ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV1831 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV1831 631894 630098 -599
(599 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIL166c [G] KOG2533 Permease of the major facilitator superfamily 455 e-128
YOL163w [G] KOG2533 Permease of the major facilitator superfamily 226 1e-58
YOL162w [G] KOG2533 Permease of the major facilitator superfamily 210 4e-54
SPAC1039.04 [G] KOG2533 Permease of the major facilitator superf... 153 6e-37
SPAC1002.16c [G] KOG2533 Permease of the major facilitator super... 150 7e-36
YGR260w [G] KOG2533 Permease of the major facilitator superfamily 137 6e-32
SPAC11D3.18c [G] KOG2533 Permease of the major facilitator super... 136 1e-31
SPCC417.10 [G] KOG2533 Permease of the major facilitator superfa... 131 3e-30
SPBC1683.12 [G] KOG2533 Permease of the major facilitator superf... 129 1e-29
SPCC757.13 [G] KOG2533 Permease of the major facilitator superfa... 118 2e-26
SPCPB1C11.03 [G] KOG2533 Permease of the major facilitator super... 115 1e-25
SPBPB10D8.01 [G] KOG2533 Permease of the major facilitator super... 114 4e-25
YLL055w [G] KOG2533 Permease of the major facilitator superfamily 113 9e-25
YAL067c [G] KOG2533 Permease of the major facilitator superfamily 108 2e-23
YLR004c [G] KOG2533 Permease of the major facilitator superfamily 105 3e-22
YJR152w [G] KOG2533 Permease of the major facilitator superfamily 98 4e-20
SPBC1773.15 [G] KOG2533 Permease of the major facilitator superf... 97 9e-20
YGR065c [G] KOG2533 Permease of the major facilitator superfamily 88 4e-17
SPBC2G2.01c [G] KOG2533 Permease of the major facilitator superf... 87 6e-17
SPAC1B3.15c [G] KOG2533 Permease of the major facilitator superf... 74 5e-13
SPAC1B3.16c [G] KOG2533 Permease of the major facilitator superf... 70 9e-12
YCR028c [G] KOG2533 Permease of the major facilitator superfamily 64 5e-10
>YIL166c [G] KOG2533 Permease of the major facilitator superfamily
Length = 542
Score = 455 bits (1171), Expect = e-128
Identities = 231/523 (44%), Positives = 331/523 (63%), Gaps = 9/523 (1%)
Query: 83 SQDSLTSD------NPFSDPKIAEYYRALYDDSKYESRSAFDPEFTWTKEEEQKVVRKLN 136
S +SLTSD NPF D AE +R +Y+ S YE S FDPEFTWTK+EE+K+VRK++
Sbjct: 19 SAESLTSDSESISHNPFDDFHKAERWRKVYESSGYEGLSKFDPEFTWTKDEEKKLVRKMD 78
Query: 137 IRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIFYISFLLAEIPSQL 196
+++ L +F L L R N+++AV DN + DL MN NDYNLG ++ + FL +E+P L
Sbjct: 79 LKIFLWVFIMFAFLDLIRKNIARAVSDNFIVDLKMNTNDYNLGQTVYLVIFLASELPGNL 138
Query: 197 ISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIGALEGGFIADLVLWLTYFF 256
+SKR GP+ IP+QI WSV+ + QA + N+ F RCL+G ++GGFI D +L+L+Y++
Sbjct: 139 LSKRFGPERVIPVQIVLWSVICITQAGLKNRGQFIATRCLLGMVQGGFIPDNILYLSYYY 198
Query: 257 TSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAGWQYLFLLEGILTFFIGLTG 316
T E + RLS+FW ++ L QIL ++LA GI+ MRGI LAGWQYLF++EG L+ +G+
Sbjct: 199 TGAELTFRLSFFWCAIPLFQILGSLLASGIIEMRGIHNLAGWQYLFIIEGFLSLSVGVAS 258
Query: 317 FYLMVPSAVQTKNWMHPKG--WFTEREEKIVVNRVLRDDPSKGDMHNRQPISFKLIWSAI 374
FYLM QT KG FTE EEKI+VNR+LRDDPSKGDM NRQP++FK I +
Sbjct: 259 FYLMRRGPTQTGESAFHKGKSLFTEYEEKIMVNRILRDDPSKGDMSNRQPVTFKEILYTL 318
Query: 375 SDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKSVGFSTFNVQLLSIPYQVIHIIFLLGITW 434
+++DLWP++ G+ A++ KS+ +STF +L+IP Q + +I L
Sbjct: 319 TEFDLWPLFIQGITAFISLQTVGSYLSLILKSLNYSTFLSNILAIPGQALLLINLPLAAL 378
Query: 435 FSERVKQRAYMGIISAVWNAFFLAILRWWKGSLVEAWPTFALCTLLLGSPYVHAICVSWV 494
S ++K+++ I+ VW F+ L W + L T +LG PY H+I WV
Sbjct: 379 LSRKLKEKSLCVGIANVWVLPFIVSLVALPTD-TNPWIKYILLTGILGLPYTHSILAGWV 437
Query: 495 SRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDKPLYHTGNTVLFSLAVVTTPIFLF 554
S SNS+++R + +ALYNM+ QVGAI ++ +YR +DKP Y GN +L + +
Sbjct: 438 SEISNSVRSRTVGTALYNMSAQVGAIIASNMYRNDDKPYYTRGNKILLGFTCFNICMAVA 497
Query: 555 VKWYYHKRNKDKEAIWSKMSEDERIEYIHNTTDTANKRLDFRF 597
K+YY RNK K+ W+ M+++E+I Y+ T D KRLD+RF
Sbjct: 498 TKFYYISRNKYKDRKWNSMTKEEQINYLDTTKDKGMKRLDYRF 540
>YOL163w [G] KOG2533 Permease of the major facilitator superfamily
Length = 169
Score = 226 bits (575), Expect = 1e-58
Identities = 99/165 (60%), Positives = 133/165 (80%)
Query: 213 SWSVVAMAQAAMHNKTGFFICRCLIGALEGGFIADLVLWLTYFFTSKEFSIRLSWFWTSL 272
+WS+VA Q M K+ F+ CR L+G EGGF+ADLVLW++YF++S E SIRLS+FW +L
Sbjct: 3 AWSLVATLQCKMTGKSSFYTCRALMGLFEGGFVADLVLWMSYFYSSSELSIRLSFFWVTL 62
Query: 273 SLVQILSAILAYGILRMRGIGGLAGWQYLFLLEGILTFFIGLTGFYLMVPSAVQTKNWMH 332
SL QI+++I+A+G+ MRGIGG+AGWQ+LFL+E I T IG++ ++LMVPS VQTK
Sbjct: 63 SLTQIITSIVAFGVFHMRGIGGMAGWQWLFLIERIFTLVIGISAYFLMVPSVVQTKKPWS 122
Query: 333 PKGWFTEREEKIVVNRVLRDDPSKGDMHNRQPISFKLIWSAISDY 377
KGWFTEREEKI+VN++LRDDP+KGDM+NRQ +S K++W I+DY
Sbjct: 123 KKGWFTEREEKIIVNKILRDDPTKGDMNNRQGMSLKMLWQGITDY 167
>YOL162w [G] KOG2533 Permease of the major facilitator superfamily
Length = 215
Score = 210 bits (535), Expect = 4e-54
Identities = 98/213 (46%), Positives = 141/213 (66%)
Query: 385 IGLIAYVPTNVXXXXXXXXXKSVGFSTFNVQLLSIPYQVIHIIFLLGITWFSERVKQRAY 444
+GL+AY+PTNV +S+GF+TF LL+IP V+HI+ L G+TW +E+ R
Sbjct: 1 MGLLAYIPTNVLATYLTLVLRSIGFTTFQANLLAIPNFVLHILLLFGLTWSTEKCNNRLG 60
Query: 445 MGIISAVWNAFFLAILRWWKGSLVEAWPTFALCTLLLGSPYVHAICVSWVSRNSNSIKTR 504
+ ++ ++ LA+LR+WKG++ W T+A+ TL+L +PY+HAICVS SRNS S+KTR
Sbjct: 61 LSLLQPLYTVPLLAVLRFWKGTMFNKWGTYAIITLILDNPYIHAICVSLCSRNSQSVKTR 120
Query: 505 ALSSALYNMAVQVGAIYSAQIYRENDKPLYHTGNTVLFSLAVVTTPIFLFVKWYYHKRNK 564
+S+ LYNM VQ G I S+ IY ++D PLY GN VLF LA+ PI + K Y NK
Sbjct: 121 TVSTCLYNMFVQAGLIISSNIYAKSDAPLYRKGNGVLFGLALFMFPILIGSKLIYVYINK 180
Query: 565 DKEAIWSKMSEDERIEYIHNTTDTANKRLDFRF 597
++ W+ MSE+E+ Y+ T+D ++RLDFRF
Sbjct: 181 QRDKRWNAMSEEEKDHYLSTTSDAGSRRLDFRF 213
>SPAC1039.04 [G] KOG2533 Permease of the major facilitator superfamily
Length = 507
Score = 153 bits (387), Expect = 6e-37
Identities = 116/445 (26%), Positives = 208/445 (46%), Gaps = 24/445 (5%)
Query: 128 EQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIFYISF 187
E+++ RK + R+ + L++ LD+ N+S A + + +DLG + YN+ IFYI F
Sbjct: 50 ERRLCRKFDFRILPLLALLYLFNALDKSNVSNAKTNGMDKDLGFVGDQYNIMISIFYIPF 109
Query: 188 LLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIGALEGGFIAD 247
+L P + KR G +P + S+ +++ QAA+ N G R +G E +
Sbjct: 110 VLCAFPFSYLYKRFGAARILPFFMLSFGAMSLCQAAVKNFGGMMAVRWFLGMAESAVLPG 169
Query: 248 LVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAGWQYLFLLEGI 307
+V +LT F+ E + RL+ F+ + ++ +LAYG+ ++G G L GWQYLFL+EG
Sbjct: 170 VVYYLTTFYRRTELARRLAIFYAAANVSSAFGGLLAYGVFHIKG-GKLQGWQYLFLIEGG 228
Query: 308 LTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDDPSKGDMHNRQPISF 367
+TF + +L++P +V+T N++ T+ E+ + R+ D S IS
Sbjct: 229 VTFLCAIV-IFLVLPVSVETANFL------TDEEKTLAKMRIENDSSS--------AISE 273
Query: 368 KLIWSAISDYDLWPIYFIGLIAY----VPTNVXXXXXXXXXKSVGFSTFNVQLLSIPYQV 423
KL + PI + L+ VP N ++GFS+ N L+++ +
Sbjct: 274 KLSFKQSLTVFKHPIAILWLLEEMALGVPLNSINNWLPQIVAAMGFSSVNTNLMTVAPAI 333
Query: 424 IHIIFLLGITWFSERVKQRAYMGIISAVWNAFFLAILRWWKGSLVEAWPTFALCTLLLGS 483
I+LL + S+ +K R + +I+A+ I+ + ++ C L+
Sbjct: 334 SGAIWLLVFAFISDFLKNRGIV-LIAAISTTMIGFIVYGSIDIMNHIGVSYFACFLMTAG 392
Query: 484 PYVHAICVS-WVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDKPLY--HTGNTV 540
++ S W + N+ + RA+ +++ V + SA I+R D P Y G T
Sbjct: 393 AAASSVLTSTWYNNNTPNESRRAVFTSVGVPLANVMGLVSANIFRPQDAPKYVPALGITA 452
Query: 541 LFSLAVVTTPIFLFVKWYYHKRNKD 565
F + + V ++ R +D
Sbjct: 453 GFGGLGILLVASISVYMFFDNRRRD 477
>SPAC1002.16c [G] KOG2533 Permease of the major facilitator superfamily
Length = 499
Score = 150 bits (378), Expect = 7e-36
Identities = 116/461 (25%), Positives = 218/461 (47%), Gaps = 30/461 (6%)
Query: 124 TKEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIF 183
TK E ++ +L++ +A L++ LDR N+ A V L EDL + + +N+ +F
Sbjct: 44 TKSERDSLLFRLDLVLAPTIMILYLVAFLDRSNIGNAKVAGLPEDLKLKGDQFNIIASVF 103
Query: 184 YISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIGALEGG 243
Y++F+L E+P+ L+ K++ P + + S+S+ + HN G R ++G E G
Sbjct: 104 YVTFILFEMPTTLLMKKVQPKRMLAFIVISYSLTTIFTGFCHNFGGLLAARLVLGFCEAG 163
Query: 244 FIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAGWQYLFL 303
L L+LT ++ E + R+++ + S +L + AY +L M G+GG AGW++LF+
Sbjct: 164 LFPCLALYLTMIYSRVELAPRIAYLFASSALSGAFGGLFAYAVLHMDGVGGFAGWRWLFI 223
Query: 304 LEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDDPSKGDMHNRQ 363
+EG++ F G+ Y ++P+ + TK W K E K + R + + D +
Sbjct: 224 IEGLIGFVCGV-AVYFIIPNDI-TKAWFLSK-THQEMMRKRQLERAADLEAAHFDWKGVK 280
Query: 364 P--ISFKLIWSAISDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKSVGFSTFNVQLLSIPY 421
FK+ A+S++ + G ++P + +G+++ +VQ ++IP
Sbjct: 281 SAFTDFKVYLYALSEFGQDTCLY-GFSTFLPAII---------SGMGYTSLSVQYMTIPV 330
Query: 422 QVIHIIFLLGITWFSERVKQRAYMGIISAVWNAF----FLAILRWWKGSLVEAWPTFALC 477
++ + ++ S+R R GII + N F ++ +L V + C
Sbjct: 331 YILGAATYIAASFLSDRFHHR---GIILIIGNIFPIVGYILLLACQNNKSV----LYFAC 383
Query: 478 TLLLGSPYVHA-ICVSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDKPLYHT 536
L Y A + V+W+S N RA + +L I + QIYR P Y
Sbjct: 384 YLCSVGVYTGAGLNVTWLSANIAPHYKRATAISLQLAIANSSGILAGQIYRY--PPKYIA 441
Query: 537 GN-TVLFSLAVVTTPIFLFVKWYYHKRNKDKEAIWSKMSED 576
G+ T L ++ + T + + + H+ +K ++++ S + D
Sbjct: 442 GHLTSLIAIFISTVLHVVNIFFLKHQNSKKQKSLASSSTID 482
>YGR260w [G] KOG2533 Permease of the major facilitator superfamily
Length = 534
Score = 137 bits (344), Expect = 6e-32
Identities = 116/487 (23%), Positives = 226/487 (45%), Gaps = 52/487 (10%)
Query: 128 EQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIFYISF 187
E++V+RK++I + + L+ LD+ N+ A V L +D+ + YN +F+ ++
Sbjct: 81 EKRVLRKMDIYLIPLMGMLYFLSNLDKSNIGNAEVAGLSKDIHLVGTQYNTCVTVFFATY 140
Query: 188 LLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIGALEGGFIAD 247
+L + + K +GP + + I + + +++ A + N + R L+GA EG
Sbjct: 141 VLFDPIGTNLLKIMGPPLMMSICLTCFGAISLGTAWVKNYAQLIVVRLLLGAFEGMIYPA 200
Query: 248 LVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAGWQYLFLLEGI 307
+ ++L+ + +++++R ++ +++ L ++AYG ++ G L WQY++++EG
Sbjct: 201 INMYLSVCYRREQYALRFAFVFSAACLSSSFGGLIAYGCSKIS--GSLKDWQYIYIVEGC 258
Query: 308 LTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDDPSKGDMHNRQPISF 367
++ +G FY S KN WF +EEK ++ + + + +
Sbjct: 259 IS--LGFVPFYAFGLS----KNL--EDSWFFNKEEKEYISERYK---TMNTFDPDEKFEW 307
Query: 368 KLIWSAISDYDLW---------PIYFIGLIAYVPTNVXXXXXXXXXKSVGFSTFNVQLLS 418
+W A+ D W + GL ++P + S+GF+ QL++
Sbjct: 308 FQVWQAVKDVKTWASAVALFGIDLTTFGLTVFLPIIIT---------SMGFTNVRAQLMT 358
Query: 419 IP-YQVIHIIFLLGITWFSERVKQRAYMGIISAVWNAFFLAILRWWKGSLVEAWPTFALC 477
+P Y + I+F + W S+R+K R+ + + + + +AI+ GS V F +
Sbjct: 359 VPIYFLTAIVFFICAVW-SDRIKLRSPFILGACLTTSIGIAIV---LGSQVHGVRYFGVY 414
Query: 478 TLLLGSPYVHAIC-VSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDKPLYHT 536
L +G YV+A C W+S N+ + RA + + + S QI+ DKP Y
Sbjct: 415 ILCMGI-YVNAACNCLWLSGNTGNYFKRATALGINLFFGSGSGLVSGQIFVAKDKPRYIK 473
Query: 537 GNTV-----LFSLAVVTTPIFLFVKWYYHKRNKDKEAIWSKMSE-DERIEYIHNTTDTAN 590
G ++ +FS+ + IFL Y + N K+AI + +E E I Y +D
Sbjct: 474 GLSISLAFQVFSIFMTVVQIFL-----YKRENDKKKAIIDRCNELGEPIPYDERLSD--- 525
Query: 591 KRLDFRF 597
K +F++
Sbjct: 526 KNPEFKY 532
>SPAC11D3.18c [G] KOG2533 Permease of the major facilitator superfamily
Length = 498
Score = 136 bits (342), Expect = 1e-31
Identities = 108/450 (24%), Positives = 197/450 (43%), Gaps = 37/450 (8%)
Query: 128 EQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIFYISF 187
E+K++ K+++ ++ + +L++ LDR N+ A V + E L + N+ IFY+ +
Sbjct: 50 EKKLLLKMDLVISPIIGFLYLMAFLDRSNIGNAAVAGMTEALSLYGERLNVAVSIFYVLY 109
Query: 188 LLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIGALEGGFIAD 247
+L E PS ++ KR+ + +WS+ + M + G R ++G LEG
Sbjct: 110 ILVETPSVVLVKRIKASRMLAFISFAWSMTVLFSGFMSSYGGLIATRLILGLLEGCLFPA 169
Query: 248 LVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAGWQYLFLLEGI 307
L L+LT +T KE RLS+ + S L + AY + ++ G GWQ+++++EG+
Sbjct: 170 LNLYLTTHYTRKEQCQRLSYLFASAGLAGAFGGLFAYALEQVHA-GNKEGWQWIYIVEGL 228
Query: 308 LTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDDPSKGDMHNRQPISF 367
++ FIG+ +P ++ WF REE+ V ++R D H Q +
Sbjct: 229 VS-FIGVPLCLFALPDKME-------NAWFLTREEREVA--IIRRD-INARYHGEQHFEW 277
Query: 368 KLIWSAISDYDLW---------PIYFIGLIAYVPTNVXXXXXXXXXKSVGFSTFNVQLLS 418
+ A D ++ + G +++P + K +GF ++
Sbjct: 278 SEVRKAFKDPKVYVSATSQFCADMVLYGFSSFLPVII---------KGLGFVGLQTNYMT 328
Query: 419 IPYQVIHIIFLLGITWFSERVKQRA-YMGIISAVWNAFFLAILRWWKGSLVEAWPTFALC 477
IP + +I L + W S+R + RA Y+ S V ++ +L S A A
Sbjct: 329 IPVYIAGVISFLFVAWLSDRTQLRAVYLISASTVVAVGYIIML----ASDSNAAKYTATY 384
Query: 478 TLLLGSPYVHAICVSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDKPLYHTG 537
+ +G + + W++ N RA + + I + QIYR + P Y G
Sbjct: 385 IIAIGCYIGPGLNLGWLNNNVAGHYKRATAIGIQQTLANSSGIVAGQIYRSKNAPKYILG 444
Query: 538 NTVLFSLAVVTTPIFLFVKWYYHKRNKDKE 567
N F+L V +V ++ R +K+
Sbjct: 445 NA--FTLGCVIVGGLAYVVMFFSLRYVNKK 472
>SPCC417.10 [G] KOG2533 Permease of the major facilitator superfamily
Length = 508
Score = 131 bits (329), Expect = 3e-30
Identities = 125/531 (23%), Positives = 222/531 (41%), Gaps = 46/531 (8%)
Query: 86 SLTSDNPFSDPKIAEYYRALYDDSKYESRSAFDPEFTWT---------KEEEQKVVRKLN 136
S++ D DP+ + L D S D F + E E+++VRK++
Sbjct: 3 SISIDEKLKDPESVQNKEILDVDVGDLSPKGVDAAFNYALDVDYDEIDPETERRLVRKID 62
Query: 137 IRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIFYISFLLAEIPSQL 196
+ V C ++ LD+ + S AV+ L EDL M Y+ FY+ +L+ E P+ L
Sbjct: 63 CTIFPVMCLVYCIQFLDKTSNSYAVIMGLKEDLKMEGQMYSWSGTAFYLGYLVFEFPASL 122
Query: 197 ISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIGALEGGFIADLVLWLTYFF 256
+ +R + + + W + + ++ N GF R L+G +E +L ++
Sbjct: 123 LLQRFPLSKTLCVFLVIWGFL-LCMTSVANYPGFIALRVLLGMMESAASPGFILLTAQWY 181
Query: 257 TSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAGWQYLFLLEGILTFFIGLTG 316
E +R S + L QIL + +AYG+ + + + GW+ +F++ G+L F+G
Sbjct: 182 KRSEQQLRTSVWVAFNGLGQILGSCMAYGLAKRTSL-PMRGWKLIFIICGVLAIFLG--- 237
Query: 317 FYLMVPSAVQTKNWMHPKGWF-TEREEKIVVNRVLRDDPSKGDMHNRQPISFKL--IWSA 373
V AV N K WF TE + K+VV R+ + G+ H FKL
Sbjct: 238 ---FVILAVVPDNPF--KAWFLTEEDRKLVVKRLRANKQGVGNNH------FKLYQFKET 286
Query: 374 ISDYDLWPIYFIGLIAYVPTNVXXXXXXXXXK-SVGFSTFNVQLLSIPYQVIHIIFLLGI 432
+ D W ++ ++ +P K ++G+ T L+ +P L+
Sbjct: 287 MLDIRTWIMFVSSVLLNIPNGGIGTFSSLLIKGTMGYDTLQTLLMGLPAGACEFGGLIAF 346
Query: 433 TWFSERVKQRAYMGIISAVWNAFFLAILRWWKGSLVEAWPTFALCT---LLLGSPYVHAI 489
+ S + +R + I+ +L + A P A LL+ SP +
Sbjct: 347 GFLSLFIHKRMVLATITTCIALIGSCLLSF-------AGPPRAQLAGYYLLMVSPGAMIV 399
Query: 490 CVSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDKPLYHTGNTVL---FSLAV 546
+ +S N++ + +Y + VG + Q ++ D P Y + ++ +
Sbjct: 400 MFAIISSNASGYTKKVTVGVIYLIGYCVGNLIGPQTFKAADAPEYMPAKNTMVGCYAATL 459
Query: 547 VTTPIFLFVKWYYHKRNKDKEAIWSKMSEDERIEYIHNTTDTANKRLDFRF 597
VT P +V W +KR +D+ A K+ E+ + TD N LDFR+
Sbjct: 460 VTFPALYYVNWRENKR-RDQLAAEGKIEHRPNAEF-EDLTDFEN--LDFRY 506
>SPBC1683.12 [G] KOG2533 Permease of the major facilitator superfamily
Length = 482
Score = 129 bits (324), Expect = 1e-29
Identities = 112/469 (23%), Positives = 202/469 (42%), Gaps = 19/469 (4%)
Query: 113 SRSAFDPEFTWTKEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMN 172
S FD + T K+EE K+VRKL+ + + L+ LDR N+ A V L EDL +
Sbjct: 19 SEGTFD-DITIEKKEEAKLVRKLDWYLMPMFSVLYFLSFLDRANIGNAAVVGLKEDLKLQ 77
Query: 173 RNDYNLGNQIFYISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFI 232
Y+ +FY +++ AE PS L+ K+ GP ++ I WS+V + + + +
Sbjct: 78 AYQYSAAVSVFYATYITAETPSVLLVKKFGPHYYLSAMIIGWSLVTIFTCFVRHYWSLVL 137
Query: 233 CRCLIGALEGGFIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGI 292
R L+G EGGF L L+++ + +E RL++ + ++A G+ ++
Sbjct: 138 TRLLLGICEGGFFPCLSLYISMTYKREEQGKRLAYLYVCSCFSGAFGGLIATGLTKIPKS 197
Query: 293 GGLAGWQYLFLLEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRD 352
GL W +L+++EG+++ L + + P T +++P RE++++ R +
Sbjct: 198 SGLPNWGWLYIIEGLISAISALWILFCL-PDDPSTARFLNP------REKELMKIRAEQR 250
Query: 353 DPSKGDMHNRQPISFKLIWSAISDYDLWPIYFI-GLIAYVPTNVXXXXXXXXXKSVGFST 411
G N F+ + Y I F L+ Y + +G+S+
Sbjct: 251 QKYMGS-PNFDWTQFRKAFKDPKMYMSCVIQFCQDLVLY---GISTFLPSILKLELGYSS 306
Query: 412 FNVQLLSIPYQVIHIIFLLGITWFSERVKQRAYMGIISAVWNAFFLAILRWWKGSLVEAW 471
Q +S+P + I + I S+R R + I + IL S
Sbjct: 307 LAAQYMSVPVYALGGISVYVICLLSDRTNIRGWFIIGMNFFGLAGFIILLATTNSAANYV 366
Query: 472 PTFALCTLLLGSPYVHAICVSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDK 531
T+ + L P V A+ ++W++ N RA + + + + Q+YR +
Sbjct: 367 ATYLIALPLY--PTV-ALNITWINNNMAPHYRRATALGCNQTIGNLAGVIAGQVYRSSP- 422
Query: 532 PLYHTGNTVLFSLAVVTTPIFLFVKWYYHKRNKDKEAIWSKMSEDERIE 580
Y G+ VV T +++Y ++NK K+ I + DE+ E
Sbjct: 423 --YKLGHGFALGCTVVGTLTATAMRFYLQRQNKIKQEILNGERVDEKKE 469
>SPCC757.13 [G] KOG2533 Permease of the major facilitator superfamily
Length = 522
Score = 118 bits (296), Expect = 2e-26
Identities = 110/494 (22%), Positives = 225/494 (45%), Gaps = 41/494 (8%)
Query: 118 DPEFTWTKEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYN 177
D +FT+T +E ++V+ K+++ + V C ++ LD+ LS A + + D ++ + Y+
Sbjct: 56 DDDFTYTAKEARRVLWKIDLVMMPVMCITYMIQYLDKTALSYAALYGMKTDTHIDGHTYS 115
Query: 178 LGNQIFYISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLI 237
+FY +L+A+ P+ ++ ++ FI + WS + AA N R L
Sbjct: 116 SMTTLFYAGYLVAQYPAAILMQKCRLSYFIFCNVFLWSAMVCLMAACRNGPSLLGLRFLA 175
Query: 238 GALEGGFIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAG 297
G E + ++ +E +R ++ + QI+ +IL+YG+ + G +A
Sbjct: 176 GIFEASITPAFINITAMWYRREEQPMRTLCWYAFNGIAQIIGSILSYGLGHIH--GKVAS 233
Query: 298 WQYLFLLEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDDPSKG 357
W+Y+F++ G+++ G+ ++ +PS ++ + RE++I + RV RD ++
Sbjct: 234 WRYVFIVIGLMSLGWGVV--FVFIPSNPSKARFL------SSREKRIALERV-RD--NRT 282
Query: 358 DMHNRQPISFKLIWSAISDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKSVGFSTFNVQLL 417
+ N+Q +K + A D + I + + TN K +G++ + +L
Sbjct: 283 GLENKQ-FKWKHAYEAFLDPQVIMITLFTGVCMI-TNGIGVFSTLIIKGLGYNELHSAVL 340
Query: 418 SIPYQVIHI--IFLLGITWFSERVKQRAYMGIISAVWNAFFLA-ILRWWK-------GSL 467
++P I + +F+ G+ +V + + +I N LA L WK G L
Sbjct: 341 NMPLGAIEVAAMFISGVLC---KVFKNGRL-LIGVFMNCLTLAGCLMIWKIPDSNPYGRL 396
Query: 468 VEAWPTFALCTLLLGSPYVHAICVSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYR 527
V W T + P A+ +S +S N + ++SA + VG I S Q+++
Sbjct: 397 VGVWFT-------MWVPASSALLLSLISSNVAGYTKKTVTSATVFVFYSVGNIVSPQLFK 449
Query: 528 ENDKPLYHTG-NTVLFSLAVVTTPIFLFVKWYYHKRNKDKEAIWSK---MSEDERIEYIH 583
P Y G ++ SL ++ F+ +Y ++ NK ++ + ++ + E + E
Sbjct: 450 SGQTPEYIEGIQAMIVSLCIIIAIAFVLTGYYIYE-NKRRDRLLAEDPSLGESIKNEEFM 508
Query: 584 NTTDTANKRLDFRF 597
+ TD + +R+
Sbjct: 509 DLTDRQQPKFRYRW 522
>SPCPB1C11.03 [G] KOG2533 Permease of the major facilitator superfamily
Length = 570
Score = 115 bits (289), Expect = 1e-25
Identities = 120/553 (21%), Positives = 226/553 (40%), Gaps = 45/553 (8%)
Query: 60 SDKRRAEVDVKRVSISSFDVEIRSQD-SLTSDNPF-SDPKIAEYYRALYDDSKYESRSAF 117
S K E+ SS D+E + T PF SD IA+ +A K + S
Sbjct: 14 SSKEGYEIRQGSTDSSSLDLEKKENAVDTTIAKPFDSDEDIADVEKA---GGKKINNSLI 70
Query: 118 DPEFTW----------TKEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLE 167
D F + T ++E K+ KL I + L+ +L + L + + LS + + L +
Sbjct: 71 DETFAFMQDAKKLDPLTPKQESKLKWKLYIYLLLMLGFLDMMLFIGKATLSYSTILGLFD 130
Query: 168 DLGMNRNDYNLGNQIFYISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNK 227
D+ + N YN N +FY+ +++ + P I + F+ + SWSV+ +N
Sbjct: 131 DVHITSNQYNNLNTLFYVGYIVGQFPGHYIMQTFPLGKFVGLVTFSWSVIVFLHCCAYNY 190
Query: 228 TGFFICRCLIGALEGGFIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGIL 287
G R +G E + + + FFT +E + FW S I + +AYG+
Sbjct: 191 GGLIALRFFLGFTESCLLPAMEATMGMFFTHQEQAFLQPVFWISCLSCGIPAGFIAYGLE 250
Query: 288 RMRGIGGLAGWQYLFLLEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVN 347
+ +A W+ ++ G +TFF+ + F+ + + + + T+ E+ ++
Sbjct: 251 FV--TKSIAPWKLFMIITGGITFFLSIFLFFYYPDNPSKAR-------FLTDEEKLYTID 301
Query: 348 RVLRDDPSKGDMHNRQPISFKLIWSAISDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKSV 407
RV + ++G + N+ + I A+ D W F + N+ S+
Sbjct: 302 RVRKS--TRGGIENKIFKKHQFI-EALKDPITWLFTFAAFTLMLSNNLAYQQNLIFT-SL 357
Query: 408 GFSTFNVQLLSIPYQVIHIIFLLGITWFSERV-KQRAYMGII----SAVWNAFFLAILRW 462
S N L+ + + + + T+ + Q AY + S F+A+
Sbjct: 358 NVSDLNSTLVGVALAGYNTVSAIIATFAMYLIPNQSAYHAMFWMLPSITGGIAFVALP-- 415
Query: 463 WKGSLVEAWPTFALCTLLLGSPY--VHAICVSWVSRNSNSIKTRALSSALYNMAVQVGAI 520
W + E L T+++ S + + I + W + S + ++ + + I
Sbjct: 416 WSNRIGE------LATMIIASDFGITYIIALGWTTATSTGYTKKLTRGLMFMVGYAIANI 469
Query: 521 YSAQIYRENDKPLYHTGNTVLFSLAVVTTP-IFLFVKWYYHKRNKDKEAIWSKMSEDERI 579
S Q+++ D P Y+ V +A TP I+L + +RNK ++ + K + +
Sbjct: 470 ISPQLWQSRDAPRYYPAWIVQIVVAWFVTPIIYLVARVILARRNKQRKELKDKKIAEGSL 529
Query: 580 EYIHNT-TDTANK 591
E I T DT ++
Sbjct: 530 ETIEKTYVDTVDE 542
>SPBPB10D8.01 [G] KOG2533 Permease of the major facilitator superfamily
Length = 552
Score = 114 bits (285), Expect = 4e-25
Identities = 96/474 (20%), Positives = 200/474 (41%), Gaps = 27/474 (5%)
Query: 124 TKEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIF 183
T ++++++ KL V ++ L + L +D+ LS + + L ED +N N YN N +F
Sbjct: 74 TPKQDKRLRWKLYFTVLVMLMILDMMLYIDKATLSYSSILGLFEDTHINSNQYNDINTLF 133
Query: 184 YISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIGALEGG 243
Y+ F++ +IP ++ +R F+ W+++ A +N +G R +G +E
Sbjct: 134 YVGFVIGQIPGHMLLQRFPVSKFVAASTALWTIIIFLHCAAYNFSGLMALRFFLGLVESS 193
Query: 244 FIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAGWQYLFL 303
+ + + FF E ++ +F+ S I + +AYG+ + ++ W+ +
Sbjct: 194 LLPTMEATIGMFFPHSEQALLQPFFYISCYGCNIPAGFIAYGVQYAKNT--ISPWKLFMI 251
Query: 304 LEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDDPSKGDMHNRQ 363
+ G +TFF+ + G + P T ++ T++E V+RV R + S + ++
Sbjct: 252 IVGGITFFLTI-GLFFYYPDNTSTARFL------TKKERLYTVDRVRRSNHS--GIESKT 302
Query: 364 PISFKLIWSAISDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKSVGFSTFNVQLLSIPYQV 423
+++I A+ D W F + N+ S+ S N L+ +
Sbjct: 303 FKKYQVI-EALKDPVTWLFTFHVFCNQLSNNLAYQQNLLFT-SLNVSDLNSTLVGVASAG 360
Query: 424 IHIIFLLGITWFSERVK-QRAYMGIISAVWNAFFLA-----ILRWWKGSLVEAWPTFALC 477
+ + + T+ +K Q A+ G A+W +A + W + E +
Sbjct: 361 YNCVSAIIATYMMSVIKNQSAFHG---AIWYIPSIAGGIACVAMSWDHKIGEL--AAIII 415
Query: 478 TLLLGSPYVHAICVSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDKPLYHTG 537
G P++ I + W + + + ++ + + I Q+++ D P Y+
Sbjct: 416 ASNFGIPFI--ISLGWTTASCAGYTKKLTRGVMFMIGYAIANIIGPQMWQSRDAPRYYPA 473
Query: 538 NTVLFSLAVVTTP-IFLFVKWYYHKRNKDKEAIWSKMSEDERIEYIHNTTDTAN 590
V +A +P + L ++W +RNK + A+ + E +I + N
Sbjct: 474 WIVQIVIAWSVSPFVLLIIRWILVRRNKKRLALLEQNKEQYEKTWIETIDSSGN 527
>YLL055w [G] KOG2533 Permease of the major facilitator superfamily
Length = 531
Score = 113 bits (282), Expect = 9e-25
Identities = 104/498 (20%), Positives = 203/498 (39%), Gaps = 27/498 (5%)
Query: 74 ISSFDVEIRSQDSLTSDNPFSDPKIAEYYRALYDDSKYESRSAFDPEFTWTKEEEQKVVR 133
+S DV+I + +SD ++A+ A +++ A PE T E+E+K+ R
Sbjct: 1 MSKVDVKIGADSISSSDEILVPSRLADVTLAFMEEN-----DAAVPEIT--PEQEKKLKR 53
Query: 134 KLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIFYISFLLAEIP 193
KL + + + + L +D+ LS + ED G+ +N YN N +FY+ F + + P
Sbjct: 54 KLFLTIFTFVSAINLLLYMDKATLSYDSILGFFEDTGLTQNTYNTVNTLFYVGFAIGQFP 113
Query: 194 SQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIGALEGGFIADLVLWLT 253
Q ++++L F+ + +W+++ +N +G R +G E I L+ +
Sbjct: 114 GQYLAQKLPLGKFLGGLLATWTILIFLSCTAYNFSGVVALRFFLGLTESVVIPILITTMG 173
Query: 254 YFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAGWQYLFLLEGILTFFIG 313
FF + E + +F+ + I + +AYG+L + ++ W+ ++ G LTF +
Sbjct: 174 MFFDASERAAAQPFFFAACMGSPIPTGFIAYGVLHITN-PSISLWKIFTIIIGGLTFIMT 232
Query: 314 LTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDDPSKGDMHNRQPISFKLIWSA 373
+ + K +F+ +E ++ RV S G ++ A
Sbjct: 233 VVVILWFPNNPADVK-------FFSIQERVWIIRRV---QASTGSSIEQKVFKKSQFREA 282
Query: 374 ISDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKSVGFSTFNVQLLSIPYQVIHIIFLLGIT 433
+ DY W L+ + N+ G L+S+ ++ T
Sbjct: 283 MKDYITWLFGLFFLLQQLANNLPYQQNLLFEGMGGVDALGSTLVSVAGAGFAVVCAFIAT 342
Query: 434 WFSERVKQ----RAYMGIISAVWNAFFLAILRWWKGSLVEAWPTFALCTLLLGSPYVHAI 489
+ K A + A+ + A L W + + + + G P++ I
Sbjct: 343 LMLAKWKNISALTAIFWTLPALVGSIAAAALPW--DNKIGILANICMAGQIFGIPFI--I 398
Query: 490 CVSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDKPLYHTGNTVLFSLAVVTT 549
+SW S +++ + S++ A+ + I S QI+RE D P + V L+
Sbjct: 399 ALSWASSSASGYTKKLTRSSVSLFAMGIANIISPQIWREKDSPRFLPAWIVQIVLSFSLA 458
Query: 550 P-IFLFVKWYYHKRNKDK 566
P I L + + +RN +
Sbjct: 459 PAILLLIHFILKRRNNQR 476
>YAL067c [G] KOG2533 Permease of the major facilitator superfamily
Length = 593
Score = 108 bits (271), Expect = 2e-23
Identities = 117/525 (22%), Positives = 233/525 (44%), Gaps = 43/525 (8%)
Query: 65 AEVDVKRVSISSFDVEIRSQDSLTSDNPFSDPKIAEYYRALYDDSKY---ESRSAFDPEF 121
+E D SS+ E + ++T + D ++R +D+ +Y E + + +
Sbjct: 60 SEKDQLHFETSSYS-EHKDNVNVTRSYEYRDEADRPWWR-FFDEQEYRINEKERSHNKWY 117
Query: 122 TWTKE----EEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRND-- 175
+W K+ +E+K++ KL++ +A +C + LD N++ A V + EDLG ND
Sbjct: 118 SWFKQGTSFKEKKLLIKLDVLLAFYSCIAYWVKYLDTVNINNAYVSGMKEDLGFQGNDLV 177
Query: 176 -----YNLGNQIFYISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGF 230
Y +GN IF + FL + +L + +P WS++ + A +++
Sbjct: 178 HTQVMYTVGNIIFQLPFL-------IYLNKLPLNYVLPSLDLCWSLLTVGAAYVNSVPHL 230
Query: 231 FICRCLIGALEG-GFIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSA--ILAYGIL 287
R IGA E ++A L+ +++ + +R S F+ + ILSA I +
Sbjct: 231 KAIRFFIGAFEAPSYLAYQYLFGSFY--KHDEMVRRSAFYYLGQYIGILSAGGIQSAVYS 288
Query: 288 RMRGIGGLAGWQYLFLLEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVN 347
+ G+ GL GW++ F+++ I++ +GL GFY + + + T+ E ++
Sbjct: 289 SLNGVNGLEGWRWNFIIDAIVSVVVGLIGFYSLPGDPYNCYSI-----FLTDDEIRLARK 343
Query: 348 RVLRDDPSKGDMHNRQPISFKLIWSAISDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKSV 407
R+ + K D + KL + SD+ ++ + + + +NV KS+
Sbjct: 344 RLKENQTGKSDFETK-VFDIKLWKTIFSDWKIYILTLWNIFCWNDSNVSSGAYLLWLKSL 402
Query: 408 -GFSTFNVQLLSIPYQVIHIIFLLGITWFSERVKQRAYMGIISAVWNAFFLAILRWWKGS 466
+S + LS+ + +++L+ ++++ R + I + V+N +IL W +
Sbjct: 403 KRYSIPKLNQLSMITPGLGMVYLMLTGIIADKLHSRWFAIIFTQVFNIIGNSILAAWDVA 462
Query: 467 LVEAWPTFAL-CTLLLGSPYVHAICVSWVSR-NSNSIKTRALSSALYNMAVQVGAIY-SA 523
W F L C +P ++ SW + +TRA++ N+ Q + S
Sbjct: 463 EGAKWFAFMLQCFGWAMAPVLY----SWQNDICRRDAQTRAITLVTMNIMAQSSTAWISV 518
Query: 524 QIYRENDKPLYHTGNTVLFSLAVVTTPIFLFVKWYYHKRNKDKEA 568
+++ + P Y G T + + I+ FV Y++KR++ A
Sbjct: 519 LVWKTEEAPRYLKGFT-FTACSAFCLSIWTFVVLYFYKRDERNNA 562
>YLR004c [G] KOG2533 Permease of the major facilitator superfamily
Length = 523
Score = 105 bits (261), Expect = 3e-22
Identities = 125/554 (22%), Positives = 221/554 (39%), Gaps = 57/554 (10%)
Query: 59 DSDKRRAEVDVKRVSISSFDVEIRSQDSLTSDNPFSDPKIAEYYRALYDDSKYESRSAFD 118
D +K+ A D VS SS +V+ D+ + + E A DD + +
Sbjct: 10 DVEKKAANADSCSVSTSSINVD----DADVALRFLKQNGLDESSTANEDDVV----AGEE 61
Query: 119 PEFTWTKEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNL 178
F + E KV+RK+++ + C ++ + LD+ L+ A + + L N NL
Sbjct: 62 ANFYGSHELSPKVLRKVDLFILPFLCCTYLLMFLDKALLNYAASMGIKDHLKGNEFS-NL 120
Query: 179 GNQIFYISFLLAE------IPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFI 232
G IF +++ E I ISK LG I + W +V AA +
Sbjct: 121 GT-IFSAAYIFMEPVVTYLIQKFPISKILGTFITV------WGIVLACHAACKTYASLMV 173
Query: 233 CRCLIGALEGGFIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGI 292
R L+G E + ++T E S R+ ++ T I+ ++++G L G
Sbjct: 174 VRTLLGLFESSSAVGCIAISGMYYTKSEQSARIGFWATQAGTGYIVGGLISFGFLHYHGT 233
Query: 293 GGLAGWQYLFLLEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRD 352
WQ +FL+ G++T G+ F L +P V WF +EEKI V +R
Sbjct: 234 -AFTSWQIMFLVVGLVTVAFGVLTF-LYLPDNV-------TNAWFLNKEEKIQVVEHIRA 284
Query: 353 DPSKGDMHNRQPISFKLIWSAISDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKSVGFSTF 412
+ + + + K ++ + D WP+ + + + T + GF +
Sbjct: 285 NQTGLETKKFKKQQVKELF--LHDKFTWPMLLLTACSQISTGAIGTFSVTITGTFGFDKY 342
Query: 413 NVQLLSIPYQVIHIIFLLGITWFSERVKQRAYMGIISAVWNAFFLAILRWWKGSLV---- 468
LL +P I + +L T R G I+ + + ++ + G +V
Sbjct: 343 ETALLQLPIGAITAMIILITTQMLSR------WGHITLITTSMYIPAI---IGCIVLISL 393
Query: 469 ----EAWPTFALCTLLLGSPYVHAICVSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQ 524
+ F+L L GS + I + W S N++ R +A+ + V I + Q
Sbjct: 394 PLSHKIGNLFSLYLLYSGSCVITNIYI-WNSCNTSGYTKRVFRNAITMIVYNVSCIIAPQ 452
Query: 525 IYRENDKPLYHTGNTVLFSLAVVTTPIFLFVKWYYHKRNKDKEAIWSKMSEDERIEY-IH 583
++R P Y L V P+ L++ + K N+ ++ + ER +Y
Sbjct: 453 MFRAYSAPRYIPAKIALLVTQCVCVPLQLYIGYICKKENEKRD---KEQEGQERKKYQFL 509
Query: 584 NTTDTANKRLDFRF 597
+ TD N+ +FR+
Sbjct: 510 DLTDIENR--NFRY 521
>YJR152w [G] KOG2533 Permease of the major facilitator superfamily
Length = 543
Score = 97.8 bits (242), Expect = 4e-20
Identities = 123/556 (22%), Positives = 230/556 (41%), Gaps = 38/556 (6%)
Query: 60 SDKRRAEVDVKRVSISSFDVEIRSQDSLTSDNPFSDPKIAEYYRALYDDSKYESRSAFDP 119
S A +D K ++I+S + EI+++D + P ++ + +Y K +
Sbjct: 6 STNSNASLDEKNLNITS-EAEIKNED--VTAEPVLSTVLSPNGKIVYISDKVDEAMKLAE 62
Query: 120 E---FTWTKEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDY 176
E T EE++K+ K++ + + C L+ +D+ + S A V L DL M+ + Y
Sbjct: 63 EAKEIEVTPEEDRKLRWKIDYCMFPLMCILYAVQFMDKISTSSAAVMGLRTDLKMHGDQY 122
Query: 177 NLGNQIFYISFLLAEI-PSQLISKRLGP-DIFIPIQICSWSVVAMAQAAMHNK-TGFFIC 233
+ FY +L + P Q I +R + + I W ++ AA K F +
Sbjct: 123 SWVTSAFYFGYLFMNLGPVQFIFQRTSHMSKMLAVFIVIWGMLLALHAAPTVKYPSFIVL 182
Query: 234 RCLIGALEGGFIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIG 293
R L+G E + ++ ++E R+S ++ L IL +AYG+ +
Sbjct: 183 RVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGLGSILINAIAYGVYIHQDSY 242
Query: 294 GLAGWQYLFLLEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDD 353
+ GW+ LF++ G++T FIG+ +L +P ++ ++RE+ +VV R+ +
Sbjct: 243 AIKGWRTLFVITGVITIFIGIL-IFLWIPDDPSKARFL------SKREKLMVVQRIRSNQ 295
Query: 354 PSKGDMHNRQPISFKLIWSAISDYDLWPIYFIGLIAYVPT-NVXXXXXXXXXKSVGFSTF 412
G N + +++I A+ D W + + + +P + G+S+
Sbjct: 296 QGFG---NHEIKKYQII-EALKDVRTWLYFLFTVSSNIPNGGISSFMSILLNSDFGYSSK 351
Query: 413 NVQLLSIPYQVIHIIF--LLGITWFSERVKQRAYMGIISAVWNAFFLAILRWWKGSLVEA 470
L+ +P + ++ L GI K+ + W A F A+L S +
Sbjct: 352 ETLLMGLPTGAVELVGCPLFGILAVYAANKKIPFWK-YKLSW-AIFAAVLA-LIASCMLG 408
Query: 471 WPTFALCTLLLG------SPYVHAICVSWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQ 524
+ T + L G SP +S +S NS+ + S++ +A + Q
Sbjct: 409 FATNSKKARLAGAYLWYISPVSFICVLSNISANSSGYSKKWTVSSINLVAYAAANLAGPQ 468
Query: 525 IYRENDKPLYH---TGNTVLFSLAVVTTPIFLFVKWYYHKRNKDKEAIWSKMSEDERIEY 581
+ P YH V +++ +V I L V +KR A E E +E+
Sbjct: 469 TFIAKQAPKYHGAKVAMVVCYAVMIVLLSILLIVNLRENKRRDKIAAERGFPEETENLEF 528
Query: 582 IHNTTDTANKRLDFRF 597
+ TD N +FR+
Sbjct: 529 -SDLTDFENP--NFRY 541
>SPBC1773.15 [G] KOG2533 Permease of the major facilitator superfamily
Length = 497
Score = 96.7 bits (239), Expect = 9e-20
Identities = 96/475 (20%), Positives = 192/475 (40%), Gaps = 36/475 (7%)
Query: 125 KEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIFY 184
K +K+ K ++ V + C + +D+ + + + + DL M N YN FY
Sbjct: 38 KSLNRKLKLKTDLWVMPLLCLISAFQYMDKSTSNYSSIMGIRTDLNMVGNQYNWVGTSFY 97
Query: 185 ISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIGALEGGF 244
+ F++ +P + ++ I +W ++ +H+ + R L+G LE
Sbjct: 98 LGFMVFSLPLSTLLQKFPLSKVTSAFIVAWGILMTLTCLVHSYASYIATRTLLGILESVI 157
Query: 245 IADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGL--AGWQYLF 302
VL++ ++ +E R+++ L ++ ++YG+ + L + W+ LF
Sbjct: 158 TPAFVLFIAQWYRKEEQFFRMAFLVAWNGLGGLIGGSMSYGLYKRELENNLTMSPWRILF 217
Query: 303 LLEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWF-TEREEKIVVNRVLRDDPSKGDMHN 361
++ G++T G+ ++ +P K WF +E+E+ +V+ R+ D G
Sbjct: 218 IITGLITIINGVF-IFIHIPDEPS-------KAWFLSEKEKDLVLKRLDTDHAGLGSKKF 269
Query: 362 RQPISFKLIWSAISDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKSVGFSTFNVQLLSIPY 421
++ I A D ++ +F+ + +P K++G+ L+++P
Sbjct: 270 KK----YQILEACRDVRMYLYFFLQIAVAIPNGGLSNFSSIMLKNLGYVKGKALLMNMPT 325
Query: 422 QVIHI--IFLLG-ITWFSERVKQRAYMGIISAVWNAFFLAILRWWKGSLVEAWPTFALCT 478
I + L G I F+ R A +G+ + + +A + L W
Sbjct: 326 SSISFAALTLFGLIPEFTNRRMDIALVGLAINLTSGSLIAFAKPTHAQLAGYW------- 378
Query: 479 LLLGSPYVHAICV-SWVSRNSNSIKTRALSSALYNMAVQVGAIYSAQIYRENDKPLYHTG 537
L G + IC+ S +S NS + SA+ + VG + Q +R P Y G
Sbjct: 379 -LFGISPIPYICILSCISSNSAGHTKKVFMSAVSMIGYCVGNMVGPQTFRSTQAPKYQ-G 436
Query: 538 NTVLFSLAVVTTPIFLFVKWYYHKRNKDKEAIWSKMSEDERIEYIHNTTDTANKR 592
V F + IF+ + Y +++ DE+ EY+ N +K+
Sbjct: 437 AKVSF-VVCYCVAIFIIIAIYAVNVRENRR-------RDEKNEYLSNELSEEDKK 483
>YGR065c [G] KOG2533 Permease of the major facilitator superfamily
Length = 593
Score = 87.8 bits (216), Expect = 4e-17
Identities = 93/460 (20%), Positives = 194/460 (41%), Gaps = 20/460 (4%)
Query: 119 PEFTWTKEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNL 178
P T + E++++ KL+I +AL L + +D N + A V N+ EDL M NDY
Sbjct: 109 PNHTTQTKAERRLLYKLDIIIALYFFMLCWSKSVDLNNYTNAYVSNMKEDLNMKGNDYVY 168
Query: 179 GNQIFYISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCLIG 238
+ I + ++ ++P + R I +P+ W+ A ++ R ++
Sbjct: 169 TSTIANVGAIVFQLPFMYLLPRFPSHIILPVMDLGWTWFTFACYRANSLAELRAYRFILS 228
Query: 239 ALEGGFIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILR-MRGIGGLAG 297
A + L ++ E + R+ F+ L + S +L I + + G+ GLAG
Sbjct: 229 AFGAAYYPVSQYILGCWYAPDEINSRVCLFFCGQQLGSVTSGLLQSRIFKSLNGVHGLAG 288
Query: 298 WQYLFLLEGI-LTFFIGLTGFYLM--VPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDDP 354
W+++FL++ I ++ + GF+++ VPS + + T+ E +I R R+
Sbjct: 289 WRWMFLIDAIAISLPTAIIGFFVIPGVPSKCYSL-------FLTDEEIRIARARNKRNQI 341
Query: 355 SKG-DMHNRQPISFKLIWSAI-SDYDLWPIYFIGLIAYVPTNVXXXXXXXXXKS-VGFST 411
G D P+ + +W + W + ++ KS +S
Sbjct: 342 KDGVDKSKLAPLWSRKLWKKVFCTPAFWVLVVFDTCSWNNMTAYSGSYTLWLKSNTKYSI 401
Query: 412 FNVQLLSIPYQVIHIIFLLGITWFSERVKQRAYMGIISAVWNAFFLAIL-RWWKGSLVEA 470
V LS+ + +++ + ++ + + + +A+ N A+L +W S +
Sbjct: 402 AQVNNLSVIPACLGFAYVIFCAFGADLFRCKWIFMVFAAIMNTVSCALLIKWDIPSKAKW 461
Query: 471 WPTFALCTLLLGSPYVHAICVSWVSRNSNSIKTRALS-SALYNMAVQVGAIYSAQIYREN 529
+ F + SP + + ++ + + +A++ A+Y+ + A +
Sbjct: 462 YAFFTTYFSVAASPCLWSFINDFLRFDP---QVKAITWIAIYSFSQSTYAWIPTLAWPTV 518
Query: 530 DKPLYHTGNTVLFSLAVVTTPIFLFVKWYYHKRNKDKEAI 569
+ P + TG TV + ++ FV +++KRN+ K A+
Sbjct: 519 ESPRFKTGYTVSLIFGAI-YGLWTFVVLFFYKRNEKKHAL 557
>SPBC2G2.01c [G] KOG2533 Permease of the major facilitator superfamily
Length = 514
Score = 87.4 bits (215), Expect = 6e-17
Identities = 99/449 (22%), Positives = 187/449 (41%), Gaps = 36/449 (8%)
Query: 117 FDPEFTWTKEEEQKVVRKLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDY 176
F P + K E QK++ K++ + C + LDR +++ A + + EDL M+ N+
Sbjct: 11 FSPYYGLNKVE-QKLLIKIDWFILSYCCVSYFINYLDRSSINNAYLSGMQEDLKMHGNEL 69
Query: 177 NLGNQIFYISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGFFICRCL 236
N +F +++ ++P +R+ ++ + W ++ + A+H+ I R
Sbjct: 70 QDINVVFTCGYIIGQLPGSYALQRVPARLWFSVMNILWGLMTIFSFAVHSVRALMILRFF 129
Query: 237 IGALEGGFIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGI-LRMRGIGGL 295
+ E A L ++ E R F S + + + L + + G GGL
Sbjct: 130 MAVAEASTFAGTHYILGAWYKESELCKRAGIFSASGLVGTMFAGYLQTAVHSSLNGKGGL 189
Query: 296 AGWQYLFLLEGILTFFIGLTGFYLMVPSAVQTKNWMHPKGWFTEREEKIVVNRVLRDDPS 355
+GW++LF+++GILT + L G +L TK +FTE+E+++ R+ P+
Sbjct: 190 SGWRWLFIIDGILTIPLSLYGLFLFPDVPETTK-----APYFTEQEKELSFKRL----PA 240
Query: 356 KGDMHNRQPISFKLIWSAISDYDLWPI----YFIGLIAYVPTNVXXXXXXXXXKSVGFST 411
+ ++P++ K I + + ++ + F G + NV FS
Sbjct: 241 R---PKKKPLTLKAIKDIVRSWRIYGLCILWIFSGETQAIAVNVLMGQWMKWSNK--FSV 295
Query: 412 FNVQLLSIPYQVIHIIFLLGITWFSERV--KQRAYMGIISAVWNAFFLAILRWWKGSLVE 469
+ + ++ LG + S+++ R G+ V IL W ++ +
Sbjct: 296 AQINNYPTVITAVGVVSTLGASVISDKLAGNPRWPFGLFLCVITTVSATILLAW--NVPD 353
Query: 470 AWPTFALCTLLLGSPYV-HAICVSW---VSRNSNSIKTRALSSALYNMAVQVGAIYSAQI 525
FA G Y A+ SW + R+++ + R + L NM + I+ A I
Sbjct: 354 GAKFFAY--FASGCTYAGQAVWFSWANDICRDND--QERGVVVFLMNMCQNIWHIWWAPI 409
Query: 526 -YRENDKPLYHTGNTVLFSLAVVTTPIFL 553
Y D P + G L L VV +F+
Sbjct: 410 MYPNTDTPRFIKG---LIGLLVVGGIVFV 435
>SPAC1B3.15c [G] KOG2533 Permease of the major facilitator superfamily
Length = 628
Score = 74.3 bits (181), Expect = 5e-13
Identities = 84/404 (20%), Positives = 171/404 (41%), Gaps = 47/404 (11%)
Query: 127 EEQKVV----RKLNIRVALVACYLFVALQLDRG---NLSQAVVDN------LLEDL-GMN 172
EE+K++ RKL++R+ + C L++ L R ++S ++ N LL+ + G+N
Sbjct: 141 EEKKILSRIRRKLDLRI--ITC-LWITYFLSRSVTYSISLSLTMNKHQGHSLLQTVSGLN 197
Query: 173 RNDYNLGNQIFYISFLLAEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNK----T 228
+ ++G + Y+S ++ ++PS L+ R P +++ + ++ A + K +
Sbjct: 198 YHTLSVGTGLSYVSLIIFDLPSNLLMTRADPRLWLSRIQVTTGIIGACHAVLGTKGSSAS 257
Query: 229 GFFICRCLIGALEGGFIADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILR 288
GF R G G + + F+ + R+ W++T+ + + +++L+ +
Sbjct: 258 GFIALRFFNGLAIAGMWPGFAFYTSRFYRDQHLGKRIGWYYTAAQISSVATSLLSAAFQK 317
Query: 289 MRGIGGLAGWQYLFLLEGILTFFIGLTGFYLMVPSAVQ-TKNWMHPKGWFTEREEKIVVN 347
M G+ GL G+Q++FL+ G++ F G L +P + K+ H + W + +
Sbjct: 318 MDGLHGLYGYQWMFLIWGVVAFTQG-----LFLPRWLPCIKHNQHNEKWISWIRIPKFLG 372
Query: 348 RVLRDD-----PSKGDMHNRQPISFKL--------IWSAISDYDLWP--IYFIGLIAYVP 392
+ + P + ++H ++ + A D LWP F G++
Sbjct: 373 FLKASENTGLTPEEEEVHAIYMAEMQVGKSWTLTDLADAFLDVRLWPPIFMFFGVVGISN 432
Query: 393 TNVXXXXXXXXXKSVGFSTFNVQLLSIPYQVIHIIFLLGITWFSERVKQRAYMGIISAVW 452
V + FS+ V LL P V I +L + +R ++ + S ++
Sbjct: 433 GLVNYSSLIISEINENFSSVTVSLLVAPIWVFDAIAILTVLPLHDRFHKKMLFFVGSCLF 492
Query: 453 NAFFLAILRWWKGSLVEAWPTF-ALCTLLLGSPYVHAICVSWVS 495
L I + + W + L L G I ++WVS
Sbjct: 493 VLAGLLITTF----VSNVWGRYVGLLILGFGLGPTVPIIMTWVS 532
>SPAC1B3.16c [G] KOG2533 Permease of the major facilitator superfamily
Length = 568
Score = 70.1 bits (170), Expect = 9e-12
Identities = 56/243 (23%), Positives = 114/243 (46%), Gaps = 16/243 (6%)
Query: 79 VEIRSQDSLTSDNPFSDPKIAEYYRALYDDSKYESRSAFDPEFTWTKEEE-QKVVRKLNI 137
VE S + N FS I +++D + + EFT ++ QK+ K+++
Sbjct: 26 VESVSDSKPSLKNQFSTTVIDSSDLNVFNDGA--ETTVKEQEFTSSELRRLQKLRLKMDL 83
Query: 138 RVA-------LVACYLFVALQLDRGNLSQAVVDNLLEDL-GMNRNDYNLGNQIFYISFLL 189
R+ ++C L + L ++ A +L++ L G + + LG +FY+ +++
Sbjct: 84 RIIPCLWILYFLSCCLRFTVSLSF-TMNTAQGHSLIQTLSGYSAHYLALGLALFYVGYII 142
Query: 190 AEIPSQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTG----FFICRCLIGALEGGFI 245
E+PS L+ + P I++ + VV A + K G + R +G E G
Sbjct: 143 FEVPSNLMMAFIEPRIWVSRIQLTIGVVGACHAVLGTKHGNAQSYVALRFFLGVAESGLW 202
Query: 246 ADLVLWLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGILRMRGIGGLAGWQYLFLLE 305
L +++ ++ K R+ W++T+ + ++++ G +M G GL G+Q++FL+
Sbjct: 203 PGLAYYMSRWYRGKHLGKRIGWYYTAAQIAAAAVSLVSAGFQKMDGARGLYGYQWMFLIW 262
Query: 306 GIL 308
G++
Sbjct: 263 GVV 265
>YCR028c [G] KOG2533 Permease of the major facilitator superfamily
Length = 512
Score = 64.3 bits (155), Expect = 5e-10
Identities = 47/188 (25%), Positives = 86/188 (45%), Gaps = 7/188 (3%)
Query: 134 KLNIRVALVACYLFVALQLDRGNLSQAVVDNLLEDLGMNRNDYNLGNQIFYISFLLAEIP 193
K+++ V C + +DR + A + + EDL M ND + N +F I +++ +P
Sbjct: 32 KIDLFVLSFVCLQYWINYVDRVGFTNAYISGMKEDLKMVGNDLTVSNTVFMIGYIVGMVP 91
Query: 194 SQLISKRLGPDIFIPIQICSWSVVAMAQAAMHNKTGF-FIC--RCLIGALEGGFIADLVL 250
+ L+ + P I++ +W ++ + M+ T F IC R E +
Sbjct: 92 NNLMLLCVPPRIWLSFCTFAWGLLTL---GMYKVTSFKHICAIRFFQALFESCTFSGTHF 148
Query: 251 WLTYFFTSKEFSIRLSWFWTSLSLVQILSAILAYGIL-RMRGIGGLAGWQYLFLLEGILT 309
L ++ E IR + F S + + S + I + G GLAGW++LF+++ +T
Sbjct: 149 VLGSWYKEDELPIRSAIFTGSGLVGSMFSGFMQTSIFTHLNGRNGLAGWRWLFIIDFCIT 208
Query: 310 FFIGLTGF 317
I + GF
Sbjct: 209 LPIAIYGF 216
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.324 0.138 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,194,623
Number of Sequences: 60738
Number of extensions: 1471900
Number of successful extensions: 4616
Number of sequences better than 1.0e-05: 22
Number of HSP's better than 0.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 4552
Number of HSP's gapped (non-prelim): 24
length of query: 599
length of database: 30,389,216
effective HSP length: 112
effective length of query: 487
effective length of database: 23,586,560
effective search space: 11486654720
effective search space used: 11486654720
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)