ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV2041 good DO KOG1858 Cell cycle control, cell division, chromosome partitioning Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24)
r_klactIV2041 good DO KOG1858 Posttranslational modification, protein turnover, chaperones Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV2041 696760 691910 -1617
(1617 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL172w [DO] KOG1858 Anaphase-promoting complex (APC) subunit 1 ... 708 0.0
SPBC106.09 [DO] KOG1858 Anaphase-promoting complex (APC) subunit... 284 7e-76
Hs12056971 [DO] KOG1858 Anaphase-promoting complex (APC) subunit... 223 3e-57
7293070 [DO] KOG1858 Anaphase-promoting complex (APC) subunit 1 ... 202 5e-51
At5g05560 [DO] KOG1858 Anaphase-promoting complex (APC) subunit ... 181 1e-44
CE21288 [DO] KOG1858 Anaphase-promoting complex (APC) subunit 1 ... 135 4e-31
>YNL172w [DO] KOG1858 Anaphase-promoting complex (APC) subunit 1 (meiotic
check point regulator/Tsg24)
Length = 1748
Score = 708 bits (1828), Expect = 0.0
Identities = 500/1739 (28%), Positives = 829/1739 (46%), Gaps = 183/1739 (10%)
Query: 18 GQLWV--DNNSVEWWSEGSCLRRYNFDTPVIFSGFKRWDDLGLTLCIVLKDAVHFHYLSD 75
G +W+ D SV+W E CLR++ ++ +I +G+ ++ +VL D H + L +
Sbjct: 43 GDIWLSRDGRSVKWCIEDQCLRQFTYNQKIIKAGYIDFEKTPDCFVVVLSDIAHVYMLKN 102
Query: 76 NDSFVVSLPFHTSKACIFKNGLILQRVMQPDTLDYNANFE------NYRFICITHPMSPF 129
S V PF A + NG+IL+R +D + + +++I +T PM+PF
Sbjct: 103 GGSTTVCFPFQIGNAFWYANGVILERETSASFMDGGYDLKPIEFDLKHKYITLTDPMAPF 162
Query: 130 GSIQFPST---------ASPTD-LNDIELIYFPKADSFGVALFYQRTTEQLFFYSIQLL- 178
G I +T + TD L D +L+ FP +A+F R ++ L FY ++L
Sbjct: 163 GLISITNTFKGGINSASGNKTDILQDFQLVLFPSDKDKCIAVFLDRNSKVLRFYYSRILS 222
Query: 179 --QDSSDSVTLKS-PTLSLDS----------SNSVRKKSYGNLAPNTPGSSASLSNAIQR 225
Q +T+ S LD+ S +RK S+ + S++ NA +R
Sbjct: 223 SDQSRKGELTISSTKKTGLDAAGNSQKSGGISKDLRKFSHLTRRSTSINSNSHDFNAAER 282
Query: 226 RKTSDIPYGFXXXXXXXXXRKRSAYNRRATSTNWTAEDTNSEMTNTLHVSAKLAQTPXXX 285
+ ++ S+ +RR+ S N TN P
Sbjct: 283 VLSGNVG---NASGRTDIFALPSSCSRRSLSATLDRMGNNIAPTN--------RAAPSGF 331
Query: 286 XXXXXXXXXXXTNVERIMEMTPTMNAPDQSISSDISKDVYLTKITAVKVP---------- 335
+N+ + + + ++ SKD+ LT+I+++K+P
Sbjct: 332 FDSSSANTATHSNITPVSQPMQQQQQEYLNQTATSSKDIVLTEISSLKLPDDIIFTSRRL 391
Query: 336 -SLSSKGKVVSTKMGDKQAIGILDNVNGWGKIWIFNLNNSVMTNVRFKAFGYSPISMTKT 394
S+ SK K +S + ++ + I + KIW+ +L V+ ++ FK +G SP +M +
Sbjct: 392 SSILSKLKFLSLRFERREGLLIFHEPTHFCKIWLIDLLPDVLDSIPFKIYGNSPQNMIRL 451
Query: 395 MDIK---PGIVRDVCVYNSED----LIGYFAFLQKDTLILYNPYLEITSPEFQLHVSSPX 447
++K P ++ + ++ + L+ ++ LY+P+++ITSP +
Sbjct: 452 ENLKLKEPSRIQAMYIHELLESCLILVSEGQNKEEYKACLYDPFVKITSPSKNI------ 505
Query: 448 XXXXXXXXXXXXXXXXXWEIVPSPHTYPTGNALKSIFIGIKYVLHETFHL-FLAIWQAQR 506
++ P YP + K F +KY+ F++ F+ +WQ+
Sbjct: 506 ----SEELTKQNSLPSLQKLFP----YPETSFTKLCFEAVKYITSPAFNISFIFLWQSAY 557
Query: 507 S-ELEKSNTSPLHVADSDQDFIALQNTILLNLDNCNDTFAHPLYKE-------------- 551
S L ++N + + D +L ++L+ + + YKE
Sbjct: 558 SILLSRANDDVVGGLKMEHDAFSLVLSLLILPIPSSSAQEYQEYKEIYERDLFQHLKQDS 617
Query: 552 --DPSWLAKVTMCLHLMREEFQLNIYELEIVNKLARLLTNLTSLMNWPQIWIDYYHSPED 609
S L ++ + LHL+REE+ LN+ L + L T+ M WP +W YY D
Sbjct: 618 EITSSVLPRIVIGLHLIREEYSLNVLCRNEHALLGQFLRFATAAMGWPDLWQSYYVPKMD 677
Query: 610 R-----LHP--LTIVFDQPIDEPPSIFKTLYSARQQSHVPLTPFITLSRLINDDSCDIDD 662
LHP F P+DEPPSI K+LYS + S +PL PFI+ SRL+ D+ ++
Sbjct: 678 SESKTFLHPREQNSTFFHPLDEPPSITKSLYSITENSSIPLCPFISFSRLVATDT-QVEL 736
Query: 663 IVTPLTNKMLKLFQ--SXXXXXXXXXXXXXXXXXIGKTELEALPVGIYVPLKRLLLDVEN 720
+TP + K+L L++ + K EL+ P+GI VPL+ +L +E+
Sbjct: 737 RITPRSFKILGLYELVHSPNFLPDYVLGILSSFKVDKDELQTYPLGILVPLQNILKILED 796
Query: 721 EIDHVDENVXXXXXXXXX--XXXXKDFISSQQQKKLPGQFKSQNISNI--------ASSE 770
++ V +N+ S ++ GQ S + + S +
Sbjct: 797 KLSEVRDNLELLDRADLQRCSAIINSIRSDSKEVLKRGQRDSYMLCKVPLAKNRSSLSKK 856
Query: 771 PRSILQIYKQIAEKSLNVSSKSSKIESINY----------DMISTKKPIFNHKELFLDFV 820
P I I +I + + V S + N + IF+ + F V
Sbjct: 857 PSDIYSILSEIVKSASQVPLDGSAMRMSNIQDDEDIDEGRSLKLNAGLIFSEDKRFTHVV 916
Query: 821 KTLSYSKTHSVDLPKLKLDYSNLLILKKRTATAMAYRALTSGFGYAASFLCSDPTLNQHN 880
L+Y + K +Y+ +L KK A MA R T+G G+ A ++ ++
Sbjct: 917 SLLAYYRPTKTQFFTTKTEYAQILAQKKYFAKIMALRTCTNGVGWGAVAYATEKPISTQK 976
Query: 881 FVEDSLSLSFHFDVDDTVISLEKNSFPDDILGWGAFHRGVAKGLALDTDKKPLTSGWLNF 940
+V L+L F D + DI+ WG FH GV+ GL + +T W+ F
Sbjct: 977 WVIQPLNLISVFPDDTKITVKAPEDIAHDIVEWGQFHAGVSSGLRISKKATGITGSWIAF 1036
Query: 941 NNQDVLDPEYGGFLLGLGLNRHLSVLGEWQLYNFLSPKNTYVSIGLLLGMCVSMRGSMSL 1000
N LD +GGFLLGLGLN HL L EW +YN+LSP+NT++SIGLLLGM SM+GSM
Sbjct: 1037 NKPKELDAYHGGFLLGLGLNGHLKNLEEWHIYNYLSPRNTHISIGLLLGMSSSMKGSMDS 1096
Query: 1001 KMTKVLSVHVLALLPPGSSNLNIDYKIQSAGLVGLGILYENTHNRRISELFSNELTSSIN 1060
K+ KV+SVH++A LP GSS+LNID K+Q+AG++G+G+LY N+ ++R+S+ +L S +N
Sbjct: 1097 KLIKVISVHLVAFLPSGSSDLNIDLKLQTAGIIGMGMLYLNSRHKRMSDSIFAQLVSLLN 1156
Query: 1061 INDENVPDEGYRLACGIGIGLINMGCGEKSTNPKAGGDFDDYNSHHPKGSIDPQDTNEGD 1120
+NDE V DE YRLA GI +GLIN+G G+ K P+ D D +
Sbjct: 1157 VNDEMVADEEYRLAAGISLGLINLGAGQTKLR-KWDSSLLGLGDDLPEDVYDSSDVEQ-- 1213
Query: 1121 RSFDFSFKSGTMDPKIIEKLVNIVVSVNDVGEDWMPVNSQLGALIALMLVFLKTNCQTIA 1180
M + KL+ IV S DV DW+P NSQ+GA+IA+M +FLK+N I+
Sbjct: 1214 ---------NVMYEDLTTKLLEIVTSTYDVENDWIPENSQIGAVIAIMFLFLKSNNFGIS 1264
Query: 1181 DTISVSKPKEEVDSSIYTRPDLFIYREWCVNMIMWDKIPLDWRWILEILPRSFDPKNVTS 1240
+ + V KE + ++I TRP+L +YREW NMI+W+ I D +I++ + + +
Sbjct: 1265 NMLKVDL-KEILKANINTRPELLMYREWASNMILWEFIGDDLSFIMKDVDIGVKFSELNT 1323
Query: 1241 DILPIYYRIAGRCLSVGVKGASSNSISLREGLCRILDMFLPMYQYSLEKRVDSQLLFKGI 1300
D+LPIYY +AGR L++G++ AS+ ++ +R L ++D FLP+YQY ++ +D +L I
Sbjct: 1324 DLLPIYYTMAGRILAMGIRFASTGNLKIRNILLSLVDKFLPLYQYPGKQNLDFRLTISVI 1383
Query: 1301 TNLINCVVLAMSLIMAGSGDIEVYKRIRYLHSVSHGRNSYLYS---MSRKD--------- 1348
L N +V+++S++M SGD+EV +R++YLH V+ G S L+ S+ D
Sbjct: 1384 NVLTNVIVVSLSMVMCASGDLEVLRRVKYLHEVASGPYSDLFQEIPSSKSDVSGVTQVTS 1443
Query: 1349 ----PSNTFEEVEEEILNIGIAERPKN--------------VDYDNHYGKFMTTNMCMGF 1390
P N+ E +E ER N D D+HYGKF++TN+ +GF
Sbjct: 1444 NTNTPGNSDRERVDETAASLDDERSSNGSDISDPTAYLEDKKDIDDHYGKFISTNLALGF 1503
Query: 1391 LFLGLGHYALRTANIKDLSYLIISVIPTFNSPYYLQETKYLWRLAMSERFLLVRDATTEE 1450
LFLG G YAL T+ ++ +++L +SV+PT+ +P+ LQE K+ W +A+ R L+++D +T +
Sbjct: 1504 LFLGSGQYALNTSTLESIAFLSMSVLPTYTTPHPLQELKHFWSIAVEPRCLVIKDISTGD 1563
Query: 1451 LISDVPL-LITSKDTKSNEVLHEMKSPCLLPVIESIVRIQVRAPMYYPLTLEFGENKLNI 1509
+++VP+ L+ +D + EV+ E+ +PCLLP I I+V+ Y+PL + F ++ +
Sbjct: 1564 AVNNVPIELVVEEDVEKEEVIREISTPCLLPDFSKIKSIRVKMHGYFPLEVNFTKD-YSA 1622
Query: 1510 DKFFEKGCFIHVKKRSIEDYGKLGEKTAKNDLKAMYYKSLLTQRTANSLLGDTSEEKKSF 1569
FF G I+++++S + D+ + + + L + +
Sbjct: 1623 SDFFSGGTIIYIQRKSESVFENKASFRNVEDIHVALKRKAAESKNYSRLNLKNEQGNTTS 1682
Query: 1570 YEEFCSKNVEDLELAHYQ-----------NPTQEFNLNLL----TGLDSFDFELEIWRK 1613
+ S ++DL + ++ +NL LL D D +LE+W K
Sbjct: 1683 SQLVESLGIQDLTMVELDTLLSAGNNTALTDSESYNLGLLCSDKNSGDILDCQLELWYK 1741
>SPBC106.09 [DO] KOG1858 Anaphase-promoting complex (APC) subunit 1 (meiotic
check point regulator/Tsg24)
Length = 1458
Score = 284 bits (727), Expect = 7e-76
Identities = 253/981 (25%), Positives = 426/981 (42%), Gaps = 141/981 (14%)
Query: 545 AHPLYKEDPSWLAKVTMCLHLMREEFQLNIYELEIVNKLARLLTNLTSLMNWPQIWIDYY 604
+H Y ++L + + LH + EE +L+ ++L LL +T+ + WP+ + +YY
Sbjct: 453 SHLDYSTFKNYLMPLAITLHFISEELRLDSVVKPRKDQLVALLLQITTWLKWPR-YCEYY 511
Query: 605 HSPEDRLH---PLTIVFD--QPIDEPPSIFKTLYSA-RQQSHVPLTPFITLSRLINDDSC 658
+ PL+I D +P+ P SI + + R QS VP F L SC
Sbjct: 512 NFDIAETFLSIPLSIQVDVEEPVG-PTSILQWIIECLRSQSTVP---FYGLESYGLPHSC 567
Query: 659 DIDDIVTPLTNKMLKLFQSXXXXXXXXXXXXXXXXXIG--KTELEALPVGIYVPLKRLLL 716
+ P T +++L +G + E P GI + +L
Sbjct: 568 ST---MFPQTLSLMQLLDCLLNPNMTLQNLVEEMVRLGISRKRCERYPFGILCIIFTVL- 623
Query: 717 DVENEIDHVDENVXXXXXXXXXXXXXKDFISSQQQKKLPGQFKSQNISNIASSEPRSILQ 776
E + N F+ + K + N E + I
Sbjct: 624 --EIAAEEYSPNWESEELRLVNRLDVDSFLHPKTPKW---------VFNKQDQEVKEIKA 672
Query: 777 IYKQIAEKSLNVSSKSSKIESINYDMISTKKPIFNHKELFLDFVKTLSYSKTHSVDLPKL 836
+ + + +L V ++S + DMI F + K L+YS ++
Sbjct: 673 LTSTVTDSTL-VDTQSFHPYKVVTDMI------FREDRRLAEVNKLLNYSSQITIMTEHF 725
Query: 837 KLDYSNLLILKKRTATAMAYRALTSGFGYAASFLCSDPTLNQHNFVEDSLSLSFHFDVDD 896
+D S++ ++++ A + R L+ G S L + + H
Sbjct: 726 DVDLSSVP-MQQKVAQCICVRTLSVPIGAGMLTYGSKNPLPTEKVTPRLFNFTLHLHPGT 784
Query: 897 TVISLEKNSFPDDILGWGAFHRGVAKGLALDTDKKPLTSGWLNFNNQDVLDPEYGGFLLG 956
+I K ++ W F+ GVA GL++ K + + W+ FN + L + GFL G
Sbjct: 785 LIIQPNKEFVTQELTEWPEFNVGVALGLSISKFSKEINTSWIMFNRPETLTAYHAGFLFG 844
Query: 957 LGLNRHLSVLGEWQLYNFLSPKNTYVSIGLLLGMCVSMRGSMSLKMTKVLSVHVLALLPP 1016
LGLN HL L W + +L+ K+ SIGLLLG+ S GSM K+TK+LSVH+ ALLP
Sbjct: 845 LGLNGHLKALATWHSFIYLTSKHDTTSIGLLLGLASSYLGSMDAKVTKLLSVHISALLPV 904
Query: 1017 GSSNLNIDYKIQSAGLVGLGILYENTHNRRISELFSNELTSSININDENVPDEGYRLACG 1076
GS+ LNI Q+AG++G+G+L+ ++ +RR+SE+ E+ +S N+ + +EGY+LA G
Sbjct: 905 GSNELNISPLTQTAGILGIGLLFHDSCHRRMSEVTMEEILAS---NESELKNEGYKLAAG 961
Query: 1077 IGIGLINMGCGEKSTNPKAGGDFDDYNSHHPKGSIDPQDTNEGDRSFDFSFKSGTMDPKI 1136
+GLIN+G G S G D K+
Sbjct: 962 FSLGLINLGRG--------------------------------------SNLPGMSDLKL 983
Query: 1137 IEKLVNIVVSVNDVGEDWMPVNSQLGALIALMLVFLKTNCQTIADTISVSKPKEEVDSSI 1196
+ +L V ++ GA++AL ++++KTN +A I + K + +D
Sbjct: 984 VSRL---QVGISSQATFQSLEAGSPGAIMALTMIYMKTNDLEVAKKIDIPKSRYLLD--- 1037
Query: 1197 YTRPDLFIYREWCVNMIMWDKIPLDWRW----ILEILPRSFD---PKNVTSDILPIYYRI 1249
+ RPDL + R N+IMWD++ D+ W I +I+ FD K ++SD L +Y +
Sbjct: 1038 FYRPDLILLRVAGKNLIMWDEVKADYEWVKYQIPDIMLSQFDLQEKKVLSSDDLLLYNVL 1097
Query: 1250 AGRCLSVGVKGASSNSISLREGLCRILDMFLPMYQYSLEKRVDSQLLFKGITNLINCVVL 1309
AG C S+G++ A + + +E L LD F+ + K D ++ + V L
Sbjct: 1098 AGICFSLGLRFAGTGNPKAKEILINFLDSFIRLCHLP-AKTHDERVTAVTVIRCTQIVAL 1156
Query: 1310 AMSLIMAGSGDIEVYKRIRYLHSVSHGRNSYLYSMSRKDPSNTFEEVEEEILNIGIAERP 1369
+ S +MAG D++V +R+R LH R +P N
Sbjct: 1157 SSSCVMAGYCDLDVLRRLRVLH-------------GRMEPVN------------------ 1185
Query: 1370 KNVDYDNHYGKFMTTNMCMGFLFLGLGHYALRTANIKDLSYLIISVIPTF-----NSPYY 1424
YG M T+M +G L LG G Y+L +N+ ++ L+IS P F ++ +
Sbjct: 1186 --------YGAQMATHMALGILSLGGGRYSLSRSNLA-IAALLISFYPQFPRTTQDNRAH 1236
Query: 1425 LQETKYLWRLAMSERFLLVRDATTEELISDVPLLITSKDTKSNEVLHEMKSPCLLPVIES 1484
LQ + LW LA+ ER ++ R+ T++ P ++ + + + ++++P LLP +S
Sbjct: 1237 LQAARNLWALAVEERCIIPRNQDTKQ-----PCIVPLNVVQKSGAVQKLEAPILLPPYDS 1291
Query: 1485 IVRIQVRAPMYYPLTLEFGEN 1505
I + Y+ L ++ N
Sbjct: 1292 ISSVSTLGDKYWNLKIDLDNN 1312
>Hs12056971 [DO] KOG1858 Anaphase-promoting complex (APC) subunit 1 (meiotic
check point regulator/Tsg24)
Length = 1944
Score = 223 bits (567), Expect = 3e-57
Identities = 273/1181 (23%), Positives = 490/1181 (41%), Gaps = 220/1181 (18%)
Query: 488 KYVLHETFHLFLAIWQAQRSE-LEKSNTSPLHVADSDQDFIALQNTILLNLDNCNDTFAH 546
+Y+L+ +H + RS L S S + D+DF QN L+LD+ F H
Sbjct: 708 EYLLNSDYHQNVESHLLNRSLCLSPSEASQM----KDEDFS--QN---LSLDSSTLLFTH 758
Query: 547 PLYKEDPSWLAKVTMCLHLMREEFQLNIYELEIVNKLARLLTNLTSLMNWPQIWIDYYHS 606
+ + LHL+ EE +LN E + L LL L + ++D+Y+
Sbjct: 759 ---------IPAIFFVLHLVYEELKLNTLMGEGICSLVELLVQLARDLKLGP-YVDHYYR 808
Query: 607 PEDRLHPLT--IVFDQP------------IDEPPSIFKTLYSARQQSHVPLTPFIT---- 648
L T + P EPPSI++ + S + +P P++
Sbjct: 809 DYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKGEGMPPYPYLPGICE 868
Query: 649 LSRLI---------NDDSCDIDD---IVTPLTNKMLKL----------FQSXXXXXXXXX 686
SRL+ D+S D+ +T +T KL F+
Sbjct: 869 RSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAE 928
Query: 687 XXXXXXXXIGKT--ELEALPVGIYVPLKRLLLDVENEIDHVDENVXXXXXXXXXXXXXKD 744
+G T +LE LP GI +P++ + I H E +
Sbjct: 929 RLVVWMTNVGFTLRDLETLPFGIALPIR-------DAIYHCREQPASDWPEAVCLLIGRQ 981
Query: 745 FISSQQQKKLPGQFKSQNISNIASSEPRSILQIYKQIAEKSLNVSSKSSKIESINYDMIS 804
+S Q + + KS S++ S + + +N++++S
Sbjct: 982 DLSKQACEGNLPKGKSVLSSDVPSGT----------------ETEEEDDGMNDMNHEVMS 1025
Query: 805 TKKPIFNHKELFLDFVKTLSYS----KTHSVDLPKLKLDYSNLLILKKRTATAMAYRALT 860
+ ++L + V+ L S + + V P+L D+ + K+ + R +
Sbjct: 1026 ----LIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELS-DHE-FIEEKENRLLQLCQRTMA 1079
Query: 861 SGFGYAASFLCSDPTLNQHNFVEDSLSLSFHFDVDDTVISLEKNSF--PDDILGWGAFHR 918
G L S + L+L+ +T + L + P ++ W +FH
Sbjct: 1080 LPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHN 1139
Query: 919 GVAKGLALDTDKKPLTSGWLNFNNQD--VLDPEYGGFLLGLGLNRHLSVLGEWQLYNFLS 976
GVA GL + + S W+ +N L EY GFL+ LGLN HL+ L ++++L+
Sbjct: 1140 GVAAGLKI-APASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLT 1198
Query: 977 PKNTYVSIGLLLGMCVSMRGSMSLKMTKVLSVHVLALLPPGSSNLNIDYKIQSAGLVGLG 1036
+ SIGLLLG+ + G+M + +T++LS+H+ ALLPP S+ L++ + +Q A +VG+G
Sbjct: 1199 KGHEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIG 1258
Query: 1037 ILYENTHNRRISELFSNELTSSININDENVPD-EGYRLACGIGIGLINMGCGEKSTNPKA 1095
++Y+ T +R +E+ E+ E D E Y LA G+ +G++ +G
Sbjct: 1259 LVYQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLG---------- 1308
Query: 1096 GGDFDDYNSHHPKGSIDPQDTNEGDRSFDF------SFKSGTMDPKIIEKLVNIVVSVND 1149
H I D N ++ + + F++G K K + + D
Sbjct: 1309 ----------HGSNLIGMSDLNVPEQLYQYMVGGHRRFQTGMHREK--HKSPSYQIKEGD 1356
Query: 1150 VGEDWMPVNSQL---GALIALMLVFLKTNCQTIADTISVSKPKEEVDSSIYTRPDLFIYR 1206
+N + GA +AL +++LKTN ++IAD + +D + +P+ + R
Sbjct: 1357 T------INVDVTCPGATLALAMIYLKTNNRSIADWLRAPDTMYLLD---FVKPEFLLLR 1407
Query: 1207 EWCVNMIMWDKIPLDWRWILEILPRSFDPKNVTSDILPI---------------YYRIAG 1251
+I+WD I + +W+ +P+ +++ + + Y IAG
Sbjct: 1408 TLARCLILWDDILPNSKWVDSNVPQIIRENSISLSEIELPCSEDLNLETLSQAHVYIIAG 1467
Query: 1252 RCLSVGVKGASSNSISLREGLCRILDMFLPMYQYSLEKRVDSQLLFKGITNLINCVVLAM 1311
CLS+G + A S ++S L + F+ Y + V + ++ V+L++
Sbjct: 1468 ACLSLGFRFAGSENLSAFNCLHKFAKDFM-TYLSAPNASVTGP---HNLETCLSVVLLSL 1523
Query: 1312 SLIMAGSGDIEVYKRIRYLHSVSHGRNSYLYSMSRKDPSNTFEEVEEEILNIGIAERPKN 1371
+++MAGSG+++V + R+LH + G
Sbjct: 1524 AMVMAGSGNLKVLQLCRFLHMKTGG----------------------------------- 1548
Query: 1372 VDYDNHYGKFMTTNMCMGFLFLGLGHYALRTANIKDLSYLIISVIPTF-----NSPYYLQ 1426
+ +YG + +M +G LFLG G Y+L T+N ++ L+ ++ P F ++ Y+LQ
Sbjct: 1549 ---EMNYGFHLAHHMALGLLFLGGGRYSLSTSN-SSIAALLCALYPHFPAHSTDNRYHLQ 1604
Query: 1427 ETKYLWRLAMSERFLLVRDATTEELISDVPLLITSKDTK-SNEVLHEMKSPCLLPVIESI 1485
++L+ LA R L+ D T + L +T K T+ + E+ +P LLP + +
Sbjct: 1605 ALRHLYVLAAEPRLLVPVDVDTNTPCYAL-LEVTYKGTQWYEQTKEELMAPTLLPELHLL 1663
Query: 1486 VRIQVRAPMYYPLTLEFGENKLNIDKFFEKGCFIHVKKRSIEDYGKLGEKTAKNDLKAMY 1545
+I+V+ P Y+ L ++ + ++ K ++VK R+ G+ + K D M
Sbjct: 1664 KQIKVKGPRYWELLIDLSKGTQHLKSILSKDGVLYVKLRA-------GQLSYKED--PMG 1714
Query: 1546 YKSLLTQRTANSLLGDTSEEKKSFYEEFCSKNVEDLELAHY 1586
++SLL Q AN + E ++F E S D L +
Sbjct: 1715 WQSLLAQTVAN-----RNSEARAFKPETISAFTSDPALLSF 1750
>7293070 [DO] KOG1858 Anaphase-promoting complex (APC) subunit 1 (meiotic
check point regulator/Tsg24)
Length = 2030
Score = 202 bits (513), Expect = 5e-51
Identities = 178/690 (25%), Positives = 311/690 (44%), Gaps = 107/690 (15%)
Query: 897 TVISLEKNSFPDDILGWGAFHRGVAKGLALDTDKKPLTSGWLNFNNQDVLDP---EYGGF 953
T I +++ FP ++ W +FH GVA GL + + + S W+ +N E+ GF
Sbjct: 1189 TTIEMQQIEFPANMQMWPSFHNGVATGLKISPQAQDIDSNWIVYNKPKTHSHNALEHAGF 1248
Query: 954 LLGLGLNRHLSVLGEWQLYNFLSPKNTYVSIGLLLGMCVSMRGSMSLKMTKVLSVHVLAL 1013
L+ LGLN HL L +Y +L + ++GLLLG+ + RG+M K TK+LSVH+ AL
Sbjct: 1249 LMALGLNGHLKTLSFMSVYKYLVKCDEMTNVGLLLGISAAHRGTMDTKTTKLLSVHLEAL 1308
Query: 1014 LPPGSSNLNIDYKIQSAGLVGLGILYENTHNRRISELFSNELTSSININDEN-VPDEGYR 1072
LP + L+I Q A ++G+G+LY+ + R I+E+ E+ EN + E Y
Sbjct: 1309 LPATAMELDIPQSTQVAAIMGVGLLYQGSAKRHIAEVLLQEIGRPPGPEMENSIERESYA 1368
Query: 1073 LACGIGIGLINMGCGEKSTNPKAGGDFDDYNSHHPKGSIDPQDTNEGDRSFDFSFKSGTM 1132
+ G+ +GL+ +G GE + D + + G P ++ ++ SF+
Sbjct: 1369 MTAGLSLGLVTLGQGESPAGLRDLQLPDTLHYYMVGGVKRPIGGSQKEKYRLASFQVREG 1428
Query: 1133 DPKIIEKLVNIVVSVNDVGEDWMPVNSQLGALIALMLVFLKTNCQTIADTISVSKPKEEV 1192
D VNI V+ GA +AL L+F + IA+ + + +
Sbjct: 1429 D------TVNIDVTAP-------------GATLALGLMFFNSGNAAIAEWMQPPDSRYLL 1469
Query: 1193 DSSIYTRPDLFIYREWCVNMIMWDKIPLDWRWILEILPRS-------------FDPKNVT 1239
D RPD + R +I+W + D W PR+ + P++
Sbjct: 1470 D---MVRPDFLLLRTISRGLILWQDVRPDNAWFQAQFPRALRAHLKLPFYENEYAPEDYD 1526
Query: 1240 SD---ILPIYYRI-AGRCLSVGVKGASSNSISLREGLCRILDMFL-----PMYQYSLEKR 1290
D I Y I AG +G+K A + ++ L ++ FL PM + +
Sbjct: 1527 VDYEAISQAYCNIMAGAAFCIGLKYAGTENLVAFATLRSVIKDFLRFPSRPMGECAGRTT 1586
Query: 1291 VDSQLLFKGITNLINCVVLAMSLIMAGSGDIEVYKRIRYLHSVSHGRNSYLYSMSRKDPS 1350
V+S L+ +++++SL+ AGSG+ E+ + IR+L S + + P
Sbjct: 1587 VESCLM---------VLLISISLVFAGSGNCEILRIIRFLRS----------RVGPQYPH 1627
Query: 1351 NTFEEVEEEILNIGIAERPKNVDYDNHYGKFMTTNMCMGFLFLGLGHYALRTANIKDLSY 1410
T YG M +M +G LFLG G + + + + ++
Sbjct: 1628 IT-------------------------YGSHMAIHMSLGLLFLGAGRFTI-SQTPESIAA 1661
Query: 1411 LIISVIPTF-----NSPYYLQETKYLWRLAMSERFLLVRDATTEEL-ISDVPLLITSKDT 1464
L+ + P F ++ Y+LQ ++L+ LA+ R L RD T +L ++++ +L +
Sbjct: 1662 LVCAFFPKFPIHSNDNRYHLQALRHLYVLAVEPRLFLPRDIDTNKLCLANISVL----EV 1717
Query: 1465 KSNEVLHEMKSPCLLPVIESIVRIQVRAPMYYPLTLEFGENKLNIDKFFEKGCFIHVKKR 1524
+ E+ +PC+LPV+ ++ ++ V Y+P+ E N ++K E I +KKR
Sbjct: 1718 GATELRRLPIAPCILPVLSTLQQVVVDDENYWPVCFERSRNWDQLEKALEMSAPIDIKKR 1777
Query: 1525 SIEDYGKLGEKTAKNDLKAMYYKSLLTQRT 1554
+ G L + LK+M ++L +++
Sbjct: 1778 T----GCLSHLEDPDRLKSMLAQTLTMEQS 1803
>At5g05560 [DO] KOG1858 Anaphase-promoting complex (APC) subunit 1 (meiotic
check point regulator/Tsg24)
Length = 1678
Score = 181 bits (458), Expect = 1e-44
Identities = 231/994 (23%), Positives = 402/994 (40%), Gaps = 151/994 (15%)
Query: 562 CLHLMREEFQLNIYELEIVNKLARLLTNLTSLMNWPQIWIDYYHSPEDRLHPLTIVFDQP 621
CLH + E +++ + ++ LA LL N+ ++ + ++DYY RL TI
Sbjct: 585 CLHAVYESLKMDNLRKQDLHHLAVLLCNIAKFLD-EKCYLDYYIRDFPRLST-TIGACTT 642
Query: 622 ID---EPPSIFKTLYSARQQSHVPLTPFITLSRLINDDSCDIDDIVTPLTNKMLKLF--- 675
+ +PP++F+ L + ++ + T F L LI D C I + + LF
Sbjct: 643 LSSSRKPPNLFRWLENCLRRGCLS-TNFDDLPDLIRRDGCSIVSWARKVVSFYSVLFGDK 701
Query: 676 ---------------QSXXXXXXXXXXXXXXXXXIGKTELEALPVGIYVPLKRLLLDVEN 720
G +L+ LP G+ +PL+ L D
Sbjct: 702 PEGRTLSSGVPCNIAPGSYSCNEELTILAMAGERFGLHQLDLLPSGVSLPLRHAL-DSCR 760
Query: 721 EIDHVDENVXXXXXXXXXXXXXKDFISSQQQKKLPGQFKSQNISNIASSEPRSILQIYKQ 780
E D F + K +F+ Q+ +++ S +L ++
Sbjct: 761 ESPPADWPAIAYVLLGREDMALSVFRNFSSSK----EFEMQSNTSLISMSIPYMLHLHPV 816
Query: 781 IAEKSLNVSSKSSKIESINYDMISTKKPIFNHKELFLDFVKTLSYSKTHSVDLPKLKLDY 840
I S ++ +++KIE N S + + E + L Y + L+L+
Sbjct: 817 IVPSSESIGLENTKIEDTN----SVDGSVIDGMEHIFNSYTQLRYGRD-------LRLNE 865
Query: 841 SNLLILKKRTATAMAYRALTSGFGYAASFLCSDPTLNQHNFVEDSLSLSFHF-DVDDTVI 899
L+ R AA+ SD Q F L L+ + ++
Sbjct: 866 VRRLLCSARPVVVQT----------AANPTISDQE-QQQAFTVPKLVLAGRLPSQQNAIV 914
Query: 900 SLEKNSFP-DDILGWGAFHRGVAKGLALDTDKKPLTSGWLNFNNQDVLDPEYGGFLLGLG 958
+L+ N ++ W FH VA GL L + ++ W+ +N + + G L GLG
Sbjct: 915 NLDPNIRNIQELKTWPEFHNAVAAGLRLAPLQGKVSRTWIRYNKPGEPNAVHAGLLFGLG 974
Query: 959 LNRHLSVLGEWQLYNFLSPKNTYVSIGLLLGMCVSMRGSMSLKMTKVLSVHVLALLPPGS 1018
L +L VL +Y + + + ++GL+LG+ S RG+M + K L HV A
Sbjct: 975 LQGYLHVLNLSDIYQYFTQDHESTTVGLMLGLAASYRGTMQPDIAKALFFHVPARYQASY 1034
Query: 1019 SNLNIDYKIQSAGLVGLGILYENTHNRRISELFSNELTSSININDENVPDEGYRLACGIG 1078
+ I +QSA LV +G+L+E + +++ +L E+ + D + EGY ++ G
Sbjct: 1035 TEFEIPTLLQSAALVSVGMLFEGSAHQQTMQLLLGEI-GRRSAGDNVLEREGYAVSAGFS 1093
Query: 1079 IGLINMGCGEKSTNPKAGGDFDDYNSHHPKGSIDPQDTNEGDRSFDFSFKSGTMDPKIIE 1138
+GL+ +G GGD GS+D N + + P + +
Sbjct: 1094 LGLVALG---------RGGD--------ALGSMDSL-VNRLLLYLGAKEERSILVPSLED 1135
Query: 1139 KLVNIVVSVNDVGEDWMPVNSQLGALIALMLVFLKTNCQTIADTISVSKPKEEVDSSIYT 1198
+ D + + + GA+IAL L++LKT + I +S+ + +++
Sbjct: 1136 H--RSAAQITDGSTSNVDITAP-GAIIALTLMYLKTESEVIFSKLSIPQTHYDLEC---V 1189
Query: 1199 RPDLFIYREWCVNMIMWDKIPLDWRWILEILPRSF---------DPKNV----TSDILPI 1245
RPD + R N+IMW +I WI +P D N+ ++
Sbjct: 1190 RPDFIMLRVIARNLIMWSRICPTCDWIQSQVPEVVKNGISQLRDDMDNMYEVDVEALVQA 1249
Query: 1246 YYRI-AGRCLSVGVKGASSNSISLREGL----CRILDMFLPM-------YQYSLEKRVDS 1293
Y I AG C+S+G++ A + + R+ L +L+ P+ + + K VD
Sbjct: 1250 YVNIVAGACISLGLRFAGTRDGNARDLLNSYALYLLNEIKPLSATPGNAFPRGISKFVDR 1309
Query: 1294 QLLFKGITNLINCVVLAMSLIMAGSGDIEVYKRIRYLHSVSHGRNSYLYSMSRKDPSNTF 1353
L + +++++S++MAGSGD++V++ +R+L S RNS
Sbjct: 1310 GTL----EMCLYLIIISLSVVMAGSGDLQVFRLLRFLRS----RNS-------------- 1347
Query: 1354 EEVEEEILNIGIAERPKNVDYDNHYGKFMTTNMCMGFLFLGLGHYALRTANIKDLSYLII 1413
D +YG M ++ GFLFLG G T N L+ L+I
Sbjct: 1348 ------------------ADGHANYGTQMAVSLATGFLFLGGGMRTFSTNN-GSLAMLLI 1388
Query: 1414 SVIPTF-----NSPYYLQETKYLWRLAMSERFLLVRDATTEELISDVPLLITSKDTK-SN 1467
++ P ++ +LQ ++L+ LA R+L D + L PL +T K+TK +
Sbjct: 1389 TLYPRLPSGPNDNRCHLQAFRHLYVLATEARWLQTIDVDS-GLPVYAPLEVTVKETKLYS 1447
Query: 1468 EVLHEMKSPCLLPVIESIVRIQVRAPMYYPLTLE 1501
E +PC+LP + RI V P Y+P +E
Sbjct: 1448 ETKFCEITPCILPERAILKRICVCGPRYWPQQIE 1481
>CE21288 [DO] KOG1858 Anaphase-promoting complex (APC) subunit 1 (meiotic
check point regulator/Tsg24)
Length = 1461
Score = 135 bits (341), Expect = 4e-31
Identities = 141/650 (21%), Positives = 279/650 (42%), Gaps = 109/650 (16%)
Query: 913 WGAFHRGVAKGLALDTDKKP-LTSGWLNFNNQDVLDPEY-GGFLLGLGLNRHLSVLGEWQ 970
WG F+ +A L + + + + + W+ ++++ GG LG GLN HL+ +
Sbjct: 702 WGNFYNSLASALRIGSSETVRIDNEWIVMVSKNIKSTAVIGGMTLGFGLNGHLAPFNMYH 761
Query: 971 LYNFLSPKNTYVSIGLLLGMCVSMRGSMSLKMTKVLSVHVLALLPPGSSNLNIDYKIQSA 1030
+ LS + + S+ LL+G+ S + +++ K+L+ ++ L+ P + +D+ IQ+A
Sbjct: 762 AHQMLSTFDKFHSVALLIGLSASNFTTCDVQIHKILATYLSFLMGPTPLEIKLDFTIQTA 821
Query: 1031 GLVGLGILYENTHNRRISELFSNELTSSININDENVPD-EGYRLACGIGIGLINMGCGEK 1089
+ GLG+L+ ++ N I++ NE+ + N ++E V D Y+L+ G +GLI +G G
Sbjct: 822 AISGLGLLFADSGNMTIAKKLVNEIGRAPNRDEEPVTDRNAYKLSAGFSLGLIMLGKGNG 881
Query: 1090 STNPKAGGDFDDYNSHHPKGSIDPQDTNEGDRSFDFSFKSGTMDPKIIEKLVNIVVS--- 1146
S + + + P S G R F + P ++ + N+ S
Sbjct: 882 SASTVI-----PFKQNIPPMSQRLIYMMNGMRRDKCVFLP-QVAPPVVNDVPNLPFSNGG 935
Query: 1147 -------VNDVGE-DWMPVN-SQLGALIALMLVFLKTNCQTIADTISVSKPKEEVDSSIY 1197
N V E +++ ++ S A IAL ++F+K N + IA+ +++ E++
Sbjct: 936 MMTSSQVANHVKESEYINIHQSAEPAAIALGMMFMKMNNEFIANALALPGTITELER--- 992
Query: 1198 TRPDLFIYREWCVNMIMWDKIPLDWRWILEILP------------------RSFDPKNVT 1239
+PD R ++MWD I ++ ++P R D + V
Sbjct: 993 LKPDSMYSRVLAQCLVMWDSIEPTHDFVKSLIPPVIREYATAALHFGVPIRRDEDGEEVH 1052
Query: 1240 SDI------------------LPIYYRIAGRCLSVGVKGAS---SNSISLREGLCRILDM 1278
I Y ++ C+++ +K +S N ++ RI++
Sbjct: 1053 EAINDAEEKYWAEIVDKGTVSQTFLYAVSAACMAIALKFSSCGGPNEKNIVNTAFRIIEY 1112
Query: 1279 FLPMYQYSLEKRVD----SQLLFKGI---TNLINCVVLAMSLIMAGSGDIEVYKRIRYLH 1331
+ + + D ++ G T+ ++ ++ AM+++ G+GD+EV + R L
Sbjct: 1113 YTKIVMPDGKSNKDMGSIRMCIYSGAYTRTSCLSMLITAMAILRVGTGDLEVMRYARLLR 1172
Query: 1332 SVSHGRNSYLYSMSRKDPSNTFEEVEEEILNIGIAERPKNVDYDNHYGKFMTTNMCMGFL 1391
+ ++ + + FE+ M + +G L
Sbjct: 1173 LCDKPESDWIATGKKH-----FEQ--------------------------MVAHQALGIL 1201
Query: 1392 FLGLGHYALRTANIKDLSYLIISVIPTF-----NSPYYLQETKYLWRLAMSERFLLVRDA 1446
LG G YA + ++ ++ IIS PT ++ +Y Q ++LW +A+ R L+ D
Sbjct: 1202 MLGEGRYAFKKDDL-SIALTIISTFPTIPQSVSDNSHYHQPLRFLWSMAVEPRLLVPFD- 1259
Query: 1447 TTEELISDVPLLITSKDTKSNE-VLHEMKSPCLLPVIESIVRIQVRAPMY 1495
E + +V + I K NE ++++ K+P LLP +E + I + Y
Sbjct: 1260 IAESCVVEVDVTIVMKPKDGNEPIVYKEKAPYLLPPLEDLQSISIGGGNY 1309
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,495,712
Number of Sequences: 60738
Number of extensions: 4108410
Number of successful extensions: 9076
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 9013
Number of HSP's gapped (non-prelim): 26
length of query: 1617
length of database: 30,389,216
effective HSP length: 120
effective length of query: 1497
effective length of database: 23,100,656
effective search space: 34581682032
effective search space used: 34581682032
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)