEEKVSFIIHEVTLGLKYLHEQRKIH 139
Query: 305 RDIKPQNILFNEIGQIKLCDFGVSGEAVNSL-ATTFTGTSYYMAPERI--QGQPYSVTSD 361
RDIK NIL NE G +KL DFGVSG ++L TF GT Y+MAPE + + Y+ +D
Sbjct: 140 RDIKAANILLNEEGMVKLGDFGVSGHIRSTLKRDTFVGTPYWMAPEVVCCEVDGYNEKAD 199
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELL--MLILTFTPELKDEPEQGIVWSKSFK 419
+WSLG+T E+ +G +PP+ M ++T P+ K QG +S + K
Sbjct: 200 IWSLGITTYELLKG------------LPPLSKYDPMKVMTNLPKRKPPKLQG-PFSDAAK 246
Query: 420 SFLDYSLKKDSKDRPSPRQML 440
F+ L K DRPS +L
Sbjct: 247 DFVAGCLVKTPADRPSAYNLL 267
>SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 658
Score = 125 bits (315), Expect = 1e-28
Identities = 87/263 (33%), Positives = 128/263 (48%), Gaps = 19/263 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+G+G G V + + A+K + I ++ I E+ KS IV + F
Sbjct: 392 IGQGASGDVYSARQVGTNLSVAIKKM-NINQQPKKEFIVNEILVMKSHHHKNIVNFIDTF 450
Query: 245 ACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIH 304
+ S +++ MEYM G SL V + + E + I + L GL +LHE I+H
Sbjct: 451 FYK--SELWMVMEYMRGGSLTEVVTN-----NTLSEGQIAAICKETLEGLQHLHENGIVH 503
Query: 305 RDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERIQGQPYSVTSDV 362
RDIK NIL + G IKL DFG + +++ TT GT Y+MAPE + + Y DV
Sbjct: 504 RDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDV 563
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFL 422
WSLG+ +E+ +G P+ N P+ L LI T PE + S F FL
Sbjct: 564 WSLGIMAIEMVEGEPPY------LNENPLRALYLIATIGTPKISRPE---LLSSVFHDFL 614
Query: 423 DYSLKKDSKDRPSPRQMLQHPWM 445
SL + K RPS ++L+HP++
Sbjct: 615 SKSLTVNPKQRPSSGELLRHPFL 637
>Hs19923464 [T] KOG0577 Serine/threonine protein kinase
Length = 898
Score = 125 bits (314), Expect = 1e-28
Identities = 89/268 (33%), Positives = 141/268 (52%), Gaps = 27/268 (10%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEK--QIFRELQFNKSCKSDFIVRYYG 242
+G G+ G+V + +++ A+K ++ EK I +E++F + K + Y G
Sbjct: 30 IGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKG 89
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
+ E T+ ++ MEY G + D + H + E + I L GL YLH +
Sbjct: 90 CYLKEHTA--WLVMEYCLGSASDLLEVHKKP----LQEVEIAAITHGALHGLAYLHSHAL 143
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERI----QGQPYSV 358
IHRDIK NIL E GQ+KL DFG + A S A +F GT Y+MAPE I +GQ Y
Sbjct: 144 IHRDIKAGNILLTEPGQVKLADFGSASMA--SPANSFVGTPYWMAPEVILAMDEGQ-YDG 200
Query: 359 TSDVWSLGLTLLEVAQGHSP-FDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKS 417
D+WSLG+T +E+A+ P F+ + ++A L + +P L Q W+ S
Sbjct: 201 KVDIWSLGITCIELAERKPPLFNMNAMSA------LYHIAQNDSPTL-----QSNEWTDS 249
Query: 418 FKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
F+ F+DY L+K ++RP+ ++L+H ++
Sbjct: 250 FRRFVDYCLQKIPQERPTSAELLRHDFV 277
>CE29622 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 371
Score = 125 bits (313), Expect = 2e-28
Identities = 106/309 (34%), Positives = 158/309 (50%), Gaps = 33/309 (10%)
Query: 150 ESEIIEHDRDDSTDELESDIWQTY------KIHE----QIDTLGILGEGTGGSVTKCKLR 199
E ++ D +S D ++ + T +IHE + L +LG G+ G V K R
Sbjct: 32 EPDLTNEDNMNSLDYVKKYLSNTLVLPPNDRIHEFERDHLQELELLGNGSFGVVRKMLHR 91
Query: 200 NGSKIFALKTIATIEN---DGSEKQIFR---ELQFNKSCKS-DFIVRYYGMFACEETSTI 252
+ A+K I+ I N D K + R E++ K+ + D IVRYYG+ E +
Sbjct: 92 PSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVA-- 149
Query: 253 FIAMEYMGGRSLDSVYK--HLLSKGGRIGEKVLGKIAESVLRGLFYLHE-RKIIHRDIKP 309
++ ME M SLD +Y H + K I E++LG +A + +R L +L IIHRDIKP
Sbjct: 150 WMCMELMD-LSLDKLYMIAHDIQKV-EIPEQILGAVAVATIRALEHLKTTHHIIHRDIKP 207
Query: 310 QNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERI--QGQPYSVTSDVWSLG 366
NIL + G +KLCDFG+ G NS+A + G YMAPER+ G Y + S+VWSLG
Sbjct: 208 SNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERLAPNGDGYDIKSEVWSLG 267
Query: 367 LTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSL 426
+T++EVA G P+D + P ++ + +++ P + D + S S K F+
Sbjct: 268 ITMVEVANGKYPYDG---FMDAPILDQVRMVVYGDPPILDSDHE---VSMSMKRFIALCT 321
Query: 427 KKDSKDRPS 435
KD R S
Sbjct: 322 IKDRNLRAS 330
>7299536 [D] KOG0580 Serine/threonine protein kinase
Length = 411
Score = 124 bits (312), Expect = 2e-28
Identities = 91/323 (28%), Positives = 151/323 (46%), Gaps = 20/323 (6%)
Query: 130 SMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGT 189
S+ +PT +SS S G S E ++ T+ +T++++ D +LG G
Sbjct: 107 SLSKQKPTAASSESSKELGAASSSAEKEKT-KTETQPQKPKKTWELNN-FDIGRLLGRGK 164
Query: 190 GGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACE 247
G+V + + + ALK + I E Q+ RE++ + I+R Y F
Sbjct: 165 FGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYF--H 222
Query: 248 ETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDI 307
+ I++ +EY +L + + K R E+ +++ L YLHER IIHRDI
Sbjct: 223 DDVRIYLILEYAPQGTLFNALQAQPMK--RFDERQSATYIQALCSALLYLHERDIIHRDI 280
Query: 308 KPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGL 367
KP+N+L G +K+ DFG S NS+ T GT Y+ PE +QG+P++ D+WSLG+
Sbjct: 281 KPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGV 340
Query: 368 TLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLK 427
E+ GH+PF + T+ LK + + SK+ + L
Sbjct: 341 LCFELLVGHAPFYSKNYDE------------TYKKILKVDYKLPEHISKAASHLISKLLV 388
Query: 428 KDSKDRPSPRQMLQHPWMVGQTK 450
+ + R Q++ HPW++ T+
Sbjct: 389 LNPQHRLPLDQVMVHPWILAHTQ 411
>CE16527 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 359
Score = 124 bits (311), Expect = 3e-28
Identities = 101/343 (29%), Positives = 164/343 (47%), Gaps = 50/343 (14%)
Query: 122 DSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDT 181
+S++SN S+ + P S ST ++ ++ + + H +
Sbjct: 25 ESLSSNDGSVAEENPLRSMSTGILKFPDDAHLYPFN------------------HTNLRH 66
Query: 182 LGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFN-KSCKSDFIVRY 240
L +G G G+V K + ++ A+K I N + ++ +E + KS IV++
Sbjct: 67 LSQVGAGYYGTVHKMQHNESGRLIAVKKIR-YNNICDQTRLLKEHDTHMKSENVPNIVKF 125
Query: 241 YGMFACEETSTIFIAMEYMGGRSLDSVYKHLLS-KGGRIGEKVLGKIAESVLRGLFYLHE 299
+G AC +I ME M S+D +YK + S K R+ E ++G I ++ L YL +
Sbjct: 126 FG--ACFSEGDCWICMELMD-ISIDFLYKRVYSVKKSRLNENIIGHITVCIVDALDYL-K 181
Query: 300 RKI--IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF-TGTSYYMAPERIQG-QP 355
RK+ IHRD+KP NIL N G +KLCDFG+ G+ V S A T G Y+APERI+
Sbjct: 182 RKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERIENMDK 241
Query: 356 YSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWS 415
Y + SDVWSLG+TL E+A G P+ +E + +++ + + + ++
Sbjct: 242 YDIRSDVWSLGITLYEIATGVYPY-----RGWSNQMEHIEIVVNGDSPILLQNMHNLHYT 296
Query: 416 KSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKF 458
F++ L+K+ DRP K+VN+K F
Sbjct: 297 DPLCRFINTCLRKNKDDRP----------------KYVNLKTF 323
>SPCC320.12c [D] KOG0580 Serine/threonine protein kinase
Length = 384
Score = 124 bits (310), Expect = 4e-28
Identities = 90/266 (33%), Positives = 135/266 (49%), Gaps = 23/266 (8%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGS--EKQIFRELQFNKSCKSDFIVRYYG 242
LG+G G V K + I ALKT+ E S EKQ+ RE++ + + I+R YG
Sbjct: 124 LGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKNILRLYG 183
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F E+ I++ +E+ G L Y+HL + R E+V K + L YLH++ +
Sbjct: 184 HFHDEKR--IYLILEFAGRGEL---YQHL-RRAKRFSEEVASKYIFQMANALSYLHKKHV 237
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDV 362
IHRDIKP+NIL G+IKL DFG S A ++ TT GT Y+ PE ++G+ ++ D+
Sbjct: 238 IHRDIKPENILLGIDGEIKLSDFGWSVHAPSNRRTTLCGTLDYLPPEMVEGKEHTEKVDL 297
Query: 363 WSLGLTLLEVAQGHSPF-DTDKLAANMPPIELLML-ILTFTPELKDEPEQGIVWSKSFKS 420
WSLG+ E G PF D +A I + L I +F P +
Sbjct: 298 WSLGVLTYEFLVGAPPFEDMSGHSATYKRIAKVDLKIPSFVP-------------PDARD 344
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWMV 446
+ L+ + + R S Q+++HPW+V
Sbjct: 345 LISRLLQHNPEKRMSLEQVMRHPWIV 370
>Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 525
Score = 123 bits (309), Expect = 5e-28
Identities = 84/265 (31%), Positives = 139/265 (51%), Gaps = 22/265 (8%)
Query: 185 LGEGTGGSV-TKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
+G+G G+V T + G ++ A+K I ++ ++ I E+ K K+ IV +
Sbjct: 255 IGQGASGTVFTATDVALGQEV-AIKQI-NLQKQPKKELIINEILVMKELKNPNIVNFLDS 312
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ + +F+ MEY+ G SL V +++ + E + + L+ L +LH ++I
Sbjct: 313 YLVGDE--LFVVMEYLAGGSLTDV----VTETACMDEAQIAAVCRECLQALEFLHANQVI 366
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAV--NSLATTFTGTSYYMAPERIQGQPYSVTSD 361
HRDIK N+L G +KL DFG + S +T GT Y+MAPE + + Y D
Sbjct: 367 HRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 426
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT-FTPELKDEPEQGIVWSKSFKS 420
+WSLG+ +E+ +G P+ N P+ L LI T TPEL++ PE+ S F+
Sbjct: 427 IWSLGIMAIEMVEGEPPY------LNENPLRALYLIATNGTPELQN-PEK---LSPIFRD 476
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWM 445
FL+ L+ D + R S +++LQHP++
Sbjct: 477 FLNRCLEMDVEKRGSAKELLQHPFL 501
>Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 591
Score = 122 bits (307), Expect = 9e-28
Identities = 77/270 (28%), Positives = 136/270 (49%), Gaps = 21/270 (7%)
Query: 179 IDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIV 238
+D +GEG+ G V +R+ K+ A+K + + + +F E+ + + + +V
Sbjct: 321 LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKM-DLRKQQRRELLFNEVVIMRDYQHENVV 379
Query: 239 RYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
Y + + +++ ME++ G +L + H R+ E+ + + +VL+ L LH
Sbjct: 380 EMYNSYLVGDE--LWVVMEFLEGGALTDIVTHT-----RMNEEQIAAVCLAVLQALSVLH 432
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQGQPY 356
+ +IHRDIK +IL G++KL DFG + + + GT Y+MAPE I PY
Sbjct: 433 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPY 492
Query: 357 SVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLIL-TFTPELKDEPEQGIVWS 415
D+WSLG+ ++E+ G P+ N PP++ + +I P LK+ + S
Sbjct: 493 GPEVDIWSLGIMVIEMVDGEPPY------FNEPPLKAMKMIRDNLPPRLKNLHKV----S 542
Query: 416 KSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
S K FLD L +D R + ++L+HP++
Sbjct: 543 PSLKGFLDRLLVRDPAQRATAAELLKHPFL 572
>Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1191
Score = 122 bits (307), Expect = 9e-28
Identities = 79/210 (37%), Positives = 113/210 (53%), Gaps = 22/210 (10%)
Query: 256 MEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFN 315
ME+ G S+ + K+ +KG + E + I +LRGL +LH K+IHRDIK QN+L
Sbjct: 1 MEFCGAGSVTDLVKN--TKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLT 58
Query: 316 EIGQIKLCDFGVSGEAVNSLA--TTFTGTSYYMAPERI-----QGQPYSVTSDVWSLGLT 368
E ++KL DFGVS + ++ TF GT Y+MAPE I Y SD+WSLG+T
Sbjct: 59 ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGIT 118
Query: 369 LLEVAQGHSPFDTDKLAANMPPIELLMLI-LTFTPELKDEPEQGIVWSKSFKSFLDYSLK 427
+E+A+G P +M P+ L LI P LK + WSK F F+D L
Sbjct: 119 AIEMAEGAPPL------CDMHPMRALFLIPRNPPPRLKSKK-----WSKKFIDFIDTCLI 167
Query: 428 KDSKDRPSPRQMLQHPWMVGQ-TKKHVNMK 456
K RP Q+L+ P++ Q T++ V ++
Sbjct: 168 KTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 197
>At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 561
Score = 122 bits (306), Expect = 1e-27
Identities = 89/279 (31%), Positives = 138/279 (48%), Gaps = 25/279 (8%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSC 232
YK++E+I G+G +V + + + A+K + + + I RE+Q
Sbjct: 16 YKLYEEI------GDGVSATVHRALCIPLNVVVAIKVLDLEKCNNDLDGIRREVQTMSLI 69
Query: 233 KSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
+++ + F +++ M YM G S + K G E V+ + L+
Sbjct: 70 NHPNVLQAHCSFTTGHQ--LWVVMPYMAGGSCLHIIKSSYPDG--FEEPVIATLLRETLK 125
Query: 293 GLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVS------GEAVNSLATTFTGTSYYM 346
L YLH IHRD+K NIL + G +KL DFGVS G+ S TF GT +M
Sbjct: 126 ALVYLHAHGHIHRDVKAGNILLDSNGAVKLADFGVSACMFDTGDRQRS-RNTFVGTPCWM 184
Query: 347 APERIQG-QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELK 405
APE +Q Y +DVWS G+T LE+A GH+PF + PP+++L++ L P
Sbjct: 185 APEVMQQLHGYDFKADVWSFGITALELAHGHAPF------SKYPPMKVLLMTLQNAPPGL 238
Query: 406 DEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPW 444
D E+ +SK+FK + L KD K RP+ ++L+HP+
Sbjct: 239 DY-ERDKRFSKAFKEMVGTCLVKDPKKRPTSEKLLKHPF 276
>At2g45490 [D] KOG0580 Serine/threonine protein kinase
Length = 288
Score = 122 bits (305), Expect = 1e-27
Identities = 81/264 (30%), Positives = 126/264 (47%), Gaps = 19/264 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYYG 242
LG+G G V + I ALK I IE Q+ RE++ S + I+R +G
Sbjct: 28 LGKGKFGRVYLAREAKSKYIVALKVIFKEQIEKYKIHHQLRREMEIQTSLRHPNILRLFG 87
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F + IF+ +EY G L V K + G + E+ S+ + L Y H + +
Sbjct: 88 WF--HDNERIFLILEYAHGGELYGVLK----QNGHLTEQQAATYIASLSQALAYCHGKCV 141
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDV 362
IHRDIKP+N+L + G++K+ DFG S ++ N T GT Y+APE ++ + + D
Sbjct: 142 IHRDIKPENLLLDHEGRLKIADFGWSVQSSNK-RKTMCGTLDYLAPEMVENRDHDYAVDN 200
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFL 422
W+LG+ E G+ PF+ + I + L TP + +E K+ +
Sbjct: 201 WTLGILCYEFLYGNPPFEAESQKDTFKRILKIDLSFPLTPNVSEEA----------KNLI 250
Query: 423 DYSLKKDSKDRPSPRQMLQHPWMV 446
L KD R S +++QHPW+V
Sbjct: 251 SQLLVKDPSKRLSIEKIMQHPWIV 274
>Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 544
Score = 121 bits (303), Expect = 3e-27
Identities = 84/265 (31%), Positives = 135/265 (50%), Gaps = 23/265 (8%)
Query: 185 LGEGTGGSV-TKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
+G+G G+V T + G ++ A+K + ++ ++ I E+ + K+ IV Y
Sbjct: 274 IGQGASGTVYTALDIATGQEV-AIKQM-NLQQQPKKELIINEILVMRENKNPNIVNYLDS 331
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ + +++ MEY+ G SL V G+I + L+ L +LH ++I
Sbjct: 332 YLVGDE--LWVVMEYLAGGSLTDVVTETCMDEGQIAA-----VCRECLQALDFLHSNQVI 384
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAV--NSLATTFTGTSYYMAPERIQGQPYSVTSD 361
HRDIK NIL G +KL DFG + S +T GT Y+MAPE + + Y D
Sbjct: 385 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 444
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT-FTPELKDEPEQGIVWSKSFKS 420
+WSLG+ +E+ +G P+ N P+ L LI T TPEL++ PE+ S F+
Sbjct: 445 IWSLGIMAIEMVEGEPPY------LNENPLRALYLIATNGTPELQN-PER---LSAVFRD 494
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWM 445
FL+ L+ D R S +++LQHP++
Sbjct: 495 FLNRCLEMDVDRRGSAKELLQHPFL 519
>SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1062
Score = 120 bits (300), Expect = 6e-27
Identities = 90/271 (33%), Positives = 144/271 (52%), Gaps = 25/271 (9%)
Query: 181 TLG-ILGEGTGGSVTK-CKLRNGSKIFALKTIATIENDGSEKQIFR-ELQFNKSCKSDFI 237
TLG LG+G G+V + ++NG + A+K + + S+ + + E+ K+ I
Sbjct: 10 TLGDCLGKGAFGAVYRGLNIKNGETV-AVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNI 68
Query: 238 VRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYL 297
V+Y G + + ++ I +EY SL S+ K+ G+I E ++ VL+GL YL
Sbjct: 69 VKYRGSY--QTNDSLCIILEYCENGSLRSICKNF----GKIPENLVALYTFQVLQGLLYL 122
Query: 298 HERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLAT-TFTGTSYYMAPERIQGQPY 356
H + +IHRDIK NIL + G IKL DFGV+ + +N+L + G+ Y+MAPE I+
Sbjct: 123 HNQGVIHRDIKGANILTTKDGTIKLADFGVATK-INALEDHSVVGSPYWMAPEVIELVGA 181
Query: 357 SVTSDVWSLGLTLLEVAQGHSP-FDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWS 415
+ SD+WS+G T++E+ G+ P +D D P L ++ P L S
Sbjct: 182 TTASDIWSVGCTVIELLDGNPPYYDLD------PTSALFRMVKDEHPPLPSN------IS 229
Query: 416 KSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
+ KSFL +KD R R++L+HPW++
Sbjct: 230 SAAKSFLMQCFQKDPNLRIKTRKLLKHPWVI 260
>Hs7706401 [T] KOG0577 Serine/threonine protein kinase
Length = 1235
Score = 119 bits (299), Expect = 7e-27
Identities = 93/314 (29%), Positives = 160/314 (50%), Gaps = 40/314 (12%)
Query: 149 KESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALK 208
K+ ++ E D ++L SD+ + +G G+ G+V + S++ A+K
Sbjct: 11 KDPDVAELFFKDDPEKLFSDLRE-------------IGHGSFGAVYFARDVRNSEVVAIK 57
Query: 209 TIATIENDGSEK--QIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDS 266
++ +EK I +E++F + + ++Y G + E T+ ++ MEY G + D
Sbjct: 58 KMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTA--WLVMEYCLGSASDL 115
Query: 267 VYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFG 326
+ H + E + + L+GL YLH +IHRD+K NIL +E G +KL DFG
Sbjct: 116 LEVHKKP----LQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
Query: 327 VSGEAVNSLATTFTGTSYYMAPERI----QGQPYSVTSDVWSLGLTLLEVAQGHSP-FDT 381
++ + A +F GT Y+MAPE I +GQ Y DVWSLG+T +E+A+ P F+
Sbjct: 172 --SASIMAPANSFVGTPYWMAPEVILAMDEGQ-YDGKVDVWSLGITCIELAERKPPLFNM 228
Query: 382 DKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQ 441
+ ++A L + +P L Q WS+ F++F+D L+K +DRP+ +L+
Sbjct: 229 NAMSA------LYHIAQNESPVL-----QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLK 277
Query: 442 HPWMVGQTKKHVNM 455
H +++ + V M
Sbjct: 278 HRFVLRERPPTVIM 291
>Hs4759208 [T] KOG0577 Serine/threonine protein kinase
Length = 1049
Score = 119 bits (299), Expect = 7e-27
Identities = 93/314 (29%), Positives = 160/314 (50%), Gaps = 40/314 (12%)
Query: 149 KESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALK 208
K+ ++ E D ++L SD+ + +G G+ G+V + S++ A+K
Sbjct: 11 KDPDVAELFFKDDPEKLFSDLRE-------------IGHGSFGAVYFARDVRNSEVVAIK 57
Query: 209 TIATIENDGSEK--QIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDS 266
++ +EK I +E++F + + ++Y G + E T+ ++ MEY G + D
Sbjct: 58 KMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTA--WLVMEYCLGSASDL 115
Query: 267 VYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFG 326
+ H + E + + L+GL YLH +IHRD+K NIL +E G +KL DFG
Sbjct: 116 LEVHKKP----LQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFG 171
Query: 327 VSGEAVNSLATTFTGTSYYMAPERI----QGQPYSVTSDVWSLGLTLLEVAQGHSP-FDT 381
++ + A +F GT Y+MAPE I +GQ Y DVWSLG+T +E+A+ P F+
Sbjct: 172 --SASIMAPANSFVGTPYWMAPEVILAMDEGQ-YDGKVDVWSLGITCIELAERKPPLFNM 228
Query: 382 DKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQ 441
+ ++A L + +P L Q WS+ F++F+D L+K +DRP+ +L+
Sbjct: 229 NAMSA------LYHIAQNESPVL-----QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLK 277
Query: 442 HPWMVGQTKKHVNM 455
H +++ + V M
Sbjct: 278 HRFVLRERPPTVIM 291
>Hs14771959 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 719
Score = 119 bits (299), Expect = 7e-27
Identities = 77/264 (29%), Positives = 131/264 (49%), Gaps = 21/264 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+GEG+ G V ++ K A+K + + + +F E+ + D +V Y +
Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKM-DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSY 513
Query: 245 ACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIH 304
+ +++ ME++ G +L + H R+ E+ + + SVLR L YLH + +IH
Sbjct: 514 LVGDE--LWVVMEFLEGGALTDIVTHT-----RMNEEQIATVCLSVLRALSYLHNQGVIH 566
Query: 305 RDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQGQPYSVTSDV 362
RDIK +IL G+IKL DFG + + + GT Y+MAPE I PY D+
Sbjct: 567 RDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDI 626
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLIL-TFTPELKDEPEQGIVWSKSFKSF 421
WSLG+ ++E+ G P+ N PP++ + I + P +KD + S + F
Sbjct: 627 WSLGIMVIEMIDGEPPY------FNEPPLQAMRRIRDSLPPRVKDLHKV----SSVLRGF 676
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWM 445
LD L ++ R + +++L HP++
Sbjct: 677 LDLMLVREPSQRATAQELLGHPFL 700
>7293601 [T] KOG0577 Serine/threonine protein kinase
Length = 1039
Score = 119 bits (298), Expect = 1e-26
Identities = 91/286 (31%), Positives = 141/286 (48%), Gaps = 27/286 (9%)
Query: 167 SDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEK--QIFR 224
+D++ + + + L +G G+ G+V + +I A+K ++ EK I +
Sbjct: 15 ADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILK 74
Query: 225 ELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLG 284
E++F + + Y G + E ST ++ MEY G + D + H + E +
Sbjct: 75 EIRFLRQLNHPNTIEYKGCYLRE--STAWLVMEYCVGSASDIIEVHKKP----LHEDEIA 128
Query: 285 KIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSY 344
I VL GL YLH IHRDIK NIL + G +KL DFG A+ A +F GT Y
Sbjct: 129 AICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFG--SAAIKCPANSFVGTPY 186
Query: 345 YMAPERI----QGQPYSVTSDVWSLGLTLLEVAQGHSP-FDTDKLAANMPPIELLMLILT 399
+MAPE I +GQ Y DVWSLG+T +E+A+ P F+ + ++A L +
Sbjct: 187 WMAPEVILAMDEGQ-YDGKVDVWSLGITCIELAERKPPYFNMNAMSA------LYHIAQN 239
Query: 400 FTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+P L WS +F SF++ LKK +RPS ++L H ++
Sbjct: 240 ESPTLPKND-----WSDAFCSFVELCLKKMPAERPSSAKLLTHAYV 280
>Hs5174547 [T] KOG4279 Serine/threonine protein kinase
Length = 1374
Score = 118 bits (296), Expect = 2e-26
Identities = 88/234 (37%), Positives = 123/234 (51%), Gaps = 17/234 (7%)
Query: 155 EHDRDDSTDELESDIWQ-TYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATI 213
E R + ESD+ + Y+ E D + +LG+GT G V + + A+K I
Sbjct: 656 EKGRSTEEGDCESDLLEYDYEYDENGDRV-VLGKGTYGIVYAGRDLSNQVRIAIKEIP-- 712
Query: 214 ENDGSEKQ-IFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLL 272
E D Q + E+ +K K IV+Y G F+ E I I ME + G SL ++ L
Sbjct: 713 ERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFS--ENGFIKIFMEQVPGGSLSAL---LR 767
Query: 273 SKGGRI--GEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEI-GQIKLCDFGVSG 329
SK G + E+ +G + +L GL YLH+ +I+HRDIK N+L N G +K+ DFG S
Sbjct: 768 SKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSK 827
Query: 330 E--AVNSLATTFTGTSYYMAPERIQGQP--YSVTSDVWSLGLTLLEVAQGHSPF 379
+N TFTGT YMAPE I P Y +D+WSLG T++E+A G PF
Sbjct: 828 RLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPF 881
>7300559 [T] KOG4279 Serine/threonine protein kinase
Length = 1310
Score = 118 bits (296), Expect = 2e-26
Identities = 94/300 (31%), Positives = 148/300 (49%), Gaps = 29/300 (9%)
Query: 159 DDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGS 218
DD+ E E D +++ + +LG+GT G+V + + A+K + +N
Sbjct: 566 DDANIEYEYD-------YDEQNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPE-KNSQD 617
Query: 219 EKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRI 278
+ + E++ + + IVRY G +C E I ME + G SL + L +K G +
Sbjct: 618 VQPLHEEIKLHSQLRHRNIVRYLG--SCSENGFFKIFMEQVPGGSLSDL---LETKWGPL 672
Query: 279 --GEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEI-GQIKLCDFGVSGE--AVN 333
E + ++ +L GL YLHE+ I+HRDIK N+L N G +K+ DFG S +N
Sbjct: 673 KDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARIN 732
Query: 334 SLATTFTGTSYYMAPERI-QG-QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPI 391
+ TFTGT YMAPE I QG + Y +D+WS G T +E+A G PF +
Sbjct: 733 PMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPF------IELGSA 786
Query: 392 ELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKK 451
M + F + + PE+ S + K+F+ DRPS Q+L+ P++ + +K
Sbjct: 787 HAAMFKVGFYKKHPNIPEE---LSANAKNFILRCFAISVMDRPSASQLLEDPFLQDKPRK 843
>CE21025 [D] KOG0580 Serine/threonine protein kinase
Length = 326
Score = 118 bits (295), Expect = 2e-26
Identities = 83/327 (25%), Positives = 154/327 (46%), Gaps = 25/327 (7%)
Query: 141 STSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRN 200
+T+ V +++E+I D ++ ++ + D LG+G G+V + +
Sbjct: 6 NTAPVIDDQKAEVISLTEDSRPQRVDQAREESCWSLDDFDVGRPLGKGKFGNVFISREKK 65
Query: 201 GSKIFALKTIATIE--NDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEY 258
+I ALK + + G Q+ RE++ + I+ YG F + +F+ ++Y
Sbjct: 66 TKRIIALKVLFKTQLLQLGVSHQLKREIEIQYHLRHPNILTLYGYF--HDDKRVFVILDY 123
Query: 259 MGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIG 318
L +V + G ++ E + G+ + L Y H + +IHRDIKP+N+L +
Sbjct: 124 ASRGELFNVLQS--QPGHKVNEVIAGRFVRQLANALHYCHSKGVIHRDIKPENLLLDSKL 181
Query: 319 QIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSP 378
+KL DFG S A +S T GT Y+APE + QP+ D+W++G+ L E+ G++P
Sbjct: 182 NLKLADFGWSVVADHSKRHTLCGTMDYLAPEMVSNQPHDFNVDIWAIGILLFEMLVGYAP 241
Query: 379 FDT---DKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPS 435
F DKL A + ++ + P V + S ++ +KK+ ++R
Sbjct: 242 FANQTGDKLIARIKECKI------YIPS---------VVTDGAASLINAIIKKEPQERLP 286
Query: 436 PRQMLQHPWMVG-QTKKHVNMKKFIQT 461
++ HPW+ + ++ + + FI T
Sbjct: 287 LVDIMAHPWIKEMKQREDIEVPLFIST 313
>At3g07980 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1367
Score = 118 bits (295), Expect = 2e-26
Identities = 89/267 (33%), Positives = 135/267 (50%), Gaps = 24/267 (8%)
Query: 185 LGEGTGGSV-TKCKLRNGSKIFALKTIATIENDGSE--KQIFRELQFNKSCKSDFIVRYY 241
+G+G G V L NG + A+K ++ +EN G E I +E+ K+ IV+Y
Sbjct: 26 IGKGAYGRVYIGLDLENGDFV-AIKQVS-LENIGQEDLNTIMQEIDLLKNLNHKNIVKYL 83
Query: 242 GMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERK 301
G + + + + I +EY+ SL ++ K +K G E ++ VL GL YLHE+
Sbjct: 84 G--SLKTKTHLHIILEYVENGSLANIIKP--NKFGPFPESLVTVYIAQVLEGLVYLHEQG 139
Query: 302 IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFT--GTSYYMAPERIQGQPYSVT 359
+IHRDIK NIL + G +KL DFGV+ + + T + GT Y+MAPE I+
Sbjct: 140 VIHRDIKGANILTTKEGLVKLADFGVATKLNEADFNTHSVVGTPYWMAPEVIELSGVCAA 199
Query: 360 SDVWSLGLTLLEVAQGHSP-FDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSF 418
SD+WS+G T++E+ P +D + A L ++ TP + D S
Sbjct: 200 SDIWSVGCTIIELLTCVPPYYDLQPMPA------LYRIVQDDTPPIPDS------LSPDI 247
Query: 419 KSFLDYSLKKDSKDRPSPRQMLQHPWM 445
FL KKDS+ RP + +L HPW+
Sbjct: 248 TDFLRLCFKKDSRQRPDAKTLLSHPWI 274
>Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 545
Score = 117 bits (294), Expect = 3e-26
Identities = 83/265 (31%), Positives = 134/265 (50%), Gaps = 23/265 (8%)
Query: 185 LGEGTGGSV-TKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
+G+G G+V T + G ++ A+K + ++ ++ I E+ + K+ IV Y
Sbjct: 276 IGQGASGTVYTAMDVATGQEV-AIKQM-NLQQQPKKELIINEILVMRENKNPNIVNYLDS 333
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ + +++ MEY+ G SL V G+I + L+ L +LH ++I
Sbjct: 334 YLVGDE--LWVVMEYLAGGSLTDVVTETCMDEGQIAA-----VCRECLQALEFLHSNQVI 386
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGEAV--NSLATTFTGTSYYMAPERIQGQPYSVTSD 361
HRDIK NIL G +KL DFG + S +T GT Y+MAPE + + Y D
Sbjct: 387 HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVD 446
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT-FTPELKDEPEQGIVWSKSFKS 420
+WSLG+ +E+ +G P+ N P+ L LI T TPEL++ PE+ S F+
Sbjct: 447 IWSLGIMAIEMIEGEPPY------LNENPLRALYLIATNGTPELQN-PEK---LSAIFRD 496
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWM 445
FL+ L D + R S +++LQH ++
Sbjct: 497 FLNRCLDMDVEKRGSAKELLQHQFL 521
>CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 545
Score = 117 bits (294), Expect = 3e-26
Identities = 94/312 (30%), Positives = 150/312 (47%), Gaps = 39/312 (12%)
Query: 167 SDIWQT----YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQI 222
+D W T YK+ E I G G +V ++ A+K I + S ++
Sbjct: 47 ADRWPTEPSAYKLDESI------GVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDEL 100
Query: 223 FRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMG-GRSLDSVYKHLLSKG------ 275
E+Q C +V YY F +E +++ M + G LD + + + + G
Sbjct: 101 SHEIQAMSQCNHPNVVSYYTSFIAQEE--LWVVMRLLNCGSMLDILKRKVKAIGKEQAQF 158
Query: 276 GRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS- 334
G + E + + VL+GL Y H IHRDIK NIL + G I++ DFGVSG +S
Sbjct: 159 GVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSG 218
Query: 335 -------LATTFTGTSYYMAPERI-QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAA 386
+ TF GT +MAPE + Q Q Y +D+WSLG+ +E+A G +P+
Sbjct: 219 GDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYH------ 272
Query: 387 NMPPIELLMLILTFTPEL----KDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQH 442
PP+++LML L P + +Q + KSFK+ + L+KD RP+ ++L++
Sbjct: 273 KYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKY 332
Query: 443 PWM-VGQTKKHV 453
+ G+ KK++
Sbjct: 333 SFFKKGKDKKYL 344
>At3g13530 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1368
Score = 117 bits (294), Expect = 3e-26
Identities = 88/266 (33%), Positives = 134/266 (50%), Gaps = 22/266 (8%)
Query: 185 LGEGTGGSVTK-CKLRNGSKIFALKTIATIENDGSE--KQIFRELQFNKSCKSDFIVRYY 241
+G+G G V K L NG + A+K ++ +EN E I +E+ K+ IV+Y
Sbjct: 26 IGKGAYGRVYKGLDLENGDFV-AIKQVS-LENIVQEDLNTIMQEIDLLKNLNHKNIVKYL 83
Query: 242 GMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERK 301
G + + + + I +EY+ SL ++ K +K G E ++ VL GL YLHE+
Sbjct: 84 G--SSKTKTHLHIILEYVENGSLANIIKP--NKFGPFPESLVAVYIAQVLEGLVYLHEQG 139
Query: 302 IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFT--GTSYYMAPERIQGQPYSVT 359
+IHRDIK NIL + G +KL DFGV+ + + T + GT Y+MAPE I+
Sbjct: 140 VIHRDIKGANILTTKEGLVKLADFGVATKLNEADVNTHSVVGTPYWMAPEVIEMSGVCAA 199
Query: 360 SDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFK 419
SD+WS+G T++E+ P+ ++ P+ L I+ D P S
Sbjct: 200 SDIWSVGCTVIELLTCVPPY------YDLQPMPALFRIVQ-----DDNPPIPDSLSPDIT 248
Query: 420 SFLDYSLKKDSKDRPSPRQMLQHPWM 445
FL KKDS+ RP + +L HPW+
Sbjct: 249 DFLRQCFKKDSRQRPDAKTLLSHPWI 274
>7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 326
Score = 117 bits (294), Expect = 3e-26
Identities = 86/301 (28%), Positives = 148/301 (48%), Gaps = 34/301 (11%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKS- 231
++I+E+I +G V + K + +I ALK I++ E Q+ E ++
Sbjct: 16 FEIYEEI------AQGVNAKVFRAKELDNDRIVALK----IQHYDEEHQVSIEEEYRTLR 65
Query: 232 --CKSDFIVRYYGMFACEETS---TIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGK 285
C + +YG++ + + I+ MEY GG ++D V K LL R+ E+ +
Sbjct: 66 DYCDHPNLPEFYGVYKLSKPNGPDEIWFVMEYCAGGTAVDMVNK-LLKLDRRMREEHIAY 124
Query: 286 IAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLAT--TFTGTS 343
I R L+ ++HRDI+ NIL + G++KLCDFG+S + ++L T G+
Sbjct: 125 IIRETCRAAIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSP 184
Query: 344 YYMAPERIQGQ-----PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLIL 398
+MAPE + +V +DVW+LG+T +E+A G PF A+M P + I+
Sbjct: 185 CWMAPEVVSAMESREPDITVRADVWALGITTIELADGKPPF------ADMHPTRAMFQII 238
Query: 399 TFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKF 458
P P WS+ F+ SL+K++++RP +M++HP++ + M+
Sbjct: 239 RNPPPTLMRPTN---WSQQINDFISESLEKNAENRPMMVEMVEHPFLTELIENEDEMRSD 295
Query: 459 I 459
I
Sbjct: 296 I 296
>At1g09000 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 666
Score = 117 bits (293), Expect = 4e-26
Identities = 87/281 (30%), Positives = 139/281 (48%), Gaps = 30/281 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEK-------QIFRELQFNKSCKSDF 236
++G G G+V + ++ A+K + N S++ ++ E++ K+
Sbjct: 74 LIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPN 133
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IVRY G E T+ I +E++ G S+ S LL K G E V+ +L GL Y
Sbjct: 134 IVRYLG--TVREDDTLNILLEFVPGGSISS----LLEKFGPFPESVVRTYTRQLLLGLEY 187
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGE----AVNSLATTFTGTSYYMAPERIQ 352
LH I+HRDIK NIL + G IKL DFG S + A + A + GT Y+MAPE I
Sbjct: 188 LHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVIL 247
Query: 353 GQPYSVTSDVWSLGLTLLEVAQGHSPFDTD--KLAANMPPIELLMLILTFTPELKDEPEQ 410
+S ++D+WS+G T++E+ G +P+ ++AA + F K P
Sbjct: 248 QTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAA-----------IFFIGTTKSHPPI 296
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKK 451
S K FL L++ RP+ ++L+HP+++G+ K+
Sbjct: 297 PDTLSSDAKDFLLKCLQEVPNLRPTASELLKHPFVMGKHKE 337
>7298926 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 704
Score = 117 bits (293), Expect = 4e-26
Identities = 82/265 (30%), Positives = 132/265 (48%), Gaps = 23/265 (8%)
Query: 185 LGEGTGGSV-TKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
+G+G G+V T + G ++ A+K + + ++ I E+ + K +V Y
Sbjct: 436 IGQGASGTVYTAIESSTGMEV-AIKQM-NLSQQPKKELIINEILVMRENKHPNVVNYLDS 493
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ E +++ MEY+ G SL V G+I + VL+ L +LH ++I
Sbjct: 494 YLVSEE--LWVVMEYLPGGSLTDVVTETCMDEGQIAA-----VCREVLQALEFLHANQVI 546
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGE--AVNSLATTFTGTSYYMAPERIQGQPYSVTSD 361
HRDIK NIL G +KL DFG + S TT GT Y+MAPE + + Y D
Sbjct: 547 HRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVD 606
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT-FTPELKDEPEQGIVWSKSFKS 420
+WSLG+ +E+ +G P+ N P++ L LI T PE+K++ + S +F+
Sbjct: 607 LWSLGIMAIEMVEGEPPY------LNENPLKALYLIATNGKPEIKEKDK----LSSAFQD 656
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWM 445
FLD L+ + R S +L+HP++
Sbjct: 657 FLDQCLEVEVDRRASALDLLKHPFL 681
>Hs4507273 [D] KOG0580 Serine/threonine protein kinase
Length = 275
Score = 116 bits (291), Expect = 6e-26
Identities = 77/269 (28%), Positives = 129/269 (47%), Gaps = 20/269 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYYG 242
LG+G G+V +L+ I ALK + + IE +G E Q+ RE++ + I+R Y
Sbjct: 15 LGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYN 74
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F + +++ +EY L YK L K ++ E+ I E V L Y H++K+
Sbjct: 75 YF--HDARRVYLILEYAPRGEL---YKEL-QKSEKLDEQRTATIIEEVADALTYCHDKKV 128
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDV 362
IHRDIKP+N+L G++K+ DFG S T GT Y+ PE I+G+ Y D+
Sbjct: 129 IHRDIKPENLLLGFRGEVKIADFGWSVHTPLPERKTMCGTLDYLPPEMIEGRTYDEKVDL 188
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFL 422
W +G+ E+ G+ PF++ + T+ LK + + + +
Sbjct: 189 WCIGVLCYELLVGYPPFESASHSE------------TYRRILKVDVRFPLSMPLGARDLI 236
Query: 423 DYSLKKDSKDRPSPRQMLQHPWMVGQTKK 451
L+ +R Q+L+HPW+ +++
Sbjct: 237 SRLLRYQPLERLPLAQILKHPWVQAHSRR 265
>At5g55090 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 448
Score = 116 bits (290), Expect = 8e-26
Identities = 81/266 (30%), Positives = 136/266 (50%), Gaps = 24/266 (9%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
I+G G+ +V+ + N FA+K+ S + RE S +IV+Y G
Sbjct: 11 IIGRGSTATVS-LGITNSGDFFAVKSAEF----SSSAFLQREQSILSKLSSPYIVKYIGS 65
Query: 244 FACEETSTIF--IAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERK 301
+E + + MEY+ G SL + K+ GG++ E ++ +L+GL YLH++
Sbjct: 66 NVTKENDKLMYNLLMEYVSGGSLHDLIKN---SGGKLPEPLIRSYTRQILKGLMYLHDQG 122
Query: 302 IIHRDIKPQNILFNEIGQI-KLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTS 360
I+H D+K QN++ G+I K+ D G + + F+GT +M+PE +G+ S +
Sbjct: 123 IVHCDVKSQNVMIG--GEIAKIVDLGCAKTVEENENLEFSGTPAFMSPEVARGEEQSFPA 180
Query: 361 DVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVW-SKSFK 419
DVW+LG T++E+A G SP+ + + + + FT E P VW S+ +
Sbjct: 181 DVWALGCTVIEMATGSSPW------PELNDVVAAIYKIGFTGESPVIP----VWLSEKGQ 230
Query: 420 SFLDYSLKKDSKDRPSPRQMLQHPWM 445
FL L+KD K R + ++LQHP++
Sbjct: 231 DFLRKCLRKDPKQRWTVEELLQHPFL 256
>7293496 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 805
Score = 116 bits (290), Expect = 8e-26
Identities = 80/272 (29%), Positives = 134/272 (48%), Gaps = 30/272 (11%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSE-KQIFRELQFNKSCKSDFIVRYYG 242
++G+G+ G V K ++ SK+ A+K I+ E K + RE K ++
Sbjct: 9 MVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHVIEMIE 68
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F E + +F+ E+ +L ++++L S G +GE+ ++ ++ L+YLH +I
Sbjct: 69 SF--ESKTDLFVVTEF----ALMDLHRYL-SYNGAMGEEPARRVTGHLVSALYYLHSNRI 121
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAV--NSLATTFTGTSYYMAPERIQGQPYSVTS 360
+HRD+KPQN+L ++ KLCDFG++ + T+ GT YMAPE + QPY +
Sbjct: 122 LHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDHHA 181
Query: 361 DVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSF-- 418
D+WSLG E G PF + + L+ +I + + W +
Sbjct: 182 DMWSLGCIAYESMAGQPPFCASSI------LHLVKMI----------KHEDVKWPSTLTS 225
Query: 419 --KSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
+SFL L+KD R S Q+L HP++ G+
Sbjct: 226 ECRSFLQGLLEKDPGLRISWTQLLCHPFVEGR 257
>ECU07g0360 [D] KOG0580 Serine/threonine protein kinase
Length = 272
Score = 115 bits (287), Expect = 2e-25
Identities = 82/266 (30%), Positives = 123/266 (45%), Gaps = 19/266 (7%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIAT--IENDGSEKQIFRELQFNKSCKSDFIVRYY 241
+LG G G V + R I ALK I I+ + +QI RE++ + + K I+R Y
Sbjct: 15 LLGRGKFGQVWLAREREKGFIVALKIIPIKEIQTVETARQIRREIEIHSNLKHPNILRMY 74
Query: 242 GMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERK 301
G F + I++ +EY G +K L +GG+ GEK V+ L Y+ E
Sbjct: 75 GHF--HDKDNIYLILEYAGKGEF---FKFLSDRGGKFGEKETSLYIRQVMLALTYMKECN 129
Query: 302 IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSD 361
+IHRDIKP+N+L Q+K+ DFG + + TF GT Y+APE + + D
Sbjct: 130 VIHRDIKPENLLLGSDNQLKIADFGWAVYNADKRRMTFCGTMEYLAPEMVNNDIHDSGID 189
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFT-PELKDEPEQGIVWSKSFKS 420
+W LG+ E G +PF++ NM + L +T PE S +
Sbjct: 190 LWCLGILTYEFLMGKTPFESKN--RNMREAYKKINSLKYTIPE---------TISSNASD 238
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWMV 446
F+ L DR + L HP++V
Sbjct: 239 FISRLLVLSPGDRMELTEALNHPFIV 264
>CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 572
Score = 115 bits (287), Expect = 2e-25
Identities = 81/266 (30%), Positives = 132/266 (49%), Gaps = 25/266 (9%)
Query: 185 LGEGTGGSV-TKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
+G G GSV T ++ +++ A+K + +++ ++ I E+ + K IV Y
Sbjct: 301 IGSGASGSVYTAIEISTEAEV-AIKQM-NLKDQPKKELIINEILVMRENKHANIVNYLDS 358
Query: 244 F-ACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
+ C+E +++ MEY+ G SL V + G ++ + VL+ L +LH R +
Sbjct: 359 YLVCDE---LWVVMEYLAGGSLTDVVTECQMEDG-----IIAAVCREVLQALEFLHSRHV 410
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGE--AVNSLATTFTGTSYYMAPERIQGQPYSVTS 360
IHRDIK NIL G +KL DFG + TT GT Y+MAPE + + Y
Sbjct: 411 IHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKV 470
Query: 361 DVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT-FTPELKDEPEQGIVWSKSFK 419
DVWSLG+ +E+ +G P+ N P+ + LI T P+ ++ FK
Sbjct: 471 DVWSLGIMAIEMVEGEPPY------LNENPLRAIYLIATNGKPDFPGRDSMTLL----FK 520
Query: 420 SFLDYSLKKDSKDRPSPRQMLQHPWM 445
F+D +L+ ++R S Q+L HP++
Sbjct: 521 DFVDSALEVQVENRWSASQLLTHPFL 546
>SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 589
Score = 114 bits (285), Expect = 3e-25
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 26/280 (9%)
Query: 176 HEQIDTLGI---LGEGTGGSVTKCKLRNGSKIFALKTIAT----IENDGSEKQIFRELQF 228
H+ ++ + LG+G GSV K+ G ++ ++A ++ ++ I E+
Sbjct: 303 HDPVEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKELILNEITV 362
Query: 229 NKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAE 288
+ IV Y F E +++ MEYM SL + + ++ E + +I
Sbjct: 363 MRESIHPNIVTYLDSFLVRERH-LWVVMEYMNAGSLTDIIEK-----SKLTEAQIARICL 416
Query: 289 SVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN--SLATTFTGTSYYM 346
+G+ +LH R IIHRDIK N+L + G IK+ DFG N + T GT Y+M
Sbjct: 417 ETCKGIQHLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPYWM 476
Query: 347 APERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLIL-TFTPELK 405
APE ++ Y D+WSLG+ ++E+ + P+ PI L LI TP LK
Sbjct: 477 APEVVKQNEYGTKVDIWSLGIMIIEMIENEPPY------LREDPIRALYLIAKNGTPTLK 530
Query: 406 DEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+P + SK+ KSFL+ L D+ R + ++L H ++
Sbjct: 531 -KPN---LVSKNLKSFLNSCLTIDTIFRATAAELLTHSFL 566
>Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 681
Score = 114 bits (284), Expect = 4e-25
Identities = 84/331 (25%), Positives = 161/331 (48%), Gaps = 27/331 (8%)
Query: 118 TQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHE 177
T A TSNL D PT + G+++ ++ H++ + + D +
Sbjct: 354 TWHAQISTSNLYLPQD--PTVAKGALA---GEDTGVVTHEQFKAALRMVVDQGDPRLL-- 406
Query: 178 QIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFI 237
+D+ +GEG+ G V + ++ + A+K + + + +F E+ + + +
Sbjct: 407 -LDSYVKIGEGSTGIVCLAREKHSGRQVAVKMM-DLRKQQRRELLFNEVVIMRDYQHFNV 464
Query: 238 VRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYL 297
V Y + E +++ ME++ G +L + + R+ E+ + + E+VL+ L YL
Sbjct: 465 VEMYKSYLVGEE--LWVLMEFLQGGALTDIVSQV-----RLNEEQIATVCEAVLQALAYL 517
Query: 298 HERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQGQP 355
H + +IHRDIK +IL G++KL DFG + + + GT Y+MAPE I
Sbjct: 518 HAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSL 577
Query: 356 YSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWS 415
Y+ D+WSLG+ ++E+ G P+ +D P + L + P+LK+ + S
Sbjct: 578 YATEVDIWSLGIMVIEMVDGEPPYFSDS-----PVQAMKRLRDSPPPKLKNSHKV----S 628
Query: 416 KSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
+ FL+ L +D ++R + +++L HP+++
Sbjct: 629 PVLRDFLERMLVRDPQERATAQELLDHPFLL 659
>At4g26890 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 444
Score = 114 bits (284), Expect = 4e-25
Identities = 79/265 (29%), Positives = 132/265 (49%), Gaps = 24/265 (9%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
I+G G+ +V+ + + ++FA+K+ S + +E + S +V+Y G
Sbjct: 10 IIGRGSTATVS-IAISSSGELFAVKSADL----SSSSLLQKEQSILSTLSSPHMVKYIGT 64
Query: 244 FACEETSTIF--IAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERK 301
E++ + I MEY+ G +L + K+ GG++ E + +L GL YLHER
Sbjct: 65 GLTRESNGLVYNILMEYVSGGNLHDLIKN---SGGKLPEPEIRSYTRQILNGLVYLHERG 121
Query: 302 IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSD 361
I+H D+K N+L E G +K+ D G + S F+GT +MAPE +G+ +D
Sbjct: 122 IVHCDLKSHNVLVEENGVLKIADMGCAKSVDKS---EFSGTPAFMAPEVARGEEQRFPAD 178
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVW-SKSFKS 420
VW+LG T++E+ G SP+ + + M + F+ E P W S K
Sbjct: 179 VWALGCTMIEMMTGSSPW------PELNDVVAAMYKIGFSGESPAIP----AWISDKAKD 228
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWM 445
FL LK+D K R + ++L+HP++
Sbjct: 229 FLKNCLKEDQKQRWTVEELLKHPFL 253
>7302861 [T] KOG0696 Serine/threonine protein kinase
Length = 700
Score = 114 bits (284), Expect = 4e-25
Identities = 72/204 (35%), Positives = 105/204 (51%), Gaps = 11/204 (5%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTI---ATIENDGSEKQIFRELQFNKSCKSDFIVRY 240
++G+G+ G V + R +++A+K + I+ D E + + S + F+V
Sbjct: 376 VIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSM 435
Query: 241 YGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
+ F + +F MEY G L + + + GR E V A V LF+LHER
Sbjct: 436 HSCF--QTMDRLFFVMEYCKGGDL----MYHMQQYGRFKESVAIFYAVEVAIALFFLHER 489
Query: 301 KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLAT--TFTGTSYYMAPERIQGQPYSV 358
II+RD+K NIL + G +KL DFG+S E V T TF GT YMAPE + PYS+
Sbjct: 490 DIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSI 549
Query: 359 TSDVWSLGLTLLEVAQGHSPFDTD 382
+D WS G+ L E G +PF+ D
Sbjct: 550 AADWWSFGVLLFEFMAGQAPFEGD 573
>Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 291
Score = 114 bits (284), Expect = 4e-25
Identities = 79/272 (29%), Positives = 132/272 (48%), Gaps = 25/272 (9%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQ-----IFRELQFNKSCKSDFIVR 239
+G G S + + + A+K + + N SE++ + E++ I+R
Sbjct: 26 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 85
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
G + +FI E+M G S+ HLLSK G E V+ E +LRGL YLHE
Sbjct: 86 MLGATCEKSNYNLFI--EWMAGGSV----AHLLSKYGAFKESVVINYTEQLLRGLSYLHE 139
Query: 300 RKIIHRDIKPQNILFNEIGQ-IKLCDFGVS------GEAVNSLATTFTGTSYYMAPERIQ 352
+IIHRD+K N+L + GQ +++ DFG + G GT +MAPE ++
Sbjct: 140 NQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLR 199
Query: 353 GQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPI-ELLMLILTFTPELKDEPEQG 411
GQ Y + DVWS+G ++E+A P++ +K + ++ I ++++ T P + G
Sbjct: 200 GQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKVIIASATTAPSIPSHLSPG 259
Query: 412 IVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHP 443
+ + L+ +DRP R++L+HP
Sbjct: 260 L------RDVALRCLELQPQDRPPSRELLKHP 285
>CE04493 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 449
Score = 113 bits (283), Expect = 5e-25
Identities = 76/212 (35%), Positives = 116/212 (53%), Gaps = 19/212 (8%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIAT-----IENDGSEKQIFRELQ----FNKSCKSD 235
+G G G S + NG K+ A K +A ++ D + K + ++L+ N
Sbjct: 210 IGNGEGQSAVYRLIYNG-KLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVINGCAPCP 268
Query: 236 FIVRYYGMFACE--ETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRG 293
FIV ++G + + + I I ME M S + L +GG I E V+G+I SV+
Sbjct: 269 FIVHFFGYYVHKYRDCVKIHIFMEEMA-LSASVLKTEALKQGGAIPEFVIGRIVCSVIHA 327
Query: 294 LFYLHER-KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPE--- 349
+++L +R +IIHRDIKP NIL + G++K+CDFG+ G NS+A + TG Y APE
Sbjct: 328 MWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENSIAVSDTGCQQYTAPEILV 387
Query: 350 -RIQGQP-YSVTSDVWSLGLTLLEVAQGHSPF 379
+ P YS+ SD+WSLG+T+ E+A P+
Sbjct: 388 KGVSNSPGYSIKSDIWSLGITIFELATLRYPY 419
>YAR019c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 974
Score = 113 bits (282), Expect = 7e-25
Identities = 82/265 (30%), Positives = 128/265 (47%), Gaps = 25/265 (9%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
++G G+ G V K ++ ++ A+K + END I E+ K+ + IV+Y+G
Sbjct: 30 VIGRGSYGVVYKAINKHTDQVVAIKEVV-YENDEELNDIMAEISLLKNLNHNNIVKYHGF 88
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGR-IGEKVLGKIAESVLRGLFYLHERKI 302
++ ++I +EY SL + L+S+ + E L GL YLH +
Sbjct: 89 I--RKSYELYILLEYCANGSL----RRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGV 142
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDV 362
IHRDIK NIL + +KL DFGVS VNS A T GT +MAPE + + S SD+
Sbjct: 143 IHRDIKAANILLSADNTVKLADFGVS-TIVNSSALTLAGTLNWMAPEILGNRGASTLSDI 201
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLIL--TFTPELKDEPEQGIVWSKSFKS 420
WSLG T++E+ + P+ N+ + + T+ P +S+ K
Sbjct: 202 WSLGATVVEMLTKNPPYH------NLTDANIYYAVENDTYYPPSS--------FSEPLKD 247
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWM 445
FL K+ RP+ Q+L+H W+
Sbjct: 248 FLSKCFVKNMYKRPTADQLLKHVWI 272
>At2g25880 [D] KOG0580 Serine/threonine protein kinase
Length = 282
Score = 113 bits (282), Expect = 7e-25
Identities = 78/264 (29%), Positives = 124/264 (46%), Gaps = 19/264 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYYG 242
LG G G V + + I ALK + A ++ E Q+ RE++ + I+R YG
Sbjct: 25 LGRGKFGHVYLAREKRSDHIVALKVLFKAQLQQSQVEHQLRREVEIQSHLRHPNILRLYG 84
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F + +++ +EY L YK L K E+ S+ R L Y H + +
Sbjct: 85 YFY--DQKRVYLILEYAVRGEL---YKEL-QKCKYFSERRAATYVASLARALIYCHGKHV 138
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDV 362
IHRDIKP+N+L G++K+ DFG S N T GT Y+ PE ++ + + D+
Sbjct: 139 IHRDIKPENLLIGAQGELKIADFGWSVHTFNR-RRTMCGTLDYLPPEMVESVEHDASVDI 197
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFL 422
WSLG+ E G PF+ + + ++ + L F P+ + S S K +
Sbjct: 198 WSLGILCYEFLYGVPPFEAREHSETYK--RIVQVDLKFPPK--------PIVSSSAKDLI 247
Query: 423 DYSLKKDSKDRPSPRQMLQHPWMV 446
L K+S R + ++L+HPW+V
Sbjct: 248 SQMLVKESTQRLALHKLLEHPWIV 271
>At3g06030 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 651
Score = 112 bits (281), Expect = 9e-25
Identities = 89/281 (31%), Positives = 139/281 (48%), Gaps = 30/281 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSE-------KQIFRELQFNKSCKSDF 236
++G G G V + ++ A+K + + S+ +++ E+Q K+
Sbjct: 73 LIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPN 132
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IVRY G E+ ++ I ME++ G S+ S LL K G E V+ + +L GL Y
Sbjct: 133 IVRYLG--TVRESDSLNILMEFVPGGSISS----LLEKFGSFPEPVIIMYTKQLLLGLEY 186
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN----SLATTFTGTSYYMAPERIQ 352
LH I+HRDIK NIL + G I+L DFG S + V + A + GT Y+MAPE I
Sbjct: 187 LHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVIL 246
Query: 353 GQPYSVTSDVWSLGLTLLEVAQGHSPFDT--DKLAANMPPIELLMLILTFTPELKDEPEQ 410
+S ++D+WS+G T++E+A G P+ + AA +L + T PE
Sbjct: 247 QTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAA--------VLHIGRTKAHPPIPED 298
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKK 451
S K FL L K+ R S ++LQHP++ G+ ++
Sbjct: 299 ---LSPEAKDFLMKCLHKEPSLRLSATELLQHPFVTGKRQE 336
>Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 476
Score = 112 bits (280), Expect = 1e-24
Identities = 87/293 (29%), Positives = 138/293 (46%), Gaps = 18/293 (6%)
Query: 163 DELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQI 222
D+ S QT I + + +LG G V K R K+FALK I + +
Sbjct: 7 DDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK-SPAFRDSSL 65
Query: 223 FRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKV 282
E+ K K + IV ++ E T+ ++ M+ + G L + +L +G EK
Sbjct: 66 ENEIAVLKKIKHENIVTLEDIY--ESTTHYYLVMQLVSGGEL---FDRILERGVYT-EKD 119
Query: 283 LGKIAESVLRGLFYLHERKIIHRDIKPQNILF---NEIGQIKLCDFGVSGEAVNSLATTF 339
+ + VL + YLHE I+HRD+KP+N+L+ E +I + DFG+S N + +T
Sbjct: 120 ASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTA 179
Query: 340 TGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT 399
GT Y+APE + +PYS D WS+G+ + G+ PF + + I+
Sbjct: 180 CGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIK--EGYYE 237
Query: 400 FTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKH 452
F D+ S+S K F+ + L+KD +R + + L HPW+ G T H
Sbjct: 238 FESPFWDD------ISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALH 284
>CE27177 [T] KOG4279 Serine/threonine protein kinase
Length = 1378
Score = 112 bits (280), Expect = 1e-24
Identities = 84/270 (31%), Positives = 133/270 (49%), Gaps = 21/270 (7%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
+LG+GT G+V + + + +K I ++ D + + E+ + + IV+Y G
Sbjct: 669 VLGKGTYGTVYAARDMDTQRQIVVKEIE-VKYDEEVQPLMEEISLHSTLCHANIVQYLGC 727
Query: 244 FACEETST---IFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
+ + I ME++ G SL S+ L SK G + E + + +L GL YLHE
Sbjct: 728 DLVGKDGSNDHFLIFMEHVPGGSLSSL---LRSKWGPMNENAMNYYGKQILEGLKYLHEL 784
Query: 301 KIIHRDIKPQNILFNEI-GQIKLCDFGVSGE--AVNSLATTFTGTSYYMAPERI-QGQ-P 355
KI+HRDIK N+L N G K+ DFG +N + TFTGT YMAPE I GQ
Sbjct: 785 KIVHRDIKGDNVLVNTYSGVCKISDFGTCKRLAGLNPVTETFTGTLQYMAPEVIDHGQRG 844
Query: 356 YSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWS 415
Y +D+WS G T++E+A G PF + P + + + K P +
Sbjct: 845 YGAPADIWSFGCTMVEMATGRPPF----VEMQNPQAAMFRVGM-----FKTHPPIPTEIT 895
Query: 416 KSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ ++F+ ++ DRPS + +LQ P++
Sbjct: 896 EKCRNFIKSCFLPEACDRPSAKDLLQDPFI 925
>At2g32510 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 372
Score = 112 bits (280), Expect = 1e-24
Identities = 73/266 (27%), Positives = 132/266 (49%), Gaps = 18/266 (6%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
ILG G+ +V N +I A+K+ ++ + RE + S S +++ Y G
Sbjct: 8 ILGRGSTATVYAAAGHNSDEILAVKSSEVHRSEFLQ----REAKILSSLSSPYVIGYRGS 63
Query: 244 FACEETSTIF---IAMEYMG-GRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
E++ + + MEY G D+ K GGR+ E + K +L+GL Y+H
Sbjct: 64 ETKRESNGVVMYNLLMEYAPYGTLTDAAAKD----GGRVDETRVVKYTRDILKGLEYIHS 119
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVT 359
+ I+H D+K N++ +E G+ K+ DFG + + GT +MAPE +G+
Sbjct: 120 KGIVHCDVKGSNVVISEKGEAKIADFGCAKRVDPVFESPVMGTPAFMAPEVARGEKQGKE 179
Query: 360 SDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFK 419
SD+W++G T++E+ G P+ K + P+ +L + + PE + ++ K
Sbjct: 180 SDIWAVGCTMIEMVTGSPPW--TKADSREDPVSVLYRV----GYSSETPELPCLLAEEAK 233
Query: 420 SFLDYSLKKDSKDRPSPRQMLQHPWM 445
FL+ LK+++ +R + Q+L HP++
Sbjct: 234 DFLEKCLKREANERWTATQLLNHPFL 259
>At1g63700 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 883
Score = 112 bits (279), Expect = 2e-24
Identities = 82/268 (30%), Positives = 139/268 (51%), Gaps = 22/268 (8%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDG----SEKQIFRELQFNKSCKSDFIVR 239
+LG G+ G V ++ A+K + +D S +Q+ +E+ + IV+
Sbjct: 405 LLGMGSFGHVYLGFNSESGEMCAMKEVTLCSDDPKSRESAQQLGQEISVLSRLRHQNIVQ 464
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
YYG ++ ++I +EY+ G S+YK LL + G+ GE + + +L GL YLH
Sbjct: 465 YYGSETVDDK--LYIYLEYVSG---GSIYK-LLQEYGQFGENAIRNYTQQILSGLAYLHA 518
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGE-AVNSLATTFTGTSYYMAPERIQGQPYS- 357
+ +HRDIK NIL + G++K+ DFG++ S +F G+ Y+MAPE I+ S
Sbjct: 519 KNTVHRDIKGANILVDPHGRVKVADFGMAKHITAQSGPLSFKGSPYWMAPEVIKNSNGSN 578
Query: 358 VTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKS 417
+ D+WSLG T+LE+A P+ + +P M + + EL D P+ S+
Sbjct: 579 LAVDIWSLGCTVLEMATTKPPWSQYE---GVP----AMFKIGNSKELPDIPDH---LSEE 628
Query: 418 FKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
K F+ L+++ +RP+ Q+L H ++
Sbjct: 629 GKDFVRKCLQRNPANRPTAAQLLDHAFV 656
>YPL150w [T] KOG0583 Serine/threonine protein kinase
Length = 901
Score = 110 bits (276), Expect = 3e-24
Identities = 86/276 (31%), Positives = 135/276 (48%), Gaps = 32/276 (11%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSC 232
YKI +QI GEG+ G V R + LKT +D ++ I RE+ +++
Sbjct: 41 YKILKQI------GEGSFGKVYLALHRPTHRKVCLKT-----SDKNDPNIVREVFYHRQF 89
Query: 233 KSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
+I + Y + E S +++A+EY G+ L Y HLLS RI G++ +
Sbjct: 90 DFPYITKLYEVIVTE--SKVWMALEYCPGKEL---YDHLLSLR-RISLLECGELFAQISG 143
Query: 293 GLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAV-NSLATTFTGTSYYMAPERI 351
++Y H +HRD+K +NIL ++ G KL DFG + E + + T GT+ YMAPE I
Sbjct: 144 AVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTRECMTKTTLETVCGTTVYMAPELI 203
Query: 352 QGQPY-SVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE- 409
+ + Y D+WSLG+ L + G+ PFD D A I + +EP+
Sbjct: 204 ERRTYDGFKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKI------------VNEEPKY 251
Query: 410 QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
V + + L K+ +RPS Q+L+HP++
Sbjct: 252 DAKVIPDDARDLISRLLAKNPGERPSLSQVLRHPFL 287
>At4g32830 [D] KOG0580 Serine/threonine protein kinase
Length = 294
Score = 110 bits (276), Expect = 3e-24
Identities = 76/264 (28%), Positives = 124/264 (46%), Gaps = 19/264 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYYG 242
LG G G V + + + + ALK + + ++ E Q+ RE++ + I+R YG
Sbjct: 37 LGRGKFGHVYLAREKRSNHVVALKVLFKSQLQQSQVEHQLRREVEIQSHLRHPNILRLYG 96
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F + +++ +EY L YK L K E+ S+ R L Y H + +
Sbjct: 97 YFY--DQKRVYLILEYAARGEL---YKDL-QKCKYFSERRAATYVASLARALIYCHGKHV 150
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDV 362
IHRDIKP+N+L G++K+ DFG S N T GT Y+ PE ++ + + D+
Sbjct: 151 IHRDIKPENLLIGAQGELKIADFGWSVHTFNR-RRTMCGTLDYLPPEMVESVEHDASVDI 209
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFL 422
WSLG+ E G PF+ + + ++ + L F P+ + S S K +
Sbjct: 210 WSLGILCYEFLYGVPPFEAMEHSDTYR--RIVQVDLKFPPK--------PIISASAKDLI 259
Query: 423 DYSLKKDSKDRPSPRQMLQHPWMV 446
L K+S R ++L+HPW+V
Sbjct: 260 SQMLVKESSQRLPLHKLLEHPWIV 283
>At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 710
Score = 110 bits (276), Expect = 3e-24
Identities = 81/282 (28%), Positives = 138/282 (48%), Gaps = 28/282 (9%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSC 232
YK+ E+I G G V + +++ A+K + + + I RE Q
Sbjct: 33 YKLMEEI------GHGASAVVYRAIYLPTNEVVAIKCLDLDRCNSNLDDIRRESQTMSLI 86
Query: 233 KSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
+++ + F+ + + +++ M +M S + K S G E + + + L+
Sbjct: 87 DHPNVIKSFCSFSVDHS--LWVVMPFMAQGSCLHLMKTAYSDG--FEESAICCVLKETLK 142
Query: 293 GLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS-----LATTFTGTSYYMA 347
L YLH + IHRD+K NIL ++ G+IKL DFGVS ++ TF GT +MA
Sbjct: 143 ALDYLHRQGHIHRDVKAGNILLDDNGEIKLGDFGVSACLFDNGDRQRARNTFVGTPCWMA 202
Query: 348 PERIQ-GQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTP---- 402
PE +Q G Y+ +D+WS G+T LE+A GH+PF + PP+++L++ + P
Sbjct: 203 PEVLQPGNGYNSKADIWSFGITALELAHGHAPF------SKYPPMKVLLMTIQNAPPGLD 256
Query: 403 --ELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQH 442
K ++ ++SFK + L KD RP+ ++L+H
Sbjct: 257 YDRDKKFSKRTFSCAQSFKEMVAMCLVKDQTKRPTAEKLLKH 298
>Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 455
Score = 110 bits (275), Expect = 4e-24
Identities = 71/205 (34%), Positives = 105/205 (50%), Gaps = 13/205 (6%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
E +TLG +GEG+ G+V KCK +N +I A+K K RE++F K +
Sbjct: 2 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHEN 61
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSV--YKHLLSKGGRIGEKVLGKIAESVLRGL 294
+V +F + I + E++ LD + Y H L K L K +LR +
Sbjct: 62 LVNLIEVF--RQKKKIHLVFEFIDHTVLDELQHYCHGLES------KRLRKYLFQILRAI 113
Query: 295 FYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFTGTSYYMAPERI- 351
YLH IIHRDIKP+NIL ++ G KLCDFG + A + T + T +Y APE +
Sbjct: 114 DYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVL 173
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGH 376
+ Y D+W+LG ++E+A G+
Sbjct: 174 KDTSYGKPVDIWALGCMIIEMATGN 198
>CE01405 [T] KOG0577 Serine/threonine protein kinase
Length = 982
Score = 110 bits (275), Expect = 4e-24
Identities = 90/274 (32%), Positives = 136/274 (48%), Gaps = 33/274 (12%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEK--QIFRELQFNKSCKSDFIVRYYG 242
+G G+ G+V + + A+K + EK I +E+ F + IV Y
Sbjct: 36 IGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVVHPHIVDYKA 95
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F + +T ++ MEY G + D V +L KG R E + I L L YLH K
Sbjct: 96 CFL--KDTTCWLVMEYCIGSAADIV--DVLRKGMR--EVEIAAICSQTLDALRYLHSLKR 149
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQP---YSVT 359
IHRDIK NIL ++ +KL DFG S V+ A TF GT ++MAPE I Y+
Sbjct: 150 IHRDIKAGNILLSDHAIVKLADFG-SASLVDP-AQTFIGTPFFMAPEVILAMDEGHYTDR 207
Query: 360 SDVWSLGLTLLEVAQGHSP-FDTDKLAA------NMPPIELLMLILTFTP-ELKDEPEQG 411
+D+WSLG+T +E+A+ P F + ++A N PP T +P + ++PE
Sbjct: 208 ADIWSLGITCIELAERRPPLFSMNAMSALYHIAQNDPP--------TLSPIDTSEQPE-- 257
Query: 412 IVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
WS F F+D L+K +++R S + +HP++
Sbjct: 258 --WSLEFVQFIDKCLRKPAEERMSAEECFRHPFI 289
>At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 693
Score = 110 bits (274), Expect = 6e-24
Identities = 83/297 (27%), Positives = 139/297 (45%), Gaps = 28/297 (9%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSC 232
YK+ E++ G G V + +++ A+K++ + + I RE Q
Sbjct: 27 YKLMEEV------GYGASAVVHRAIYLPTNEVVAIKSLDLDRCNSNLDDIRREAQTMTLI 80
Query: 233 KSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
+++ + FA + +++ M +M S + K G E + + + L+
Sbjct: 81 DHPNVIKSFCSFAVDHH--LWVVMPFMAQGSCLHLMKAAYPDG--FEEAAICSMLKETLK 136
Query: 293 GLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS-----LATTFTGTSYYMA 347
L YLH + IHRD+K NIL ++ G+IKL DFGVS ++ TF GT +MA
Sbjct: 137 ALDYLHRQGHIHRDVKAGNILLDDTGEIKLGDFGVSACLFDNGDRQRARNTFVGTPCWMA 196
Query: 348 PERIQ-GQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKD 406
PE +Q G Y+ +D+WS G+T LE+A GH+PF + PP+++L++ + P D
Sbjct: 197 PEVLQPGSGYNSKADIWSFGITALELAHGHAPF------SKYPPMKVLLMTIQNAPPGLD 250
Query: 407 EPEQGIVWSK------SFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKK 457
K SFK + L KD RP+ ++L+H + + +KK
Sbjct: 251 YDRDKKFSKKMSSCAQSFKELVALCLVKDQTKRPTAEKLLKHSFFKNVKPPEICVKK 307
>At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 269
Score = 110 bits (274), Expect = 6e-24
Identities = 83/286 (29%), Positives = 139/286 (48%), Gaps = 23/286 (8%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATI-ENDGSEKQIFRELQFNKSCKSD 235
E + ++GEG+ G V K + + + A+K I + D + +E++ + K +
Sbjct: 4 EDYHVIELVGEGSFGRVYKGRRKYTGQTVAMKFIMKQGKTDKDIHSLRQEIEILRKLKHE 63
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
I+ F E + E+ G + +L + E+ + IA+ +++ L
Sbjct: 64 NIIEMLDSF--ENAREFCVVTEFAQGELFE-----ILEDDKCLPEEQVQAIAKQLVKALD 116
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVS-GEAVNSLA-TTFTGTSYYMAPERIQG 353
YLH +IIHRD+KPQNIL +KLCDFG + + N++ + GT YMAPE ++
Sbjct: 117 YLHSNRIIHRDMKPQNILIGAGSVVKLCDFGFARAMSTNTVVLRSIKGTPLYMAPELVKE 176
Query: 354 QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
QPY T D+WSLG+ L E+ G PF T+ + A + I +KD +
Sbjct: 177 QPYDRTVDLWSLGVILYELYVGQPPFYTNSVYALIRHI------------VKDPVKYPDE 224
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFI 459
S F+SFL L K+ R + + +HP+ V +T++ V + +
Sbjct: 225 MSTYFESFLKGLLNKEPHSRLTWPALREHPF-VKETQEEVEARVMV 269
>7300149 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 569
Score = 109 bits (273), Expect = 8e-24
Identities = 79/323 (24%), Positives = 145/323 (44%), Gaps = 31/323 (9%)
Query: 135 EPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKI-------HEQIDTLGILGE 187
+P + + + + I+ ++ + +++I+ + E+ T +G+
Sbjct: 242 KPAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGK 301
Query: 188 GTGGSV-TKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFAC 246
G G V L+N S++ A+KTI ++N S+ I E++ K +V + +
Sbjct: 302 GASGIVFIAADLQNESQV-AVKTI-DMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLL 359
Query: 247 EETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRD 306
E +++ MEYM G L V + K E+ + + L + +LH + IIHRD
Sbjct: 360 EPEDQLWVVMEYMDGGPLTDVVTETVMK-----ERQIACVCRETLYAISFLHAKGIIHRD 414
Query: 307 IKPQNILFNEIGQIKLCDFGVSGEAV-NSLATTFTGTSYYMAPERIQGQPYSVTSDVWSL 365
IK N+L G +K+ DFG + T GT Y+MAPE + + Y D+WS+
Sbjct: 415 IKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSI 474
Query: 366 GLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSK---SFKSFL 422
G+ +E+ +G P+ P L ++ P++K W K + + FL
Sbjct: 475 GIMAIEMIEGQPPY-----LYETPLRALYLIAANGRPDIKS-------WDKLSPNLQDFL 522
Query: 423 DYSLKKDSKDRPSPRQMLQHPWM 445
D L+ + R + ++L HP++
Sbjct: 523 DRCLQVEVDRRATADELLSHPFL 545
>SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase
Length = 652
Score = 108 bits (271), Expect = 1e-23
Identities = 74/206 (35%), Positives = 113/206 (53%), Gaps = 19/206 (9%)
Query: 182 LGILGEGTGGSVTK--CKLRNGSKIFALKTIATIENDGSEKQ----IFRELQFNKSCKSD 235
L ++G G+ G+V + C L + + + T E++ S+ Q + EL K +
Sbjct: 13 LELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSEL---KQSDVE 69
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
I++Y+G + + ++I M+Y G S+ + L + G I E + I L+ L
Sbjct: 70 NIIKYHGSYLVG--TNLWIIMDYCHGGSVRT-----LMEAGPISEPCISLILRETLQALK 122
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEA-VN-SLATTFTGTSYYMAPERIQ- 352
++H IIHRDIK NIL + G +KLCDFGV+ E +N TF GT Y+MAPE I+
Sbjct: 123 FIHHAGIIHRDIKAANILVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRD 182
Query: 353 GQPYSVTSDVWSLGLTLLEVAQGHSP 378
GQ Y+V +D+WSLG+T E+A G P
Sbjct: 183 GQEYNVMADIWSLGITAYEIATGSPP 208
>Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 626
Score = 108 bits (271), Expect = 1e-23
Identities = 72/209 (34%), Positives = 108/209 (51%), Gaps = 21/209 (10%)
Query: 184 ILGEGTGGSVTKC-KLRNGSKIFALKTIATIENDGSEKQIFR---ELQFNKSCKSDFIVR 239
+LG+G G V C + G ++ + + ++ + K++ E+Q K+ + + IV+
Sbjct: 367 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQ 426
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
YYG T+ I MEYM G S+ K L G + E V K +L G+ YLH
Sbjct: 427 YYGCLRDRAEKTLTIFMEYMPGGSV----KDQLKAYGALTESVTRKYTRQILEGMSYLHS 482
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFG---------VSGEAVNSLATTFTGTSYYMAPER 350
I+HRDIK NIL + G +KL DFG +SG + S+ TGT Y+M+PE
Sbjct: 483 NMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSV----TGTPYWMSPEV 538
Query: 351 IQGQPYSVTSDVWSLGLTLLEVAQGHSPF 379
I G+ Y +DVWSLG T++E+ P+
Sbjct: 539 ISGEGYGRKADVWSLGCTVVEMLTEKPPW 567
>CE21239 [T] KOG0583 Serine/threonine protein kinase
Length = 367
Score = 108 bits (271), Expect = 1e-23
Identities = 107/364 (29%), Positives = 158/364 (43%), Gaps = 41/364 (11%)
Query: 106 TDHLPTSGSQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEI----IEHDRDDS 161
T PT S + ++ SMY T S+S H + S + +H S
Sbjct: 2 TSEEPTRAQWSSREDRENQPPMPGSMYTKHSTYSTSKHPTTHTRTSYMPSKSSQHHHPAS 61
Query: 162 TDE-----LESDIWQTYKIHE----------QIDTLGILGEGTGGSVTKCKLRNGSKIFA 206
+ SD + Y I + +DT LG G V K RN +++ A
Sbjct: 62 SSHHNHHRKRSDATKRYAIEDFRQAFARKGMDLDTSNKLGRGKYSKVYKAFDRNNNRVVA 121
Query: 207 LKTIATIE--NDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMG-GRS 263
+K I T E D K + REL + K+ F+V + + E S IF+ MEY G
Sbjct: 122 VKAIDTQELTTDVKMKFLPRELSCWRKLKNPFVVGLHAQY--EAQSMIFLTMEYGSQGDL 179
Query: 264 LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLC 323
L V +H G I E+ G ++RGL ++H I HRDIK +NI+ + +KL
Sbjct: 180 LRYVQEH-----GGIHEQKAGLFMSQLIRGLQFMHSINIAHRDIKLENIILFD-NCVKLS 233
Query: 324 DFG-VSGEAVNSLATTFTGTSYYMAPERIQGQPYS-VTSDVWSLGLTLLEVAQGHSPFDT 381
DFG V ++L++TF G+ Y APE ++G Y+ SDVWSLG+ + PFD
Sbjct: 234 DFGFVRKMDESALSSTFCGSKSYSAPELLRGIVYNPFLSDVWSLGVVGFVMVTNRMPFDE 293
Query: 382 DKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQ 441
K N +EL P + S S S + + D+++RP+ L
Sbjct: 294 KK--PNNVIVELQRNRQYVIP-------HSVFLSTSCISSFESMMAFDTRNRPTSTDCLA 344
Query: 442 HPWM 445
PW+
Sbjct: 345 LPWI 348
>At1g54960 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 585
Score = 108 bits (271), Expect = 1e-23
Identities = 86/295 (29%), Positives = 140/295 (47%), Gaps = 31/295 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEK-------QIFRELQFNKSCKSDF 236
++G G G+V + ++ A+K + N S++ ++ E++ K+
Sbjct: 73 LIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPN 132
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
IVRY G E T+ I +E++ G S+ S LL K G E V+ +L GL Y
Sbjct: 133 IVRYLG--TVREDETLNILLEFVPGGSISS----LLEKFGAFPESVVRTYTNQLLLGLEY 186
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGE----AVNSLATTFTGTSYYMAPERIQ 352
LH I+HRDIK NIL + G IKL DFG S + A S A + GT Y+MAPE I
Sbjct: 187 LHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVIL 246
Query: 353 GQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGI 412
+S ++D+WS+G T++E+ G +P+ + I + I T K P
Sbjct: 247 QTGHSFSADIWSVGCTVIEMVTGKAPW-----SQQYKEIAAIFHIGT----TKSHPPIPD 297
Query: 413 VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPW-----MVGQTKKHVNMKKFIQTC 462
S FL L+++ RP+ ++L+ W ++ ++++ +K + C
Sbjct: 298 NISSDANDFLLKCLQQEPNLRPTASELLKVKWSTDIHLLRANRRNLRLKILLHLC 352
>At1g32320 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 305
Score = 108 bits (271), Expect = 1e-23
Identities = 92/317 (29%), Positives = 141/317 (44%), Gaps = 31/317 (9%)
Query: 135 EPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVT 194
EP T S L+ HG + S+ E+ QT ++ L +LG+G+GG+V
Sbjct: 11 EPLTLSIPPLIYHGTAFSVAS----SSSSSPETSPIQTLN---DLEKLSVLGQGSGGTVY 63
Query: 195 KCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFI 254
K + R ++ALK + N + E K +S FI++ Y +F +
Sbjct: 64 KTRHRRTKTLYALKVLRPNLNT----TVTVEADILKRIESSFIIKCYAVFV--SLYDLCF 117
Query: 255 AMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILF 314
ME M SL L E ++ +A +L+GL YL + I+H DIKP N+L
Sbjct: 118 VMELMEKGSLHDA----LLAQQVFSEPMVSSLANRILQGLRYLQKMGIVHGDIKPSNLLI 173
Query: 315 NEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQ------GQPYSVTSDVWSLGLT 368
N+ G++K+ DFG S V GT YM+PER+ G DVWSLG+
Sbjct: 174 NKKGEVKIADFGAS-RIVAGGDYGSNGTCAYMSPERVDLEKWGFGGEVGFAGDVWSLGVV 232
Query: 369 LLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKK 428
+LE G P + P L + E D P + S F+ F+ L+K
Sbjct: 233 VLECYIGRYPLTK---VGDKPDWATLFCAICCN-EKVDIP---VSCSLEFRDFVGRCLEK 285
Query: 429 DSKDRPSPRQMLQHPWM 445
D + R + ++L+H ++
Sbjct: 286 DWRKRDTVEELLRHSFV 302
>YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 655
Score = 108 bits (270), Expect = 2e-23
Identities = 79/243 (32%), Positives = 119/243 (48%), Gaps = 20/243 (8%)
Query: 206 ALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLD 265
A+K I E ++ I EL + + IV + + ++ +++ MEYM G L
Sbjct: 404 AIKQIRLSEQP-KKQLIMNELLVMNDSRQENIVNFLEAYIIDDEE-LWVIMEYMEGGCLT 461
Query: 266 SVYKHLLSKG-----GRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQI 320
+ + + E + I + +GL +LH +KIIHRDIK NIL N G +
Sbjct: 462 DILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLV 521
Query: 321 KLCDFGVSGEAV--NSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSP 378
K+ DFG E S T GT Y+MAPE + + Y DVWSLG+ L+E+ +G P
Sbjct: 522 KITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPP 581
Query: 379 FDTDKLAANMPPIELLMLIL-TFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPR 437
+ N P++ L LI +P+L+ PE SK K FLD L+ + + R S R
Sbjct: 582 Y------LNEDPLKALYLIANNGSPKLR-HPES---VSKQTKQFLDACLQVNVESRASVR 631
Query: 438 QML 440
++L
Sbjct: 632 KLL 634
>Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 370
Score = 108 bits (270), Expect = 2e-23
Identities = 88/300 (29%), Positives = 144/300 (47%), Gaps = 19/300 (6%)
Query: 165 LESDIW-QTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIF 223
+E W Q I + D +LG G V + + K+ A+K IA +G E +
Sbjct: 5 VEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME 64
Query: 224 RELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVL 283
E+ K IV ++ E +++ M+ + G L + ++ KG E+
Sbjct: 65 NEIAVLHKIKHPNIVALDDIY--ESGGHLYLIMQLVSGGEL---FDRIVEKGFYT-ERDA 118
Query: 284 GKIAESVLRGLFYLHERKIIHRDIKPQNILF---NEIGQIKLCDFGVSG-EAVNSLATTF 339
++ VL + YLH+ I+HRD+KP+N+L+ +E +I + DFG+S E S+ +T
Sbjct: 119 SRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTA 178
Query: 340 TGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT 399
GT Y+APE + +PYS D WS+G+ + G+ PF + A +L IL
Sbjct: 179 CGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDA------KLFEQILK 232
Query: 400 FTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFI 459
E D P + S S K F+ + ++KD + R + Q LQHPW+ G T N+ + +
Sbjct: 233 AEYEF-DSPYWDDI-SDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSV 290
>CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 378
Score = 108 bits (269), Expect = 2e-23
Identities = 72/264 (27%), Positives = 123/264 (46%), Gaps = 21/264 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+G G G+V + + + A+K +A + ++ + E++ K + +V Y +
Sbjct: 114 IGVGASGTVFVANVAGSTDVVAVKRMA-FKTQPKKEMLLTEIKVMKQYRHPNLVNYIESY 172
Query: 245 ACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ +++ M+Y+ GG D V K L +G + + + L+ L +LH I+
Sbjct: 173 LVD-ADDLWVVMDYLEGGNLTDVVVKTELDEGQ------IAAVLQECLKALHFLHRHSIV 225
Query: 304 HRDIKPQNILFNEIGQIKLCDFGVSGE-AVNSLATTFTGTSYYMAPERIQGQPYSVTSDV 362
HRDIK N+L G++KL D G + S T GT Y+M+PE + + Y+ D+
Sbjct: 226 HRDIKSDNVLLGMNGEVKLTDMGFCAQIQPGSKRDTVVGTPYWMSPEILNKKQYNYKVDI 285
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLIL-TFTPELKDEPEQGIVWSKSFKSF 421
WSLG+ LE+ G P+ P++ + LI PE+K S F +F
Sbjct: 286 WSLGIMALEMIDGEPPY------LRETPLKAIYLIAQNGKPEIKQRDR----LSSEFNNF 335
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWM 445
LD L D R ++L HP++
Sbjct: 336 LDKCLVVDPDQRADTTELLAHPFL 359
>CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 336
Score = 108 bits (269), Expect = 2e-23
Identities = 90/298 (30%), Positives = 137/298 (45%), Gaps = 34/298 (11%)
Query: 175 IHEQIDTLGILGEGTGGSV---------TKC--KLRNGSKI---FALKTIATIENDGSEK 220
I +Q + I+G+G SV TKC K+R S + F K +E
Sbjct: 53 IEKQYEIGAIIGKGNFSSVHLTRRKEDGTKCALKVRYQSTLQFSFPSKFFQQVEKRAMRG 112
Query: 221 QIF---RELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGR 277
+ F E++ + D I+ F+ E + FI E+ +Y+ + K GR
Sbjct: 113 KCFFVDNEVEMLSLIQHDHIISIIDAFSTE--NQYFIVFEHA---QYGDLYE-TIRKNGR 166
Query: 278 IGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLAT 337
I E I V L YLHER ++HRD+KP+N+L + +KLCDFG++ + L
Sbjct: 167 IEEPDAAIITLQVASALNYLHERNVVHRDVKPENLLLVDKFSVKLCDFGLACHILGPL-Y 225
Query: 338 TFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI 397
GT Y APE ++ YS D+WSLG+ L + G++PF L LI
Sbjct: 226 RICGTPTYCAPEVLRETGYSTRCDIWSLGVVLYVMLVGYAPFRAP------DQTRLFKLI 279
Query: 398 LTFTPELKDEPE-QGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVN 454
+ P L D PE +GI S K + + K + RP Q++ HPW+ T ++++
Sbjct: 280 MQAKPNL-DMPEWKGI--SLKAKDLVSRLMNKTEERRPLASQIMAHPWIAPYTMENID 334
>YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 821
Score = 107 bits (268), Expect = 3e-23
Identities = 82/282 (29%), Positives = 132/282 (46%), Gaps = 38/282 (13%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
++G+G +V K R K FA+K I+ + G+ + REL+ + IVR G
Sbjct: 203 VVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGF 262
Query: 244 FACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
+ E+T + ++ ME++ GG +D V H G +GE +I+ +L + Y+H I
Sbjct: 263 Y--EDTESYYMVMEFVSGGDLMDFVAAH-----GAVGEDAGREISRQILTAIKYIHSMGI 315
Query: 303 IHRDIKPQNILFNEIGQ--IKLCDFGVSGEAVN-SLATTFTGTSYYMAPERIQGQ----- 354
HRD+KP NIL + +K+ DFG++ N S TF GT Y+APE I+G+
Sbjct: 316 SHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVS 375
Query: 355 --------PYSVTSDVWSLGLTLLEVAQGHSPFD---TDKLAANMPPIELLMLILTFTPE 403
YS D+WS+G + + GH PF D+L +
Sbjct: 376 PDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIG-----------RGS 424
Query: 404 LKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ P + S+ + F+D L+ D +R + + L HPW+
Sbjct: 425 YHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466
>CE24761 [D] KOG0580 Serine/threonine protein kinase
Length = 305
Score = 107 bits (268), Expect = 3e-23
Identities = 74/275 (26%), Positives = 125/275 (44%), Gaps = 20/275 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYYG 242
LG+G GSV + + G A+K + + + + G E Q+ RE++ I++ Y
Sbjct: 36 LGKGKFGSVYLARTKTGHFHVAIKVLFKSQLISGGVEHQLEREIEIQSHLNHPNIIKLYT 95
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F + I++ +EY G + YK L + R E K + L Y H + +
Sbjct: 96 YFW--DAKKIYLVLEYAPGGEM---YKQL-TVSKRFSEPTAAKYMYEIADALSYCHRKNV 149
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDV 362
IHRDIKP+N+L G++K+ DFG S A ++ T GT Y+ PE + G +S D+
Sbjct: 150 IHRDIKPENLLIGSQGELKIGDFGWSVHAPSNKRQTMCGTMDYLPPEMVNGADHSDAVDL 209
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFL 422
W++G+ E G PF+ + + I+ T+ +K K + +
Sbjct: 210 WAIGVLCYEFLVGKPPFEHEDQSKTYAAIKAAR--FTYPDSVK----------KGARDLI 257
Query: 423 DYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKK 457
L D K R + Q+ +H W+ G + + +K
Sbjct: 258 GRLLVVDPKARCTLEQVKEHYWIQGMMEAKIRAEK 292
>At4g08500 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 107 bits (268), Expect = 3e-23
Identities = 92/340 (27%), Positives = 161/340 (47%), Gaps = 40/340 (11%)
Query: 115 QQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDE-LESDIWQTY 173
++ A+ M + I + D+ T S T+ N G S + + D WQ
Sbjct: 279 KEEEAEAEEMGARFIQLGDTADETCSFTT--NEGDSSSTVSNTSPIYPDGGAIITSWQKG 336
Query: 174 KIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCK 233
++ LG G+ GSV + +G FA+K ++ ++ ++ ++L+
Sbjct: 337 QL---------LGRGSFGSVYEGISGDGD-FFAVKEVSLLDQGSQAQECIQQLEGEIKLL 386
Query: 234 SDF----IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAES 289
S IVRY G ++ S ++I +E + SL +Y+ ++ + V+
Sbjct: 387 SQLQHQNIVRYRG--TAKDGSNLYIFLELVTQGSLLKLYQRY-----QLRDSVVSLYTRQ 439
Query: 290 VLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPE 349
+L GL YLH++ IHRDIK NIL + G +KL DFG++ + + + GT ++MAPE
Sbjct: 440 ILDGLKYLHDKGFIHRDIKCANILVDANGAVKLADFGLAKVSKFNDIKSCKGTPFWMAPE 499
Query: 350 ---RIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFT-PELK 405
R Y +D+WSLG T+LE+ G P+ +++ P++ L I T PE+
Sbjct: 500 VINRKDSDGYGSPADIWSLGCTVLEMCTGQIPY------SDLEPVQALFRIGRGTLPEVP 553
Query: 406 DEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
D S + F+ LK + ++RP+ ++L HP++
Sbjct: 554 D------TLSLDARLFILKCLKVNPEERPTAAELLNHPFV 587
>CE29092 [T] KOG0694 Serine/threonine protein kinase
Length = 707
Score = 107 bits (267), Expect = 4e-23
Identities = 72/258 (27%), Positives = 125/258 (47%), Gaps = 13/258 (5%)
Query: 131 MYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDI-WQTYKIHEQIDTLGILGEGT 189
M D+ S S++ N G +I E D ++ S + T IH+ + +LG+G+
Sbjct: 330 MTDTSTDISGSSNSENSGYLQQISEDDSGTTSSRSASKVPGGTLSIHD-FTFMKVLGKGS 388
Query: 190 GGSVTKCKLRNGSKIFALKTI---ATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFAC 246
G V + + +++A+K + +++D E + + + + K F+ + F
Sbjct: 389 FGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHSSF-- 446
Query: 247 EETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRD 306
+ + +F MEY+ G L + + + E A V L +LH +I+RD
Sbjct: 447 QTSDRLFFVMEYVNGGDL----MFQIQRARKFDESRARFYAAEVTCALQFLHRNDVIYRD 502
Query: 307 IKPQNILFNEIGQIKLCDFGVSGEAVN--SLATTFTGTSYYMAPERIQGQPYSVTSDVWS 364
+K NIL + G +L DFG+ E +N +L +TF GT Y+APE +Q Y V+ D W+
Sbjct: 503 LKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVSVDWWA 562
Query: 365 LGLTLLEVAQGHSPFDTD 382
LG+ + E+ G PF+ D
Sbjct: 563 LGVLMYEMMAGQPPFEAD 580
>CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 540
Score = 107 bits (267), Expect = 4e-23
Identities = 74/266 (27%), Positives = 125/266 (46%), Gaps = 27/266 (10%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+GEG+ G V + +I A+K + + + +F E+ + + IVR++
Sbjct: 255 IGEGSTGVVEAAYKISTKQIVAVKRM-NLRKQQRRELLFNEVSILRQYQHPNIVRFFSSH 313
Query: 245 ACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIH 304
++ +++ ME+M G SL + R+ E + I+ VL L +LH RK+IH
Sbjct: 314 LVDDE--LWVVMEFMEGGSLTDIVT-----ATRMTEPQIATISRQVLGALDFLHARKVIH 366
Query: 305 RDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQGQPYSVTSDV 362
RDIK +IL G +KL DFG G+ + + GT Y+ A E I +PY +D+
Sbjct: 367 RDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADI 426
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE----QGIVWSKSF 418
WS G+ L+E+ +G PF D+ P + + ++DE E + S
Sbjct: 427 WSFGIMLIEMVEGEPPFFNDQ------PFQAM-------KRIRDEHEARFSRHAKVSVEL 473
Query: 419 KSFLDYSLKKDSKDRPSPRQMLQHPW 444
L + + KD R + +L+HP+
Sbjct: 474 SELLSHCIVKDVNKRWPAKDLLRHPF 499
>CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 542
Score = 107 bits (267), Expect = 4e-23
Identities = 74/266 (27%), Positives = 125/266 (46%), Gaps = 27/266 (10%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
+GEG+ G V + +I A+K + + + +F E+ + + IVR++
Sbjct: 257 IGEGSTGVVEAAYKISTKQIVAVKRM-NLRKQQRRELLFNEVSILRQYQHPNIVRFFSSH 315
Query: 245 ACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIH 304
++ +++ ME+M G SL + R+ E + I+ VL L +LH RK+IH
Sbjct: 316 LVDDE--LWVVMEFMEGGSLTDIVT-----ATRMTEPQIATISRQVLGALDFLHARKVIH 368
Query: 305 RDIKPQNILFNEIGQIKLCDFGVSGEAVNSL--ATTFTGTSYYMAPERIQGQPYSVTSDV 362
RDIK +IL G +KL DFG G+ + + GT Y+ A E I +PY +D+
Sbjct: 369 RDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADI 428
Query: 363 WSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE----QGIVWSKSF 418
WS G+ L+E+ +G PF D+ P + + ++DE E + S
Sbjct: 429 WSFGIMLIEMVEGEPPFFNDQ------PFQAM-------KRIRDEHEARFSRHAKVSVEL 475
Query: 419 KSFLDYSLKKDSKDRPSPRQMLQHPW 444
L + + KD R + +L+HP+
Sbjct: 476 SELLSHCIVKDVNKRWPAKDLLRHPF 501
>YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 380
Score = 107 bits (266), Expect = 5e-23
Identities = 70/215 (32%), Positives = 112/215 (51%), Gaps = 22/215 (10%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIAT--------IENDGSEKQIFR 224
Y +H+ + LG G+ G V + + + +A+K + +E+ E+++
Sbjct: 65 YTLHD-FQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRML- 122
Query: 225 ELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLG 284
K + F++R +G F ++ IF+ M+Y+ G L S LL K R V
Sbjct: 123 -----KLVEHPFLIRMWGTF--QDARNIFMVMDYIEGGELFS----LLRKSQRFPNPVAK 171
Query: 285 KIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSY 344
A V+ L YLH II+RD+KP+NIL + G IK+ DFG + E V ++ T GT
Sbjct: 172 FYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKE-VQTVTWTLCGTPD 230
Query: 345 YMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF 379
Y+APE I +PY+ + D WSLG+ + E+ G++PF
Sbjct: 231 YIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPF 265
>Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 357
Score = 107 bits (266), Expect = 5e-23
Identities = 81/279 (29%), Positives = 133/279 (47%), Gaps = 18/279 (6%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
LG G V + + K+FA+K I G E I E+ + K + IV ++
Sbjct: 29 LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIY 88
Query: 245 ACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIH 304
E + +++ M+ + G L + ++ KG EK + VL ++YLH I+H
Sbjct: 89 --ESPNHLYLVMQLVSGGEL---FDRIVEKGFYT-EKDASTLIRQVLDAVYYLHRMGIVH 142
Query: 305 RDIKPQNILF---NEIGQIKLCDFGVSG-EAVNSLATTFTGTSYYMAPERIQGQPYSVTS 360
RD+KP+N+L+ +E +I + DFG+S E + +T GT Y+APE + +PYS
Sbjct: 143 RDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAV 202
Query: 361 DVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKS 420
D WS+G+ + G+ PF + +L IL E D P + S S K
Sbjct: 203 DCWSIGVIAYILLCGYPPFYDEN------DSKLFEQILKAEYEF-DSPYWDDI-SDSAKD 254
Query: 421 FLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMKKFI 459
F+ ++KD R + Q +HPW+ G T + N+ + +
Sbjct: 255 FIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESV 293
>Hs16950621 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 992
Score = 107 bits (266), Expect = 5e-23
Identities = 97/327 (29%), Positives = 149/327 (44%), Gaps = 25/327 (7%)
Query: 134 SEPTTSSSTSLVNHGKESEIIEHD-RDDSTDELESD-----IWQTYKIHEQIDTLGILGE 187
SEP+ S + V E E + DD E E D I K+ + D LG
Sbjct: 491 SEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGS 550
Query: 188 GTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACE 247
G G V + + K++A K E I +E+ +V+ F E
Sbjct: 551 GKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKEN-IRQEISIMNCLHHPKLVQCVDAF--E 607
Query: 248 ETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDI 307
E + I + +E + G L ++ ++ + + E+ K + G+ Y+H++ I+H D+
Sbjct: 608 EKANIVMVLEIVSGGEL---FERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDL 664
Query: 308 KPQNIL-FNEIG-QIKLCDFGVSGEAVN--SLATTFTGTSYYMAPERIQGQPYSVTSDVW 363
KP+NI+ N+ G +IKL DFG++ N SL F GT ++APE I +P +D+W
Sbjct: 665 KPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLF-GTPEFVAPEVINYEPIGYATDMW 723
Query: 364 SLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLD 423
S+G+ + G SPF D E L + + T + DE I S K F+
Sbjct: 724 SIGVICYILVSGLSPFMGDN------DNETLANVTSATWDFDDEAFDEI--SDDAKDFIS 775
Query: 424 YSLKKDSKDRPSPRQMLQHPWMVGQTK 450
LKKD K+R Q LQHPW++ TK
Sbjct: 776 NLLKKDMKNRLDCTQCLQHPWLMKDTK 802
>Hs16950613 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 1845
Score = 107 bits (266), Expect = 5e-23
Identities = 97/327 (29%), Positives = 149/327 (44%), Gaps = 25/327 (7%)
Query: 134 SEPTTSSSTSLVNHGKESEIIEHD-RDDSTDELESD-----IWQTYKIHEQIDTLGILGE 187
SEP+ S + V E E + DD E E D I K+ + D LG
Sbjct: 1344 SEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGS 1403
Query: 188 GTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACE 247
G G V + + K++A K E I +E+ +V+ F E
Sbjct: 1404 GKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKEN-IRQEISIMNCLHHPKLVQCVDAF--E 1460
Query: 248 ETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDI 307
E + I + +E + G L ++ ++ + + E+ K + G+ Y+H++ I+H D+
Sbjct: 1461 EKANIVMVLEIVSGGEL---FERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDL 1517
Query: 308 KPQNIL-FNEIG-QIKLCDFGVSGEAVN--SLATTFTGTSYYMAPERIQGQPYSVTSDVW 363
KP+NI+ N+ G +IKL DFG++ N SL F GT ++APE I +P +D+W
Sbjct: 1518 KPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLF-GTPEFVAPEVINYEPIGYATDMW 1576
Query: 364 SLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLD 423
S+G+ + G SPF D E L + + T + DE I S K F+
Sbjct: 1577 SIGVICYILVSGLSPFMGDN------DNETLANVTSATWDFDDEAFDEI--SDDAKDFIS 1628
Query: 424 YSLKKDSKDRPSPRQMLQHPWMVGQTK 450
LKKD K+R Q LQHPW++ TK
Sbjct: 1629 NLLKKDMKNRLDCTQCLQHPWLMKDTK 1655
>Hs16950611 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 1914
Score = 107 bits (266), Expect = 5e-23
Identities = 97/327 (29%), Positives = 149/327 (44%), Gaps = 25/327 (7%)
Query: 134 SEPTTSSSTSLVNHGKESEIIEHD-RDDSTDELESD-----IWQTYKIHEQIDTLGILGE 187
SEP+ S + V E E + DD E E D I K+ + D LG
Sbjct: 1413 SEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGS 1472
Query: 188 GTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACE 247
G G V + + K++A K E I +E+ +V+ F E
Sbjct: 1473 GKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKEN-IRQEISIMNCLHHPKLVQCVDAF--E 1529
Query: 248 ETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDI 307
E + I + +E + G L ++ ++ + + E+ K + G+ Y+H++ I+H D+
Sbjct: 1530 EKANIVMVLEIVSGGEL---FERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDL 1586
Query: 308 KPQNIL-FNEIG-QIKLCDFGVSGEAVN--SLATTFTGTSYYMAPERIQGQPYSVTSDVW 363
KP+NI+ N+ G +IKL DFG++ N SL F GT ++APE I +P +D+W
Sbjct: 1587 KPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLF-GTPEFVAPEVINYEPIGYATDMW 1645
Query: 364 SLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLD 423
S+G+ + G SPF D E L + + T + DE I S K F+
Sbjct: 1646 SIGVICYILVSGLSPFMGDN------DNETLANVTSATWDFDDEAFDEI--SDDAKDFIS 1697
Query: 424 YSLKKDSKDRPSPRQMLQHPWMVGQTK 450
LKKD K+R Q LQHPW++ TK
Sbjct: 1698 NLLKKDMKNRLDCTQCLQHPWLMKDTK 1724
>Hs16950601 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 991
Score = 107 bits (266), Expect = 5e-23
Identities = 97/327 (29%), Positives = 149/327 (44%), Gaps = 25/327 (7%)
Query: 134 SEPTTSSSTSLVNHGKESEIIEHD-RDDSTDELESD-----IWQTYKIHEQIDTLGILGE 187
SEP+ S + V E E + DD E E D I K+ + D LG
Sbjct: 491 SEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGS 550
Query: 188 GTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACE 247
G G V + + K++A K E I +E+ +V+ F E
Sbjct: 551 GKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKEN-IRQEISIMNCLHHPKLVQCVDAF--E 607
Query: 248 ETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDI 307
E + I + +E + G L ++ ++ + + E+ K + G+ Y+H++ I+H D+
Sbjct: 608 EKANIVMVLEIVSGGEL---FERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDL 664
Query: 308 KPQNIL-FNEIG-QIKLCDFGVSGEAVN--SLATTFTGTSYYMAPERIQGQPYSVTSDVW 363
KP+NI+ N+ G +IKL DFG++ N SL F GT ++APE I +P +D+W
Sbjct: 665 KPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLF-GTPEFVAPEVINYEPIGYATDMW 723
Query: 364 SLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLD 423
S+G+ + G SPF D E L + + T + DE I S K F+
Sbjct: 724 SIGVICYILVSGLSPFMGDN------DNETLANVTSATWDFDDEAFDEI--SDDAKDFIS 775
Query: 424 YSLKKDSKDRPSPRQMLQHPWMVGQTK 450
LKKD K+R Q LQHPW++ TK
Sbjct: 776 NLLKKDMKNRLDCTQCLQHPWLMKDTK 802
>At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 594
Score = 107 bits (266), Expect = 5e-23
Identities = 86/317 (27%), Positives = 150/317 (47%), Gaps = 24/317 (7%)
Query: 135 EPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVT 194
EP S +V+HG +S +R D + Y++ +++ G G
Sbjct: 107 EPIPEDSEDVVDHGGDSG--GGERLDKNFGFGKNFEGKYELGKEVGR-GHFGHTCWAKAK 163
Query: 195 KCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSD-FIVRYYGMFACEETSTIF 253
K K++N + + + A + + S + + RE++ K+ +V++Y ++ E+ +F
Sbjct: 164 KGKMKNQTVAVKIISKAKMTSTLSIEDVRREVKLLKALSGHRHMVKFYDVY--EDADNVF 221
Query: 254 IAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNI 312
+ ME GG LD + L++GGR E +I +L + H + ++HRD+KP+N
Sbjct: 222 VVMELCEGGELLDRI----LARGGRYPEVDAKRILVQILSATAFFHLQGVVHRDLKPENF 277
Query: 313 LF---NEIGQIKLCDFGVSG-EAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLT 368
LF NE +K+ DFG+S + G++YY+APE + + YS +D+WS+G+
Sbjct: 278 LFTSRNEDAILKVIDFGLSDFIRYDQRLNDVVGSAYYVAPE-VLHRSYSTEADMWSIGVI 336
Query: 369 LLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKK 428
+ G PF +A + +L P +D P I S + K F+ L K
Sbjct: 337 SYILLCGSRPFYGRTESA------IFRCVLRANPNFEDMPWPSI--SPTAKDFVKRLLNK 388
Query: 429 DSKDRPSPRQMLQHPWM 445
D + R + Q L HPW+
Sbjct: 389 DHRKRMTAAQALAHPWL 405
>YHR205w [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 824
Score = 106 bits (265), Expect = 6e-23
Identities = 75/221 (33%), Positives = 117/221 (52%), Gaps = 21/221 (9%)
Query: 171 QTYKIH---EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIAT--------IENDGSE 219
QT K H + + L +LG+GT G V + K ++ +I+A+K ++ I + E
Sbjct: 401 QTKKRHYGPQDFEVLRLLGKGTFGQVYQVKKKDTQRIYAMKVLSKKVIVKKNEIAHTIGE 460
Query: 220 KQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIG 279
+ I L S S FIV F+ + + +++ +YM G L + HL +G
Sbjct: 461 RNI---LVTTASKSSPFIVGL--KFSFQTPTDLYLVTDYMSGGEL---FWHLQKEGRFSE 512
Query: 280 EKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTF 339
++ IAE VL L +LH+ I++RD+KP+NIL + G I LCDFG+S + TF
Sbjct: 513 DRAKFYIAELVL-ALEHLHDNDIVYRDLKPENILLDANGNIALCDFGLSKADLKDRTNTF 571
Query: 340 TGTSYYMAPERIQGQP-YSVTSDVWSLGLTLLEVAQGHSPF 379
GT+ Y+APE + + Y+ D WSLG+ + E+ G SPF
Sbjct: 572 CGTTEYLAPELLLDETGYTKMVDFWSLGVLIFEMCCGWSPF 612
>Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 493
Score = 106 bits (265), Expect = 6e-23
Identities = 65/210 (30%), Positives = 111/210 (51%), Gaps = 10/210 (4%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQI-FRELQFNKSCKSD 235
E+ + LG++GEG+ G V KC+ ++ +I A+K ++D K+I RE++ K + +
Sbjct: 2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
+V + C++ ++ E++ LD + L G + +V+ K ++ G+
Sbjct: 62 NLVNL--LEVCKKKKRWYLVFEFVDHTILDDL--ELFPNG--LDYQVVQKYLFQIINGIG 115
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFTGTSYYMAPERIQG 353
+ H IIHRDIKP+NIL ++ G +KLCDFG + A + T + T +Y APE + G
Sbjct: 116 FCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVG 175
Query: 354 Q-PYSVTSDVWSLGLTLLEVAQGHSPFDTD 382
Y DVW++G + E+ G F D
Sbjct: 176 DVKYGKAVDVWAIGCLVTEMFMGEPLFPGD 205
>Hs22065797 [T] KOG0577 Serine/threonine protein kinase
Length = 897
Score = 106 bits (265), Expect = 6e-23
Identities = 75/203 (36%), Positives = 110/203 (53%), Gaps = 23/203 (11%)
Query: 256 MEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFN 315
MEY G + D + H + E + I L+GL YLH +IHRDIK NIL
Sbjct: 1 MEYCLGSASDLLEVHKKP----LQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLT 56
Query: 316 EIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERI----QGQPYSVTSDVWSLGLTLLE 371
E GQ+KL DFG + A S A +F GT Y+MAPE I +GQ Y DVWSLG+T +E
Sbjct: 57 EPGQVKLADFGSASMA--SPANSFVGTPYWMAPEVILAMDEGQ-YDGKVDVWSLGITCIE 113
Query: 372 VAQGHSP-FDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDS 430
+A+ P F+ + ++A L + +P L Q WS F++F+D L+K
Sbjct: 114 LAERKPPLFNMNAMSA------LYHIAQNESPTL-----QSNEWSDYFRNFVDSCLQKIP 162
Query: 431 KDRPSPRQMLQHPWMVGQTKKHV 453
+DRP+ ++L+H +++ + + V
Sbjct: 163 QDRPTSEELLKHIFVLRERPETV 185
>CE18169 [T] KOG0603 Ribosomal protein S6 kinase
Length = 797
Score = 106 bits (264), Expect = 8e-23
Identities = 90/306 (29%), Positives = 147/306 (47%), Gaps = 33/306 (10%)
Query: 89 GSAMGSLSNKLHGLKINTDHLPTSGSQQSTQSADSMTSNLI--SMYDSEPTTSSSTSLVN 146
G S+ N G+ DH + S T+N S++ +P ++ L+N
Sbjct: 17 GITPSSIENVSPGIDQCKDHRMDVSMRSDPTDCSSDTTNTFHSSIHIIQPPPNNGFRLMN 76
Query: 147 HGKESEIIEHDRDDSTDELESDIWQTYKIHE-----QIDTLGILGEGTGGSV---TKCKL 198
+ DS+ E E DI K E Q + L +LG+G+ G V K +
Sbjct: 77 W----------KTDSSSETEIDIGDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRG 126
Query: 199 RNGSKIFALKTI--ATIE-NDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIA 255
R+ ++A+K + AT++ D ++ R + + S FIV+ + F E +++
Sbjct: 127 RDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHIS--HPFIVKLHYAFQTE--GKLYLI 182
Query: 256 MEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFN 315
++++ G L + LSK E + + L +LH I++RD+KP+NIL +
Sbjct: 183 LDFLRGGDLFT----RLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLD 238
Query: 316 EIGQIKLCDFGVSGEAVNSLATT--FTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVA 373
G IK+ DFG+S EA++S T F GT YMAPE I + +S+ +D WSLG+ + E+
Sbjct: 239 ADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEML 298
Query: 374 QGHSPF 379
GH PF
Sbjct: 299 TGHLPF 304
Score = 87.8 bits (216), Expect = 3e-17
Identities = 75/288 (26%), Positives = 133/288 (46%), Gaps = 29/288 (10%)
Query: 171 QTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNK 230
+T + + L +G G V KC+++ + +A+K + D +E+ +
Sbjct: 446 KTNPFTDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDI----LLR 501
Query: 231 SCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESV 290
F+V+ + ++ +ET+ I GG LD L++K EK + I ++
Sbjct: 502 HSHHQFVVKLFDVYE-DETAIYMIEELCEGGELLDK----LVNKKSLGSEKEVAAIMANL 556
Query: 291 LRGLFYLHERKIIHRDIKPQNILF----NEIGQIKLCDFGVSGE--AVNSLATTFTGTSY 344
L + YLH +++ HRD+ NILF + +++ DFG + + A N + T T+
Sbjct: 557 LNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQ 616
Query: 345 YMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI----LTF 400
++APE ++ Q Y + DVWSLG+ L + G +PF + N P ++L + ++
Sbjct: 617 FVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPF---AMGPNDTPDQILQRVGDGKISM 673
Query: 401 TPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
T + D S K + L D R + +Q LQH W +GQ
Sbjct: 674 THPVWD------TISDEAKDLVRKMLDVDPNRRVTAKQALQHKW-IGQ 714
>CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 348
Score = 105 bits (263), Expect = 1e-22
Identities = 77/283 (27%), Positives = 141/283 (49%), Gaps = 26/283 (9%)
Query: 175 IHEQIDTLGILGEGTGGSVTKCKLRNGS-KIFALKTIATIENDGSEKQIFRELQFNKSCK 233
I E+ D +LG G V + ++ + +++A+K I G E+ + E++ + +
Sbjct: 18 IREKYDFRDVLGTGAFSKVFLAESKSDAGQMYAVKCIDKKALKGKEESLENEIKVLRKLR 77
Query: 234 SDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRG 293
+ IV+ + + +E +++ ME + G L + +++KG E+ + VL
Sbjct: 78 HNNIVQLFDTY--DEKQFVYLVMELVTGGEL---FDRIVAKGSYT-EQDASNLIRQVLEA 131
Query: 294 LFYLHERKIIHRDIKPQNILF---NEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPER 350
+ ++H+ ++HRD+KP+N+L+ +E +I + DFG+S + + T GT Y+APE
Sbjct: 132 VGFMHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGLSKTEDSGVMATACGTPGYVAPEV 191
Query: 351 IQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPE- 409
+Q +PY DVWS+G+ + G+ PF D+ AN+ F +K E E
Sbjct: 192 LQQKPYGKAVDVWSIGVIAYILLCGYPPF-YDESDANL-----------FAQIIKGEYEF 239
Query: 410 QGIVW---SKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQT 449
W S S K F+ + + D + R + + L HPW+ G T
Sbjct: 240 DAPYWDQISDSAKDFITHLMCCDPEARFTCQDALSHPWISGNT 282
>At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 546
Score = 105 bits (263), Expect = 1e-22
Identities = 95/350 (27%), Positives = 169/350 (48%), Gaps = 36/350 (10%)
Query: 114 SQQSTQSA-DSMTSNLISMYDSEPTTSSSTSLVNHGKES-EIIEHDRD---DSTDELESD 168
SQ+ T D+++ ++ + D + S S H K S E+I + D TDE E D
Sbjct: 223 SQEETDGLRDALSKEILKLKDQPGSKQKSISFFEHDKSSNELIPACIEIPTDGTDEWEID 282
Query: 169 IWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQF 228
+ Q KI +++ + G G+ G T C K + N+ ++ +E+
Sbjct: 283 VTQL-KIEKKVAS-GSYGDLHRG--TYCSQEVAIKFLKPDRV----NNEMLREFSQEVFI 334
Query: 229 NKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAE 288
+ + +V++ G AC + T+ I E+M + S+Y L + + L K+A
Sbjct: 335 MRKVRHKNVVQFLG--ACTRSPTLCIVTEFM---ARGSIYDFLHKQKCAFKLQTLLKVAL 389
Query: 289 SVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS-LATTFTGTSYYMA 347
V +G+ YLH+ IIHRD+K N+L +E G +K+ DFGV+ + S + T TGT +MA
Sbjct: 390 DVAKGMSYLHQNNIIHRDLKTANLLMDEHGLVKVADFGVARVQIESGVMTAETGTYRWMA 449
Query: 348 PERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILT--FTPELK 405
PE I+ +PY+ +DV+S + L E+ G P+ A + P++ + ++ P++
Sbjct: 450 PEVIEHKPYNHKADVFSYAIVLWELLTGDIPY------AFLTPLQAAVGVVQKGLRPKIP 503
Query: 406 DEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNM 455
+ + K L+ +D + RP ++++ M+ Q K VN+
Sbjct: 504 KKTHPKV------KGLLERCWHQDPEQRPLFEEIIE---MLQQIMKEVNV 544
>7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 735
Score = 105 bits (263), Expect = 1e-22
Identities = 73/283 (25%), Positives = 133/283 (46%), Gaps = 24/283 (8%)
Query: 174 KIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSE-KQIFRELQFNKSC 232
K + + L ++G G+ G+ K + ++ ++FA K + E D ++ + E+ +
Sbjct: 14 KTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQL 73
Query: 233 KSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
+ IV+YY E +++I ME G L + + S+ R E + ++ + R
Sbjct: 74 QHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCR 133
Query: 293 GLFYLHER----KIIHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFTGTSYYM 346
L H + I+HRDIKP NI + G KL DFG++ S A +F GT +YM
Sbjct: 134 ALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYM 193
Query: 347 APERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF---DTDKLAANMPPIELLMLILTFTPE 403
+PE ++G+ Y SDVW++G + E+ PF D+L+ + E + ++ +
Sbjct: 194 SPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTD 253
Query: 404 LKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
L++ + + L D + RP +++HP +V
Sbjct: 254 LQE--------------IIAFMLAVDHEQRPGIEVIIRHPLVV 282
>Hs20070247_2 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 378
Score = 105 bits (263), Expect = 1e-22
Identities = 69/205 (33%), Positives = 106/205 (51%), Gaps = 11/205 (5%)
Query: 180 DTLGILGEGTGGSVTKCKLRNGSKIFALKTIAT--IENDGSEKQIFRELQ-FNKSCKSDF 236
D L ++G+G+ G V K + K++A+K + + N +K I E K+ K F
Sbjct: 45 DFLKVIGKGSFGKVLLAKRKLDGKVYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPF 104
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFY 296
+V + F + T ++ ++++ G L + HL + E A + L Y
Sbjct: 105 LVGLHYSF--QTTEKLYFVLDFVNGGEL---FFHL-QRERSFPEHRARFYAAEIASALGY 158
Query: 297 LHERKIIHRDIKPQNILFNEIGQIKLCDFGV--SGEAVNSLATTFTGTSYYMAPERIQGQ 354
LH KI++RD+KP+NIL + +G + L DFG+ G A++ TTF GT Y+APE I+ Q
Sbjct: 159 LHSIKIVYRDLKPENILVDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQ 218
Query: 355 PYSVTSDVWSLGLTLLEVAQGHSPF 379
PY T D W LG L E+ G PF
Sbjct: 219 PYDNTVDWWCLGAVLYEMLYGLPPF 243
>YJL095w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1478
Score = 105 bits (262), Expect = 1e-22
Identities = 83/294 (28%), Positives = 148/294 (50%), Gaps = 30/294 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF------- 236
++G+G+ G+V C ++ A+K + + + I ++ +S S
Sbjct: 1180 MIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLN 1239
Query: 237 IVRYYGMFACEETSTIF-IAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
IV+Y G E + I+ + +EY+ G S+ S L+ GR E ++ + VL+GL
Sbjct: 1240 IVQYLGF---ENKNNIYSLFLEYVAGGSVGS----LIRMYGRFDEPLIKHLTTQVLKGLA 1292
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLAT---TFTGTSYYMAPERIQ 352
YLH + I+HRD+K N+L ++ G K+ DFG+S ++ + + T GT ++MAPE +
Sbjct: 1293 YLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVD 1352
Query: 353 -GQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQG 411
Q YS D+WSLG +LE+ G P+ ++ A M + + PE
Sbjct: 1353 TKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVA-------AMFKIGKSKSAPPIPEDT 1405
Query: 412 I-VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM-VGQT--KKHVNMKKFIQT 461
+ + S+ ++FLD + + + RP+ ++L HP+ V +T K + KFI++
Sbjct: 1406 LPLISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETFNFKSTRLAKFIKS 1459
>At5g66850 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 376
Score = 105 bits (262), Expect = 1e-22
Identities = 75/275 (27%), Positives = 129/275 (46%), Gaps = 30/275 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSE----KQIFRELQFNKSCKSDFIVR 239
++G GT GSV + A+K + +D KQ+ +E++ + + IV+
Sbjct: 10 LIGRGTFGSVYVASNSETGALCAMKEVELFPDDPKSAECIKQLEQEIKLLSNLQHPNIVQ 69
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
Y+G E+ FI +EY+ S++ K++ G + E V+ +L GL YLH
Sbjct: 70 YFGSETVEDR--FFIYLEYVHPGSIN---KYIRDHCGTMTESVVRNFTRHILSGLAYLHN 124
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLA-TTFTGTSYYMAPE--------R 350
+K +HRDIK N+L + G +KL DFG++ A + G+ Y+MAPE +
Sbjct: 125 KKTVHRDIKGANLLVDASGVVKLADFGMAKHLTGQRADLSLKGSPYWMAPEVLMQAVMQK 184
Query: 351 IQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQ 410
+ D+WSLG T++E+ G P+ + AA M + ++D P
Sbjct: 185 DSNPDLAFAVDIWSLGCTIIEMFTGKPPWSEFEGAAAMFKV------------MRDSPPI 232
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
S K FL +++ +RP+ +L+H ++
Sbjct: 233 PESMSPEGKDFLRLCFQRNPAERPTASMLLEHRFL 267
>At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 487
Score = 105 bits (262), Expect = 1e-22
Identities = 79/282 (28%), Positives = 129/282 (45%), Gaps = 32/282 (11%)
Query: 185 LGEGTGGSVTKCK-LRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
+G G SV K + S + A+K I ++ + RE + I+ Y
Sbjct: 21 IGVGVSASVYKAICIPMNSMVVAIKAIDLDQSRADFDSLRRETKTMSLLSHPNILNAYCS 80
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
F + +++ M +M SL S+ G + E + + L + YLH++ +
Sbjct: 81 FTVDRC--LWVVMPFMSCGSLHSIVSSSFPSG--LPENCISVFLKETLNAISYLHDQGHL 136
Query: 304 HRDIKPQNILFNEIGQIKLCDFGV-----------SGEAVNSL-ATTFTGTSYYMAPERI 351
HRDIK NIL + G +KL DFGV SG +SL T GT Y+MAPE +
Sbjct: 137 HRDIKAGNILVDSDGSVKLADFGVSASIYEPVTSSSGTTSSSLRLTDIAGTPYWMAPEVV 196
Query: 352 QGQP-YSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKD---- 406
Y +D+WS G+T LE+A G P +++PP++ L++ +T D
Sbjct: 197 HSHTGYGFKADIWSFGITALELAHGRPPL------SHLPPLKSLLMKITKRFHFSDYEIN 250
Query: 407 ----EPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPW 444
+ +SK+F+ + L++D RPS ++L+HP+
Sbjct: 251 TSGSSKKGNKKFSKAFREMVGLCLEQDPTKRPSAEKLLKHPF 292
>7297776 [D] KOG0580 Serine/threonine protein kinase
Length = 329
Score = 105 bits (262), Expect = 1e-22
Identities = 76/277 (27%), Positives = 124/277 (44%), Gaps = 21/277 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYYG 242
LG G G V + R+ + A+K + + ++Q+ RE++ K I+R
Sbjct: 59 LGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLKHPHILRLLT 118
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLL-SKGGRIGEKVLGKIAESVLRGLFYLHERK 301
F + S I++A+E S ++KHL + R E K V L Y H
Sbjct: 119 WF--HDESRIYLALEIA---SEGELFKHLRGAPNHRFDEPRSAKYTYQVANALNYCHLNN 173
Query: 302 IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSD 361
+IHRD+KP+NIL +KL DFG S N+ T GT Y+ PE + G Y + D
Sbjct: 174 VIHRDLKPENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVD 233
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSF 421
W LG+ E G PF+++ + I + +++ L SK K
Sbjct: 234 QWCLGILCYEFVVGCPPFESNSTESTYSKIR--RMEISYPSHL----------SKGCKEL 281
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWM-VGQTKKHVNMKK 457
+ L+K+SK R + ++ H W+ G ++ + ++K
Sbjct: 282 IGGLLRKESKGRITLVDVMTHYWVKAGMAERELQLQK 318
>YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 398
Score = 105 bits (261), Expect = 2e-22
Identities = 68/200 (34%), Positives = 105/200 (52%), Gaps = 9/200 (4%)
Query: 182 LGILGEGTGGSVTKCKLRNGSKIFALKTIA--TIENDGSEKQIFRELQFNKSCKSDFIVR 239
L LG G+ G V + + + +ALKT+ TI + E + FI+R
Sbjct: 91 LRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIR 150
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
+G F +++ +F+ M+Y+ G L S LL K R V A V L YLH
Sbjct: 151 MWGTF--QDSQQVFMVMDYIEGGELFS----LLRKSQRFPNPVAKFYAAEVCLALEYLHS 204
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVT 359
+ II+RD+KP+NIL ++ G IK+ DFG + + V + T GT Y+APE + +PY+ +
Sbjct: 205 KDIIYRDLKPENILLDKNGHIKITDFGFA-KYVPDVTYTLCGTPDYIAPEVVSTKPYNKS 263
Query: 360 SDVWSLGLTLLEVAQGHSPF 379
D WS G+ + E+ G++PF
Sbjct: 264 VDWWSFGVLIYEMLAGYTPF 283
>Hs4759178 [D] KOG0580 Serine/threonine protein kinase
Length = 344
Score = 105 bits (261), Expect = 2e-22
Identities = 70/211 (33%), Positives = 107/211 (50%), Gaps = 11/211 (5%)
Query: 176 HEQIDTLGI---LGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNK 230
H ID I LG+G G+V + + I ALK + + IE +G E Q+ RE++
Sbjct: 71 HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQA 130
Query: 231 SCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESV 290
I+R Y F + I++ +EY L YK L K E+ I E +
Sbjct: 131 HLHHPNILRLYNYFY--DRRRIYLILEYAPRGEL---YKEL-QKSCTFDEQRTATIMEEL 184
Query: 291 LRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPER 350
L Y H +K+IHRDIKP+N+L G++K+ DFG S A + T GT Y+ PE
Sbjct: 185 ADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEM 244
Query: 351 IQGQPYSVTSDVWSLGLTLLEVAQGHSPFDT 381
I+G+ ++ D+W +G+ E+ G+ PF++
Sbjct: 245 IEGRMHNEKVDLWCIGVLCYELLVGNPPFES 275
>CE12518 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 391
Score = 105 bits (261), Expect = 2e-22
Identities = 88/335 (26%), Positives = 153/335 (45%), Gaps = 37/335 (11%)
Query: 123 SMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHD--RDDSTDELESDIWQTYKIHEQID 180
S SNL +P + T HG E + E RD +S + Y++
Sbjct: 19 SFFSNLFHKAHIDPHALAQTCPPPHGGEMPLGECAVLRDRPAMRFDSRLVCKYEV----- 73
Query: 181 TLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRY 240
L ++G+G+ V + + R K FA+K + +G + EL F++R
Sbjct: 74 -LAVVGKGSFSQVLRVQHRVTRKYFAVKVV-----NGDCGAVNNELNILSRLSHPFVIRL 127
Query: 241 YGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
+F + +S +FI M+ G + Y +++KG R E+ + +L GL YLH
Sbjct: 128 EEVF--KSSSKLFIVMQMASGGEM---YDRVVAKG-RYSEEEARNALKMLLTGLTYLHSI 181
Query: 301 KIIHRDIKPQNILFNEI---GQIKLCDFGVSGEAV--NSLATTFTGTSYYMAPERIQGQP 355
++ HRD+KP+N+L+ + ++ + DFG++ +A N T GT Y+APE + P
Sbjct: 182 RVTHRDLKPENLLYADSRPEARLLITDFGLAYQATKPNETMTETCGTPEYIAPELLLRVP 241
Query: 356 YSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWS 415
Y+ D+W++G+ + G PFD D + ++ + P+ WS
Sbjct: 242 YTQKVDMWAVGVIAYILMSGIMPFDDD--CRSRLYTHIITANYVYYPQF---------WS 290
Query: 416 KS--FKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
S K F+D L+ +S +R S ++H W+ G+
Sbjct: 291 GSELAKQFVDSLLETNSVERLSSSAAMKHEWLTGE 325
>CE23001 [R] KOG0589 Serine/threonine protein kinase
Length = 579
Score = 104 bits (260), Expect = 2e-22
Identities = 82/312 (26%), Positives = 138/312 (43%), Gaps = 27/312 (8%)
Query: 141 STSLVNHGKESEIIEHDRDDSTDELESDIWQTY------KIHEQIDTLGILGEGTGGSVT 194
S LV+ SE+ H+R + ++I T + + + +G+G GS
Sbjct: 127 SVRLVSRFLSSELAPHNRRIVEIYINNEIMITNPNPRATSAQNRYERIRTVGKGAFGSAV 186
Query: 195 KCKLRNGSKIFALKTIATIENDGSEKQI-FRELQFNKSCKSDFIVRYYGMFACEETSTIF 253
+ R S + +K I + D S++++ E+ + I+ YY F EE +
Sbjct: 187 LYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSF--EEEGVLM 244
Query: 254 IAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNIL 313
I MEY G +L + L + E+ +G + + + YLHE ++HRD+K N+
Sbjct: 245 IEMEYADGGTLAQM---LSRTQNLLDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVF 301
Query: 314 FNEIGQIKLCDFGVSG----EAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTL 369
+K+ DFG+S E + A T GT YY++PE G Y+ SD+W+LG L
Sbjct: 302 LTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCIL 361
Query: 370 LEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKD 429
E+ F+ D N+P + ++ +TP +S K + L+ D
Sbjct: 362 YEMCCLKKAFEGD----NLPALVNSIMTCAYTPVKGP-------YSAEMKMVIRELLQLD 410
Query: 430 SKDRPSPRQMLQ 441
+ RPS Q L+
Sbjct: 411 PQKRPSAPQALK 422
>CE13014 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 104 bits (260), Expect = 2e-22
Identities = 80/244 (32%), Positives = 130/244 (52%), Gaps = 22/244 (9%)
Query: 150 ESEIIE-HDRDDSTDELESDIWQTYKIHE-----QIDTLGILGEGTGGSV---TKCKLRN 200
E+EI + ++ DS+ E E DI K E Q + L +LG+G+ G V K + R+
Sbjct: 12 ENEIEQGEEKTDSSSETEIDIGDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRD 71
Query: 201 GSKIFALKTI--ATIE-NDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAME 257
++A+K + AT++ D ++ R + + S FIV+ + F E +++ ++
Sbjct: 72 SGHVYAMKVLKKATLKVRDRQRTKLERNILAHIS--HPFIVKLHYAFQTE--GKLYLILD 127
Query: 258 YMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEI 317
++ G L + LSK E + + L +LH I++RD+KP+NIL +
Sbjct: 128 FLRGGDLFT----RLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDAD 183
Query: 318 GQIKLCDFGVSGEAVNSLATT--FTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQG 375
G IK+ DFG+S EA++S T F GT YMAPE I + +S+ +D WSLG+ + E+ G
Sbjct: 184 GHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTG 243
Query: 376 HSPF 379
H PF
Sbjct: 244 HLPF 247
Score = 87.8 bits (216), Expect = 3e-17
Identities = 75/288 (26%), Positives = 133/288 (46%), Gaps = 29/288 (10%)
Query: 171 QTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNK 230
+T + + L +G G V KC+++ + +A+K + D +E+ +
Sbjct: 389 KTNPFTDDYEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDI----LLR 444
Query: 231 SCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESV 290
F+V+ + ++ +ET+ I GG LD L++K EK + I ++
Sbjct: 445 HSHHQFVVKLFDVYE-DETAIYMIEELCEGGELLDK----LVNKKSLGSEKEVAAIMANL 499
Query: 291 LRGLFYLHERKIIHRDIKPQNILF----NEIGQIKLCDFGVSGE--AVNSLATTFTGTSY 344
L + YLH +++ HRD+ NILF + +++ DFG + + A N + T T+
Sbjct: 500 LNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQ 559
Query: 345 YMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLI----LTF 400
++APE ++ Q Y + DVWSLG+ L + G +PF + N P ++L + ++
Sbjct: 560 FVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPF---AMGPNDTPDQILQRVGDGKISM 616
Query: 401 TPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
T + D S K + L D R + +Q LQH W +GQ
Sbjct: 617 THPVWD------TISDEAKDLVRKMLDVDPNRRVTAKQALQHKW-IGQ 657
>YLR362w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 717
Score = 104 bits (259), Expect = 3e-22
Identities = 70/228 (30%), Positives = 117/228 (50%), Gaps = 26/228 (11%)
Query: 225 ELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLG 284
E+ K + IV YYG A +E + I +EY+ G S+ S +L+ G E ++
Sbjct: 504 EMNLLKELHHENIVTYYG--ASQEGGNLNIFLEYVPGGSVSS----MLNNYGPFEESLIT 557
Query: 285 KIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGE-----AVNSLATTF 339
+L G+ YLH++ IIHRDIK NIL + G +K+ DFG+S + + +
Sbjct: 558 NFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASL 617
Query: 340 TGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF-DTDKLAANMPPIELLMLIL 398
G+ ++M+PE ++ + +D+WS G ++E+ G PF D ++ A + +
Sbjct: 618 QGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQA------IFKIGT 671
Query: 399 TFTPELKDEPEQGIVWSKS-FKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
TPE+ W+ S K+FL + + D + RPS ++LQHPW+
Sbjct: 672 NTTPEIPS-------WATSEGKNFLRKAFELDYQYRPSALELLQHPWL 712
>HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 618
Score = 104 bits (259), Expect = 3e-22
Identities = 84/272 (30%), Positives = 126/272 (45%), Gaps = 32/272 (11%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIA----TIENDGSEKQIFRELQFNKSCKSDFIVR 239
+LG+G G V C + + A+K + + E + E+Q K+ + IV+
Sbjct: 360 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNFLHERIVQ 419
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
YYG + T+ I MEYM G S+ K L G + E K +L G+ YLH
Sbjct: 420 YYGCLRDPQEKTLSIFMEYMPGGSI----KDQLKAYGALTENGTRKYTRQILEGVHYLHS 475
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFG---------VSGEAVNSLATTFTGTSYYMAPER 350
I+HRDIK NIL + G +KL DFG +SG + S+ TGT Y+M+PE
Sbjct: 476 NMILHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSV----TGTPYWMSPEV 531
Query: 351 IQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQ 410
I GQ Y +D+WS+ T++E+ P+ A + + I T K P
Sbjct: 532 ISGQGYGRKADIWSVACTVVEMLTEKPPW------AEFEAMAAIFKIATQPTNPKLPPHV 585
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQH 442
S + FL + ++K RPS ++L+H
Sbjct: 586 ----SDYTRDFLK-RIFVEAKLRPSADELLRH 612
>CE17354 [T] KOG0694 Serine/threonine protein kinase
Length = 567
Score = 104 bits (259), Expect = 3e-22
Identities = 77/281 (27%), Positives = 137/281 (48%), Gaps = 23/281 (8%)
Query: 115 QQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGK---ESEIIEHDRDDSTDELESDIW- 170
++ T + S N+ +++ + T+ ++ SL N K +S + TDE +IW
Sbjct: 165 KRGTHATASCPPNIANLHLNGETSKNNGSLPNKLKNLFKSHQYSVEEQKETDEYMDNIWG 224
Query: 171 ------QTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTI---ATIENDGSEKQ 221
+ + + + L +LG+G+ G V +L+ ++ +A+K + +E+D +E
Sbjct: 225 GGDGPVKKFAL-PHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECT 283
Query: 222 IFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEK 281
+ + F+ + + F E +F MEY+ G L H + + + E
Sbjct: 284 YIERRVLILASQCPFLCQLFCSFQTNEY--LFFVMEYLNGGDL----MHHIQQIKKFDEA 337
Query: 282 VLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN---SLATT 338
A ++ L +LH II+RD+K N+L + G IKL DFG++ +N +A+T
Sbjct: 338 RTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMAST 397
Query: 339 FTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF 379
F GT Y++PE I+GQ Y+ D WS G+ + E+ G SPF
Sbjct: 398 FCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPF 438
>CE17353 [T] KOG0694 Serine/threonine protein kinase
Length = 704
Score = 104 bits (259), Expect = 3e-22
Identities = 77/281 (27%), Positives = 137/281 (48%), Gaps = 23/281 (8%)
Query: 115 QQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGK---ESEIIEHDRDDSTDELESDIW- 170
++ T + S N+ +++ + T+ ++ SL N K +S + TDE +IW
Sbjct: 302 KRGTHATASCPPNIANLHLNGETSKNNGSLPNKLKNLFKSHQYSVEEQKETDEYMDNIWG 361
Query: 171 ------QTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTI---ATIENDGSEKQ 221
+ + + + L +LG+G+ G V +L+ ++ +A+K + +E+D +E
Sbjct: 362 GGDGPVKKFAL-PHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECT 420
Query: 222 IFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEK 281
+ + F+ + + F E +F MEY+ G L H + + + E
Sbjct: 421 YIERRVLILASQCPFLCQLFCSFQTNEY--LFFVMEYLNGGDL----MHHIQQIKKFDEA 474
Query: 282 VLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN---SLATT 338
A ++ L +LH II+RD+K N+L + G IKL DFG++ +N +A+T
Sbjct: 475 RTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMAST 534
Query: 339 FTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF 379
F GT Y++PE I+GQ Y+ D WS G+ + E+ G SPF
Sbjct: 535 FCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPF 575
>At1g12680 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 470
Score = 104 bits (259), Expect = 3e-22
Identities = 83/277 (29%), Positives = 132/277 (46%), Gaps = 38/277 (13%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSD-FIVRYYGM 243
+G+G GSV CK R FA KT+ E+ + RE++ + +V + +
Sbjct: 113 IGKGKFGSVRICKSRKNGTEFACKTLKK-----GEETVHREVEIMQHLSGHPRVVTLHAV 167
Query: 244 FACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
+ EE+ + ME GGR +D + K GR E+ I + ++ + Y HE +
Sbjct: 168 Y--EESDCFHLVMELCSGGRLIDQMVKV-----GRYSEQRAANIFKDLMLVINYCHEMGV 220
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVS-----GEAVNSLATTFTGTSYYMAPERIQGQPYS 357
+HRDIKP+NIL G+I+L DFG++ G+ ++ LA G+ Y+APE + + YS
Sbjct: 221 VHRDIKPENILLTAAGKIQLADFGLAMRIAKGQTLSGLA----GSPAYVAPE-VLSENYS 275
Query: 358 VTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVW--- 414
DVWS G+ L + G PF D L A I+ + L VW
Sbjct: 276 EKVDVWSAGVLLYALLSGVLPFKGDSLDAIFEAIKNVKLDFNTG-----------VWESV 324
Query: 415 SKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKK 451
SK + L L ++ R + ++L+HPW++ T +
Sbjct: 325 SKPARDLLARMLTREESARITADEVLRHPWILFYTDR 361
>7303111 [T] KOG0695 Serine/threonine protein kinase
Length = 690
Score = 104 bits (259), Expect = 3e-22
Identities = 69/224 (30%), Positives = 118/224 (51%), Gaps = 14/224 (6%)
Query: 163 DELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEK 220
D LE + Y +++ + + ++G G+ V +LR +I+A+K I A + +D
Sbjct: 246 DPLEPGTQRQYSLND-FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDID 304
Query: 221 QIFRELQ-FNKSCKSDFIVRYYGMFACEET-STIFIAMEYMGGRSLDSVYKHLLSKGGRI 278
+ E F + F+V G+ +C +T S +F +E++ G L + + + R+
Sbjct: 305 WVQTEKHVFETASNHPFLV---GLHSCFQTPSRLFFVIEFVRGGDL----MYHMQRQRRL 357
Query: 279 GEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN--SLA 336
E+ A + L +LHE+ II+RD+K N+L + G IKL D+G+ E +
Sbjct: 358 PEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTT 417
Query: 337 TTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFD 380
+TF GT Y+APE ++G+ Y + D W+LG+ L E+ G SPFD
Sbjct: 418 STFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFD 461
>SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase
Length = 891
Score = 103 bits (258), Expect = 4e-22
Identities = 83/288 (28%), Positives = 130/288 (44%), Gaps = 42/288 (14%)
Query: 184 ILGEGTG-GSVTKCKLRNGSKI---FALKTIATIENDGSEKQIFRELQFNKSCKSDF--- 236
+LG+ G GS+ K K+ + K FA+K + + D ++ + + K+ +S+
Sbjct: 126 VLGKTIGAGSMGKVKVAHHLKTGEQFAIKIVTRLHPDITKAKAAASAEATKAAQSEKNKE 185
Query: 237 --IVRYYGM-------FACEE------TSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGE 280
VR + + CE S ++ E++ GG+ LD + H G++ E
Sbjct: 186 IRTVREAALSTLLRHPYICEARDVYITNSHYYMVFEFVDGGQMLDYIISH-----GKLKE 240
Query: 281 KVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSG-EAVNSLATTF 339
K K + L YLH+ ++HRD+K +NIL ++ G IK+ DFG+S S TF
Sbjct: 241 KQARKFVRQIGSALSYLHQNSVVHRDLKIENILISKTGDIKIIDFGLSNLYRRQSRLRTF 300
Query: 340 TGTSYYMAPERIQGQPY-SVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLIL 398
G+ Y+ APE + QPY DVWS G+ L + G PFD ++A I+
Sbjct: 301 CGSLYFAAPELLNAQPYIGPEVDVWSFGIVLYVLVCGKVPFDDQNMSALHAKIK------ 354
Query: 399 TFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
K E S K L L D R + ++L HPWM+
Sbjct: 355 ------KGTVEYPSYLSSDCKGLLSRMLVTDPLKRATLEEVLNHPWMI 396
>Hs20535816 [T] KOG0695 Serine/threonine protein kinase
Length = 592
Score = 103 bits (258), Expect = 4e-22
Identities = 75/267 (28%), Positives = 130/267 (48%), Gaps = 26/267 (9%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIAT--------IENDGSEKQIFRELQF 228
+ D + ++G G+ V +L+ +I+A+K + I+ +EK +F +
Sbjct: 250 QDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS 309
Query: 229 NKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAE 288
N F+V + F + TS +F+ +EY+ G L + + ++ E+ A
Sbjct: 310 NP-----FLVGLHSCF--QTTSRLFLVIEYVNGGDL----MFHMQRQRKLPEEHARFYAA 358
Query: 289 SVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN--SLATTFTGTSYYM 346
+ L +LHER II+RD+K N+L + G IKL D+G+ E + +TF GT Y+
Sbjct: 359 EICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYI 418
Query: 347 APERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKD 406
APE ++G+ Y + D W+LG+ + E+ G SPFD +M + L ++ P ++
Sbjct: 419 APEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKP-IRI 477
Query: 407 EPEQGIVWSKSFKSFLDYSLKKDSKDR 433
+ S K FL+ KD K+R
Sbjct: 478 PRFLSVKASHVLKGFLN----KDPKER 500
>Hs10864650 [T] KOG0695 Serine/threonine protein kinase
Length = 592
Score = 103 bits (258), Expect = 4e-22
Identities = 75/267 (28%), Positives = 130/267 (48%), Gaps = 26/267 (9%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIAT--------IENDGSEKQIFRELQF 228
+ D + ++G G+ V +L+ +I+A+K + I+ +EK +F +
Sbjct: 250 QDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS 309
Query: 229 NKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAE 288
N F+V + F + TS +F+ +EY+ G L + + ++ E+ A
Sbjct: 310 NP-----FLVGLHSCF--QTTSRLFLVIEYVNGGDL----MFHMQRQRKLPEEHARFYAA 358
Query: 289 SVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN--SLATTFTGTSYYM 346
+ L +LHER II+RD+K N+L + G IKL D+G+ E + +TF GT Y+
Sbjct: 359 EICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYI 418
Query: 347 APERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKD 406
APE ++G+ Y + D W+LG+ + E+ G SPFD +M + L ++ P ++
Sbjct: 419 APEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKP-IRI 477
Query: 407 EPEQGIVWSKSFKSFLDYSLKKDSKDR 433
+ S K FL+ KD K+R
Sbjct: 478 PRFLSVKASHVLKGFLN----KDPKER 500
>At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 594
Score = 103 bits (258), Expect = 4e-22
Identities = 81/272 (29%), Positives = 132/272 (47%), Gaps = 26/272 (9%)
Query: 185 LGEGTGGSVTKCKLRNGS---KIFALKTIATIENDG--SEKQIFRELQFNKSCKS-DFIV 238
+G G G K + G + A+K I+ + S + + RE++ K+ +V
Sbjct: 148 VGRGHFGHTCWAKAKKGKIKGQTVAVKIISKSKMTSALSIEDVRREVKLLKALSGHSHMV 207
Query: 239 RYYGMFACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYL 297
++Y +F E++ +F+ ME GG LDS+ L++GGR E +I +L +
Sbjct: 208 KFYDVF--EDSDNVFVVMELCEGGELLDSI----LARGGRYPEAEAKRILVQILSATAFF 261
Query: 298 HERKIIHRDIKPQNILF---NEIGQIKLCDFGVSGEA-VNSLATTFTGTSYYMAPERIQG 353
H + ++HRD+KP+N LF NE +K+ DFG+S A + G++YY+APE +
Sbjct: 262 HLQGVVHRDLKPENFLFTSKNEDAVLKVIDFGLSDYARFDQRLNDVVGSAYYVAPE-VLH 320
Query: 354 QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIV 413
+ YS +D+WS+G+ + G PF +A + +L P D P I
Sbjct: 321 RSYSTEADIWSIGVISYILLCGSRPFYGRTESA------IFRCVLRANPNFDDLPWPSI- 373
Query: 414 WSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
S K F+ L KD + R + Q L HPW+
Sbjct: 374 -SPIAKDFVKRLLNKDHRKRMTAAQALAHPWL 404
>YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 397
Score = 103 bits (257), Expect = 5e-22
Identities = 67/213 (31%), Positives = 109/213 (50%), Gaps = 21/213 (9%)
Query: 175 IHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIAT--------IENDGSEKQIFREL 226
+++ L LG G+ G V + R+ + +A+K + +E+ E+ + +
Sbjct: 83 VYKNFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIV 142
Query: 227 QFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKI 286
FI+R +G F ++ IF+ M+Y+ G L S LL K R V
Sbjct: 143 TH------PFIIRMWGTF--QDAQQIFMIMDYIEGGELFS----LLRKSQRFPNPVAKFY 190
Query: 287 AESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYM 346
A V L YLH + II+RD+KP+NIL ++ G IK+ DFG + + V + T GT Y+
Sbjct: 191 AAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFA-KYVPDVTYTLCGTPDYI 249
Query: 347 APERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF 379
APE + +PY+ + D WS G+ + E+ G++PF
Sbjct: 250 APEVVSTKPYNKSIDWWSFGILIYEMLAGYTPF 282
>SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 512
Score = 103 bits (257), Expect = 5e-22
Identities = 67/211 (31%), Positives = 104/211 (48%), Gaps = 20/211 (9%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIAT--------IENDGSEKQIFRELQF 228
+ + L LG G+ G V + + +A+K + IE+ E+ I +Q
Sbjct: 199 QDFNFLQTLGTGSFGRVHLVQSNHNRLYYAIKVLEKKKIVDMKQIEHTCDERYILSRVQH 258
Query: 229 NKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAE 288
FI +G F ++ +F+ M++ G L S LL K R EKV A
Sbjct: 259 ------PFITILWGTF--QDAKNLFMVMDFAEGGELFS----LLRKCHRFPEKVAKFYAA 306
Query: 289 SVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAP 348
V+ L YLH +I++RD+KP+N+L + G +K+ DFG + S T GT Y+AP
Sbjct: 307 EVILALDYLHHNQIVYRDLKPENLLLDRFGHLKIVDFGFAKRVSTSNCCTLCGTPDYLAP 366
Query: 349 ERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF 379
E I +PY+ +D WSLG+ + E+ G+ PF
Sbjct: 367 EIISLKPYNKAADWWSLGILIFEMLAGYPPF 397
>Hs14916455 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 385
Score = 103 bits (256), Expect = 7e-22
Identities = 79/279 (28%), Positives = 132/279 (46%), Gaps = 21/279 (7%)
Query: 174 KIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCK 233
++ + D ++G G+ V + + + K FA+K + T E +G E + EL +
Sbjct: 58 RVLARYDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACV-SELSVLRRVS 116
Query: 234 SDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRG 293
+IV+ +F E+ +++ ME G L + L+++G E+ +I + V G
Sbjct: 117 HRYIVQLMEIFETEDQ--VYMVMELATGGEL---FDRLIAQGS-FTERDAVRILQMVADG 170
Query: 294 LFYLHERKIIHRDIKPQNILFNEIGQ---IKLCDFGVSGEAVNS---LATTFTGTSYYMA 347
+ YLH +I HR++KP+N+L+ G+ I + DFG++ S T GT Y+A
Sbjct: 171 IRYLHALQITHRNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIA 230
Query: 348 PERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDE 407
PE + +PY+ D+W+LG+ + G PFD + L IL E
Sbjct: 231 PEVLLRKPYTSAVDMWALGVITYALLSGFLPFDDES------QTRLYRKILKGKYNYTGE 284
Query: 408 PEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
P I S K F+D L ++ R S Q L HPW++
Sbjct: 285 PWPSI--SHLAKDFIDKLLILEAGHRMSAGQALDHPWVI 321
>At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 594
Score = 103 bits (256), Expect = 7e-22
Identities = 79/278 (28%), Positives = 138/278 (49%), Gaps = 34/278 (12%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSC 232
Y++ E++ GEG +V + + ++I A+K + + + I +E+
Sbjct: 16 YELFEEV------GEGVSATVYRARCIALNEIVAVKILDLEKCRNDLETIRKEVHIMSLI 69
Query: 233 KSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
+++ + F ++S+++I M YM G S + K + +G + + ++ + VL+
Sbjct: 70 DHPNLLKAHCSFI--DSSSLWIVMPYMSGGSCFHLMKSVYPEG--LEQPIIATLLREVLK 125
Query: 293 GLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGV------SGEAVNSLATTFTGTSYYM 346
L YLH + IHRD+K NIL + G +KL DFGV SGE + + TF GT +M
Sbjct: 126 ALVYLHRQGHIHRDVKAGNILIHSKGVVKLGDFGVSACMFDSGERMQT-RNTFVGTPCWM 184
Query: 347 APERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKD 406
APE +Q G +A GH+PF + PP+++L++ L P D
Sbjct: 185 APEVMQQLD----------GYDFKYLAHGHAPF------SKYPPMKVLLMTLQNAPPRLD 228
Query: 407 EPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPW 444
++ +SKSF+ + L KD K RP+ ++L+HP+
Sbjct: 229 Y-DRDKKFSKSFRELIAACLVKDPKKRPTAAKLLKHPF 265
>Hs4758702 [T] KOG4279 Serine/threonine protein kinase
Length = 1011
Score = 102 bits (255), Expect = 9e-22
Identities = 70/201 (34%), Positives = 105/201 (51%), Gaps = 9/201 (4%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGM 243
+LG+GT G V + R+ A+K I ++ S+ + E+ ++ + IVRY G
Sbjct: 376 VLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQP-LHEEIALHRRLRHKNIVRYLG- 433
Query: 244 FACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKII 303
+ + + I ME + G SL S+ + + + E + +L+GL YLH+ I+
Sbjct: 434 -SASQGGYLKIFMEEVPGGSLSSLLRSVWGPL-KDNESTISFYTRQILQGLGYLHDNHIV 491
Query: 304 HRDIKPQNILFNEI-GQIKLCDFGVSGE--AVNSLATTFTGTSYYMAPERIQGQP--YSV 358
HRDIK N+L N G +K+ DFG S + TFTGT YMAPE I P Y
Sbjct: 492 HRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGK 551
Query: 359 TSDVWSLGLTLLEVAQGHSPF 379
+D+WSLG T++E+A G PF
Sbjct: 552 AADIWSLGCTVIEMATGRPPF 572
>Hs4506071 [T] KOG0695 Serine/threonine protein kinase
Length = 587
Score = 102 bits (255), Expect = 9e-22
Identities = 66/215 (30%), Positives = 112/215 (51%), Gaps = 23/215 (10%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIAT-IENDG-------SEKQIFRELQF 228
+ D L ++G G+ V +L+ +I+A+K + + ND +EK +F +
Sbjct: 243 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQ--- 299
Query: 229 NKSCKSDFIVRYYGMFACEET-STIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIA 287
+ F+V G+ +C +T S +F +EY+ G L + + ++ E+ +
Sbjct: 300 --ASNHPFLV---GLHSCFQTESRLFFVIEYVNGGDL----MFHMQRQRKLPEEHARFYS 350
Query: 288 ESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN--SLATTFTGTSYY 345
+ L YLHER II+RD+K N+L + G IKL D+G+ E + +TF GT Y
Sbjct: 351 AEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNY 410
Query: 346 MAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFD 380
+APE ++G+ Y + D W+LG+ + E+ G SPFD
Sbjct: 411 IAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFD 445
>CE03232 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 294
Score = 102 bits (255), Expect = 9e-22
Identities = 64/204 (31%), Positives = 99/204 (48%), Gaps = 6/204 (2%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIE--NDGSEKQIFRELQFNKSCKSDFIVRYYG 242
+G+G V + + ALK I E + + + +E+ K ++RYY
Sbjct: 29 IGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYA 88
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F + + + I +E + + KH G I EK + K + R L ++H ++I
Sbjct: 89 SFI--DNNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEKTIWKYFVQLARALAHMHSKRI 146
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFTGTSYYMAPERIQGQPYSVTS 360
+HRDIKP N+ G +KL D G+ + + A + GT YYM+PERIQ Y+ S
Sbjct: 147 MHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKS 206
Query: 361 DVWSLGLTLLEVAQGHSPFDTDKL 384
D+WS G L E+A SPF DK+
Sbjct: 207 DLWSTGCLLYEMAALQSPFYGDKM 230
>YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1331
Score = 102 bits (254), Expect = 1e-21
Identities = 93/290 (32%), Positives = 138/290 (47%), Gaps = 46/290 (15%)
Query: 185 LGEGTGGSV-TKCKLRNGSKIFALKTIATIENDGSEKQIF----RELQFNKSCKSDFIVR 239
+G GT G V + L NG +I A+K I I + + K+IF E+ + IV+
Sbjct: 1040 IGGGTFGQVYSAINLENG-EILAVKEIK-IHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQ 1097
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAE-SVLRGLFYLH 298
YYG+ + IF MEY G SL S+ H GRI ++++ ++ +L GL YLH
Sbjct: 1098 YYGVEVHRDKVNIF--MEYCEGGSLASLLDH-----GRIEDEMVTQVYTFELLEGLAYLH 1150
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATT------------------FT 340
+ ++HRDIKP+NIL + G IK DFG + V S T
Sbjct: 1151 QSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMM 1210
Query: 341 GTSYYMAPERIQGQPYS---VTSDVWSLGLTLLEVAQGHSPF-DTDKLAANMPPIELLML 396
GT YMAPE I G DVW+LG +LE+A G P+ + D A M + +
Sbjct: 1211 GTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRI 1270
Query: 397 ILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
P+L + E + + ++FL+ L +D R + ++L PWM+
Sbjct: 1271 -----PQLPNRDEM----TAAGRAFLERCLVQDPTMRATAVELLIDPWMI 1311
>Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 1030
Score = 102 bits (254), Expect = 1e-21
Identities = 63/209 (30%), Positives = 110/209 (52%), Gaps = 10/209 (4%)
Query: 175 IHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIA-TIENDGSEKQIFRELQFNKSCK 233
+ + + LG++GEG G V KC+ + +I A+K + EN+ ++ REL+ ++ K
Sbjct: 9 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLK 68
Query: 234 SDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRG 293
+ IV F +++ EY+ L+ + + G EKV I + +++
Sbjct: 69 QENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEE---MPNGVPPEKVKSYIYQ-LIKA 122
Query: 294 LFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVS---GEAVNSLATTFTGTSYYMAPER 350
+ + H+ I+HRDIKP+N+L + +KLCDFG + E N+ T + T +Y +PE
Sbjct: 123 IHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPEL 182
Query: 351 IQGQPYSVTSDVWSLGLTLLEVAQGHSPF 379
+ G PY + D+WS+G L E++ G F
Sbjct: 183 LLGAPYGKSVDMWSVGCILGELSDGQPLF 211
>Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 620
Score = 102 bits (254), Expect = 1e-21
Identities = 83/272 (30%), Positives = 126/272 (45%), Gaps = 32/272 (11%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIA----TIENDGSEKQIFRELQFNKSCKSDFIVR 239
+LG+G G V C + + A+K + + E + E+Q K+ + IV+
Sbjct: 362 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLHERIVQ 421
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
YYG + T+ I MEYM G S+ K L G + E V K +L G+ YLH
Sbjct: 422 YYGCLRDPQEKTLSIFMEYMPGGSI----KDQLKAYGALTENVTRKYTRQILEGVHYLHS 477
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFG---------VSGEAVNSLATTFTGTSYYMAPER 350
I+ RDIK NIL + G +KL DFG +SG + S+ TGT Y+M+PE
Sbjct: 478 NMIVLRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSV----TGTPYWMSPEV 533
Query: 351 IQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQ 410
I G+ Y +D+WS+ T++E+ P+ A + + I T K P
Sbjct: 534 ISGEGYGRKADIWSVACTVVEMLTEKPPW------AEFEAMAAIFKIATQPTNPKLPPHV 587
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQH 442
S + FL + ++K RPS ++L+H
Sbjct: 588 ----SDYTRDFLK-RIFVEAKLRPSADELLRH 614
>Hs20547878 [R] KOG0589 Serine/threonine protein kinase
Length = 758
Score = 102 bits (253), Expect = 2e-21
Identities = 84/293 (28%), Positives = 135/293 (45%), Gaps = 46/293 (15%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF 236
++ D + +G+G G K ++ SK +K E+ F K F
Sbjct: 2 DKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIK----------------EINFEKHQMIPF 45
Query: 237 IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRI--GEKVLGKIAESVLRGL 294
+ E +FI MEY G L K + + G + +++LG + L GL
Sbjct: 46 LT---------ENGRLFIVMEYCDGGDL---MKRINRQRGVLFSEDQILGWFVQISL-GL 92
Query: 295 FYLHERKIIHRDIKPQNILFNEIGQI-KLCDFGVSGEAVNS--LATTFTGTSYYMAPERI 351
++H+RKI+HRDIK QNI ++ G + KL DFG++ NS LA T GT YY++PE
Sbjct: 93 KHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEIC 152
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQG 411
Q +PY+ +D+WSLG L E+ PF+ + N+ + L + F P
Sbjct: 153 QNKPYNNKTDIWSLGCVLYELCTLKHPFEGN----NLQQLVLKICQAHFAPISPG----- 203
Query: 412 IVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQTKKHVNMK-KFIQTCW 463
+S+ S + + +DRPS +L+ P++ K++ + F T W
Sbjct: 204 --FSRELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVSFEVTVW 254
>7302860 [T] KOG0696 Serine/threonine protein kinase
Length = 679
Score = 102 bits (253), Expect = 2e-21
Identities = 62/202 (30%), Positives = 103/202 (50%), Gaps = 11/202 (5%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTI---ATIENDGSEKQIFRELQFNKSCKSDFIVRY 240
+LG+G+ G V + + +++A+K + I++D E + + K F+V+
Sbjct: 355 VLGKGSFGKVLLAERKGSEELYAIKILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQL 414
Query: 241 YGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
+ F + +F MEY+ G L + + G+ E V A + GLF+LH +
Sbjct: 415 HSCF--QTMDRLFFVMEYVNGGDL----MFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTK 468
Query: 301 KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAV--NSLATTFTGTSYYMAPERIQGQPYSV 358
I++RD+K N+L + G +K+ DFG+ E + + TF GT Y+APE I QPY
Sbjct: 469 GILYRDLKLDNVLLDADGHVKIADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGK 528
Query: 359 TSDVWSLGLTLLEVAQGHSPFD 380
+ D W+ G+ L E+ G PFD
Sbjct: 529 SVDWWAYGVLLYEMLVGQPPFD 550
>7302464 [R] KOG0586 Serine/threonine protein kinase
Length = 739
Score = 102 bits (253), Expect = 2e-21
Identities = 86/285 (30%), Positives = 131/285 (45%), Gaps = 22/285 (7%)
Query: 104 INTDHLPTSGSQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTD 163
IN H T GS A ++ N++S + + P+ + G + +
Sbjct: 87 INHHHHHTPGSGV----APTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWR 142
Query: 164 ELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIE-NDGSEKQI 222
E I + YK+ + I G+G V K K A+K I + N GS +++
Sbjct: 143 ATEEHIGK-YKLIKTI------GKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKL 195
Query: 223 FRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEK 281
FRE++ K IV+ + + E+T +++ MEY GG D + H GR+ EK
Sbjct: 196 FREVRIMKMLDHPNIVKLFQVIETEKT--LYLIMEYASGGEVFDYLVLH-----GRMKEK 248
Query: 282 VLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGE-AVNSLATTFT 340
++ + Y H+++IIHRD+K +N+L + IK+ DFG S E S TF
Sbjct: 249 EARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFC 308
Query: 341 GTSYYMAPERIQGQPYSVTS-DVWSLGLTLLEVAQGHSPFDTDKL 384
G+ Y APE QG+ Y DVWSLG+ L + G PFD L
Sbjct: 309 GSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTL 353
>YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 842
Score = 101 bits (251), Expect = 3e-21
Identities = 66/197 (33%), Positives = 101/197 (50%), Gaps = 16/197 (8%)
Query: 252 IFIAMEYMGGRSLDSVYKHLLSKGGR---IGEKVLGKIAESVLRGLFYLHERKIIHRDIK 308
+++ ME+M G SL + ++ + + E + I +GL +LH++ IIHRDIK
Sbjct: 636 LWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIK 695
Query: 309 PQNILFNEIGQIKLCDFGVSGEAVN--SLATTFTGTSYYMAPERIQGQPYSVTSDVWSLG 366
N+L + ++K+ DFG + S T GT Y+MAPE ++ + Y DVWSLG
Sbjct: 696 SDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLG 755
Query: 367 LTLLEVAQGHSPFDTDKLAANMPPIELLMLILT-FTPELKDEPEQGIVWSKSFKSFLDYS 425
+ +E+ +G P+ N P++ L LI T TP+LK PE S K FL
Sbjct: 756 IMTIEMLEGEPPY------LNEDPLKALYLIATNGTPKLK-HPES---LSLEIKRFLSVC 805
Query: 426 LKKDSKDRPSPRQMLQH 442
L D + R S ++L H
Sbjct: 806 LCVDVRYRASTEELLHH 822
>SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 696
Score = 101 bits (251), Expect = 3e-21
Identities = 80/245 (32%), Positives = 126/245 (50%), Gaps = 39/245 (15%)
Query: 160 DSTDELESDIWQTYKIHEQID----------TLGILGEGTGGSVTKCKLRNGSKIFALKT 209
D T LE +I + I+E I+ L ++G+GT G V + + ++I+A+K
Sbjct: 274 DLTKSLEGEI-KVETIYEHIEHVRYGPEDFTALRLIGKGTFGQVYLVRKNDTNRIYAMKK 332
Query: 210 IATIENDGSEKQIFRELQFNKSC------------KSDFIVRYYGMFACEETSTIFIAME 257
I S+K I R+ + + +S FIV F+ + S +++ +
Sbjct: 333 I-------SKKLIVRKKEVTHTLGERNILVRTSLDESPFIVGL--KFSFQTASDLYLITD 383
Query: 258 YMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEI 317
YM G L + HL +G ++ IAE VL L +LH+ II+RD+KP+NIL +
Sbjct: 384 YMSGGEL---FWHLQHEGRFPEQRAKFYIAELVL-ALEHLHKHDIIYRDLKPENILLDAD 439
Query: 318 GQIKLCDFGVS--GEAVNSLATTFTGTSYYMAPE-RIQGQPYSVTSDVWSLGLTLLEVAQ 374
G I LCDFG+S + N+ TF GT+ Y+APE ++ + Y+ D WSLG+ + E+
Sbjct: 440 GHIALCDFGLSKANLSANATTNTFCGTTEYLAPEVLLEDKGYTKQVDFWSLGVLVFEMCC 499
Query: 375 GHSPF 379
G SPF
Sbjct: 500 GWSPF 504
>At1g05100 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 339
Score = 101 bits (251), Expect = 3e-21
Identities = 78/276 (28%), Positives = 128/276 (46%), Gaps = 30/276 (10%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMF 244
LG G+ +V+ + A+K+ ++ + RE + S S +++ Y G
Sbjct: 9 LGRGSTATVSAATCHESGETLAVKSAEFHRSEFLQ----REAKILSSLNSPYVIGYRG-- 62
Query: 245 ACE----------ETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGL 294
CE E +T + MEY +L V GG I E + K +L GL
Sbjct: 63 -CEITREPFHNNGEATTYSLLMEYAPYGTLTDV---ATKNGGFIDEARVVKYTRQILLGL 118
Query: 295 FYLHERK-IIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQG 353
Y+H K I H DIK N+L E G+ K+ DFG + + GT +MAPE +G
Sbjct: 119 EYIHNSKGIAHCDIKGSNVLVGENGEAKIADFGCAKWVEPEITEPVRGTPAFMAPEAARG 178
Query: 354 QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANM-PPIELLMLILTFTPELKDEPEQGI 412
+ SD+W++G T++E+ G P+ + A+ P+ +L + L + PE
Sbjct: 179 ERQGKESDIWAVGCTVIEMVTGSQPW----IGADFTDPVSVLYRV----GYLGELPELPC 230
Query: 413 VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
++ K FL LKK++ +R + Q+L HP++V +
Sbjct: 231 SLTEQAKDFLGKCLKKEATERWTASQLLNHPFLVNK 266
>Hs4826948 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 358
Score = 100 bits (250), Expect = 4e-21
Identities = 65/208 (31%), Positives = 102/208 (48%), Gaps = 9/208 (4%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALK--TIATIENDGSEKQIFRELQFNKSCKS 234
+ DTL +G GT G V K + FALK +I + E+ + E K
Sbjct: 47 QDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSH 106
Query: 235 DFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGL 294
F++R + + + +++ MEY+ G L S L GR + ++ +
Sbjct: 107 PFLIRLF--WTWHDERFLYMLMEYVPGGELFSY----LRNRGRFSSTTGLFYSAEIICAI 160
Query: 295 FYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQ 354
YLH ++I++RD+KP+NIL + G IKL DFG + + V+ T GT Y+APE IQ +
Sbjct: 161 EYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDR-TWTLCGTPEYLAPEVIQSK 219
Query: 355 PYSVTSDVWSLGLTLLEVAQGHSPFDTD 382
+ D W+LG+ + E+ G PF D
Sbjct: 220 GHGRAVDWWALGILIFEMLSGFPPFFDD 247
>CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 1101
Score = 100 bits (250), Expect = 4e-21
Identities = 82/281 (29%), Positives = 138/281 (48%), Gaps = 20/281 (7%)
Query: 112 SGSQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQ 171
S + S+ A S T+ + S P T S+ V GK + ++ + T L + I
Sbjct: 705 SDEKGSSLDAQSWTTAIQSAL--MPVTPQSS--VVGGKRIDKLKVPTEGETGHLGAKIQT 760
Query: 172 TYKIHE--QIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFR-ELQF 228
++ + QI +LG G G+V R + A+K I ++ +++ + R E+Q
Sbjct: 761 EHEFSQLYQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDLLRAEVQI 820
Query: 229 NKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAE 288
+ +V + M E T IF+ ME + G L+ + L S+ GR+ E+ +
Sbjct: 821 LEKVDHPGVVHFMQML--ETTDRIFVVMEKLKGDMLEMI---LSSEKGRLSERTTQFLVA 875
Query: 289 SVLRGLFYLHERKIIHRDIKPQNILFN---EIGQIKLCDFG---VSGEAVNSLATTFTGT 342
+L L YLH I+H D+KP+NIL N + Q+KLCDFG + GE S + GT
Sbjct: 876 QILEALRYLHHLNIVHCDLKPENILLNSNSDFPQVKLCDFGFARIIGE--KSFRRSVVGT 933
Query: 343 SYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDK 383
Y+APE ++ + ++ + D+WS+G+ + G PF+ D+
Sbjct: 934 PAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSGTFPFNEDE 974
>CE15475 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 375
Score = 100 bits (250), Expect = 4e-21
Identities = 76/283 (26%), Positives = 133/283 (46%), Gaps = 36/283 (12%)
Query: 140 SSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLR 199
SS N E ++ R+D E+ T + + D + LG G+ G V K +
Sbjct: 14 SSKDNKNSASLKEFLDKAREDFKQRWENPAQNTACL-DDFDRIKTLGTGSFGRVMLVKHK 72
Query: 200 NGSKIFALKTI--------ATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETST 251
+A+K + +E+ +EK+I + + F F+V F+ ++ S
Sbjct: 73 QSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDF------PFLVNM--TFSFKDNSN 124
Query: 252 IFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQN 311
+++ +E++ G + S + + GR E A ++ YLH +I+RD+KP+N
Sbjct: 125 LYMVLEFISGGEMFSHLRRI----GRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPEN 180
Query: 312 ILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLE 371
+L + G +K+ DFG + + V T GT Y+APE I + Y+ D W+LG+ + E
Sbjct: 181 LLIDSTGYLKITDFGFA-KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYE 239
Query: 372 VAQGHSPFDTDKLAANMPPIELLMLILT--------FTPELKD 406
+A G+ PF D+ PI++ I++ F+ ELKD
Sbjct: 240 MAAGYPPFFADQ------PIQIYEKIVSGKVKFPSHFSNELKD 276
>CE15473 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 359
Score = 100 bits (250), Expect = 4e-21
Identities = 76/283 (26%), Positives = 133/283 (46%), Gaps = 36/283 (12%)
Query: 140 SSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLR 199
SS N E ++ R+D E+ T + + D + LG G+ G V K +
Sbjct: 14 SSKDNKNSASLKEFLDKAREDFKQRWENPAQNTACL-DDFDRIKTLGTGSFGRVMLVKHK 72
Query: 200 NGSKIFALKTI--------ATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETST 251
+A+K + +E+ +EK+I + + F F+V F+ ++ S
Sbjct: 73 QSGNYYAMKILDKQKVVKLKQVEHTLNEKRILQAIDF------PFLVNM--TFSFKDNSN 124
Query: 252 IFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQN 311
+++ +E++ G + S + + GR E A ++ YLH +I+RD+KP+N
Sbjct: 125 LYMVLEFISGGEMFSHLRRI----GRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPEN 180
Query: 312 ILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLE 371
+L + G +K+ DFG + + V T GT Y+APE I + Y+ D W+LG+ + E
Sbjct: 181 LLIDSTGYLKITDFGFA-KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYE 239
Query: 372 VAQGHSPFDTDKLAANMPPIELLMLILT--------FTPELKD 406
+A G+ PF D+ PI++ I++ F+ ELKD
Sbjct: 240 MAAGYPPFFADQ------PIQIYEKIVSGKVKFPSHFSNELKD 276
>CE02586 [T] KOG0696 Serine/threonine protein kinase
Length = 861
Score = 100 bits (250), Expect = 4e-21
Identities = 65/204 (31%), Positives = 104/204 (50%), Gaps = 11/204 (5%)
Query: 182 LGILGEGTGGSVTKCKLRNGSKIFALKTI---ATIENDGSEKQIFRELQFNKSCKSDFIV 238
L +LG+G+ G V + + ++FA+K + I++D E + + K F+V
Sbjct: 416 LTVLGKGSFGKVLLGEQKTTKELFAIKVLKKDVIIQDDDVECTMTEKRVLALPEKPSFLV 475
Query: 239 RYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
+ F + ++ ME++ G L + + + G+ E V A + GLF+LH
Sbjct: 476 ALHSCF--QTMDRLYFVMEFVNGGDL----MYQIQQVGKFKEPVAVFYAAEIAVGLFFLH 529
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLAT--TFTGTSYYMAPERIQGQPY 356
+ II+RD+K N++ G IK+ DFG+ E + AT TF GT Y+APE I QPY
Sbjct: 530 SKGIIYRDLKLDNVMLERDGHIKITDFGMCKENIFGDATTKTFCGTPDYIAPEIILYQPY 589
Query: 357 SVTSDVWSLGLTLLEVAQGHSPFD 380
+ D W+ G+ L E+ G PFD
Sbjct: 590 GKSVDWWAYGVLLFEMLAGQPPFD 613
>SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1116
Score = 100 bits (249), Expect = 5e-21
Identities = 83/280 (29%), Positives = 128/280 (45%), Gaps = 33/280 (11%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIE-----NDGSEKQIFRELQFNKSCKSDF-- 236
++G GT G V N ++ A+K + + +D K I + S +D
Sbjct: 830 LIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAEISMIADLDH 889
Query: 237 --IVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGL 294
IV+Y G E +IF+ EY+ G S+ ++ G E+++ ++ VL GL
Sbjct: 890 LNIVQYLGFEKTETDISIFL--EYVSGGSIGRCLRNY----GPFEEQLVRFVSRQVLYGL 943
Query: 295 FYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEA----VNSLATTFTGTSYYMAPER 350
YLH + IIHRD+K N+L + G K+ DFG+S + N + G+ ++MAPE
Sbjct: 944 SYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQGSIFWMAPEV 1003
Query: 351 IQG--QPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEP 408
I Q YS DVWSLG +LE+ G P+ TD E + + E K P
Sbjct: 1004 IHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTD---------EAIQAMFKLGTEKKAPP 1054
Query: 409 ---EQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
E S FL+ ++ RP+ ++L HP+M
Sbjct: 1055 IPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHPFM 1094
>At4g08480 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 773
Score = 100 bits (249), Expect = 5e-21
Identities = 76/270 (28%), Positives = 137/270 (50%), Gaps = 28/270 (10%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF----IVR 239
+L +G+ GSV + +G FA+K ++ ++ ++ ++L+ + S I+R
Sbjct: 506 LLRQGSFGSVYEAISEDGD-FFAVKEVSLLDQGSQAQECIQQLEGEIALLSQLEHQNILR 564
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
Y G ++ S ++I +E + SL +Y+ +I + ++ + +L GL YLH
Sbjct: 565 YRG--TDKDGSNLYIFLELVTQGSLLELYRRY-----QIRDSLISLYTKQILDGLKYLHH 617
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPE---RIQGQPY 356
+ IHRDIK IL + G +KL DFG++ + + + T ++MAPE R Y
Sbjct: 618 KGFIHRDIKCATILVDANGTVKLADFGLAKVSKLNDIKSRKETLFWMAPEVINRKDNDGY 677
Query: 357 SVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFT-PELKDEPEQGIVWS 415
+D+WSLG T+LE+ G P+ +++ P+E L I T PE+ D S
Sbjct: 678 RSPADIWSLGCTVLEMCTGQIPY------SDLEPVEALFRIRRGTLPEVPD------TLS 725
Query: 416 KSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+ F+ LK + ++RP+ ++L HP++
Sbjct: 726 LDARHFILKCLKLNPEERPTATELLNHPFV 755
>At4g08470 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 560
Score = 100 bits (249), Expect = 5e-21
Identities = 74/270 (27%), Positives = 136/270 (49%), Gaps = 26/270 (9%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDF----IVR 239
+LG G+ SV + +G FA+K ++ ++ ++ ++L+ + S IVR
Sbjct: 308 LLGRGSYASVYEAISEDGD-FFAVKEVSLLDKGIQAQECIQQLEGEIALLSQLQHQNIVR 366
Query: 240 YYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHE 299
Y G ++ S ++I +E + S+ +Y+ ++ V+ +L GL YLH+
Sbjct: 367 YRG--TAKDVSKLYIFLELVTQGSVQKLYERY-----QLSYTVVSLYTRQILAGLNYLHD 419
Query: 300 RKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPE---RIQGQPY 356
+ +HRDIK N+L + G +KL DFG++ + + + GT ++MAPE R
Sbjct: 420 KGFVHRDIKCANMLVDANGTVKLADFGLAEASKFNDIMSCKGTLFWMAPEVINRKDSDGN 479
Query: 357 SVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSK 416
+D+WSLG T+LE+ G P+ +++ PI+ I T L D P+ S
Sbjct: 480 GSPADIWSLGCTVLEMCTGQIPY------SDLKPIQAAFKIGRGT--LPDVPD---TLSL 528
Query: 417 SFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
+ F+ LK + ++RP+ ++L HP+++
Sbjct: 529 DARHFILTCLKVNPEERPTAAELLHHPFVI 558
>At2g46700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 595
Score = 100 bits (249), Expect = 5e-21
Identities = 74/248 (29%), Positives = 121/248 (47%), Gaps = 33/248 (13%)
Query: 207 LKTIATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYM-GGRSLD 265
+ T IE+ E ++ + L +K ++++YY ACE+ + ++I ME GG LD
Sbjct: 182 MTTAIAIEDVRREVKLLKSLSGHK-----YLIKYYD--ACEDANNVYIVMELCDGGELLD 234
Query: 266 SVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILF---NEIGQIKL 322
+ L++GG+ E I +L + + H + ++HRD+KP+N LF E +KL
Sbjct: 235 RI----LARGGKYPEDDAKAIVVQILTVVSFCHLQGVVHRDLKPENFLFTSSREDSDLKL 290
Query: 323 CDFGVS-----GEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHS 377
DFG+S E +N + G++YY+APE + + YS+ +D+WS+G+ + G
Sbjct: 291 IDFGLSDFIRPDERLNDI----VGSAYYVAPE-VLHRSYSLEADIWSIGVITYILLCGSR 345
Query: 378 PFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPR 437
PF + + +L P D P S K F+ L KD + R S
Sbjct: 346 PFWARTESG------IFRTVLRTEPNYDDVPWPSC--SSEGKDFVKRLLNKDYRKRMSAV 397
Query: 438 QMLQHPWM 445
Q L HPW+
Sbjct: 398 QALTHPWL 405
>YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 305
Score = 99.8 bits (247), Expect = 8e-21
Identities = 88/300 (29%), Positives = 135/300 (44%), Gaps = 42/300 (14%)
Query: 178 QIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSDFI 237
Q L LG GT +V K + ALK + +G+ RE+ K K + I
Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENI 65
Query: 238 VRYYGMFACEETSTIFIAM------EYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAE-SV 290
VR Y + E T+ +YM R++ + + L E L K + +
Sbjct: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGL--------ELNLVKYFQWQL 117
Query: 291 LRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVS---GEAVNSLATTFTGTSYYMA 347
L+GL + HE KI+HRD+KPQN+L N+ GQ+KL DFG++ G VN+ ++ T +Y A
Sbjct: 118 LQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TLWYRA 176
Query: 348 PERIQG-QPYSVTSDVWSLGLTLLEVAQGHSPF----DTDKLAANM----PPIELLMLIL 398
P+ + G + YS + D+WS G L E+ G F D ++L P E L +
Sbjct: 177 PDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSV 236
Query: 399 T----FTPELKDEPEQGI----------VWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPW 444
T + P ++ P + + + FL L+ + R S +Q L HPW
Sbjct: 237 TKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPW 296
>Hs13899225 [R] KOG0586 Serine/threonine protein kinase
Length = 688
Score = 99.8 bits (247), Expect = 8e-21
Identities = 66/206 (32%), Positives = 105/206 (50%), Gaps = 9/206 (4%)
Query: 182 LGILGEGTGGSVTKCKLRNGSKIFALKTIATIE-NDGSEKQIFRELQFNKSCKSDFIVRY 240
L +G+G V + + A+K I + N S +++FRE++ K IV+
Sbjct: 62 LRTIGKGNSAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKL 121
Query: 241 YGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
+ + E+T +++ MEY S V+ +L+S G R+ EK ++ + Y H++
Sbjct: 122 FEVIETEKT--LYLVMEYA---SAGEVFDYLVSHG-RMKEKEARAKFRQIVSAVHYCHQK 175
Query: 301 KIIHRDIKPQNILFNEIGQIKLCDFGVSGE-AVNSLATTFTGTSYYMAPERIQGQPYSVT 359
I+HRD+K +N+L + IK+ DFG S E + S TF G+ Y APE QG+ Y
Sbjct: 176 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 235
Query: 360 S-DVWSLGLTLLEVAQGHSPFDTDKL 384
D+WSLG+ L + G PFD L
Sbjct: 236 EVDIWSLGVILYTLVSGSLPFDGHNL 261
>Hs10835065 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 277
Score = 99.8 bits (247), Expect = 8e-21
Identities = 66/208 (31%), Positives = 105/208 (49%), Gaps = 9/208 (4%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALK--TIATIENDGSEKQIFRELQFNKSCKS 234
+ D L +G GT G V K + FALK +I + E+ + E K
Sbjct: 47 QDCDALVTMGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRRKQEQHVHNEKSVLKEVSH 106
Query: 235 DFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGL 294
F++R + + E +++ MEY+ G L + +L ++G L AE ++ +
Sbjct: 107 PFLIRLF--WTWHEERFLYMLMEYVPGGEL---FSYLRNRGHFSSTTGLFYSAE-IICAI 160
Query: 295 FYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTGTSYYMAPERIQGQ 354
YLH ++I++RD+KP+NIL + G IKL DFG + + V+ T GT Y+APE IQ +
Sbjct: 161 EYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDR-TWTLCGTPEYLAPEVIQSK 219
Query: 355 PYSVTSDVWSLGLTLLEVAQGHSPFDTD 382
+ D W+LG+ + E+ G PF D
Sbjct: 220 GHGRAVDWWALGILIFEMLSGFPPFFDD 247
>Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 685
Score = 99.4 bits (246), Expect = 1e-20
Identities = 69/267 (25%), Positives = 126/267 (46%), Gaps = 22/267 (8%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSDFIVRYY 241
+LG+G + +K++A K I + + ++I +E++ ++ +V++Y
Sbjct: 87 VLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFY 146
Query: 242 GMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERK 301
F E+ I+I +EY RS+ H+L + E + ++ GL YLHE++
Sbjct: 147 HYF--EDKENIYILLEYCSRRSM----AHILKARKVLTEPEVRYYLRQIVSGLKYLHEQE 200
Query: 302 IIHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFTGTSYYMAPERIQGQPYSVT 359
I+HRD+K N NE ++K+ DFG++ E + T GT Y++PE + Q +
Sbjct: 201 ILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCE 260
Query: 360 SDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFK 419
SD+W+LG + + G PF+T L I + P P + ++ S
Sbjct: 261 SDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTM---PSSLLAPAKHLIAS---- 313
Query: 420 SFLDYSLKKDSKDRPSPRQMLQHPWMV 446
L K+ +DRPS +++H + +
Sbjct: 314 -----MLSKNPEDRPSLDDIIRHDFFL 335
>Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 445
Score = 99.4 bits (246), Expect = 1e-20
Identities = 65/211 (30%), Positives = 100/211 (46%), Gaps = 8/211 (3%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIF-RELQFNKSCKSD 235
E + L +G G+ G K + ++ KI K + +EKQ+ E+ + K
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
IVRYY +T++I MEY G L SV + + E+ + ++ + L
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 296 YLHERK-----IIHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFTGTSYYMAP 348
H R ++HRD+KP N+ + +KL DFG++ S A TF GT YYM+P
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185
Query: 349 ERIQGQPYSVTSDVWSLGLTLLEVAQGHSPF 379
E++ Y+ SD+WSLG L E+ PF
Sbjct: 186 EQMNRMSYNEKSDIWSLGCLLYELCALMPPF 216
>CE27768 [R] KOG0586 Serine/threonine protein kinase
Length = 1096
Score = 99.4 bits (246), Expect = 1e-20
Identities = 83/279 (29%), Positives = 128/279 (45%), Gaps = 21/279 (7%)
Query: 111 TSGSQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIW 170
T+ S S+ ++ S S PT+ SS+S +S + D+ D+
Sbjct: 62 TASSGAPAASSGGSSARYSSSGRSHPTSGSSSSHARSTGQSGMSSRSAARRNDQ---DVH 118
Query: 171 Q-TYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTI-ATIENDGSEKQIFRELQF 228
YK+ L +G+G V K A+K I T N S +++FRE++
Sbjct: 119 VGKYKL------LKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKI 172
Query: 229 NKSCKSDFIVRYYGMFACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGKIA 287
K IV+ Y + E+T +++ +EY GG D + H GR+ EK
Sbjct: 173 MKQLDHPNIVKLYQVMETEQT--LYLVLEYASGGEVFDYLVAH-----GRMKEKEARAKF 225
Query: 288 ESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGE-AVNSLATTFTGTSYYM 346
++ + YLH + IIHRD+K +N+L ++ IK+ DFG S ++ + TF G+ Y
Sbjct: 226 RQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYA 285
Query: 347 APERIQGQPYSVTS-DVWSLGLTLLEVAQGHSPFDTDKL 384
APE G+ Y DVWSLG+ L + G PFD L
Sbjct: 286 APELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNL 324
>CE23838 [R] KOG0586 Serine/threonine protein kinase
Length = 1192
Score = 99.4 bits (246), Expect = 1e-20
Identities = 83/279 (29%), Positives = 128/279 (45%), Gaps = 21/279 (7%)
Query: 111 TSGSQQSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIW 170
T+ S S+ ++ S S PT+ SS+S +S + D+ D+
Sbjct: 110 TASSGAPAASSGGSSARYSSSGRSHPTSGSSSSHARSTGQSGMSSRSAARRNDQ---DVH 166
Query: 171 Q-TYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTI-ATIENDGSEKQIFRELQF 228
YK+ L +G+G V K A+K I T N S +++FRE++
Sbjct: 167 VGKYKL------LKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKI 220
Query: 229 NKSCKSDFIVRYYGMFACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGKIA 287
K IV+ Y + E+T +++ +EY GG D + H GR+ EK
Sbjct: 221 MKQLDHPNIVKLYQVMETEQT--LYLVLEYASGGEVFDYLVAH-----GRMKEKEARAKF 273
Query: 288 ESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGE-AVNSLATTFTGTSYYM 346
++ + YLH + IIHRD+K +N+L ++ IK+ DFG S ++ + TF G+ Y
Sbjct: 274 RQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYA 333
Query: 347 APERIQGQPYSVTS-DVWSLGLTLLEVAQGHSPFDTDKL 384
APE G+ Y DVWSLG+ L + G PFD L
Sbjct: 334 APELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNL 372
>At1g54510 [R] KOG0589 Serine/threonine protein kinase
Length = 612
Score = 99.4 bits (246), Expect = 1e-20
Identities = 78/269 (28%), Positives = 124/269 (45%), Gaps = 16/269 (5%)
Query: 177 EQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATI-ENDGSEKQIFRELQFNKSCKSD 235
EQ + L +G+G+ GS + ++ K + LK I + + + +E++ +
Sbjct: 2 EQYEFLEQIGKGSFGSALLVRHKHEKKKYVLKKIRLARQTQRTRRSAHQEMELISKMRHP 61
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
FIV Y + E+ + I + Y G + K S G E+ L K +L GL
Sbjct: 62 FIVEYKDSWV-EKACYVCIVIGYCEGGDMAQAIKK--SNGVHFQEEKLCKWLVQLLMGLE 118
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAV-NSLATTFTGTSYYMAPERIQGQ 354
YLH I+HRD+K NI + I+L DFG++ + L ++ GT YM PE +
Sbjct: 119 YLHSNHILHRDVKCSNIFLTKEQDIRLGDFGLAKILTSDDLTSSVVGTPSYMCPELLADI 178
Query: 355 PYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVW 414
PY SD+WSLG + E+A F + A + I I++ P P +G+V
Sbjct: 179 PYGSKSDIWSLGCCIYEMAYLKPAFKAFDMQALINKIN--KTIVSPLPAKYSGPFRGLVK 236
Query: 415 SKSFKSFLDYSLKKDSKDRPSPRQMLQHP 443
S L+K+ + RPS +L+HP
Sbjct: 237 S---------MLRKNPEVRPSASDLLRHP 256
>SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 362
Score = 99.0 bits (245), Expect = 1e-20
Identities = 86/326 (26%), Positives = 150/326 (45%), Gaps = 48/326 (14%)
Query: 135 EPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVT 194
+P+ S TS + +++ +E D DD +S W ++G G+ G V
Sbjct: 69 QPSPISPTSTTS--EDTNTLEEDTDD-----QSIKWIRG---------ALIGSGSFGQVY 112
Query: 195 KCKLRNGSKIFALKTIATIENDGSEKQ-------IFRELQFNKSCKSDFIVRYYGMFACE 247
+ ++ A+K + S+ + + E+ + + IV+Y G
Sbjct: 113 LGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNS 172
Query: 248 ETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDI 307
+ IF+ EY+ G S+ LL+ G E ++ + L+GL YLH R I+HRDI
Sbjct: 173 DHLNIFL--EYVPGGSVAG----LLTMYGSFEETLVKNFIKQTLKGLEYLHSRGIVHRDI 226
Query: 308 KPQNILFNEIGQIKLCDFGVSGE-AVNSLAT-------TFTGTSYYMAPERIQGQPYSVT 359
K NIL + G+IK+ DFG+S + +NS +T +F G+S++MAPE ++ ++
Sbjct: 227 KGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEK 286
Query: 360 SDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFK 419
+D+WSLG ++E+ P+ P + + I + E I S S
Sbjct: 287 TDIWSLGCLVIEMLTSKHPY---------PNCDQMQAIFRIGENILPEFPSNI--SSSAI 335
Query: 420 SFLDYSLKKDSKDRPSPRQMLQHPWM 445
FL+ + D RP+ ++L HP++
Sbjct: 336 DFLEKTFAIDCNLRPTASELLSHPFV 361
>Hs14776113 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 424
Score = 99.0 bits (245), Expect = 1e-20
Identities = 78/279 (27%), Positives = 134/279 (47%), Gaps = 21/279 (7%)
Query: 174 KIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCK 233
++ + D ++G G+ V + + R + +A+K I T +G E EL+ + +
Sbjct: 93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREV-CESELRVLRRVR 151
Query: 234 SDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRG 293
I++ +F +E +++ ME G L + +++KG E+ ++ + VL G
Sbjct: 152 HANIIQLVEVFETQER--VYMVMELATGGEL---FDRIIAKGS-FTERDATRVLQMVLDG 205
Query: 294 LFYLHERKIIHRDIKPQNILFNEIG---QIKLCDFGVSG---EAVNSLATTFTGTSYYMA 347
+ YLH I HRD+KP+N+L+ G +I + DFG++ + + L T GT Y+A
Sbjct: 206 VRYLHALGITHRDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIA 265
Query: 348 PERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDE 407
PE + +PY+ + D+W+LG+ + G PF+ D L IL E
Sbjct: 266 PEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDDNRT------RLYRQILRGKYSYSGE 319
Query: 408 PEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
P + S K F+D L D R + Q L+HPW+V
Sbjct: 320 PWPSV--SNLAKDFIDRLLTVDPGARMTALQALRHPWVV 356
>Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 628
Score = 99.0 bits (245), Expect = 1e-20
Identities = 65/212 (30%), Positives = 111/212 (51%), Gaps = 11/212 (5%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIAT--IENDGSEKQIFRELQFNK 230
+ + + + L LG+GT G V K + +G ++ A+K+I I+++ I RE++
Sbjct: 47 HNLRHRYEFLETLGKGTYGKVKKARESSG-RLVAIKSIRKDKIKDEQDLMHIRREIEIMS 105
Query: 231 SCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESV 290
S I+ + +F E +S I I MEY S +Y ++ S+ ++ E+ +
Sbjct: 106 SLNHPHIIAIHEVF--ENSSKIVIVMEYA---SRGDLYDYI-SERQQLSEREARHFFRQI 159
Query: 291 LRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSG-EAVNSLATTFTGTSYYMAPE 349
+ + Y H+ +++HRD+K +NIL + G IK+ DFG+S TF G+ Y +PE
Sbjct: 160 VSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPE 219
Query: 350 RIQGQPYSVTS-DVWSLGLTLLEVAQGHSPFD 380
+ G+PY+ D WSLG+ L + G PFD
Sbjct: 220 IVNGKPYTGPEVDSWSLGVLLYILVHGTMPFD 251
>SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1401
Score = 98.6 bits (244), Expect = 2e-20
Identities = 79/249 (31%), Positives = 111/249 (43%), Gaps = 32/249 (12%)
Query: 221 QIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRI-G 279
QI E+ + +V YYG+ E ++I ME+ G SL + H GRI
Sbjct: 1082 QIHNEMTVLERLNHPNVVTYYGVEVHREK--VYIFMEFCQGGSLADLLAH-----GRIED 1134
Query: 280 EKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFG------------V 327
E VL +L GL Y+H + I+HRDIKP NIL + G IK DFG V
Sbjct: 1135 ENVLKVYVVQLLEGLAYIHSQHILHRDIKPANILLDHRGMIKYSDFGSALYVSPPTDPEV 1194
Query: 328 SGEAVNSLATTFTGTSYYMAPERIQGQPYS--VTSDVWSLGLTLLEVAQGHSPF-DTDKL 384
E + GT YMAPE I G D+WSLG +LE+ G +P+ + D
Sbjct: 1195 RYEDIQPELQHLAGTPMYMAPEIILGTKKGDFGAMDIWSLGCVILEMMTGSTPWSEMDNE 1254
Query: 385 AANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPW 444
A M + + TP + Q S + F++ ++D + RP +L HPW
Sbjct: 1255 WAIMYHVAAM-----HTPSI----PQNEKISSLARDFIEQCFERDPEQRPRAVDLLTHPW 1305
Query: 445 MVGQTKKHV 453
+ KK +
Sbjct: 1306 ITDFRKKTI 1314
>HsM4505191 [T] KOG0607 MAP kinase-interacting kinase and related
serine/threonine protein kinases
Length = 424
Score = 98.6 bits (244), Expect = 2e-20
Identities = 89/321 (27%), Positives = 139/321 (42%), Gaps = 47/321 (14%)
Query: 158 RDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDG 217
R +TD L YK+ T +LGEG V K +A+K I +
Sbjct: 33 RGRATDSLPGKFEDMYKL-----TSELLGEGAYAKVQGAVSLQNGKEYAVKIIEK-QAGH 86
Query: 218 SEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGR 277
S ++FRE++ C+ + + F ++T + + GG S+ H+ K
Sbjct: 87 SRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGG----SILAHI-QKQKH 141
Query: 278 IGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILF---NEIGQIKLCDFGV-SGEAVN 333
E+ ++ V L +LH + I HRD+KP+NIL ++ +K+CDF + SG +N
Sbjct: 142 FNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLN 201
Query: 334 SLATTFT--------GTSYYMAPERI-----QGQPYSVTSDVWSLGLTLLEVAQGHSPF- 379
+ T T G++ YMAPE + Q Y D+WSLG+ L + G+ PF
Sbjct: 202 NSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFV 261
Query: 380 ------------DTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLK 427
+ ++ N +L I E D+ I S K + L
Sbjct: 262 GHCGADCGWDRGEVCRVCQN----KLFESIQEGKYEFPDKDWAHI--SSEAKDLISKLLV 315
Query: 428 KDSKDRPSPRQMLQHPWMVGQ 448
+D+K R S Q+LQHPW+ GQ
Sbjct: 316 RDAKQRLSAAQVLQHPWVQGQ 336
>Hs7661974 [T] KOG0583 Serine/threonine protein kinase
Length = 651
Score = 98.6 bits (244), Expect = 2e-20
Identities = 81/287 (28%), Positives = 135/287 (46%), Gaps = 36/287 (12%)
Query: 168 DIWQTYKIHEQIDTLGILGEGTGGSVT---KCKLRNGSKIFALKTIATIENDGSEKQIFR 224
++ + Y++HE I GTGG C + G + A+K + +I
Sbjct: 6 ELLKYYELHETI--------GTGGFAKVKLACHILTGEMV-AIKIMDKNTLGSDLPRIKT 56
Query: 225 ELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLG 284
E++ K+ + I + Y + E + IF+ +EY G L + +++S+ R+ E+
Sbjct: 57 EIEALKNLRHQHICQLYHVL--ETANKIFMVLEYCPGGEL---FDYIISQD-RLSEEETR 110
Query: 285 KIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSL---ATTFTG 341
+ ++ + Y+H + HRD+KP+N+LF+E ++KL DFG+ + + T G
Sbjct: 111 VVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCG 170
Query: 342 TSYYMAPERIQGQPY-SVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTF 400
+ Y APE IQG+ Y +DVWS+G+ L + G PFD D + A L
Sbjct: 171 SLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMA---------LYKKI 221
Query: 401 TPELKDEPEQGIVW-SKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMV 446
D P+ W S S L L+ D K R S + +L HPW++
Sbjct: 222 MRGKYDVPK----WLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIM 264
>At3g20860 [R] KOG0589 Serine/threonine protein kinase
Length = 427
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/273 (27%), Positives = 125/273 (45%), Gaps = 23/273 (8%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATI-ENDGSEKQIFRELQFNKS 231
Y++ EQI G G GS ++ + + +K I + + + +E+
Sbjct: 15 YEVVEQI------GRGAFGSAFLVIHKSERRKYVVKKIRLAKQTERCKLAAIQEMSLISK 68
Query: 232 CKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVL 291
KS +IV Y + E + I Y G + + K S+G E+ L + +L
Sbjct: 69 LKSPYIVEYKDSWV--EKDCVCIVTSYCEGGDMTQMIKK--SRGVFASEEKLCRWMVQLL 124
Query: 292 RGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGE-AVNSLATTFTGTSYYMAPER 350
+ YLH +++HRD+K NI + +++L DFG++ + LA++ GT YM PE
Sbjct: 125 LAIDYLHNNRVLHRDLKCSNIFLTKENEVRLGDFGLAKLLGKDDLASSMVGTPNYMCPEL 184
Query: 351 IQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQ 410
+ PY SD+WSLG + EVA F +AA + I L P
Sbjct: 185 LADIPYGYKSDIWSLGCCMFEVAAHQPAFKAPDMAALINKIN--------RSSLSPLP-- 234
Query: 411 GIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHP 443
+++S S K + L+K+ + RP+ ++L+HP
Sbjct: 235 -VMYSSSLKRLIKSMLRKNPEHRPTAAELLRHP 266
>7304283 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 7175
Score = 98.6 bits (244), Expect = 2e-20
Identities = 69/291 (23%), Positives = 135/291 (45%), Gaps = 20/291 (6%)
Query: 175 IHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKS 234
++++ D L +G G G V +C+ R+ IFA K I + + + I RE+
Sbjct: 6134 VYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIP-VSHSVEKDLIRREIDIMNQLHH 6192
Query: 235 DFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGL 294
++ + F E+ + + +E++ G L ++ + ++G + E + + G+
Sbjct: 6193 QKLINLHDAF--EDDDEMILILEFLSGGEL---FERITAEGYVMTEAEVINYMRQICEGI 6247
Query: 295 FYLHERKIIHRDIKPQNILFNEIGQ--IKLCDFGVSGEA-VNSLATTFTGTSYYMAPERI 351
++HE+ IIH DIKP+NI+ +KL DFG++ N + TGT+ + APE +
Sbjct: 6248 RHMHEQNIIHLDIKPENIMCQTRSSTNVKLIDFGLATRLDPNEVVKITTGTAEFAAPEIV 6307
Query: 352 QGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQG 411
+P +D+W+ G+ + G SPF D + ++ + + E
Sbjct: 6308 NREPVGFYTDMWATGVLSYVLLSGLSPFAGDNDVQTLKNVKAC--------DWDFDVESF 6359
Query: 412 IVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ---TKKHVNMKKFI 459
S+ K F+ L ++ + R + + L HPW+ G K+ +N +++
Sbjct: 6360 KYISEEAKDFIRKLLVRNKEKRMTAHECLLHPWLTGDHSAMKQEINRDRYL 6410
>Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase
Length = 292
Score = 98.6 bits (244), Expect = 2e-20
Identities = 77/273 (28%), Positives = 125/273 (45%), Gaps = 23/273 (8%)
Query: 182 LGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIF-RELQFNKSCKSDFIVRY 240
L ++G+G+ G VT K R K + +K + E++ +E Q K IV Y
Sbjct: 9 LRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTY 68
Query: 241 YGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
+ + ++I M + G L K KG + E + + + L YLHE+
Sbjct: 69 KESWEGGD-GLLYIVMGFCEGGDLYRKLKE--QKGQLLPENQVVEWFVQIAMALQYLHEK 125
Query: 301 KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVN--SLATTFTGTSYYMAPERIQGQPYSV 358
I+HRD+K QN+ IK+ D G++ N +A+T GT YYM+PE +PY+
Sbjct: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
Query: 359 TSDVWSLGLTLLEVAQGHSPF---DTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWS 415
SDVW+LG + E+A F D + L + +L + ++PEL +
Sbjct: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPAMPRDYSPELAE--------- 236
Query: 416 KSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVGQ 448
+ L K ++RPS R +L+ P++ Q
Sbjct: 237 -----LIRTMLSKRPEERPSVRSILRQPYIKRQ 264
>Hs6912584 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 451
Score = 98.2 bits (243), Expect = 2e-20
Identities = 81/268 (30%), Positives = 130/268 (48%), Gaps = 16/268 (5%)
Query: 116 QSTQSADSMTSNLISMYDSEPTTSSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKI 175
QST +N + SE + + GKES + R S S +
Sbjct: 59 QSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVR--RHSSPSSPTSPKFGKADS 116
Query: 176 HEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSCKSD 235
+E+++ LG EG+ +V K K + K+ ALK I E +G+ RE K K
Sbjct: 117 YEKLEKLG---EGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHA 173
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
IV + + +ET T+ EY+ + KH GG + V + + +LRGL
Sbjct: 174 NIVLLHDIIHTKETLTL--VFEYVHTDLCQYMDKH---PGGLHPDNVKLFLFQ-LLRGLS 227
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATTFTG---TSYYMAPERIQ 352
Y+H+R I+HRD+KPQN+L ++ G++KL DFG++ A + + T++ T +Y P+ +
Sbjct: 228 YIHQRYILHRDLKPQNLLISDTGELKLADFGLA-RAKSVPSHTYSNEVVTLWYRPPDVLL 286
Query: 353 GQ-PYSVTSDVWSLGLTLLEVAQGHSPF 379
G YS D+W +G +E+ QG + F
Sbjct: 287 GSTEYSTCLDMWGVGCIFVEMIQGVAAF 314
>Hs4506067 [T] KOG0696 Serine/threonine protein kinase
Length = 672
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/204 (30%), Positives = 103/204 (49%), Gaps = 11/204 (5%)
Query: 182 LGILGEGTGGSVTKCKLRNGSKIFALKTI---ATIENDGSEKQIFRELQFNKSCKSDFIV 238
L +LG+G+ G V + +++A+K + I++D E + + K F+
Sbjct: 342 LMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLT 401
Query: 239 RYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLH 298
+ + F + ++ MEY+ G L + + + G+ E A + GLF+LH
Sbjct: 402 QLHSCF--QTVDRLYFVMEYVNGGDL----MYHIQQVGKFKEPQAVFYAAEISIGLFFLH 455
Query: 299 ERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLAT--TFTGTSYYMAPERIQGQPY 356
+R II+RD+K N++ + G IK+ DFG+ E + T TF GT Y+APE I QPY
Sbjct: 456 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY 515
Query: 357 SVTSDVWSLGLTLLEVAQGHSPFD 380
+ D W+ G+ L E+ G PFD
Sbjct: 516 GKSVDWWAYGVLLYEMLAGQPPFD 539
>Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 302
Score = 98.2 bits (243), Expect = 2e-20
Identities = 54/163 (33%), Positives = 83/163 (50%), Gaps = 4/163 (2%)
Query: 224 RELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVL 283
+E+ K +++YY F E + + I +E L + KH + I E+ +
Sbjct: 81 KEIDLLKQLNHPNVIKYYASFI--EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTV 138
Query: 284 GKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSG--EAVNSLATTFTG 341
K + L ++H R+++HRDIKP N+ G +KL D G+ + + A + G
Sbjct: 139 WKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVG 198
Query: 342 TSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKL 384
T YYM+PERI Y+ SD+WSLG L E+A SPF DK+
Sbjct: 199 TPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKM 241
>CE28218 [D] KOG0588 Serine/threonine protein kinase
Length = 914
Score = 98.2 bits (243), Expect = 2e-20
Identities = 87/332 (26%), Positives = 152/332 (45%), Gaps = 35/332 (10%)
Query: 139 SSSTSLVNHGKESEIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSV-TKCK 197
+S + VN+ S+I+ + + ++ YK+ + LG+G G V T
Sbjct: 13 NSKLAAVNNELSSKIMSENIVSTRPVAQAQYCGPYKLEKT------LGKGQTGLVKTGTH 66
Query: 198 LRNGSKIFALKTIATIENDGSEKQ-IFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAM 256
G K+ A+K + + S Q + RE+ K + ++ Y ++ E +++ +
Sbjct: 67 CITGRKV-AIKIVNKEKLSESVLQKVEREIAIMKLIEHPHVLHLYDVY--ENKKYLYLLL 123
Query: 257 EYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNE 316
E++ G L + +L+ KG R+ K K ++ L + H I HRD+KP+N+L +E
Sbjct: 124 EHVSGGEL---FDYLVRKG-RLMSKEARKFFRQIISALDFCHAHNICHRDLKPENLLLDE 179
Query: 317 IGQIKLCDFGVSG-EAVNSLATTFTGTSYYMAPERIQGQPY-SVTSDVWSLGLTLLEVAQ 374
IK+ DFG++ + S+ T G+ +Y PE I+G+ Y +DVWS G+ L +
Sbjct: 180 RNNIKVADFGMASLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLV 239
Query: 375 GHSPFDTDKLAANMPPIEL-LMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDR 433
G PFD D L + ++ + I F P +S L ++ D R
Sbjct: 240 GALPFDDDNLRNLLEKVKRGVFHIPHFVP-------------ADVQSLLRAMIEVDPGKR 286
Query: 434 PSPRQMLQHPWMVGQTKK----HVNMKKFIQT 461
S + +HPW+ G TK + M + +QT
Sbjct: 287 YSLADVFKHPWVSGTTKADPELELPMSQVVQT 318
>At3g56760 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 577
Score = 98.2 bits (243), Expect = 2e-20
Identities = 84/292 (28%), Positives = 135/292 (45%), Gaps = 46/292 (15%)
Query: 176 HEQIDTLGILGEGTGGSVTKCKLRNGS--------KIFA---LKTIATIENDGSEKQIFR 224
H +ID G +G G G K + GS K+ + T IE+ E +I R
Sbjct: 123 HYEID--GEVGRGHFGYTCSAKGKKGSLKGQDVAVKVIPKSKMTTAIAIEDVRREVKILR 180
Query: 225 ELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEY-MGGRSLDSVYKHLLSKGGRIGEKVL 283
L +K+ +V++Y F E+ ++I ME GG LD + L +GG+ E
Sbjct: 181 ALTGHKN-----LVQFYDAF--EDDENVYIVMELCQGGELLDKI----LQRGGKYSEVDA 229
Query: 284 GKIAESVLRGLFYLHERKIIHRDIKPQNILF---NEIGQIKLCDFGVS-----GEAVNSL 335
K+ +L + Y H + ++HRD+KP+N LF +E +K DFG+S E +N +
Sbjct: 230 KKVMIQILSVVAYCHLQGVVHRDLKPENFLFTTKDESSPLKAIDFGLSDYVRPDERLNDI 289
Query: 336 ATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLM 395
G++YY+APE + + Y +D+WS+G+ + G PF + +
Sbjct: 290 ----VGSAYYVAPE-VLHRTYGTEADMWSIGVIAYILLCGSRPFWARSESG------IFR 338
Query: 396 LILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVG 447
+L P ++ P + S F+ L KD + R + Q L HPW+VG
Sbjct: 339 AVLKAEPNFEEAPWPSL--SPDAVDFVKRLLNKDYRKRLTAAQALCHPWLVG 388
>At2g41140 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 576
Score = 98.2 bits (243), Expect = 2e-20
Identities = 83/292 (28%), Positives = 135/292 (45%), Gaps = 46/292 (15%)
Query: 176 HEQIDTLGILGEGTGGSVTKCKLRNGS--------KIFA---LKTIATIENDGSEKQIFR 224
H +ID G +G G G K + GS K+ + T IE+ E ++ R
Sbjct: 122 HYEID--GEVGRGHFGYTCSAKGKKGSLKGQEVAVKVIPKSKMTTAIAIEDVSREVKMLR 179
Query: 225 ELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVL 283
L +K+ +V++Y F E+ ++I ME GG LD + L +GG+ E
Sbjct: 180 ALTGHKN-----LVQFYDAF--EDDENVYIVMELCKGGELLDKI----LQRGGKYSEDDA 228
Query: 284 GKIAESVLRGLFYLHERKIIHRDIKPQNILF---NEIGQIKLCDFGVS-----GEAVNSL 335
K+ +L + Y H + ++HRD+KP+N LF +E +K DFG+S E +N +
Sbjct: 229 KKVMVQILSVVAYCHLQGVVHRDLKPENFLFSTKDETSPLKAIDFGLSDYVKPDERLNDI 288
Query: 336 ATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLM 395
G++YY+APE + + Y +D+WS+G+ + G PF + +
Sbjct: 289 ----VGSAYYVAPE-VLHRTYGTEADMWSIGVIAYILLCGSRPFWARTESG------IFR 337
Query: 396 LILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWMVG 447
+L P ++ P + S F+ L KD + R + Q L HPW+VG
Sbjct: 338 AVLKAEPNFEEAPWPSL--SPEAVDFVKRLLNKDYRKRLTAAQALCHPWLVG 387
>7299322 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 434
Score = 98.2 bits (243), Expect = 2e-20
Identities = 70/207 (33%), Positives = 104/207 (49%), Gaps = 10/207 (4%)
Query: 178 QIDTLGILGEGTGGSVTKCKLRNGSKIFALKTI--ATIENDGSEKQIFRELQFNKSCKSD 235
+ D + LG+GT G V + + A+KTI IE + +I RE+Q S
Sbjct: 81 KFDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHP 140
Query: 236 FIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLF 295
I+ Y +F E + + ME+ G L Y +L S+ + E+ +I V ++
Sbjct: 141 NIIHIYEVF--ENREKMVLVMEFAAGGEL---YDYL-SERKVLTEEEARRIFRQVATAVY 194
Query: 296 YLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNS-LATTFTGTSYYMAPERIQGQ 354
Y H+ KI HRD+K +NIL +E G K+ DFG+S + L TF G+ Y +PE ++G
Sbjct: 195 YCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGT 254
Query: 355 PYSVTS-DVWSLGLTLLEVAQGHSPFD 380
PY D WSLG+ L + G PFD
Sbjct: 255 PYQGPEVDCWSLGVLLYTLVYGSMPFD 281
>Hs4758192 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 414
Score = 97.8 bits (242), Expect = 3e-20
Identities = 76/269 (28%), Positives = 130/269 (48%), Gaps = 22/269 (8%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATI-ENDGSEKQIFRELQFNKSCKSD-FIVRYYG 242
LG G V KC ++ K FA K + + +I E+ + + + +++ +
Sbjct: 67 LGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHE 126
Query: 243 MFACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERK 301
++ E S + + +EY GG D + + EK + ++ +L G+ +LH R
Sbjct: 127 VY--ETASEMILVLEYAAGGEIFDQC---VADREEAFKEKDVQRLMRQILEGVHFLHTRD 181
Query: 302 IIHRDIKPQNILF---NEIGQIKLCDFGVSGEAVNS-LATTFTGTSYYMAPERIQGQPYS 357
++H D+KPQNIL + +G IK+ DFG+S NS GT Y+APE + P S
Sbjct: 182 VVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPIS 241
Query: 358 VTSDVWSLGLTLLEVAQGHSPF-DTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSK 416
+ +D+WS+G+ + G SPF DK + + + L+++ E D V S+
Sbjct: 242 MATDMWSIGVLTYVMLTGISPFLGNDKQETF---LNISQMNLSYSEEEFD------VLSE 292
Query: 417 SFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
S F+ L K +DR + + L+HPW+
Sbjct: 293 SAVDFIRTLLVKKPEDRATAEECLKHPWL 321
>Hs4506785 [T] KOG0660 Mitogen-activated protein kinase
Length = 367
Score = 97.8 bits (242), Expect = 3e-20
Identities = 81/306 (26%), Positives = 146/306 (47%), Gaps = 35/306 (11%)
Query: 164 ELESDIWQTYKIHEQIDTLGILGEGTGGSVTKC-KLRNGSKIFALKTIATIENDGSEKQI 222
E+ W+ ++ + +G G G+V R G+K+ K +++ K+
Sbjct: 15 EVTKTAWEVRAVYRDLQPVG---SGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRA 71
Query: 223 FRELQFNKSCKSDFIVRYYGMFACEET----STIFIAMEYMGGRSLDSVYKHLLSKGGRI 278
+REL+ K + + ++ +F +ET + ++ M +MG L + KH ++
Sbjct: 72 YRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMG-TDLGKLMKH-----EKL 125
Query: 279 GEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLCDFGVSGEAVNSLATT 338
GE + + +L+GL Y+H IIHRD+KP N+ NE ++K+ DFG++ +A +S T
Sbjct: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQA-DSEMTG 184
Query: 339 FTGTSYYMAPERI-QGQPYSVTSDVWSLGLTLLEVAQGHSPF----DTDKLAANM----- 388
+ T +Y APE I Y+ T D+WS+G + E+ G + F D+L M
Sbjct: 185 YVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGT 244
Query: 389 PPIELLMLI--------LTFTPELKDEPEQGIVWSKS--FKSFLDYSLKKDSKDRPSPRQ 438
PP E + + + PEL+ + I+ + S + L+ L D++ R + +
Sbjct: 245 PPAEFVQRLQSDEAKNNMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGE 304
Query: 439 MLQHPW 444
L HP+
Sbjct: 305 ALAHPY 310
>Hs4506055 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 351
Score = 97.8 bits (242), Expect = 3e-20
Identities = 75/271 (27%), Positives = 133/271 (48%), Gaps = 36/271 (13%)
Query: 152 EIIEHDRDDSTDELESDIWQTYKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTI- 210
E + ++D + ES T + +Q + + LG G+ G V K + +A+K +
Sbjct: 18 EFLAKAKEDFLKKWESPAQNTAHL-DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILD 76
Query: 211 -------ATIENDGSEKQIFRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYMGGRS 263
IE+ +EK+I + + F F+V+ F+ ++ S +++ MEY+ G
Sbjct: 77 KQKVVKLKQIEHTLNEKRILQAVNF------PFLVKLE--FSFKDNSNLYMVMEYVPGGE 128
Query: 264 LDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKIIHRDIKPQNILFNEIGQIKLC 323
+ S + + GR E A ++ YLH +I+RD+KP+N+L ++ G I++
Sbjct: 129 MFSHLRRI----GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVT 184
Query: 324 DFGVSGEAVNSLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDK 383
DFG + + V T GT Y+APE I + Y+ D W+LG+ + E+A G+ PF D+
Sbjct: 185 DFGFA-KRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQ 243
Query: 384 LAANMPPIELLMLILT--------FTPELKD 406
PI++ I++ F+ +LKD
Sbjct: 244 ------PIQIYEKIVSGKVRFPSHFSSDLKD 268
>At1g49580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 606
Score = 97.8 bits (242), Expect = 3e-20
Identities = 82/292 (28%), Positives = 138/292 (47%), Gaps = 44/292 (15%)
Query: 174 KIHEQIDTLGILGEGTGGSVTKCKLRNGS---KIFALK--------TIATIENDGSEKQI 222
+ H +++ +G G G K + G ++ A+K T IE+ E +I
Sbjct: 145 EFHSRVELGEEIGRGHFGYTCSAKFKKGELKGQVVAVKIIPKSKMTTAIAIEDVRREVKI 204
Query: 223 FRELQFNKSCKSDFIVRYYGMFACEETSTIFIAMEYM-GGRSLDSVYKHLLSKGGRIGEK 281
+ L +K+ +V++Y F E+ + ++IAME GG LD + L++GG+ E
Sbjct: 205 LQALSGHKN-----LVQFYDAF--EDNANVYIAMELCEGGELLDRI----LARGGKYSEN 253
Query: 282 VLGKIAESVLRGLFYLHERKIIHRDIKPQNILF---NEIGQIKLCDFGVS-----GEAVN 333
+ +L + + H + ++HRD+KP+N L+ E Q+K DFG+S E +N
Sbjct: 254 DAKPVIIQILNVVAFCHFQGVVHRDLKPENFLYTSKEENSQLKAIDFGLSDFVRPDERLN 313
Query: 334 SLATTFTGTSYYMAPERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIEL 393
+ G++YY+APE + + Y+ +DVWS+G+ + G PF + +
Sbjct: 314 DI----VGSAYYVAPE-VLHRSYTTEADVWSIGVIAYILLCGSRPFWARTESG------I 362
Query: 394 LMLILTFTPELKDEPEQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
+L P DEP + S K F+ L KD + R S Q L HPW+
Sbjct: 363 FRAVLKADPSF-DEPPWPFL-SSDAKDFVKRLLFKDPRRRMSASQALMHPWI 412
>YPL209c [D] KOG0580 Serine/threonine protein kinase
Length = 367
Score = 97.4 bits (241), Expect = 4e-20
Identities = 78/265 (29%), Positives = 119/265 (44%), Gaps = 21/265 (7%)
Query: 185 LGEGTGGSVTKCKLRNGSKIFALKTIATIE--NDGSEKQIFRELQFNKSCKSDFIVRYYG 242
LG+G G V + R+ I ALK + E +KQ RE++ S + + YG
Sbjct: 110 LGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLNHPNLTKSYG 169
Query: 243 MFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHERKI 302
F E+ +++ MEY+ + YK LL G + + + L Y+H++ I
Sbjct: 170 YFHDEKR--VYLLMEYLVNGEM---YK-LLRLHGPFNDILASDYIYQIANALDYMHKKNI 223
Query: 303 IHRDIKPQNILFNEIGQIKLCDFGVS-GEAVNSLATTFTGTSYYMAPERIQGQPYSVTSD 361
IHRDIKP+NIL IKL DFG S + T GT Y++PE ++ + Y T D
Sbjct: 224 IHRDIKPENILIGFNNVIKLTDFGWSIINPPENRRKTVCGTIDYLSPEMVESREYDHTID 283
Query: 362 VWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEPEQGIVWSKSFKSF 421
W+LG+ E+ G PF+ + I L + + P + Q ++
Sbjct: 284 AWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIKM---PSNISQDAQDLILK------ 334
Query: 422 LDYSLKKDSKDRPSPRQMLQHPWMV 446
LK D KDR + HPW++
Sbjct: 335 ---LLKYDPKDRMRLGDVKMHPWIL 356
>Hs14735945 [T] KOG0694 Serine/threonine protein kinase
Length = 676
Score = 97.4 bits (241), Expect = 4e-20
Identities = 65/204 (31%), Positives = 105/204 (50%), Gaps = 11/204 (5%)
Query: 184 ILGEGTGGSVTKCKLRNGSKIFALKTI---ATIENDGSEKQIFRELQFNKSCKSDFIVRY 240
+LG+G+ G V +L+ + FA+K + + +D E + + + ++ F+
Sbjct: 354 VLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHL 413
Query: 241 YGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLRGLFYLHER 300
F ++ +F ME++ G L H+ KG R A ++ GL +LH +
Sbjct: 414 ICTFQTKDH--LFFVMEFLNGGDL---MYHIQDKG-RFELYRATFYAAEIMCGLQFLHSK 467
Query: 301 KIIHRDIKPQNILFNEIGQIKLCDFGVSGEAV--NSLATTFTGTSYYMAPERIQGQPYSV 358
II+RD+K N+L + G IK+ DFG+ E + S A+TF GT Y+APE +QG Y+
Sbjct: 468 GIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTF 527
Query: 359 TSDVWSLGLTLLEVAQGHSPFDTD 382
+ D WS G+ L E+ G SPF D
Sbjct: 528 SVDWWSFGVLLYEMLIGQSPFHGD 551
>CE06635 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 7160
Score = 97.4 bits (241), Expect = 4e-20
Identities = 75/277 (27%), Positives = 131/277 (47%), Gaps = 25/277 (9%)
Query: 173 YKIHEQIDTLGILGEGTGGSVTKCKLRNGSKIFALKTIATIENDGSEKQIFRELQFNKSC 232
Y IHE+ LG G G V + R FA K + T ++ ++ + +E+Q
Sbjct: 6263 YDIHEE------LGTGAFGVVHRVTERATGNNFAAKFVMT-PHESDKETVRKEIQTMSVL 6315
Query: 233 KSDFIVRYYGMFACEETSTIFIAMEYMGGRSLDSVYKHLLSKGGRIGEKVLGKIAESVLR 292
+ +V + F E+ + + + E+M G L ++ + + ++ E + V +
Sbjct: 6316 RHPTLVNLHDAF--EDDNEMVMIYEFMSGGEL---FEKVADEHNKMSEDEAVEYMRQVCK 6370
Query: 293 GLFYLHERKIIHRDIKPQNILFN--EIGQIKLCDFGVSG--EAVNSLATTFTGTSYYMAP 348
GL ++HE +H D+KP+NI+F ++KL DFG++ + S+ T TGT+ + AP
Sbjct: 6371 GLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVT-TGTAEFAAP 6429
Query: 349 ERIQGQPYSVTSDVWSLGLTLLEVAQGHSPFDTDKLAANMPPIELLMLILTFTPELKDEP 408
E +G+P +D+WS+G+ + G SPF + E L + + + D
Sbjct: 6430 EVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGEN------DDETLRNVKSCDWNMDDSA 6483
Query: 409 EQGIVWSKSFKSFLDYSLKKDSKDRPSPRQMLQHPWM 445
GI S+ K F+ L D R + Q L+HPW+
Sbjct: 6484 FSGI--SEDGKDFIRKLLLADPNTRMTIHQALEHPWL 6518
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.132 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,331,939
Number of Sequences: 60738
Number of extensions: 1059093
Number of successful extensions: 8204
Number of sequences better than 1.0e-05: 1691
Number of HSP's better than 0.0 without gapping: 323
Number of HSP's successfully gapped in prelim test: 1368
Number of HSP's that attempted gapping in prelim test: 5056
Number of HSP's gapped (non-prelim): 1933
length of query: 465
length of database: 30,389,216
effective HSP length: 110
effective length of query: 355
effective length of database: 23,708,036
effective search space: 8416352780
effective search space used: 8416352780
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)