ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV2712 good R KOG2719 General function prediction only Metalloprotease
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV2712 926382 925015 -456
(456 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJR117w [R] KOG2719 Metalloprotease 628 e-180
SPAC3H1.05 [R] KOG2719 Metalloprotease 347 3e-95
At4g01320 [R] KOG2719 Metalloprotease 308 1e-83
Hs18379366 [R] KOG2719 Metalloprotease 268 2e-71
7302848 [R] KOG2719 Metalloprotease 254 2e-67
ECU02g1380 [R] KOG2719 Metalloprotease 220 4e-57
CE19683 [R] KOG2719 Metalloprotease 215 1e-55
7302849 [R] KOG2719 Metalloprotease 149 8e-36
7302850 [R] KOG2719 Metalloprotease 129 7e-30
7294736 [R] KOG2719 Metalloprotease 87 5e-17
>YJR117w [R] KOG2719 Metalloprotease
Length = 453
Score = 628 bits (1620), Expect = e-180
Identities = 305/448 (68%), Positives = 364/448 (81%), Gaps = 1/448 (0%)
Query: 8 LQDILDSSSIPWKTIITGFTVAQFGFETYLTYRQYLALSNKNLPPVLVGEIDDETFQKSE 67
L+ ILD +IPWK II+GF++AQF FE+YLTYRQY LS LPPVL EIDDETF KS
Sbjct: 4 LKTILDHPNIPWKLIISGFSIAQFSFESYLTYRQYQKLSETKLPPVLEDEIDDETFHKSR 63
Query: 68 AYSRAKSKFSIVSNVINLAQNLIFIKFDILPKLWHLGNSFAQ-YFPSRFFPTSTIAQSLY 126
YSRAK+KFSI +V NLAQ L+FIK+D+ PK+WH+ S P RF ST+AQSL
Sbjct: 64 NYSRAKAKFSIFGDVYNLAQKLVFIKYDLFPKIWHMAVSLLNAVLPVRFHMVSTVAQSLC 123
Query: 127 FLTVMSNLSALMGLPLSYYQHFVLEEKFGFNKLTIKLWISDMIKSSLLGAVIGTPVLYLF 186
FL ++S+LS L+ LPLSYY HFVLEEKFGFNKLT++LWI+DMIKS L IG P+LYLF
Sbjct: 124 FLGLLSSLSTLVDLPLSYYSHFVLEEKFGFNKLTVQLWITDMIKSLTLAYAIGGPILYLF 183
Query: 187 LKIFEKFPSNFLWYICLFILVVQILALTIIPVFIMPLFNKFTPLEDGELKTEIENLAKKV 246
LKIF+KFP++FLWYI +F+ VVQILA+TIIPVFIMP+FNKFTPLEDGELK IE+LA +V
Sbjct: 184 LKIFDKFPTDFLWYIMVFLFVVQILAMTIIPVFIMPMFNKFTPLEDGELKKSIESLADRV 243
Query: 247 GFPLDKIFIVDGSKRSSHSNAYFTGLPFTSKRIVLYDTLVNDSTTDEIVAVLAHEIGHWQ 306
GFPLDKIF++DGSKRSSHSNAYFTGLPFTSKRIVL+DTLVN ++TDEI AVLAHEIGHWQ
Sbjct: 244 GFPLDKIFVIDGSKRSSHSNAYFTGLPFTSKRIVLFDTLVNSNSTDEITAVLAHEIGHWQ 303
Query: 307 KSHLLRMLAFSETHIFLVFSLFTAAYQNKSLYNXXXXXXXXXXXXDISKVITPQYPIIIG 366
K+H++ M+ FS+ H FL+FSLFT+ Y+N S YN + VIT ++PIIIG
Sbjct: 304 KNHIVNMVIFSQLHTFLIFSLFTSIYRNTSFYNTFGFFLEKSTGSFVDPVITKEFPIIIG 363
Query: 367 FLLFNDLLQPLDCLSTFLTNLVSRAHEYQSDAYAKELGYAPHLARALINLQIKNLSTMNV 426
F+LFNDLL PL+C F+ +L+SR HEYQ+DAYAK+LGY +L RALI+LQIKNLSTMNV
Sbjct: 364 FMLFNDLLTPLECAMQFVMSLISRTHEYQADAYAKKLGYKQNLCRALIDLQIKNLSTMNV 423
Query: 427 DPLYSSYHYSHPTLAERLIAIEYKNEKK 454
DPLYSSYHYSHPTLAERL A++Y +EKK
Sbjct: 424 DPLYSSYHYSHPTLAERLTALDYVSEKK 451
>SPAC3H1.05 [R] KOG2719 Metalloprotease
Length = 474
Score = 347 bits (889), Expect = 3e-95
Identities = 191/464 (41%), Positives = 283/464 (60%), Gaps = 31/464 (6%)
Query: 2 MGIVDILQDILDSSSIPWKTIITGFTVAQFGFETYLTYRQYLALSNKNLPPVLVGEIDDE 61
MGI+ L ILD PWK +I GF++ ++ ++ YL RQ L + P +L +D++
Sbjct: 31 MGILQHLMHILDIPGFPWKIVIAGFSIGKYAWDLYLRRRQVPYLLREKPPAILAEHVDEK 90
Query: 62 TFQKSEAYSRAKSKFSIVSNVINLAQNLIFIKFDILPKLWHLGNSFAQYFP--------- 112
+QK+ +Y+R KS FS + + LA +L+ IK+D L LW++ FP
Sbjct: 91 KYQKALSYARDKSWFSTIVSTFTLAVDLLIIKYDGLSYLWNITK-----FPWMDKLAASS 145
Query: 113 SRFFPTSTIAQSLYFLTVMSNLSALMGLPLSYYQHFVLEEKFGFNKLTIKLWISDMIKSS 172
SRF +++I S F+ ++ S L+ +P + Y FV+EEK+GFNK T+K+++ D++K
Sbjct: 146 SRFSLSTSITHSCVFMFGLTLFSRLIQIPFNLYSTFVIEEKYGFNKSTLKIFVIDLLKEL 205
Query: 173 LLGAVIGTPVLYLFLKIFEKFPSNFLWYICLFILVVQILALTIIPVFIMPLFNKFTPLED 232
LG ++ + V+ +F+KI KF NF+ Y +V ++ TI P IMPLF KFTPLE+
Sbjct: 206 SLGGLLMSVVVGVFVKILTKFGDNFIMYAWGAYIVFGLILQTIAPSLIMPLFYKFTPLEN 265
Query: 233 GELKTEIENLAKKVGFPLDKIFIVDGSKRSSHSNAYFTGLPFTSKRIVLYDTLVNDSTTD 292
G L+T+IE LA + FPL K++++D S+RS+HSNA+F GLP+ +K IVL+DTLV + T
Sbjct: 266 GSLRTQIEELAASINFPLKKLYVIDASRRSTHSNAFFYGLPW-NKGIVLFDTLVKNHTEP 324
Query: 293 EIVAVLAHEIGHWQKSH-LLRMLAFSETHIFLVFSLFTAAYQNKSLYNXXXXXXXXXXXX 351
E++A+L HE+GHW SH L+ + +F +F LF A +N SLY
Sbjct: 325 ELIAILGHELGHWYMSHNLINTIIDYGMSLFHLF-LFAAFIRNNSLYT------------ 371
Query: 352 DISKVITPQYPIIIGFLLFNDLLQPLDCLSTFLTNLVSRAHEYQSDAYAKELGYAPHLAR 411
S + P+I+G LLF+D L PL + TF +N VSR EYQ+DA+AK+LGYA L
Sbjct: 372 --SFNFITEKPVIVGLLLFSDALGPLSSILTFASNKVSRLCEYQADAFAKQLGYAKDLGD 429
Query: 412 ALINLQIKNLSTMNVDPLYSSYHYSHPTLAERLIAIEYKNEKKD 455
LI + NLS + D LY+SY++SHP L +RL AI+Y KK+
Sbjct: 430 GLIRIHDDNLSPLEFDSLYTSYYHSHPILVDRLNAIDYTTLKKN 473
>At4g01320 [R] KOG2719 Metalloprotease
Length = 459
Score = 308 bits (788), Expect = 1e-83
Identities = 183/476 (38%), Positives = 251/476 (52%), Gaps = 54/476 (11%)
Query: 16 SIPWKTIITGFTVAQFGFETYLTYRQYLALSNKNLPPVLVGEIDDETFQKSEAYS----- 70
+IP+ + GF + + FETYL RQ AL LP LVG I E F+KS AY
Sbjct: 2 AIPFMETVVGFMIVMYIFETYLDLRQLTALKLPTLPKTLVGVISQEKFEKSRAYRDIITE 61
Query: 71 --RAKSKFSIVSNVINLAQNLIFIKFDILPKLWHLGNSFAQYFPSRFFPTSTIAQSLYFL 128
S F V + + + + F ILP W + + P + I +L FL
Sbjct: 62 NFNICSYFHFVHEFVTILMDSAILFFGILPWFWKMSGAVLPRLG--LDPENEILHTLSFL 119
Query: 129 TVMSNLSALMGLPLSYYQHFVLEEKFGFNKLTIKLWISDMIKSSLLGAVIGTPVLYLFLK 188
+ S + LP S Y FV+E + GFNK TI ++I DMIK + L ++G P++ +
Sbjct: 120 AGVMTWSQITDLPFSLYSTFVIESRHGFNKQTIWMFIRDMIKGTFLSVILGPPIVAAIIF 179
Query: 189 IFEKFPSNFLWYICLFILVVQILALTIIPVFIMPLFNKFTPLEDGELKTEIENLAKKVGF 248
I +K Y+ F+ ++ ++ +TI PV I PLFNKFTPL DG+L+ +IE LA + F
Sbjct: 180 IVQKGGPYLAIYLWAFMFILSLVMMTIYPVLIAPLFNKFTPLPDGDLREKIEKLASSLKF 239
Query: 249 PLDKIFIVDGSKRSSHSNAYFTGLPFTSKRIVLYDTLVND-STTDEIVAVLAHEIGHWQK 307
PL K+F+VDGS RSSHSNAY G F +KRIVLYDTL+ DEIVAV+AHE+GHW+
Sbjct: 240 PLKKLFVVDGSTRSSHSNAYMYGF-FKNKRIVLYDTLIQQCKNEDEIVAVIAHELGHWKL 298
Query: 308 SHLLRMLAFSETHIFLVFSLFTAAYQNKSLYNXXXXXXXXXXXXDISKVITPQYPIIIGF 367
+H + FL F +T + L+ P++IG
Sbjct: 299 NHTTYSFIAVQILAFLQFGGYTLVRNSTDLFRSFGFDT---------------QPVLIGL 343
Query: 368 LLFNDLLQPLDCLSTFLTNLVSRAHEYQSDAYAKELGYAPHLARALINLQIK-------- 419
++F + PL L +F NLVSRA E+Q+DA+A +LGYA L AL+ LQ++
Sbjct: 344 IIFQHTVIPLQHLVSFGLNLVSRAFEFQADAFAVKLGYAKDLRPALVKLQVREDNNRTQT 403
Query: 420 --------------------NLSTMNVDPLYSSYHYSHPTLAERLIAIEYKNEKKD 455
NLS MN DPLYS+YHYSHP L ERL AI+ +++K D
Sbjct: 404 VTSICVTHLNGFFVGILQEENLSAMNTDPLYSAYHYSHPPLVERLRAIDGEDKKTD 459
>Hs18379366 [R] KOG2719 Metalloprotease
Length = 475
Score = 268 bits (684), Expect = 2e-71
Identities = 176/487 (36%), Positives = 253/487 (51%), Gaps = 58/487 (11%)
Query: 1 MMGIVDILQDILDSSSIPWKTIITGFTVAQFGFETYLTYRQY-LALSNKNLPPVLVGEID 59
M +D L ++ I ++ +TV + +ET+L RQ + + ++PP L +D
Sbjct: 3 MWASLDALWEMPAEKRIFGAVLLFSWTV--YLWETFLAQRQRRIYKTTTHVPPELGQIMD 60
Query: 60 DETFQKSEAYSRAKSKFSIVSNVINLAQNLIFIKFDILPKLWHLGNSFAQYFPSRFFPTS 119
ETF+KS Y KS FS S + + + + + F +P LW L F Y + F P
Sbjct: 61 SETFEKSRLYQLDKSTFSFWSGLYSETEGTLILLFGGIPYLWRLSGRFCGY--AGFGPEY 118
Query: 120 TIAQSLYFLTVMSNLSALMGLPLSYYQHFVLEEKFGFNKLTIKLWISDMIKSSLLGAVIG 179
I QSL FL + + SAL GLP S Y FV+EEK GFN+ T+ ++ D IK ++ I
Sbjct: 119 EITQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIKKFVVTQCIL 178
Query: 180 TPVLYLFLKIFEKFPSNFLWYICLFILVVQILALTIIPVFIMPLFNKFTPLEDGELKTEI 239
PV L L I + F Y LF LVV ++ +TI +I PLF+KFTPL +G+LK EI
Sbjct: 179 LPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKEEI 238
Query: 240 ENLAKKVGFPLDKIFIVDGSKRSSHSNAYFTGLPFTSKRIVLYDTLVNDST--------- 290
E +AK + FPL K+++V+GSKRSSHSNAYF G F +KRIVL+DTL+ + +
Sbjct: 239 EVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGF-FKNKRIVLFDTLLEEYSVLNKDIQED 297
Query: 291 ----------------------------TDEIVAVLAHEIGHWQKSHLLRMLAFSETHIF 322
+E++AVL HE+GHW+ H ++ + S+ + F
Sbjct: 298 SGMEPRNEEEGNSEEIKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSF 357
Query: 323 LVFSLFTAAYQNKSLYNXXXXXXXXXXXXDISKVITPQYPIIIGFL-LFNDLLQPLDCLS 381
L F LF K L+ P +IG L +F + P + +
Sbjct: 358 LCFFLFAVLIGRKELFAAFG--------------FYDSQPTLIGLLIIFQFIFSPYNEVL 403
Query: 382 TFLTNLVSRAHEYQSDAYAKELGYAPHLARALINLQIKNLSTMNVDPLYSSYHYSHPTLA 441
+F ++SR E+Q+DA+AK+LG A L ALI L NL D L+S +HYSHP L
Sbjct: 404 SFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLL 463
Query: 442 ERLIAIE 448
ERL A++
Sbjct: 464 ERLQALK 470
>7302848 [R] KOG2719 Metalloprotease
Length = 451
Score = 254 bits (649), Expect = 2e-67
Identities = 158/449 (35%), Positives = 245/449 (54%), Gaps = 39/449 (8%)
Query: 28 VAQFGFETYLTYRQYLALSNK-NLPPVLVGEIDDETFQKSEAYSRAKSKFSIVSNVI-NL 85
V + E Y++ RQ +P L + ++TF K+ Y + KF I V+ ++
Sbjct: 18 VIENALEIYISLRQVKVYQTALKVPAELKSHMGEDTFHKARKYGLDQEKFGIFKAVVMDV 77
Query: 86 AQNLIFIKFDILPKLWHLGNSFAQYFPSRFFPTSTIAQSLYFLTVMSNLSALMGLPLSYY 145
A + + ++ LW L ++ + I S F+ + + LS GLP Y
Sbjct: 78 ALLCMELYIGLIAVLWQLSVQVVDKL--QWDSKNEIIVSCVFVLISNVLSTFKGLPFKIY 135
Query: 146 QHFVLEEKFGFNKLTIKLWISDMIKSSLLGAVIGTPVLYLFLKIFEKFPSNFLWYICLFI 205
+ FVLEE GFNK T + + D +K L+ V+ P+ + I ++ NF ++ +F
Sbjct: 136 KIFVLEETHGFNKQTARFFAWDQLKGFLVTQVLMIPITAAIIFIVQRGGDNFFIWLWIFT 195
Query: 206 LVVQILALTIIPVFIMPLFNKFTPLEDGELKTEIENLAKKVGFPLDKIFIVDGSKRSSHS 265
V+ ++ LT+ P+FI PLF+K+TPLE G L+ IE+LA + FPL K+F+V+GSKRSSHS
Sbjct: 196 GVISLVLLTLYPIFIAPLFDKYTPLEKGALRQSIEDLAASLKFPLTKLFVVEGSKRSSHS 255
Query: 266 NAYFTGLPFTSKRIVLYDTLV------NDS-----------TTDEIVAVLAHEIGHWQKS 308
NAYF GL + SKRIVL+DTL+ +DS T +E++AVL HE+GHW+
Sbjct: 256 NAYFYGL-WNSKRIVLFDTLLLNKGKPDDSELSEEEKGKGCTDEEVLAVLGHELGHWKLG 314
Query: 309 HLLRMLAFSETHIFLVFSLFTAAYQNKSLYNXXXXXXXXXXXXDISKVITP-QYPIIIGF 367
H+ + + + H+FL+F +F ++ Y ++ P PI++G
Sbjct: 315 HVTKNIIIMQVHLFLMFLVFGNVFKYPPFY--------------VAMGFQPGTRPILVGL 360
Query: 368 LL-FNDLLQPLDCLSTFLTNLVSRAHEYQSDAYAKELGYAPHLARALINLQIKNLSTMNV 426
L+ F +L P + L F ++SR EYQ+D +A +LG+A L +ALI L + NL
Sbjct: 361 LIVFTYVLAPYNALMNFAMTILSRRFEYQADEFAFKLGFAEQLGQALIKLNVDNLGFPVY 420
Query: 427 DPLYSSYHYSHPTLAERLIAI-EYKNEKK 454
D LYS++++SHPTL +RL + E K EKK
Sbjct: 421 DWLYSTWNHSHPTLLQRLNRLKELKEEKK 449
>ECU02g1380 [R] KOG2719 Metalloprotease
Length = 410
Score = 220 bits (560), Expect = 4e-57
Identities = 145/436 (33%), Positives = 226/436 (51%), Gaps = 34/436 (7%)
Query: 21 TIITGFTVAQFGFETYLTYRQYLALSNKNLPP--VLVGEIDDETFQKSEAYSRAKSKFSI 78
+ + G ++ + F YL R+ LS PP V + E +K++AY+R K SI
Sbjct: 4 SFLLGISIMSYLFVVYLKVRELRQLSK---PPSKVYLKLTTLEQVKKTKAYNRDKLIMSI 60
Query: 79 VSNVINLAQNLIFIKFDILPKLWHLGNSFAQYFPSRFFPTSTIAQSLYFLTVMSNLSALM 138
+ L ++L IK +L N + ++F ++ + FL ++L L
Sbjct: 61 FELTLLLMRDLYLIKRGVLE------NVYTKHFMGSWYGDAL------FLVGYAHLQRLF 108
Query: 139 GLPLSYYQHFVLEEKFGFNKLTIKLWISDMIKSSLLGAVIGTPVLYLFLKIFEKF-PSNF 197
LPL F +E K GFNK T+ ++ D +K SL+ V+ P Y+ I +K+ ++F
Sbjct: 109 DLPLGVISTFYIEAKHGFNKTTLSTFLMDFLKMSLIITVLFGPFSYVSTNIIKKYYKTSF 168
Query: 198 LWYICLFILVVQILALTIIPVFIMPLFNKFTPLEDGELKTEIENLAKKVGFPLDKIFIVD 257
Y+ +F+ V QI + + P+ I PLFNKF +E+ LKT+IE LA++VG KI ++D
Sbjct: 169 YIYLWVFMAVFQIGLVIVYPIAIQPLFNKFEEMEESNLKTKIEKLAERVGICAKKILVMD 228
Query: 258 GSKRSSHSNAYFTGLPFTSKRIVLYDTLVNDSTTDEIVAVLAHEIGHWQKSHLLRMLAFS 317
SKRS HSNAYF GL KRIV+YDTL+ +E +A+L HE+GHW+ +H+++M
Sbjct: 229 ASKRSGHSNAYFIGLT-KEKRIVIYDTLLKQVDEEETLAILCHELGHWKHNHVVKM---- 283
Query: 318 ETHIFLVFSLFTAAYQNKSLYNXXXXXXXXXXXXDISKVITPQYPIIIGFLLFNDLLQPL 377
T + L+ L N SL + V+ P++I + F ++
Sbjct: 284 -TSLVLLIQLLYLYVLNVSLNSKLFG----------DVVLGKDLPLLIRCIYFLMVIGAF 332
Query: 378 DCLSTFLTNLVSRAHEYQSDAYAKELGYAPHLARALINLQIKNLSTMNVDPLYSSYHYSH 437
L N +SR E Q+D ++ LGY L+ L+ L KN S M DPLY++ ++H
Sbjct: 333 SVPVDVLRNFISRYFEAQADRFSVSLGYGKELSSGLVKLFEKNSSNMEPDPLYAAIVHTH 392
Query: 438 PTLAERLIAIEYKNEK 453
PT+ ER+ IE + K
Sbjct: 393 PTVIERIKLIEDEMNK 408
>CE19683 [R] KOG2719 Metalloprotease
Length = 442
Score = 215 bits (548), Expect = 1e-55
Identities = 147/448 (32%), Positives = 225/448 (49%), Gaps = 58/448 (12%)
Query: 29 AQFGFETYLTYRQYLALSNKNLPPVLVGE-IDDETFQKSEAYSRAKSKFSIVSNVINLAQ 87
A F ++ Y+T+RQY A N P V E I +E ++K+ Y F + N
Sbjct: 16 ALFLWDQYITFRQYKAHKNAVKRPNEVKELIGEEDYKKARDYKIDNHLFGFFHSWFN--- 72
Query: 88 NLIFIKFDILPKLWHLGNSFAQYFPSRFFPTSTIAQSL-YFLTVMSNLSALMGLPLSYYQ 146
+L Y+P ++ T++ + FL++ S + ++ LP Y
Sbjct: 73 -----------QLLLTAQLIGGYYPFLWYATASYPLHVAVFLSINSIIETIIDLPWDLYS 121
Query: 147 HFVLEEKFGFNKLTIKLWISDMIKSSLLGAVIGTPVLYLFLKIFEKFPSNFLWYICLFIL 206
F++E+ GFNK TI + D IK L+G + P++Y I F YI LF+
Sbjct: 122 TFIIEDAHGFNKQTIGFYFVDKIKKMLVGFALTMPIVYGIEWIIVNGGPYFFVYIWLFVS 181
Query: 207 VVQILALTIIPVFIMPLFNKFTPLEDGELKTEIENLAKKVGFPLDKIFIVDGSKRSSHSN 266
VV +L +TI P FI PLF+K+ PL DG+LKT+IE LA + +PL ++++V+GSKRS+HSN
Sbjct: 182 VVVLLLMTIYPTFIAPLFDKYFPLPDGDLKTKIEQLAASLSYPLTELYVVNGSKRSAHSN 241
Query: 267 AYFTGLPFTSKRIVLYDTLVNDS---------------------------TTDEIVAVLA 299
AY G + +KRIVLYDTL++ + DE+VAVL
Sbjct: 242 AYMYGF-WKNKRIVLYDTLLSGAEKEKVHELYVAAGEKIEETENDKKRGMNNDEVVAVLG 300
Query: 300 HEIGHWQKSHLLRMLAFSETHIFLVFSLFTAAYQNKSLYNXXXXXXXXXXXXDISKVITP 359
HE+GHW H L L +E ++F F++F Y+ ++LY TP
Sbjct: 301 HELGHWALWHTLINLVITEVNLFFSFAVFGYFYKWEALYQGFGYHD------------TP 348
Query: 360 QYPIIIGFLLFNDLLQPLDCLSTFLTNLVSRAHEYQSDAYAKELGYAPHLARALINLQIK 419
P+I L+F +L + L++ + SR+ E+ +D +A LG+ +L AL L +
Sbjct: 349 --PVIGMMLIFQFVLALYNQLASIGMVIHSRSAEFGADEFAANLGHGENLIGALTKLGVD 406
Query: 420 NLSTMNVDPLYSSYHYSHPTLAERLIAI 447
NLS D LYS ++HP + ER+ A+
Sbjct: 407 NLSMPINDSLYSWCTHTHPPVVERVAAV 434
>7302849 [R] KOG2719 Metalloprotease
Length = 447
Score = 149 bits (376), Expect = 8e-36
Identities = 116/451 (25%), Positives = 213/451 (46%), Gaps = 46/451 (10%)
Query: 22 IITGFTVAQFGFETYLTYRQY-LALSNKNLPPVLVGEIDDETFQKSEAYSRAKSKFSIVS 80
II F V + YL R +A + +P V+ + E + K Y K F+IV+
Sbjct: 15 IIIAFLVLDNLWGVYLMLRDIQVAYKTQQVPNVISPYLPQELYDKMRVYKIHKGWFTIVN 74
Query: 81 NVIN-LAQNLIFIKFDILPKLWHLGNSFAQYFPSRFFPTSTIAQSLYFLTVMSNLSALMG 139
+++ + ++ + F L+ + A S++ S+ F+ ++S L
Sbjct: 75 TLLSAVILGIMELYFGFYAWLYGVAGKCAL---SKWMEHEACV-SVIFVLLLSVYFWLKS 130
Query: 140 LPLSYYQHFVLEEKFGFNK----LTIKLWISDMIKSSLLGAVIGTPVLYLFLKIFEKFPS 195
+P Y+ ++ K I ++ D++ +++ ++ ++Y+F+ + P
Sbjct: 131 VPAMIYESCCIKSLQPRPKPPWWSRICHFVVDLVVGAMITTLVVVALVYMFIGLGPYAPL 190
Query: 196 NFLWYICLFILVVQILALTIIPVFIMPLFNKFTPLEDGELKTEIENLAKKVGFPLDKIFI 255
+ L L++ ++ L +IP I P + PLE+ L+T++E L ++VGFP+ ++ I
Sbjct: 191 G----LYLQSLILTMIVLLLIPFMIHPFVGQSVPLENSNLRTQLEYLTRQVGFPMSQVRI 246
Query: 256 VDGSKRSSHSNAYFTGLPFTSKRIVLYDTLV-NDSTTD----------------EIVAVL 298
+ ++ SNA+F G KRIV++DTL+ N +D ++VAV+
Sbjct: 247 IRVHDPNTGSNAFFYGC-CCLKRIVIFDTLLLNRGKSDLSHLTAEELGRGLADPQVVAVV 305
Query: 299 AHEIGHWQKSHLLRMLAFSETHIFLVFSLFTAAYQNKSLYNXXXXXXXXXXXXDISKVIT 358
AHE+GHW+ H + + + H+ L LF + + +Y
Sbjct: 306 AHELGHWRNGHFYKAIMAFQVHLILTILLFAFLFSHGPIYQAVGFPPGLQ---------- 355
Query: 359 PQYPIIIGFLL-FNDLLQPLDCLSTFLTNLVSRAHEYQSDAYAKELGYAPHLARALINLQ 417
P +IG L+ F +L P L+ F ++R EYQ+D +A +LGY L +AL+ L
Sbjct: 356 ---PTVIGCLIIFGFVLTPYMTLANFSMLSMTRCFEYQADRFAYQLGYGGELRQALLKLY 412
Query: 418 IKNLSTMNVDPLYSSYHYSHPTLAERLIAIE 448
NL+ DP YSS++++HPT+ +RL +E
Sbjct: 413 ADNLAFPVSDPCYSSWNHTHPTMLDRLSRLE 443
>7302850 [R] KOG2719 Metalloprotease
Length = 426
Score = 129 bits (325), Expect = 7e-30
Identities = 109/428 (25%), Positives = 184/428 (42%), Gaps = 40/428 (9%)
Query: 37 LTYRQYLALSNKNL-PPVLVGEIDDETFQKSEAYSRAKSKFSIVSNVINLAQNLIFIKFD 95
LT RQ L N + P L G I E + ++ Y K++ I +I+L L +
Sbjct: 3 LTKRQQLVCLNAIMVPEELRGIIPPEIYHRARIYELHKTELQIWKYLIDLIITLCELILG 62
Query: 96 ILPKLWHLGNSFAQYFPSRFFPTSTIAQSLYFLTVMSNLSALMGLPLSYYQHFVLEEKFG 155
P LW L Q S+ I +L F+ ++ + LP+ Y +LE ++G
Sbjct: 63 FYPFLWSLSAKTLQKITSQ-----EIWITLIFVFYLTIYICIRFLPVLIYDKCLLELRYG 117
Query: 156 FN-KLTIKLWISDMIKSSLLGAVIGTPVLYLFLKIFEKFPSNFLWYICLFILVVQILALT 214
+ K L+ S LL ++ P+ + + F + LF +L +
Sbjct: 118 MSGKFPWYLYCCIGAMSILLSQLVLFPLAAAIVFSVKFIGYYFFLWFWLFWATFTLLLVF 177
Query: 215 IIPVFIMPLFNKFTPLEDGE-LKTEIENLAKKVGFPLDKIFIVDGSKRSSHSNAYFTGLP 273
+P +P + L +G L E++ + VGFP+ ++FI+ ++ +SNAYF G
Sbjct: 178 FLPYCCIPCIGRQVVLPEGTALYMEVKRVCDVVGFPMKRVFIIK-TRTMQYSNAYFYG-S 235
Query: 274 FTSKRIVLYDTLVNDS----------------TTDEIVAVLAHEIGHWQKSHLLRMLAFS 317
KRIV++DTL+ + T ++ V+ HE+GHW+ H +
Sbjct: 236 CCLKRIVIFDTLLLNKGKEPNEIHPYEVGRGLTNIQVAGVVCHELGHWKHGHFYKATIIM 295
Query: 318 ETHIFLVFSLFTAAYQNKSLYNXXXXXXXXXXXXDISKVITPQYPIIIGFLL-FNDLLQP 376
+ H F+ LF + + LY PII+GF++ L P
Sbjct: 296 KIHFFITMGLFGLFFHSPQLYMAVGFEPGVM-------------PIIVGFIIVLKFALTP 342
Query: 377 LDCLSTFLTNLVSRAHEYQSDAYAKELGYAPHLARALINLQIKNLSTMNVDPLYSSYHYS 436
L+ L R EY +D +A +GY+ L AL+ + ++S D Y+ +H++
Sbjct: 343 YLTLANVLMLWNLRRFEYAADKFAHRMGYSIQLRMALVKIYADHMSFPVYDQCYARWHHT 402
Query: 437 HPTLAERL 444
HPT+ +RL
Sbjct: 403 HPTILQRL 410
>7294736 [R] KOG2719 Metalloprotease
Length = 504
Score = 87.0 bits (214), Expect = 5e-17
Identities = 96/463 (20%), Positives = 181/463 (38%), Gaps = 58/463 (12%)
Query: 14 SSSIPWKTIITGFTVAQFGFETYLTYRQYLALSNKNLPPV-LVGEIDDETFQKSEAYSRA 72
S I + I+ V F L RQ ++PP + G + E FQ S+
Sbjct: 67 SDPILLRHILCLVIVVHNSFHLILCCRQLKLCKRTSVPPKQMEGILSQEAFQASKDKQLH 126
Query: 73 KSKFSIVSNVINLAQNLIFIKFDILPKLWHLGNSFAQYFPSRFFPTSTIAQSLYFLTVMS 132
S I + I+ + + + L LW L + Y S + ++ F+TV S
Sbjct: 127 ASSLEIFNIAIDTLYSCLDLYLCTLAFLWKLTVGWYHYADSTWL-------NVTFMTVFS 179
Query: 133 NLSALMGLPLSYYQHFVLEEKFGFNKLTIKLWISDMIKSSLLGAVIGTPVLYLFLKIFEK 192
+ LP +Y+ VL+ ++ + + + + AVI +++ + + +
Sbjct: 180 TYLVVRKLPSLFYEKLVLDPRYNVDPEKTPPLLGLICALVFVVAVIPLTAIFMAIHMLSE 239
Query: 193 FPSNFLWYICLFILV----VQILALTIIPVFIMPLFNKFTPLEDGELKTEIENLAKKVGF 248
WY LF+ + + +L L + +F +P K + ++ ++ + F
Sbjct: 240 ------WYFTLFVWLGLVGLSVLVLAFVGLFGVPCLGKSRKMNSTDMDNSLKAVLDDFNF 293
Query: 249 PLDKIFIVDGSKRSSHSNAYFTGLPFTSKRIVLYDTL-------------------VNDS 289
P ++++V + A+ G R+ ++D L +ND
Sbjct: 294 P-GRVYMVH-TFHVGRPTAWVMGC-CCCLRLDIHDNLKWNRGFSSDDFDWGQMGAGLND- 349
Query: 290 TTDEIVAVLAHEIGHWQKSHLLRMLAFSETHIFLVFSLFTAAYQNKSLYNXXXXXXXXXX 349
+++ A +AH++ HWQ H+ + LA ++ + LF + +LY
Sbjct: 350 --EQLAAFVAHQLAHWQLWHVAKGLALIYFYLLIYLLLFGICNRWITLYAAAG------- 400
Query: 350 XXDISKVITPQYPIIIGFLLFNDLLQPL-DCLSTFLTNLVSRAHEYQSDAYAKELGYAPH 408
T YP +GF L L P+ +ST++ R EY +DAY GY
Sbjct: 401 -------FTTFYPSSVGFWLVYKYLMPIYHDISTWIVFFCIRHFEYAADAYVNRRGYGLP 453
Query: 409 LARALINLQIKNLSTMNVDPLYSSYHYSHPTLAERLIAIEYKN 451
+ AL+ L + VD Y +H P++ +R+ ++ N
Sbjct: 454 MRAALLKLFSDDYEFPYVDQCYLMWHRLRPSVLQRIDNLQRLN 496
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.324 0.140 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,345,541
Number of Sequences: 60738
Number of extensions: 1034415
Number of successful extensions: 3431
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 3389
Number of HSP's gapped (non-prelim): 12
length of query: 456
length of database: 30,389,216
effective HSP length: 110
effective length of query: 346
effective length of database: 23,708,036
effective search space: 8202980456
effective search space used: 8202980456
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)