ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV3322 good A KOG2051 RNA processing and modification Nonsense-mediated mRNA decay 2 protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV3322 1128147 1124905 -1081
(1081 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YHR077c [A] KOG2051 Nonsense-mediated mRNA decay 2 protein 743 0.0
SPAC19A8.08 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein 192 2e-48
Hs11693132 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein 179 3e-44
At2g39260 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein 156 2e-37
CE27527_2 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein 129 3e-29
7290872 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein 107 1e-22
>YHR077c [A] KOG2051 Nonsense-mediated mRNA decay 2 protein
Length = 1089
Score = 743 bits (1918), Expect = 0.0
Identities = 385/804 (47%), Positives = 523/804 (64%), Gaps = 15/804 (1%)
Query: 2 AWTGIDVFPDKAKKLDSSIKRNTGFIKKLKQGIAKESKTGLLNDIREVSLEKYLSEIITT 61
AW G +VFP K+KKLDSSIKRNTGFIKKLK+G K S++ LL D+ E SLEKYLSEII T
Sbjct: 16 AWNGEEVFPLKSKKLDSSIKRNTGFIKKLKKGFVKGSESSLLKDLSEASLEKYLSEIIVT 75
Query: 62 TNEALFKNSGKGDDIVAVVEIVSGLHQRFNMDFTLPLIESFLFIFETSSDEAETEKDKTT 121
E L K DD++A VEI+SGLHQRFN FT PL+ +FL FE S + E+E+D+
Sbjct: 76 VTECLLNVLNKNDDVIAAVEIISGLHQRFNGRFTSPLLGAFLQAFENPSVDIESERDELQ 135
Query: 122 RTNVLKACTRVLIELHLTGVLPSLDDL-NKSKLPPFVVKRYSKKEPIVFIVLREVLNYKF 180
R +K RV EL+L GV +LDD+ +K +P F+ K+ +K+P++F +LRE+LNYKF
Sbjct: 136 RITRVKGNLRVFTELYLVGVFRTLDDIESKDAIPNFLQKKTGRKDPLLFSILREILNYKF 195
Query: 181 KEALTTPVAILILKKYPELLSEEVSDMDNLINSEELKTLLRSLFKIYKDIVFQQTVELNK 240
K TT +A +KK+ L ++ + D+LI +LK L+SLFK + D F + EL+K
Sbjct: 196 KLGFTTTIATAFIKKFAPLFRDDDNSWDDLIYDSKLKGALQSLFKNFIDATFARATELHK 255
Query: 241 KTIKLMKEHHKAQIRTGKESSEYLDDFNELNPIFEKFSTVATALAEAFNVDPPELLDIEQ 300
K KL +EH K QIRTGK EY++++++L PIF +F T A L E F ++ PEL
Sbjct: 256 KVNKLQREHQKCQIRTGKLRDEYVEEYDKLLPIFIRFKTSAITLGEFFKLEIPELEGASN 315
Query: 301 S-LKEQEPSIITPASDWKEKQEPIWENEENRRFYENLADLSAAYATYDPEKTPSPEDVIA 359
LKE +IT + + +WENE+ R+FYE L D+S KT +V +
Sbjct: 316 DDLKETASPMIT--NQILPPNQRLWENEDTRKFYEILPDISKTVEESQSSKTEKDSNVNS 373
Query: 360 -----LFADFETVETKDEIDEISRRYWLQNLDNKATRKRLMKFFVECKDWSKISLYARFM 414
F D E + KD ID++S RYW LDNKATR R++KFF+E +DWSK+ +Y+RF+
Sbjct: 374 KNINLFFTDLEMADCKDIIDDLSNRYWSSYLDNKATRNRILKFFMETQDWSKLPVYSRFI 433
Query: 415 ANNENYLSEVKEELIQYLDSGFRSQLHSXXXXXXXXXFFAEMVKFMLIPSFMIFHKIRTL 474
A N Y+ E+ E I YLD+GFRSQLHS FF+EM+KF LIPSFMIFHKIRTL
Sbjct: 434 ATNSKYMPEIVSEFINYLDNGFRSQLHSNKINVKNIIFFSEMIKFQLIPSFMIFHKIRTL 493
Query: 475 AMNITVPNNIEILSTLFESFGKFLINTPEFKPQMEKMMVLIKEKKKDHLLTVNNKAALDN 534
M + VPNN+EIL+ L E GKFL+N PE+K MEKM+ LIK+KK D L +N K+AL+N
Sbjct: 494 IMYMQVPNNVEILTVLLEHSGKFLLNKPEYKELMEKMVQLIKDKKNDRQLNMNMKSALEN 553
Query: 535 LIILIYPPQLNVLNQEKRDLSPEQLFFITLIRRELDNVSLNSALKLILKASWNDPNVEKT 594
+I L+YPP + LN + ++PEQ F+ LIR EL ++ +KL+ KA W+D ++K
Sbjct: 554 IITLLYPPSVKSLNVTVKTITPEQQFYRILIRSELSSLDFKHIVKLVRKAHWDDVAIQKV 613
Query: 595 LLSLFSKPEKVSYQSLPKLANILTYLFKHYKSFTIKTVDTLLEKIQVGLESGEYSLNMAR 654
L SLFSKP K+SYQ++P L +L L+ + + F I+ +D +LE I+ GLE +Y NM R
Sbjct: 614 LFSLFSKPHKISYQNIPLLTKVLGGLYSYRRDFVIRCIDQVLENIERGLEINDYGQNMHR 673
Query: 655 VSQVKYLTELYNTSFLKFEVLLDTMYRILRFGYPSGQPNPFFINEGDLPDNYFRISLIST 714
+S V+YLTE++N +K +VLLDT+Y I+RFG+ + QPNPF++N D PDNYFRI L++T
Sbjct: 674 ISNVRYLTEIFNFEMIKSDVLLDTIYHIIRFGHINNQPNPFYLNYSDPPDNYFRIQLVTT 733
Query: 715 ILLGINRKSEFALKKLKIFIQFFEYYIFCKDQPLPNEVSFKVENVFALYPD------HSR 768
ILL INR KK K+ ++FFEYY F K+QPLP E F+V + F Y + R
Sbjct: 734 ILLNINRTPAAFTKKCKLLLRFFEYYTFIKEQPLPKETEFRVSSTFKKYENIFGNTKFER 793
Query: 769 SSDWSQCYEKLILLLKELGVTSAE 792
S + + +L LLK L ++
Sbjct: 794 SENLVESASRLESLLKSLNAIKSK 817
Score = 94.0 bits (232), Expect = 1e-18
Identities = 58/144 (40%), Positives = 82/144 (56%), Gaps = 14/144 (9%)
Query: 952 DREKEKKRIMEEFEKKLADDSERKAQADFDRQFQLMMDESLGSIKNETVQSVSMPM---H 1008
DR+ E KR+ EE+E+KL D+ ERKA+ + +RQFQ MM ES+ + K+E V + +P+
Sbjct: 946 DRDIEMKRMYEEYERKLKDEEERKAEEELERQFQKMMQESIDARKSEKVVASKIPVISKP 1005
Query: 1009 FSSQAP----KSDIPS-------ETPKGGKIPFMFLSRSGKKTQAHSINVPSETKFVSXX 1057
S Q P KS+ PS E K KI F FL++SGKKTQ+ + +P++ KFVS
Sbjct: 1006 VSVQKPLLLKKSEEPSSSKETYEELSKPKKIAFTFLTKSGKKTQSRILQLPTDVKFVSDV 1065
Query: 1058 XXXXXXXXXXXXXXKSIVMNRNFD 1081
K IV+ R+FD
Sbjct: 1066 LEEEEKLKTERNKIKKIVLKRSFD 1089
>SPAC19A8.08 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein
Length = 1049
Score = 192 bits (489), Expect = 2e-48
Identities = 191/825 (23%), Positives = 362/825 (43%), Gaps = 92/825 (11%)
Query: 15 KLDSSIKRNTGFIKKLKQGIAKESKTGLLNDIREVSLEKYLSEIITTTNEALFKNSGKGD 74
+LDSS+K+NT F+K+ K + E+ + +I+ +SL+K++ EI E + K
Sbjct: 36 QLDSSLKKNTAFMKRCKSSLTSENYDSFIKEIKTLSLKKFIPEITAAIVEGMMKCKAT-K 94
Query: 75 DIVAVVEIVSGLHQRFNMDFTLPLIESFLFI--------------FETSSDEAE-TEKDK 119
DI++ V+IV L+ RF+ FT P++ + FE +E E +EKD+
Sbjct: 95 DILSSVKIVWALNLRFSTAFTGPMLANLYCALYPNPGYSLCHESYFELKQNENEVSEKDR 154
Query: 120 TTRTNVLKACTRVLIELHLTGV----------LPSLDDLNKSKLPPFVVKRYSKKEPIVF 169
++ ++ R LIE L GV LPS D +K P+ ++ KK P+V
Sbjct: 155 SSHLLKVRPLLRFLIEFWLNGVVGTPEDFVSYLPSTDSNDKKFRKPWFEEQNLKK-PLVV 213
Query: 170 IVLREVLNYKFKEALTTPVAILILKKYPELLS------EEVSDMDNLINSEELKTLLRSL 223
++ ++++ +F L + L+ EL + +E ++ N +N +T LR
Sbjct: 214 LLFNDLMDTRFGFLLLPVLTSLVRTFSCELFTTEDFEDKETLELVNRLNPVVWRTYLRKS 273
Query: 224 FKIYKD---IVFQQTVELNKKTIKLMKEHHKAQIRTGKESSEYLDDFNE-LNPIFEKFST 279
Y D + Q+ L ++ K +E + E + L +F++ + F +++
Sbjct: 274 LNSYVDKLEVYCQKRKSLFEELNKQYQEQSIIRADPNNEKFQRLANFSKSIESEFSSYAS 333
Query: 280 VATALAEAFNVDPPELLDIEQSLKEQEPSIITPASDWKEKQE----PIWENEENRRFYE- 334
++ L + D EL +E++ S+ + + E +W++ E FYE
Sbjct: 334 LSEVLNRKASEDLLELNFMEKASSGTN-SVFNASGERSESANVETAQVWDDREQYFFYEV 392
Query: 335 -------NLADL-SAAYATYDP------EKTPSPEDVIALFADFETVETKDEID------ 374
++A++ S+ Y + E +D+ D T + +D
Sbjct: 393 FPNFNEGSIAEMKSSIYESSQEGIRSSSENNKKEDDLKDSTGDLNTTQVSSRVDNFLLKL 452
Query: 375 ------EISRRYWLQ--NLDNKATRKRLMKFFVECKDWSK--ISLYARFMANNENYLSEV 424
E++ L+ +L+ KA+R RL+K S + Y R SE
Sbjct: 453 PSMVSLELTNEMALEFYDLNTKASRNRLIKALCTIPRTSSFLVPYYVRLARILSQLSSEF 512
Query: 425 KEELIQYLDSGFRSQLHSXXXXXXXXX-----FFAEMVKFMLIPSFMIFHKIRTLAMNIT 479
L+ + F+ +H + +E+ KF L+P M+F + L +N
Sbjct: 513 STSLVDHARHSFKRMIHRKAKHEYDTRLLIVRYISELTKFQLMPFHMVFECYK-LCINEF 571
Query: 480 VPNNIEILSTLFESFGKFLINTPEFKPQMEKMMVLIKEKKKDHLLTVNNKAALDNLIILI 539
P ++E+L+ L ES G+FL+ PE K QM+ + I++KK L ++ L+N + +
Sbjct: 572 TPFDLEVLALLLESCGRFLLRYPETKLQMQSFLEAIQKKKLASALASQDQLVLENALHFV 631
Query: 540 YPPQLNVLNQEKRDLSPEQLFFITLIRRELDNVSLNSALKLILKASWNDPNVEKTLLSLF 599
PP+ ++ +K+ L E L+ + IR + DNV L L+ K W D + L +
Sbjct: 632 NPPKRGIIVSKKKSLKEEFLYDLIQIRLKDDNVF--PTLLLLRKFDWKDD--YQILYNTI 687
Query: 600 SKPEKVSYQSLPKLANILTYLFKHYKSFTIKTVDTLLEKIQVGLESGEYSLNMARVSQVK 659
+ + Y SL LA +L+ L+K + F I +D LE + + + ++ R++Q +
Sbjct: 688 MEVWNIKYNSLNALARLLSALYKFHPEFCIHVIDDTLESLFSAVNNSDHVEKQKRLAQAR 747
Query: 660 YLTELYNTSFLKFEVLLDTMYRILRFGYPSGQPNPFFINEG----DLPDNYFRISLISTI 715
+++EL L + + ++ +L P + F + ++ ++ FR+ LI +
Sbjct: 748 FISELCVIHMLDVRAITNFLFHLL----PLEKFESFLTMKASTLTNINNDMFRLRLIVVV 803
Query: 716 LLGINRKSEFALKKLKIFIQFFEYYIFCKDQP-LPNEVSFKVENV 759
L + K + Y + QP +P ++ ++ E+V
Sbjct: 804 LQTCGPSIIRSKTKKTMLTYLLAYQCYFLIQPEMPLDMLYEFEDV 848
>Hs11693132 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein
Length = 1272
Score = 179 bits (453), Expect = 3e-44
Identities = 197/860 (22%), Positives = 358/860 (40%), Gaps = 152/860 (17%)
Query: 15 KLDSSIKRNTGFIKKLKQGIAKESKTGLLNDIREVSLEKYLSEIITTTNEALFKNSGKGD 74
+LDSS+K+NT F+KKLK I ++ + L +D ++L KY++E + + EA K S
Sbjct: 163 RLDSSLKKNTAFVKKLKT-ITEQQRDSLSHDFNGLNLSKYIAEAVASIVEAKLKIS---- 217
Query: 75 DIVAVVEIVSGLHQRFNMDFTLPLIESFLFIFETSSDEAETEKDKTTRTNVLKACTRVLI 134
D+ V + S HQR+ DF L++ + FE +E KT L+ R +
Sbjct: 218 DVNCAVHLCSLFHQRY-ADFAPSLLQVWKKHFEARKEE------KTPNITKLRTDLRFIA 270
Query: 135 ELHLTGVLPSLDDLN--------------KSKLPPFVVKRYSKK--EPIVFIVLREVLNY 178
EL + G+ + L+ +S VV + + + I +V R+V +
Sbjct: 271 ELTIVGIFTDKEGLSLIYEQLKNIINADRESHTHVSVVISFCRHCGDDIAGLVPRKVKSA 330
Query: 179 KFKEALTTPVAILILKKYPELLSEEVSDMDNLINSEELKTLLRSLFKIYKDIVFQQTVEL 238
K L+ P + E++S E + E +L + L + ++++ Q T
Sbjct: 331 AEKFNLSFPPS--------EIISPEKQQPFQNLLKEYFTSLTKHLKRDHREL--QNTERQ 380
Query: 239 NKKTIKLMKEHHKAQIRTGKESSEYLDDFNELNPIFEKFSTVATALAEAFNVDPPELLDI 298
N++ + H K ++ S + + E ++K + +LA+ + + P+L
Sbjct: 381 NRRIL-----HSKGEL-----SEDRHKQYEEFAMSYQKLLANSQSLADLLDENMPDLPQD 430
Query: 299 EQSLKEQEPS--IITPASDWKEKQEP-IW-------------------------ENEENR 330
+ + +E P I TP + E IW +NE++
Sbjct: 431 KPTPEEHGPGIDIFTPGKPGEYDLEGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSC 490
Query: 331 RFYE-NLADLSAAYATYDPEKTPSPEDV------IALFADFETVETKDEIDEISRRY--- 380
+ E N D A + + ++ SP+D+ + + D +E DE ++++++
Sbjct: 491 QNKESNKDDTKEAKESKENKEVSSPDDLELELENLEINDDTLELEGGDEAEDLTKKLLDE 550
Query: 381 ----------------------------------------WLQNLDNKATRKRLMK--FF 398
+ N++ KA RK+L++ F
Sbjct: 551 QEQEDEEASTGSHLKLIVDAFLQQLPNCVNRDLIDKAAMDFCMNMNTKANRKKLVRALFI 610
Query: 399 VECKDWSKISLYARFMANNENYLSEVKEELIQYLDSGFRSQLH-----SXXXXXXXXXFF 453
V + + YAR +A +S+V E+L L FR + + F
Sbjct: 611 VPRQRLDLLPFYARLVATLHPCMSDVAEDLCSMLRGDFRFHVRKKDQINIETKNKTVRFI 670
Query: 454 AEMVKFMLIPSFMIFHKIRTLAMNITVPNNIEILSTLFESFGKFLINTPEFKPQMEKMMV 513
E+ KF + H ++ L + + ++IE+ TL E+ G+FL +PE + ++
Sbjct: 671 GELTKFKMFTKNDTLHCLKMLLSDFS-HHHIEMACTLLETCGRFLFRSPESHLRTSVLLE 729
Query: 514 LIKEKKKDHLLTVNNKAALDNLIILIYPPQLNVLNQEKRDLSPEQLFFITLIRRELDNVS 573
+ KK+ L ++N PP ++KR P Q + L+ ++L V+
Sbjct: 730 QMMRKKQAMHLDARYVTMVENAYYYCNPPPAEKTVKKKRP--PLQEYVRKLLYKDLSKVT 787
Query: 574 LNSALKLILKASWNDPNVEKTLLSLFSKPEKVSYQSLPKLANILTYLFKHYKSFTIKTVD 633
L+ + K W D V+ ++ V Y S+ +AN+L L + + I VD
Sbjct: 788 TEKVLRQMRKLPWQDQEVKDYVICCMINIWNVKYNSIHCVANLLAGLVLYQEDVGIHVVD 847
Query: 634 TLLEKIQVGLESGEYSLNMARVSQVKYLTELYNTSFLKFEVLLDTMYRILRFGY-PSGQP 692
+LE I++G+E + N R+S K+L ELYN ++ V+ T+Y FG P G P
Sbjct: 848 GVLEDIRLGMEVNQPKFNQRRISSAKFLGELYNYRMVESAVIFRTLYSFTSFGVNPDGSP 907
Query: 693 NPFFINEGDLPDNYFRISLISTIL--LGINRKSEFALKKLKIFIQFFEYY--------IF 742
+ D P++ FRI L+ TIL G + +KL F+ +F+ Y ++
Sbjct: 908 SSL-----DPPEHLFRIRLVCTILDTCGQYFDRGSSKRKLDCFLVYFQRYVWWKKSLEVW 962
Query: 743 CKDQPLPNEVSFKVENVFAL 762
KD P P ++ + + + L
Sbjct: 963 TKDHPFPIDIDYMISDTLEL 982
>At2g39260 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein
Length = 1029
Score = 156 bits (394), Expect = 2e-37
Identities = 140/579 (24%), Positives = 267/579 (45%), Gaps = 48/579 (8%)
Query: 202 EEVSDMDNLINSEELKTLLRSLFKIYKDIVFQQTVELNKKTIKLMKEHHKAQIRTGKESS 261
++ S + + + E+ KT L + F V L + K ++ KA+ + + SS
Sbjct: 180 KDTSVPEPIWDDEDTKTFYECLPDLR---AFVPAVLLGEAEPKSNEQSAKAKEKLSESSS 236
Query: 262 EYLDDFNELNPIFEKFSTVATALAEAFNVDPPELLDIEQSLKEQEPSIITPASDWKEKQE 321
E +++ E S + ++ + N + P+ E+ E+E + T KEK
Sbjct: 237 EVVENQQTTEDTTE-VSADSASMDDRSNAEQPK----EKEEVEKEKAKDTKKEKGKEK-- 289
Query: 322 PIWENEENRRFYENLADLSAAYATYDPEKTPSPEDVIALFADFETVETKDEIDEISRRYW 381
+ E + +E S A ++ P V ++D ID+++ Y
Sbjct: 290 ----DSEKKMEHEKEKGKSLDVANFERLLQRLPGCV-----------SRDLIDQLTVEYC 334
Query: 382 LQNLDNKATRKRLMK--FFVECKDWSKISLYARFMANNENYLSEVKEELIQYLDSGFRSQ 439
L++K RK+L+K F V ++ Y+R +A + + ++ L+Q L+ F S
Sbjct: 335 Y--LNSKTNRKKLVKALFNVPRTSLELLAYYSRMVATLASCMKDIPSMLVQMLEDEFNSL 392
Query: 440 LH-----SXXXXXXXXXFFAEMVKFMLIPSFMIFHKIRTLAMNITVPNNIEILSTLFESF 494
+H + F E+ KF ++P+ ++F ++ T +NI++ L E+
Sbjct: 393 VHKKDQMNIETKIRNIRFIGELCKFKIVPAGLVFSCLKACLDEFT-HHNIDVACNLLETC 451
Query: 495 GKFLINTPEFKPQMEKMMVLIKEKKKDHLLTVNNKAALDNLIILIYPPQLNVLNQEKRDL 554
G+FL +PE +M M+ ++ K L ++N L PP+ + + R
Sbjct: 452 GRFLYRSPETTLRMTNMLDILMRLKNVKNLDPRQSTLVENAYYLCKPPERSARISKVRP- 510
Query: 555 SPEQLFFITLIRRELDNVSLNSALKLILKASWNDPNVEKTLLSLFSKPEKVSYQSLPKLA 614
P + L+ +LD S+ + LK + K W++ E+ +L F K K Y + +A
Sbjct: 511 -PLHQYVRKLLFSDLDKDSIANVLKQLRKLPWSE--CEQYILKCFMKVHKGKYGQIHLIA 567
Query: 615 NILTYLFKHYKSFTIKTVDTLLEKIQVGLESGEYSLNMARVSQVKYLTELYNTSFLKFEV 674
++ + L +H+ F + VD +LE+I+VGLE EY R++ +++L ELYN + V
Sbjct: 568 SLTSGLSRHHDEFVVAVVDEVLEEIRVGLELNEYGAQQKRLAHMRFLGELYNYEHVDSSV 627
Query: 675 LLDTMYRILRFGYPSGQPNPFFINEGDLPDNYFRISLISTIL--LGINRKSEFALKKLKI 732
+ +T+Y L +G+ + + D P+++FR+ ++ +L G + K+L
Sbjct: 628 IFETLYLTLLYGHDTSEQEVL-----DPPEDFFRVRMVIILLETCGHYFDRGSSKKRLDQ 682
Query: 733 FIQFFEYYIFCKDQPLPNEVSFKVENVFA-LYPDHSRSS 770
F+ F+ YI K LP ++ F ++++FA L P+ +R S
Sbjct: 683 FLIHFQRYILSKGH-LPLDIEFDLQDLFANLRPNMTRYS 720
>CE27527_2 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein
Length = 1098
Score = 129 bits (323), Expect = 3e-29
Identities = 172/833 (20%), Positives = 332/833 (39%), Gaps = 128/833 (15%)
Query: 17 DSSIKRNTGFIKKLKQGIAKESKTGLLNDIREVSLEKYLSEIITTTNEALFKNSGKGDDI 76
+S++K+ T F+KK+K ++ + L+ ++ +++L K++ E+ + E K S DI
Sbjct: 1 NSTLKKTTSFMKKVKL-LSAATVPQLIEELSKLNLSKFVEEMASGIIETKLKLS----DI 55
Query: 77 VAVVEIVSGLHQRFNMDFTLPLIESFLFIFETSSDEAETEKDKTTRTNVLKACTRVLIEL 136
V E+ + +++ +F+ + F + + DK L+ L EL
Sbjct: 56 PKVTELCLAISAKYS-NFSEQMAGEFKKVLPVK------KSDKIANVAKLRVDIIFLAEL 108
Query: 137 HLTGVLPSLDDLNKSKLPPFVVKRYSKKEPI---VFIVLREVLNYKFKEALTTPVAILIL 193
L GV + L + + K + + + + + ++ + P+
Sbjct: 109 CLCGVFNEKEGLQVLGAVLSYLIQTDKTDFVNVGLLATVSRTVGWQIANIVPIPMDDA-- 166
Query: 194 KKYPELLSEEVSDMDNLINSEELKTLLRSLFKIYKDIVFQQTVELNKKTIKLMKEHHKAQ 253
+ E+ EE+ + L S E K +R LFK Y D ++ +T + K MK + +
Sbjct: 167 -ETVEIQDEELPESSAL--SVEQKKSIRELFKSYYDSLYSKTEKTCSARNKAMKRVKRQE 223
Query: 254 IRTGKESSEYLDDFNELNPIFEKFSTVATALAEAFNVDPPELLDIEQSLKEQEPSIITPA 313
G E N+L + +A ++ A V+ L + +E E + +
Sbjct: 224 RSRGDAGDEEKTTLNDLQSELDSLRKMAIEISSAIGVEMKPLKEEASDDEEDEAANLEMG 283
Query: 314 SDWKEKQEPIWENEENRRFYENLADLS--------------------------------- 340
E +W +EE + FYE+L DL
Sbjct: 284 RKLAEGAIKLWSDEETKAFYEDLIDLRQMVPKDLYKESEQRTLSKAKMAERIEDVDMENI 343
Query: 341 ----------AAYATYDPEKTPSPEDVIALFADFETVETKDE------------IDEISR 378
++ + EK +PED E V+ +E +D +
Sbjct: 344 NESGAMDAKRSSLQRGESEKETTPEDSQLQALLKEAVDASEERGVSKWQSFVLDLDHLVS 403
Query: 379 RY--------WLQNLDNKATRKRLMKFFVECKDWSKISL---YARFMANNENYLSEVKEE 427
+Y ++ NL+NK RKRL+K ++ S+I + YAR +A EN + ++ E
Sbjct: 404 KYSTDQAAIYFVSNLNNKGCRKRLVKLMIDPPP-SRIDVVPFYARLVATLENVMPDLTTE 462
Query: 428 LIQYLDSGFRSQLHSXXXXXXX----------XXFFAEMVKFMLIPSFMIFHKIRTLAMN 477
++ L FR L AE++KF +I +R L +
Sbjct: 463 IVTQLLEKFRGFLQQKPSSATAIIKVESKMVCVMMIAELMKFGVISRAEGLSCLRQLVYD 522
Query: 478 ITVPNNIEILSTLFESFGKFLINTPEFKPQMEKMMVLIKEKKKDHLLTVNNKAALDNLII 537
+ +++E+ +T ES G +L E +M++++ ++K K++ + +DN
Sbjct: 523 LR-GHSVEMTATFMESSGLYLYRHTESHAKMKRLLEVVK-AKRERMKDQRQAMLIDNAYF 580
Query: 538 LIYPPQLNVLNQEKRDLSPEQL---FFITLIRRELDNVSLNSALKLILKASWNDPNVEKT 594
PP+ + + + L E FI I +++ +++ LK + + W DP V
Sbjct: 581 TCLPPEDSKEERLRLKLDEEDTPMKRFIRHIILDINESTVDVFLKCLRRLEWYDPEVADY 640
Query: 595 LLSLFSKPEKVSYQSLPKLANILTYL--FKHYKSFTIKTVDTLLEKIQVGLES-GEYSLN 651
+ S + ++L +A+ + L H + + +D+ +E I++ LE+ G Y N
Sbjct: 641 AIRYLSSTWLLPIENLQHVASAIAGLCNLVHLQWIGMAVIDSTIETIRISLENPGVY--N 698
Query: 652 MARVSQVKYLTELYNTSFLKFEVLLDTMYRILRFGYPSGQPNPFFINEGDLPDNYFR-IS 710
S YL ELY+ +++L +Y+++ YP P+N +R +
Sbjct: 699 QWAHSAAVYLAELYSFELCDEDLVLKILYQLI--SYPE-------------PENSWRDLH 743
Query: 711 LISTILLGINRKSEFALK-----KLKIFIQFFEYYIFCKDQPLPNEVSFKVEN 758
I I + EF +K K++ F+ +F Y + K EV+ + N
Sbjct: 744 RIRMICAMLEILREFFMKGSGKIKMRYFLSYFHRYYYIKKDAWDQEVAEQQPN 796
>7290872 [A] KOG2051 Nonsense-mediated mRNA decay 2 protein
Length = 1241
Score = 107 bits (266), Expect = 1e-22
Identities = 101/411 (24%), Positives = 180/411 (43%), Gaps = 24/411 (5%)
Query: 370 KDEIDEISRRYWLQNLDNKATRKRLMK--FFVECKDWSKISLYARFMANNENYLSEVKEE 427
K+ ID + + L N + K RK+L + F V+ + +RF+A ++V +
Sbjct: 524 KELIDSAAIEFLL-NFNTKHQRKKLTRTIFSVQRTRLDILPYLSRFVAIVHMCNTDVATD 582
Query: 428 LIQYLDSGFRSQLH-----SXXXXXXXXXFFAEMVKFMLIPSFMIFHKIRTLAMNITVPN 482
L + L F+ +H + F E+VKF L F ++ L + +
Sbjct: 583 LAELLRKEFKWHIHKKNQLNIETKLKIVRFIGELVKFGLFKKFDALGCLKMLLRDFQ-HH 641
Query: 483 NIEILSTLFESFGKFLINTPEFKPQMEKMMVLIKEKKKDHLLTVNNKAALDNLIILIYPP 542
IE+ E G +L N + + M + + K + + A ++++ L+ PP
Sbjct: 642 QIEMACAFVEVTGVYLYNCRDARLLMNVFLDQMLRLKTATAMDSRHAAQIESVYYLVKPP 701
Query: 543 QLNVLNQEKRDLSPEQLFFITLIRRELDNVSLNSALKLILKASWNDPNVEKTLLSLFSKP 602
+ + R E + + LI EL +++ +K++ + W DP + SK
Sbjct: 702 ESSKREPMVRPAMHEYIRY--LIFEELCKQNVDRCIKMLRRIDWQDPETNCYAIKCLSKA 759
Query: 603 EKVSYQSLPKLANILTYLFKHYKSFTIKTVDTLLEKIQVGLESGEYSLNMARVSQVKYLT 662
+ +Q + LA++++ L + +D + E I+ GLE + R++ KYL
Sbjct: 760 YLLRFQLIRCLADLVSGLSSYQPRAVTIVIDNVFEDIRAGLEIHSPRMAQRRIAMAKYLG 819
Query: 663 ELYNTSFLKFEVLLDTMYRILRFGYPSGQPNPFFINEGDLPDNYFRISLISTIL--LGIN 720
E+YN ++ +L+T+Y I+ G + Q ++ D PD+ FR+ L +L
Sbjct: 820 EMYNYKLVESTNILNTLYSIISLGVSNDQN---VVSPLDPPDSLFRLKLACMLLDTCAPY 876
Query: 721 RKSEFALKKLKIFIQFFE-YYIFCKDQPLPNEVSFKVENVFALYP---DHS 767
S+ KKL F+ FF+ YY F K P V K EN L+P DH+
Sbjct: 877 FTSQATRKKLDYFLVFFQHYYWFKKSHP----VFSKTENTSDLFPILMDHT 923
Score = 77.4 bits (189), Expect = 1e-13
Identities = 95/376 (25%), Positives = 155/376 (40%), Gaps = 58/376 (15%)
Query: 15 KLDSSIKRNTGFIKKLKQGIAKESKTGLLNDIREVSLEKYLSEIITTTNEALFKNSGKGD 74
KLDS++K+NT F+KKLK A + GLL +I ++L KY+SEI EA K +
Sbjct: 99 KLDSNLKKNTAFVKKLKLFTATQ-LDGLLREISALNLSKYISEICAALVEAKLKMT---- 153
Query: 75 DIVAVVEIVSGLHQRFNMDFTLPLIESFLFIFETSSDEAETEKDKTTRTNVLKACTRVLI 134
D+ AVV + S LH + DF + +E++ + E K + L+ R+
Sbjct: 154 DVPAVVTLASRLHCTY-ADFDVHFLEAWQKALNIKATE------KIGNPSKLRVDLRLFA 206
Query: 135 ELHLTGVLPSLDDLNKSKLPPFVVKRYSKKEPIVFIVLREVLNYKFKEALTTPVAILILK 194
EL +GV+ L + + + K + F ++ + +E A L+ +
Sbjct: 207 ELVSSGVIQMKPGLAQLGVVLVHLIALDKDDHSNFSIILSFCRHCGEE-----YAGLVPQ 261
Query: 195 KYPELLSE---EVSDMDNLINSEE--LKTLLRSLFKIYKDIVFQQTVELNKKTIKLMKEH 249
K +L ++ EV D L ++ L+T+L+ FK V + EL + + K
Sbjct: 262 KMQQLATKYGVEVPKSDFLTADKQLNLRTMLKGYFKALCKHVLAEQAEL----MNMTKNI 317
Query: 250 HKAQIRTGKESSEYLDDFNELNPIFEKFSTVATALAEAFNVDPPELLD----------IE 299
+ G+ S+E + + F+K A +L+E PEL I+
Sbjct: 318 RRTMECKGEISTEKREKCELMQAGFDKLLASAQSLSELLGEPLPELAKESEGCNPGTVID 377
Query: 300 QSLKEQEPSIITPASDWKEKQEPIWENEENRRFYENLADLSAAYATYDPEKTPSPEDVIA 359
L ++ P W +EE R FY +L DL + K
Sbjct: 378 NMLDSASFGVLDP-----------WGDEETRAFYTDLPDLRQFLPNFSAPK--------- 417
Query: 360 LFADFETVETKDEIDE 375
D ET+E E+ E
Sbjct: 418 --VDLETLEEPSELTE 431
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.135 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,055,943
Number of Sequences: 60738
Number of extensions: 2320542
Number of successful extensions: 8029
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 7982
Number of HSP's gapped (non-prelim): 20
length of query: 1081
length of database: 30,389,216
effective HSP length: 117
effective length of query: 964
effective length of database: 23,282,870
effective search space: 22444686680
effective search space used: 22444686680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)