ORF      STATUS       Function Best COG  Functional category                                          Pathways and functional systems
r_klactIV3466   good          T     KOG4039  Signal transduction mechanisms                                 Serine/threonine kinase TIP30/CC3

BLASTP 2.2.3 [May-13-2002]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= r_klactIV3466 1181157 1180486 -224 
         (224 letters)

Database: KOG eukaryal database 04/03 
           60,738 sequences; 30,389,216 total letters

Searching..................................................done

Color Key for Alignment Scores:   


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

YER004w [T] KOG4039 Serine/threonine kinase TIP30/CC3                 202   4e-52
CE27103 [T] KOG4039 Serine/threonine kinase TIP30/CC3                  80   3e-15
Hs20127503 [T] KOG4039 Serine/threonine kinase TIP30/CC3               58   1e-08

>YER004w [T] KOG4039 Serine/threonine kinase TIP30/CC3
          Length = 231

 Score =  202 bits (513), Expect = 4e-52
 Identities = 110/224 (49%), Positives = 141/224 (62%), Gaps = 4/224 (1%)

Query: 1   MNALVLGATGLCGSSFLKYASQNSGFDKVYAITRRDLPSELKTDXXXXXXXXETNKWGEL 60
           MN LVLGATGLCG  FL++A +   F KVYAI RR+LP    TD        + +KW +L
Sbjct: 1   MNGLVLGATGLCGGGFLRHAQEAPQFSKVYAILRRELPFPA-TDKVVAIVERDNSKWSQL 59

Query: 61  IPEDXX--XXXXXXXXXXXXXXXFENQYKIDHDMNVELAKVAKAKGYKVCVLVSSLGANE 118
           I  +                    + QYKIDHD+N++LA+ AK KG +  VLVSS GA+ 
Sbjct: 60  ITNEMNPQVLFTALATTRAAAGGLDKQYKIDHDLNLQLAQAAKEKGCETIVLVSSAGAHP 119

Query: 119 NSFLPYLKLKGETERDIIALDFDKTIILRPGGLLGER-NGTFKGFGDKYFSKISSCFYRS 177
           +S   Y+K+KGE ERD+IALDF   IILRPG LLGER N    GFG    + + +  YRS
Sbjct: 120 DSRFGYMKMKGEIERDVIALDFKHIIILRPGPLLGERTNSKQSGFGGNLTAALGTRVYRS 179

Query: 178 KLQSALGYPIYGDEVGKVGVKLALDSSRTEKVQIVSSPELLKLA 221
           + Q  LGYP+YGDEVGKVGV LAL++S  +KVQ VSS ++L ++
Sbjct: 180 RFQRLLGYPVYGDEVGKVGVHLALNTSGKDKVQFVSSKDILDIS 223


>CE27103 [T] KOG4039 Serine/threonine kinase TIP30/CC3
          Length = 458

 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 52/155 (33%), Positives = 79/155 (50%), Gaps = 3/155 (1%)

Query: 2   NALVLGATGLCGSSFLKYASQNSGFDKVYAITRRDLPSELKTDXXXXXXXXETNKWGELI 61
           +A V+GATG  GS  +K  ++++ F KV  + RR  P +  T         + +K  E  
Sbjct: 243 SAFVVGATGAVGSELVKLLAESTKFSKVVVLARR--PVDGATGDKLIQKTVDFDKLEENA 300

Query: 62  PE-DXXXXXXXXXXXXXXXXXFENQYKIDHDMNVELAKVAKAKGYKVCVLVSSLGANENS 120
            +                    +  YK+DHD  +  AK+AK  G K  VLVSS+GA+ +S
Sbjct: 301 EDIQGVDVAFCALGTTRGKSGADGFYKVDHDYVMSAAKMAKENGVKQFVLVSSVGADASS 360

Query: 121 FLPYLKLKGETERDIIALDFDKTIILRPGGLLGER 155
              Y K KGE E++I  L+F+K +I+RPG +  +R
Sbjct: 361 RFLYPKTKGEVEKEIGELNFEKFVIMRPGLIEAKR 395


>Hs20127503 [T] KOG4039 Serine/threonine kinase TIP30/CC3
          Length = 242

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 46/161 (28%), Positives = 71/161 (43%), Gaps = 1/161 (0%)

Query: 2   NALVLGATGLCGSSFLKYASQNSGFDKVYAITRRDLPSELKTDXXXXXXXXETNKWGELI 61
           +  +LGA+G  G   LK   +   F KV  I RR L  + +          +  K  +  
Sbjct: 20  SVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYA 79

Query: 62  PE-DXXXXXXXXXXXXXXXXXFENQYKIDHDMNVELAKVAKAKGYKVCVLVSSLGANENS 120
                                 E   ++D D  ++ A++AKA G K   L+SS GA+++S
Sbjct: 80  SAFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSS 139

Query: 121 FLPYLKLKGETERDIIALDFDKTIILRPGGLLGERNGTFKG 161
              YL++KGE E  +  L FD+  + RPG LL +R  +  G
Sbjct: 140 NFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPG 180


  Database: KOG eukaryal database 04/03
    Posted date:  Apr 14, 2003  1:07 PM
  Number of letters in database: 30,389,216
  Number of sequences in database:  60,738
  
Lambda     K      H
   0.315    0.137    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,597,730
Number of Sequences: 60738
Number of extensions: 443663
Number of successful extensions: 586
Number of sequences better than 1.0e-05: 3
Number of HSP's better than  0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 579
Number of HSP's gapped (non-prelim): 4
length of query: 224
length of database: 30,389,216
effective HSP length: 102
effective length of query: 122
effective length of database: 24,193,940
effective search space: 2951660680
effective search space used: 2951660680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)