ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV2958 good U KOG2280 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein VPS16
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV2958 1000988 1003366 793
(793 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL045w [U] KOG2280 Vacuolar assembly/sorting protein VPS16 516 e-146
SPAC824.05 [U] KOG2280 Vacuolar assembly/sorting protein VPS16 196 2e-49
Hs17978479 [U] KOG2280 Vacuolar assembly/sorting protein VPS16 178 3e-44
7299155 [U] KOG2280 Vacuolar assembly/sorting protein VPS16 176 2e-43
Hs17978481 [U] KOG2280 Vacuolar assembly/sorting protein VPS16 104 5e-22
At2g38020 [U] KOG2280 Vacuolar assembly/sorting protein VPS16 93 1e-18
CE24785 [U] KOG2280 Vacuolar assembly/sorting protein VPS16 91 9e-18
Hs17978483 [U] KOG2280 Vacuolar assembly/sorting protein VPS16 89 3e-17
>YPL045w [U] KOG2280 Vacuolar assembly/sorting protein VPS16
Length = 798
Score = 516 bits (1329), Expect = e-146
Identities = 300/808 (37%), Positives = 475/808 (58%), Gaps = 36/808 (4%)
Query: 4 NPSLNWERLQSLFYRSQTLQSIGRKPS-------ATGLSVYLVAEPEKTFVYNYTDELQL 56
NPS +WERL+ +FYRS+ + + + P+ A L+V V + VYNY +L
Sbjct: 3 NPSFDWERLKDVFYRSRAIGEL-KWPTQYEEFKCALSLTVIAVEIQDFIQVYNYFGQLLG 61
Query: 57 TLNHEALPSAHLKSVIE-DDQLVVIMKDRVRVYLSLITEEFKEHNILDKERQPL------ 109
+N + + +K + D++L+++ K +++ K + L E PL
Sbjct: 62 KINLQRIHEDIIKFEFDKDEKLILVTKSSIKIV--------KGWSPLTIESVPLQDPTID 113
Query: 110 SIWDYKDGIVITTDFR-IYRIYHQEQ--LFPNL--AFSLLLKDHWFTNKSQIVLLDSSGT 164
+IWDY +GI++ R IY++ E L+ N ++LL K+HW N I+LLD
Sbjct: 114 TIWDYHNGIMLLAKSRDIYKLNGNEWELLYENKDKKYNLLTKNHWSCNDDSIILLDVDHV 173
Query: 165 VIIGNILSKELRQFEGWTGWYKGSISENGFVCLVNAKLNNLIVFDDDLNKPLIEVKLDEL 224
+ L+ + W+K +IS GF+CL N K N L +F D + L+E LD
Sbjct: 174 YQVSTSNGALLKLITD-SSWHKVTISSRGFICLYNMKDNKLQIFRDPA-RILMEHNLDST 231
Query: 225 PKNIAWCANDLICCNFGDDEVRLIGSEKDYVSFWLPSHIVGLQSVSDGLKVITEDHIEFV 284
P +I WC ND + C+F +DE++L G + YV+FW P + L++ DGLKVIT + I F+
Sbjct: 232 PDDICWCGNDTVACSF-EDEIKLYGPDGLYVTFWYPFTVTNLRAEVDGLKVITTEKIYFL 290
Query: 285 SKVATYTSDIFSIGSTAPGAILLDSLNLLQNDENSPKAIENLKIINLKKAVDECVSAAGD 344
S+V TS+IF IGST PGA+L+DS +LL+ +++PKAIE LK L+K V +C++AA D
Sbjct: 291 SRVQPQTSNIFRIGSTEPGAMLVDSFSLLE--DHAPKAIEILKNFVLEKGVLDCIAAAID 348
Query: 345 EINSIWQKRLLSAASFGKDSLSSTEFNASQFVITCNYLRVLNFLKTVGIFLTLRQFISIG 404
E QK LL+AAS+GK SL F+AS FV CN +++LN ++ GIFLT+ ++ I
Sbjct: 349 EFEPKLQKMLLNAASYGKASLQYKSFDASIFVNACNTIKLLNCFRSFGIFLTVEEYRCIS 408
Query: 405 VEAIVLKLVNIRKIYESYQIIDHLKCPELIPVVFNEWSKGKILTSPDSGNEALYQVVHDR 464
++ ++ +L+ + YE QI L+ VF EW+K KI SPD ++ L + R
Sbjct: 409 LKGVIDRLLKYHRYYECIQICKLANERFLLGYVFTEWAKDKIKGSPDMEDDELLDKIKSR 468
Query: 465 ALALNVQ--LQLSKVANIAFLDGRHSLARKLALDDQNLLPKVDILLKMDEVNIATDEANK 522
+++ LQ+ VA +A+L+GR L+R LAL ++N +++ L +D+ +IA E K
Sbjct: 469 LSVIDMTDTLQMVAVAKVAYLEGRFQLSRNLALLEKNEEARIEQLYNLDDDSIALKECIK 528
Query: 523 SMDIPVVLFLLLYSKRVMSTAQFTKNLIVTMKDNNVYQFFQRNDFPFLYDYFRQTDDYLS 582
+ + + LL+ + ++ +Q TK LI+ M +N +Y ++ R D +LYD++RQTD ++
Sbjct: 529 VQNYSLTISLLIALSKKLTNSQLTKLLIIDMFNNPLYLYYMRMDKAYLYDFYRQTDRFID 588
Query: 583 LARLIWKHGKEEGQESNSLLSQVSDLYGKFMTNADVKRDRTTIERAKKLFLYQTDLSNKY 642
LA ++ + GKE+ Q +S L Q+ DLY + + V ++R +KL++YQ L ++
Sbjct: 589 LAHVLLQQGKEQ-QSLHSFLPQIKDLYSQVQNSEVVNNTIEQLQRQEKLWIYQESLGKRF 647
Query: 643 GINFHNQTCDETLSTLIKVGQRNEVKRMINEFKISERKFYFLKCSCLAKEHKLKELYSFS 702
I+F N T D+TLS LI+ GQ +VK ++ +FKISE+K Y LKC L + K EL F+
Sbjct: 648 AISFTNMTLDQTLSKLIETGQDKQVKEIVKKFKISEKKLYHLKCKTLVEAKKFDELLQFA 707
Query: 703 QEKKSPIGYLPFFKAVSKYANKKDAAIYVNMLSSLTYAEKLDMYLDCKAYHEAISLASHE 762
Q +KSPIGY+PF+ + + A+ YVNM+ L+Y EK +Y++C+ + +AI LA E
Sbjct: 708 QSRKSPIGYMPFYTYLKSRGHMDKASPYVNMIPGLSYQEKKKLYVECRGFRDAIQLAGKE 767
Query: 763 RDAIGLKQVLNRIPQNETQLRSLAMQQL 790
+D GLK++ N IP NE +L++LA + +
Sbjct: 768 KDIPGLKEIYNIIPPNEPELKALANETM 795
>SPAC824.05 [U] KOG2280 Vacuolar assembly/sorting protein VPS16
Length = 835
Score = 196 bits (497), Expect = 2e-49
Identities = 168/619 (27%), Positives = 309/619 (49%), Gaps = 31/619 (5%)
Query: 188 SISENGFVCLVNAKLNNLIVFDDDLNKPLIEVKLDELP-----KNIAWCANDLICCNFGD 242
SIS N + + + V D +K L++++L E K +AWC ND + +
Sbjct: 230 SISPNARYLALYESVGKVRVISSDFSKELLDLRLPETVAEASLKQMAWCGNDAVVL-VHE 288
Query: 243 DEVRLIGSEKDYVSFWLPSHIVGLQSVSDGLKVITEDHIEFVSKVATYTSDIFSIGSTAP 302
+ + L+G V + L +H + + DG++++T+D EF+ KV +IF IGS P
Sbjct: 289 NLLTLVGPFGGSVPY-LYNHTPIVSTEVDGVRILTKDSSEFLRKVPAPLENIFHIGSKTP 347
Query: 303 GAILLDSLNLLQ-NDENSPKAIENLKIINLKKAVDECVSAAGDEINSIWQKRLLSAASFG 361
GA L+++ ++ + K + LK L AVD CV A+ +E + WQK LL AAS G
Sbjct: 348 GAKLVEAFQKMKLKSVFAEKMLLELKD-ELHDAVDTCVQASLNEFSIEWQKVLLEAASLG 406
Query: 362 KDSLSSTEFNASQFVITCNYLRVLNFLK--TVGIFLTLRQFISIGVEAIVLKLVNIRKIY 419
K+SL +N ++V C LRVLN + VGI++T +++ +G+E ++ + + R++Y
Sbjct: 407 KNSLRM--YNHQEYVDVCRELRVLNAARDPNVGIYITHEEYLHLGLERLIQRF-SCRQLY 463
Query: 420 E-SYQIIDHLKCPELIPVVFNEWSKGKILTSPDSGNEALYQVVHDRALALNVQLQLSKVA 478
+ Q ++ P V+ +W++ I S + L +V + L+ + K+A
Sbjct: 464 GLAVQASMWMQIP--CDWVYIQWAQTYIKQSSEPEEVVLDNIV--KRLSSRKYISYEKIA 519
Query: 479 NIAFLDGRHSLARKLALDDQNLLPKVDILLKMDEVNIATDEANKSMDIPVVLFLLLYSKR 538
A+ +GR L+ KL + +V +LL M+ A + ++MD ++++++L K+
Sbjct: 520 RTAYQEGRLILSTKLLDFEPLAKHQVMLLLNMEAYEQALKKVIETMDNNLIIYVVLQIKQ 579
Query: 539 VMSTAQFTKNLIVTMKDNNVY-QFFQRNDFPFLYDYFRQTDDYLSLARLIWKHGKEEGQE 597
M+ A F + L VY +F ++ND L+D+F Q D+ +A L E+ +
Sbjct: 580 QMAIASFFQILNEYPDAVKVYVEFAKKNDRKTLHDFFYQDDNKQGIAVL----AVEDTLK 635
Query: 598 SNSLLSQVSDLYGKFMTNADVKR----DRTTIERAKKLFLYQTDLSNKYGINFHNQTCDE 653
+ ++ +++ L ++ K ++ + K L L QT +++ NF T +E
Sbjct: 636 TATVNQRITSLKSAAKVCSESKELSLEEKCLGDEIKLLQLQQT-YEDQFTGNFVGLTVNE 694
Query: 654 TLSTLIKVGQRNEVKRMINEFKISERKFYFLKCSCLAKEHKLKELYSFSQE-KKSPIGYL 712
+ LI++ Q ++ ++F+I E++F +LK L ++ ++ ++SPIG+
Sbjct: 695 VVVKLIQINQTQRANKLRSDFQIPEKRFAWLKLRALVAIRDWVQIEQWAGSMRRSPIGFE 754
Query: 713 PFFKAVSKYANKKDAAIYVNMLSSLTYAEKLDMYLDCKAYHEAISLASHERDAIGLKQVL 772
PF + NKK+AA Y+ + LT EK+DM++ A A+ + L +L
Sbjct: 755 PFVTEILSAGNKKEAAKYIPRCTQLTTQEKVDMWVQVGDVKSASEEAAKSKSGSVLGDLL 814
Query: 773 NRI-PQNETQLRSLAMQQL 790
R+ E++ A+ QL
Sbjct: 815 ERVQTMPESRFVQNALDQL 833
>Hs17978479 [U] KOG2280 Vacuolar assembly/sorting protein VPS16
Length = 839
Score = 178 bits (451), Expect = 3e-44
Identities = 168/621 (27%), Positives = 293/621 (47%), Gaps = 42/621 (6%)
Query: 171 LSKELRQFEGWTGWYKGSISENGFVCLVNAKLNN-LIVFDDDLNKPLIEVKLDELPKNIA 229
+S L+ +T + ++ G++ + A L L F+ ++ P PK +
Sbjct: 219 VSSFLQMAVSFTYRHLALFTDTGYIWMGTASLKEKLCEFNCNIRAP---------PKQMV 269
Query: 230 WCAN----DLICCNFGDDEVRLIGSEKDYVSFWLPSHIVGLQSVSDGLKVITEDHIEFVS 285
WC+ + + + ++G + + F L + + DG+++ + EF+
Sbjct: 270 WCSRPRSKERAVVVAWERRLMVVGDAPESIQFVLDEDSYLVPEL-DGVRIFSRSTHEFLH 328
Query: 286 KVATYTSDIFSIGSTAPGAILLDSLNLLQNDENSPKAIENLKIIN----LKKAVDECVSA 341
+V + +IF I S APGA+LL++ + ++ S KA E L+ I L +AV +C+ A
Sbjct: 329 EVPAASEEIFKIASMAPGALLLEAQK--EYEKESQKADEYLREIQELGQLTQAVQQCIEA 386
Query: 342 AGDEINSIWQKRLLSAASFGKDSLSSTEFNASQFVITCNYLRVLNFLKT--VGIFLTLRQ 399
AG E QK LL AASFGK L F FV C LRVLN ++ +GI LT Q
Sbjct: 387 AGHEHQPDMQKSLLRAASFGKCFLD--RFPPDSFVHMCQDLRVLNAVRDYHIGIPLTYSQ 444
Query: 400 FISIGVEAIVLKLVNIRKIYE-SYQIIDHLKCPELIPV--VFNEWSKGKILTSPDSGNEA 456
+ + ++ ++ +LV +R++Y + QI ++L+ PE+ V + W+ K+ D +E
Sbjct: 445 YKQLTIQVLLDRLV-LRRLYPLAIQICEYLRLPEVQGVSRILAHWACYKV-QQKDVSDED 502
Query: 457 LYQVVHDRALALNVQLQLSKVANIAFLDGRHSLARKLALDDQNLLPKVDILLKMDEVNIA 516
+ + ++ + L + S +A A+ GR LA KL + +V +LLKM +A
Sbjct: 503 VARAINQK-LGDTPGVSYSDIAARAYGCGRTELAIKLLEYEPRSGEQVPLLLKMKRSKLA 561
Query: 517 TDEANKSMDIPVVLFLLLYSKRVMSTAQFTKNLIVTMKDNNVY-QFFQRNDFPFLYDYFR 575
+A +S D +V +LL+ K ++ F L ++Y QF + + L D +
Sbjct: 562 LSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQFCKHQELETLKDLYN 621
Query: 576 QTDDYLSLA--RLIWKHGKEEGQESN-SLLSQVSDLYGKFMTNADVKRDRTTIERAKKLF 632
Q D++ L + + EE E + L +D + K K E +L
Sbjct: 622 QDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAAK----ATEDQMRLL 677
Query: 633 LYQTDLSNKYGINFHNQTCDETLSTLIKVGQRNEVKRMINEFKISERKFYFLKCSCLAKE 692
Q L ++ G F + + +T++TLI G +++ +F+I +++ ++LK + LA
Sbjct: 678 RLQRRLEDELGGQFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPDKRLWWLKLTALADL 737
Query: 693 HKLKELYSFSQEKKSPIGYLPFFKAVSKYANKKDAAIYVNMLSSLTYAEKLDMYLDCKAY 752
+EL FS+ KKSPIGYLPF + K NK +A Y + + +K+ L
Sbjct: 738 EDWEELEKFSKSKKSPIGYLPFVEICMKQHNKYEAKKYASRVGP---EQKVKALLLVGDV 794
Query: 753 HEAISLASHERDAIGLKQVLN 773
+A +A R+ L VL+
Sbjct: 795 AQAADVAIEHRNEAELSLVLS 815
>7299155 [U] KOG2280 Vacuolar assembly/sorting protein VPS16
Length = 833
Score = 176 bits (445), Expect = 2e-43
Identities = 145/519 (27%), Positives = 256/519 (48%), Gaps = 36/519 (6%)
Query: 263 IVGLQSVSDGLKVITEDHIEFVSKVATYTSDIFSIGSTAPGAILLDSLNLLQNDENSPKA 322
++ L + DG+++IT+ E + ++ +IF++ S P + L ++ + E S K+
Sbjct: 309 VMFLVAEMDGVRIITQSSHEIIQRLPKCVENIFAVNSQEPASYLFEAQKKFE--EKSYKS 366
Query: 323 IENLKIINLK--KAVDECVSAAGDEINSIWQKRLLSAASFGKDSLSSTEFNASQFVITCN 380
E L + K AV EC+ AA E QK LL A FGK + + N +++
Sbjct: 367 DEYLSMCREKIDLAVSECIEAASYEFCPETQKSLLRTAYFGKGFIRN--HNPDEYMRIMR 424
Query: 381 YLRVLNFLK--TVGIFLTLRQFISIGVEAIVLKLVNIRKIYESYQIIDHLKCPELIPVVF 438
LRVLN L+ + + +T +QF + E I+ +LV + + Q+ HL PE +
Sbjct: 425 ILRVLNTLRHERIAMPITFKQFSHLNTEVILSRLVFRKHYAIAIQVAKHLNLPE--SWIL 482
Query: 439 NEWSKGKILTSPDSGNEALYQVVHDRALALNVQ-LQLSKVANIAFLDGRHSLARKLALDD 497
W+ K++ P+ A + + ++ +V+ + +A+ A GR LA KL +
Sbjct: 483 EHWAYHKVMNDPNDTEVA--RKITEKFKNPSVEGISFCNIASKAHQAGRDDLAIKLLELE 540
Query: 498 QNLLPKVDILLKMDEVNIATDEANKSMDIPVVLFLLLYSKRVMSTAQFTKNLIVTMKDN- 556
V +LLKM + + A A +S D ++ +LL K M + NL +T++D+
Sbjct: 541 SRASLHVPLLLKMRKFDRAVGSATQSGDTELITQVLLEMKMHMMLS----NLHMTIRDHP 596
Query: 557 ---NVYQFFQR-NDFPFLYDYFRQTDDYLSLARLIWKHGKE-EGQESNSLLSQVSDLY-- 609
N+Y+ R ++ LY + DD ++A +++ E EG ESN LS + + Y
Sbjct: 597 LALNIYKKIMRESNRAGLYGIYNTEDDQKAIAEYHFQNAIETEGLESN--LSMIGNAYAQ 654
Query: 610 GKFMTNADVKRDRTTIERAKKLFLYQTDLSNKYGINFHNQTCDETLSTLIKVGQRNEVKR 669
G+ A++ D + +L Q LS KY ++ + + ET+ L+ +G+ E +R
Sbjct: 655 GRCTLEAELCADTS------RLIKLQKTLSTKYNVSLNGLSIHETIQELLLIGELKEAER 708
Query: 670 MINEFKISERKFYFLKCSCLAKEHKLKELYSFSQEKKSPIGYLPFFKAVSKYANKKDAAI 729
+ +EFK+ +R+F++L+ L+ +HK +EL ++ KKSPIGY PF + K N +A
Sbjct: 709 IRSEFKVPDRRFWWLRILTLSSQHKWEELEKLAKSKKSPIGYDPFVEVCLKQDNVMEARK 768
Query: 730 YVNMLSSLTYAEKLDMYLDCKAYHEAISLASHERDAIGL 768
Y+ ++ Y+ ++EAI A +RD L
Sbjct: 769 YIPRCRD---NRRVVWYMRANLFNEAIDSAFEQRDVHSL 804
>Hs17978481 [U] KOG2280 Vacuolar assembly/sorting protein VPS16
Length = 695
Score = 104 bits (260), Expect = 5e-22
Identities = 99/382 (25%), Positives = 180/382 (46%), Gaps = 17/382 (4%)
Query: 399 QFISIGVEAIVLKLVNIRKIYE-SYQIIDHLKCPELIPV--VFNEWSKGKILTSPDSGNE 455
Q+ + ++ ++ +LV +R++Y + QI ++L+ PE+ V + W+ K+ D +E
Sbjct: 300 QYKQLTIQVLLDRLV-LRRLYPLAIQICEYLRLPEVQGVSRILAHWACYKV-QQKDVSDE 357
Query: 456 ALYQVVHDRALALNVQLQLSKVANIAFLDGRHSLARKLALDDQNLLPKVDILLKMDEVNI 515
+ + ++ + L + S +A A+ GR LA KL + +V +LLKM +
Sbjct: 358 DVARAINQK-LGDTPGVSYSDIAARAYGCGRTELAIKLLEYEPRSGEQVPLLLKMKRSKL 416
Query: 516 ATDEANKSMDIPVVLFLLLYSKRVMSTAQFTKNLIVTMKDNNVY-QFFQRNDFPFLYDYF 574
A +A +S D +V +LL+ K ++ F L ++Y QF + + L D +
Sbjct: 417 ALSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQFCKHQELETLKDLY 476
Query: 575 RQTDDYLSLA--RLIWKHGKEEGQESN-SLLSQVSDLYGKFMTNADVKRDRTTIERAKKL 631
Q D++ L + + EE E + L +D + K K E +L
Sbjct: 477 NQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAAK----ATEDQMRL 532
Query: 632 FLYQTDLSNKYGINFHNQTCDETLSTLIKVGQRNEVKRMINEFKISERKFYFLKCSCLAK 691
Q L ++ G F + + +T++TLI G +++ +F+I +++ ++LK + LA
Sbjct: 533 LRLQRRLEDELGGQFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPDKRLWWLKLTALAD 592
Query: 692 EHKLKELYSFSQEKKSPIGYLPFFKAVSKYANKKDAAIYVNMLSSLTYAEKLDMYLDCKA 751
+EL FS+ KKSPIGYLPF + K NK +A Y + + +K+ L
Sbjct: 593 LEDWEELEKFSKSKKSPIGYLPFVEICMKQHNKYEAKKYASRVGP---EQKVKALLLVGD 649
Query: 752 YHEAISLASHERDAIGLKQVLN 773
+A +A R+ L VL+
Sbjct: 650 VAQAADVAIEHRNEAELSLVLS 671
>At2g38020 [U] KOG2280 Vacuolar assembly/sorting protein VPS16
Length = 746
Score = 93.2 bits (230), Expect = 1e-18
Identities = 57/178 (32%), Positives = 100/178 (56%), Gaps = 8/178 (4%)
Query: 189 ISENGFVCLVNAKLNNLIVFDDDLNKPLIEVKLDEL--PKNIAWCANDLICCNFGDDEVR 246
+S NG + ++V D + + I+ + P+ +AWC D + + D+++
Sbjct: 248 VSPNGKFLTLFTHDGRIVVVDMETKQIAIDYSCESALPPQQMAWCGMDSVLL-YWDEDLM 306
Query: 247 LIGSEKDYVSFWLPSHIVGLQSVSDGLKVITEDHIEFVSKVATYTSDIFSIGSTAPGAIL 306
++G D V ++ I+ L DG+++++ ++EF+ +V T IF IGST+P A+L
Sbjct: 307 MVGPVGDPVHYFYDEPII-LIPECDGVRILSNTNLEFLQRVPDSTESIFKIGSTSPAALL 365
Query: 307 LDSLNLLQNDENSPKAIENLKII--NLKKAVDECVSAAGDEINSIWQKRLLSAASFGK 362
D+L+ D S KA ENL++I +L +AV+ C+ AAG E + Q+ LL AAS+G+
Sbjct: 366 YDALD--HFDRRSAKADENLRLIRSSLSEAVESCIDAAGHEFDVTRQRALLRAASYGQ 421
Score = 67.8 bits (164), Expect = 6e-11
Identities = 77/316 (24%), Positives = 130/316 (40%), Gaps = 66/316 (20%)
Query: 468 LNVQLQLSK------VANIAFLDGRHSLARKLALDDQNLLPKVDILLKMDEVNIATDEAN 521
+ QLQL K VA A GR LA L + +V +LL + E + A +A
Sbjct: 449 IEFQLQLCKGISYAAVATHADNCGRRKLAAMLVEHEPRSTKQVPLLLSIGEEDTALVKAT 508
Query: 522 KSMDIPVVLFLLLYSKRVMSTAQFTKNLIVTMKDNNVYQFFQRNDFPFLYDYFRQTDDYL 581
+S D +V + ++ +Q+
Sbjct: 509 ESGDTDLVYLV-------------------------IFHIWQKE---------------- 527
Query: 582 SLARLIWKHGKEEGQESNSLLSQVSDLYGKFMTNADVKRD------------RTTIERAK 629
+A L+WK + G+ N + S+ S L+G + + R+ + E AK
Sbjct: 528 -VAFLLWKESWDMGK--NPMASKGSPLHGPRIKLIEKARNLFSQTKEHTFESKAAEEHAK 584
Query: 630 KLFL-YQTDLSNKYGINFHNQTCDETLSTLIKVGQRNEVKRMINEFKISERKFYFLKCSC 688
L + ++ + S K I F + + ++T+ T I +G ++ EFK+S++++Y+LK
Sbjct: 585 LLKIQHELEASTKQAI-FVDSSINDTIRTCIVLGNNRAAIKVKTEFKVSDKRWYWLKAFA 643
Query: 689 LAKEHKLKELYSFSQEKKSPIGYLPFFKAVSKYANKKDAAIYVNMLSSLTYAEKLDMYLD 748
LA L FS+EK+ P+G+ PF +A K +A Y+ LS L E+ + Y
Sbjct: 644 LATIKDWAALEKFSKEKRPPMGFRPFVEACIDADEKAEALKYIPKLSDL--VERGEAYAR 701
Query: 749 CKAYHEAISLASHERD 764
EA A+ D
Sbjct: 702 IGMAKEAADCAAQAND 717
>CE24785 [U] KOG2280 Vacuolar assembly/sorting protein VPS16
Length = 852
Score = 90.5 bits (223), Expect = 9e-18
Identities = 124/547 (22%), Positives = 234/547 (42%), Gaps = 69/547 (12%)
Query: 271 DGLKVITEDHIEFVSKVATYTSDIFSIGSTAPGAILLDSLNLLQNDENSPKAIENLKIIN 330
DG+++ +EFV + + + GA L + + + I +
Sbjct: 325 DGIRLFESTQVEFVEAASREKIAVLNRNPNEDGAHLYKAAQEMSQGTGHNSFAASTVIQD 384
Query: 331 LKKAVDECVSAAGDEINSIWQKRLLSAASFGKDSLSSTEFNASQFVITCNYLRVLNFLKT 390
L KA+D+C+S A D QK LL AA FG + ++T + ++ + +RVLN L+
Sbjct: 385 LYKAIDDCISTACDTWQPEEQKLLLKAARFGM-AYTNTTPDTTKLMRAIKEIRVLNELRM 443
Query: 391 V--GIFLTLRQFISIGVEAIVLKLVNIRKIYESYQIIDHL--KCPELIPVVFNEWSKGKI 446
V GI LT RQF +IG ++ +L+++ + ++ L + E + V EW + +
Sbjct: 444 VRTGIPLTHRQFRAIGETCVINRLIDMGSYSVAIKVAQWLGGETSENVDRVLLEWVR-RS 502
Query: 447 LTSPDSGNEALYQVVHDRALALNVQLQLSKVANIAFLD-GRHSLARKL----------AL 495
++ N + Q + AL + +L + +++ D R ++ KL
Sbjct: 503 ISKVSKSNMKMDQPALE-ALDEKISAKLLQFPHVSIADAARRAIEAKLPELARLFIRRET 561
Query: 496 DDQNLLPKVDILLKMDEVNIATDEANKSMDIPVVLFLLLYSKRVMSTAQFTKNLIVTMKD 555
DD N V +LL++++V+ A +A+ S+R Q ++L+ +
Sbjct: 562 DDAN---HVAVLLQLNDVSAALQKASA-------------SQRPQLIHQVVRHLMNSESR 605
Query: 556 NNVYQFFQRNDFPFLYDYFRQTDDYLSLARLIWKHGKEEGQESN---SLLSQVSDLYGKF 612
++ R P ++ L+ + G+ G S +LL Q SD +
Sbjct: 606 SSYELAISR--IPLAQCLYQD---------LVRQEGETRGASSRQMLALLEQASDFERQT 654
Query: 613 MTNADV-KRDRTTIERA---------------KKLFLYQTDLSNKYGINFHNQTCDETL- 655
+ + DV + +R ER K + D+S + D ++
Sbjct: 655 LFHFDVAETERNPDERLNALRRAKDAAKSMGDKAIEEILNDVSAFAPLQIQRGQADMSVR 714
Query: 656 STLIKVGQRN-EVKRMINEFKISERKFYFLKCSCLAKEHKLKELYSFSQEKKSPIGYLPF 714
T+I++ +V ++ + ++++++ LAK+ K+++L+ +Q K+SPIGY PF
Sbjct: 715 DTVIEMAHDTAKVAQLKQQARLTDKQVLLWTIEGLAKKGKMEQLFDLAQ-KRSPIGYAPF 773
Query: 715 FKAVSKYANKKDAAIYVNMLSSLTYAEKLDMYLDCKAYHEAISLASHERDAIGLKQVLNR 774
KA +Y + Y ++ Y + + +L K Y EA LA RD L V +
Sbjct: 774 VKACVRYKRLDEIKKYFAKVNG--YPDLVAAHLAMKNYVEAAKLAYDRRDRDVLHAVHMK 831
Query: 775 IPQNETQ 781
++ TQ
Sbjct: 832 SHEDPTQ 838
>Hs17978483 [U] KOG2280 Vacuolar assembly/sorting protein VPS16
Length = 323
Score = 88.6 bits (218), Expect = 3e-17
Identities = 74/275 (26%), Positives = 127/275 (45%), Gaps = 11/275 (4%)
Query: 503 KVDILLKMDEVNIATDEANKSMDIPVVLFLLLYSKRVMSTAQFTKNLIVTMKDNNVY-QF 561
+V +LLKM +A +A +S D +V +LL+ K ++ F L ++Y QF
Sbjct: 32 QVPLLLKMKRSKLALSKAIESGDTDLVFTVLLHLKNELNRGDFFMTLRNQPMALSLYRQF 91
Query: 562 FQRNDFPFLYDYFRQTDDYLSLA--RLIWKHGKEEGQESN-SLLSQVSDLYGKFMTNADV 618
+ + L D + Q D++ L + + EE E + L +D + K
Sbjct: 92 CKHQELETLKDLYNQDDNHQELGSFHIRASYAAEERIEGRVAALQTAADAFYKAKNEFAA 151
Query: 619 KRDRTTIERAKKLFLYQTDLSNKYGINFHNQTCDETLSTLIKVGQRNEVKRMINEFKISE 678
K E +L Q L ++ G F + + +T++TLI G +++ +F+I +
Sbjct: 152 K----ATEDQMRLLRLQRRLEDELGGQFLDLSLHDTVTTLILGGHNKRAEQLARDFRIPD 207
Query: 679 RKFYFLKCSCLAKEHKLKELYSFSQEKKSPIGYLPFFKAVSKYANKKDAAIYVNMLSSLT 738
++ ++LK + LA +EL FS+ KKSPIGYLPF + K NK +A Y + +
Sbjct: 208 KRLWWLKLTALADLEDWEELEKFSKSKKSPIGYLPFVEICMKQHNKYEAKKYASRVGP-- 265
Query: 739 YAEKLDMYLDCKAYHEAISLASHERDAIGLKQVLN 773
+K+ L +A +A R+ L VL+
Sbjct: 266 -EQKVKALLLVGDVAQAADVAIEHRNEAELSLVLS 299
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.136 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,812,085
Number of Sequences: 60738
Number of extensions: 1972591
Number of successful extensions: 5336
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 5303
Number of HSP's gapped (non-prelim): 10
length of query: 793
length of database: 30,389,216
effective HSP length: 114
effective length of query: 679
effective length of database: 23,465,084
effective search space: 15932792036
effective search space used: 15932792036
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)