ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV2609 good I KOG1393 Lipid transport and metabolism Hydroxymethylglutaryl-CoA synthase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV2609 Highly similar to YML126c SP|P54839 HMGS
3-hydroxy-3-methylglutaryl coenzyme A synthase singleton
(424 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YML126c [I] KOG1393 Hydroxymethylglutaryl-CoA synthase 716 0.0
SPAC4F8.14c [I] KOG1393 Hydroxymethylglutaryl-CoA synthase 502 e-142
Hs4504429 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase 414 e-115
7302938 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase 408 e-114
Hs5031751 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase 399 e-111
At4g11820 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase 375 e-104
CE09624 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase 276 5e-74
Hs17449881 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase 198 1e-50
ECU10g0510 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase 193 5e-49
Hs5729852 [R] KOG0286 G-protein beta subunit 34 0.36
Hs20336270 [R] KOG0286 G-protein beta subunit 34 0.36
Hs18591704 [R] KOG1721 FOG: Zn-finger 34 0.36
SPCC1529.01 [R] KOG0255 Synaptic vesicle transporter SVOP and re... 30 5.2
YIL031w [O] KOG0779 Protease Ulp1 family 30 6.8
SPAC14C4.15c [O] KOG2100 Dipeptidyl aminopeptidase 30 6.8
At4g22010 [Q] KOG1263 Multicopper oxidases 30 6.8
HsM4503845 [G] KOG0563 Glucose-6-phosphate 1-dehydrogenase 30 8.9
Hs6005701 [IR] KOG0059 Lipid exporter ABCA1 and related proteins... 30 8.9
Hs21614520 [G] KOG0563 Glucose-6-phosphate 1-dehydrogenase 30 8.9
At2g33150 [I] KOG1389 3-oxoacyl CoA thiolase 30 8.9
>YML126c [I] KOG1393 Hydroxymethylglutaryl-CoA synthase
Length = 491
Score = 716 bits (1849), Expect = 0.0
Identities = 340/424 (80%), Positives = 387/424 (91%)
Query: 1 MEKFDGVSSGKYTIGLGQTNMGFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTE 60
+EKFDGVS GKYTIGLGQTNM FVNDREDIYSMSLTVLSKL+K+YNIDTN +GR+EVGTE
Sbjct: 68 LEKFDGVSQGKYTIGLGQTNMSFVNDREDIYSMSLTVLSKLIKSYNIDTNKIGRLEVGTE 127
Query: 61 TLLDKSKSVKSVLTQLFPGNSDTEGIDTLNACYGGTNALFNSLNWIESSAWDGRDAIVVC 120
TL+DKSKSVKSVL QLF N+D EGIDTLNACYGGTNALFNSLNWIES+AWDGRDAIVVC
Sbjct: 128 TLIDKSKSVKSVLMQLFGENTDVEGIDTLNACYGGTNALFNSLNWIESNAWDGRDAIVVC 187
Query: 121 GDIAIYEKGAARPTGGAGTVALWIGPDAPIVFDPIRGSFMEHAYDFYKPDFTSEYPYVDG 180
GDIAIY+KGAARPTGGAGTVA+WIGPDAPIVFD +R S+MEHAYDFYKPDFTSEYPYVDG
Sbjct: 188 GDIAIYDKGAARPTGGAGTVAMWIGPDAPIVFDSVRASYMEHAYDFYKPDFTSEYPYVDG 247
Query: 181 HFSLTCYVKALDKAYEAYSKKAIAKGLAAKPAGNSAINVTEHFDYNVFHVPTCKLVTKSY 240
HFSLTCYVKALD+ Y++YSKKAI+KGL + PAG+ A+NV ++FDYNVFHVPTCKLVTKSY
Sbjct: 248 HFSLTCYVKALDQVYKSYSKKAISKGLVSDPAGSDALNVLKYFDYNVFHVPTCKLVTKSY 307
Query: 241 GRLLYNDFRANPSLYPEIDASLASVEYETSLTDKNLEKTFVNVAKPFHKERVAPSLIVPT 300
GRLLYNDFRANP L+PE+DA LA+ +Y+ SLTDKN+EKTFVNVAKPFHKERVA SLIVPT
Sbjct: 308 GRLLYNDFRANPQLFPEVDAELATRDYDESLTDKNIEKTFVNVAKPFHKERVAQSLIVPT 367
Query: 301 NTGNMYTASVYASLSSLLCYVGSDALQNKRIGLFSYGSGLAASLFSCKVVGDIKHIVDVL 360
NTGNMYTASVYA+ +SLL YVGSD LQ KR+GLFSYGSGLAASL+SCK+VGD++HI+ L
Sbjct: 368 NTGNMYTASVYAAFASLLNYVGSDDLQGKRVGLFSYGSGLAASLYSCKIVGDVQHIIKEL 427
Query: 361 DVENKLKSRKTESPEDYEKAILLREQAHLQKSFEPTGSIENLYPGTYYLTNVDDRYRRSY 420
D+ NKL R TE+P+DYE AI LRE AHL+K+F+P GSIE+L G YYLTN+DD++RRSY
Sbjct: 428 DITNKLAKRITETPKDYEAAIELRENAHLKKNFKPQGSIEHLQSGVYYLTNIDDKFRRSY 487
Query: 421 AIKE 424
+K+
Sbjct: 488 DVKK 491
>SPAC4F8.14c [I] KOG1393 Hydroxymethylglutaryl-CoA synthase
Length = 447
Score = 502 bits (1293), Expect = e-142
Identities = 253/427 (59%), Positives = 317/427 (73%), Gaps = 11/427 (2%)
Query: 1 MEKFDGVSSGKYTIGLGQTNMGFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTE 60
+E DGVS+GKYTIGLG T M FV+DREDIYS LT LS+L+K Y ID + +GR+EVGTE
Sbjct: 27 LEAHDGVSTGKYTIGLGLTKMAFVDDREDIYSFGLTALSQLIKRYQIDISKIGRLEVGTE 86
Query: 61 TLLDKSKSVKSVLTQLFPGNSDTEGIDTLNACYGGTNALFNSLNWIESSAWDGRDAIVVC 120
T++DKSKSVKSVL QLF N + EGID +NACYGG NALFN+++WIESSAWDGRD IVV
Sbjct: 87 TIIDKSKSVKSVLMQLFGDNHNVEGIDCVNACYGGVNALFNTIDWIESSAWDGRDGIVVA 146
Query: 121 GDIAIYEKGAARPTGGAGTVALWIGPDAPIVFDP-IRGSFMEHAYDFYKPDFTSEYPYVD 179
GDIA+Y KG ARPTGGAG VAL +GP+APIVF+P +RG++M+HAYDFYKPD TSEYPYVD
Sbjct: 147 GDIALYAKGNARPTGGAGCVALLVGPNAPIVFEPGLRGTYMQHAYDFYKPDLTSEYPYVD 206
Query: 180 GHFSLTCYVKALDKAYEAYSKKAIAKGLAAKPAGNSAINVTEHFDYNVFHVPTCKLVTKS 239
GHFSL CYVKALD AY Y+ + +AK ++ G + FDY +FH PTCK V K+
Sbjct: 207 GHFSLECYVKALDGAYANYNVRDVAKNGKSQGLG------LDRFDYCIFHAPTCKQVQKA 260
Query: 240 YGRLLYNDFRANPSLYPEIDA---SLASVEYETSLTDKNLEKTFVNVAKPFHKERVAPSL 296
Y RLLY D A PS PE++ L++++ + SLTDK LEK + + K +RV+PS+
Sbjct: 261 YARLLYTDSAAEPS-NPELEGVRELLSTLDAKKSLTDKALEKGLMAITKERFNKRVSPSV 319
Query: 297 IVPTNTGNMYTASVYASLSSLLCYVGSDALQNKRIGLFSYGSGLAASLFSCKVVGDIKHI 356
PTN GNMYTAS+++ L++LL V +D L+ KR+G +SYGSGLAAS FS V GD+ I
Sbjct: 320 YAPTNCGNMYTASIFSCLTALLSRVPADELKGKRVGAYSYGSGLAASFFSFVVKGDVSEI 379
Query: 357 VDVLDVENKLKSRKTESPEDYEKAILLREQAHLQKSFEPTGSIENLYPGTYYLTNVDDRY 416
++ N L +R +P YE+AI LR QAHL+K+F P GSIE L GTYYLT +DD +
Sbjct: 380 AKKTNLVNDLDNRHCLTPTQYEEAIELRHQAHLKKNFTPKGSIERLRSGTYYLTGIDDMF 439
Query: 417 RRSYAIK 423
RRSY++K
Sbjct: 440 RRSYSVK 446
>Hs4504429 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase
Length = 520
Score = 414 bits (1064), Expect = e-115
Identities = 215/436 (49%), Positives = 291/436 (66%), Gaps = 19/436 (4%)
Query: 1 MEKFDGVSSGKYTIGLGQTNMGFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTE 60
+EK+DGV +GKYTIGLGQ MGF DREDI S+ +TV+ L++ N+ + +GR+EVGTE
Sbjct: 36 LEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTE 95
Query: 61 TLLDKSKSVKSVLTQLFP--GNSDTEGIDTLNACYGGTNALFNSLNWIESSAWDGRDAIV 118
T++DKSKSVK+ L QLF GN+D EGIDT NACYGGT A+FN++NWIESS+WDGR A+V
Sbjct: 96 TIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALV 155
Query: 119 VCGDIAIYEKGAARPTGGAGTVALWIGPDAPIVFD-PIRGSFMEHAYDFYKPDFTSEYPY 177
V GDIA+Y G ARPTGG G VAL IGP+AP++F+ +RG+ M+HAYDFYKPD SEYP
Sbjct: 156 VAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPI 215
Query: 178 VDGHFSLTCYVKALDKAYEAYSKKAIAKGLAAKPAGNSAINVTEHFDYNVFHVPTCKLVT 237
VDG S+ CY+ ALD+ Y Y KK A+ + GN F + +FH P CKLV
Sbjct: 216 VDGKLSIQCYLSALDRCYSVYCKKIHAQW---QKEGNDKDFTLNDFGFMIFHSPYCKLVQ 272
Query: 238 KSYGRLLYNDF-----RANPSLYPEIDASLASVEYETSLTDKNLEKTFVNVAKPFHKERV 292
KS R+L NDF R S+Y ++A V+ E + D+++EK F+ + ++
Sbjct: 273 KSLARMLLNDFLNDQNRDKNSIYSGLEA-FGDVKLEDTYFDRDVEKAFMKASSELFSQKT 331
Query: 293 APSLIVPTNTGNMYTASVYASLSSLLCYVGSDALQNKRIGLFSYGSGLAASLFSCKVVGD 352
SL+V GNMYT+SVY SL+S+L L KRIG+FSYGSGLAA+L+S KV D
Sbjct: 332 KASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQD 391
Query: 353 I-------KHIVDVLDVENKLKSRKTESPEDYEKAILLREQAHLQKSFEPTGSIENLYPG 405
K + D++++L SR +P+ + + + LRE H ++ P GSI++L+ G
Sbjct: 392 ATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEG 451
Query: 406 TYYLTNVDDRYRRSYA 421
T+YL VD+++RR+YA
Sbjct: 452 TWYLVRVDEKHRRTYA 467
>7302938 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase
Length = 465
Score = 408 bits (1048), Expect = e-114
Identities = 219/434 (50%), Positives = 288/434 (65%), Gaps = 21/434 (4%)
Query: 1 MEKFDGVSSGKYTIGLGQTNMGFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTE 60
+E FDG S+GKYTIGLGQ MGF +DRED+ S+ LTV+S+LL+ ++ + +GR+EVGTE
Sbjct: 28 LETFDGASAGKYTIGLGQAKMGFCSDREDVNSLCLTVVSRLLERQHVKHSEIGRLEVGTE 87
Query: 61 TLLDKSKSVKSVLTQLFP--GNSDTEGIDTLNACYGGTNALFNSLNWIESSAWDGRDAIV 118
T++DKSKSVKSVL QLF GN+D EGIDT NACYGGT ALFN++NW+ESS+WDGR A+
Sbjct: 88 TIVDKSKSVKSVLMQLFAESGNTDIEGIDTTNACYGGTAALFNAVNWVESSSWDGRLALA 147
Query: 119 VCGDIAIYEKGAARPTGGAGTVALWIGPDAPIVFD-PIRGSFMEHAYDFYKPDFTSEYPY 177
VC DIA+Y KGAARPTGGAG VA+ +GP+AP++ D +R + MEHAYDFYKPD +SEYP
Sbjct: 148 VCADIAVYAKGAARPTGGAGAVAMLVGPNAPLILDRGLRATHMEHAYDFYKPDLSSEYPT 207
Query: 178 VDGHFSLTCYVKALDKAYEAYSKK--AIAKGLAAKPAGNSAINVTEHFDYNVFHVPTCKL 235
VDG S+ CY+ ALD Y Y KK K + +PA S FD +FH P CKL
Sbjct: 208 VDGKLSIQCYLSALDTCYRLYRKKFDQQQKDTSKQPASLST------FDAILFHTPFCKL 261
Query: 236 VTKSYGRLLYNDF-----RANPSLYPEIDASLASVEYETSLTDKNLEKTFVNVAKPFHKE 290
V KS GRL +NDF +P+++ + E++ D+++EK F+ +
Sbjct: 262 VQKSVGRLSFNDFLLSSEEERTKQFPDLE-RFNTATLESTYFDRDVEKAFMTQSANIFAS 320
Query: 291 RVAPSLIVPTNTGNMYTASVYASLSSLLCYVGSDALQNKRIGLFSYGSGLAASLFSCKVV 350
+ SL++ GNMYT SVY+ L SLL + L KRIGLFSYGSGLAAS++S V
Sbjct: 321 KTKKSLLLANQVGNMYTPSVYSGLVSLLISGPAQELVGKRIGLFSYGSGLAASMYSISVT 380
Query: 351 GD---IKHIVDVLD-VENKLKSRKTESPEDYEKAILLREQAHLQKSFEPTGSIENLYPGT 406
D + V LD V+ L SR+ +PE + + +RE+ + + PTGSI L+PGT
Sbjct: 381 QDAAAFEKFVSQLDYVQPLLNSREKVAPEQFSALMEVREKNNHAAPYTPTGSISALFPGT 440
Query: 407 YYLTNVDDRYRRSY 420
YYL +VD +RR+Y
Sbjct: 441 YYLKDVDALHRRTY 454
>Hs5031751 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase
Length = 508
Score = 399 bits (1026), Expect = e-111
Identities = 206/436 (47%), Positives = 291/436 (66%), Gaps = 19/436 (4%)
Query: 1 MEKFDGVSSGKYTIGLGQTNMGFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTE 60
+EK++ V +GKYT+GLGQT MGF + +EDI S+ LTV+ +L++ + ++VGR+EVGTE
Sbjct: 73 LEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVGTE 132
Query: 61 TLLDKSKSVKSVLTQLFP--GNSDTEGIDTLNACYGGTNALFNSLNWIESSAWDGRDAIV 118
T++DKSK+VK+VL +LF GN+D EGIDT NACYGGT +LFN+ NW+ESS+WDGR A+V
Sbjct: 133 TIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYAMV 192
Query: 119 VCGDIAIYEKGAARPTGGAGTVALWIGPDAPIVFD-PIRGSFMEHAYDFYKPDFTSEYPY 177
VCGDIA+Y G ARPTGGAG VA+ IGP AP+ + +RG+ ME+ YDFYKP+ SEYP
Sbjct: 193 VCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEYPI 252
Query: 178 VDGHFSLTCYVKALDKAYEAYSKKAIAKGLAAKPAGNSAINVTEHFDYNVFHVPTCKLVT 237
VDG S+ CY++ALD+ Y +Y KK + K AG+ + Y +FH P CK+V
Sbjct: 253 VDGKLSIQCYLRALDRCYTSYRKKIQNQW---KQAGSDRPFTLDDLQYMIFHTPFCKMVQ 309
Query: 238 KSYGRLLYNDFRA-----NPSLYPEIDASLASVEYETSLTDKNLEKTFVNVAKPFHKERV 292
KS RL++NDF + SLY ++A ++ E + T+K+L+K + ++ ++
Sbjct: 310 KSLARLMFNDFLSASSDTQTSLYKGLEA-FGGLKLEDTYTNKDLDKALLKASQDMFDKKT 368
Query: 293 APSLIVPTNTGNMYTASVYASLSSLLCYVGSDALQNKRIGLFSYGSGLAASLFSCKVVGD 352
SL + T+ GNMYT+S+Y L+SLL + + L RIG FSYGSGLAAS FS +V D
Sbjct: 369 KASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQD 428
Query: 353 I-------KHIVDVLDVENKLKSRKTESPEDYEKAILLREQAHLQKSFEPTGSIENLYPG 405
K + D+ +L SRK SPE++ + + REQ + + +F P G +L+PG
Sbjct: 429 AAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPG 488
Query: 406 TYYLTNVDDRYRRSYA 421
T+YL VD+++RR YA
Sbjct: 489 TWYLERVDEQHRRKYA 504
>At4g11820 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase
Length = 461
Score = 375 bits (962), Expect = e-104
Identities = 206/437 (47%), Positives = 273/437 (62%), Gaps = 23/437 (5%)
Query: 1 MEKFDGVSSGKYTIGLGQTNMGFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTE 60
+E DG S GKYTIGLGQ + F + ED+ SMS ++ L + Y ID N +GR+EVG+E
Sbjct: 24 LEAHDGASKGKYTIGLGQDCLAFCTELEDVISMSFNAVTSLFEKYKIDPNQIGRLEVGSE 83
Query: 61 TLLDKSKSVKSVLTQLFP--GNSDTEGIDTLNACYGGTNALFNSLNWIESSAWDGRDAIV 118
T++DKSKS+K+ L QLF GN+D EG+D+ NACYGGT AL N +NW+ES++WDGR +V
Sbjct: 84 TVIDKSKSIKTFLMQLFEKCGNTDVEGVDSTNACYGGTAALLNCVNWVESNSWDGRYGLV 143
Query: 119 VCGDIAIYEKGAARPTGGAGTVALWIGPDAPIVFD-PIRGSFMEHAYDFYKPDFTSEYPY 177
+C D A+Y +G ARPTGGA +A+ IGPDAPIVF+ +R S M H YDFYKP+ SEYP
Sbjct: 144 ICTDSAVYAEGPARPTGGAAAIAMLIGPDAPIVFESKLRASHMAHVYDFYKPNLASEYPV 203
Query: 178 VDGHFSLTCYVKALDKAYEAYSKKAIAKGLAAKPAGNSAINVTEHFDYNVFHVPTCKLVT 237
VDG S TCY+ ALD Y+ K K + + N A DY VFH P KLV
Sbjct: 204 VDGKLSQTCYLMALDSCYKHLCNK-FEKIEGKEFSINDA-------DYIVFHSPYNKLVQ 255
Query: 238 KSYGRLLYNDFRANPSLYPEID----ASLASVEYETSLTDKNLEKTFVNVAKPFHKERVA 293
KS+ RLLYNDF N S E +S+ + S ++LEK +AKPF+ +V
Sbjct: 256 KSFARLLYNDFLRNASSIDEAAKEKFTPYSSLTLDESYQSRDLEKVSQQIAKPFYDAKVQ 315
Query: 294 PSLIVPTNTGNMYTASVYASLSSLLCYVGSDALQNKRIGLFSYGSGLAASLFSCKVVGD- 352
P+ ++P GNMYTAS+YA+ +SL+ +D L KR+ +FSYGSG A++FS ++ +
Sbjct: 316 PTTLIPKEVGNMYTASLYAAFASLIHKKHND-LAGKRVVMFSYGSGSTATMFSLRLNDNK 374
Query: 353 ----IKHIVDVLDVENKLKSRKTESPEDYEKAILLREQAHLQKSFEPT--GSIENLYPGT 406
I +I V+DV KLK+R +PE + + + L E + K F T G I+ L PGT
Sbjct: 375 PPFSISNIASVMDVGGKLKARHEYAPEKFVETMKLMEHRYGAKDFVTTKEGIIDLLAPGT 434
Query: 407 YYLTNVDDRYRRSYAIK 423
YYL VD YRR Y K
Sbjct: 435 YYLKEVDSLYRRFYGKK 451
>CE09624 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase
Length = 462
Score = 276 bits (705), Expect = 5e-74
Identities = 169/433 (39%), Positives = 246/433 (56%), Gaps = 25/433 (5%)
Query: 1 MEKFDGVSSGKYTIGLGQTNMGFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTE 60
+EKF+ VSSGKYTIGLGQ MGF +D EDI S+SLTV KL++ Y I T+++G + VGTE
Sbjct: 33 LEKFNNVSSGKYTIGLGQQQMGFCSDNEDIVSISLTVTRKLIETYKISTDSIGCLVVGTE 92
Query: 61 TLLDKSKSVKSVLTQLFPGNSDTEGIDTLNACYGGTNALFNSLNWIE-SSAWDGRDAIVV 119
T++DKSKSVK+ L LFPGNSD EG+D NAC+GG AL ++++W+ + D ++AIVV
Sbjct: 93 TMIDKSKSVKTALMDLFPGNSDIEGVDIKNACFGGAQALLHAIDWVTVNHPLDKKNAIVV 152
Query: 120 CGDIAIYEKGAARPTGGAGTVALWIGPDAPIVFD-PIRGSFMEHAYDFYKP--DFTSEYP 176
DIAIYE+G AR TGGAG +A I PDA I D M++ +DF+KP SEYP
Sbjct: 153 VADIAIYEEGPARCTGGAGAIAFLICPDASIPIDRQFSACHMKNTWDFFKPITPIPSEYP 212
Query: 177 YVDGHFSLTCYVKALDKAYEAYSKKAIAKGLAAKPAGNSAINVTEHFDYNVFHVPTCKLV 236
VDG SL+ Y++A+ Y + K + I+ FD H P K+V
Sbjct: 213 VVDGSLSLSSYLEAVRMTYTYFISKV--------NRHTTGIDGLNSFDGVFLHSPFTKMV 264
Query: 237 TKSYGRLLYNDFRANPSLYPEIDASLASVEYETSLTDKNLEKTFVNVAKPFHKERVAPSL 296
K + Y D + + +++ + V+++ D+ + ++ KE+ P L
Sbjct: 265 QKGLAVMNYTDSQLR---HKQLNGN--GVDHKLDENDRAGLAKMIELSAQVWKEKTDPYL 319
Query: 297 IVPTNTGNMYTASVYASLSSLLCYVGSD--ALQNKRIGLFSYGSGLAASLFSCKV--VGD 352
+ GNMYT S++A LL Y+ +D K I F+YGSGLA+++F +V +
Sbjct: 320 VFNRRIGNMYTPSLFA---QLLAYLAADDCVTGEKSILFFAYGSGLASAIFPGRVRQTSN 376
Query: 353 IKHIVDV-LDVENKLKSRKTESPEDYEKAILLREQAHLQKSFEPTGSIENLYPGTYYLTN 411
+ I V + +L R +PE++ + + RE K + S +L+P TY+L N
Sbjct: 377 LDKIRQVAIRAIKRLDDRIQFTPEEFTETLQKREVFLRSKEIPKSPSETSLFPNTYFLDN 436
Query: 412 VDDRYRRSYAIKE 424
+D YRRSY + E
Sbjct: 437 MDKLYRRSYTLHE 449
>Hs17449881 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase
Length = 477
Score = 198 bits (504), Expect = 1e-50
Identities = 134/390 (34%), Positives = 193/390 (49%), Gaps = 69/390 (17%)
Query: 41 LLKNYNIDTNNVGRIEVGTETLLDKSKSVKSVLTQLFP--GNSDTEGIDTLNACYGGTNA 98
L++ N+ + GR+EVGTET+ DKSKSVK+ L QLF G+ D EG DT +ACYG A
Sbjct: 93 LMERKNLSYDCTGRLEVGTETIKDKSKSVKTNLMQLFEESGDIDIEGTDTTHACYGAPAA 152
Query: 99 LFNSLNWIESSAWDGRDAIVVCGDIAIYEKGAARPTGGAGTVALWIGPDAPIVFD-PIRG 157
+F+++NWIESS+WDG+ A+ GDIA+Y G R TG VAL I P+A ++F+ +RG
Sbjct: 153 VFSAVNWIESSSWDGQFALEFVGDIAVYPTGKVRLTGRVRAVALLIEPNATLIFERGLRG 212
Query: 158 SFMEHAYDFYKPDFTSEYPYVDGHFSLTCYVKALDKAYEAYSKKAIAKGLAAKPAGNSAI 217
+ M+ AY FY+PD SE P VDG S C ALD Y K A+ + GN
Sbjct: 213 THMQRAYGFYEPDMLSECPIVDGKPSTQCCFSALDHCYSVDCKTIRAQW---QKDGNDKD 269
Query: 218 NVTEHFDYNVFHVPTCKLVTKSYGRLLYNDFRANPSLYPEIDASLASVEYETSLTDKNLE 277
+F + + H P CKL TK+ LYP
Sbjct: 270 FTLNNFGFLILHSPYCKLKTKA------------SLLYP--------------------V 297
Query: 278 KTFVNVAKPFHKERVAPSLIVPTNTGNMYTASVYASLSSLLCYVGSDALQNKRIGLFSYG 337
K + + + R PS ++ + A+ + G+FSYG
Sbjct: 298 KMEIRTHRQYMVPRNCPSAVL------------------------TSAMIREETGVFSYG 333
Query: 338 SGLAASLFSCKVVGDI-------KHIVDVLDVENKLKSRKTESPEDYEKAILLREQAHLQ 390
SG AA+L+S KV D K + D++++ SR P+ + + + LRE H
Sbjct: 334 SGSAATLYSLKVPPDATPWSAVDKITASLWDLKSRCSSRTCVVPDVFVENMKLREDTHHL 393
Query: 391 KSFEPTGSIENLYPGTYYLTNVDDRYRRSY 420
+ P G ++L+ T+YL V +++RRSY
Sbjct: 394 VNSVPRGPRDSLFEETWYLAMVGEKHRRSY 423
>ECU10g0510 [I] KOG1393 Hydroxymethylglutaryl-CoA synthase
Length = 382
Score = 193 bits (490), Expect = 5e-49
Identities = 134/406 (33%), Positives = 200/406 (49%), Gaps = 75/406 (18%)
Query: 11 KYTIGLGQTNMGFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTETLLDKSKSVK 70
K IGLG MG + RED S++L +S+L+K YN+D +GR+EVGTE+ D SKS+K
Sbjct: 36 KIKIGLGLEQMGVPSRREDAISLALNAVSRLMKRYNVDPMAIGRLEVGTESNPDGSKSIK 95
Query: 71 SVLTQLFPGNSDTEGIDTLNACYGGTNALFNSLNWIESSAWDGRDAIVVCGDIAIYEKGA 130
S LT LFPGN+ G D ++ACY GTNAL +++ W+ESS WDGR AIVV D+A+Y+ +
Sbjct: 96 SYLTDLFPGNTSICGCDNVHACYSGTNALLSAIAWMESSFWDGRLAIVVASDVAMYKDKS 155
Query: 131 ARPTGGAGTVALWIGPDAPIVFDPIRGS---FMEHAYDFYKPDFTSEYPYVDGHFSLTCY 187
+PTGGAG VA+ +GP+ ++ + S + + +DF KP +P V G S+ Y
Sbjct: 156 CQPTGGAGAVAILLGPNC--IYRVVPSSVIHYFTNQFDFMKPRELHPFPVVKGKESIENY 213
Query: 188 VKALDKAYEAYSKKAIAKGLAAKPAGNSAINVTEHFDYNVFHVPTCKLVTKSYGRLLYND 247
A + Y + +K + FDY V H P +L K
Sbjct: 214 RTAFEICYGRFREKMAEE---------------SSFDYIVLHSPYTRLPEK--------- 249
Query: 248 FRANPSLYPEIDASLASVEYETSLTDKNLEKTFVNVAKPFHKERVAPSLIVPTNTGNMYT 307
+ +A ++++ SL GN Y+
Sbjct: 250 ---------------------------------ICIANHIDRKKLLRSLEASRRNGNAYS 276
Query: 308 ASVYASLSSLL-CYVGSDALQNKRIGLFSYGSGLAASLFSCKVVGDIKHIVDVLDVENKL 366
AS+Y SL SLL C+ D ++I +FSYGSG ++S+F + I V +L
Sbjct: 277 ASLYLSLISLLECH---DGEVGEKILMFSYGSGASSSMFCLE---RISKGCMVTGFRERL 330
Query: 367 KSRKTESPEDYEKAILLREQAHLQKSFEPTGSIENLYPGTYYLTNV 412
RK S +++ K + E+ Q ++E + E +Y YYL +
Sbjct: 331 LERKEISYQEFTKIL---EEPVPQDNYE---AQERIYSPGYYLKRI 370
>Hs5729852 [R] KOG0286 G-protein beta subunit
Length = 353
Score = 34.3 bits (77), Expect = 0.36
Identities = 41/158 (25%), Positives = 66/158 (40%), Gaps = 17/158 (10%)
Query: 60 ETLLDKSKSVKSVLTQLFPGNSDTEGIDTLNACYGGTNALFNSLNWIESSAWDGRDAIVV 119
E + K KSV L + + L A GT AL++ + ++ G A V+
Sbjct: 140 ENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVL 199
Query: 120 CGDIAIYEKGAARPTGGAGTVALWIGPDAPIVFDPIRGSFMEHAYDFYKPDFTS--EYP- 176
C D+A E G +GG A+ V+D G ++ A++ ++ D S YP
Sbjct: 200 CLDLAPSETGNTFVSGGCDKKAM--------VWDMRSGQCVQ-AFETHESDINSVRYYPS 250
Query: 177 ---YVDGHFSLTC--YVKALDKAYEAYSKKAIAKGLAA 209
+ G TC Y D+ YSK++I G ++
Sbjct: 251 GDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASS 288
>Hs20336270 [R] KOG0286 G-protein beta subunit
Length = 395
Score = 34.3 bits (77), Expect = 0.36
Identities = 41/158 (25%), Positives = 66/158 (40%), Gaps = 17/158 (10%)
Query: 60 ETLLDKSKSVKSVLTQLFPGNSDTEGIDTLNACYGGTNALFNSLNWIESSAWDGRDAIVV 119
E + K KSV L + + L A GT AL++ + ++ G A V+
Sbjct: 182 ENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVL 241
Query: 120 CGDIAIYEKGAARPTGGAGTVALWIGPDAPIVFDPIRGSFMEHAYDFYKPDFTS--EYP- 176
C D+A E G +GG A+ V+D G ++ A++ ++ D S YP
Sbjct: 242 CLDLAPSETGNTFVSGGCDKKAM--------VWDMRSGQCVQ-AFETHESDINSVRYYPS 292
Query: 177 ---YVDGHFSLTC--YVKALDKAYEAYSKKAIAKGLAA 209
+ G TC Y D+ YSK++I G ++
Sbjct: 293 GDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASS 330
>Hs18591704 [R] KOG1721 FOG: Zn-finger
Length = 851
Score = 34.3 bits (77), Expect = 0.36
Identities = 29/77 (37%), Positives = 35/77 (44%), Gaps = 5/77 (6%)
Query: 131 ARPTGGAGTVALWIGPDAPIVFDPIRGSFMEHAYDFYKPD-FTSEYPYVDGHFSLTCYVK 189
+RP+GG + GP +P DP R +H P FT E P + G F L VK
Sbjct: 352 SRPSGGMEALKA-AGPASPPEEDPER---TKHRRKQKTPKKFTGEQPSISGTFGLKGLVK 407
Query: 190 ALDKAYEAYSKKAIAKG 206
A DKA SKK G
Sbjct: 408 AEDKARVHRSKKQEGPG 424
>SPCC1529.01 [R] KOG0255 Synaptic vesicle transporter SVOP and related
transporters (major facilitator superfamily)
Length = 462
Score = 30.4 bits (67), Expect = 5.2
Identities = 36/129 (27%), Positives = 55/129 (41%), Gaps = 23/129 (17%)
Query: 129 GAARPTG-GAGTVALWIGPD-----------APIV---FDPIRGSFMEHAYDFYKPDFTS 173
G+A P G G+GT++ PD AP++ P+ F+ Y YK F S
Sbjct: 148 GSATPMGLGSGTISDLFTPDERGKAVAVMSLAPLLGPTIGPVVSGFIAE-YTTYKWIFWS 206
Query: 174 EYPYVDGHFSLTCYVKALDKAYEAYSKKAIAKGLAAKPAGNSAINVTEHFDYNVFHVPTC 233
+ F+L+ + A E Y K + G A+ S H ++N+ H+P
Sbjct: 207 TTIFSGFIFALSLPLLA-----ETYPKTLL--GEKARKLNKSEKTNKYHTEWNLEHIPRL 259
Query: 234 KLVTKSYGR 242
KLVT + R
Sbjct: 260 KLVTPALMR 268
>YIL031w [O] KOG0779 Protease Ulp1 family
Length = 1034
Score = 30.0 bits (66), Expect = 6.8
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 7/50 (14%)
Query: 378 EKAILLREQAHLQKSFEPTGSIENLYPGTYY-----LTNVDDRYRRSYAI 422
EK+I+ REQ HL SF T I N P YY N D + + Y +
Sbjct: 476 EKSIIKREQVHLMSSFFYTKLISN--PADYYSNVKKWVNNTDLFSKKYVV 523
>SPAC14C4.15c [O] KOG2100 Dipeptidyl aminopeptidase
Length = 743
Score = 30.0 bits (66), Expect = 6.8
Identities = 21/64 (32%), Positives = 33/64 (50%), Gaps = 7/64 (10%)
Query: 351 GDIKHIVDVLDVENKLKSRKT--ESPEDYEKAILLREQAHLQK-SFEPTGSIENLYPGTY 407
G+ + + + D L SRKT E+ E E + L HL+ SFE G+++ Y Y
Sbjct: 282 GNYERVTSLFD----LSSRKTTIENTEVSEHPLALTSSLHLKYLSFESLGNLKERYVRQY 337
Query: 408 YLTN 411
+L+N
Sbjct: 338 FLSN 341
>At4g22010 [Q] KOG1263 Multicopper oxidases
Length = 541
Score = 30.0 bits (66), Expect = 6.8
Identities = 13/37 (35%), Positives = 18/37 (48%)
Query: 132 RPTGGAGTVALWIGPDAPIVFDPIRGSFMEHAYDFYK 168
+ G G + +W P P+ F P G F A D+YK
Sbjct: 132 KAAGAFGAIRVWSRPRIPVPFSPPDGDFWLLAGDWYK 168
>HsM4503845 [G] KOG0563 Glucose-6-phosphate 1-dehydrogenase
Length = 515
Score = 29.6 bits (65), Expect = 8.9
Identities = 28/118 (23%), Positives = 51/118 (42%), Gaps = 8/118 (6%)
Query: 22 GFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTETLLDKSKSVKSVLTQLFPGNS 81
G + D + + + L + K + ++++V +V + + ++ VL Q + GN
Sbjct: 254 GIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQ-YVGNP 312
Query: 82 DTEG------IDTLNACYGGTNALFNSLN-WIESSAWDGRDAIVVCGDIAIYEKGAAR 132
D EG +D G T A F ++ ++E+ WDG I+ CG K R
Sbjct: 313 DGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVR 370
>Hs6005701 [IR] KOG0059 Lipid exporter ABCA1 and related proteins ABC
superfamily
Length = 1581
Score = 29.6 bits (65), Expect = 8.9
Identities = 20/56 (35%), Positives = 27/56 (47%), Gaps = 12/56 (21%)
Query: 229 HVPTCKLVTKSYGRLLY-------NDFRANPSLYPEIDA--SLASVEYETSLTDKN 275
H+P KL KS G+L+Y N F P LY ++D+ L Y S+T N
Sbjct: 692 HIPDAKLSAKSEGKLIYTLPLERTNKF---PELYKDLDSYPDLGIENYGVSMTTLN 744
>Hs21614520 [G] KOG0563 Glucose-6-phosphate 1-dehydrogenase
Length = 515
Score = 29.6 bits (65), Expect = 8.9
Identities = 28/118 (23%), Positives = 51/118 (42%), Gaps = 8/118 (6%)
Query: 22 GFVNDREDIYSMSLTVLSKLLKNYNIDTNNVGRIEVGTETLLDKSKSVKSVLTQLFPGNS 81
G + D + + + L + K + ++++V +V + + ++ VL Q + GN
Sbjct: 254 GIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQANNVVLGQ-YVGNP 312
Query: 82 DTEG------IDTLNACYGGTNALFNSLN-WIESSAWDGRDAIVVCGDIAIYEKGAAR 132
D EG +D G T A F ++ ++E+ WDG I+ CG K R
Sbjct: 313 DGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGKALNERKAEVR 370
>At2g33150 [I] KOG1389 3-oxoacyl CoA thiolase
Length = 462
Score = 29.6 bits (65), Expect = 8.9
Identities = 19/77 (24%), Positives = 37/77 (47%), Gaps = 1/77 (1%)
Query: 37 VLSKLLKNYNIDTNNVGRIEVGTETLLDKSKSVKSVLTQLFPGNSDTEGIDTLN-ACYGG 95
VL L++ N++ + VG I VGT ++ + + + G +T + T+N C G
Sbjct: 82 VLRALIEKTNLNPSEVGDIVVGTVLAPGSQRASECRMAAFYAGFPETVAVRTVNRQCSSG 141
Query: 96 TNALFNSLNWIESSAWD 112
A+ + I++ +D
Sbjct: 142 LQAVADVAAAIKAGFYD 158
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,111,869
Number of Sequences: 60738
Number of extensions: 1135685
Number of successful extensions: 2814
Number of sequences better than 10.0: 20
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2766
Number of HSP's gapped (non-prelim): 22
length of query: 424
length of database: 30,389,216
effective HSP length: 109
effective length of query: 315
effective length of database: 23,768,774
effective search space: 7487163810
effective search space used: 7487163810
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)