ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV2456 good O KOG2707 Posttranslational modification, protein turnover, chaperones Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV2456 836851 838020 390
(390 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDL104c [O] KOG2707 Predicted metalloprotease with chaperone act... 440 e-123
SPCC1259.10 [O] KOG2707 Predicted metalloprotease with chaperone... 234 1e-61
At2g45270 [O] KOG2707 Predicted metalloprotease with chaperone a... 146 6e-35
Hs11641265 [O] KOG2707 Predicted metalloprotease with chaperone ... 125 1e-28
7294127 [O] KOG2708 Predicted metalloprotease with chaperone act... 119 6e-27
CE20480 [O] KOG2707 Predicted metalloprotease with chaperone act... 115 1e-25
7293637 [O] KOG2707 Predicted metalloprotease with chaperone act... 115 1e-25
At4g22720 [O] KOG2708 Predicted metalloprotease with chaperone a... 111 2e-24
Hs8923380 [O] KOG2708 Predicted metalloprotease with chaperone a... 106 5e-23
YKR038c [O] KOG2708 Predicted metalloprotease with chaperone act... 105 1e-22
ECU09g0140 [O] KOG2708 Predicted metalloprotease with chaperone ... 105 1e-22
SPBC16D10.03 [O] KOG2708 Predicted metalloprotease with chaperon... 103 4e-22
CE27316 [O] KOG2708 Predicted metalloprotease with chaperone act... 82 2e-15
>YDL104c [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 407
Score = 440 bits (1131), Expect = e-123
Identities = 219/387 (56%), Positives = 284/387 (72%), Gaps = 13/387 (3%)
Query: 6 KSLPRSLVFRRAYRVLAIETSCDDTCVAILDRGTKDRPADVLCHLKSTLDSVEYGGVIPT 65
++ R + R+ Y+VLAIETSCDDTCV++LDR +K +VL +LK TLDS++ GG+IPT
Sbjct: 21 RAFNRPIQLRKGYKVLAIETSCDDTCVSVLDRFSKSAAPNVLANLKDTLDSIDEGGIIPT 80
Query: 66 RAHEHHQKNIASVVKSALKTTKSQNKIDLVCATRGPGMPGSLSVGLDVGKALSVAWDKPF 125
+AH HHQ I + + AL + ++ IDL+C TRGPGMPGSLS GLD K L+VAW+KP
Sbjct: 81 KAHIHHQARIGPLTERALIESNAREGIDLICVTRGPGMPGSLSGGLDFAKGLAVAWNKPL 140
Query: 126 IGVHHMLGHLLIPRLETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHEILCDTIDIAIGD 185
IGVHHMLGHLLIPR+ T+G PQ+PF++LLVSGGHT VLS +D HEILCDTIDIA+GD
Sbjct: 141 IGVHHMLGHLLIPRMGTNGKVPQFPFVSLLVSGGHTTFVLSRAIDDHEILCDTIDIAVGD 200
Query: 186 SLDKTARELGIKGNMIAKEMESFINEEDINVVRAGITSVKPMRLPTPLKNQNGRMNMQAF 245
SLDK RELG KG MIA+EME FIN +DIN + + +P+PLKN + NM +F
Sbjct: 201 SLDKCGRELGFKGTMIAREMEKFIN-QDINDQDFAL----KLEMPSPLKNSASKRNMLSF 255
Query: 246 SFSPFLTAVRQHLSQ----PIGEYTAEERRYMAYQVQESIFNHIITKLNLVLKLNSKRLS 301
SFS F+TA+R +L++ I E E R +AYQVQES+F+HII KL VLK ++
Sbjct: 256 SFSAFITALRTNLTKLGKTEIQELPEREIRSIAYQVQESVFDHIINKLKHVLKSQPEKFK 315
Query: 302 NVKHFVCSGGVGANMRLRHRLETDL----IRNFDSFHYPKLEYCTDNAVMIGWAGIELYE 357
NV+ FVCSGGV +N RLR +LET+L +F +F+YP ++ C+DN++MIGWAGIE++E
Sbjct: 316 NVREFVCSGGVSSNQRLRTKLETELGTLNSTSFFNFYYPPMDLCSDNSIMIGWAGIEIWE 375
Query: 358 SLGLTSDLSVTPIRKWPLTDILNVPGW 384
SL L SDL + PIR+WPL D+L+V GW
Sbjct: 376 SLRLVSDLDICPIRQWPLNDLLSVDGW 402
>SPCC1259.10 [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 412
Score = 234 bits (598), Expect = 1e-61
Identities = 154/402 (38%), Positives = 219/402 (54%), Gaps = 34/402 (8%)
Query: 2 FNCYKSLPRSLVFRRAYRVLAIETSCDDTCVAILDRGTKDRPA--DVLC-HLKSTLDSVE 58
F C+ ++ ++ + R LAIETSCDDT V+++ +++C + T+ E
Sbjct: 24 FRCW-NISKTFLSYRTLTALAIETSCDDTSVSVVRTSDSSSHCQNEIICLNTHRTISKYE 82
Query: 59 -YGGVIPTRAHEHHQKNIASVVKSALKTTKSQN--KIDLVCATRGPGMPGSLSVGLDVGK 115
YGG+ PT HQKN+A V++ + DL+ TRGPGM G L+VGL+ K
Sbjct: 83 AYGGIHPTIVIHEHQKNLAKVIQRTISDAARSGITDFDLIAVTRGPGMIGPLAVGLNTAK 142
Query: 116 ALSVAWDKPFIGVHHMLGHLLIPRLETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHEIL 175
L+V KP + VHHM H L +LE +P++ +LVSGGHTMLV S + HEI+
Sbjct: 143 GLAVGLQKPLLAVHHMQAHALAVQLEKS---IDFPYLNILVSGGHTMLVYSNSLLNHEII 199
Query: 176 CDTIDIAIGDSLDKTARELGI--KGNMIAKEMESFINEEDINVVRAGITSVKPMRLPTPL 233
T DIA+GD LDK A+ LGI M A +E F + E + + S+KP P PL
Sbjct: 200 VTTSDIAVGDYLDKCAKYLGIPWDNEMPAAALEQFASPE----INSTSYSLKP---PIPL 252
Query: 234 KNQNGRMNMQAFSFSPFLT-AVRQHLSQPIGEYTAEERRYMAYQVQESIFNHIITKLNLV 292
N +++ +FSFS + A R P+ E+++ AYQ+Q + F HI K L
Sbjct: 253 -NTREKVHSASFSFSGLESYACRIIRKTPL---NLSEKKFFAYQLQYAAFQHICQKTLLA 308
Query: 293 LKLNSKRLSNVKHFVCSGGVGANMRLRHRL-ETDLIRNFD------SFHYPKLEYCTDNA 345
LK LS VK+ VCSGGV N L+ L +T ++ F+ YP + C+DNA
Sbjct: 309 LK--RLDLSKVKYLVCSGGVARNELLKKMLNDTLMVLQFEHQPTDIKLVYPSPDICSDNA 366
Query: 346 VMIGWAGIELYESLGLTSDLSVTPIRKWPLTDILNVPGWIMK 387
MIG+ I+++++ G TS V PIRKWP+ IL V GW+ K
Sbjct: 367 AMIGYTAIQMFKA-GYTSSFDVEPIRKWPINQILTVEGWLTK 407
>At2g45270 [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 463
Score = 146 bits (368), Expect = 6e-35
Identities = 109/344 (31%), Positives = 163/344 (46%), Gaps = 42/344 (12%)
Query: 20 VLAIETSCDDTCVAILDRGTKDRPADVLCHLKSTLDS---VEYGGVIPTRAHEHHQKNIA 76
VL IETSCDDT A++ HL S+ + V+YGGV P +A E H + I
Sbjct: 86 VLGIETSCDDTAAAVVSPFN---------HLSSSCRAELLVQYGGVAPKQAEEAHSRVID 136
Query: 77 SVVKSAL-KTTKSQNKIDLVCATRGPGMPGSLSVGLDVGKALSVAWDKPFIGVHHMLGHL 135
VV+ AL K ++ + V T GPG+ L VG+ + ++ + P +GVHHM H
Sbjct: 137 KVVQDALDKANLTEKDLSAVAVTIGPGLSLCLRVGVRKARRVAGNFSLPIVGVHHMEAHA 196
Query: 136 LIPRLETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHEILCDTIDIAIGDSLDKTARELG 195
L+ RL L +PF+ LL+SGGH +LVL+ + ++ L T+D AIG++ DKTA+ LG
Sbjct: 197 LVARLVEQELS--FPFMALLISGGHNLLVLAHKLGQYTQLGTTVDDAIGEAFDKTAKWLG 254
Query: 196 IKGNMIAKEMESFINEEDINVVRAGITSVKPMRLPTPLKNQNGRMNMQ-----AFSFSPF 250
+++ R+G +V+ + L K+ + M+ FS++
Sbjct: 255 ------------------LDMHRSGGPAVEELALEGDAKSVKFNVPMKYHKDCNFSYAGL 296
Query: 251 LTAVRQHLSQPIGEYTAEERRYMAYQVQESIFNHIITKLNLVLKLNSKRLSNVKHFVCSG 310
T VR I R +A Q H+ K + + ++KH V SG
Sbjct: 297 KTQVR----LAIEAKEIRNRADIAASFQRVAVLHLEEKCERAIDWALELEPSIKHMVISG 352
Query: 311 GVGANMRLRHRLETDLIRNFDSFHYPKLEYCTDNAVMIGWAGIE 354
GV +N +R RL + P CTDN VM+ W G+E
Sbjct: 353 GVASNKYVRLRLNNIVENKNLKLVCPPPSLCTDNGVMVAWTGLE 396
>Hs11641265 [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 439
Score = 125 bits (314), Expect = 1e-28
Identities = 107/376 (28%), Positives = 165/376 (43%), Gaps = 38/376 (10%)
Query: 20 VLAIETSCDDTCVAILDRGTKDRPADVLCHL--KSTLDSVEYGGVIPTRAHEHHQKNIAS 77
VL IETSCDDT A++D +VL T ++ GG++P A + H++NI
Sbjct: 39 VLGIETSCDDTAAAVVDE-----TGNVLGEAIHSQTEVHLKTGGIVPPAAQQLHRENIQR 93
Query: 78 VVKSALKTTK-SQNKIDLVCATRGPGMPGSLSVGLDVGKALSVAWDKPFIGVHHMLGHLL 136
+V+ AL + S + + + T PG+ SL VGL L KPFI +HHM H L
Sbjct: 94 IVQEALSASGVSPSDLSAIATTIKPGLALSLGVGLSFSLQLVGQLKKPFIPIHHMEAHAL 153
Query: 137 IPRLETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHEILCDTIDIAIGDSLDKTARELGI 196
RL K ++PF+ LL+SGGH +L L V +L ++DIA GD LDK AR L +
Sbjct: 154 TIRLTN---KVEFPFLVLLISGGHCLLALVQGVSDFLLLGKSLDIAPGDMLDKVARRLSL 210
Query: 197 --------------------KGNMIAKEMESFINE-EDINVVRAGITSVKPMRLPTPLKN 235
+GN +++ ++ ++ + G+ V + K
Sbjct: 211 IKHPECSTMSGGKAIEHLAKQGNRFHFDIKPPLHHAKNCDFSFTGLQHVTDKIIMKKEKE 270
Query: 236 QNGRM--NMQAFSFSPFLTAVRQHLSQPIGEYTAEERRYMAYQVQESIFNHIITKLN--- 290
+ + ++ + + H + +A VQ ++ H++ + +
Sbjct: 271 EGIFLISKVEQINIPGLCLKIAAHFCRYEKGQILSSAADIAATVQHTMACHLVKRTHRAI 330
Query: 291 LVLKLNSKRLSNVKHFVCSGGVGANMRLRHRLETDLIRNFDSFHYPKLEYCTDNAVMIGW 350
L K N V SGGV +N +R LE + P CTDN +MI W
Sbjct: 331 LFCKQRDLLPQNNAVLVASGGVASNFYIRRALEILTNATQCTLLCPPPRLCTDNGIMIAW 390
Query: 351 AGIE-LYESLGLTSDL 365
GIE L LG+ D+
Sbjct: 391 NGIERLRGGLGILHDI 406
>7294127 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 347
Score = 119 bits (299), Expect = 6e-27
Identities = 97/353 (27%), Positives = 166/353 (46%), Gaps = 52/353 (14%)
Query: 21 LAIETSCDDTCVAILDRGTKDRPADVLCHLKSTLDSVEYGGVIPTRAHEHHQKNIASVVK 80
L IE S + + I+ R VL +++ T + G +P +HH++ I +V+
Sbjct: 5 LGIEGSANKIGIGII------RDGKVLANVRRTYITPPGEGFLPKETAKHHREAILGLVE 58
Query: 81 SALKTTKSQNK-IDLVCATRGPGMPGSLSVGLDVGKALSVAWDKPFIGVHHMLGHLLIPR 139
S+LK + ++ +D++C T+GPGM L VG V + LS+ W+ P +GV+H +GH+ + R
Sbjct: 59 SSLKEAQLKSSDLDVICYTKGPGMAPPLLVGAIVARTLSLLWNIPLLGVNHCIGHIEMGR 118
Query: 140 LETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHEILCDTIDIAIGDSLDKTAREL----- 194
L T P L VSGG+T ++ ++ ++ I +TIDIA+G+ LD+ AR +
Sbjct: 119 LITGAQNP----TVLYVSGGNTQVIAYSN-KRYRIFGETIDIAVGNCLDRFARIIKLSND 173
Query: 195 ---GIKGNMIAKEMESFIN----EEDINVVRAGITSVKPMRLPTPLKNQNGRMNMQAFSF 247
G +AK +I + ++V +GI S L P K QN R Q
Sbjct: 174 PSPGYNIEQLAKSSNRYIKLPYVVKGMDVSFSGILSYIE-DLAEPGKRQNKRKKPQ---- 228
Query: 248 SPFLTAVRQHLSQPIGEYTAEERRYMAYQVQESIFNHIITKLNLVLKLNSKRLSNV--KH 305
+ + Y+ + + Y +QE+IF +++++ + +++
Sbjct: 229 -----------EEEVNNYSQAD---LCYSLQETIF-------AMLVEITERAMAHCGSNE 267
Query: 306 FVCSGGVGANMRLRHRLETDLIRNFDSFHYPKLEYCTDNAVMIGWAGIELYES 358
+ GGVG N RL+ + YC DN +MI AG E++ S
Sbjct: 268 VLIVGGVGCNERLQEMMRIMCEERGGKLFATDERYCIDNGLMIAHAGAEMFRS 320
>CE20480 [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 421
Score = 115 bits (288), Expect = 1e-25
Identities = 98/365 (26%), Positives = 173/365 (46%), Gaps = 33/365 (9%)
Query: 3 NCYKSLPRSLVFRRAY------RVLAIETSCDDTCVAILDRGTKDRPADVLCHLKSTLDS 56
N K L +LV +R + +VL IETSCDDT VAI++ ++L + T +
Sbjct: 2 NIPKILNNNLVLKRIFCRNYSVKVLGIETSCDDTAVAIVNE-----KREILSSERYTERA 56
Query: 57 VE--YGGVIPTRAHEHHQKNIASVVKSALKTTKSQNK-IDLVCATRGPGMPGSLSVGLDV 113
++ GG+ P+ H++N+ +++ L + K +D V T PG+ +L G+
Sbjct: 57 IQRQQGGINPSVCALQHRENLPRLIEKCLNDAGTSPKDLDAVAVTVTPGLVIALKEGISA 116
Query: 114 GKALSVAWDKPFIGVHHMLGHLLIPRLETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHE 173
+ P I VHHM H L L D ++ +PF +L+SGGH ++ ++ DV+K +
Sbjct: 117 AIGFAKKHRLPLIPVHHMRAHALSILLVDDSVR--FPFSAVLLSGGHALISVAEDVEKFK 174
Query: 174 ILCDTIDIAIGDSLDKTARELGIKGNMIAKEMESFINEEDINVVRAGITSVKPMRLPTPL 233
+ ++ + G+ +DK AR+LG G+ E + + ++ + ++ +R P L
Sbjct: 175 LYGQSVSGSPGECIDKVARQLGDLGS----EFDGIHVGAAVEILASRASADGHLRYPIFL 230
Query: 234 KN-QNGRMNMQAF--SFSPFLTAVRQH--LSQPIGEYTAEERRYMAYQVQESIFNHIITK 288
N MN S+ L +R++ S I ++ A +Q ++ HI +K
Sbjct: 231 PNVPKANMNFDQIKGSYLNLLERLRKNSETSIDIPDFCA--------SLQNTVARHISSK 282
Query: 289 LNLVLKLNSKRLSNVKHFVCSGGVGANMRLRHRLETDLIRNFDSFHYPKLEYCTDNAVMI 348
L++ + S++ K V GGV AN + + + + L CTDNA MI
Sbjct: 283 LHIFFESLSEQEKLPKQLVIGGGVAANQYIFGAISKLSAAHNVTTIKVLLSLCTDNAEMI 342
Query: 349 GWAGI 353
++G+
Sbjct: 343 AYSGL 347
>7293637 [O] KOG2707 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 409
Score = 115 bits (287), Expect = 1e-25
Identities = 99/352 (28%), Positives = 153/352 (43%), Gaps = 23/352 (6%)
Query: 15 RRAYRVLAIETSCDDTCVAILDRGTKDRPADVLCHLKSTLDS--VEYGGVIPTRAHEHHQ 72
RR VL IETSCDDT +AI+D + V+ ++ + YGG+IP RA + H+
Sbjct: 22 RRLSYVLGIETSCDDTGIAIVDTTGR-----VIANVLESQQEFHTRYGGIIPPRAQDLHR 76
Query: 73 KNIASVVKSALKTTKSQ-NKIDLVCATRGPGMPGSLSVGLDVGKALSVAWDKPFIGVHHM 131
I S + ++ + + +++ + T PG+P SL VG+ + L+ KP + VHHM
Sbjct: 77 ARIESAYQRCMEAAQLKPDQLTAIAVTTRPGLPLSLLVGVRFARHLARRLQKPLLPVHHM 136
Query: 132 LGHLLIPRLETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHEILCDTIDIAIGDSLDKTA 191
H L R+E + YPF+ LL SGGH LV++ + +L T+D A G++ DK
Sbjct: 137 EAHALQARMEHPE-QIGYPFLCLLASGGHCQLVVANGPGRLTLLGQTLDDAPGEAFDKIG 195
Query: 192 RELGIKGNMIAKEMESFINEEDINVVRAGITSVKPMRLPTPLKNQN----GRMNMQAFSF 247
R L + I E + I + P PL Q ++ SF
Sbjct: 196 RRLRLH---ILPEYRLWNGGRAIEHAAQLASDPLAYEFPLPLAQQRNCNFSFAGIKNNSF 252
Query: 248 SPFLTAVRQHLSQPIGEYTAEERRYMAYQVQESIFNHIITKLNLVLK---LNSKRL--SN 302
R + P G + S+ H++ + ++ L ++L
Sbjct: 253 RAIRARERAERTPPDG--VISNYGDFCAGLLRSVSRHLMHRTQRAIEYCLLPHRQLFGDT 310
Query: 303 VKHFVCSGGVGANMRLRHRLETDLIRNFDSFHYPKLEYCTDNAVMIGWAGIE 354
V SGGV N + +E + P YC+DN VMI W G+E
Sbjct: 311 PPTLVMSGGVANNDAIYANIEHLAAQYGCRSFRPSKRYCSDNGVMIAWHGVE 362
>At4g22720 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 353
Score = 111 bits (278), Expect = 2e-24
Identities = 89/310 (28%), Positives = 140/310 (44%), Gaps = 61/310 (19%)
Query: 61 GVIPTRAHEHHQKNIASVVKSALKTTK-SQNKIDLVCATRGPGMPGSLSVGLDVGKALSV 119
G +P HH ++ +VKSAL+T++ + +ID +C T+GPGM L V V + LS
Sbjct: 43 GFLPRETAHHHLDHVLPLVKSALETSQVTPEEIDCICYTKGPGMGAPLQVSAIVVRVLSQ 102
Query: 120 AWDKPFIGVHHMLGHLLIPRLETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHEILCDTI 179
W KP + V+H + H+ + R+ T P + L VSGG+T ++ ++ ++ I +TI
Sbjct: 103 LWKKPIVAVNHCVAHIEMGRVVTGADDP----VVLYVSGGNTQVIAYSE-GRYRIFGETI 157
Query: 180 DIAIGDSLDKTAREL--------GIKGNMIAKEMESFINEEDINVVRAGITSVKPMRLPT 231
DIA+G+ LD+ AR L G +AK+ E+FI+ LP
Sbjct: 158 DIAVGNCLDRFARVLKLSNDPSPGYNIEQLAKKGENFID------------------LPY 199
Query: 232 PLKNQNGRMNMQAFSFSPFLTAVRQHLSQPIGEYTAEER--------RYMAYQVQESIFN 283
+K + SFS L+ + E TAEE+ + Y +QE++F
Sbjct: 200 AVKGMD-------VSFSGILSYI---------ETTAEEKLKNNECTPADLCYSLQETVFA 243
Query: 284 HIITKLNLVLKLNSKRLSNVKHFVCSGGVGANMRLRHRLETDLIRNFDSFHYPKLEYCTD 343
++ + K K + GGVG N RL+ + T YC D
Sbjct: 244 MLVEITERAMAHCDK-----KDVLIVGGVGCNERLQEMMRTMCSERDGKLFATDDRYCID 298
Query: 344 NAVMIGWAGI 353
N MI + G+
Sbjct: 299 NGAMIAYTGL 308
>Hs8923380 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 335
Score = 106 bits (265), Expect = 5e-23
Identities = 95/367 (25%), Positives = 168/367 (44%), Gaps = 44/367 (11%)
Query: 20 VLAIETSCDDTCVAILDRGTKDRPADVLCHLKSTLDSVEYGGVIPTRAHEHHQKNIASVV 79
VL E S + V ++ R VL + + T + G +P HH+ I ++
Sbjct: 4 VLGFEGSANKIGVGVV------RDGKVLANPRRTYVTPPGTGFLPGDTARHHRAVILDLL 57
Query: 80 KSAL-KTTKSQNKIDLVCATRGPGMPGSLSVGLDVGKALSVAWDKPFIGVHHMLGHLLIP 138
+ AL ++ + ID + T+GPGM L V + ++ W+KP +GV+H +GH+ +
Sbjct: 58 QEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEMG 117
Query: 139 RLETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHEILCDTIDIAIGDSLDKTARELGIKG 198
RL T P L VSGG+T ++ ++ ++ I +TIDIA+G+ LD+ AR L I
Sbjct: 118 RLITGATSP----TVLYVSGGNTQVIAYSE-HRYRIFGETIDIAVGNCLDRFARVLKISN 172
Query: 199 NMIAKEMESFINEEDINVVRAGITSVKPMRLPTPLKNQNGRMNMQAFSFSPFLTAVRQ-- 256
+ N+ + K + LP +K + SFS L+ +
Sbjct: 173 D----------PSPGYNIEQMAKRGKKLVELPYTVKGMD-------VSFSGILSFIEDVA 215
Query: 257 HLSQPIGEYTAEERRYMAYQVQESIFNHIITKLNLVLKLNSKRLSNV--KHFVCSGGVGA 314
H GE T E+ + + +QE++F +++++ + +++ + + GGVG
Sbjct: 216 HRMLATGECTPED---LCFSLQETVF-------AMLVEITERAMAHCGSQEALIVGGVGC 265
Query: 315 NMRLRHRLETDLIRNFDSFHYPKLEYCTDNAVMIGWAGIELYESLGLTSDLSVTPIRKWP 374
N+RL+ + T +C DN MI AG E++ + G + LS + + +
Sbjct: 266 NVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQAGWEMFRA-GHRTPLSDSGVTQRY 324
Query: 375 LTDILNV 381
TD + V
Sbjct: 325 RTDEVEV 331
>YKR038c [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 421
Score = 105 bits (262), Expect = 1e-22
Identities = 92/351 (26%), Positives = 163/351 (46%), Gaps = 35/351 (9%)
Query: 41 DRPADVLCHLKSTLDSVEYGGVIPTRAHEHHQKNIASVVKSALKTTKSQNK---IDLVCA 97
D A++L +++ T + G +P HH+ ++K AL ++ ID++C
Sbjct: 84 DCEAEMLSNIRDTYVTPPGEGFLPRDTARHHRNWCIRLIKQALAEADIKSPTLDIDVICF 143
Query: 98 TRGPGMPGSLSVGLDVGKALSVAWDKPFIGVHHMLGHLLIPRLETDGLKPQYPFITLLVS 157
T+GPGM L + + S+ WD P +GV+H +GH+ + R T P + L VS
Sbjct: 144 TKGPGMGAPLHSVVIAARTCSLLWDVPLVGVNHCIGHIEMGREITKAQNP----VVLYVS 199
Query: 158 GGHTMLVLSTDVDKHEILCDTIDIAIGDSLDKTARELGIKGNMIAKEMESFINEEDINVV 217
GG+T ++ ++ ++ I +T+DIAIG+ LD+ AR L I E N E +
Sbjct: 200 GGNTQVIAYSE-KRYRIFGETLDIAIGNCLDRFARTL-----KIPNEPSPGYNIEQL--A 251
Query: 218 RAGITSVKPMRLPTPLKNQNGRMNMQAFSFSPFLTA----VRQHLSQPIGEYTAEERRY- 272
+ + LP +K + ++M S L A ++ + + T E++
Sbjct: 252 KKAPHKENLVELPYTVKGMD--LSMSGILASIDLLAKDLFKGNKKNKILFDKTTGEQKVT 309
Query: 273 ---MAYQVQESIFNHIITKLNLVLKLNSKRLSNV--KHFVCSGGVGANMRLRHRL-ETDL 326
+ Y +QE++F +++++ + +++V + GGVG N+RL+ + +
Sbjct: 310 VEDLCYSLQENLF-------AMLVEITERAMAHVNSNQVLIVGGVGCNVRLQEMMAQMCK 362
Query: 327 IRNFDSFHYPKLEYCTDNAVMIGWAGIELYESLGLTSDLSVTPIRKWPLTD 377
R H +C DN VMI AG+ Y G+ D S T + + TD
Sbjct: 363 DRANGQVHATDNRFCIDNGVMIAQAGLLEYRMGGIVKDFSETVVTQKFRTD 413
>ECU09g0140 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 331
Score = 105 bits (262), Expect = 1e-22
Identities = 80/318 (25%), Positives = 148/318 (46%), Gaps = 33/318 (10%)
Query: 42 RPADVLCHLKSTLDSVEYGGVIPTRAHEHHQKNIASVVKSAL-KTTKSQNKIDLVCATRG 100
R ++L + + T G IP + EHH+ I +V +L K + +D+ C T+G
Sbjct: 19 RDDEILANERLTYAPPPGEGFIPVKTAEHHRSRILGLVAVSLEKAGVDLDDVDIFCYTKG 78
Query: 101 PGMPGSLSVGLDVGKALSVAWDKPFIGVHHMLGHLLIPRLETDGLKPQYPFITLLVSGGH 160
PGM LSV V + LS+ +KP + V+H + H+ + R T P + L SGG+
Sbjct: 79 PGMGLPLSVVATVARTLSLYCNKPLVPVNHCIAHIEMGRFITKASNP----VILYASGGN 134
Query: 161 TMLVLSTDVDKHEILCDTIDIAIGDSLDKTARELGIKGNMIAKEMESFINEEDINVVRAG 220
T ++ + +++I +T+DIA+G+ +D+ AR L + ++V R
Sbjct: 135 TQIIAYHN-RRYKIFGETLDIAVGNCIDRFARALKLPN----------FPAPGLSVERYA 183
Query: 221 ITSVKPMRLPTPLKNQNGRMNMQAFSFSPFLTAVRQHLSQPIGEYTAEERRYMAYQVQES 280
+ LP +K + SFS L+ +++ +++ + +R + Y +QE+
Sbjct: 184 KLGKNYIELPYVVKGMD-------VSFSGILSNIKRKIAE-----DEQVKRDLCYSLQET 231
Query: 281 IFNHIITKLNLVLKLNSKRLSNVKHFVCSGGVGANMRLRHRLETDLIRNFDSFHYPKLEY 340
+F+ ++ + +S K + GGVG N+RL+ + + +
Sbjct: 232 VFSALVEVTERAMAFSSS-----KEVLIVGGVGCNLRLQEMMGIMARERGGVCYATDERF 286
Query: 341 CTDNAVMIGWAGIELYES 358
C DN VMI + G+ + +S
Sbjct: 287 CIDNGVMIAYVGMLMAKS 304
>SPBC16D10.03 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 346
Score = 103 bits (257), Expect = 4e-22
Identities = 89/344 (25%), Positives = 164/344 (46%), Gaps = 37/344 (10%)
Query: 21 LAIETSCDDTCVAILDRGTKDRPADVLCHLKSTLDSVEYGGVIPTRAHEHHQKNIASVVK 80
L +E S + V I+ T A +L +++ T + G +P+ +HH+ I ++K
Sbjct: 8 LGLEGSANKLGVGIILHDTNGS-AKILANVRHTYITPPGQGFLPSDTAKHHRAWIIPLIK 66
Query: 81 SALKTTKSQNK-IDLVCATRGPGMPGSLSVGLDVGKALSVAWDKPFIGVHHMLGHLLIPR 139
A K K ID +C T+GPG+ L+ + LS+ KP + V+H +GH+ + R
Sbjct: 67 QAFAEAKISFKDIDCICFTKGPGIGAPLNSVALCARMLSLIHKKPLVAVNHCIGHIEMGR 126
Query: 140 LETDGLKPQYPFITLLVSGGHTMLVLSTDVDKHEILCDTIDIAIGDSLDKTARELGIKGN 199
T P + L VSGG+T ++ ++ K+ I +T+DIAIG+ LD+ AR +G+
Sbjct: 127 EITGAQNP----VVLYVSGGNTQVIAYSE-KKYRIFGETLDIAIGNCLDRFARIIGL--- 178
Query: 200 MIAKEMESFINEEDINVVRAGITSVKPMRLPTPLKNQNGRMNMQAFSFSPFLTAVRQHLS 259
S N+++ + + LP +K + SFS L+ V +
Sbjct: 179 -------SNAPSPGYNIMQEAKKGKRFIELPYTVKGMD-------CSFSGLLSGVEAAAT 224
Query: 260 QPIG--EYTAEERRYMAYQVQESIFNHIITKLNLVLKLNSKRLSNVK--HFVCSGGVGAN 315
+ + ++ ++ + Y +QE T +++++ + +++++ + GGVG N
Sbjct: 225 ELLDPKNPSSVTKQDLCYSLQE-------TGFAMLVEITERAMAHIRADSVLIVGGVGCN 277
Query: 316 MRLRHRL-ETDLIRNFDSFHYPKLEYCTDNAVMIGWAGIELYES 358
RL+ + E R D F + +C DN +MI AG+ Y++
Sbjct: 278 ERLQQMMAEMSSDRGADVFSTDE-RFCIDNGIMIAQAGLLAYKT 320
>CE27316 [O] KOG2708 Predicted metalloprotease with chaperone activity
(RNAse H/HSP70 fold)
Length = 258
Score = 81.6 bits (200), Expect = 2e-15
Identities = 53/147 (36%), Positives = 76/147 (51%), Gaps = 13/147 (8%)
Query: 20 VLAIETSCDDTCVAILDRGTKDRPADVLCHLKSTLDSVEYGGVIPTRAHEHHQKNIASVV 79
V+ IE S + V I+ G VL + ++T + G PT +HH++ I +V
Sbjct: 4 VIGIEGSANKIGVGIIRDGV------VLSNPRATFHAPPGEGFRPTETAQHHRQQIVRLV 57
Query: 80 KSALKTTKSQN---KIDLVCATRGPGMPGSLSVGLDVGKALSVAWDKPFIGVHHMLGHLL 136
A+K QN +ID + T+GPGM L VG V + LS+ W KP I V+H +GH+
Sbjct: 58 GEAIKLANIQNPELEIDGIAYTKGPGMGAPLQVGAIVARTLSLTWKKPIIPVNHCVGHIE 117
Query: 137 IPRLETDGLKPQYPFITLLVSGGHTML 163
+ RL T P + L VSGG+T L
Sbjct: 118 MGRLITGADNP----VVLYVSGGNTQL 140
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.138 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,023,790
Number of Sequences: 60738
Number of extensions: 961064
Number of successful extensions: 2287
Number of sequences better than 1.0e-05: 13
Number of HSP's better than 0.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 2231
Number of HSP's gapped (non-prelim): 16
length of query: 390
length of database: 30,389,216
effective HSP length: 108
effective length of query: 282
effective length of database: 23,829,512
effective search space: 6719922384
effective search space used: 6719922384
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)