ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV3165 check: MH R KOG1102 General function prediction only Rab6 GTPase activator GAPCenA and related TBC domain proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV3165 1068155 1066035 -707
(707 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL249c [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 498 e-140
YMR192w [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 301 2e-81
Hs19923325_1 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (c... 197 6e-50
Hs12232373 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 194 3e-49
Hs18590199 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (con... 190 7e-48
SPAC26F1.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and relate... 184 4e-46
CE27153 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 180 8e-45
CE27154 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 177 5e-44
7292646 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contai... 175 2e-43
CE07531 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contai... 165 3e-40
7295111 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 157 7e-38
Hs7662198 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (cont... 148 3e-35
Hs20532509 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (con... 147 7e-35
7296688 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contai... 144 5e-34
At5g15930 [R] KOG1102 Rab6 GTPase activator GAPCenA and related ... 133 1e-30
At3g02460 [R] KOG1102 Rab6 GTPase activator GAPCenA and related ... 131 4e-30
7303241 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 108 4e-23
Hs7661864 [R] KOG1102 Rab6 GTPase activator GAPCenA and related ... 107 8e-23
Hs13994322 [U] KOG2221 PDZ-domain interacting protein EPI64 cont... 102 2e-21
CE28983 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 99 2e-20
YGR100w [R] KOG4347 GTPase-activating protein VRP 99 3e-20
7299471 [U] KOG2221 PDZ-domain interacting protein EPI64 contain... 98 5e-20
SPBC215.01 [R] KOG4347 GTPase-activating protein VRP 94 5e-19
Hs21361485 [U] KOG2221 PDZ-domain interacting protein EPI64 cont... 90 1e-17
At3g07890 [U] KOG2058 Ypt/Rab GTPase activating protein 87 7e-17
CE28759 [TR] KOG2223 Uncharacterized conserved protein contains ... 87 1e-16
Hs17485595 [R] KOG4347 GTPase-activating protein VRP 86 1e-16
SPBC1778.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and relate... 84 1e-15
SPCC1259.11c [R] KOG4347 GTPase-activating protein VRP 83 2e-15
7300111 [U] KOG2058 Ypt/Rab GTPase activating protein 83 2e-15
Hs22043863 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 82 2e-15
Hs14733591 [TR] KOG2223 Uncharacterized conserved protein contai... 82 2e-15
Hs22042713 [R] KOG4347 GTPase-activating protein VRP 82 4e-15
SPCC1620.12c [R] KOG1102 Rab6 GTPase activator GAPCenA and relat... 81 5e-15
ECU11g1700 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 81 6e-15
CE17203 [U] KOG2221 PDZ-domain interacting protein EPI64 contain... 79 2e-14
CE08508 [U] KOG2058 Ypt/Rab GTPase activating protein 79 3e-14
Hs14745035 [TR] KOG2223 Uncharacterized conserved protein contai... 78 4e-14
Hs13376023 [U] KOG2058 Ypt/Rab GTPase activating protein 78 5e-14
7296423 [R] KOG4347 GTPase-activating protein VRP 78 5e-14
CE19171 [R] KOG4347 GTPase-activating protein VRP 76 2e-13
CE18397 [R] KOG4347 GTPase-activating protein VRP 76 2e-13
Hs5902154 [R] KOG4347 GTPase-activating protein VRP 75 4e-13
Hs8922167 [U] KOG2058 Ypt/Rab GTPase activating protein 74 8e-13
Hs22056446 [U] KOG2058 Ypt/Rab GTPase activating protein 72 3e-12
At3g55020 [U] KOG2058 Ypt/Rab GTPase activating protein 72 3e-12
SPAC4G8.04 [U] KOG2058 Ypt/Rab GTPase activating protein 70 1e-11
CE29155 [U] KOG2058 Ypt/Rab GTPase activating protein 69 2e-11
Hs14916463 [R] KOG1093 Predicted protein kinase (contains TBC an... 67 9e-11
Hs11034851 [TR] KOG2222 Uncharacterized conserved protein contai... 66 2e-10
SPAC6F6.08c [U] KOG2058 Ypt/Rab GTPase activating protein 64 1e-09
CE10236 [TR] KOG2222 Uncharacterized conserved protein contains ... 63 1e-09
YOL112w [U] KOG2058 Ypt/Rab GTPase activating protein 61 5e-09
Hs18580214 [U] KOG2058 Ypt/Rab GTPase activating protein 61 5e-09
YNL293w [U] KOG2058 Ypt/Rab GTPase activating protein 60 1e-08
At5g24390 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 60 1e-08
7299972 [TR] KOG2222 Uncharacterized conserved protein contains ... 60 1e-08
7290543 [R] KOG1093 Predicted protein kinase (contains TBC and R... 60 1e-08
Hs22058425 [U] KOG2058 Ypt/Rab GTPase activating protein 59 2e-08
Hs22062568 [U] KOG2221 PDZ-domain interacting protein EPI64 cont... 58 6e-08
At5g52590 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 58 6e-08
YDL234c [T] KOG2197 Ypt/Rab-specific GTPase-activating protein G... 57 7e-08
7299317 [U] KOG2058 Ypt/Rab GTPase activating protein 57 7e-08
SPBC651.03c [T] KOG2595 Predicted GTPase activator protein 57 1e-07
At5g53570 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 56 2e-07
CE02529 [R] KOG1093 Predicted protein kinase (contains TBC and R... 55 4e-07
Hs21361637 [R] KOG4567 GTPase-activating protein 54 8e-07
Hs4758564_1 [R] KOG1102 Rab6 GTPase activator GAPCenA and relate... 54 1e-06
HsM12232451 [T] KOG2197 Ypt/Rab-specific GTPase-activating prote... 53 1e-06
At3g49350 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 53 1e-06
Hs21362084 [T] KOG2197 Ypt/Rab-specific GTPase-activating protei... 53 2e-06
SPAC1952.17c [R] KOG4567 GTPase-activating protein 52 2e-06
Hs20548703_1 [T] KOG2197 Ypt/Rab-specific GTPase-activating prot... 52 3e-06
SPAC23D3.03c [TR] KOG2223 Uncharacterized conserved protein cont... 51 5e-06
At3g59570 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 51 5e-06
>YPL249c [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 894
Score = 498 bits (1282), Expect = e-140
Identities = 295/733 (40%), Positives = 406/733 (55%), Gaps = 76/733 (10%)
Query: 8 KDDVKSTASNDAELPLDESENVEPSGDKIEIETEQPDVADAPANDGAPSANEIKETDVSF 67
K++ K A + E+ V E + + D A +AN+I +S
Sbjct: 142 KENEKVYADTKEVVSSPENREVTGKNSGGEKSSSSKFLDDESGTTTAANANDIS---ISS 198
Query: 68 AATEKKNNEDSPPITGAIEVKEEVA-----DEPVDSSTVESEAPDTVEVVNNETE----P 118
T ++++E+ I + EVA +E + + P T E +++ET P
Sbjct: 199 EVTPERSSEND---NNQIHITNEVAAGINLNENKEQKAAIEDGPVTAENLSSETARKVPP 255
Query: 119 IDTDKDSLSNESVIKSKQEILEQKIESFNNETKPPHLPPRDHIA-GEKPPLPSRSHVATS 177
I T +I K + + S T P LPPR ++A P LP R
Sbjct: 256 IPTQ--------IINEKGDNSSENEVSAIPTTSSPPLPPRQNVATSTSPKLPPRGKQREQ 307
Query: 178 LSGPVHFVPPPLSEEMKSPKFRAHFNQHKRSD----------------SSDFDLILNRFI 221
+ VPPPL EEMKS KFR +F + KR+ +++ +LI +R+
Sbjct: 308 PPKTKNAVPPPLEEEMKSEKFRKNFEETKRNSYHHVPLTGSKTAQLESTAEINLIASRYR 367
Query: 222 QNETELELRDDKEREHAKEGTKTLREEYDSLLDHA------------DKELVQYDWPFWS 269
+ L ++ RE +EG L+ + S L++ D+E+ + DW FW+
Sbjct: 368 KTSHHLNKEGEETRESLQEGQSFLKSTFTSFLENLSEYNEVENVNEEDREMFKIDWSFWT 427
Query: 270 KLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHE 329
++V++++ + ++ + LE V GIP Q+RGIIWQL+ +S + HE
Sbjct: 428 QVVNDYATVASNEPENLEAHVTNGIPPQIRGIIWQLMANSKSREMEDIYETLLDTECLHE 487
Query: 330 KAIKRDLSRTKFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFS 389
I+RDL RTKF+ E K +SL+ V+K YS+YDP VGYTQGMGFIA L++NCE E ++F
Sbjct: 488 ATIRRDLRRTKFVAEDKMESLYKVIKVYSVYDPDVGYTQGMGFIAAPLLINCENEAESFG 547
Query: 390 LLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFL 449
LL LMK YGLR+LFLPGMPGLML LYQFD LLEE+ P LYN LIR+GI STM+ATQWFL
Sbjct: 548 LLVGLMKNYGLRELFLPGMPGLMLMLYQFDRLLEEHSPSLYNRLIREGISSTMYATQWFL 607
Query: 450 TMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQ 509
T FAYKFPLEFVLRI DIV +EGIE +LKF++ LMLKN L+ L FD LLDFLK++LF
Sbjct: 608 TFFAYKFPLEFVLRIFDIVFVEGIEVLLKFAVNLMLKNEETLVKLRFDELLDFLKDELFN 667
Query: 510 HY----------------------ASKENPEEYDIDRFISDSLE-IKLTPLQLERYVKEY 546
+Y + + Y++D F+ D++ + +TPL L RY EY
Sbjct: 668 YYLMGNQDDASVVQMGLSNGNSFKGNDDGTFSYNVDLFVHDAMTGVYITPLTLRRYRGEY 727
Query: 547 DEIHKLETEKEQQYEEQRIKNRQLQKELKKLENDYSLLNREHITIANELIENRLRMETLQ 606
EIH+ E +KE YE RI+N QLQ+E +KLE+DYS+LN+E+I+ ANELI+NRL ME L
Sbjct: 728 VEIHEKEQKKEDHYESLRIQNHQLQREAQKLEHDYSILNKENISAANELIQNRLNMEMLL 787
Query: 607 XXXXXXXXXXXXXXXXXXRELYKQTLPNPDAEIP-TDLKADLNRTMERNLEVMDENQELR 665
E+ KQ LPNPDA +P DL+ DL RT+ RN EVM EN +L
Sbjct: 788 DEKNDLINTITDIKSQIEEEIRKQNLPNPDASLPKADLREDLERTISRNNEVMRENGQLE 847
Query: 666 TRLDELEKENYEL 678
R+ EL+ E EL
Sbjct: 848 ERITELQAEIDEL 860
>YMR192w [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 720
Score = 301 bits (771), Expect = 2e-81
Identities = 220/731 (30%), Positives = 357/731 (48%), Gaps = 58/731 (7%)
Query: 4 QVETKDDVKSTASNDAELPLDESENVEPSGDKIEIETEQPDVADAPANDGAPSANEIKET 63
Q + + D A D E+ + E + S +K+E+ T +A +N G+ + + E+
Sbjct: 20 QTQPEKDSDRIALRD-EISVPEGDEKAYSDEKVEMAT-----TNASSNFGSNESAKDGES 73
Query: 64 DVSF-----AATEKKNNEDSPPITGAIEVKEEVADEPVDSSTVESEAPDTVEVVNNETEP 118
+F A + K E+S T + S +E+E E + T P
Sbjct: 74 IGAFSNPHEALMQSKLREESQSKT--------ILPSDDLSQQLETEESKVEEALKRITSP 125
Query: 119 IDTDKDSLSNESVIKSKQEILEQKIESFNNETKP---PHLPPRDHIAGEKPPLPSRSHVA 175
+ ES K L + N+ P P LPPR + E L + A
Sbjct: 126 PLPPRADCIEESASALKSS-LPPVLAGNKNDQAPLDRPQLPPRQVVNAETLHLKAPHGNA 184
Query: 176 TSLSGPVHFV-------PPPLSEEMKSPKFRAHFNQHKRSDSSDFDLILNRFIQNETELE 228
T P V PP L +H + + +++ + N + +
Sbjct: 185 TPSKSPTSAVGNSSSSTPPTLPPRRIEDPLDLAAQKHFLASTFKRNMLFYKSEDNSIKCD 244
Query: 229 LRDDKEREHAKEGTKTLREEYDSLLDHADKELVQYDWPFWSKLVHNFSDIVKDDSKKLET 288
L DK + KE +K + + E+ + FW K++ ++ +I+ +D + L
Sbjct: 245 L--DKNILNLKEDSKKIN----------NNEIPEEVSSFWLKVIGDYQNILINDIETLHF 292
Query: 289 EVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHE-KAIKRDLSRTKFIPEGKT 347
++ +GIP R ++WQL++ + K +P + + + L +P
Sbjct: 293 QLSRGIPAAYRLVVWQLVSYAKSKSFDPIYETYLTEMAPFDVQEFENQLKMMDEVPSEYV 352
Query: 348 DSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPG 407
+ +VLKAY L+DP ++ + +I ++ CEEE AF LL +LMKVYGLR LFLP
Sbjct: 353 KRISNVLKAYLLFDPECEFSTDIAYIINMILDVCEEEANAFGLLVRLMKVYGLRLLFLPS 412
Query: 408 MPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDI 467
+ + Y+FD L+EE P+++NH++ +G+RS+MF +F T+F K P E RI D+
Sbjct: 413 ASEIDILCYKFDRLVEEFYPEIHNHMVEKGVRSSMFLPGFFTTLFQKKLPTEIQPRIGDM 472
Query: 468 VILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQHYASKENPEEYD------ 521
V LEGI+S+++ TL+ + +L+ + FD +L+ LK L Y + + D
Sbjct: 473 VFLEGIDSIMRILATLLSNSRDHLLKMGFDDMLELLKSGLLDAYIKQNDGTRGDTLLSNE 532
Query: 522 -IDRFISDS-LEIKLTPLQLERYVKEYDEIHKLETEKEQQYEEQRIKNRQLQKELKKLEN 579
+D+ + DS +++ +TP +++Y EY+EIH+L+ EKE QY+ KN LQK ++KLEN
Sbjct: 533 CMDKLLQDSMMKVAITPKTMKKYSSEYEEIHRLDNEKEVQYKSITEKNLHLQKHVRKLEN 592
Query: 580 DYSLLNREHITIANELIENRLRMETLQXXXXXXXXXXXXXXXXXXRELYKQTLPNPDAEI 639
DY+ LNREH+TIANEL++NRL +E++ E KQ L +
Sbjct: 593 DYTSLNREHVTIANELVKNRLNIESVLNENNGYKLQILDLKKKLDSEKKKQVL---GVYV 649
Query: 640 PTDLKADLNRTMERNLEVMDENQELRTRLDELEKENYELRT-GKTWTK-DATNPKGNRLG 697
P DLK DL TM++N +VMDEN +L+ R+ ELE+ E++T K T + +N K N LG
Sbjct: 650 PNDLKKDLEETMKKNTQVMDENLKLQDRISELERLIEEIKTANKNGTLFEYSNSKNNPLG 709
Query: 698 -NWA-FKSPWK 706
W+ FK +K
Sbjct: 710 AGWSGFKKVFK 720
>Hs19923325_1 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 707
Score = 197 bits (500), Expect = 6e-50
Identities = 138/458 (30%), Positives = 226/458 (49%), Gaps = 35/458 (7%)
Query: 251 SLLDHADKELVQYDWPFWSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSN 310
S L H +++ W W ++V+ + D+ K K+++ V KGIP R I+WQLL S+
Sbjct: 125 SNLSHLEED----SWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ 180
Query: 311 YKXXXXXXXXXXXXXSPHEKAIKRDLSRT----KFIPEGKT---DSLFSVLKAYSLYDPP 363
SP EK I+RD++RT F E + + LF+V+KAYSL D
Sbjct: 181 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE 240
Query: 364 VGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLE 423
VGY QG FI L++ EE +AF + KLM+ Y LR+LF P M L L +YQF+ +++
Sbjct: 241 VGYCQGSAFIVGLLLMQMPEE-EAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQ 299
Query: 424 ENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTL 483
E+ P+L+ H Q ++M+A+ WFLT+F FPL RI DI + EG+E + + L L
Sbjct: 300 EHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPVATRIFDIFMSEGLEIVFRVGLAL 359
Query: 484 MLKNSRNLIILSFDSLLDFLKEDLFQHYASKENPEEYD--IDRFISDSLEIKLTPLQLER 541
+ N L+ L + +L QH+ K P ++D D+ I + +++ ++++
Sbjct: 360 LQMNQAELMQLDMEGML--------QHF-QKVIPHQFDGVPDKLIQAAYQVQYNSKKMKK 410
Query: 542 YVKEYDEIHKLETEKEQQYEEQRIKNRQLQKELKKLENDYSLLNREH---ITIANELIEN 598
KEY I E E++ + + R +NR L++ ++ LE N + + EL++
Sbjct: 411 LEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQA 470
Query: 599 RLRMETLQXXXXXXXXXXXXXXXXXXRELYKQTLPNPDAEIPTDLKADLNRTMERNLEVM 658
RL Q ++ K+ PD L+ +L R E +
Sbjct: 471 RLSEAESQCALKEMQDKVL--------DIEKRNNSLPDENNIARLQEELIAVKLREAEAI 522
Query: 659 DENQELRTRLDELEKENYELRTGKTWTKDATNPKGNRL 696
+ELR ++ +LE E+++ +T + PK N +
Sbjct: 523 MGLKELRQQVKDLE-EHWQRHLARTTGRWKDPPKKNAM 559
>Hs12232373 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 997
Score = 194 bits (494), Expect = 3e-49
Identities = 154/554 (27%), Positives = 266/554 (47%), Gaps = 69/554 (12%)
Query: 174 VATSLSGPVHFVPPPLSEEMK--SPKFRAHFNQHKRSDSSDFDLILNRFIQNETELE--- 228
V T + PV F+ L +++ SP R + KRS + +F L L + Q E +
Sbjct: 342 VITEVQEPVRFL---LETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDT 398
Query: 229 ------LRDDKEREHAKE-GTKTLR------------------EEYDS---LLDHA---D 257
L + ERE K + ++R EE D+ LL +
Sbjct: 399 LYEVVCLESESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVS 458
Query: 258 KELVQYDWPFWSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSS-NYKXXXX 316
KE + W +L+ + + K+L + V G+P +RG +WQLL N
Sbjct: 459 KECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVE 518
Query: 317 XXXXXXXXXSPHEKAIKRDLSRT-------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQG 369
SP + AI RD++RT K DSL+ + KAYS+YD +GY QG
Sbjct: 519 KYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQG 578
Query: 370 MGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQL 429
F+A L+L+ EE QAFS+L K+M YGLR+LF L K YQ + L++E P L
Sbjct: 579 QSFLAAVLLLHMPEE-QAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDL 637
Query: 430 YNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSR 489
YNH + + + M+A+QWFLT+F KFPL V I+D+++ EGI + +L L+ +
Sbjct: 638 YNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKD 697
Query: 490 NLIILSFDSLLDFLKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEI 549
+L++ F+ L F + L + Y S+EN + + + + +K++ +L++Y KEY +
Sbjct: 698 DLLLTDFEGALKFFRVQLPKRYRSEENAK-----KLMELACNMKISQKKLKKYEKEYHTM 752
Query: 550 HKLETEKEQQYEEQRIKNRQLQKELKKLENDYSLLNREHITIANELIENRLRMETLQXXX 609
+ + ++E E +NR+LQ+ +LE +E+ +A+EL+ +++ +
Sbjct: 753 REQQAQQEDPIERFERENRRLQEANMRLE-------QENDDLAHELVTSKIALRKDLDNA 805
Query: 610 XXXXXXXXXXXXXXXRELY-----KQTLPNPDAEIPTDLKADLNRT---MERNLEVMDEN 661
++L K+ L A++ + +L++ +++N ++ +
Sbjct: 806 EEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIGDY 865
Query: 662 QELRTRLDE-LEKE 674
+++ ++L E LEK+
Sbjct: 866 KQICSQLSERLEKQ 879
>Hs18590199 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 794
Score = 190 bits (482), Expect = 7e-48
Identities = 126/439 (28%), Positives = 212/439 (47%), Gaps = 31/439 (7%)
Query: 251 SLLDHADKELVQYDWPFWSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSN 310
S L H +++ W W ++ + + + + K L+ + KGIP R I+WQLL S+
Sbjct: 77 SNLSHLEEDT----WILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSAT 132
Query: 311 YKXXXXXXXXXXXXXSPHEKAIKRDLSRTKFIPEGK---------TDSLFSVLKAYSLYD 361
SP EK I+RD++RT PE + + LF+V+KAYSL D
Sbjct: 133 DMPVKNQYSELLKMSSPCEKLIRRDIART--YPEHEFFKGQDSLGQEVLFNVMKAYSLVD 190
Query: 362 PPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTL 421
VGY QG FI L++ EE +AF + +LM+ Y LR+LF P M L L +YQF+ +
Sbjct: 191 REVGYCQGSAFIVGLLLMQMPEE-EAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYM 249
Query: 422 LEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSL 481
L+E P L H Q ++M+A+ WFLT+F FPL R+ DI + EG+E + + L
Sbjct: 250 LQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGL 309
Query: 482 TLMLKNSRNLIILSFDSLLDFLKEDLFQHYASKENPEEYDI--DRFISDSLEIKLTPLQL 539
L+ N L+ L + + Y + P ++D D+ + + ++K P ++
Sbjct: 310 ALLQVNQAELMQLDMEGM---------SQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKM 360
Query: 540 ERYVKEYDEIHKLETEKEQQYEEQRIKNRQLQKELKKLENDYSLLNREHITIANELIENR 599
+R KEY + E E++ + + R +NR L++ ++ LE + R N +I+
Sbjct: 361 KRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEK--GQVTRAQEAEENYVIKRE 418
Query: 600 LRMETLQXXXXXXXXXXXXXXXXXXRELYKQTLPNPDAEIPTDLKADLNRTMERNLEVMD 659
L + Q +E +Q P + + L+ +L ++ R E +
Sbjct: 419 LAVVRQQCSSAAEDLQKAQSTIRQLQE--QQENPRLTEDFVSHLETELEQSRLRETETLG 476
Query: 660 ENQELRTRLDELEKENYEL 678
+E++ ++ ++EK N L
Sbjct: 477 ALREMQDKVLDMEKRNSSL 495
>SPAC26F1.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1031
Score = 184 bits (467), Expect = 4e-46
Identities = 121/401 (30%), Positives = 195/401 (48%), Gaps = 30/401 (7%)
Query: 298 VRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEKAIKRDLSRTKFIPE------------- 344
V ++W+ ++S +KAI++DL RT F PE
Sbjct: 615 VHTVVWKTISSWTSYDYEMQYSSLSIKNCDSDKAIRKDLDRT-FAPEILSHFFSNRQQLE 673
Query: 345 ------GKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVY 398
T +L VL++ ++ P VGYTQGM +IA L+++ QAF+LL L K Y
Sbjct: 674 PTDNIAESTANLHRVLRSLAIVLPQVGYTQGMSWIAGALLMHLPAP-QAFALLVFLFKNY 732
Query: 399 GLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPL 458
L+++F M GL L+QF L+E+ P L H RQ I++ +A++WFLT+FAYKFPL
Sbjct: 733 HLQNIFSSEMRGLSRVLHQFTRLVEDYMPSLAIHFKRQDIKTCSYASEWFLTLFAYKFPL 792
Query: 459 EFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQHYASKENPE 518
E V + DI+ L G + F L L+ + +L+ L+ D L+ +LKED+F + + E
Sbjct: 793 EVVAHLYDILFLYGPGILFNFGLALLSHSQESLLKLNMDRLISYLKEDIFLAFKETQEGE 852
Query: 519 EYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLETEKEQQYEEQRIKNRQLQKELKKLE 578
YD F+ + ++ P L+RY EYD + K E E + EE R +++ L + L
Sbjct: 853 NYDTSLFVKTAFSFEIQPDVLDRYGNEYDILLKSEHELDSSLEEMRNRHKSLNEHFIMLS 912
Query: 579 NDYSLLNREHITIANELIENRLRMETLQXXXXXXXXXXXXXXXXXXRELYKQTLPNPDAE 638
+ + L EH ++ L++ ++ ++ +L KQ +E
Sbjct: 913 DSMANLQVEHENMSALLLKEKMYLKN----QTVEQASLKSEIASLNSQLAKQ-----KSE 963
Query: 639 IPTDLKADLNRTMERNLEVMDENQELRTRLDELEKENYELR 679
I + D+ + NLE+M E+Q L + EK+ E +
Sbjct: 964 IEQAFQGDMEAIIAENLEIMVESQSLEDEIFRKEKQLAETK 1004
>CE27153 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1136
Score = 180 bits (456), Expect = 8e-45
Identities = 125/417 (29%), Positives = 210/417 (49%), Gaps = 50/417 (11%)
Query: 268 WSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSS-NYKXXXXXXXXXXXXXS 326
W +L+ N+ D D +K+ V GIP ++RG +WQLL+++ +
Sbjct: 436 WDQLIENW-DQQSDRPQKISELVLDGIPDKLRGRVWQLLSNAIDQPDLVEKYHIFLSQPC 494
Query: 327 PHEKAIKRDLSRT----KFIPEGK---TDSLFSVLKAYSLYDPPVGYTQGMGFIATTLIL 379
P E+ I RD+ RT + E + SL+ + K YSLYD V Y QG+ F+A +L+L
Sbjct: 495 PSEQVIMRDIHRTFPAHDYFKESQGKGQQSLYKISKVYSLYDEEVSYCQGLSFLAASLLL 554
Query: 380 NCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIR 439
+ EE QAF L K+M YGLRDLF G L L+ +Q LL++ P L +HL GI
Sbjct: 555 HMPEE-QAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQLTALLKDYIPDLSHHLEHIGIE 613
Query: 440 STMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSL 499
+ M+A+QWFLT+F KFPL+ V I+D+ + +G+ ++ SL L+ +L+ L F+
Sbjct: 614 THMYASQWFLTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLDDAKTDLLQLDFEGT 673
Query: 500 LDFLKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLETEKEQQ 559
L + + L + Y + E I +++ +L +LE Y EY I +LE E E
Sbjct: 674 LKYFRVSLPRKYRT-----EASTKCLIHKAVKFRLNHSKLEVYENEYKRIKELERENEDP 728
Query: 560 YEEQRIKNRQLQKELKKLENDYSLLNREHITIANELIENRLRMETLQXXXXXXXXXXXXX 619
+++KE+ + + + L RE+ +A+EL+ +++ +
Sbjct: 729 V-------LRMEKEIGRHQANTLRLERENDDLAHELVTSKIEL----------------- 764
Query: 620 XXXXXRELYKQTLPNPDAEIPTDLKADLNRTMERNLEVMDENQELRTRLDELEKENY 676
++ L + +I T A + R +N+++++EN+ L +++ KE Y
Sbjct: 765 ---------RRKLDVAEDQIETSANA-IERLTRQNMDILEENKNLMREYEQI-KEMY 810
>CE27154 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1140
Score = 177 bits (449), Expect = 5e-44
Identities = 125/421 (29%), Positives = 209/421 (48%), Gaps = 54/421 (12%)
Query: 268 WSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSS-----NYKXXXXXXXXXX 322
W +L+ N+ D D +K+ V GIP ++RG +WQLL++ +
Sbjct: 436 WDQLIENW-DQQSDRPQKISELVLDGIPDKLRGRVWQLLSNVRILAIDQPDLVEKYHIFL 494
Query: 323 XXXSPHEKAIKRDLSRT----KFIPEGK---TDSLFSVLKAYSLYDPPVGYTQGMGFIAT 375
P E+ I RD+ RT + E + SL+ + K YSLYD V Y QG+ F+A
Sbjct: 495 SQPCPSEQVIMRDIHRTFPAHDYFKESQGKGQQSLYKISKVYSLYDEEVSYCQGLSFLAA 554
Query: 376 TLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIR 435
+L+L+ EE QAF L K+M YGLRDLF G L L+ +Q LL++ P L +HL
Sbjct: 555 SLLLHMPEE-QAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQLTALLKDYIPDLSHHLEH 613
Query: 436 QGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILS 495
GI + M+A+QWFLT+F KFPL+ V I+D+ + +G+ ++ SL L+ +L+ L
Sbjct: 614 IGIETHMYASQWFLTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLDDAKTDLLQLD 673
Query: 496 FDSLLDFLKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLETE 555
F+ L + + L + Y + E I +++ +L +LE Y EY I +LE E
Sbjct: 674 FEGTLKYFRVSLPRKYRT-----EASTKCLIHKAVKFRLNHSKLEVYENEYKRIKELERE 728
Query: 556 KEQQYEEQRIKNRQLQKELKKLENDYSLLNREHITIANELIENRLRMETLQXXXXXXXXX 615
E +++KE+ + + + L RE+ +A+EL+ +++ +
Sbjct: 729 NEDPV-------LRMEKEIGRHQANTLRLERENDDLAHELVTSKIEL------------- 768
Query: 616 XXXXXXXXXRELYKQTLPNPDAEIPTDLKADLNRTMERNLEVMDENQELRTRLDELEKEN 675
++ L + +I T A + R +N+++++EN+ L +++ KE
Sbjct: 769 -------------RRKLDVAEDQIETSANA-IERLTRQNMDILEENKNLMREYEQI-KEM 813
Query: 676 Y 676
Y
Sbjct: 814 Y 814
>7292646 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 803
Score = 175 bits (443), Expect = 2e-43
Identities = 113/401 (28%), Positives = 211/401 (52%), Gaps = 29/401 (7%)
Query: 210 SSDFDLILNRFIQN---ETELELRDDKEREHAKEGTKTLREEYDSLLDHADKELVQYDWP 266
+S+ DL+ N E++ + + H+++ + T + S + +E + W
Sbjct: 33 TSEMDLLAKLEAANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEEDI---WT 89
Query: 267 FWSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXS 326
W+ +++++ +K + + V +GIP R I+WQ L+ ++ S
Sbjct: 90 TWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGAS-DGDKKQYAEYIKATS 148
Query: 327 PHEKAIKRDLSRT----KFIPEGK---TDSLFSVLKAYSLYDPPVGYTQGMGFIATTLIL 379
EK I+RD++RT +F E ++LF+V+KAYSL+D VGY QG GFI L++
Sbjct: 149 ACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLM 208
Query: 380 NCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIR 439
EE +AF++L ++M+ + +R +F P M L L +YQ + L++E P ++ H +QG +
Sbjct: 209 QMPEE-EAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQ 267
Query: 440 STMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSL 499
+TM+A+ WFLT++ + RIMD+ + EG+E + K +L L+L L+ L +++
Sbjct: 268 TTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAM 327
Query: 500 LDFLKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLETEKEQQ 559
L F +++L E D++ F + + IKL ++++ KEY ++ K E
Sbjct: 328 LKFFQKEL-------PGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKE------ 374
Query: 560 YEEQRIKNRQLQKELKKLENDYSLLNREHITIANELIENRL 600
+E+ + R+L++E L+ LL E +A+ L+ ++
Sbjct: 375 -QEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQV 414
>CE07531 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 480
Score = 165 bits (417), Expect = 3e-40
Identities = 97/314 (30%), Positives = 169/314 (52%), Gaps = 16/314 (5%)
Query: 254 DHADKELVQYDWPFWSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKX 313
+H+ +E + W W +L+ N+ VK ++ V +GIP R I WQ L++++
Sbjct: 116 EHSPEEDEEDLWSVWGELILNWEIEVKKRPNYIKDLVKRGIPQHFRMIAWQNLSNASVSS 175
Query: 314 XXXXXXXXXXXXSPHEKAIKRDLSRT----KFIPEGKTDS--LFSVLKAYSLYDPPVGYT 367
S +EK I+RD+ RT F +G+ LF+V+KAYS++D VGY
Sbjct: 176 VHDLYSDYMRQSSVYEKVIQRDIPRTYPELDFFKDGERGQSLLFNVIKAYSVHDKEVGYC 235
Query: 368 QGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDP 427
QG FI L+L EE +AF++L LM+ Y LR+L+ P M L L ++Q + L+++ P
Sbjct: 236 QGSAFIVGLLLLQMPEE-EAFAVLVSLMENYRLRELYKPTMTDLGLCMFQLECLVQDQMP 294
Query: 428 QLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKN 487
LY H G ++M+A+ WFLT+F PL+ RIMD ++EG++ + S+ ++ +
Sbjct: 295 DLYTHFNNMGFDTSMYASSWFLTLFTTTMPLDIANRIMDCFLVEGMDFIFCISIAILQQA 354
Query: 488 SRNLIILSFDSLLDFLKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYD 547
L+ L + +L + + ++ + Y E+D D + + +++L +++R K+Y
Sbjct: 355 RIELLRLDMEGMLKYFQREVRERY-------EFDADLLFTVANQVQLNAKRMKRLEKDY- 406
Query: 548 EIHKLETEKEQQYE 561
+ K E+E+ E
Sbjct: 407 -LTKRTKEQEEAVE 419
>7295111 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1194
Score = 157 bits (396), Expect = 7e-38
Identities = 112/387 (28%), Positives = 194/387 (49%), Gaps = 28/387 (7%)
Query: 217 LNRFIQNETELELRDDKEREHAKEGTKTLREEYDSLLDHADKELVQYDWPFWSKLVHNFS 276
L+R +++ + + DD +++ +G + L S K+ Q W ++ +
Sbjct: 583 LSRIVRSSSIASIEDDCPSDYSSDGDEPLL----SGTGEVSKDCSQDTLDEWDPILREWD 638
Query: 277 DIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPH-EKAIKRD 335
+ K L V G+P +R IWQ L + + E I+RD
Sbjct: 639 S--EKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETVIQRD 696
Query: 336 LSRT-------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAF 388
+ RT K I D+LF V KAY+++D VGY QG+ FIA +L+L+ EE AF
Sbjct: 697 IHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEE-DAF 755
Query: 389 SLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWF 448
+L LM YGLRDL+ G L L+LYQ + L+++ P+L+ H GI + M+A+QWF
Sbjct: 756 CVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWF 815
Query: 449 LTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLF 508
LT++ +FPL FV ++D+ +L+G+ + + ++TL+ +L L F+ +L + + L
Sbjct: 816 LTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLP 875
Query: 509 QHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLETE-KEQQYEEQRIKN 567
+ S + + + E K+ L K+Y+E L+ + KE+ +E +I
Sbjct: 876 KKCRSSSQAR-----KVMKQACERKIKKL------KQYEEEFLLKKQHKERLEKEAQIYE 924
Query: 568 RQLQKELKKLENDYSLLNREHITIANE 594
+ +E +K++ + LN++ +T A E
Sbjct: 925 NRFGEERRKMQAEIDALNKQ-LTSAKE 950
>Hs7662198 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 1299
Score = 148 bits (373), Expect = 3e-35
Identities = 120/402 (29%), Positives = 199/402 (48%), Gaps = 43/402 (10%)
Query: 227 LELRDDKEREHAKEGTKTLREEYDSLLDHADKELVQYDWPF-WSKLVHNFSDIVKDDSKK 285
L LR +KE + + ++ + LD+ + Q + W K + N ++ D +
Sbjct: 852 LLLRMEKENQKLEGASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMED 911
Query: 286 LETEVGKGIPTQVRGIIWQLLT---------SSNYKXXXXXXXXXXXXXSPHEKAIKRDL 336
+ T + +G+P RG IWQ L + + + + AI DL
Sbjct: 912 IHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDL 971
Query: 337 SRT--------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAF 388
RT + G+ SLF++LKAYSL D VGY QG+ F+A L+L+ EE QAF
Sbjct: 972 GRTFPTHPYFSVQLGPGQL-SLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEE-QAF 1029
Query: 389 SLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWF 448
+L LM G R + P M L +++YQ LL + LYNHL I +++A WF
Sbjct: 1030 EMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWF 1089
Query: 449 LTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIIL---SFDSLLDFLKE 505
LT+FA +F L FV R+ DI+ L+G E + K +L+L+ +S+ +I+ SF+++++FLK
Sbjct: 1090 LTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLL--SSQETLIMECESFENIVEFLKN 1147
Query: 506 DLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLETE-KEQQYEEQR 564
L S ++++ I+ E+ ++ QL Y EY H L+ E +E Y
Sbjct: 1148 TLPDMNTS-------EMEKIITQVFEMDISK-QLHAYEVEY---HVLQDELQESSY---- 1192
Query: 565 IKNRQLQKELKKLENDYSLLNREHITIANELIENRLRMETLQ 606
+ + + L+KLE S L R+++ + +L +++ L+
Sbjct: 1193 --SCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALE 1232
>Hs20532509 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 937
Score = 147 bits (370), Expect = 7e-35
Identities = 134/468 (28%), Positives = 218/468 (45%), Gaps = 68/468 (14%)
Query: 163 GEKPPLPSRSHVATSLSGPVHFVPPPLSEEMKSPKFRAHFNQHKRSDSSDFDLILNRFIQ 222
GE PP V GP F PPP ++ S + R +L +Q
Sbjct: 458 GELPPRSPLEPVCED--GP--FGPPPEEKKRTSRELR--------------ELWQKAILQ 499
Query: 223 NETELELRDDKEREHAKEG---TKTLREEYDSLLDHADKELVQYDWPFWSKLVHNFS-DI 278
L + + ++ A E K L+ +Y+ + KE+ W K++
Sbjct: 500 QILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCL-KEVTTV----WEKMLSTPGRSK 554
Query: 279 VKDDSKKLETEVGKGIPTQVRGIIWQLLTS---------SNYKXXXXXXXXXXXXXSPHE 329
+K D +K+ + VG+G+P RG IW+ L S + + +
Sbjct: 555 IKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQ 614
Query: 330 KAIKRDLSRT--------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNC 381
AI DL RT + G+ SL+++LKAYSL D VGY QG+ F+A L+L+
Sbjct: 615 HAILIDLGRTFPTHPYFSAQLGAGQL-SLYNILKAYSLLDQEVGYCQGLSFVAGILLLHM 673
Query: 382 EEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRST 441
EE +AF +L LM GLR + P M L +++YQ LL + LYNHL I +
Sbjct: 674 SEE-EAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPS 732
Query: 442 MFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIIL---SFDS 498
++A WFLTMFA +FPL FV R+ D++ L+G E + K +L+L+ S +IL + ++
Sbjct: 733 LYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLL--GSHKPLILQHENLET 790
Query: 499 LLDFLKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLETEKEQ 558
++DF+K L N +++ I+ E+ + QL+ Y EY H L+ E+
Sbjct: 791 IVDFIKSTL-------PNLGLVQMEKTINQVFEMDIAK-QLQAYEVEY---HVLQ---EE 836
Query: 559 QYEEQRIKNRQLQKELKKLENDYSLLNREHITIANELIENRLRMETLQ 606
+ + + Q + KLE S L ++++ + +L R+++L+
Sbjct: 837 LIDSSPLSDNQ---RMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLE 881
>7296688 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 1379
Score = 144 bits (363), Expect = 5e-34
Identities = 122/462 (26%), Positives = 221/462 (47%), Gaps = 61/462 (13%)
Query: 215 LILNRFIQNETELELRDDKEREHAKEGTKTLREEYDSLLDHADKELVQYDWPFWSKLVHN 274
++LNR ETE + ++ E+ K ++ +Y+ ++ DK+L++ W +++
Sbjct: 674 IMLNRM---ETENAMLQARQNENE---LKRIKLDYEEIVP-CDKQLIER----WEQIIER 722
Query: 275 FSDIV--KDDSKKLETEVGKGIPTQVRGIIWQLLTSSN-----------YKXXXXXXXXX 321
S + K D K L + G+P RG +W L + +
Sbjct: 723 NSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHML 782
Query: 322 XXXXSPHEKAIKRDLSRTKFIPEGKTD-------SLFSVLKAYSLYDPPVGYTQGMGFIA 374
+ H+ AI DL RT + D SLF++LKAYS+ DP +GY QG+GFI
Sbjct: 783 LKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFIC 842
Query: 375 TTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLI 434
L+L+C+E +F LL LM +R +LP M L+LYQ L++++ P LY L
Sbjct: 843 GVLLLHCDEA-NSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLD 901
Query: 435 RQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIIL 494
+ + T++A W LT+F+ +FPL FV R+ D++ LE + + KF++ L+ + + L+
Sbjct: 902 QNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAK 961
Query: 495 -SFDSLLDFLKEDL--FQHYASKENPE---EYDIDRFISDSLEIKLTPLQLERYVKEYDE 548
+F+ ++D+LK + +H ++ + DI + +++ +++ LQ E
Sbjct: 962 DNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAE-YKVEYNVLQ-EEITTTNHH 1019
Query: 549 IHKLETEKEQ-QYEEQRIKNRQLQKELKKLENDYSLLNREHITIANELIENRLRMETLQX 607
+ L EK Q Q+ EQ++ + Q + +LE S + T+ +++ L ++TL
Sbjct: 1020 LEMLNREKTQNQHLEQQL--QFAQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTL-- 1075
Query: 608 XXXXXXXXXXXXXXXXXRELYKQTLPNPDAEIPTDLKADLNR 649
R + + NPD E+P +++ L +
Sbjct: 1076 ----------------GRYVGQLVEHNPDLELPNEVRRMLQQ 1101
>At5g15930 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 356
Score = 133 bits (334), Expect = 1e-30
Identities = 90/255 (35%), Positives = 136/255 (53%), Gaps = 20/255 (7%)
Query: 268 WSKLV----HNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSN---YKXXXXXXXX 320
W K++ ++ V+ ++ + KGIP +RG++WQL++ S
Sbjct: 56 WRKMIGTGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNPGVYVQL 115
Query: 321 XXXXXSPHEKAIKRDLSRT--------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGF 372
S E I RD+SRT K G+ SL++VLKAYS+YD VGY QGMGF
Sbjct: 116 VIYETSASELDIIRDISRTFPSHVFFQKRHGPGQR-SLYNVLKAYSVYDRDVGYVQGMGF 174
Query: 373 IATTLILNCEEEWQAFSLLTKLMK--VYG-LRDLFLPGMPGLMLKLYQFDTLLEENDPQL 429
IA L+L EE AF LL L+K V+ + L+ G+P + L QFD L+ E P+L
Sbjct: 175 IAGLLLLYMSEE-DAFWLLVALLKGAVHSPIEGLYQAGLPLVQQYLLQFDQLVRELMPKL 233
Query: 430 YNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSR 489
H ++ I +M+A+QWF+T+F+Y P LRI D+ + EG++ + K L L+
Sbjct: 234 GEHFTQEMINPSMYASQWFITVFSYSLPFHSALRIWDVFLAEGVKIVFKVGLALLKHCHD 293
Query: 490 NLIILSFDSLLDFLK 504
+L+ L F+ L+ L+
Sbjct: 294 DLLKLPFEELMHALR 308
>At3g02460 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 304
Score = 131 bits (329), Expect = 4e-30
Identities = 91/269 (33%), Positives = 141/269 (51%), Gaps = 23/269 (8%)
Query: 234 EREHAKEGTKTLREEYDSLLDHADKELVQYDWPFWSKLV----HNFSDIVKDDSKKLETE 289
++EHA + + + S DH +E W K++ ++ V+ +
Sbjct: 28 KQEHANSPERFSKSKTTSSTDHDREERKVRKW---RKMIGVGGSDWKHYVRRKPNVVRRR 84
Query: 290 VGKGIPTQVRGIIWQLLTSSN---YKXXXXXXXXXXXXXSPHEKAIKRDLSRT------- 339
+ KGIP +RG++WQL++ S S E I RD+SRT
Sbjct: 85 IRKGIPDCLRGLVWQLISGSRDLLLMNPGVYEQLVIYETSASELDIIRDISRTFPSHVFF 144
Query: 340 -KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMK-- 396
K G+ SL++VLKAYS+YD VGY QGMGFIA L+L EE AF LL L+K
Sbjct: 145 QKRHGPGQR-SLYNVLKAYSVYDRDVGYVQGMGFIAGLLLLYMSEE-DAFWLLVALLKGA 202
Query: 397 VYG-LRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYK 455
V+ + L+ G+P + L+Q ++L++E P+L H ++ I +M+A+QWF+T+F+Y
Sbjct: 203 VHAPMEGLYHAGLPLVQQYLFQLESLVKELIPKLGEHFTQEMINPSMYASQWFITVFSYS 262
Query: 456 FPLEFVLRIMDIVILEGIESMLKFSLTLM 484
FP LRI D+ + EG++ + K L L+
Sbjct: 263 FPFPLALRIWDVFLSEGVKIVFKVGLALL 291
>7303241 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 457
Score = 108 bits (269), Expect = 4e-23
Identities = 83/338 (24%), Positives = 157/338 (45%), Gaps = 32/338 (9%)
Query: 268 WSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTS-----SNYKXXXXXXXXXX 322
W K+++ + KL V KGIP +VR + W L +N
Sbjct: 82 WMKMLNQWPP----PQDKLHKRVYKGIPDRVRMVAWNKLLDIQQSINNNAGVYLRMLQLA 137
Query: 323 XXXSPHEKAIKRDLSRT-------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIAT 375
S + I D++R + K SLF+VL AYS+Y+ +GY QGM +A
Sbjct: 138 RKYSTETRQIDADVNRQFRDNLAFRERYSVKQCSLFNVLNAYSIYNSELGYCQGMACVAG 197
Query: 376 TLILNCEEEWQAFSLLTKLM--KVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHL 433
L+L EE +AF L L+ + YG+ LF+ G P L + D ++ + +L+ H
Sbjct: 198 VLLLYLHEE-EAFWALNTLITDQKYGMHGLFIEGFPKLTRFIDHHDRIMSKIMRKLHKHF 256
Query: 434 IRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLII 493
+ + + ++A +WF +F + P LR+ DI +L+G +L ++T++ + L+
Sbjct: 257 TKHNVDALLYAIKWFFVVFVERVPFSLSLRVWDIFMLDGDRVILSMAITILYLHKDELLR 316
Query: 494 L-SFDSLLDFLKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKL 552
L D+++++L+ L +++ ++ ++R + ++KL V + ++
Sbjct: 317 LKDMDAIIEYLQVRLHKNFGYSDDDAIQALERVMKKLKDLKLD-------VPPPAKSNEF 369
Query: 553 ETEKEQQYEEQRIKNRQLQKELKKLENDYSLLNREHIT 590
T K + E ++K++ + NDY+ ++ IT
Sbjct: 370 PTRKLGDFVE-----ADMEKKIGRRRNDYTDAEKQVIT 402
>Hs7661864 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 828
Score = 107 bits (266), Expect = 8e-23
Identities = 89/322 (27%), Positives = 146/322 (44%), Gaps = 34/322 (10%)
Query: 268 WSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTS-----SNYKXXXXXXXXXX 322
W K++ + +++K + KGIP Q+RG +W LL +
Sbjct: 77 WLKMLKGWEKY--KNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRA 134
Query: 323 XXXSPHEKAIKRDLSRT-------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIAT 375
SP + I D++RT + K SLF VL AYS+Y+ VGY QGM I
Sbjct: 135 RGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITA 194
Query: 376 TLILNCEEEWQAFSLLTKLMK--VYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHL 433
L++ EE AF L KL + + F+ G P L+ + +L + +L HL
Sbjct: 195 LLLMYMNEE-DAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHL 253
Query: 434 IRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLII 493
Q I ++ + +WF F + P LRI DI I EG + S T++ + ++L+
Sbjct: 254 DSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMK 313
Query: 494 LSFDSLLDFLKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLE 553
LS + L++F +E L + + + D F+ + L+I +T L+ + + E
Sbjct: 314 LSMEELVEFFQETLAKDF--------FFEDDFVIEQLQISMTELKRAK-------LDLPE 358
Query: 554 TEKEQQYEEQRIKNRQLQKELK 575
KE +Y ++ + QL EL+
Sbjct: 359 PGKEDEYPKKPL--GQLPPELQ 378
>Hs13994322 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 508
Score = 102 bits (254), Expect = 2e-21
Identities = 78/267 (29%), Positives = 119/267 (44%), Gaps = 23/267 (8%)
Query: 234 EREHAKEGTKTLREEYDSLLDHADKELVQYDWPFWSKLVHNFSDIVKDDSKKLETEVGKG 293
ER K G + + L+ E+++ W +++N+ + KK+ KG
Sbjct: 52 ERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKG 111
Query: 294 IPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEK----AIKRDLSRT-----KFIPE 344
IP +RG WQ L+ K SP + I+RDL R F+
Sbjct: 112 IPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSR 171
Query: 345 GK--TDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRD 402
G LF VLKAY+LY P GY Q IA L+++ E QAF L ++ + Y
Sbjct: 172 GGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAE-QAFWCLVQICEKY---- 226
Query: 403 LFLPGMPGLMLKLYQFD-----TLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFP 457
LPG L+ Q D +LL++ P + HL RQ I ++ T+WF+ F+ P
Sbjct: 227 --LPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLP 284
Query: 458 LEFVLRIMDIVILEGIESMLKFSLTLM 484
VLR+ D+ EG++ + + L L+
Sbjct: 285 WSSVLRVWDMFFCEGVKIIFRVGLVLL 311
>CE28983 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1005
Score = 99.4 bits (246), Expect = 2e-20
Identities = 68/239 (28%), Positives = 119/239 (49%), Gaps = 16/239 (6%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQLLTSSNY-----KXXXXXXXXXXXXXSPHEKAIKRDLS 337
SKK+E + KGIP ++R +IW L + + S K I D++
Sbjct: 502 SKKMEDRIWKGIPEKLRIVIWPRLLGAERLKHERRDVYAELLLRARLVSKDIKQIDLDIN 561
Query: 338 RT-------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSL 390
RT + + K SL +VL AYS+++ VGY QGM IA ++ +EE AF
Sbjct: 562 RTYRDHLAFRKRYDVKQKSLLNVLAAYSMFNTEVGYCQGMSQIAALFLMYLDEE-DAFWS 620
Query: 391 LTKLM--KVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWF 448
L +LM + + F+PG P L F +L++ P++Y HL +Q I ++ T+W+
Sbjct: 621 LHQLMVSPKHTMHGFFVPGFPKLQRYEEHFKRVLKKYKPRVYKHLEKQDI-PYIYLTKWW 679
Query: 449 LTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDL 507
F + P LR+ D+ ++EG ++ + +M + +N+ + +S ++F++ D+
Sbjct: 680 FGCFLDRVPFSLALRLWDVFLVEGDCILIAMAYNIMKMHEKNVRKHNMESFMEFIQNDI 738
>YGR100w [R] KOG4347 GTPase-activating protein VRP
Length = 950
Score = 98.6 bits (244), Expect = 3e-20
Identities = 75/306 (24%), Positives = 142/306 (45%), Gaps = 22/306 (7%)
Query: 293 GIPTQVRGIIWQLLTSSNY----------KXXXXXXXXXXXXXSPHEKAIKRDLSR-TKF 341
G+P ++RG IW+L + + Y + EK +KR L + +
Sbjct: 244 GVPNRMRGEIWELCSGAMYMRYANSGEYERILNENAGKTSQAIDEIEKDLKRSLPEYSAY 303
Query: 342 IPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLR 401
E L +VL AYS +P VGY Q M + ++ EE QAF L L +Y +
Sbjct: 304 QTEEGIQRLRNVLTAYSWKNPDVGYCQAMNIVVAGFLIFMSEE-QAFWCLCNLCDIY-VP 361
Query: 402 DLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFV 461
+ M G +L F++ +E+ P L+ ++++ I+ ++ + WFL++F PLE+
Sbjct: 362 GYYSKTMYGTLLDQRVFESFVEDRMPVLWEYILQHDIQLSVVSLPWFLSLFFTSMPLEYA 421
Query: 462 LRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQHYASKENPEEYD 521
+RIMDI + G ++ + +L ++ N+ +++ D + + + FQ +P+ D
Sbjct: 422 VRIMDIFFMNGSITLFQVALAVLKINADDILQADDDGMFIAIIKHYFQTLGQSAHPDSSD 481
Query: 522 ID-RFISDSLEIKLTPLQLERYVKEYDEIHKLETEKEQQYEE---QRIKNRQLQKELKKL 577
I R I+ E+ +T + + E +H +YE+ Q I+ + +L+ +
Sbjct: 482 IKYRQITKFQELLVTAFKEFSVISEEMAMH-----ARHKYEKGIFQNIETFMKRTQLRHM 536
Query: 578 ENDYSL 583
++L
Sbjct: 537 PKTFNL 542
>7299471 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 363
Score = 97.8 bits (242), Expect = 5e-20
Identities = 80/289 (27%), Positives = 133/289 (45%), Gaps = 26/289 (8%)
Query: 268 WSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSP 327
W ++ N+S + + KK+ KGIP VR W L+ + P
Sbjct: 52 WLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKP 111
Query: 328 HE----KAIKRDLSRT-----KFIPEGKTDS--LFSVLKAYSLYDPPVGYTQGMGFIATT 376
+ IK+D R F+ E K LF+VLKAYS+Y+P VG+ Q IA
Sbjct: 112 GNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAF 171
Query: 377 LILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQ 436
L+++ E AF + + VY L+D F+PG+ + + LL++ P +Y HL +
Sbjct: 172 LLMHLPAE-DAFWVFVSVCDVY-LQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKH 229
Query: 437 GIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLM-LKNSRNLIILS 495
+ ++ T WFL P E +LR+ D + EGI + K +L ++ SR+ + +
Sbjct: 230 KVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKT 289
Query: 496 FDSLLDFLKEDLFQHYASKENPEEYDI-DRFISDS---LEIKLTPLQLE 540
L + L A +PEE+ + + FI ++ L +++ Q+E
Sbjct: 290 CTGLCETL--------AVLRSPEEHIVEEEFIINNMMRLNLRVEDFQIE 330
>SPBC215.01 [R] KOG4347 GTPase-activating protein VRP
Length = 827
Score = 94.4 bits (233), Expect = 5e-19
Identities = 73/311 (23%), Positives = 150/311 (47%), Gaps = 21/311 (6%)
Query: 294 IPTQVRGIIWQLLTSSNY------KXXXXXXXXXXXXXSPHEKAIKRDLSRT-----KFI 342
+P ++RG IW+L + S Y S + I++DL R+ +
Sbjct: 221 LPNKLRGEIWELTSGSMYFRLENSDEYDHLLKVYSGQTSFSLEEIEKDLGRSLPEYPAYQ 280
Query: 343 PEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRD 402
E ++L +VL A+S + VGY Q M +A L+++C EE Q F L+ K+ + Y +
Sbjct: 281 NEEGINALRNVLVAFSWKNQEVGYCQAMNIVAAALLIHCTEE-QTFFLMHKICEDY-IPG 338
Query: 403 LFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVL 462
+ M G ++ +++L++ + P L+ H + + I+ ++ + WFL++F PL +
Sbjct: 339 YYSKTMYGTLIDQQVYESLVQRSMPNLHAHFVSKDIQLSIISLPWFLSLFLCTMPLPYAF 398
Query: 463 RIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQHYASKENPEEYDI 522
R++D LEG + + + ++ N ++ + D++L + ++ F K +
Sbjct: 399 RLLDFFFLEGPRVLFQIGMAILYDNEAEIMKATEDTMLISILKNYFSSLGDKAYKDA--T 456
Query: 523 DRFISDSLEIKLTPLQLERYVKEYDEIHKL-ETEKEQQYE--EQRIKNRQLQKELKKLEN 579
D+ ++ + +L L + + K H L E E+++ YE I++ + +++ L+N
Sbjct: 457 DKRVASITKFQL--LLVTAFKKFSHITHSLIEDERKKHYEGVMNSIESFAKRTQIRSLQN 514
Query: 580 DYSLLNREHIT 590
Y L R ++
Sbjct: 515 -YGTLTRTDLS 524
>Hs21361485 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 533
Score = 89.7 bits (221), Expect = 1e-17
Identities = 64/229 (27%), Positives = 106/229 (45%), Gaps = 15/229 (6%)
Query: 268 WSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSP 327
W + N+ + +K++ KGIP+ +R WQ L++S +P
Sbjct: 60 WLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAP 119
Query: 328 HEK----AIKRDLSRTKFIPE--------GKTDSLFSVLKAYSLYDPPVGYTQGMGFIAT 375
+ I++DL R E G+ D L+ +LKAY++Y P GY Q +A
Sbjct: 120 GDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQD-LYRILKAYTIYRPDEGYCQAQAPVAA 178
Query: 376 TLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIR 435
L+++ E QAF L ++ Y L + G+ + L F LL P + HL R
Sbjct: 179 VLLMHMPAE-QAFWCLVQICDKY-LPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRR 236
Query: 436 QGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLM 484
Q I ++ T+WF+ +FA P VLR+ D+ EG++ + + +L L+
Sbjct: 237 QRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLL 285
>At3g07890 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 389
Score = 87.4 bits (215), Expect = 7e-17
Identities = 61/221 (27%), Positives = 100/221 (44%), Gaps = 14/221 (6%)
Query: 286 LETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXX-------SPHEKAIKRDLSR 338
L+ + KGIP +R +W L+ + K +P + I DL R
Sbjct: 98 LKRLIRKGIPPVLRPKVWFSLSGAAKKKSTVPESYYSDLTKAVEGMVTPATRQIDHDLPR 157
Query: 339 T------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLT 392
T PEG +L VL YS D VGY QG+ ++A L+L + E AF +L
Sbjct: 158 TFPGHPWLDTPEGHA-ALRRVLVGYSFRDSDVGYCQGLNYVAALLLLVMKTEEDAFWMLA 216
Query: 393 KLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMF 452
L++ +RD + + G ++ F LL + ++ HL G ++ AT+WFL +F
Sbjct: 217 VLLENVLVRDCYTTNLSGCHVEQRVFKDLLAQKCSRIATHLEDMGFDVSLVATEWFLCLF 276
Query: 453 AYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLII 493
+ P E LR+ D++ EG + + +L + L++
Sbjct: 277 SKSLPSETTLRVWDVLFYEGAKVLFHAALAIFKMKENELLM 317
>CE28759 [TR] KOG2223 Uncharacterized conserved protein contains TBC domain
Length = 614
Score = 86.7 bits (213), Expect = 1e-16
Identities = 75/308 (24%), Positives = 127/308 (40%), Gaps = 39/308 (12%)
Query: 221 IQNETELELRDDKEREHAKEGTKTLREEYDSLLDHADKELVQYDWPFWSKLVHNFSDIVK 280
++ + E R +KER AK K L E+ + H + V+ P W ++
Sbjct: 239 LEQAKKKEQRAEKERLQAKAEQKRLEEQTAA---HC-RVWVEQILPKWEEM--------- 285
Query: 281 DDSKKLETEVGKGIPTQVRGIIW----------------QLLTSSNYKXXXXXXXXXXXX 324
DSK+ +G+P +VRG +W L+ + K
Sbjct: 286 KDSKRCRELWWQGVPAKVRGELWFLTIGNQIEITKELYDGLMDQAEEKIAKQLAEQNKNS 345
Query: 325 XSPHEKAIKR---DLSRT-----KFIPEGK-TDSLFSVLKAYSLYDPPVGYTQGMGFIAT 375
E ++ + D +RT F +G D L +L AY++ P +GY Q M FIA
Sbjct: 346 AERKETSVTQIHLDATRTFTSLGMFQKDGPYYDHLLKLLSAYAILRPDIGYVQSMTFIAA 405
Query: 376 TLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIR 435
L++ + + AF L+ F P + +D LE+ P L+ HL +
Sbjct: 406 VLLIQM-DPYPAFISFANLLDRSLQSAFFGLKQPQMTEYFIAYDRYLEQELPALHQHLDK 464
Query: 436 QGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILS 495
+R ++ +W M+A PL+ RI D+ +G E + K +L ++ L+ +
Sbjct: 465 LDVRPDLYLIEWTFAMYAKSLPLDVTCRIWDVYFRDGEEFLFKAALGILRMYEPKLLTMD 524
Query: 496 FDSLLDFL 503
FD ++FL
Sbjct: 525 FDDCVEFL 532
>Hs17485595 [R] KOG4347 GTPase-activating protein VRP
Length = 796
Score = 86.3 bits (212), Expect = 1e-16
Identities = 81/325 (24%), Positives = 144/325 (43%), Gaps = 41/325 (12%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQLL--------TSSNYKXXXXXXXXXXXXXSPHEKAIKR 334
+KK V +GIP +RG +W L T+ +Y + E I+R
Sbjct: 477 TKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEE--IER 534
Query: 335 DLSRT-----KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFS 389
DL R+ F + +L VL AY+ +P +GY Q M + + L+L +EE +AF
Sbjct: 535 DLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEE-EAFW 593
Query: 390 LLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFL 449
LL + + L D F + G ++ F+ L+ ++ PQL H+ S++ + WFL
Sbjct: 594 LLVAVCERM-LPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSV-SLSWFL 651
Query: 450 TMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQ 509
T+F P+E + ++D +GI+++L+ L ++ N L+ D+ F
Sbjct: 652 TLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFD 711
Query: 510 HYASKENPEEYDIDR--FISDS----LEIKLTPLQLERYVK----EYDEIHKL------- 552
+ +K++P ++ + +SD + +T L E K Y++IH +
Sbjct: 712 NVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGNIRYEDIHSMRCRNRLY 771
Query: 553 ------ETEKEQQYEEQRIKNRQLQ 571
ET K+ Q ++ QL+
Sbjct: 772 VIQTLEETTKQNVVSMQPMRKNQLE 796
>SPBC1778.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 414
Score = 83.6 bits (205), Expect = 1e-15
Identities = 77/233 (33%), Positives = 108/233 (46%), Gaps = 24/233 (10%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQ--LLTSSNYKXXXXXXXXXXXXXSPHEKAIKRDLSRT- 339
++KL KGIP R I W L+ S K ++ I D+ RT
Sbjct: 148 TRKLILRTFKGIPDCWRSIAWWSFLVDSLPDKKLIDKYYQLNEQICDYDVQIDLDVPRTA 207
Query: 340 --------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLL 391
++I G LF VL A +LY P VGY QGM IA TL++ EE QAF ++
Sbjct: 208 ATHFLFRKRYI--GGQRLLFRVLHAVALYIPRVGYVQGMASIAATLLIYYPEE-QAFIMM 264
Query: 392 TKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEE-NDPQLYNHLIRQGIRSTMFATQWFLT 450
L++ G+ DLF G L L FD L E + Q HL G + FAT+W+LT
Sbjct: 265 VNLLENRGMGDLFSSGFDTL---LKAFDMLKHELSFTQSGRHLAEIGAEPSAFATRWYLT 321
Query: 451 MFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILS--FDSLLD 501
+F P LRI D++ L G T+ L + +L ++ +D+L+D
Sbjct: 322 VFHQCVPFHTQLRIWDLLFLLGGSK----GQTVRLLQATSLAVIQGMWDTLID 370
>SPCC1259.11c [R] KOG4347 GTPase-activating protein VRP
Length = 720
Score = 82.8 bits (203), Expect = 2e-15
Identities = 64/250 (25%), Positives = 116/250 (45%), Gaps = 20/250 (8%)
Query: 274 NFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXS------P 327
NF+ I + +KL V GIP +R IW+ + S + S
Sbjct: 200 NFNLIQTPNFQKL---VQSGIPNNLRADIWETCSGSLFPRWKSKGFYAKNIDSVINNRCE 256
Query: 328 HEKAIKRDLSRTKFIPEGKT-------DSLFSVLKAYSLYDPPVGYTQGMGFIATTLILN 380
+ + I++DL+R+ +P+ ++L +L YS + VGY Q M + L++
Sbjct: 257 YSEEIEKDLTRS--LPDYPAYQSPTGINTLRRILLFYSETNKEVGYCQAMNIVLAALLVY 314
Query: 381 CEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRS 440
C EE QA+ L ++L + Y + + + GL+L L F+ +LE P LY +I +
Sbjct: 315 CTEE-QAYFLFSQLCEFY-IPGYYAKIIHGLLLDLTVFEYVLEHTLPHLYQKIIELDMDL 372
Query: 441 TMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLL 500
+ WF ++F F L++ RI+D + + G + + +L L N++ ++ + DS +
Sbjct: 373 KLITINWFFSLFIKDFRLDYAFRILDCLFVNGPRVLFQVALALFKVNAQGILNATDDSSV 432
Query: 501 DFLKEDLFQH 510
+ F H
Sbjct: 433 MKVFRQCFDH 442
>7300111 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 299
Score = 82.8 bits (203), Expect = 2e-15
Identities = 61/235 (25%), Positives = 116/235 (48%), Gaps = 14/235 (5%)
Query: 268 WSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLT-SSNYKXXXXXXXXXXXXXS 326
W ++ +D+ + D+K L+ + KGIP R +W ++ ++ +
Sbjct: 15 WEAILQQNTDLTQVDAK-LKRYIRKGIPGPYRPDVWMKISGAAAAQRRSPDLFRNLLRTE 73
Query: 327 PHEK----AIKRDLSRTKFIPEG-----KTDSLFSVLKAYSLYDPPVGYTQGMGFIATTL 377
P +K +I DL RT P+ K L+++L AY+ ++ VGY QG+ +IA L
Sbjct: 74 PFDKEISDSISIDLPRT--FPDNIHFDMKKQRLYNILIAYAHHNRDVGYCQGLNYIAGLL 131
Query: 378 ILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQG 437
++ ++E ++F LL +++ + M L+ L F L+ P + H+ G
Sbjct: 132 LIVTDDEEKSFWLLKHIVENI-VPQYHSHNMANLLRDLAVFRELVIRRIPAVNRHVDNLG 190
Query: 438 IRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLI 492
+ + A++WF+ +FA P+E VLRI D V EG + + + +LT+ + + ++
Sbjct: 191 LPYPVIASKWFICIFAEVLPVETVLRIWDCVFAEGYKIVFRAALTMFVTHKNAIL 245
>Hs22043863 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 104
Score = 82.4 bits (202), Expect = 2e-15
Identities = 41/97 (42%), Positives = 60/97 (61%)
Query: 384 EWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMF 443
E QAF +L K+M YGLRDL+ L K YQ + L++E P L++H + + M+
Sbjct: 3 EEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMY 62
Query: 444 ATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFS 480
A+QWFLT+F KFPL V I+D+++ E S L+F+
Sbjct: 63 ASQWFLTLFTAKFPLCMVFHIIDLLLCESGISALQFT 99
>Hs14733591 [TR] KOG2223 Uncharacterized conserved protein contains TBC domain
Length = 693
Score = 82.4 bits (202), Expect = 2e-15
Identities = 71/257 (27%), Positives = 109/257 (41%), Gaps = 41/257 (15%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQL--------------------------LTSSNYKXXXX 316
S+K+ +GIP VRG +W L L++ +
Sbjct: 391 SRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERWRSLSTGGSEVENE 450
Query: 317 XXXXXXXXXSPHEKAIKRDLSRTK----FIPEGKT--DSLFSVLKAYSLYDPPVGYTQGM 370
+ IK D+SRT +G D L S+L AY+ Y P VGY QGM
Sbjct: 451 DAGFSAADREASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM 510
Query: 371 GFIATTLILNCE--EEWQAFS-LLTKLMKVYGLRDLFLPGMPGLMLKLYQ-FDTLLEEND 426
FIA LILN + + + AFS LL K ++ F GLML + F+ EEN
Sbjct: 511 SFIAAVLILNLDTADAFIAFSNLLNKPCQM-----AFFRVDHGLMLTYFAAFEVFFEENL 565
Query: 427 PQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLK 486
P+L+ H + + ++ W T+++ PL+ RI D+ +G E + + +L ++
Sbjct: 566 PKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKL 625
Query: 487 NSRNLIILSFDSLLDFL 503
L + F + FL
Sbjct: 626 FEDILTKMDFIHMAQFL 642
>Hs22042713 [R] KOG4347 GTPase-activating protein VRP
Length = 1266
Score = 81.6 bits (200), Expect = 4e-15
Identities = 88/340 (25%), Positives = 151/340 (43%), Gaps = 36/340 (10%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQLLTSS-NYKXXXXXXXXXXXXXSPHE-----KAIKRDL 336
++K V KGIP +RG +W LL+ + N K S + + I+RDL
Sbjct: 505 TEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDL 564
Query: 337 SRT-----KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLL 391
R+ F E +L VL AY+ +P +GY Q M + + L+L +EE +AF LL
Sbjct: 565 HRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEE-EAFWLL 623
Query: 392 TKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTM 451
L + L D + + G ++ F+ L + PQLY+ + G+ ST+ + WFLT+
Sbjct: 624 VALCERM-LPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTI-SLSWFLTL 681
Query: 452 FAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQHY 511
F P E + ++D EGI+ + + +L ++ N L+ D +
Sbjct: 682 FLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYLDSV 741
Query: 512 ASKEN--PEEYDIDRFISDSLEIKLTPLQLERYVK-EYDEIHKLETEK-EQQYEEQRIKN 567
+K++ P + +SD +E + + R ++ Y++ + + EQ +QR+K
Sbjct: 742 TNKDSTLPPIPHLHSLLSDDVE-PYPEVDIFRLIRTSYEKFGTIRADLIEQMRFKQRLKV 800
Query: 568 RQLQKELKK-----------------LENDYSLLNREHIT 590
Q ++ K LE Y+L EH+T
Sbjct: 801 IQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLT 840
>SPCC1620.12c [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 595
Score = 81.3 bits (199), Expect = 5e-15
Identities = 92/496 (18%), Positives = 183/496 (36%), Gaps = 53/496 (10%)
Query: 223 NETELELRDDKEREHAKEGTKTLREEYDSLL----DHADKELV---QYDWPFWSKLVHNF 275
N+TE E D + H + S++ +KE + DW W+ +
Sbjct: 78 NQTEFEQLRDSYKSHGDLNSAINDSRIQSIIFELNQQCEKESIPVSNIDWLQWASVPLFA 137
Query: 276 SDIVKDDSKKLETEVGKG---------------IPTQVRGIIWQLLTSSNYKXXXXXXXX 320
D+ D S T IP+ R ++WQ L S+
Sbjct: 138 YDLPPDPSNPNATSSSPPPLTPILELIKQNNFCIPSPCRKLVWQSLVSAERNELLTLYAT 197
Query: 321 XXXXXSPHEKAIKRDLSRTKFIP-------------EGKTDSLFSVLKAYSLYDPPVGYT 367
+ + +I++ + F + T+S+F VL A++L+D V Y
Sbjct: 198 LSTTNNSLDSSIRKIIRMQSFRGPLEPFKYSSTTRHKVSTESIFHVLHAFTLFDTTVEYN 257
Query: 368 QGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFD-TLLEEND 426
T L+ + AF L ++ G+R+ F+ L L+ L +
Sbjct: 258 IEPLLWLTCAFLSYMAQGNAFRSLVCFIQRGGIREFFISQSSSLDESLFALVWGCLGDLA 317
Query: 427 PQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLK 486
P + L R + S FA L LR+MD++ + G+E ++ + + LK
Sbjct: 318 PSVAISLQRIKVSSLCILYPSLACCFADSLQLPEALRLMDLIAIYGLEMFVRLLVAIFLK 377
Query: 487 NSRNLI-ILSFDSLLDFLKEDLFQHYASK-------ENPEEYDIDRFISDSLEIKLTPLQ 538
+ ++ ++S + + +L+ D+ Y D++ ++ DSL + + Q
Sbjct: 378 DRDKIVNMVSHEQWVKYLRSDVLASYRQPLVQKYTFYTRTPVDLNAWVEDSLALNIDTTQ 437
Query: 539 LERYVKEYDEIHKLETEKEQQYEEQRIKNRQLQKELKKLENDYSLLNREHITIANELIEN 598
Y+ ++ T ++ EE + +N L ++ LE +LN+E+ ++ L +
Sbjct: 438 FPSYLSYHETSVSHNTYRQNNLEELKNQNDYLTSQITNLEEGMVMLNKENTKLSEALSNH 497
Query: 599 RLRMETLQXXXXXXXXXXXXXXXXXXRELYKQTLPNPDAEIPTDLKADLNRTMERNLEVM 658
R+ ++ K L E+ L +++ +RN + +
Sbjct: 498 RVTRSEMEEATEILKNNSAD---------LKAQLEKQPQELENRLLQEISILKQRNQKFL 548
Query: 659 DENQELRTRLDELEKE 674
N ++ L++E
Sbjct: 549 KNNATSIQQIQYLDEE 564
>ECU11g1700 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 320
Score = 80.9 bits (198), Expect = 6e-15
Identities = 62/248 (25%), Positives = 117/248 (47%), Gaps = 23/248 (9%)
Query: 292 KGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEKAIKRDLSRT--------KFIP 343
+GIP ++ +W L T + S +E I D+ RT +
Sbjct: 74 QGIPLSLKYRLWGLFTQ---RTSDFDYSALISRKSGYEHQIHVDVQRTFRRHFLFSREYG 130
Query: 344 EGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDL 403
G+ + LF++L AYS Y+P VGY QGM A L++ EE +AF +L +++ L L
Sbjct: 131 RGQCE-LFNILTAYSNYNPEVGYCQGMSSAAALLLMYFPEE-EAFEMLVSIIRNNHLEAL 188
Query: 404 FLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLR 463
F + + D + + P++Y+HL+ Q I ++A W+LT+F +F ++ VLR
Sbjct: 189 FDKKLSKVPRVQKIQDEIFKALIPEVYSHLLHQNIDIGVYAVGWYLTLFT-RFDIKLVLR 247
Query: 464 IMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQHYASKENPEEYDID 523
+ D + + F+ ++ + ++ L + L++F+ + ++ D++
Sbjct: 248 MWDFFLFFDFSIFMFFAAGILKFFAMGILELQGEQLIEFI---------GTLDSKDVDVE 298
Query: 524 RFISDSLE 531
R +S +E
Sbjct: 299 RIVSYVVE 306
>CE17203 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 458
Score = 79.0 bits (193), Expect = 2e-14
Identities = 59/239 (24%), Positives = 102/239 (41%), Gaps = 30/239 (12%)
Query: 268 WSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXX----- 322
W +++ N+ + + + ++ KGIP +RG W+ L+ + Y+
Sbjct: 162 WIQMLDNWRYFMDEKFELVKNRCRKGIPPSLRGRAWKYLSGATYQMEVSSNRFVFDYCVK 221
Query: 323 -XXXSPHEKAIKRDLSRT-----------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGM 370
I++DLSR K+ GK D LF +LKA+++ P GY QG
Sbjct: 222 QAGDPKWNDDIQKDLSRQFPEHEMFARVGKYGNNGKND-LFDLLKAWTILHPEEGYCQGQ 280
Query: 371 GFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFD-----TLLEEN 425
IA L+++ AF ++ Y LPG L+ Q D L+++
Sbjct: 281 APIAAVLLMHMPVR-DAFYCFVQICHKY------LPGYYSSGLEAVQTDGDILTKLIKDR 333
Query: 426 DPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLM 484
Y H G+ ++ +WF+ F P VLR+ D+ + EG++ + K +L L+
Sbjct: 334 SKLTYRHFKANGVDPALYMIEWFMCCFCRTLPWPTVLRVWDMFLCEGVKILFKVALVLL 392
>CE08508 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 1244
Score = 78.6 bits (192), Expect = 3e-14
Identities = 59/222 (26%), Positives = 92/222 (40%), Gaps = 22/222 (9%)
Query: 292 KGIPTQVRGIIWQLLTSSNYKXXXXXXXXXX--------------XXXSPHEKAIKRDLS 337
KGIP +R +W++L + + H+K I DL
Sbjct: 374 KGIPNSLRATVWKILINQQVEDLKNVYGKYYYRNLCNIQGGEDEKTYSDVHQKQINLDLL 433
Query: 338 RTK-----FIPEGK--TDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSL 390
RT F+ L VL A+ L++ +GY QGM F+A T +L E AF
Sbjct: 434 RTMPNNVHFMSANSKGVTQLLQVLHAFCLHNSQIGYCQGMNFLAATALLFVGPE-DAFWF 492
Query: 391 LTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLT 450
L + + Y + F + G LLE P++ HL I F WF++
Sbjct: 493 LIAVTERYFDKTYFDSNLTGAQADQEVLKGLLEVQHPKIMKHLKSLDIDVASFTLNWFIS 552
Query: 451 MFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLI 492
+F P +LRI D +LEG + + +F++ L+ K+ +I
Sbjct: 553 LFFDAVPFNTLLRIWDCFLLEGPKVLFRFAIVLIGKHEEEII 594
>Hs14745035 [TR] KOG2223 Uncharacterized conserved protein contains TBC domain
Length = 775
Score = 78.2 bits (191), Expect = 4e-14
Identities = 56/179 (31%), Positives = 83/179 (46%), Gaps = 9/179 (5%)
Query: 332 IKRDLSRT----KFIPEGKT--DSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEW 385
IK D+SRT +G D L S+L AY+ Y P VGY QGM FIA LILN EE
Sbjct: 547 IKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEAD 606
Query: 386 QAFSLLTKLMKVYGLRDLFLPGMPGLMLKLY-QFDTLLEENDPQLYNHLIRQGIRSTMFA 444
+ L K L F +MLK + F+ EEN +L+ H + ++
Sbjct: 607 AFIAFANLLNKPCQL--AFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYL 664
Query: 445 TQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFL 503
W T+++ PL+ R+ D+ +G E + + L ++ L+ + F + FL
Sbjct: 665 IDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFL 723
>Hs13376023 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 257
Score = 77.8 bits (190), Expect = 5e-14
Identities = 60/175 (34%), Positives = 91/175 (51%), Gaps = 14/175 (8%)
Query: 329 EKAIKRDLSRTKFIPEG-----KTD-----SLFSVLKAYSLYDPPVGYTQGMGFIATTLI 378
E AI+ DL+RT P+ TD +L++VL AY ++ VGY QGM FIA L+
Sbjct: 21 EDAIRTDLNRT--FPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLV 78
Query: 379 LNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGI 438
L E ++F LL L+ L D + P M GL L+ P + + R G+
Sbjct: 79 LITNNEEESFWLLDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGV 137
Query: 439 RSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLII 493
T+ ++WF+ +F P+E VLRI D + EG + + + +LTL +K + LI+
Sbjct: 138 LWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTL-IKQHQELIL 191
>7296423 [R] KOG4347 GTPase-activating protein VRP
Length = 1291
Score = 77.8 bits (190), Expect = 5e-14
Identities = 74/265 (27%), Positives = 125/265 (46%), Gaps = 26/265 (9%)
Query: 332 IKRDLSRTKFIPEG----KTD---SLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEE 384
I RDL R+ +PE TD +L VL+AY+L +P VGY Q M +++ +L C+EE
Sbjct: 508 IDRDLPRS--LPEHPAFQSTDGIGALRRVLQAYALRNPQVGYCQAMNIVSSVFLLFCDEE 565
Query: 385 WQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFA 444
AF +L L + L D + + G + + L+E + P L+ HL + G+ M +
Sbjct: 566 -NAFWMLASLCENL-LPDYYKDKVVGAQIDQGVLNELVETHLPDLHGHLEQLGV-IKMIS 622
Query: 445 TQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDS-----L 499
WFLT+F E L I+D EG + + SL ++ N L+I D L
Sbjct: 623 ISWFLTIFMSVISYESSLHILDCFFYEGAKIIFMISLQIIEWNRDKLLICQDDGEAMLVL 682
Query: 500 LDFLKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLETEKEQQ 559
++L+ Y ++ ++R + + L E Y K ++I +Q+
Sbjct: 683 QNYLEGVYNPEYQVPPTTDKRKMERKVQTQ---TVQTLIHEAYTKFGEDI------TQQR 733
Query: 560 YEEQRIKNRQLQKELKKLENDYSLL 584
EE R K+R+L ++N+ +++
Sbjct: 734 IEELRNKHRRLTMRQFDIDNEKTIV 758
>CE19171 [R] KOG4347 GTPase-activating protein VRP
Length = 1270
Score = 75.9 bits (185), Expect = 2e-13
Identities = 76/289 (26%), Positives = 129/289 (44%), Gaps = 34/289 (11%)
Query: 234 EREHAKEGTKTLREEYDSLLDHADKELVQYDWPF-----------WSKLVHNF-SDIVKD 281
+ E + T + +D L+ D L++ +PF W+K + + + +
Sbjct: 444 DSERGRSSTSSSSSSFDKLI--WDCPLIE-KYPFGADASDKCREKWNKYLQEYGTGVCMY 500
Query: 282 DSKKLETEVGKGIPTQVRGIIWQLLTSS------NYKXXXXXXXXXXXXXSPHEKAIKRD 335
+ +L + +G+P Q+RG IW + + + N S + I+RD
Sbjct: 501 RTVELHRLLLEGVPLQLRGQIWMVCSGAAAEMALNPGYYRELLHKNQGVYSVALEEIERD 560
Query: 336 LSRTKFIPEGKT-------DSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAF 388
L R+ +PE D+L +L AY+ +P +GY Q M + + L+L +EE +AF
Sbjct: 561 LHRS--LPEHPAFQQGPGIDALRRILTAYAFRNPNIGYCQAMNIVGSVLLLFTKEE-EAF 617
Query: 389 SLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWF 448
LL + + L D + + G ++ F L+E P + L R G+ M A WF
Sbjct: 618 WLLVAVCERL-LPDYYNTKVVGALVDQGVFSELVERLLPTVGAQLTRLGL-DDMVALSWF 675
Query: 449 LTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFD 497
LT+F + +RI+D+ EG M + +L MLK + LI S D
Sbjct: 676 LTVFLSAIKFDAAVRILDLFFFEGARLMFQVALE-MLKENEKLICESRD 723
>CE18397 [R] KOG4347 GTPase-activating protein VRP
Length = 1268
Score = 75.9 bits (185), Expect = 2e-13
Identities = 76/289 (26%), Positives = 129/289 (44%), Gaps = 34/289 (11%)
Query: 234 EREHAKEGTKTLREEYDSLLDHADKELVQYDWPF-----------WSKLVHNF-SDIVKD 281
+ E + T + +D L+ D L++ +PF W+K + + + +
Sbjct: 444 DSERGRSSTSSSSSSFDKLI--WDCPLIE-KYPFGADASDKCREKWNKYLQEYGTGVCMY 500
Query: 282 DSKKLETEVGKGIPTQVRGIIWQLLTSS------NYKXXXXXXXXXXXXXSPHEKAIKRD 335
+ +L + +G+P Q+RG IW + + + N S + I+RD
Sbjct: 501 RTVELHRLLLEGVPLQLRGQIWMVCSGAAAEMALNPGYYRELLHKNQGVYSVALEEIERD 560
Query: 336 LSRTKFIPEGKT-------DSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAF 388
L R+ +PE D+L +L AY+ +P +GY Q M + + L+L +EE +AF
Sbjct: 561 LHRS--LPEHPAFQQGPGIDALRRILTAYAFRNPNIGYCQAMNIVGSVLLLFTKEE-EAF 617
Query: 389 SLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWF 448
LL + + L D + + G ++ F L+E P + L R G+ M A WF
Sbjct: 618 WLLVAVCERL-LPDYYNTKVVGALVDQGVFSELVERLLPTVGAQLTRLGL-DDMVALSWF 675
Query: 449 LTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFD 497
LT+F + +RI+D+ EG M + +L MLK + LI S D
Sbjct: 676 LTVFLSAIKFDAAVRILDLFFFEGARLMFQVALE-MLKENEKLICESRD 723
>Hs5902154 [R] KOG4347 GTPase-activating protein VRP
Length = 897
Score = 74.7 bits (182), Expect = 4e-13
Identities = 82/339 (24%), Positives = 149/339 (43%), Gaps = 36/339 (10%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEKA------IKRDL 336
++K+ V GIP +RG +W L + + K I+RDL
Sbjct: 252 TEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDL 311
Query: 337 SRT-----KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLL 391
R+ F E +L VL AY+ +P +GY Q M + + L+L +EE +AF LL
Sbjct: 312 HRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEE-EAFWLL 370
Query: 392 TKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTM 451
+ + L D F + G + F+ L++ + P+L H+ +++ + WFLT+
Sbjct: 371 VAVCERM-LPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASV-SLSWFLTL 428
Query: 452 FAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNL--------IILSFDSLLDFL 503
F PLE + ++D +GI+++ + L ++ N+ +L ++ LD +
Sbjct: 429 FLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILSRFLDHI 488
Query: 504 KED------LFQHYASKENPEE----YDIDRFISDSLEIKLTPLQLER--YVKEYDEIHK 551
K + + H+A + +E DI I DS E K +E+ +++ I
Sbjct: 489 KNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIRDSYE-KFGDQSVEQIEHLRYKHRIRV 547
Query: 552 LETEKEQQYEE-QRIKNRQLQKELKKLENDYSLLNREHI 589
L+ ++ + R+ ++ + LE Y L REH+
Sbjct: 548 LQGHEDTTKQNVLRVVIPEVSILPEDLEELYDLFKREHM 586
>Hs8922167 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 468
Score = 73.9 bits (180), Expect = 8e-13
Identities = 74/311 (23%), Positives = 126/311 (39%), Gaps = 29/311 (9%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXX------XXXXXXXXXSPHEKAIKRDL 336
S +L+ + G+P + R +W+ L + P + I+ DL
Sbjct: 155 SAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDL 214
Query: 337 SRTKFIPEGK---------TDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQA 387
+RT P K D L VL A+S +P +GY QG+ +A +L EEE A
Sbjct: 215 NRT--FPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESA 272
Query: 388 FSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQW 447
F L +++ D + + + LL E P+L HL + + ++ W
Sbjct: 273 FWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNW 332
Query: 448 FLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILS-----FDSLLDF 502
FL +FA +LR+ D + EG + + +++L + N + ++ L + L F
Sbjct: 333 FLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFF 392
Query: 503 LKEDLFQHYASKENPEEYDIDRFISDSLEIKLTPLQLERYVKEYDEIHKLETEKEQQYEE 562
K + N D++ F L +L + ER E E+ +L+ E Y E
Sbjct: 393 TK--TISNSRKLMNIAFNDMNPFRMKQLR-QLRMVHRERLEAELRELEQLKAE----YLE 445
Query: 563 QRIKNRQLQKE 573
+R R+ E
Sbjct: 446 RRASRRRAVSE 456
>Hs22056446 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 788
Score = 72.0 bits (175), Expect = 3e-12
Identities = 59/238 (24%), Positives = 103/238 (42%), Gaps = 22/238 (9%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXX---------XXXXXXSPHEKAIK 333
S +L+ + GIP + R +W+ + + +P K I+
Sbjct: 526 SPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIE 585
Query: 334 RDLSRTKFIPEGKTDS---------LFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEE 384
DL RT +P K S L +VL A+S +P +GY QG+ + +L E+E
Sbjct: 586 LDLLRT--LPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQE 643
Query: 385 WQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFA 444
AF L +++V+ RD + + G + F L+ E P+L+ H + + T+
Sbjct: 644 -DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLIT 702
Query: 445 TQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDF 502
WFL +F + + +I D + EG + + +F+L L ++ L DS+ F
Sbjct: 703 FNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQ-DSMSIF 759
>At3g55020 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 814
Score = 72.0 bits (175), Expect = 3e-12
Identities = 50/161 (31%), Positives = 80/161 (49%), Gaps = 13/161 (8%)
Query: 332 IKRDLSRT----KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEE--- 384
I++DL RT + + ++L +L AY+ ++P VGY Q M F A L+L EE
Sbjct: 310 IEKDLPRTFPGHPALDDDGRNALRRLLTAYARHNPSVGYCQAMNFFAALLLLLMPEENAF 369
Query: 385 WQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFA 444
W L+ Y ++ + L+L + L+ E P+L +HL G++
Sbjct: 370 WALIGLIDDYFNGYYSEEMIESQVDQLVL-----EELVRERFPKLVHHLDYLGVQVAWVT 424
Query: 445 TQWFLTMFAYKFPLEFVLRIMDIVILEGIESML-KFSLTLM 484
WFL++F P E VLR+ D+++ EG ML + +L LM
Sbjct: 425 GPWFLSIFMNMLPWESVLRVWDVLLFEGTRVMLFRTALALM 465
>SPAC4G8.04 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 772
Score = 70.1 bits (170), Expect = 1e-11
Identities = 94/448 (20%), Positives = 168/448 (36%), Gaps = 58/448 (12%)
Query: 112 VNNETEP-IDTDKDSLSNESVIKSKQEILEQKIESFNNETKPPHLPPRDHIAGEKPPLPS 170
V+ +EP ++T S N S K+ + L + + + N KP L + P +PS
Sbjct: 293 VSATSEPEVETYSVSTKNSSSNKNLRSSLSKLLSTSNLNNKPLSL------SSTAPSMPS 346
Query: 171 RSHVATSLSGPVHFVPPPLSEEMK------SPKFRAHFNQHKRSDSSDFDLILNRFIQN- 223
V P PP + + K S + F ++ S D L N
Sbjct: 347 IGSVELGNMIPKETQPPSMRNDWKDYLDNNSKEILDQFGFLQKRPSHDTPLCPEDIKLNQ 406
Query: 224 -------ETELELRDD---KEREHAKEGTKTLREEYDSLLDHADKELVQYDWPFWSKLVH 273
E+ L DD E + + L ++ D LLD + Q +W + + ++
Sbjct: 407 KQTLSFYESNYGLVDDFFGNELDGLNDSPLLLNKK-DILLDMKESTR-QKNWSLFFQRLY 464
Query: 274 NFSDIVKDDS--------------------KKLETEVGKGIPTQVRGIIW-------QLL 306
I +D+ K V G+P + +W QL
Sbjct: 465 KKYKITDEDTIGLLGISSIGVKGRHGKKRWHKFRELVKNGVPLCYKAKVWLECSGAYQLH 524
Query: 307 TSSNYKXXXXXXXXXXXXXSPH-EKAIKRDLSRTKFIPEGK---TDSLFSVLKAYSLYDP 362
+ Y+ + I R +++ F GK L +L AYS ++P
Sbjct: 525 SPGYYEELLSRTDEVESASVAQIDMDINRTMAKNVFFG-GKGPGIPKLRRILVAYSRHNP 583
Query: 363 PVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLL 422
+GY QGM I L+L E AF +L +++ F P + + +
Sbjct: 584 HIGYCQGMNVIGAFLLLLYASEEDAFYMLMSIIENVLPPKYFTPDLMTSRADQLVLKSFV 643
Query: 423 EENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLT 482
+E+ P++Y+HL G+ + WFL+++ P RI D++ +G + + +LT
Sbjct: 644 KESLPEIYSHLELLGVDLDAISFHWFLSVYTDTLPTNISFRIFDMLFCDGYVCLFRVALT 703
Query: 483 LMLKNSRNLIILSFDSLLDFLKEDLFQH 510
++ + ++ + S + DL Q+
Sbjct: 704 ILKSLKQQILACNSSSAIYSFLSDLVQY 731
>CE29155 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 908
Score = 69.3 bits (168), Expect = 2e-11
Identities = 54/222 (24%), Positives = 94/222 (42%), Gaps = 22/222 (9%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQLLTS-----------SNYKXXXXXXXXXXXXXSPHEKA 331
S L+T + G+P RG +W+++ + + Y ++ A
Sbjct: 620 SPDLKTLIRTGVPPAYRGRVWKIIVTHWVKDKQAELGNGYYQSMLRKAGTKKQDGSYDAA 679
Query: 332 IKR-DLSRTKFIPEGKT---------DSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNC 381
IK+ DL + +P K + L +VL A+ ++ VGY QG+ +A +LN
Sbjct: 680 IKQIDLDLARTLPTNKLFDEPDSANIEKLRNVLYAFRYHNSHVGYCQGLNRLAAIALLNL 739
Query: 382 EEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRST 441
+E+ +F L ++ + + G + L+ E P+L HL + +
Sbjct: 740 DEQ-DSFWFLVACVEHLQPEGYYTSSLIGAVADQKVLRDLVAEKLPKLAAHLRALEVDLS 798
Query: 442 MFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTL 483
+FA WFLT F P L I D + EG + + +F+L L
Sbjct: 799 LFALSWFLTCFVDVLPHSIYLTIFDAFLYEGNKVLFRFALAL 840
>Hs14916463 [R] KOG1093 Predicted protein kinase (contains TBC and RHOD
domains)
Length = 822
Score = 67.0 bits (162), Expect = 9e-11
Identities = 62/247 (25%), Positives = 105/247 (42%), Gaps = 21/247 (8%)
Query: 294 IPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEKAIKRDLSRTKFI------PEGKT 347
IP +RG+ W L P ++ I+ D+ R PEG
Sbjct: 396 IPPLMRGLTWAALLGVEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHA 455
Query: 348 DSLFSVLKAYSLYDPPVGYTQGMGFI-ATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLP 406
VLKA+ + P + Y QG+ + A L LN E A++ ++ + Y L + FL
Sbjct: 456 -KFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAFIPKY-LYNFFLK 513
Query: 407 GMPGLMLK-LYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIM 465
++ + L F ++ +DP+L NHL G ++A WFLTMF + FPL + +
Sbjct: 514 DNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLW 573
Query: 466 DIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQHYASKENPEEYDIDRF 525
D ++L + ++ + L+ F+ + L DL E DI+R
Sbjct: 574 DTLLLGNSSFPFCIGVAILQQLRDRLLANGFNECI-LLFSDL----------PEIDIERC 622
Query: 526 ISDSLEI 532
+ +S+ +
Sbjct: 623 VRESINL 629
>Hs11034851 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 777
Score = 65.9 bits (159), Expect = 2e-10
Identities = 77/309 (24%), Positives = 125/309 (39%), Gaps = 39/309 (12%)
Query: 216 ILNRFIQNETELELRDDKEREHAKEGTKTLREEYDS----------LLDHADKELVQYDW 265
IL ++ Q E E + E + + G + +EE D L++ A + L W
Sbjct: 24 ILAKYTQKE---ESAEQPEFYYDEFGFRVYKEEGDEPGSSLLANSPLMEDAPQRL---RW 77
Query: 266 PFWSKLVHNFS--DIVKDD-------SKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXX 316
+ HN D+ D S+KL + V GIP +R +W L+ + K
Sbjct: 78 QAHLEFTHNHDVGDLTWDKIAVSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNS 137
Query: 317 XXXXXXXXXSPHE------KAIKRDLSRTK-----FIPEGK--TDSLFSVLKAYSLYDPP 363
+ K I++DL RT F G L VL+A + P
Sbjct: 138 ELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPE 197
Query: 364 VGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLE 423
+GY QG G +A L+L EEE AF +++ +++ F + G+ L+
Sbjct: 198 IGYCQGTGMVAACLLLFLEEE-DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIV 256
Query: 424 ENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTL 483
+ P+L L I ++ WFLT FA ++ +LRI D+ EG + + +L +
Sbjct: 257 QYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGM 316
Query: 484 MLKNSRNLI 492
+ LI
Sbjct: 317 LHLKEEELI 325
>SPAC6F6.08c [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 299
Score = 63.5 bits (153), Expect = 1e-09
Identities = 52/196 (26%), Positives = 87/196 (43%), Gaps = 15/196 (7%)
Query: 287 ETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEKAIKRDLSRT-----KF 341
+ E +G + R +W +L ++ + SP + I+ D+SRT +F
Sbjct: 35 QVESDEGGNSSTRPYVWAVLLNAPPRNADEYIRYVRQGPSPMAQKIQNDVSRTLVVESQF 94
Query: 342 IPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMK----V 397
SL +L AY ++ Y QGM +A+ + C+ E QAF +L++ +
Sbjct: 95 HSRVSQSSLSRLLNAY-VWKRGALYVQGMNVLASPFLYACKSENQAFQFFDRLLQNECPL 153
Query: 398 YGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFP 457
Y LP + G+ D LE D +LY +L+ +G+ + ++A LT+ A P
Sbjct: 154 Y-----VLPNIDGVHRGAKLLDKCLEVLDHRLYTYLLSKGLTAKIYALPSILTLSACTAP 208
Query: 458 LEFVLRIMDIVILEGI 473
L L I D + GI
Sbjct: 209 LSEALTIWDFLFAYGI 224
>CE10236 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 808
Score = 63.2 bits (152), Expect = 1e-09
Identities = 70/299 (23%), Positives = 123/299 (40%), Gaps = 27/299 (9%)
Query: 213 FDLILNRFIQNETELELRDDKEREHAKEGTKTLREEYDSL-----LDHADKELVQYDWPF 267
FD R ++ + L D++E AK ++ L L L KE+ D
Sbjct: 71 FDEFGFRKQDDDHDPNLGDEEETSSAKHLSEPLENSTHKLKLISYLQDVHKEVK--DDVL 128
Query: 268 WSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSP 327
WS ++ ++ D ++L E GIP +R +W L+ + K
Sbjct: 129 WSHILG--PELKTDRFEELLKE--GGIPHSMRPFLWPRLSGATKKQKDAKYTYESVLQQC 184
Query: 328 HEKA------IKRDLSRT--------KFIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFI 373
+ I+RDL RT K EG ++L +LK + P +GY QGMG I
Sbjct: 185 AQDKPSIGVQIERDLLRTLPNNICFWKKNSEG-IEALRRILKCVAFIYPDLGYCQGMGVI 243
Query: 374 ATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHL 433
TL+L C EE F ++T L++ + + + GL L++ + P L L
Sbjct: 244 VATLLLYCSEE-TTFWMMTALIEDILPPNFYTQTLLGLQADERVSRHLMKCHVPDLNKAL 302
Query: 434 IRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLI 492
+ ++ W LT+F F +LR+ D + G ++ + ++++ + ++
Sbjct: 303 EDYEVEVSLLTVSWLLTLFGSVFRTRVMLRVWDFIFYSGGVNIFRVIISILKMKEQEIV 361
>YOL112w [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 492
Score = 61.2 bits (147), Expect = 5e-09
Identities = 75/326 (23%), Positives = 127/326 (38%), Gaps = 60/326 (18%)
Query: 238 AKEGTKTLREEYDSLLDHADKELVQYDWPFWSKLVHNFSDIVKDD-------SKKLETEV 290
+K+G +EEYD ++ + + + L+ N ++ D+ + +L V
Sbjct: 85 SKKGYFISQEEYDKWWTEYNRYTERRKKKWENFLLKNKIELHNDNPLVYPARTDELSKFV 144
Query: 291 GKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHE--------KAIKRDLSRT--- 339
KGIP + RG W + E +AI+RDL RT
Sbjct: 145 RKGIPAEWRGNAWWYFAGGQRQLDANVGVYDRLKSDCREGAVSGKDMEAIERDLYRTFPD 204
Query: 340 --KFIPEGKTD-------SLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSL 390
F E + SL VL A+S+YD +GY Q M F+ L+L EEE +AF +
Sbjct: 205 NIHFHKESFQNGEPAIIRSLRRVLMAFSVYDKTIGYCQSMNFLVGLLLLFMEEE-KAFWM 263
Query: 391 LTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRS---------- 440
L + Y L ++ + G + ++E P++++H+ +
Sbjct: 264 LVIITGKY-LPGVYESDLEGANVDQGVLVLCIKEYLPEIWSHIESSYMNGNGSTDQISGP 322
Query: 441 -------------TMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKN 487
T+ WF++ F P+E LRI D + E + K +L
Sbjct: 323 ASGEEYLCRLPTLTLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFLFKVAL------ 376
Query: 488 SRNLIILSFDSLLDFLKEDLFQHYAS 513
++ LS L+ + LF+ Y+S
Sbjct: 377 --GILKLSESEFLESKSQKLFRQYSS 400
>Hs18580214 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 761
Score = 61.2 bits (147), Expect = 5e-09
Identities = 62/235 (26%), Positives = 97/235 (40%), Gaps = 31/235 (13%)
Query: 282 DSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEKA---------- 331
D+ K + GIP + R +W L + +Y + +E++
Sbjct: 75 DALKAVARLSTGIPKEWRRKVW-LTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQ 133
Query: 332 IKRDLSRTKFIP----EGKTDS--LFSVLKAYSLYDPPVGYTQGMGFIATTLILNCE-EE 384
I +DL RT E + D L VL AY+ ++ VGY QG +A ++ E E
Sbjct: 134 IVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNE 193
Query: 385 WQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIR--------- 435
A ++ L+ F+ + L + + F LL P+L HL
Sbjct: 194 GDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKES 253
Query: 436 ----QGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLK 486
+ + +F QWFLT+FA P + VL+I D V EG E +L+ SL + K
Sbjct: 254 GGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAK 308
>YNL293w [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 633
Score = 60.1 bits (144), Expect = 1e-08
Identities = 75/287 (26%), Positives = 115/287 (39%), Gaps = 64/287 (22%)
Query: 268 WSKLVHNFSDIVKDDS--------KKLETEVGKGIPTQVRGIIW--------QLLTSSNY 311
W L+ V DDS ++L+ V KGIP + RG W +L +
Sbjct: 190 WQLLLEKSGLPVTDDSPSRFPSKSERLKRYVRKGIPAEWRGNAWWHFARGQEKLNKNKGV 249
Query: 312 KXXXXXXXXXXXXXSPHEKA------IKRDLSRT----------KFIPEGKT--DSLFSV 353
+P+EK I+RDL+RT EG SL V
Sbjct: 250 YSQLLRKMKQIKKQNPNEKQVQDLDIIERDLNRTFPDNIHFQSSLHNKEGPPIIKSLRRV 309
Query: 354 LKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVY--GLRDLFLPGM--- 408
L A+SLY+P +GY Q M F+A L+L +EE +AF +L + Y G+ ++ L G+
Sbjct: 310 LVAFSLYNPKIGYCQSMNFLAGLLLLFLDEE-RAFWMLVIITSRYLPGVHNINLEGVNID 368
Query: 409 -PGLMLKLYQF-------------------DTLLEENDPQLYNHLIRQGIRS----TMFA 444
LML + ++ T N L+N + + T+
Sbjct: 369 QGVLMLCVKEYIPEVWSYIKPSIDHHQKNNKTFSPSNKKVLFNMQKNEFLYRLPPITLCT 428
Query: 445 TQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNL 491
WF++ F P+E LRI D + E + K SL ++ + +L
Sbjct: 429 ASWFMSCFVGVVPIETTLRIWDCLFYEESHFLFKVSLAVLKLSEHDL 475
>At5g24390 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 528
Score = 59.7 bits (143), Expect = 1e-08
Identities = 44/178 (24%), Positives = 79/178 (43%), Gaps = 24/178 (13%)
Query: 350 LFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMP 409
L +VL+AY+L+DP +GY QGM + + ++ ++++AF MK R F
Sbjct: 319 LVAVLEAYALHDPEIGYCQGMSDLLSPILSVIPDDYEAFWCFVGFMK--KARQNFRVDEV 376
Query: 410 GLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIV- 468
G+ +L +++ D QLY HL + F + L MF + LE L + +++
Sbjct: 377 GITRQLNIVSKIIKSKDSQLYKHLEKVKAEDCFFVYRMVLVMFRRELTLEQTLHLWEVIW 436
Query: 469 -----ILEGI----------------ESMLKFSLTLMLKNSRNLIILSFDSLLDFLKE 505
I G+ E +L + + + R +II + S+ + L+E
Sbjct: 437 ADQAAIRAGMGKSSWSRRIKQRAPPTEDLLLYVVAASVLQRRKVIIEKYSSMEEILRE 494
>7299972 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 804
Score = 59.7 bits (143), Expect = 1e-08
Identities = 59/229 (25%), Positives = 99/229 (42%), Gaps = 27/229 (11%)
Query: 277 DIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHE------K 330
D++ ++KL V +GIP +R +W L+ + K + K
Sbjct: 148 DVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSK 207
Query: 331 AIKRDLSRTKFIPEGKTDSLFS------------VLKAYSLYDPPVGYTQGMGFIATTLI 378
I++DL R +P T++ FS +L+ + P +GY QG G I L+
Sbjct: 208 QIEKDLLR--ILP---TNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLL 262
Query: 379 LNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGI 438
L EEE AF ++ +++ + + G+ TL+ + L + I
Sbjct: 263 LFMEEE-NAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDI 321
Query: 439 RSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTL-MLK 486
++ WFLT+FA ++ ++RI D EG S++ F LTL MLK
Sbjct: 322 ELSLITLHWFLTLFANVVHMKILVRIWDWFFYEG--SIVLFQLTLGMLK 368
>7290543 [R] KOG1093 Predicted protein kinase (contains TBC and RHOD
domains)
Length = 840
Score = 59.7 bits (143), Expect = 1e-08
Identities = 66/239 (27%), Positives = 102/239 (42%), Gaps = 21/239 (8%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEKAIKRDLSRTKFI 342
+++L+ E +P +RG IW L + ++ I+ D+ R
Sbjct: 421 AEQLQREAAVDVPPLLRGPIWAALLEVVPNGSYAKIDKFTSTST--DRQIEVDIPRCHQY 478
Query: 343 ------PEGKTDSLFSVLKAYSLYDPPVGYTQGMGFI-ATTLILNCEEEWQAFSLLTKLM 395
P+G L +LKA+ P Y QG+ + A L LN E AF L K +
Sbjct: 479 DELLSSPDGHR-KLRRLLKAWVTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFI 537
Query: 396 KVYGLRDLFLPGMPGLMLK-LYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAY 454
Y L+ FL ++ + L +F L ++P L HL +FA WFLTMF++
Sbjct: 538 PKY-LQWFFLKDNSAVIKEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSH 596
Query: 455 KFPLEFVLRIMDIVILE--------GIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKE 505
FPL +L + D ++L GI + + TL L + N IL F L D + +
Sbjct: 597 VFPLHKILHLWDKLMLGDSSYPLFIGIAILRQLRSTL-LTSGFNECILLFSDLPDIVMD 654
>Hs22058425 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 641
Score = 59.3 bits (142), Expect = 2e-08
Identities = 44/148 (29%), Positives = 67/148 (44%), Gaps = 14/148 (9%)
Query: 353 VLKAYSLYDPPVGYTQGMGFIATTLILNCE-EEWQAFSLLTKLMKVYGLRDLFLPGMPGL 411
VL AY+ ++ VGY QG +A ++ E E A ++ L+ F+ + L
Sbjct: 366 VLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLRAL 425
Query: 412 MLKLYQFDTLLEENDPQLYNHLIR-------------QGIRSTMFATQWFLTMFAYKFPL 458
+ + F LL P+L HL + + +F QWFLT+FA P
Sbjct: 426 SVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPN 485
Query: 459 EFVLRIMDIVILEGIESMLKFSLTLMLK 486
+ VL+I D V EG E +L+ SL + K
Sbjct: 486 QTVLKIWDSVFFEGSEIILRVSLAIWAK 513
>Hs22062568 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 219
Score = 57.8 bits (138), Expect = 6e-08
Identities = 47/167 (28%), Positives = 76/167 (45%), Gaps = 18/167 (10%)
Query: 255 HADKELVQYDWPFWSKLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXX 314
H +L++ W ++ ++ + KK++ + KGIP+ +R W LL ++
Sbjct: 54 HPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQK 113
Query: 315 XXXXXXXXXXXSPHE----KAIKRDLSRT-----KFI-PEGK-TDSLFSVLKAYSLYDPP 363
+P + + I RDL R F+ P+G L VLKAY+LY P
Sbjct: 114 NSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPE 173
Query: 364 VGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPG 410
GY Q G +A L+++ E +AF L ++ +VY LPG G
Sbjct: 174 QGYCQAQGPVAAVLLMHLPPE-EAFWCLVQICEVY------LPGYYG 213
>At5g52590 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 338
Score = 57.8 bits (138), Expect = 6e-08
Identities = 41/162 (25%), Positives = 76/162 (46%), Gaps = 6/162 (3%)
Query: 348 DSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPG 407
+S+ +L YS Y+ +GY QGM + ++ E+E ++F LM+ G F
Sbjct: 127 NSMRDILLTYSFYNFDLGYCQGMSDYLSPILFVMEDESESFWCFVALMERLGPN--FNRD 184
Query: 408 MPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDI 467
G+ +L+ L+E D L+N+ + F +W L F +F E +++ ++
Sbjct: 185 QNGMHTQLFALSKLVELLDSPLHNYFKENDCLNYFFCFRWILIQFKREFEYEKTMQLWEV 244
Query: 468 VILEGI-ESMLKFSLTLMLKNSRNLII---LSFDSLLDFLKE 505
+ + E + +LK R+ I+ + FD+LL F+ E
Sbjct: 245 MWTHYLSEHFHLYVCVAVLKRCRSKIMGEQMDFDTLLKFINE 286
>YDL234c [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 746
Score = 57.4 bits (137), Expect = 7e-08
Identities = 64/285 (22%), Positives = 116/285 (40%), Gaps = 30/285 (10%)
Query: 232 DKEREHAKEGTKTLREEYDSLLDHADKELVQYD----WPFWSKLVHNFSDIVKDDSKKLE 287
D ++ + +TL EYD L K+ +Q+D +W+ + S V+ + LE
Sbjct: 405 DSSQDERVQIDQTLAAEYDQLKLTWSKDFLQFDDEDEEEYWNDQLFRISKDVRRCDRNLE 464
Query: 288 T---EVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEKAIKRDLSRTKFIPE 344
G+P + QL + N SP E A +
Sbjct: 465 IFQYNTIDGLPPPPQ----QLPANEN------------NSTSP-ESANDESDDADDGVRN 507
Query: 345 GKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLF 404
L ++L Y++Y+ +GY QGM + + + + +EEW+ F T M + + F
Sbjct: 508 PHLIHLQNILITYNVYNTNLGYVQGMTDLLSPIYVIMKEEWKTFWCFTHFMDI--MERNF 565
Query: 405 LPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRI 464
L G+ ++ L++ P+L HL + + F + L F +F +E ++ I
Sbjct: 566 LRDQSGIHEQMLTLVELVQLMLPELSEHLNKCDSGNLFFCFRMLLVWFKREFEMEDIMHI 625
Query: 465 MD--IVILEGIESMLKFSLTLMLKNSRNLI--ILSFDSLLDFLKE 505
+ + L F L ++ KNS+ ++ + FD +L F E
Sbjct: 626 WENFWTFYYSSQFQLFFMLAILQKNSQAILQHLNQFDQILKFFNE 670
>7299317 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 3052
Score = 57.4 bits (137), Expect = 7e-08
Identities = 46/160 (28%), Positives = 72/160 (44%), Gaps = 29/160 (18%)
Query: 353 VLKAYSLYDPPVGYTQG-----------------MGF-IATTLILNCEEEWQAFSLLTKL 394
+L Y+ Y+P VGY Q GF + LIL ++ + S+ +
Sbjct: 175 ILLGYARYNPEVGYCQVSAPSRIFVCCVHFTHIIQGFNMLGALILQVMDKEEEESMKVMI 234
Query: 395 MKVYGL--RDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIR---------QGIRSTMF 443
V G+ F M GL + F L++ P+L HL R + + +F
Sbjct: 235 YLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVF 294
Query: 444 ATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTL 483
QWFLTMF P+ VLR+ D+V++EG + +L+ +L L
Sbjct: 295 TMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVL 334
>SPBC651.03c [T] KOG2595 Predicted GTPase activator protein
Length = 373
Score = 56.6 bits (135), Expect = 1e-07
Identities = 54/207 (26%), Positives = 93/207 (44%), Gaps = 13/207 (6%)
Query: 341 FIPEGKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGL 400
F+ L +L + P + Y QG+ IA L+L A L+ L+ Y L
Sbjct: 91 FLLRKHRSQLTKLLSVVFKHYPELCYYQGLHDIAQILLLTLPFS-HALPLMEHLV-FYRL 148
Query: 401 RDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKF-PLE 459
RD LP + G + +L +++ DP LY +LI+ I+ FA W +T FA+ +
Sbjct: 149 RDFMLPTLDGTVKQLQLILAVIKARDPTLYEYLIKADIQ-CYFALSWLITWFAHDVSDIS 207
Query: 460 FVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLFQHYASKENPEE 519
V R+ D I +++ ++L N ++I L +D+ DL Y K P
Sbjct: 208 VVCRLFDFFISSHPLTVVYTCAQVVLDNRTSIIELLWDN----SGADLLHSYLCK-LPAS 262
Query: 520 YDIDRFISDSL----EIKLTPLQLERY 542
++++ I ++ + + L L+RY
Sbjct: 263 INVNQLIKNTCATISAVPFSSLPLDRY 289
>At5g53570 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 550
Score = 55.8 bits (133), Expect = 2e-07
Identities = 33/119 (27%), Positives = 56/119 (46%), Gaps = 2/119 (1%)
Query: 350 LFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMP 409
L ++L+AY++YDP +GY QGM + + ++ E+ +AF MK R F
Sbjct: 340 LVAILEAYAMYDPEIGYCQGMSDLLSPILAVISEDHEAFWCFVGFMK--KARHNFRLDEA 397
Query: 410 GLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIV 468
G+ +L +++ D QLY HL F + L MF + E L + +++
Sbjct: 398 GIQRQLSIVSKIIKNKDSQLYKHLENLQAEDCSFVYRMVLVMFRRELSFEQTLCLWEVM 456
>CE02529 [R] KOG1093 Predicted protein kinase (contains TBC and RHOD
domains)
Length = 826
Score = 55.1 bits (131), Expect = 4e-07
Identities = 52/215 (24%), Positives = 88/215 (40%), Gaps = 9/215 (4%)
Query: 294 IPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHEKAIKRDLSRTKFIPEGKT-----D 348
IPTQ R +W L N ++ ++ D+ R T +
Sbjct: 449 IPTQ-RADVWCTLLDINETKWRDYLNLDVLASHSSDRQLEVDIPRCHQYDSYMTTPAIQE 507
Query: 349 SLFSVLKAYSLYDPPVG--YTQGMGFIATTLIL-NCEEEWQAFSLLTKLMKVYGLRDLFL 405
SL VLK + + Y QG +AT +L N + AF+ + Y +
Sbjct: 508 SLRKVLKGWQIVTESQHFVYWQGCDSLATPFLLANMSKPHVAFACFKEFTYRYCHKFYLK 567
Query: 406 PGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIM 465
+ L F L+ DP LY HL G + +FA WFLT FA++ PL ++ +
Sbjct: 568 DNSEVIKEYLGIFYHLVAYTDPVLYKHLKINGFDAELFAIPWFLTCFAHELPLSKLVLLW 627
Query: 466 DIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLL 500
D ++ G L +L ++ + L+ ++F+ ++
Sbjct: 628 DETMMHGNAFPLMIALAMLNRLRDKLLAVNFNEMI 662
>Hs21361637 [R] KOG4567 GTPase-activating protein
Length = 400
Score = 53.9 bits (128), Expect = 8e-07
Identities = 42/158 (26%), Positives = 72/158 (44%), Gaps = 19/158 (12%)
Query: 326 SPHEKAIKRDLSRTKFIPEG---KTDSLFSVLKAYSLYDPPVGYTQGM----GFIATTLI 378
SPH+ + L+ + +P G + + +L Y+ +P + Y QGM G + T
Sbjct: 184 SPHKNSAPSSLNEYEVLPNGCEAHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFA 243
Query: 379 LNCEEEWQ------AFSLLTKLMKVYGLRDLFLPGMP----GLMLKLYQFDTLLEENDPQ 428
+ EW+ F T LM +RD F+ + G+ K+ + + L++ D +
Sbjct: 244 TDPNSEWKEHAEADTFFCFTNLMAE--IRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVE 301
Query: 429 LYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMD 466
LY L Q I+ FA +W + + +F L V+RI D
Sbjct: 302 LYLKLQEQNIKPQFFAFRWLTLLLSQEFLLPDVIRIWD 339
>Hs4758564_1 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 498
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/248 (21%), Positives = 98/248 (38%), Gaps = 15/248 (6%)
Query: 283 SKKLETEVGKGIPTQVRGIIWQLLTS---------SNYKXXXXXXXXXXXXXSPHEKAIK 333
S KL V KGIP +RG +W +L + Y+ + ++
Sbjct: 90 SSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVR 149
Query: 334 RDLSRTKFIPE---GKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSL 390
L F + K LF +L AYS Y+P VGY + + I +L EE AF
Sbjct: 150 TTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEE-DAFWA 208
Query: 391 LTKLM--KVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWF 448
L +L+ + + L P + Q + ++ ++ P+ H ++G+ +
Sbjct: 209 LVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGCL 268
Query: 449 LTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLTLMLKNSRNLIILSFDSLLDFLKEDLF 508
L L LR+ D+ ++EG + ++ + + + L+ S L L+ F
Sbjct: 269 LRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFF 328
Query: 509 QHYASKEN 516
+A ++
Sbjct: 329 DTWAMNDD 336
>HsM12232451 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 674
Score = 53.1 bits (126), Expect = 1e-06
Identities = 43/152 (28%), Positives = 68/152 (44%), Gaps = 11/152 (7%)
Query: 328 HEKAIKRDLSRT----KFIPEGKTDS----LFSVLKAYSLYDPPVGYTQGMGFIATTLIL 379
+ I++D++RT KF EG+ + L +L Y +YD +GY QGM + + L+
Sbjct: 390 YRSLIEKDVNRTDRTNKFY-EGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLY 448
Query: 380 NCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIR 439
E E AF M + F M G+ +L Q TLL D ++L Q
Sbjct: 449 VMENEVDAFWCFASYMD--QMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSG 506
Query: 440 STMFATQWFLTMFAYKFPLEFVLRIMDIVILE 471
F +W L F +F +LR+ +++ E
Sbjct: 507 YLYFCFRWLLIRFKREFSFLDILRLWEVMWTE 538
>At3g49350 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 554
Score = 53.1 bits (126), Expect = 1e-06
Identities = 32/119 (26%), Positives = 57/119 (47%), Gaps = 2/119 (1%)
Query: 350 LFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMP 409
L +VL+AY+LYDP +GY QGM + + ++ ++ + F MK R F
Sbjct: 347 LVAVLEAYALYDPDIGYCQGMSDLLSPILSVIPDDHEVFWCFVGFMK--KARHNFRLDEV 404
Query: 410 GLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIV 468
G+ +L +++ D QLY HL + F + + MF + L+ L + +++
Sbjct: 405 GIRRQLNIVSKIIKSKDSQLYRHLEKLQAEDCFFVYRMVVVMFRRELTLDQTLCLWEVM 463
>Hs21362084 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 691
Score = 52.8 bits (125), Expect = 2e-06
Identities = 43/152 (28%), Positives = 68/152 (44%), Gaps = 11/152 (7%)
Query: 328 HEKAIKRDLSRT----KFIPEGKTDS----LFSVLKAYSLYDPPVGYTQGMGFIATTLIL 379
+ I++D++RT KF EG+ + L +L Y +YD +GY QGM + + L+
Sbjct: 407 YRSLIEKDVNRTDRTNKFY-EGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLY 465
Query: 380 NCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIR 439
E E AF M + F M G+ +L Q TLL D ++L Q
Sbjct: 466 VMENEVDAFWCFASYMD--QMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSG 523
Query: 440 STMFATQWFLTMFAYKFPLEFVLRIMDIVILE 471
F +W L F +F +LR+ +++ E
Sbjct: 524 YLYFCFRWLLIRFKREFGFLDILRLWEVMWTE 555
>SPAC1952.17c [R] KOG4567 GTPase-activating protein
Length = 541
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/140 (26%), Positives = 72/140 (51%), Gaps = 17/140 (12%)
Query: 353 VLKAYSLYDPPVGYTQGMGFIATTL--ILNCEEEWQ--------AFSLLTKLMKVYGLRD 402
+L Y+ +P +GY QGM I L +L + ++ AF L T++M +RD
Sbjct: 177 ILFIYAKLNPGIGYVQGMNEILAPLYYVLATDPTYENYYLCECDAFFLFTQMM--VQVRD 234
Query: 403 LFLPGMP-----GLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFP 457
L+ + G+ + +F L++ D +L+ +L + I T ++ +WF + + +FP
Sbjct: 235 LYEKTLDHDSDHGIHFLMSKFTERLKKYDYELWENLEEKQIHPTYYSFRWFTCLLSQEFP 294
Query: 458 LEFVLRIMDIVILEGIESML 477
L V+R+ D +I + +++ L
Sbjct: 295 LPDVIRLWDSIIADQMKARL 314
>Hs20548703_1 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 213
Score = 52.0 bits (123), Expect = 3e-06
Identities = 32/119 (26%), Positives = 51/119 (41%), Gaps = 2/119 (1%)
Query: 349 SLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGM 408
+L +L Y++ P V Y QGM +A+ ++ + E AF +MK L F P
Sbjct: 59 ALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMK--RLAANFHPDG 116
Query: 409 PGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDI 467
+ K LL DP Y +L G F +W L +F + LR++++
Sbjct: 117 RAMATKFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEV 175
>SPAC23D3.03c [TR] KOG2223 Uncharacterized conserved protein contains TBC domain
Length = 472
Score = 51.2 bits (121), Expect = 5e-06
Identities = 64/275 (23%), Positives = 102/275 (36%), Gaps = 36/275 (13%)
Query: 270 KLVHNFSDIVKDDSKKLETEVGKGIPTQVRGIIWQLLTSSNYKXXXXXXXXXXXXXSPHE 329
+++ N+ D +K S + +GIP++VRG +W+ +N K E
Sbjct: 194 EILRNWPDALK--SSRYAGIWRQGIPSRVRGRVWEKAIGNNLKLDYQSFFNARANAQKRE 251
Query: 330 KAIKR------------------DLSRTK-----FIPEGKTD-SLFSVLKAYSLYDPPVG 365
A K DL T F EG L +L+AYS Y
Sbjct: 252 AAEKAEQMNNANQFREDVCALELDLQSTMPHYSLFHTEGPLRRDLIGLLRAYSYYRFDTS 311
Query: 366 YTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLFLPGMPGLMLKLYQFDTLLEEN 425
Y G FI L+LN AF+ L L+ L+ ++ L F L++N
Sbjct: 312 YIPGTSFIGALLLLNMNLT-SAFNCLANLLDKPFLQAVYTQDTSSLKSFYQTFLDTLKKN 370
Query: 426 DPQLYNH-LIRQGIRSTMFATQWFLTMFAYKFPLEFVLRIMDIVILEGIESMLKFSLT-- 482
+P+L H LI+ + F +F E RI+D + E ++ +
Sbjct: 371 EPELATHLLIKLELVPDDFVYPLLRKLFIPMVSPEIASRILDCYVFEEDSFFIQLLMAVF 430
Query: 483 ------LMLKNSRNLIILSFDSLLDFLKEDLFQHY 511
L++ +SR ++ D ED F H+
Sbjct: 431 KLLKPKLLVDDSRLVLSALLFENWDLGPEDEFMHF 465
>At3g59570 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 549
Score = 51.2 bits (121), Expect = 5e-06
Identities = 34/141 (24%), Positives = 63/141 (44%), Gaps = 1/141 (0%)
Query: 345 GKTDSLFSVLKAYSLYDPPVGYTQGMGFIATTLILNCEEEWQAFSLLTKLMKVYGLRDLF 404
G + +L Y+ DP GY QGM + + + E+ AF L++ +
Sbjct: 410 GNLGRMSDILAVYAWVDPATGYCQGMSDLVSPFVFLFEDNADAFWCFEMLIR-RTRANFQ 468
Query: 405 LPGMPGLMLKLYQFDTLLEENDPQLYNHLIRQGIRSTMFATQWFLTMFAYKFPLEFVLRI 464
+ G G+M +L +L+ D ++++HL R G S FA + L +F + LR+
Sbjct: 469 MEGPTGVMDQLQSLWRILQLTDKEMFSHLSRIGAESLHFAFRMLLVLFRRELSFNKALRM 528
Query: 465 MDIVILEGIESMLKFSLTLML 485
++ + +L S + +L
Sbjct: 529 WEVGNSSAVCFVLPVSCSFIL 549
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.312 0.132 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,893,697
Number of Sequences: 60738
Number of extensions: 1978853
Number of successful extensions: 9896
Number of sequences better than 1.0e-05: 75
Number of HSP's better than 0.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 9704
Number of HSP's gapped (non-prelim): 108
length of query: 707
length of database: 30,389,216
effective HSP length: 114
effective length of query: 593
effective length of database: 23,465,084
effective search space: 13914794812
effective search space used: 13914794812
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)