ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV3273 good T KOG2128 Signal transduction mechanisms Ras GTPase-activating protein family - IQGAP
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV3273 1105955 1101474 -1494
(1494 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL242c [T] KOG2128 Ras GTPase-activating protein family - IQGAP 639 0.0
SPAC4F8.13c [T] KOG2128 Ras GTPase-activating protein family - I... 222 4e-57
Hs4506787 [T] KOG2128 Ras GTPase-activating protein family - IQGAP 110 2e-23
Hs5729887 [T] KOG2128 Ras GTPase-activating protein family - IQGAP 107 2e-22
ECU10g1740 [T] KOG2128 Ras GTPase-activating protein family - IQGAP 74 2e-12
7303337 [Z] KOG2046 Calponin 64 2e-09
Hs22046424 [T] KOG2128 Ras GTPase-activating protein family - IQGAP 60 2e-08
SPBC17D1.07c [T] KOG2128 Ras GTPase-activating protein family - ... 52 5e-06
>YPL242c [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 1495
Score = 639 bits (1647), Expect = 0.0
Identities = 453/1543 (29%), Positives = 740/1543 (47%), Gaps = 102/1543 (6%)
Query: 1 MSVLTGSPGKSDSINTRMQEYMKNINKDSQPVLKQXXXXXXXXXXXLKGILSSTKSPKNT 60
M+ +GSP K + N+ + Y++N+ + P L+ + S K +
Sbjct: 1 MTAYSGSPSKPGNNNSYLNRYVENLGTNVTPPLRPQSSSKINSSLNIAS--PSHLKTKTS 58
Query: 61 YSGSPGKENFNNVTAELSFILKNSPTKPSYFXXXXXXXXXXXXXXXXXXXXXXXXYQEFL 120
S S V + +S + + P K Y EFL
Sbjct: 59 ASNSSATILSKKVESSVSKLKPSLPNK----------LVGKYTVDLSNYSKIELRYYEFL 108
Query: 121 VRIEEAKQWIEAIIHEELPSALELATTKCMSDGVYLAKLVATVKPELVKKIIPTGDRLMY 180
R+ E K WIEA+I E LPS +EL + +GV+LAKL + P+L I P GD+L +
Sbjct: 109 CRVSEVKIWIEAVIEEALPSEIELCVGDSLRNGVFLAKLTQRINPDLTTVIFPAGDKLQF 168
Query: 181 AHTQNINAFLELVNYIAVPDLFKFELNDLYDRKNIPKVFETIHATASLLSAQYGTIIPQM 240
HTQNINAF LV ++ VPD F+FEL DLY++KNIP+VFET+H S+++ ++ P +
Sbjct: 169 KHTQNINAFFGLVEHVGVPDSFRFELQDLYNKKNIPQVFETLHILISMINKKWPGKTPAL 228
Query: 241 QNLTGQIDVSIDDIKLCQRKVPGVHAFRSFN---QFGXXXXXXXXXXQKGLLD------- 290
N++GQI + ++I C++ P + F+S + GL+
Sbjct: 229 TNVSGQISFTKEEIAACKKAWPRIRDFKSLGTNINTAPASPEEPKEKRSGLIKDFNKFER 288
Query: 291 -----SAVLQSPVKLKTEPEVCIPESPKTPTRYSSA-------IVHDIRQFNPSLSETKP 338
+L +P K T+ + TP+ Y+ A +V + R+F P +P
Sbjct: 289 PNIPVEEILITPRKNITDAN--CSDFSNTPSPYNEAPKMSNLDVVVEKRKFTP----IEP 342
Query: 339 LSLSYPTESSPQRLKYSP--DRTFSYYSPGVSRRLSYRTEDIGYFNRKRHQWNYDFDYYD 396
SL PT S L+YSP +++ SYYSP +S+ L+Y TE ++ R+ D +YY
Sbjct: 343 -SLLGPTPS----LEYSPIKNKSLSYYSPTISKYLTYDTE---FYTRRSRAREEDLNYYQ 394
Query: 397 TYRYGSTQYSPKRRERMTETEFLDTVTHLQALLRGLNTRYDVHLKIITLKHSNTRFAELQ 456
T++Y + YSP RRERMTE +FL+ V LQ + RG+NTR++++++ L Q
Sbjct: 395 TFKYSPSHYSPMRRERMTEEQFLEKVVQLQNICRGVNTRFNLYIQKRLLNLFEQDILRFQ 454
Query: 457 ALCKGAVIRGQHQNFVQNHKPN---EALVTLQARLRGSIQRDVFDHFRLRLIKRENYILY 513
A +G R ++ + + +Q+R++GS R +D + L + +
Sbjct: 455 ACLRGNKFRVLSSMYLPIRRAKIDVPHVEAIQSRIKGSRIRYKYDKLKFTLSRFSCTVEL 514
Query: 514 LKTQLKGSAQRKLTQEKLRYKSIYGDTFSVLQAVIRAKLQRGNFMSYHNISNIVSSEASA 573
L+ + + KL I + LQ+ +RA R MS + N
Sbjct: 515 LQAYCRSKLLKTTVNTKLNDIEISHYPLTKLQSYMRASYVRKKVMSLNTKLNDERESIMK 574
Query: 574 LQALSRGRIVR------LRMMEASSGDLQIKLQALLRGAFQRSKLQRV-----KEVMSCD 622
A+ RG +VR L + + KLQ+L+RG F RS L + KE +C+
Sbjct: 575 FSAIIRGNVVRCSEDAILSAVHDVHKENISKLQSLIRGIFTRSCLASIIYSLGKE--NCN 632
Query: 623 QFQNFGPILKGYIVARRYTD--APSKVANEIV-SFNAVVKGMLTRFAMELIIDIAEQNNI 679
Q ++G V + AP +E V +V+G+L R+ ++L+ DI E NN+
Sbjct: 633 IIQ-LSACIRGNAVRHKVQSLFAPENNLSETVHDLQGLVRGILVRYTLDLVDDIVEYNNL 691
Query: 680 DSLQSKVLGYLIRKRVSQKKSFYKMRESEIIIIQKNIRRYQLQNAYKVLMSTGSPKLSTV 739
Q+ G L+R+ + QK SFYK +I+IQ IR+ ++AY L+ +P L V
Sbjct: 692 ALFQAFSRGALVRESLDQKSSFYKRNVRSVIMIQSWIRKSLQRSAYLELLDCPNPSLWAV 751
Query: 740 RKFVHILNQSDNELFSANLQKLKANINDVNDEVGELQESLRKKVLMKDSLEK---RRIDV 796
+KFVH+LN + A I +V +++ Q SL + + K+ L K +++++
Sbjct: 752 KKFVHLLNGT-------------ATIEEVQNQLESCQASLDSENMKKERLLKSIRQQLNI 798
Query: 797 CKFLTPAGRQQLEIQFNAISSDNISANLKSLYGKAGFLLQVDSFYWHLLAKGDPRFCVTN 856
L G + + IS I + Y K ++LQVD YW LL +P F N
Sbjct: 799 NGVLDKFGLLKDKDHELGISDSTIPKSKYQKYEKLFYMLQVDPSYWKLLYLKEPEFVAKN 858
Query: 857 LPKLFAPIRGAIGDRENSLLIKVIGDLLVEEIDESSTLNDFLVNDDAVWIQVLQNYLTSF 916
+ F + + DRE S + + ++L I+E+ ++ FL N W +LQ++L
Sbjct: 859 VYMTFGTVNQRMNDRERSYFTRFVCEMLQNAINEAPSIESFLDNRSQFWQTILQDFLRR- 917
Query: 917 RSKEILTAFAQLYKYLDSNAIDFESDPSKIYAKLHPTAPPQLAHEAIEDSSTSKRFIKNM 976
S E + + YL +DFESDP KIY ++H + PQ ++D+ST +FI N+
Sbjct: 918 ESPEFFSIIVPVLDYLSDPVVDFESDPYKIYQEIHGFSSPQHC-SPVDDASTKNKFIDNL 976
Query: 977 TSLWGAVELVCAVLDHIVSSTRNDLKYLASRAYRSSANKDTEESSALSAISKIVVDNFIF 1036
LW A+E+V + V + +++YL ++ + +A+K+ EE +L AIS I+V+ F+
Sbjct: 977 RCLWHAIEMVAEIYTRKVHTIPVEIRYLCTKIFCYAADKNIEEIDSLRAISSILVNVFVS 1036
Query: 1037 VALMKRS--DFSSSTVGLNYDEKARVLTETLKVIFALKTFDGYFSPLNQYLVQSHNQFSD 1094
L+ R + S V N ++K +L ++L +F +K FDG+ PLNQY + D
Sbjct: 1037 EYLVNREYYGYKDSNVQKN-NQKIDILMKSLATVFEIKNFDGFLDPLNQYANEIKPHIKD 1095
Query: 1095 ILTELLMEPEESKEYETMVYKDMANNSKPSLMIYHQSFIKILEKLEGTLEELPHDDPMVK 1154
+L +L++PE +E + ++Y DM + S P L + + ++I K E L E P D +
Sbjct: 1096 VLYNVLVDPEYEQEGDRLIYLDMVSPS-PKLELLTEKVLEISGKFEEYLNEFPEADILHD 1154
Query: 1155 ILSKIQIEFDKTSVNGQSQLTISLDPSAYKVTLNNSRSDLMYTEAKQGLCYLMQVEEVNS 1214
IL K D +S ++T+ LD SAY+ +++ + +Y + K+ Y+MQ+E+V++
Sbjct: 1155 ILEK---NLDNSSFPRSGRVTLELDASAYRFLVSDDKMRKIYDQVKRAFVYMMQIEDVDT 1211
Query: 1215 NLTDLLVSEVLPEDEIAFQQLIAQNPSIANTLSEKHGDIINYAEFKKFLMYRIKELTVLG 1274
NL DL +S +LP+DE F + QNP I + + + Y K + +I EL G
Sbjct: 1212 NLYDLSISTILPQDEPNFANFLEQNPKIRDDPMIQKLKPLKYFTLKNVTLKKIHELESTG 1271
Query: 1275 IIDKS-NDYQFLLVDIANTIKTRSCIKGLNRSEMELMTSVYDSLNDKLRNTKLLLDAMDT 1333
S N Q L DIANTIK + E+ + +++ + + L +
Sbjct: 1272 TFCSSDNKLQNFLNDIANTIKNPNYAIDYVTQEIYITKETLTKISEMNHSLDIELSRLKK 1331
Query: 1334 AITKSIKEIQSLHDYTPAKKSGFGHKLKDVYQKNHKKSHEAEAGMNYKWSNKQLFELGVL 1393
+ +IK+ Q D++P KS FG+ K+ +K + GM +KW+ KQL+E GVL
Sbjct: 1332 HVDHTIKDFQKAKDFSPVHKSKFGN-FKNAVKKVQGRERSELQGMKFKWNTKQLYERGVL 1390
Query: 1394 SKVTGNGAKNXXXXXXXXXXXXXQYVDLKFSTRDGEVFGIELIDNKNKFDSNLQSVV--- 1450
+ G + K ST DG FGI++ID + D V
Sbjct: 1391 KTIRGEKLAELTVKVFGSSGPKFPDIIFKISTSDGSRFGIQMIDKRKGPDKRYSDDVDSF 1450
Query: 1451 KFSELIEKEAADRHSTISILGRKEKMVLNVGKLLDLLVDSFFR 1493
F +LI+ + + T + +V+N +LL L+V F++
Sbjct: 1451 SFKDLIKTQVEPKIETWKLF--HSNVVVNNSQLLHLIVSFFYK 1491
>SPAC4F8.13c [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 1489
Score = 222 bits (565), Expect = 4e-57
Identities = 314/1403 (22%), Positives = 591/1403 (41%), Gaps = 153/1403 (10%)
Query: 118 EFLVRIEEAKQWIEAIIHEELPSALELATTKCMSDGVYLAKLVATVKPELVKKIIPTGDR 177
++L R++EAK+WIE + +L + + +GV LA LV +P+ + KI + +
Sbjct: 39 DYLCRVDEAKKWIEECLGTDLGPTSTFEQS--LRNGVVLALLVQKFQPDKLIKIFYSNE- 95
Query: 178 LMYAHTQNINAFLELVNYIAVPDLFKFELNDLYDRKNIPKVFETIHATASLLSAQ--YGT 235
L + H+ NIN FL+ ++ I +P++F FEL D+Y+ KN+PKV IHA + LS Q
Sbjct: 96 LQFRHSDNINKFLDFIHGIGLPEIFHFELTDIYEGKNLPKVIYCIHALSYFLSMQDLAPP 155
Query: 236 IIPQMQNLT-GQIDVSIDDIKLCQRKV--PGVHAFRSFNQFGXXXXXXXXXXQKGLLDSA 292
+I +NL+ DVSI +L Q V P A + A
Sbjct: 156 LIKSDENLSFTDEDVSIIVRRLRQSNVILPNFKALSADFMLRASPVSSRTPSPTRFPKHA 215
Query: 293 VLQSPVKLKTEPEVCIPESPKT-PT------------------RYSSAIVHDIRQFNPSL 333
Q+ L + I SP T PT R + + + QFN
Sbjct: 216 RFQT---LNSSDSASIYSSPYTSPTLEFSKKDASARSDILKMHRRTKSATPSLEQFNEPY 272
Query: 334 SETKPLSLSYPTESS---PQRLKYSPDRTF-SYYSPGVSRRLSYRTEDIGYFNRKRHQWN 389
+T P S S E S P K R+F + +S RR + + G R
Sbjct: 273 KQTLP-SHSIEFEDSFFQPPSQKGHMQRSFLTTFSAPTRRREALFSTTSGLSQRS----- 326
Query: 390 YDFDYYDTYRYGSTQYSPKRRERMTE-----TEFLDTVTHLQALLRGLNTRYDVHLKIIT 444
D + R R+ + E +V LQA++RG +R ++
Sbjct: 327 -PVDEKIVNAIQACGRGVLVRLRLVDMLQSLVEQSSSVVLLQAVIRGYISRNTYRIRKKA 385
Query: 445 LKHSNTRFAELQALCKGAVIRGQHQNFVQNHKPNEALVTLQARLRGSIQRDVFDHFRLRL 504
+Q++ + +IR Q++ V + +++ TLQ+ +RG R + RL
Sbjct: 386 YDELVNWVTSIQSISRAYLIRAQYRKVVLQEEATKSIQTLQSIIRGGFYRRKYHSLIERL 445
Query: 505 IKRENYILYLKTQLKGSAQRKLTQEKLRYKSIYGDTFSVLQAVIRAKLQRGNFMSYHNIS 564
+ +++ G R L Y F+ +Q+++RA + R + N
Sbjct: 446 DLFTPSFVLIQSSALGFLTRHAIVNMLDNLYNYIPLFNRMQSILRANMFRNE---WSNFL 502
Query: 565 NIVSSEASALQALSRGRIVR---LRMMEASSGDLQ--IKLQALLRGAFQR----SKLQRV 615
+ V S + ++ +GR++R R+ + G+L IKLQ L RG R KL+++
Sbjct: 503 DSVQSFPVSFHSICKGRLIRDSINRLNGSLLGELDNFIKLQNLSRGFMIRRAFKEKLEKL 562
Query: 616 KEVMSCDQFQNFGPILKGYIVARRYT---DAPSKVANEIVSFNAVVKGMLTR-------- 664
K S F I++ +++ + D+ K ++ ++ +G +TR
Sbjct: 563 KA--STSSFIALQAIVRAFLLRKNLESIYDSFQKSHLSVIKAQSLYRGFITRTKIDYCND 620
Query: 665 FAMELIIDIAEQNN-----------------IDS-------LQSKVLGYLIRKRVSQK-K 699
+ ++ + DI + +DS LQS + GYL R + S+K +
Sbjct: 621 YLLKRLPDIVFMQSAVRAILLRDDVNYTEVQLDSFIPEIVLLQSLIRGYLSRNKFSRKLQ 680
Query: 700 SFYKMRESEIIIIQKNIRRYQLQN-AYKVLMSTGSPKLSTVRKFVHILNQSDNEL-FSAN 757
+F+K E+ I+ K+I R + + AY+ L + +P + TV+ FVH+L+ ++ +
Sbjct: 681 NFHKNMENPIVA--KSIFRGRQEGLAYRELATAKNPPVMTVKNFVHLLDDTNFDFEEEVL 738
Query: 758 LQKLKANI-------NDVNDEVGELQESLRKKVLMKDSLEKRRIDVCKFLT--PAGRQQL 808
L+K++ I ++ + EL + V K SL+ DV K G+Q
Sbjct: 739 LEKMRKEIVQQVRDNEEIEVHINELDVKIALLVKNKISLD----DVLKHHNKYKFGKQST 794
Query: 809 E-IQFNAISS---DNISANLKSLYGKAGFLLQVD-----SFYWHLLAKGDPRFCVTNLPK 859
E ++ N +S +N S LY ++LQ + +++ L +G + +
Sbjct: 795 EYLKINTLSMKSLNNSSRKFLELYQCFFYVLQTNEMYLANYFQALKTEGTSSVKIRHAVY 854
Query: 860 LFAPIRG-AIGDRENSLLIKVIGDLLVEEIDESSTLNDFLVNDDAVWIQVLQNYLTSFRS 918
L I G RE LL++ I ++ E ++ D L++DD VW + Y R
Sbjct: 855 LVLQIFGHGSNRREEVLLLRFISQVIKLEAALVNSSQD-LLSDDCVWKLLFTGYRGDVRE 913
Query: 919 KEI-LTAFAQLYKYL-DSNAIDFESDPSKIYAKLHP-----TAPPQLAHE-AIEDSSTSK 970
++ T +++K L N +DFE +P ++ +P T P+L A++ T
Sbjct: 914 VKLWKTILGRIHKVLVADNHLDFEINPLTLFKSFNPEVASQTDSPKLTLSLAMQHPPTRN 973
Query: 971 RFIKNMTSLWGAVELVCAVLDHIVSSTRNDLKYLASRAYRSSAN--KDTEESSALSAISK 1028
++ + L + L + + L Y A++ S + I K
Sbjct: 974 LYVSRLRELRKLCQSFLVALSKNIENIPYALCYTAAQLKNSLQRYFPAAHKEEIFGVIGK 1033
Query: 1029 IVVDNFIFVALMKRSDFS--SSTVGLNYDEKARVLTETLKVIFALKTFD----GYFSPLN 1082
V ++ L+ +F ++ + L+ L IF++++ D G+F PL+
Sbjct: 1034 FVYWAYVAPVLVSPDNFKLVDGSITALQRKNLYTLSSILSEIFSIESCDSKQLGFFRPLS 1093
Query: 1083 QYLVQSHNQFSDILTELLMEPEESKEYETMVYKDMANNSKPSLMIYHQSFIKILEKLEGT 1142
+++ S +L L+ + +E ++D+ N +P + + + I +
Sbjct: 1094 EFIEVSKQDTMLMLERLVDVVDPEVYFEFDAFEDLVNTKRPVIYMKRDDILGIYSSIAYV 1153
Query: 1143 LEEL-PHD--DPMVKILSKI--QIEFDKTSVNGQSQLTISLDPSAYKVTLNNSRSDLMYT 1197
++ + P D DP+ +++ + E D V ++ + + L+P + ++ +
Sbjct: 1154 IDSIAPPDVNDPLRAVVNSLGPVSEQDNDFVQDETDVKLELNPKFCTIENPVAQERTLIV 1213
Query: 1198 EAKQGLCYLMQVEEVNSNLTDLLVSEVLPEDEIAFQQLIAQNPSIANTLSEKHGDII--- 1254
+ K+ + ++++++ NL ++LV V DE A+Q L+A+ + D I
Sbjct: 1214 QTKRYILFIIRIQN-GLNLLEILVKPVTDSDEAAWQNLLAEESEKNARNYDLFDDSIFSM 1272
Query: 1255 NYAEFKKFLMYRIKELTVLGIIDKSNDYQFLLVDIANTIKTRSCIKGLNRSEMELMTSVY 1314
++AE K + I E+ LG ++ N+YQ ++ IA I+ +S + + + EL
Sbjct: 1273 SFAELKYTALSNIVEMEKLGFANRRNNYQDMVNSIALDIRNKS--RRRMQRQRELDAGHQ 1330
Query: 1315 DSLNDKLRNTKLLLDAMDTAITKSIKEIQSLHDYTPAKKSGFGHKLKDVYQKNHKKSHEA 1374
LN LR + LD+ + + I++ KK + + ++ +KS
Sbjct: 1331 SLLN--LREKRAFLDSQLKSYNEYIEQAMETLQSKKGKKKLIPFSKQYFHMRDLRKSGRV 1388
Query: 1375 EAGMNYKWSNKQLFELGVLSKVT 1397
++K+ +L++ GVL ++
Sbjct: 1389 PRFGSFKYPALKLYDRGVLVSIS 1411
>Hs4506787 [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 1657
Score = 110 bits (274), Expect = 2e-23
Identities = 173/801 (21%), Positives = 329/801 (40%), Gaps = 105/801 (13%)
Query: 674 AEQNNIDSLQSKVLGYLIRKRVSQKKSFYKMRESEIIIIQKNIRRYQLQNAYKVLMSTGS 733
+ ++ + +QS + RKR + +++ ++II IQ IR + ++ YK L++
Sbjct: 804 SHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAED 863
Query: 734 PKLSTVRKFVHILNQSDNEL-FSANLQKLKANINDVNDEVGELQESLRKKVLMKDSLEKR 792
P + VRKFVH+L+QSD + +L K++ + + +L+ L + L K
Sbjct: 864 PPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKN 923
Query: 793 RIDV------CKFLTPAGRQQLEIQFNAISSDNISANLKSL----------YGKAGFLLQ 836
+I + K LT ++QL + + + LK+L Y +LLQ
Sbjct: 924 KITLQDVVSHSKKLTKKNKEQLS---DMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQ 980
Query: 837 VDSFYWHLLAKGDPRFCVTNL--PKLFAPIRGAIGDRENSLLIKVIGDLLVEEIDESSTL 894
+ Y L P+ T +F A RE LL+++ L EEI
Sbjct: 981 TNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFKTALQEEIKSKVDQ 1040
Query: 895 NDFLVNDDAVWIQVLQNYLTSFRSKEILTAFAQ--LYKYLDSNAIDFESDPSKIY----- 947
+V + I+++ ++ R + L + + +D +++ ++DP IY
Sbjct: 1041 IQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVN 1100
Query: 948 ---------AKLHPTAPPQ--LAHEAIEDSSTSKRFIKNMTSLWGA-VELVCAVLDHIVS 995
+KL P+ LAHE ++ S I+NM ++ + + + +D I
Sbjct: 1101 QMESQTGEASKLPYDVTPEQALAHEEVKTRLDSS--IRNMRAVTDKFLSAIVSSVDKIPY 1158
Query: 996 STRNDLKYLASRAYRSSANKDTEESSALSAISKIVVDNFIFVALMKRSDFS----SSTVG 1051
R K L + D E L I ++ ++ A++ F S+
Sbjct: 1159 GMRFIAKVLKDSLHEKF--PDAGEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQ 1216
Query: 1052 LNYDEKARV--LTETLKVIFALKTFDG---YFSPLNQYLVQSHNQFSDILTELLMEPEES 1106
L D++ + + + L+ + K F G + S +N+YL QS+ +F PE
Sbjct: 1217 LTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQTACDVPELQ 1276
Query: 1107 KEYETMVYKDMANNSKPSLMIYHQSFIK----ILEKLEGTLEELPHDDPMVKILSKIQIE 1162
++ Y D+ +KP + I I +L+ + E H+DP+ ++L +
Sbjct: 1277 DKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPE--HNDPIHELLDDLGEV 1334
Query: 1163 FDKTSVNGQSQLTI------SLDPSAYKVTLNN-------------SRSDLMYTEAKQGL 1203
S+ G+S + +L + +TL N +R+ L+ T K+ +
Sbjct: 1335 PTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNT--KRLI 1392
Query: 1204 CYLMQVEEVNSNLTDLLVSEVLPEDEIAFQQLI-------AQNP-SIANTLSEKHGDIIN 1255
+++ + LT++L + E E Q+ + A+ P + + S K +
Sbjct: 1393 VDVIRFQP-GETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKKSKSVKEDSNLT 1451
Query: 1256 YAEFKKFLMYRIKELTVLGIIDKSNDYQFLLVDIANTIKTRSCIKGLNRSEMELMTSVYD 1315
E K+ + +K+LT LG +D N YQ L+ DIA I+ + + ++E+ + Y
Sbjct: 1452 LQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRKAELVKLQQTYA 1511
Query: 1316 SLNDKLRNTKLLLDAMDTAITKSIKEIQSLHDYTPAKKSGFGHKLKDVYQKNHKKSHEAE 1375
+LN K +D + I + + A K K +++ K KK
Sbjct: 1512 ALNSKATFYGEQVDYYKSYIKTCLDNL--------ASKGKVSKKPREMKGKKSKK----- 1558
Query: 1376 AGMNYKWSNKQLFELGVLSKV 1396
++ K++ +L E GVL ++
Sbjct: 1559 --ISLKYTAARLHEKGVLLEI 1577
Score = 85.5 bits (210), Expect = 6e-16
Identities = 55/145 (37%), Positives = 85/145 (57%), Gaps = 12/145 (8%)
Query: 118 EFLVRIEEAKQWIEAIIHEELPSALELATTKCMSDGVYLAKLVATVKPELV--KKIIPTG 175
E+L +EEAK+W+EA + E+LP EL + + +GVYLAKL P++V KKI
Sbjct: 42 EYLCHLEEAKRWMEACLGEDLPPTTELE--EGLRNGVYLAKLGNFFSPKVVSLKKIYDRE 99
Query: 176 DR------LMYAHTQNINAFLELVNYIAVPDLFKFELNDLYDRKNIPKVFETIHATASLL 229
L + HT N+ +L ++ I +P +F E D+YDRKN+P+ IHA SL
Sbjct: 100 QTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHA-LSLY 158
Query: 230 SAQYGTIIPQMQNLTGQIDVSIDDI 254
+ G + PQ+Q+L G++D + ++I
Sbjct: 159 LFKLG-LAPQIQDLYGKVDFTEEEI 182
>Hs5729887 [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 1575
Score = 107 bits (266), Expect = 2e-22
Identities = 203/976 (20%), Positives = 395/976 (39%), Gaps = 162/976 (16%)
Query: 616 KEVMSCDQFQNFGPILKGYIVARRYTDAPSKVANEIVSFNAVVKGMLTR----FAMELII 671
+E++ Q + GPIL+ AR+ + +V A KG R + I
Sbjct: 661 EELLLRFQATSSGPILREEFEARK--SFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFI 718
Query: 672 DIAEQNNIDSLQSKVLGYLIRKRVSQKKSFYKMRESEIIIIQKNIRRYQLQNAYKVLMST 731
D +++ +QS RK + +++ +EI+ IQ +R + ++ YK L+ +
Sbjct: 719 D--NTDSVVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGS 776
Query: 732 GSPKLSTVRKFVHILNQSD----NELFSANL-----------QKLKANINDVNDEVGELQ 776
+P L+ +RKFV++L+QSD EL A L Q+L+ ++N ++ ++G L
Sbjct: 777 ENPPLTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLL- 835
Query: 777 ESLRKKVLMKDSLEKRRIDVCKFLTPAGRQQLEIQFNAISSDNISANLKSL--------- 827
++ ++ ++D I K L ++EI N +DN +KSL
Sbjct: 836 --VKNRITLEDV-----ISHSKKLNKKKGGEMEILNN---TDN--QGIKSLSKERRKTLE 883
Query: 828 -YGKAGFLLQVDSFYWHLLAKGDPRFCVTNL--PKLFAPIRGAIGDRENSLLIKVIGDLL 884
Y + +LLQ + Y L P+ T +F A RE LL+K+ L
Sbjct: 884 TYQQLFYLLQTNPLYLAKLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTAL 943
Query: 885 VEEIDESSTLNDFLVNDDAVWIQVLQNYLTSFRSKEILTAFAQ--LYKYLDSNAIDFESD 942
EEI +V + I+++ ++ R + L + + +D ++ ++
Sbjct: 944 EEEIKSKVDQVQDIVTGNPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTN 1003
Query: 943 PSKIY------AKLHPTAPPQLAHEAIEDSSTSKRFIKNMTSLWGAVELVCAVLDHIVSS 996
P ++Y + +L ++ + + + +KN L ++E + V D +++S
Sbjct: 1004 PVEVYKAWVNQLETQTGEASKLPYDVTTEQALTYPEVKN--KLEASIENLRRVTDKVLNS 1061
Query: 997 TRND-------LKYLASRAYRSSANK--DTEESSALSAISKIVVDNFIFVALMKRSDFS- 1046
+ L+Y+A S K D E L + ++ ++ A++ F
Sbjct: 1062 IISSLDLLPYGLRYIAKVLKNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDI 1121
Query: 1047 -SSTVG--LNYDEKARV--LTETLKVIFALKTFDG---YFSPLNQYLVQSHNQFSDILTE 1098
T G +N D++ + + + L+ + K F+G + S +N YL +++ +F E
Sbjct: 1122 IDMTAGGQINSDQRRNLGSVAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKE 1181
Query: 1099 LLMEPEESKEYETMVYKDMANNSKP-------------SLMIYHQSFI-----KILEKLE 1140
PE +++ Y D+ SKP SL++ HQ I +L +L
Sbjct: 1182 ACNVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELL 1241
Query: 1141 GTLEELPHDDPMVKILSKIQIE-FDKTSVNGQSQLT---ISLDPSAYKVTLNNSRSDLMY 1196
G+L E+P + L + ++ D N SQL+ ISL + S+ D+
Sbjct: 1242 GSLGEVP---TVESFLGEGAVDPNDPNKANTLSQLSKTEISL--------VLTSKYDIED 1290
Query: 1197 TEAKQGLCYLMQVEEV---------NSNLTDLLVSEVLPEDEIAFQQLIAQNPSIANTLS 1247
EA +++ +++ + LT++L + + E+ + I +
Sbjct: 1291 GEAIDSRSLMIKTKKLIIDVIRNQPGNTLTEILETPATAQQEVDHATDMVSRAMIDSRTP 1350
Query: 1248 E--KHG-DIINYAEF-----KKFLMYRIKELTVLGIIDKSNDYQFLLVDIANTIKTRSCI 1299
E KH +I A+ K+ + ++ L G + N YQ +L +IA I+ +
Sbjct: 1351 EEMKHSQSMIEDAQLPLEQKKRKIQRNLRTLEQTGHVSSENKYQDILNEIAKDIRNQRIY 1410
Query: 1300 KGLNRSEMELMTSVYDSLNDKLRNTKLLLDAMDTAITKSIKEIQSLHDYTPAKKSGFGHK 1359
+ L ++E+ + ++LN K + ++ DT I + ++ + K G G
Sbjct: 1411 RKLRKAELAKLQQTLNALNKKAAFYEEQINYYDTYIKTCLDNLKRKNTRRSIKLDGKG-- 1468
Query: 1360 LKDVYQKNHKKSHEAEAGMNYKWSNKQLFELGVLSKVTG---NGAKNXXXXXXXXXXXXX 1416
+ A+ K++ +L E GVL + N KN
Sbjct: 1469 ----------EPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQTNQFKNVTFDIIATEDVGI 1518
Query: 1417 QYVDLKFSTRDGEVFGIELIDNKNKFDSNLQSVVKFSELIEKEAADRHSTISILGRKEKM 1476
V KF G+E+ K N+Q +++ ++ ++++ +K+
Sbjct: 1519 FDVRSKF-------LGVEM----EKVQLNIQDLLQM----------QYEGVAVMKMFDKV 1557
Query: 1477 VLNVGKLLDLLVDSFF 1492
+NV L+ LL F+
Sbjct: 1558 KVNVNLLIYLLNKKFY 1573
Score = 87.8 bits (216), Expect = 1e-16
Identities = 57/152 (37%), Positives = 87/152 (56%), Gaps = 12/152 (7%)
Query: 118 EFLVRIEEAKQWIEAIIHEELPSALELATTKCMSDGVYLAKLVATVKPELV--KKIIPTG 175
E+L +EEAK+W+E + EELP EL + + +GVYLAKL P++V KKI
Sbjct: 39 EYLCHLEEAKRWMEVCLVEELPPTTELE--EGLRNGVYLAKLAKFFAPKMVSEKKIYDVE 96
Query: 176 DR------LMYAHTQNINAFLELVNYIAVPDLFKFELNDLYDRKNIPKVFETIHATASLL 229
L + HT N +L + I +P +F E D+YDRKNIP++ IHA SL
Sbjct: 97 QTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIFYPETTDVYDRKNIPRMIYCIHA-LSLY 155
Query: 230 SAQYGTIIPQMQNLTGQIDVSIDDIKLCQRKV 261
+ G I PQ+Q+L G++D + ++I ++++
Sbjct: 156 LFKLG-IAPQIQDLLGKVDFTEEEISNMRKEL 186
>ECU10g1740 [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 1027
Score = 73.6 bits (179), Expect = 2e-12
Identities = 53/148 (35%), Positives = 75/148 (49%), Gaps = 7/148 (4%)
Query: 118 EFLVRIEEAKQWIEAIIHEELPSALELATTKCMSDGVYLAKLVATVKPELVKKIIPTGDR 177
E+L R+EEAK WI +P + E + M GV L + VK +
Sbjct: 41 EYLCRLEEAKSWIGEFTI--VPESFEEFEEE-MRKGVMLTDICKVFAANSVKNVF-VDST 96
Query: 178 LMYAHTQNINAFLELVNYIAVPDLFKFELNDLYDRKNIPKVFETIHATASLLSAQYGTII 237
L Y HT NIN FL+ + +P+ F FE+ DLY++KN KV IHA A LLS++ I
Sbjct: 97 LQYRHTDNINYFLDGITRFGLPEYFHFEVIDLYEKKNFVKVIYCIHALAHLLSSK--GIS 154
Query: 238 PQMQNLTGQIDVSIDDIKLCQRKVPGVH 265
+++ G+I S DD+ +V VH
Sbjct: 155 RNIRSAKGKI-FSQDDMARADVQVEKVH 181
>7303337 [Z] KOG2046 Calponin
Length = 184
Score = 63.5 bits (153), Expect = 2e-09
Identities = 36/101 (35%), Positives = 56/101 (54%), Gaps = 4/101 (3%)
Query: 124 EEAKQWIEAIIHEELPSALELATTKCMSDGVYLAKLVATVKPELVKKIIPTGDRLMYAHT 183
+EA++WIEAII E+ P+ + DG L KL+ + P V K+ +G + +
Sbjct: 21 KEAQEWIEAIIAEKFPAGQSYEDV--LKDGQVLCKLINVLSPNAVPKVNSSGGQFKFM-- 76
Query: 184 QNINAFLELVNYIAVPDLFKFELNDLYDRKNIPKVFETIHA 224
+NIN F + + VPD+ F+ DLY++K+I V TI A
Sbjct: 77 ENINNFQKALKEYGVPDIDVFQTVDLYEKKDIANVTNTIFA 117
>Hs22046424 [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 492
Score = 60.5 bits (145), Expect = 2e-08
Identities = 65/291 (22%), Positives = 119/291 (40%), Gaps = 17/291 (5%)
Query: 674 AEQNNIDSLQSKVLGYLIRKRVSQKKSFYKMRESEIIIIQKNIRRYQLQNAYKVLMSTGS 733
A + I +Q+ + R++ ++ +++ + I+ IQ R + Q+ Y++L+
Sbjct: 115 ANLDAIIKIQAWARMWAARRQYLRRLHYFQKNVNSIVKIQAFFRARKAQDDYRILVHAPH 174
Query: 734 PKLSTVRKFVHILNQSDNE-LFSANLQKLKANINDVNDEVGELQESLRKKVLMKDSLEKR 792
P LS VR+F H+LNQS + L A L KL+ + +L++ L + L K
Sbjct: 175 PPLSVVRRFAHLLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIMDIKIGLLVKN 234
Query: 793 RIDV------CKFLTPAGRQQLEIQFNAISSDNISANLK------SLYGKAGFLLQVDSF 840
RI + CK LT ++QL + + K Y +LLQ
Sbjct: 235 RITLQEVVSHCKKLTKRNKEQLSDMMVLDKQKGLKSLSKEKRQKLEAYQHLFYLLQTQPI 294
Query: 841 YWHLLAKGDPRFCVTNLPK--LFAPIRGAIGDRENSLLIKVIGDLLVEEIDESSTLNDFL 898
Y L P+ T + +F+ A RE LL+++ L EEI +
Sbjct: 295 YLAKLIFQMPQNKTTKFMEAVIFSLYNYASSRREAYLLLQLFKTALQEEIKSKVEQPQDV 354
Query: 899 VNDDAVWIQVLQNYLTSFRSKEILTAF--AQLYKYLDSNAIDFESDPSKIY 947
V + ++++ + + R + L + L+ + +DP +Y
Sbjct: 355 VTGNPTVVRLVVRFYRNGRGQSALQEILGKVIQDVLEDKVLSVHTDPVHLY 405
>SPBC17D1.07c [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 962
Score = 52.4 bits (124), Expect = 5e-06
Identities = 37/155 (23%), Positives = 72/155 (45%), Gaps = 5/155 (3%)
Query: 119 FLVRIEEAKQWIEAIIHEELPSALELATTKCMSDGVYLAKLVATVKPELVKKIIPTGDRL 178
+L + EAK+W+E + E + + + +G L +L P+L P ++
Sbjct: 63 YLCSVHEAKKWLEEETNNEYQNLDDFVDA--LVNGKVLCQLAFKYYPKLASNWKPRY-QI 119
Query: 179 MYAHTQNINAFLELVNYIAVPDLFKFELNDLYDRKNIPKVFETIHATASLLSAQYGTIIP 238
+T +NAF +++I + F+FE DL R NIPKV +HA + LL + +
Sbjct: 120 SERNTVYLNAFFHFLDFIGMFTPFRFETKDLVRRFNIPKVIYCLHALSYLL--DFLEVTR 177
Query: 239 QMQNLTGQIDVSIDDIKLCQRKVPGVHAFRSFNQF 273
+ +L G++ + + +++ + + F F
Sbjct: 178 HVPSLYGKLRIKKSQLNTATKEISLLKKAKKFPNF 212
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.134 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,007,640
Number of Sequences: 60738
Number of extensions: 3279458
Number of successful extensions: 10159
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 10089
Number of HSP's gapped (non-prelim): 27
length of query: 1494
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1375
effective length of database: 23,161,394
effective search space: 31846916750
effective search space used: 31846916750
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)