ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV2313 good T KOG3417 Signal transduction mechanisms Ras1 guanine nucleotide exchange factor
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV2313 783852 788462 1537
(1537 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR310c [T] KOG3417 Ras1 guanine nucleotide exchange factor 755 0.0
SPCC1442.01 [T] KOG3417 Ras1 guanine nucleotide exchange factor 155 5e-37
SPBC336.03 [T] KOG3417 Ras1 guanine nucleotide exchange factor 151 7e-36
Hs15529996 [T] KOG3417 Ras1 guanine nucleotide exchange factor 149 4e-35
Hs20546742 [T] KOG3417 Ras1 guanine nucleotide exchange factor 122 6e-27
Hs19923151 [T] KOG3417 Ras1 guanine nucleotide exchange factor 119 3e-26
Hs4885357 [T] KOG3417 Ras1 guanine nucleotide exchange factor 109 4e-23
Hs7662070 [T] KOG3417 Ras1 guanine nucleotide exchange factor 106 3e-22
Hs8922307 [T] KOG3417 Ras1 guanine nucleotide exchange factor 105 6e-22
CE21520 [T] KOG3417 Ras1 guanine nucleotide exchange factor 103 2e-21
Hs22048159 [T] KOG3417 Ras1 guanine nucleotide exchange factor 100 2e-20
7302879 [T] KOG3417 Ras1 guanine nucleotide exchange factor 98 1e-19
7302878 [T] KOG3417 Ras1 guanine nucleotide exchange factor 98 1e-19
Hs22046650 [T] KOG3629 Guanine-nucleotide releasing factor 95 1e-18
Hs20127536 [T] KOG3629 Guanine-nucleotide releasing factor 94 1e-18
CE28081 [T] KOG3542 cAMP-regulated guanine nucleotide exchange f... 94 2e-18
CE28080 [T] KOG3542 cAMP-regulated guanine nucleotide exchange f... 94 2e-18
Hs7657261 [T] KOG3542 cAMP-regulated guanine nucleotide exchange... 92 5e-18
7290754 [T] KOG3417 Ras1 guanine nucleotide exchange factor 92 5e-18
CE28779 [T] KOG3417 Ras1 guanine nucleotide exchange factor 86 4e-16
Hs7706513 [T] KOG3542 cAMP-regulated guanine nucleotide exchange... 86 5e-16
7297097 [T] KOG3542 cAMP-regulated guanine nucleotide exchange f... 81 1e-14
Hs5901914 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 77 3e-13
Hs5032025 [T] KOG3417 Ras1 guanine nucleotide exchange factor 76 5e-13
Hs6912456 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 75 6e-13
7296574 [T] KOG3541 Predicted guanine nucleotide exchange factor 75 6e-13
Hs7662334 [T] KOG3417 Ras1 guanine nucleotide exchange factor 75 1e-12
CE05713 [T] KOG3417 Ras1 guanine nucleotide exchange factor 75 1e-12
7302302 [T] KOG2378 cAMP-regulated guanine nucleotide exchange f... 72 5e-12
Hs20149570 [T] KOG3417 Ras1 guanine nucleotide exchange factor 72 9e-12
7302774 [T] KOG3541 Predicted guanine nucleotide exchange factor 72 9e-12
7294445 [T] KOG3629 Guanine-nucleotide releasing factor 71 1e-11
Hs21687177 [T] KOG3541 Predicted guanine nucleotide exchange factor 71 2e-11
Hs20472756 [T] KOG3541 Predicted guanine nucleotide exchange factor 71 2e-11
CE07423 [T] KOG3541 Predicted guanine nucleotide exchange factor 71 2e-11
YAL024c [T] KOG3417 Ras1 guanine nucleotide exchange factor 68 1e-10
Hs7705939 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 68 1e-10
Hs20070215 [T] KOG2378 cAMP-regulated guanine nucleotide exchang... 68 1e-10
Hs4758532 [T] KOG3629 Guanine-nucleotide releasing factor 65 6e-10
YCR038c [T] KOG3417 Ras1 guanine nucleotide exchange factor 64 1e-09
CE28222 [T] KOG3629 Guanine-nucleotide releasing factor 62 5e-09
CE23992 [T] KOG2378 cAMP-regulated guanine nucleotide exchange f... 62 9e-09
>YLR310c [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1589
Score = 755 bits (1949), Expect = 0.0
Identities = 506/1568 (32%), Positives = 797/1568 (50%), Gaps = 149/1568 (9%)
Query: 12 PKAGLSTIIKPLDIVIAQYDFN-PLRKSQ----LRFFAGDIIYVISKSDSGWWDGILYYN 66
P T I+P+ IV+A YDFN P++K L G+ IY+++K+ SGWWDG++ +
Sbjct: 49 PSTSELTSIRPIGIVVAAYDFNYPIKKDSSSQLLSVQQGETIYILNKNSSGWWDGLVIDD 108
Query: 67 KS-LVLRGWFPRSYTKSIKDTSSSRKIFPLNYHGSNAFNNRPSSHGSRRNSLRIGSPSGN 125
+ V RGWFP+++ + ++D+ + P+ + S S SRR+SL S
Sbjct: 109 SNGKVNRGWFPQNFGRPLRDSHLRKHSHPMKKYSS--------SKSSRRSSLNSLGNSAY 160
Query: 126 MNI-RSTSGSRRGSLVSTGNFRRKSLGTTTFHDNHDNAINSGQTLLXXXXXXXXXXXXXX 184
+++ R+ S SRRGS + + T+ N+ ++N+
Sbjct: 161 LHVPRNPSKSRRGSSTLSASLSNAHNAETSSGHNNTVSMNNSPFSAPNDASHITPQSSNF 220
Query: 185 XXXXHLKQDYQFDMNRRSFSHSRSKPNATXXXXXXXXXXXXXXXXXXXXXXXKARSHSES 244
L QD M + + S NA +++E+
Sbjct: 221 NSNASLSQD----MTKSADGSSEMNTNAIM-------------------------NNNET 251
Query: 245 RNXXXXXXXXXXXXXXXPHTLHESEINILSTKEVEMLLNNMSRQEVVPVWTPV----LTT 300
P + E I IL +E+EM++N + R + W+P+ T+
Sbjct: 252 N-------LQTSGEKAGPPLVAEETIKILPLEEIEMIINGI-RSNIASTWSPIPLITKTS 303
Query: 301 SNNLLYFNKEMNIYCTSLPISRTPELSLKSV------FPPNENLVDLQARSLESDF-LPN 353
L+Y+NK+++IYC+ LP+ + + FPPN++LV+L R L + + +
Sbjct: 304 DYKLVYYNKDLDIYCSELPLISNSIMESDDICDSEPKFPPNDHLVNLYTRDLRKNANIED 363
Query: 354 TQVMDLESVISSQHRNLHDASPINPMVVISGNSSQKQPNTPSGPKPDLSQPCPSPGRSPS 413
+ +S +L + + NS N K + ++ PS S S
Sbjct: 364 SSTRSKQSESEQNRSSLLMEKQDSKETDGNNNSINDDDNNNENNKNEFNEAGPSSLNSLS 423
Query: 414 MHSNPTQSNEKNEEAGPKNSQPLAPKPLPQSNSRMFYSLSSDMKTWTELKNSTIYYLKAS 473
+ N ++ P S LA S +FY S D+K WTEL++ T+YY K +
Sbjct: 424 --APDLTQNIQSRVVAPSRSSILA-------KSDIFYHYSRDIKLWTELQDLTVYYTKTA 474
Query: 474 HNHFFKQNQPSFYQNFSKASTYIFYHQLACNLARKELIKRNVVKDXXXXXXXXXXXXFRI 533
H F K+N+ +F + F S I + QL C L + E+ ++ K+ RI
Sbjct: 475 HKMFLKENRLNFTKYFDLISDSIVFTQLGCRLMQHEIKAKSCSKEIKKIFKGLISSLSRI 534
Query: 534 NVNASVYFNSS-SKIVMNSSDIKKFNGDMLTSNRDTLNNGTRTSEAFVLPNNIEFPDLRN 592
++N+ +YF+S+ + M++ + K + +R ++G ++ ++ RN
Sbjct: 535 SINSHLYFDSAFHRKKMDTMNDKDNDNQENNCSRTEGDDGKIEVDSVHDLVSVPLSGKRN 594
Query: 593 VSTSTTTSFNP-NASLDSSHQGTMTSETIQISPDSPRASIPTNTTQTSNMLIDEETGIVL 651
VSTSTT + P +S + ++ M + ++ + P + S+ T T N +++ +
Sbjct: 595 VSTSTTDTLTPMRSSFSTVNENDMENFSV-LGPRNSVNSVVTPRTSIQNSTLEDFSPSNK 653
Query: 652 N-----SLFNVIHTDFTNIFKLVNNLHNIIIDSV-SPDDALVQIYPRFIRNSFEGIVWTK 705
N S++ ++ +F+ + V L+ ++ SV S D+ L Q+ PRF + SF G WT
Sbjct: 654 NFKSAKSIYEMVDVEFSKFLRHVQLLYFVLQSSVFSDDNTLPQLLPRFFKGSFSGGSWTN 713
Query: 706 SDPSFASKSEDSSDISNKSDQGNAXXXXXXXXXXXXXXXGRQYXXXXXRT-------VNS 758
+F + E + NK+ N + + NS
Sbjct: 714 PFSTFIT-DEFGNATKNKAVTSNEVTASSSKNSSISRIPPKMADAIASASGYSANSETNS 772
Query: 759 NLEKQNSSGSIGKI--------HNKLRARSKGSK-PARYPLNHTTLNLLRDKLSLISNIY 809
++ + SS + G + HN+ +R++ SK +YPL TLN ++ K S I
Sbjct: 773 QIDLKASSAASGSVFTPFNRPSHNRTFSRARVSKRKKKYPLTVDTLNTMKKKSSQIFEKL 832
Query: 810 KTDNSAILSSVDGGKL----VELSMGTYNGLKESAAFLNIIDKLDLQFFFNLKRCHSNEN 865
L + K +E++ TY + ++ L I++ LDL F NLK +
Sbjct: 833 NNATGEHLKIISKPKSRIRNLEINSSTYEQINQNVLLLEILENLDLSIFINLKNLIKTPS 892
Query: 866 --LEKEFHEFSESSMTNAVPILLEYYDLKQALHDITIRYVMDTQNLSLRDPFVFCSMRGE 923
L+ E EF +M++ +L E++D+KQA HDI IR +M TQ +L DP++F SMR
Sbjct: 893 ILLDLESEEFLVHAMSSVSSVLTEFFDIKQAFHDIVIRLIMTTQQTTLDDPYLFSSMR-- 950
Query: 924 LSQFSKGSHAELFQLV------------QEEKKSNSLYEHLVSQDVEINGMSFLDTQEVL 971
S F G H E F+ + + E+ + SL+ LVSQDVE N + FL+ +
Sbjct: 951 -SNFPVGHH-EPFKNISNTPLVKGPFHKKNEQLALSLFHVLVSQDVEFNNLEFLNNSDDF 1008
Query: 972 HEAATRYYNIATLISVIIEQLIVERENVINYAARMMNNDFMDVLLKDEQYEYDENLSSSV 1031
+A +Y I+ L +I++QLI EREN++NYAARMM N+ LLK EQ ++ + S
Sbjct: 1009 KDACEKYVEISNLACIIVDQLIEERENLLNYAARMMKNNLTAELLKGEQEKWFDIYSEDY 1068
Query: 1032 TISQTMSDDQETQQSSKASMFLSSTLDSKSPTFLQHSFVDE-LPWFLDSEHETELIYSPN 1090
+ DD E ++ + L S+ + + +++ LPWFL S++ET L+Y
Sbjct: 1069 S-----DDDSENDEA-----IIDDELGSEDYIERKAANIEKNLPWFLTSDYETSLVYDSR 1118
Query: 1091 GHIKGGTRLALIEHLTNHKSIDAFFNIVILTTFRSMFSTAEFLRYLFKRFDLSPPEGLSY 1150
G I+GGT+ ALIEHLT+H+ +DA FN+ +L TFRS+ +T EF L R++L PPEGLSY
Sbjct: 1119 GKIRGGTKEALIEHLTSHELVDAAFNVTMLITFRSILTTREFFYALIYRYNLYPPEGLSY 1178
Query: 1151 EEYNVWVDRKQKPIRIRVINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNMAILDEISGA 1210
++YN+W+++K PI+ RV+NI++ +LT YW YYE + + M + ++I GA
Sbjct: 1179 DDYNIWIEKKSNPIKCRVVNIMRTFLTQYWTRNYYEPG---IPLILNFAKMVVSEKIPGA 1235
Query: 1211 AELRPLVERKIAVNE-----LKLKRKDYEXXXXXXXXXALKNGL---------SKTSATF 1256
+L + K+ +NE + K++D K+ + S +SA F
Sbjct: 1236 EDLLQKINEKL-INENEKEPVDPKQQDSVSAVVQTTKRDNKSPIHMSSSSLPSSASSAFF 1294
Query: 1257 RLRKHKLTDFDPITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSS 1316
RL+K KL D DP T+A QLT+ EH LY I FECLDR WG K C+ GGS NI+ FI ++
Sbjct: 1295 RLKKLKLLDIDPYTYATQLTVLEHDLYLRITMFECLDRAWGTKYCNMGGSPNITKFIANA 1354
Query: 1317 NHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKK 1376
N LT+FVS+TIVK+ D+K R+++ Q+F+ V++ C L NFSSMTAIVSALYSSPI+RLKK
Sbjct: 1355 NTLTNFVSHTIVKQADVKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKK 1414
Query: 1377 TFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXX 1436
T+D + + L LN LMDS RNF +YR+LL++V DV CVPFFGVYLSDLTFT G
Sbjct: 1415 TWDLVSTESKDLLKNLNNLMDSKRNFVKYRELLRSVTDVACVPFFGVYLSDLTFTFVGNP 1474
Query: 1437 XXXXXXXXXXXXSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEAEMENILSIEKQYE 1496
SKR KI I+ EI+SF++ YKLK ++++ +EA +EN+ IEKQY+
Sbjct: 1475 DFLHNSTNIINFSKRTKIANIVEEIISFKRFHYKLKRLDDIQTVIEASLENVPHIEKQYQ 1534
Query: 1497 LSLKIEPR 1504
LSL++EPR
Sbjct: 1535 LSLQVEPR 1542
>SPCC1442.01 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 911
Score = 155 bits (392), Expect = 5e-37
Identities = 124/422 (29%), Positives = 188/422 (44%), Gaps = 24/422 (5%)
Query: 1090 NGHIKGGTRLALIEHLTNHKSIDAFFNIVILTTFRSMFSTAEFLRYLFKRF------DLS 1143
+G IK T + +I +L FF + L T+ SM S+++ L F +
Sbjct: 490 DGKIKTATLVFIINYLLRTDIDSTFFTTIFLNTYASMISSSDLFSILGAHFRFICSLNFG 549
Query: 1144 PPEGLSYEEYNVWVDRKQKPIRIRVINIIKAWLTDYW-NDCYYEDSQDSLDELNTVVNMA 1202
+S+E Y V R ++I+ W Y + S L ++ V +
Sbjct: 550 KISFISHEFYRV---------SKRFLDILLIWFESYLVEELDNSKSIFFLFKIYKVFEVF 600
Query: 1203 ILDEISGAAELRPLVERKIAVNELKLKRKDYEXXXXXXXXXALKNGLSKTSATFRLRKHK 1262
++ + A EL + + K K E L L + +
Sbjct: 601 VVPHFASAEELLHSLSHLLHHPSTKRSHKMLEGKELSQELEDLS--LHNSPDPIIYKDEL 658
Query: 1263 LTDFDPITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDF 1322
+ P A+QL + E +S I + + L +IW + F S F S NHL +F
Sbjct: 659 VLLLPPREIAKQLCILEFQSFSHISRIQFLTKIWDN-LNRFSPKEKTSTFYLS-NHLVNF 716
Query: 1323 VSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLP 1382
V+ TIV+E + ++R +L +FIQV + L NF+S+ +I+SAL SSPI RL+KT+ L
Sbjct: 717 VTETIVQEEEPRRRTNVLAYFIQVCDYLRELNNFASLFSIISALNSSPIHRLRKTWANLN 776
Query: 1383 KHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXX 1442
L S + LN L ++ +NF YRD L+ +PCVPF GVY +DLTF +G
Sbjct: 777 SKTLASFELLNNLTEARKNFSNYRDCLENC-VLPCVPFLGVYFTDLTFLKTG---NKDNF 832
Query: 1443 XXXXXXSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEAEMENILSIEKQYELSLKIE 1502
KR K+ ILNEI FQ + Y EV+ L + + Y+ SL +E
Sbjct: 833 QNMINFDKRTKVTRILNEIKKFQSVGYMFNPINEVQELLNEVISRERNTNNIYQRSLTVE 892
Query: 1503 PR 1504
PR
Sbjct: 893 PR 894
>SPBC336.03 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 987
Score = 151 bits (382), Expect = 7e-36
Identities = 136/549 (24%), Positives = 247/549 (44%), Gaps = 43/549 (7%)
Query: 967 TQEVLHEAATRYYNIATLISVIIEQLIVERENVINYAARMMNNDFMDV--LLKDEQYEY- 1023
+Q+++ E + + + T+I+ I ENV DF+ V L DE E
Sbjct: 469 SQDLMMEHSNDFSTMPTMIASIAVAFQTLFENVC---------DFLKVRAALVDEMQELA 519
Query: 1024 DENLSSSVTISQTMSDDQETQQSSKASMFLSSTLD-------SKSPTFLQHSFVDELPWF 1076
+ + + + T DD+ +Q++K + +S + D SK L + + +
Sbjct: 520 TKEFENKFSNANTAKDDEPARQTNKGTTRISRSSDFTAVSEMSKDTLTLGRNSLQSI-LM 578
Query: 1077 LDSEHETELIYSPNGHIKGGTRLALIEHLTNHKSIDAFFNIVILTTFRSMFSTAEFLRYL 1136
LD+ +++ S N ++KGGT AL+ +L + ++ F L T+++ + E L
Sbjct: 579 LDNLLTNKVVQSDN-NVKGGTLPALVHYLVQNVHLNKDFRHSFLLTYKTFTTPQELFTLL 637
Query: 1137 FKRFDLSPPEGLSYEEYNVWVDRKQKPIRIRVINIIKAWLTDYWNDCYYEDSQDSLDELN 1196
F PP GL Y+ W + V ++ W+ Y ++ED L N
Sbjct: 638 VILFHELPPPGLDATAYSSWEKGDNFVTKKNVCTVMNLWVQKY----FFED----LKARN 689
Query: 1197 TVVNMAILDEISGAAELRPLVERKIAVNELKLKRKDYEXXXXXXXXXALKNGLSKTSATF 1256
T+ ++ + LR V + + L D + LS ATF
Sbjct: 690 TLYLISEMRTF-----LRDHVVPSFHIGSVILSEID-NLWTEEPPDSLTQRLLSSPMATF 743
Query: 1257 RLRKHKLTDFDPITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSS 1316
+ + P FA Q+TL E I E + R W + + + N+I S
Sbjct: 744 I--SLNVYAYTPEEFASQMTLLEFDYLKQIPSREWIFRSWVSR----DSRSAVRNYINFS 797
Query: 1317 NHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKK 1376
N T ++ I+++ + K R ++ FFIQ + +C +L+NFS++ +IVSAL S+PI+RL
Sbjct: 798 NCFTYWIINCILEKKNTKARTAVISFFIQTAYKCLSLQNFSTLMSIVSALNSAPIYRLHA 857
Query: 1377 TFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXX 1436
+ + + L L ++++ +NF YR LL+ ++PCVPF GV LSDLTF G
Sbjct: 858 AYKLVKAEDIICLSGLREIVETKKNFSTYRALLRKA-ELPCVPFLGVILSDLTFIDEGNP 916
Query: 1437 XXXXXXXXXXXXSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEAEMENI-LSIEKQY 1495
+KR ++ ++ ++ FQ +Y+++ + +++ ++ + + +
Sbjct: 917 DVLDSSPHLLSFNKRHRLADVVADVCRFQSSSYEMQSNTDLQSYILHRCRFVNQDLSYLF 976
Query: 1496 ELSLKIEPR 1504
+ SL +EPR
Sbjct: 977 DKSLSLEPR 985
>Hs15529996 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1333
Score = 149 bits (375), Expect = 4e-35
Identities = 135/526 (25%), Positives = 235/526 (44%), Gaps = 55/526 (10%)
Query: 1013 DVLLKDEQYEYDENLSSSVTISQTMSDDQETQQSSKASMFLSSTLDSK-SPTFLQHSFVD 1071
+++LKDE +SV S ++++ ++ S+ STL+ T LQ +
Sbjct: 515 EIILKDE---------NSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEE 565
Query: 1072 ELPW-------FLDSEHETELIYSPNGH-------IKGGTRLALIEHLTNHKSIDAFFNI 1117
++ F + + E +I+ N IK GT + LIE LT H D F
Sbjct: 566 QMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVR 625
Query: 1118 VILTTFRSMFSTAEFLRYLFKRFDLSPPEGLSYEEYNVWVD-----------RKQ--KPI 1164
LTT+RS E L + +RF++ PE + + RK+ +P+
Sbjct: 626 TFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPV 685
Query: 1165 RIRVINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNMAILDEISGAAELRPLVERKIAVN 1224
++RV+N+ + W+ ++ D +E L + + + G A ++ VE +
Sbjct: 686 QLRVLNVCRHWVEHHFYD--FERDAYLLQRMEEFIGT-----VRGKA-MKKWVESITKII 737
Query: 1225 ELKLKRKDYEXXXXXXXXXALKNGLSKTSATFRLRKHKLTDFDPITFAQQLTLEEHILYS 1284
+ K +D + S + L PI A+QLTL E LY
Sbjct: 738 QRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYR 797
Query: 1285 AIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFI 1344
A+ E + +W K+ + S N+ I + +LT + IV+ +L++R ++ I
Sbjct: 798 AVQPSELVGSVWTKEDKEIN-SPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRII 856
Query: 1345 QVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFR 1404
++ + L NF+ + +VSA+ SSP++RL TF+++P L++ + L S ++ +
Sbjct: 857 EILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKK 914
Query: 1405 YRDLLKTVHDVPCVPFFGVYLSDLTFTASGX-XXXXXXXXXXXXXSKRLKIVMILNEIMS 1463
Y L++++ PCVPFFG+YL+++ T G SKR K+ I EI
Sbjct: 915 YLAKLRSINP-PCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQ 973
Query: 1464 FQKITYKLKHSEEVKLFLEAEMENILSIEKQ-----YELSLKIEPR 1504
+Q Y L+ ++K F E S+EK+ + SL+IEPR
Sbjct: 974 YQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPR 1019
>Hs20546742 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1237
Score = 122 bits (305), Expect = 6e-27
Identities = 96/345 (27%), Positives = 162/345 (46%), Gaps = 32/345 (9%)
Query: 1167 RVINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNMAIL---DEISGAAELRPLVERKIAV 1223
RV+N+++ W++ + D ELN + M +L +E+ +L P ERK A
Sbjct: 917 RVLNVLRHWVSKHAQDF----------ELNNELKMNVLNLLEEVLRDPDLLPQ-ERKAAA 965
Query: 1224 NELKLKRKDYEXXXXXXXXXALKNGLSKTSATFRLRKHKLTDFDPITFAQQLTLEEHILY 1283
N L+ +D + ++ T ++ + A+Q+TL +H+++
Sbjct: 966 NILRALSQDDQDDIHLKLEDIIQ-------MTDCMKAECFESLSAMELAEQITLLDHVIF 1018
Query: 1284 SAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDF---VSYTIVKETDLKKRAQIL 1340
+I E L + W K + + +S H D V+ I+ D+ RA +
Sbjct: 1019 RSIPYEEFLGQGWMK----LDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAI 1074
Query: 1341 QFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTR 1400
+ ++ V++ C L N++ + I SAL S I+RLKKT+ ++ K +DKL + S
Sbjct: 1075 EKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEG 1134
Query: 1401 NFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXSKRLKIVMILNE 1460
F R+ LK + P VP+ G+YL+DL F G SK I I+ E
Sbjct: 1135 RFKNLRETLKNCNP-PAVPYLGMYLTDLAFIEEG--TPNFTEEGLVNFSKMRMISHIIRE 1191
Query: 1461 IMSFQKITYKLKHSEEVKLFLEAEMENILSIEKQYELSLKIEPRV 1505
I FQ+ +Y++ H +V +L + + I+ + YELSLKIEPR+
Sbjct: 1192 IRQFQQTSYRIDHQPKVAQYL-LDKDLIIDEDTLYELSLKIEPRL 1235
>Hs19923151 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1275
Score = 119 bits (299), Expect = 3e-26
Identities = 91/339 (26%), Positives = 160/339 (46%), Gaps = 20/339 (5%)
Query: 1167 RVINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNMAILDEISGAAELRPLVERKIAVNEL 1226
RV+N+++ W++ + D ++ DEL V + L+E+ EL ERK A N +
Sbjct: 955 RVLNVLRHWVSKHSQDF------ETNDELKCKV-IGFLEEVMHDPELLTQ-ERKAAANII 1006
Query: 1227 KLKRKDYEXXXXXXXXXALKNGLSKTSATFRLRKHKLTDFDPITFAQQLTLEEHILYSAI 1286
+ ++ T ++ + + A+QLTL +H+++ I
Sbjct: 1007 RTLTQEDPGDNQITLEEI-------TQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKI 1059
Query: 1287 DQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQV 1346
E + W K+ + I N +++ ++ I++ D+ R ++ ++ V
Sbjct: 1060 PYEEFFGQGW-MKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAV 1118
Query: 1347 SEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYR 1406
++ C L N++++ I S++ S IFRLKKT+ ++ K +DKL L+ S F R
Sbjct: 1119 ADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLR 1178
Query: 1407 DLLKTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXSKRLKIVMILNEIMSFQK 1466
+ LK D PCVP+ G+YL+DL F G SK I I+ EI FQ+
Sbjct: 1179 EALKNC-DPPCVPYLGMYLTDLAFIEEG--TPNYTEDGLVNFSKMRMISHIIREIRQFQQ 1235
Query: 1467 ITYKLKHSEEVKLFLEAEMENILSIEKQYELSLKIEPRV 1505
YK++H +V +L + ++ E YE SL+IEP++
Sbjct: 1236 TAYKIEHQAKVTQYL-LDQSFVMDEESLYESSLRIEPKL 1273
>Hs4885357 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1077
Score = 109 bits (272), Expect = 4e-23
Identities = 124/455 (27%), Positives = 208/455 (45%), Gaps = 51/455 (11%)
Query: 1060 KSPTFLQHSF----VDELPWFLDSEHETELIYSPNGH----IKGGTRLALIEHLTNHKSI 1111
KSP L+ + VDEL +E + L G ++GG+ L+ H T
Sbjct: 651 KSPDALESAQSEEEVDELSLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDRK 710
Query: 1112 D-AFFNIVILTTFRSMFSTAEFLRYLFKRFDLSPPEGLSYEEYNVWVDRKQKPIRIRVIN 1170
D + LTT+R+ S E ++ L R++ P ++++ V + + +RV++
Sbjct: 711 DLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKR---VSKNTFFVLVRVVD 767
Query: 1171 IIKAWLTDYWNDCYYEDSQDSLDELNTVVNMAILD-EISGAAELRPLVERKIAVNELKLK 1229
+ C E +++ L L +V + + E+S A LR + K V++ KL
Sbjct: 768 EL----------CLVELTEEILKLLMELVFRLVCNGELSLARVLRKNILDK--VDQKKLL 815
Query: 1230 RKDYEXXXXXXXXXALKNGLSKTSATFRLRKHKLTDFDPITFAQQLTLEEHILYSAIDQF 1289
R A + G L DF A+QLTL + L+ I+
Sbjct: 816 RCATSSQPLAARGVAARPGT-------------LHDFHSHEIAEQLTLLDAELFYKIEIP 862
Query: 1290 ECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQ 1349
E L +W K+ + S N++ F N+++ +V I+ + + R ++L FI++ +
Sbjct: 863 EVL--LWAKEQNE-EKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKH 919
Query: 1350 CYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLL 1409
L NF+S AI+SAL S+PI RL+ K L + TL+DS+ +F YR L
Sbjct: 920 LRKLNNFNSYLAILSALDSAPIRRLE-----WQKQTSEGLAEYCTLIDSSSSFRAYRAAL 974
Query: 1410 KTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXSKRLKIVMILNEIMSFQKITY 1469
V + PC+P+ G+ L DLTF G SKR + IL+ + FQ+ Y
Sbjct: 975 SEV-EPPCIPYLGLILQDLTFVHLG---NPDYIDGKVNFSKRWQQFNILDSMRCFQQAHY 1030
Query: 1470 KLKHSEEVKLFLEAEMENILSIEKQYELSLKIEPR 1504
++ ++++ F + + L+ E +ELSLKI+PR
Sbjct: 1031 DMRRNDDIINFFN-DFSDHLAEEALWELSLKIKPR 1064
>Hs7662070 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 557
Score = 106 bits (265), Expect = 3e-22
Identities = 81/281 (28%), Positives = 134/281 (46%), Gaps = 29/281 (10%)
Query: 1268 PITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTI 1327
P FA Q+TL + ++ AI E W KK + N+ F N ++ +V I
Sbjct: 51 PEEFASQITLMDIPVFKAIQPEELASCGWSKKE-KHSLAPNVVAFTRRFNQVSFWVVREI 109
Query: 1328 VKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILN 1387
+ LK RA+IL F++++++ L N S+ ++VSAL S+PIFRL KT+ L +
Sbjct: 110 LTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKT 169
Query: 1388 SLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXXXXXXX 1447
+ +KL+ LM N+ R R+ ++++ VP +P+ G+YL DL + S
Sbjct: 170 TFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQR 229
Query: 1448 XSKRLKIVMILNEIM------------SFQKITYKLKHSEEVKLFLEAEMENILSIEKQY 1495
++ I+ I+ ++ QK +++ EE++ F+E + Y
Sbjct: 230 SNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVE---------DDNY 280
Query: 1496 ELSLKIEPRVDVSSSFNSAEYNTPTDLS--KAGSKKLRFGR 1534
+LSL+IEP +S E DL+ AGS RF R
Sbjct: 281 KLSLRIEPGSSSPRLVSSKE-----DLAGPSAGSGSARFSR 316
>Hs8922307 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 279
Score = 105 bits (262), Expect = 6e-22
Identities = 65/226 (28%), Positives = 112/226 (48%), Gaps = 12/226 (5%)
Query: 1268 PITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTI 1327
P +A Q+TL + ++ AI E W KK + + N F NH++ +V I
Sbjct: 50 PEEYAGQITLMDVPVFKAIQPDELSSCGWNKKE-KYSSAPNAVAFTRRFNHVSFWVVREI 108
Query: 1328 VKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILN 1387
+ LK RA++L +I+ +++ Y L N ++ A+VS L S+PIFRL KT+ L +
Sbjct: 109 LHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKT 168
Query: 1388 SLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXXXXXXX 1447
+ +KL +M N+ R RD + ++ PC+P+ G+YLSDLT+ S
Sbjct: 169 TFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENEQR 228
Query: 1448 XSKRLKIVMILNEIMS-----------FQKITYKLKHSEEVKLFLE 1482
+ I+ I++++ QK +++ EE++ F+E
Sbjct: 229 SNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVE 274
>CE21520 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 877
Score = 103 bits (258), Expect = 2e-21
Identities = 107/454 (23%), Positives = 196/454 (42%), Gaps = 74/454 (16%)
Query: 1065 LQHSFVDELPWFLDSEHETELIYSPNGHIKGGTRLALIEHLTNHKSIDAFFNIVILTTFR 1124
L+H VD + + E E +++ ++GG + ALI + T + L TFR
Sbjct: 474 LEHDGVD---YVIFREKEGKVL-----EVRGGPKDALIVYATQSTHSSLLYQEAFLITFR 525
Query: 1125 SMFSTAEFLRYLFKRF------DLSPPEGLSYEEYNVWV----DRKQKPIRIRVINIIKA 1174
+ S+ E + L KR+ D S E ++ ++V V + Q + +I + +
Sbjct: 526 TFISSLELVNKLIKRYLYMSLADDSQSESIARHTFSVIVRIIDETTQYELDFDLITSVTS 585
Query: 1175 WLTDYWNDCYYEDSQDSLDELNTVVNMAILDEISGAAELRPLVERKIAVNELKLKRKDYE 1234
++ Y D + ++ +LD I + +++ +
Sbjct: 586 FV--------YRLIHDGNFTYSRILRTRLLDRIKDSFDIQTV------------------ 619
Query: 1235 XXXXXXXXXALKNGLSKTSATFRLRKHKLTDFDPITFAQQLTLEEHILYSAIDQFECLDR 1294
L L K + H L DF A QLT + LY I+ E L
Sbjct: 620 ----------LGTNLCKPR-----KPHDLFDFKSAEIACQLTFIDSQLYHRIESAELL-- 662
Query: 1295 IWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLK 1354
W + + S N+ NF N+L+ +V I+ + K+R + + F+++ + +
Sbjct: 663 -WWAQEQNEKKSKNLVNFTEQFNNLSFWVRTLIITQGTQKERERHMMKFVKIMKHLREMC 721
Query: 1355 NFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHD 1414
NF+S AI+SA+ S+P+ RL+ + K+I ++L + +MD+ +++ YR LL+T
Sbjct: 722 NFNSYLAILSAIMSTPLARLEWS-----KNIKDALKEHTAVMDTAQSYKNYRALLQTAKP 776
Query: 1415 VPCVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXS-----KRLKIVMILNEIMSFQKITY 1469
PCVP+ G+ L DLTF +G + KR IL+ I +K Y
Sbjct: 777 -PCVPYIGIILQDLTFVHAGNPDTIPSDRCHGAKNMINFLKRWNQFAILDSIRKLKKWNY 835
Query: 1470 KLKHSEEVKLFLEAEMENILSIEKQYELSLKIEP 1503
+K ++ V + ++ + E+ ++LS +I+P
Sbjct: 836 DIKKNDIVVQYFNG-FKDCIDEERTWQLSHQIKP 868
>Hs22048159 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 558
Score = 100 bits (249), Expect = 2e-20
Identities = 75/243 (30%), Positives = 121/243 (48%), Gaps = 10/243 (4%)
Query: 1268 PITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTI 1327
PI A+QLTL E LY + E + +W K+ + S N+ I + +LT + I
Sbjct: 5 PIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEIN-SPNLLKMIRHTTNLTLWFEKCI 63
Query: 1328 VKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILN 1387
V+ + ++R +L I++ + +L NF+ + IVSA+ S ++RL TF+ L +
Sbjct: 64 VEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRK 123
Query: 1388 SLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASG-XXXXXXXXXXXX 1446
LD+ L S +F +Y LK+++ PCVPFFG+YL+++ T G
Sbjct: 124 ILDEAVEL--SQDHFKKYLVKLKSINP-PCVPFFGIYLTNILKTEEGNNDFLKKKGKDLI 180
Query: 1447 XXSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEAEMENILSIEKQ-----YELSLKI 1501
SKR K+ I EI +Q Y L+ +++ F E + EK+ + SL+I
Sbjct: 181 NFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEI 240
Query: 1502 EPR 1504
EPR
Sbjct: 241 EPR 243
>7302879 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 702
Score = 97.8 bits (242), Expect = 1e-19
Identities = 71/238 (29%), Positives = 122/238 (50%), Gaps = 13/238 (5%)
Query: 1272 AQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKET 1331
A Q+TL + +++ I E W KK + NI F NH + + I+
Sbjct: 171 ANQITLLDFPVFAQIQPDELSSCAWTKKDKHVN-TPNIVAFTKRFNHTSFWTVQEILNAE 229
Query: 1332 DLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDK 1391
K+RA+I+ FI+V+++ + L N S+ AI+SA+ S+ I+RL KT+ L K N+ D+
Sbjct: 230 QPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDR 289
Query: 1392 LNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXSKR 1451
L+ + N+ R L+++ +PC+P+ G++L+DL + +R
Sbjct: 290 LSDIFSDQDNWANLRSYLESLR-LPCIPYLGLFLTDLIY----IDLAHPHKGGLEPEQRR 344
Query: 1452 LKIVMILNEIMSFQKITYK-LKHSEEVKLFLEA-----EMENILSIEKQYELSLKIEP 1503
K+ IL I ++Q+ YK L+ E + +L + E++NI E QY+ SL +EP
Sbjct: 345 NKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFE-EDQYKRSLNLEP 401
>7302878 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 665
Score = 97.8 bits (242), Expect = 1e-19
Identities = 71/238 (29%), Positives = 122/238 (50%), Gaps = 13/238 (5%)
Query: 1272 AQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKET 1331
A Q+TL + +++ I E W KK + NI F NH + + I+
Sbjct: 171 ANQITLLDFPVFAQIQPDELSSCAWTKKDKHVN-TPNIVAFTKRFNHTSFWTVQEILNAE 229
Query: 1332 DLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDK 1391
K+RA+I+ FI+V+++ + L N S+ AI+SA+ S+ I+RL KT+ L K N+ D+
Sbjct: 230 QPKQRAEIITHFIKVAKKLHELNNLHSLFAIISAMQSASIYRLTKTWACLSKKDRNAFDR 289
Query: 1392 LNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXSKR 1451
L+ + N+ R L+++ +PC+P+ G++L+DL + +R
Sbjct: 290 LSDIFSDQDNWANLRSYLESLR-LPCIPYLGLFLTDLIY----IDLAHPHKGGLEPEQRR 344
Query: 1452 LKIVMILNEIMSFQKITYK-LKHSEEVKLFLEA-----EMENILSIEKQYELSLKIEP 1503
K+ IL I ++Q+ YK L+ E + +L + E++NI E QY+ SL +EP
Sbjct: 345 NKMNNILRVISNYQQSNYKHLQKHEATQKYLTSIRYIEELQNIFE-EDQYKRSLNLEP 401
>Hs22046650 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 1067
Score = 94.7 bits (234), Expect = 1e-18
Identities = 121/511 (23%), Positives = 198/511 (38%), Gaps = 96/511 (18%)
Query: 1093 IKGGTRLALIEHLTN-HKSIDAFFNIVILTTFRSMFSTAEFLRYLFKRFDLSPPEGLSYE 1151
+K GT L+EHL + D + + L T+R+ +T + L LFKR+ P
Sbjct: 323 VKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGCILP------ 376
Query: 1152 EYNVWVDRKQKPIRIRVINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNM---------- 1201
Y+ Q ++ + +I+ WL Y D L +L V +
Sbjct: 377 -YSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERR 435
Query: 1202 ------------AILDEISGAAELRPLVERKIAVNELKLKRKDYEXXXXXXXXXALK--- 1246
I E G + P +E + A + + E +L+
Sbjct: 436 AHLLLAQLEHSEPIEAEPEGEEDWAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSW 495
Query: 1247 -------NGLSKTSATFRLRKHKLTDFDPITFAQQLTLEEHILYSAIDQFECLDRIWGKK 1299
NGLS+ K L F P A+Q TL + L+ + + CL IW ++
Sbjct: 496 PSPVVAENGLSE-------EKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQR 548
Query: 1300 VCDFGGSANISNFI----TSSNHLTDFVSYTIV--KETDLKKRAQILQFFIQVSEQCYNL 1353
D G +++ I T N + + V T + + T RA++++ +I+V+ +C L
Sbjct: 549 --DKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRIL 606
Query: 1354 KNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLL---- 1409
KNFSS+ AI+SAL S+ I RLKKT++ + + KL+ + N+ R+LL
Sbjct: 607 KNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEG 666
Query: 1410 -----------KTVHDVP--------CVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXSK 1450
K P VP+ G +L+DL K
Sbjct: 667 TSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVML--DTAMKDYLYGRLINFEK 724
Query: 1451 RLKIVMILNEIMSFQKI--TYKLKHSEEVKLFLEAEMENILSIEKQYELSLKIEPRVDVS 1508
R K ++ +I Q Y + E+ + A LS + Y LS ++EP + +
Sbjct: 725 RRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVER--LSETESYNLSCELEPPSESA 782
Query: 1509 SSFNSAEYNT------------PTDLSKAGS 1527
S+ + NT T+LS +GS
Sbjct: 783 SNTLRTKKNTAIVKRWSDRQAPSTELSTSGS 813
>Hs20127536 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 803
Score = 94.4 bits (233), Expect = 1e-18
Identities = 109/454 (24%), Positives = 190/454 (41%), Gaps = 51/454 (11%)
Query: 1093 IKGGTRLALIEHL-TNHKSIDAFFNIVILTTFRSMFSTAEFLRYLFKRF-DLSPPEGLSY 1150
IK GT L+E+L T D + + L+T+R ST E L L R+ +L+ P
Sbjct: 104 IKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPN--CE 161
Query: 1151 EEYNVWVDRKQKPIRIRVINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNMAILDEISGA 1210
E+ + + IR + +I++AWL + C ++D + + +LD ++
Sbjct: 162 EDGSQSSSESKMVIRNAIASILRAWL----DQC----AEDFREPPHFPCLQKLLDYLT-- 211
Query: 1211 AELRPLVERKIAVNELKLKRKDYEXXXXXXXXXALKNGLSKTSATFRLRKHKLTDFDPIT 1270
+ P + + L + + E + L + + T F
Sbjct: 212 -RMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCFSEDL 270
Query: 1271 FAQQLTLEEHILYSAIDQFECLDRIWGK--KVCDFGGSANISNFITSSNHLTDFVSYTIV 1328
A+QLT + L+ + CL IW + K + + I I+ N LT V TI+
Sbjct: 271 VAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTIL 330
Query: 1329 --KETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHIL 1386
KE ++RA+I++ +I ++ +C LKNFSS+ AIVSAL S+ I+RLKKT+ +P+ +
Sbjct: 331 GGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDRM 390
Query: 1387 NSLDKLNTLMDSTRNFFRYRDLL--------------------KTVHDVP---------- 1416
++L+ + N R+LL +T +
Sbjct: 391 LMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQG 450
Query: 1417 CVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXSKRLKIVMILNEIMSFQKITYKLKHSEE 1476
VP+ G +L+DLT KR + ++ +I Q + +
Sbjct: 451 TVPYLGTFLTDLTML--DTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMTPD 508
Query: 1477 VKLFLEAEMENILSIEKQYELSLKIEPRVDVSSS 1510
K + + +L+ E+ Y LS +IE D S++
Sbjct: 509 QKFIQWFQRQQLLTEEESYALSCEIEAAADASTT 542
>CE28081 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1311
Score = 93.6 bits (231), Expect = 2e-18
Identities = 56/164 (34%), Positives = 94/164 (57%), Gaps = 3/164 (1%)
Query: 1272 AQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKET 1331
A QLTL++ ++SAI+ E LD ++ K+ GS + F N +V+ I E
Sbjct: 899 AAQLTLQDFSVFSAIEPTEFLDNLF--KLDSKYGSPKLEEFEQLFNREMWWVATEICTER 956
Query: 1332 DLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDK 1391
++KRA++++ FI+V+ C +L+NF+SM AI+S L + RL +++R+ + LD+
Sbjct: 957 HVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDE 1016
Query: 1392 LNTLMDSTRNFFRYRD-LLKTVHDVPCVPFFGVYLSDLTFTASG 1434
++ L+D +RN +YR L + + P VP + V DLTF G
Sbjct: 1017 IHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDG 1060
>CE28080 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1470
Score = 93.6 bits (231), Expect = 2e-18
Identities = 56/164 (34%), Positives = 94/164 (57%), Gaps = 3/164 (1%)
Query: 1272 AQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKET 1331
A QLTL++ ++SAI+ E LD ++ K+ GS + F N +V+ I E
Sbjct: 899 AAQLTLQDFSVFSAIEPTEFLDNLF--KLDSKYGSPKLEEFEQLFNREMWWVATEICTER 956
Query: 1332 DLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDK 1391
++KRA++++ FI+V+ C +L+NF+SM AI+S L + RL +++R+ + LD+
Sbjct: 957 HVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDE 1016
Query: 1392 LNTLMDSTRNFFRYRD-LLKTVHDVPCVPFFGVYLSDLTFTASG 1434
++ L+D +RN +YR L + + P VP + V DLTF G
Sbjct: 1017 IHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDG 1060
>Hs7657261 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1499
Score = 92.4 bits (228), Expect = 5e-18
Identities = 56/173 (32%), Positives = 92/173 (52%), Gaps = 3/173 (1%)
Query: 1263 LTDFDPITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDF 1322
L + A QL++ L+ I+ E +D ++ K+ AN+ F N T +
Sbjct: 713 LLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF--KLRSKTSCANLKRFEEVINQETFW 770
Query: 1323 VSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLP 1382
V+ I++ET+ KR +I++ FI+++ C KNF+SM AI+S L +P+ RL+ T+++LP
Sbjct: 771 VASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLP 830
Query: 1383 KHILNSLDKLNTLMDSTRNFFRYRDLLKTVH-DVPCVPFFGVYLSDLTFTASG 1434
L L D +RN +YR++L + + P +P F V DLTF G
Sbjct: 831 NKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEG 883
>7290754 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1380
Score = 92.4 bits (228), Expect = 5e-18
Identities = 106/421 (25%), Positives = 179/421 (42%), Gaps = 39/421 (9%)
Query: 1093 IKGGTRLALIEHLTN-HKSIDAFFNIVILTTFRSMFSTAEFLRYLFKRFDLSPPEGLSYE 1151
+KGG ALI H + K D F +TTFR+ + + L R+ +Y
Sbjct: 983 VKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRY--------TYF 1034
Query: 1152 EYNVWVDRKQKPIRIRVINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNMAILDEISGAA 1211
V D KQK + +++ ND D L L+ +V SG
Sbjct: 1035 FCQVQ-DNKQKAAKETFALLVRVV-----NDLTSTDLTSQL--LSLLVEFVYQLVCSGQL 1086
Query: 1212 ELRPLVERKIAVNELKLKR-KDYEXXXXXXXXXAL-------KNGLSKTSATFRLRKHKL 1263
L L+ K K K Y ++ G S T+ + L
Sbjct: 1087 YLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGSVGGAGIAGSGGCSGTAGGGN--QPSL 1144
Query: 1264 TDFDPITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFV 1323
D + A+Q+TL + L++ I+ E L ++ K C+ S N++ F N ++ +
Sbjct: 1145 LDLKSLEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCE-EKSPNLNKFTEHFNKMSYWA 1201
Query: 1324 SYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPK 1383
I++ D K+R + + FI++ + + N++S A++SAL S PI RL+ K
Sbjct: 1202 RSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE-----WQK 1256
Query: 1384 HILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXXX 1443
I + L+DS+ +F YR L + PC+P+ G+ L DLTF G
Sbjct: 1257 GITEEVRSFCALIDSSSSFRAYRQALAETNP-PCIPYIGLILQDLTFVHVG--NQDYLSK 1313
Query: 1444 XXXXXSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEAEMENILSIEKQYELSLKIEP 1503
SKR + I++ + F+K Y + +E + F + ++ + E+ +++S KI+P
Sbjct: 1314 GVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFD-NFKDFMGEEEMWQISEKIKP 1372
Query: 1504 R 1504
R
Sbjct: 1373 R 1373
>CE28779 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1349
Score = 86.3 bits (212), Expect = 4e-16
Identities = 116/503 (23%), Positives = 187/503 (37%), Gaps = 117/503 (23%)
Query: 1093 IKGGTRLALIEHLTNHKSIDA---FFNIVILTTFRSMFSTAEFLRYLFKRFDLSPPEGLS 1149
IK GT L LIE LT H D+ N + FR F
Sbjct: 657 IKCGTVLKLIERLTYHSYTDSNSSCINPLCEQKFRKEF---------------------- 694
Query: 1150 YEEYNVWVDRKQKPIRIRVINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNMAILDEISG 1209
Q+PI++RV+++I W+ +W D ++ LD L +N D G
Sbjct: 695 -----------QQPIQLRVLSVINQWVKLHWYD--FQCDPVLLDALELFLNRCC-DPREG 740
Query: 1210 AAE--------LRPLVERKI----AVNELKLKRKDYEXXXXXXXXXALKNG--------- 1248
++ + L+E+++ + + + D A G
Sbjct: 741 LSKQHKKFCKTILALIEKRVKNPPGIMQQPNENGDKGAADEGHVNSAFVFGDDQQHPPQH 800
Query: 1249 --------------LSKTSATFRLRKHKLTDFDPITFAQQLTLEEHILYSAIDQFECLDR 1294
L T+ + + L PI +QLTL LY AI E ++
Sbjct: 801 QVYTNESPKETNQVLWHTAQKGDVDHYDLLTLHPIEIGRQLTLLHSDLYRAIQPIELVEA 860
Query: 1295 IWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLK 1354
W K + S + S LT +VS +IV+ L++R + ++V L
Sbjct: 861 AWTKAE-KWRKSPQLLRLTDHSTLLTYWVSRSIVETESLEERMAMFNRVLEVMSVFEELH 919
Query: 1355 NFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHD 1414
NF+ + A SAL SS IFRLK +D L D+ NTL + R++++ K +
Sbjct: 920 NFTGLVAFYSALNSSCIFRLKWCWDGLDNEKKKCFDRFNTLCER-----RWQEMQKRLSS 974
Query: 1415 V--PCVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXS----------------------- 1449
+ PC+PFFG YLS++ F G
Sbjct: 975 INPPCIPFFGHYLSNIYFLEQGNSTFVNKSPPHGAAGAQKQQKDDLKASDPENSNKQFKQ 1034
Query: 1450 -----KRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEA-----EMENILSIEKQ-YELS 1498
K KI ++ EI FQ Y L ++ F E+ + ++ +E+ Y S
Sbjct: 1035 LVSFLKLRKISNVIREIQIFQDQRYSLTLEPTIRQFFESINPKNDFKSNEDLEEYLYNKS 1094
Query: 1499 LKIEPR-VDVSSSFNSAEYNTPT 1520
L+I+P+ +D ++ ++N T
Sbjct: 1095 LEIQPKGLDTPTAELKPKHNAST 1117
>Hs7706513 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1204
Score = 85.9 bits (211), Expect = 5e-16
Identities = 52/167 (31%), Positives = 90/167 (53%), Gaps = 3/167 (1%)
Query: 1269 ITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIV 1328
I A QL++ + L+ I+ E +D ++ K+ G+ ++ F N T +V+ I+
Sbjct: 912 IEVATQLSMRDFDLFRNIEPTEYIDDLF--KLNSKTGNTHLKRFEDIVNQETFWVASEIL 969
Query: 1329 KETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNS 1388
E + KR +I++ FI+++ C KNF+SM AI+S L + + RL+ T+++LP
Sbjct: 970 TEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKH 1029
Query: 1389 LDKLNTLMDSTRNFFRYRDLLKTVH-DVPCVPFFGVYLSDLTFTASG 1434
L L + D +RN +YR++L + P +P F V D+TF G
Sbjct: 1030 LQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEG 1076
>7297097 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1551
Score = 80.9 bits (198), Expect = 1e-14
Identities = 51/165 (30%), Positives = 88/165 (52%), Gaps = 4/165 (2%)
Query: 1272 AQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKET 1331
A QLTL++ + I+ E +D ++ ++ G +S F N +V I E
Sbjct: 873 AIQLTLQDFANFRQIESTEYVDELF--ELRSRYGVPMLSKFAELVNREMFWVVSEICAEH 930
Query: 1332 DLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDK 1391
++ +R +I++ FI+++ C +NF+SM AIVS L + RL++T+++LP +
Sbjct: 931 NIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFND 990
Query: 1392 LNTLMDSTRNFFRYRDLL--KTVHDVPCVPFFGVYLSDLTFTASG 1434
L LMD +RN +YR L+ + + P +PF+ + DLTF G
Sbjct: 991 LQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLG 1035
>Hs5901914 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 1011
Score = 76.6 bits (187), Expect = 3e-13
Identities = 53/183 (28%), Positives = 88/183 (47%), Gaps = 9/183 (4%)
Query: 1252 TSATFRLRKHKLTDFDPITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISN 1311
T TF L K A Q+T+ + L++ + + E + +G+ +AN+
Sbjct: 764 TVGTFELMSSK-------DLAYQMTIYDWELFNCVHELELIYHTFGRHNFK-KTTANLDL 815
Query: 1312 FITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPI 1371
F+ N + +V I + L KR Q+L+ FI+++ C KN +S AIV L + +
Sbjct: 816 FLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNIAV 875
Query: 1372 FRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFT 1431
RL T+++LP + +LMD +RN YR L + P +PF + + D+TFT
Sbjct: 876 SRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYR-LTVAKLEPPLIPFMPLLIKDMTFT 934
Query: 1432 ASG 1434
G
Sbjct: 935 HEG 937
>Hs5032025 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 797
Score = 75.9 bits (185), Expect = 5e-13
Identities = 81/388 (20%), Positives = 162/388 (40%), Gaps = 40/388 (10%)
Query: 1118 VILTTFRSMFSTAEFLRYLFKRFDLSPPEGLSYEEYNVWVDRKQKPIRIRVINIIKAWLT 1177
V+LT R + S+AE L+ + Y + + + +++ ++ W+T
Sbjct: 88 VMLTMHRIVISSAELLQKVITL-------------YKDALAKNSPGLCLKICYFVRYWIT 134
Query: 1178 DYWNDCYYEDS-QDSLDELNTVVNMAILDEISGAAELRPLVERKIAVNELKLKRKDYEXX 1236
++W + S D+++E +V + EL + +N RK
Sbjct: 135 EFWVMFKMDASLTDTMEEFQELVK-------AKGEELHCRLIDTTQINARDWSRK----- 182
Query: 1237 XXXXXXXALKNGLSKTSATFRLRKHKLTDFDPITFAQQLTLEEHILYSAIDQFECLDRIW 1296
+K+ SK L H +P ++ LT E + I + + +
Sbjct: 183 ----LTQRIKSNTSKKRKVSLLFDH----LEPEELSEHLTYLEFKSFRRISFSDYQNYLV 234
Query: 1297 GKKVCDFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNF 1356
V + + + I N ++ +V ++ + RA++ FIQV+++ + L+NF
Sbjct: 235 NSCVKE---NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNF 291
Query: 1357 SSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVP 1416
+++ A++ L S I RLK+T +P I L ++ L+ S+RN+ YR D
Sbjct: 292 NTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFK 351
Query: 1417 CVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXSKRLKIVMILNEIMSFQKITYKLKHSEE 1476
+P GV+L DL + K L + ++E++ Q++ L+ +++
Sbjct: 352 -IPILGVHLKDL--ISLYEAMPDYLGDGKVNVHKLLALYNHISELVQLQEVAPPLEANKD 408
Query: 1477 VKLFLEAEMENILSIEKQYELSLKIEPR 1504
+ L ++ + ++ YELS EPR
Sbjct: 409 LVHLLTLSLDLYYTEDEIYELSYAREPR 436
>Hs6912456 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 580
Score = 75.5 bits (184), Expect = 6e-13
Identities = 55/200 (27%), Positives = 95/200 (47%), Gaps = 2/200 (1%)
Query: 1306 SANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSA 1365
+AN+S + N + +V+ I+ + L KR Q+++ FI+++ C +N +S AIV
Sbjct: 383 TANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMG 442
Query: 1366 LYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYL 1425
L ++ + RL +T++++P +L +L D + N YRD K + P +PF + L
Sbjct: 443 LNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKP-PKIPFMPLLL 501
Query: 1426 SDLTFTASGXXXXXXXXXXXXXXSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEAEM 1485
D+TF G V L + Q K +E+K ++ +
Sbjct: 502 KDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVN-HL 560
Query: 1486 ENILSIEKQYELSLKIEPRV 1505
I S + +ELS +IEPRV
Sbjct: 561 YVIDSQQALFELSHRIEPRV 580
>7296574 [T] KOG3541 Predicted guanine nucleotide exchange factor
Length = 612
Score = 75.5 bits (184), Expect = 6e-13
Identities = 44/148 (29%), Positives = 78/148 (51%), Gaps = 13/148 (8%)
Query: 1297 GKKVCDFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNF 1356
G + D + N+ +++ N L+ + IVK K+R +I++++I+ + +C+N+ NF
Sbjct: 370 GGSLNDMKKTRNLESYVQWFNRLSYLTASEIVKYPKKKQRVRIIEYWIETARECFNIGNF 429
Query: 1357 SSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTV---- 1412
+S+ AI++ L +PI RLKKT+ ++ + L+ MD T NF YR LK
Sbjct: 430 NSLMAIIAGLNLAPIGRLKKTWAKVQSAKFSVLEH---QMDPTSNFNSYRSTLKAAMWRS 486
Query: 1413 ------HDVPCVPFFGVYLSDLTFTASG 1434
+ +PFF +++ DL F G
Sbjct: 487 EGATEERERIIIPFFSLFVKDLYFLNEG 514
>Hs7662334 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 689
Score = 74.7 bits (182), Expect = 1e-12
Identities = 64/266 (24%), Positives = 119/266 (44%), Gaps = 29/266 (10%)
Query: 1267 DPITFAQQLTLEEHILYSAIDQFE--------CLDRIWGKKVCDFGGSANISNFITSSNH 1318
+PI A+ LT EH + I + CL+ + + I N
Sbjct: 152 EPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLEN-----------NPTLERSIALFNG 200
Query: 1319 LTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTF 1378
++ +V ++ + ++RA+++ FI V+++ LKNF+++ A+V L S I RLK+T
Sbjct: 201 ISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETH 260
Query: 1379 DRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXXXX 1438
L + + +++ L+ S N+ YR D +P GV+L DL A
Sbjct: 261 SHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADC-DGFKIPILGVHLKDL--IAVHVIFP 317
Query: 1439 XXXXXXXXXXSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEAEMENILSIEKQYELS 1498
K ++ + L+E++S Q ++ L+ + ++ L ++ + + Y+LS
Sbjct: 318 DWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLS 377
Query: 1499 LKIEPRVDVSSSFNSAEYNTPTDLSK 1524
L +EPR NS +PT +K
Sbjct: 378 LVLEPR-------NSKSPTSPTTPNK 396
>CE05713 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 638
Score = 74.7 bits (182), Expect = 1e-12
Identities = 51/193 (26%), Positives = 96/193 (49%), Gaps = 3/193 (1%)
Query: 1313 ITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIF 1372
I+ N+L+++V I+ +T K+RA+IL F+ V++ + NF+++ ++V + S +
Sbjct: 225 ISVFNNLSNWVQCMILNKTTPKERAEILVKFVHVAKHLRKINNFNTLMSVVGGITHSSVA 284
Query: 1373 RLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTA 1432
RL KT+ L I L +L L+ + NF YR L + +P GV+L DL A
Sbjct: 285 RLAKTYAVLSNDIKKELTQLTNLLSAQHNFCEYRKALGACNKKFRIPIIGVHLKDL--VA 342
Query: 1433 SGXXXXXXXXXXXXXXSKRLKIVMILNEIMSFQKITYKL-KHSEEVKLFLEAEMENILSI 1491
K +K+ +L+ + F + + L + + ++ L+ ++ +
Sbjct: 343 INCSGANFEKTKCISSDKLVKLSKLLSNFLVFNQKGHNLPEMNMDLINTLKVSLDIRYND 402
Query: 1492 EKQYELSLKIEPR 1504
+ YELSL+ EP+
Sbjct: 403 DDIYELSLRREPK 415
>7302302 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 957
Score = 72.4 bits (176), Expect = 5e-12
Identities = 44/164 (26%), Positives = 84/164 (50%), Gaps = 4/164 (2%)
Query: 1272 AQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGG-SANISNFITSSNHLTDFVSYTIVKE 1330
A +TL E L+ A+ ++E L +G+ FG +AN+ F+ N + ++ +V
Sbjct: 723 AYHITLFEWDLFWAVHEYELLYHTFGRH--HFGKITANLDVFLRRFNEVQYWIVTELVST 780
Query: 1331 TDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLD 1390
L KR +++ FI+++ C +N ++ A+V L + + RL++T++++P
Sbjct: 781 PSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQ 840
Query: 1391 KLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASG 1434
+ L+D +RN YR + + P +PF + L D+TF G
Sbjct: 841 EFEALIDPSRNHRAYRVFVGKLQP-PLIPFMPLLLKDMTFAHEG 883
>Hs20149570 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 671
Score = 71.6 bits (174), Expect = 9e-12
Identities = 49/200 (24%), Positives = 92/200 (45%), Gaps = 9/200 (4%)
Query: 1309 ISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYS 1368
+ FI+ N ++ +V I+ + +RA ++ F+ V+E+ L+NF+++ A+V L
Sbjct: 255 LERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSH 314
Query: 1369 SPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCV----PFFGVY 1424
S I RLK+T + + + L L+ +T N+ YR L CV P GV+
Sbjct: 315 SSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRL-----AACVGFRFPILGVH 369
Query: 1425 LSDLTFTASGXXXXXXXXXXXXXXSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEAE 1484
L DL +K ++ IL E+ + ++ + ++ L
Sbjct: 370 LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVS 429
Query: 1485 MENILSIEKQYELSLKIEPR 1504
++ + ++ Y+LSL+ EPR
Sbjct: 430 LDQYQTEDELYQLSLQREPR 449
>7302774 [T] KOG3541 Predicted guanine nucleotide exchange factor
Length = 704
Score = 71.6 bits (174), Expect = 9e-12
Identities = 67/284 (23%), Positives = 124/284 (43%), Gaps = 28/284 (9%)
Query: 1168 VINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNMA-ILDEI---------SGAAELRPLV 1217
V+ ++ WL D +E L+ V +A LD I +G ++L L+
Sbjct: 334 VLRLLNEWLDTCPGDFSHELLLQELENKRNVKGLAAFLDGIPQALAQKDENGRSQLNNLL 393
Query: 1218 ERKIAVNELKLKRKDYEXXXXXXXXXALKNGLSKTSATFRLRKHKLTDFDPITFAQQLTL 1277
++ + + L + N L+ S+ F L H+L + + Q+ L
Sbjct: 394 TKQSSASSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELA-HQLYAIE-YAYLSQIRL 451
Query: 1278 EEHILYSAIDQFE-CLDRIW-GKKVCDFGGSANISNFITSSNHLTDFVSYTIVKETDLKK 1335
EE + D+ + C+ + G + I +++ N L+ + I+K +
Sbjct: 452 EEFVEILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQ 511
Query: 1336 RAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTL 1395
RAQ++ F+++ + +C+N NF+S+ AI++AL + I RLKKT+ ++ + L
Sbjct: 512 RAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQ---TTKFEGLEHQ 568
Query: 1396 MDSTRNFFRYRDLLKTV-----------HDVPCVPFFGVYLSDL 1428
MD + NF YR +K + +PFF ++L DL
Sbjct: 569 MDPSSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDL 612
>7294445 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 980
Score = 71.2 bits (173), Expect = 1e-11
Identities = 45/141 (31%), Positives = 75/141 (52%), Gaps = 3/141 (2%)
Query: 1271 FAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNH-LTDFVSYTIVK 1329
FA+QLT + L+ + +CL W ++ D GGS + I N L VS ++
Sbjct: 486 FAEQLTRMDTELFKRLIPHQCLGHTWARR--DSGGSETVVATINQFNAVLFRVVSSILID 543
Query: 1330 ETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSL 1389
++RA + +I ++++ LKNFSS+ AI+SAL S+ I+RL K ++ LPK +
Sbjct: 544 RLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVF 603
Query: 1390 DKLNTLMDSTRNFFRYRDLLK 1410
+L + N + R++LK
Sbjct: 604 TELANICSEDNNAWTLREVLK 624
>Hs21687177 [T] KOG3541 Predicted guanine nucleotide exchange factor
Length = 428
Score = 70.9 bits (172), Expect = 2e-11
Identities = 74/319 (23%), Positives = 127/319 (39%), Gaps = 41/319 (12%)
Query: 1144 PPEGLSYEEYNVWVDRKQ-----------KPIRIRVINIIKAWLTDYWNDCYYEDSQDSL 1192
PP L + V++KQ K +++ ++K W + D E + L
Sbjct: 29 PPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAEL 88
Query: 1193 DELNTVVNMAILDEISGAAELRPLVERKIAVNELKLKRKDYEXXXXXXXXXALKNGLSKT 1252
+ V DE +G + + + L + + E K + KT
Sbjct: 89 KAITHRVTQC--DEENGTVKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGPILKT 146
Query: 1253 SATFRLRKHKLTDFDPITFAQQLTLEE---------HILYSAIDQFECLD--RIWGKKVC 1301
+ DP+ AQQLT E L + + LD R G
Sbjct: 147 KPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRG---- 202
Query: 1302 DFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTA 1361
D + ++ + N L+ V+ + + K R ++L+FFI V+ +C+N+ NF+SM A
Sbjct: 203 DLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMA 262
Query: 1362 IVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLK----------T 1411
I+S + SP+ RLKKT+ ++ D L MD + NF YR L+ +
Sbjct: 263 IISGMNLSPVARLKKTWSKVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANS 319
Query: 1412 VHDVPCVPFFGVYLSDLTF 1430
+ +P F +++ D+ F
Sbjct: 320 SREKIVIPVFNLFVKDIYF 338
>Hs20472756 [T] KOG3541 Predicted guanine nucleotide exchange factor
Length = 428
Score = 70.9 bits (172), Expect = 2e-11
Identities = 74/319 (23%), Positives = 127/319 (39%), Gaps = 41/319 (12%)
Query: 1144 PPEGLSYEEYNVWVDRKQ-----------KPIRIRVINIIKAWLTDYWNDCYYEDSQDSL 1192
PP L + V++KQ K +++ ++K W + D E + L
Sbjct: 29 PPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAEL 88
Query: 1193 DELNTVVNMAILDEISGAAELRPLVERKIAVNELKLKRKDYEXXXXXXXXXALKNGLSKT 1252
+ V DE +G + + + L + + E K + KT
Sbjct: 89 KAITHRVTQC--DEENGTVKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGPILKT 146
Query: 1253 SATFRLRKHKLTDFDPITFAQQLTLEE---------HILYSAIDQFECLD--RIWGKKVC 1301
+ DP+ AQQLT E L + + LD R G
Sbjct: 147 KPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRG---- 202
Query: 1302 DFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTA 1361
D + ++ + N L+ V+ + + K R ++L+FFI V+ +C+N+ NF+SM A
Sbjct: 203 DLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMA 262
Query: 1362 IVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLK----------T 1411
I+S + SP+ RLKKT+ ++ D L MD + NF YR L+ +
Sbjct: 263 IISGMNLSPVARLKKTWSKVK---TAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANS 319
Query: 1412 VHDVPCVPFFGVYLSDLTF 1430
+ +P F +++ D+ F
Sbjct: 320 SREKIVIPVFNLFVKDIYF 338
>CE07423 [T] KOG3541 Predicted guanine nucleotide exchange factor
Length = 596
Score = 70.9 bits (172), Expect = 2e-11
Identities = 52/180 (28%), Positives = 85/180 (46%), Gaps = 21/180 (11%)
Query: 1267 DPITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSA--------NISNFITSSNH 1318
D T AQQLT E +S + E + + + + G + +IS +I N
Sbjct: 332 DAKTVAQQLTHIEMERFSMVGVDEIVQSLASDPLSEIGRHSKNKEGTISSISFYIEWFNR 391
Query: 1319 LTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTF 1378
L+ F + ++K+T + R + +F I ++++C + NF+SM AIV+ L + RLKKT+
Sbjct: 392 LSAFAAIEVLKQTKKRNRVAVFEFMIDIAKECCEIGNFNSMMAIVAGLSLPAVSRLKKTW 451
Query: 1379 DRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTV----------HDVPCVPFFGVYLSDL 1428
R+ K L+ L +D + NF YR +K +PFF + L DL
Sbjct: 452 CRVEK---AKLEILQHQLDPSGNFLSYRATIKAAQWRADSARGNQQKIVIPFFVLLLKDL 508
>YAL024c [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1435
Score = 67.8 bits (164), Expect = 1e-10
Identities = 50/178 (28%), Positives = 86/178 (48%), Gaps = 11/178 (6%)
Query: 1266 FDPITFAQQLTLEEHILYSAIDQFECLDR----------IWGKKVCDFGGSANISNFITS 1315
+D ++ AQQ+TL E + ID + LD W + + + I I+
Sbjct: 1193 YDSLSVAQQMTLIEKEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSGIDLAISR 1252
Query: 1316 SNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLK 1375
N D++ I+ K + ++Q FI V++ C +NF+++ I+ AL SS + +
Sbjct: 1253 FNLTVDWIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKFT 1312
Query: 1376 KTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHD-VPCVPFFGVYLSDLTFTA 1432
+ + L + ++L + RN+ R+LL +V+ V CVPF VYLSDL+ A
Sbjct: 1313 DAWRLIEPGDLLTWEELKKIPSLDRNYSTIRNLLNSVNPLVGCVPFIVVYLSDLSANA 1370
>Hs7705939 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 456
Score = 67.8 bits (164), Expect = 1e-10
Identities = 46/172 (26%), Positives = 85/172 (48%), Gaps = 10/172 (5%)
Query: 1267 DPITFAQQLTLEEHILYSAIDQFECLDRIW----GKKVCDFGGSANISNFITSSNHLTDF 1322
+P A LT L+ + + E +D ++ G++ +AN+ + + +T +
Sbjct: 218 EPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE-----TANLELLLQRCSEVTHW 272
Query: 1323 VSYTIVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLP 1382
V+ ++ KRAQ+L+ FI+++ C ++ S A+V L ++ + RL+ T+++LP
Sbjct: 273 VATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLP 332
Query: 1383 KHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASG 1434
N K L D RN YR+++ + P +PF + L DLTF G
Sbjct: 333 GKFKNLFRKFENLTDPCRNHKSYREVISKMKP-PVIPFVPLILKDLTFLHEG 383
>Hs20070215 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 881
Score = 67.8 bits (164), Expect = 1e-10
Identities = 49/163 (30%), Positives = 80/163 (49%), Gaps = 1/163 (0%)
Query: 1272 AQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKET 1331
A QLT + L+++I Q E + + G + +AN+ F+ N L +V+ +
Sbjct: 625 AGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCP 684
Query: 1332 DLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDK 1391
RAQ+L+ FI+++ KN +S A++ L +S I RL T++RLP +
Sbjct: 685 VPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSA 744
Query: 1392 LNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASG 1434
L L+D + N YR L + P +PF + L D+TF G
Sbjct: 745 LERLLDPSWNHRVYRLALAKL-SPPVIPFMPLLLKDMTFIHEG 786
>Hs4758532 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 777
Score = 65.5 bits (158), Expect = 6e-10
Identities = 66/273 (24%), Positives = 117/273 (42%), Gaps = 49/273 (17%)
Query: 1272 AQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSAN----ISNFITSSNHLTDFVSYTI 1327
A+QLTL + L+ + +CL +WG + D G ++ + +T N + V ++
Sbjct: 248 AEQLTLLDAELFLNLIPSQCLGGLWGHR--DRPGHSHLCPSVRATVTQFNKVAGAVVSSV 305
Query: 1328 VKETDL--------------KKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFR 1373
+ T +RA++L+ +I+V+E+C L+NFSS+ A+VSAL SSPI R
Sbjct: 306 LGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHR 365
Query: 1374 LKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLKTVHDVP----------------- 1416
L+ + + L L + N+ + R+LL V +V
Sbjct: 366 LRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELL--VQEVKLQSPLEPHSKKAPRSGS 423
Query: 1417 ----CVPFFGVYLSDLTFTASGXXXXXXXXXXXXXXSKRLKIVMILNEIMSFQKIT--YK 1470
VP+ G +L DL KR K +L+E+ Q Y
Sbjct: 424 RGGGVVPYLGTFLKDLVML--DAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYN 481
Query: 1471 LKHSEEVKLFLEAEMENILSIEKQYELSLKIEP 1503
L+ +++ +L+ L+ + + +S ++EP
Sbjct: 482 LQPDHDIQRWLQGLRP--LTEAQSHRVSCEVEP 512
>YCR038c [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 642
Score = 64.3 bits (155), Expect = 1e-09
Identities = 75/326 (23%), Positives = 129/326 (39%), Gaps = 72/326 (22%)
Query: 1148 LSYEEYNVWVDRKQKPIRIRVINIIKAWLTDYWNDC-----------------YYEDSQD 1190
LSY N K K V +I+ W+ YW D YYE +
Sbjct: 273 LSYPTIN-----KNKHKNHSVPRLIQIWVESYWQDSETTLKDILNFWYSHLAEYYEYQEL 327
Query: 1191 SLDELNTVVNMAILDEISGAAELRPLVERKIAVNELKLKRKDYEXXXXXXXXXALKNGLS 1250
D + +N ++ L +++I N+ L DYE L+ +
Sbjct: 328 FADIVQLFINKKRTRQLK--IHYIGLTDKEIEENKPPL---DYENLF-------LQYEID 375
Query: 1251 KTSAT-------------FRLRKHKLTDFD-------PITFAQQLTLEEHILYSAIDQFE 1290
KT+A F+ ++ +L + + P + A+ LTL E LY I+ E
Sbjct: 376 KTNANDELCGATDLSDLLFQWKQGELLEVEAFALNVSPWSLAKTLTLLESSLYLDIETIE 435
Query: 1291 CLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYTIVKETDLKKRAQILQFFIQVSEQC 1350
I + T SN L+ +V T +++T + +++QV+ C
Sbjct: 436 FTRHFKHN-------DTTIDSVFTLSNQLSSYVLETTLQQT------HTISYWLQVALSC 482
Query: 1351 YNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHILNSLDKLNTLMDSTRNFFRYRDLLK 1410
L+N +S+ +I+++L + I RL D H+ +L ++ N+ YR +K
Sbjct: 483 LYLRNLNSLASIITSLQNHSIERLSLPIDVKSDHL---FQRLKVVVHPNNNYNVYRRTIK 539
Query: 1411 TV--HDVPCVPFFGVYLSDLTFTASG 1434
+ +PCVPF + + D+TF G
Sbjct: 540 HIFHSQLPCVPFTSLLIRDITFIRDG 565
>CE28222 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 860
Score = 62.4 bits (150), Expect = 5e-09
Identities = 69/314 (21%), Positives = 133/314 (41%), Gaps = 23/314 (7%)
Query: 1093 IKGGTRLALIEHLTNHKSI--DAFFNIVILTTFRSMFSTAEFLRYLFKRFDLSPPEGLSY 1150
IK GT L+E L + FN V T+RS +A L L +R++
Sbjct: 68 IKAGTVERLVECLVGSDDMMDSRHFN-VFFATYRSFTDSAIVLDCLLRRYETL------- 119
Query: 1151 EEYNVWVDRKQKPIRIRVINIIKAWLTDYWNDCYYEDSQDSLDELNTVVNMAILDEISGA 1210
E V ++ + I+ WL Y D Y DS L+++++ ++++
Sbjct: 120 -ENEVNGSTSALLVQNSIRQIVMCWLETYPEDFY--DSDKDFAMLSSLLDFGGRNKLT-- 174
Query: 1211 AELRPLVERKIAVNELKLKRKDYEXXXXXXXXXALKNGLSKTSATFRLRKHKLTDFDP-- 1268
ELR ++ V + + G + + K ++ FD
Sbjct: 175 -ELRAKARKQREVFKRIYDEGGMQAALPSLGQYVADMGFDPSDYPNNI-KERVKMFDVGK 232
Query: 1269 ---ITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSY 1325
+ A+QLT + L+ + +C +W K+ + I N ++ V
Sbjct: 233 ENCVQIAEQLTFWDAALFKELLIHQCQGCVWSKRRTAGERVYTVKATIEQFNSVSQRVMT 292
Query: 1326 TIV-KETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKH 1384
+IV + + RA+I+ +I ++ + LKNFSS+ A++S+L S P+ RLK ++ +P
Sbjct: 293 SIVLPDCRPEYRAKIISKWIDIARELRALKNFSSLKAVLSSLQSEPVHRLKSAWNSVPNR 352
Query: 1385 ILNSLDKLNTLMDS 1398
++ +L+++ ++
Sbjct: 353 SISQFRELSSIYET 366
>CE23992 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 1234
Score = 61.6 bits (148), Expect = 9e-09
Identities = 62/243 (25%), Positives = 107/243 (43%), Gaps = 14/243 (5%)
Query: 1267 DPITFAQQLTLEEHILYSAIDQFECLDRIWGKKVCDFGGSANISNFITSSNHLTDFVSYT 1326
D A QL L L + D E L ++ G++ N+ + N + + +
Sbjct: 991 DSQELAHQLFLFHLQLLRSTDSNELLYQVIGRESFPLSMPFNLDLLVRRFNEVQHWSTTE 1050
Query: 1327 IVKETDLKKRAQILQFFIQVSEQCYNLKNFSSMTAIVSALYSSPIFRLKKTFDRLPKHIL 1386
I+ T+ + R +IL+ FI ++ ++ ++ AI L + I RL T+ +LP L
Sbjct: 1051 ILLATE-ENRMEILKKFISIATIAREYRDLLTVFAITLGLSHTSISRLTLTWSKLPPASL 1109
Query: 1387 NSLDKLNTLMDSTRNFFRYRDLLKTVHDVPCVPFFGVYLSDLTFTASGXXXXXXXXXXXX 1446
+ +L L+D TRN YR LL + P +PF + L DL F G
Sbjct: 1110 KTFSELENLLDPTRNHRMYR-LLVSKMSSPYIPFVPLILKDLMFIHQGNKSFYNGLVNFE 1168
Query: 1447 XXSKRLKIVMILNEIMSFQKITYKLKHSEEVKLFLEAE--MENILSIEKQ---YELSLKI 1501
K+ M SF++ ++ + E + F+E + + N+ I+ Q +LS +I
Sbjct: 1169 ------KMHMFAKIFRSFRQCKSQMDNGAEHE-FIEPQSLIRNLRVIDNQKKLMQLSYEI 1221
Query: 1502 EPR 1504
EP+
Sbjct: 1222 EPK 1224
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.131 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,540,729
Number of Sequences: 60738
Number of extensions: 3536655
Number of successful extensions: 14453
Number of sequences better than 1.0e-05: 42
Number of HSP's better than 0.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 14308
Number of HSP's gapped (non-prelim): 79
length of query: 1537
length of database: 30,389,216
effective HSP length: 120
effective length of query: 1417
effective length of database: 23,100,656
effective search space: 32733629552
effective search space used: 32733629552
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)