ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV3587 good U KOG0937 Intracellular trafficking, secretion, and vesicular transport Adaptor complexes medium subunit family
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV3587 1216574 1217902 443
(443 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL259c [U] KOG0937 Adaptor complexes medium subunit family 645 0.0
SPBP16F5.07 [U] KOG0937 Adaptor complexes medium subunit family 461 e-130
Hs14210504 [U] KOG0937 Adaptor complexes medium subunit family 456 e-128
Hs9506797 [U] KOG0937 Adaptor complexes medium subunit family 450 e-126
CE28050 [U] KOG0937 Adaptor complexes medium subunit family 435 e-122
7299202 [U] KOG0937 Adaptor complexes medium subunit family 433 e-121
At1g60780 [U] KOG0937 Adaptor complexes medium subunit family 411 e-114
CE11129 [U] KOG0937 Adaptor complexes medium subunit family 402 e-112
At1g10730 [U] KOG0937 Adaptor complexes medium subunit family 393 e-109
At5g46630 [U] KOG0938 Adaptor complexes medium subunit family 295 9e-80
Hs14917109 [U] KOG0938 Adaptor complexes medium subunit family 290 2e-78
CE28642 [U] KOG0938 Adaptor complexes medium subunit family 287 3e-77
7300861 [U] KOG0938 Adaptor complexes medium subunit family 270 2e-72
SPAC31A2.09c [U] KOG0938 Adaptor complexes medium subunit family 236 5e-62
At4g24550 [U] KOG0937 Adaptor complexes medium subunit family 210 3e-54
YOL062c [U] KOG0938 Adaptor complexes medium subunit family 178 1e-44
Hs14917111 [U] KOG0937 Adaptor complexes medium subunit family 171 2e-42
Hs6912240 [U] KOG2740 Clathrin-associated protein medium chain 157 3e-38
Hs5803000 [U] KOG2740 Clathrin-associated protein medium chain 152 1e-36
7290785 [U] KOG2740 Clathrin-associated protein medium chain 147 2e-35
CE04654 [U] KOG2740 Clathrin-associated protein medium chain 145 1e-34
At1g56590 [U] KOG2740 Clathrin-associated protein medium chain 134 4e-31
YHL019c [U] KOG0937 Adaptor complexes medium subunit family 120 4e-27
Hs17461156 [U] KOG0937 Adaptor complexes medium subunit family 107 4e-23
SPBC651.11c [U] KOG2740 Clathrin-associated protein medium chain 86 9e-17
HsM14916441 [U] KOG2677 Stoned B synaptic vesicle biogenesis pro... 65 2e-10
Hs21361863 [U] KOG2677 Stoned B synaptic vesicle biogenesis protein 65 2e-10
Hs5803153_1 [U] KOG2677 Stoned B synaptic vesicle biogenesis pro... 55 2e-07
CE08425 [U] KOG2677 Stoned B synaptic vesicle biogenesis protein 54 5e-07
7288911 [U] KOG2677 Stoned B synaptic vesicle biogenesis protein 51 4e-06
>YPL259c [U] KOG0937 Adaptor complexes medium subunit family
Length = 475
Score = 645 bits (1663), Expect = 0.0
Identities = 320/474 (67%), Positives = 378/474 (79%), Gaps = 31/474 (6%)
Query: 1 MASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYV 60
MAS V FCD GKPLLSRRY+DD+ SA++ F LL + E++S+++PPC +HNG+ Y+++
Sbjct: 1 MASAVYFCDHNGKPLLSRRYRDDIPLSAIDKFPILLSDLEEQSNLIPPCLNHNGLEYLFI 60
Query: 61 QYNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMD 120
Q+ND+YV+A+ S+S NA +F F++KL+ SIRDN++IIYELLDE+MD
Sbjct: 61 QHNDLYVVAIVTSLSANAAAIFTFLHKLVEVLSDYLKTVEEESIRDNFVIIYELLDEVMD 120
Query: 121 KGVPQVTETKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFL 180
G+PQ+TETKMLKQYITQKSFKL +SAKK++N RPP LTNSVSWRPEGI +KKNEAFL
Sbjct: 121 YGIPQITETKMLKQYITQKSFKLVKSAKKKRNATRPPVALTNSVSWRPEGITHKKNEAFL 180
Query: 181 DVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIF------------- 227
D++ESINMLMTQ+GQVLRSEI+G VKV S+LSGMPDLKLG+NDKGIF
Sbjct: 181 DIVESINMLMTQKGQVLRSEIIGDVKVNSKLSGMPDLKLGINDKGIFSKYLDDDTNIPSA 240
Query: 228 ----TTNDQEDSPEPVVSS----KKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGE 279
+ N+ E +P ++S KK NIELEDLKFHQCVRLSKFENEKIITFIPPDG+
Sbjct: 241 SATTSDNNTETDKKPSITSSSATNKKKVNIELEDLKFHQCVRLSKFENEKIITFIPPDGK 300
Query: 280 FDLMTYRLSTPIKPLIWCDVKVQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDAD 339
FDLM YRLST IKPLIWCDV VQVHS SRIEIHC+AKAQIK+KS A NVEILIP+P+DAD
Sbjct: 301 FDLMNYRLSTTIKPLIWCDVNVQVHSNSRIEIHCKAKAQIKRKSTATNVEILIPVPDDAD 360
Query: 340 SPTFKYSRGNIKWVPEKNAILWKFSSFQGGKEYSMAAQLGLPSVSDAEP-----PK---- 390
+PTFKYS G++K+VPEK+AILWK SF GGKEYSM+A+LGLPS+S+ E PK
Sbjct: 361 TPTFKYSHGSLKYVPEKSAILWKIRSFPGGKEYSMSAELGLPSISNNEDGNRTMPKSNAE 420
Query: 391 -LKRPVQIKFQIPYFTTSGIQVRYLKIEEPKLQYNSYPWVRYITQSGDDYTIRL 443
LK PVQIKFQIPYFTTSGIQVRYLKI EPKLQY SYPWVRYITQSGDDYTIRL
Sbjct: 421 ILKGPVQIKFQIPYFTTSGIQVRYLKINEPKLQYKSYPWVRYITQSGDDYTIRL 474
>SPBP16F5.07 [U] KOG0937 Adaptor complexes medium subunit family
Length = 426
Score = 461 bits (1187), Expect = e-130
Identities = 229/443 (51%), Positives = 314/443 (70%), Gaps = 19/443 (4%)
Query: 1 MASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYV 60
MAS + + KGK ++SR Y+ D+ S VE F L E E+E PC H GI+Y+Y+
Sbjct: 1 MASAIFVLNLKGKVIISRDYRADIPMSVVEKFLPLKSEVEEEQGFSTPCLTHEGINYIYI 60
Query: 61 QYNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMD 120
+NDVY+LAL++ S +A M F+ K+ + SIRDN++++YELLDE+MD
Sbjct: 61 HHNDVYLLALSKMNS-DAMEMLVFLRKMADVFIDYFKELQEESIRDNFVLVYELLDEIMD 119
Query: 121 KGVPQVTETKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFL 180
G PQ TETK+L++YITQ S + KK A PP +TN++SWR EGI Y+KNE FL
Sbjct: 120 FGFPQTTETKILQEYITQTS----NTVKKH---APPPIAMTNAISWRSEGIHYRKNEVFL 172
Query: 181 DVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVV 240
DVIES+N++ G V++SEILG V+++ LSGMP+L+LGLNDK +F
Sbjct: 173 DVIESVNLIAAADGTVIQSEILGKVRLKCYLSGMPELRLGLNDKVLFEA----------A 222
Query: 241 SSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVK 300
K + +E+ED+KFHQCVRL++FEN++ I+FIPPDGEFDLM+YR+S+ ++PLIW + +
Sbjct: 223 GRTIKGNTVEMEDVKFHQCVRLARFENDRTISFIPPDGEFDLMSYRMSSNVRPLIWVECE 282
Query: 301 VQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAIL 360
VHSGSRIE +AKAQ KK+ +ANNV+I+IP+PEDADSP F+ S G++++ PE+ A++
Sbjct: 283 SIVHSGSRIEFMVKAKAQFKKRCIANNVQIIIPVPEDADSPRFQTSNGHVQYAPEQAAMV 342
Query: 361 WKFSSFQGGKEYSMAAQLGLPSVSDAE-PPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEP 419
W F GGKE+ M A++GLPSV + + + KRPVQ+KF IPYFTTSGIQVRYLKI EP
Sbjct: 343 WNIKKFAGGKEFFMRAEMGLPSVKNEDIQVQKKRPVQLKFAIPYFTTSGIQVRYLKITEP 402
Query: 420 KLQYNSYPWVRYITQSGDDYTIR 442
KL Y++ PWVRY+TQ+G +Y+IR
Sbjct: 403 KLNYHAMPWVRYVTQNGTEYSIR 425
>Hs14210504 [U] KOG0937 Adaptor complexes medium subunit family
Length = 423
Score = 456 bits (1174), Expect = e-128
Identities = 231/441 (52%), Positives = 316/441 (71%), Gaps = 22/441 (4%)
Query: 2 ASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQ 61
AS V D KGK L+ R Y+ DV S VE F +L+E+E+E ++ P H G+ +M+++
Sbjct: 3 ASAVYVLDLKGKVLICRNYRGDVDMSEVEHFMPILMEKEEEG-MLSPILAHGGVRFMWIK 61
Query: 62 YNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDK 121
+N++Y++A ++ + + +F+F+YK++ SIRDN++IIYELLDE+MD
Sbjct: 62 HNNLYLVATSKK-NACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDF 120
Query: 122 GVPQVTETKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLD 181
G PQ T++K+L++YITQ+ KL A RPP +TN+VSWR EGIKY+KNE FLD
Sbjct: 121 GYPQTTDSKILQEYITQEGHKLETGAP------RPPATVTNAVSWRSEGIKYRKNEVFLD 174
Query: 182 VIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVS 241
VIES+N+L++ G VLRSEI+G++K+R LSGMP+L+LGLNDK +F +
Sbjct: 175 VIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDN-----------T 223
Query: 242 SKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKV 301
+ K+ ++ELED+KFHQCVRLS+FEN++ I+FIPPDGEF+LM+YRL+T +KPLIW + +
Sbjct: 224 GRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVI 283
Query: 302 QVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILW 361
+ HS SRIE +AK+Q K++S ANNVEI IP+P DADSP FK + G++KWVPE + I+W
Sbjct: 284 EKHSHSRIEYMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVW 343
Query: 362 KFSSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPKL 421
SF GGKEY M A GLPSV +AE + K P+ +KF+IPYFTTSGIQVRYLKI E K
Sbjct: 344 SIKSFPGGKEYLMRAHFGLPSV-EAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIE-KS 401
Query: 422 QYNSYPWVRYITQSGDDYTIR 442
Y + PWVRYITQ+G DY +R
Sbjct: 402 GYQALPWVRYITQNG-DYQLR 421
>Hs9506797 [U] KOG0937 Adaptor complexes medium subunit family
Length = 423
Score = 450 bits (1158), Expect = e-126
Identities = 227/441 (51%), Positives = 317/441 (71%), Gaps = 22/441 (4%)
Query: 2 ASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQ 61
AS V D KGKPL+SR Y+ DV+ S +E F LL++RE+E + + P H +H+++++
Sbjct: 3 ASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGA-LAPLLSHGQVHFLWIK 61
Query: 62 YNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDK 121
++++Y++A T S + NA+ +++F+YK I SIRDN++I+YELLDE+MD
Sbjct: 62 HSNLYLVATT-SKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF 120
Query: 122 GVPQVTETKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLD 181
G PQ T++K+L++YITQ+S KL + +R P +TN+VSWR EGIKYKKNE F+D
Sbjct: 121 GFPQTTDSKILQEYITQQSNKL------ETGKSRVPPTVTNAVSWRSEGIKYKKNEVFID 174
Query: 182 VIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVS 241
VIES+N+L+ G VL SEI+GT+K++ LSGMP+L+LGLND+ +F ++
Sbjct: 175 VIESVNLLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFE-----------LT 223
Query: 242 SKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKV 301
+ KN ++ELED+KFHQCVRLS+F+N++ I+FIPPDG+F+LM+YRLST +KPLIW + +
Sbjct: 224 GRSKNKSVELEDVKFHQCVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVI 283
Query: 302 QVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILW 361
+ S SR+EI +AK Q KK+SVAN VEI +P+P DADSP FK S G+ K+VPE+N ++W
Sbjct: 284 EKFSHSRVEIMVKAKGQFKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIW 343
Query: 362 KFSSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPKL 421
SF GGKEY M A GLPSV + E + + P+ +KF+IPYFT SGIQVRY+KI E K
Sbjct: 344 SIKSFPGGKEYLMRAHFGLPSV-EKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIE-KS 401
Query: 422 QYNSYPWVRYITQSGDDYTIR 442
Y + PWVRYITQSG DY +R
Sbjct: 402 GYQALPWVRYITQSG-DYQLR 421
>CE28050 [U] KOG0937 Adaptor complexes medium subunit family
Length = 422
Score = 435 bits (1119), Expect = e-122
Identities = 215/435 (49%), Positives = 312/435 (71%), Gaps = 23/435 (5%)
Query: 9 DSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQYNDVYVL 68
D KGK ++SR Y+ D+ +A++ F HLL+E+E+E S P + + +++++++ ++Y++
Sbjct: 10 DLKGKTIISRNYRGDIDMTAIDKFIHLLMEKEEEGSAAPVLTYQD-TNFVFIKHTNIYLV 68
Query: 69 ALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDKGVPQVTE 128
+ RS +VN T + +F+YK + S+RDN+++IYELLDEMMD G PQ TE
Sbjct: 69 SACRS-NVNVTMILSFLYKCVEVFSEYFKDVEEESVRDNFVVIYELLDEMMDFGFPQTTE 127
Query: 129 TKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLDVIESINM 188
+++L++YITQ+ KL + RPP +TN+VSWR EGIKY+KNE FLDVIES+NM
Sbjct: 128 SRILQEYITQEGQKLI-------SAPRPPMAVTNAVSWRSEGIKYRKNEVFLDVIESVNM 180
Query: 189 LMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVSSKKKNSN 248
L + G VL+SEI+G+VK+R L+GMP+L+LGLNDK +F S + K+ +
Sbjct: 181 LASANGTVLQSEIVGSVKMRVYLTGMPELRLGLNDKVLFEG-----------SGRGKSKS 229
Query: 249 IELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKVQVHSGSR 308
+ELED+KFHQCVRLS+F+ ++ I+FIPPDG F+LM+YRL+T +KPLIW + ++ HS SR
Sbjct: 230 VELEDVKFHQCVRLSRFDTDRTISFIPPDGAFELMSYRLTTVVKPLIWIETSIERHSHSR 289
Query: 309 IEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILWKFSSFQG 368
+ +AK+Q K++S ANNVEI+IP+P DADSP FK S G++K+ PE++A +W +F G
Sbjct: 290 VSFIIKAKSQFKRRSTANNVEIIIPVPSDADSPKFKTSIGSVKYTPEQSAFVWTIKNFPG 349
Query: 369 GKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPKLQYNSYPW 428
GKEY + A L LPSV +E + + P+++KF+IPYFTTSGIQVRYLKI E K Y + PW
Sbjct: 350 GKEYLLTAHLSLPSVM-SEESEGRPPIKVKFEIPYFTTSGIQVRYLKIIE-KSGYQALPW 407
Query: 429 VRYITQSGDDYTIRL 443
VRYITQ+G +Y +R+
Sbjct: 408 VRYITQNG-EYEMRM 421
>7299202 [U] KOG0937 Adaptor complexes medium subunit family
Length = 426
Score = 433 bits (1114), Expect = e-121
Identities = 221/443 (49%), Positives = 309/443 (68%), Gaps = 23/443 (5%)
Query: 2 ASYVAFCDSKGKPLLSRRYQ-DDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYV 60
+S + D KGK L+SR Y+ D++ + ++ F LL+ERE+E ++ P + Y+
Sbjct: 3 SSAIFVLDVKGKVLISRNYRGDNIDMAVIDKFMPLLMEREEEG-LITPILQTAETTFAYI 61
Query: 61 QYNDVYVLALT-RSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMM 119
+ N++Y+++ T R+ +VN +F F++K+ SIRDN++IIYELLDE++
Sbjct: 62 KTNNLYIVSTTPRNKNVNIALVFVFLHKIAQVFVEYFKELEEESIRDNFVIIYELLDELL 121
Query: 120 DKGVPQVTETKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAF 179
D G PQ T++K+L++YITQ+ KL R P +TN+VSWR EGIKY+KNE F
Sbjct: 122 DFGYPQTTDSKILQEYITQEGHKLELQP-------RIPVAVTNAVSWRSEGIKYRKNEVF 174
Query: 180 LDVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPV 239
LDVIES+N+L G VLRSEI+G +K+R LSGMP+L+LGLNDK +F +
Sbjct: 175 LDVIESVNLLANANGNVLRSEIVGAIKMRVYLSGMPELRLGLNDKVLFES---------- 224
Query: 240 VSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDV 299
+ + K+ ++ELED+KFHQCVRLS+FEN++ I+FIPPDGEF+LM+YRL+T +KPLIW +
Sbjct: 225 -TGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIES 283
Query: 300 KVQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAI 359
++ H+ SR+E +AK+Q K++S ANNVEI+IP+P DADSP FK + G+ K+ PE+NAI
Sbjct: 284 VIERHAHSRVEYMIKAKSQFKRRSTANNVEIVIPVPADADSPKFKTTIGSCKYAPEQNAI 343
Query: 360 LWKFSSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEP 419
+W SF GGKEY M A GLPSV + + K P+Q++F+IPYFTTSGIQVRYLKI E
Sbjct: 344 IWTIKSFPGGKEYLMRAHFGLPSVESEDNTEGKPPIQVRFEIPYFTTSGIQVRYLKIIE- 402
Query: 420 KLQYNSYPWVRYITQSGDDYTIR 442
K Y + PWVRYITQ+G DY +R
Sbjct: 403 KSGYQALPWVRYITQNG-DYQLR 424
>At1g60780 [U] KOG0937 Adaptor complexes medium subunit family
Length = 428
Score = 411 bits (1056), Expect = e-114
Identities = 203/443 (45%), Positives = 304/443 (67%), Gaps = 21/443 (4%)
Query: 2 ASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQ 61
AS + D KG+ L+ R Y+ DVS + E F L+E+E +S P + NG+ YM+VQ
Sbjct: 5 ASALFLLDIKGRVLVWRDYRGDVSAAQAERFFTKLIEKEGDSQSNDPVAYDNGVTYMFVQ 64
Query: 62 YNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDK 121
+++VY++ +R + NA ++ F++++++ S+RDN++++YELLDEMMD
Sbjct: 65 HSNVYLMIASRQ-NCNAASLLFFLHRVVDVFKHYFEELEEESLRDNFVVVYELLDEMMDF 123
Query: 122 GVPQVTETKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLD 181
G PQ TE ++L ++I ++++ + RPP +TN+VSWR EGI+YKKNE FLD
Sbjct: 124 GYPQYTEARILSEFIKTDAYRM-------EVTQRPPMAVTNAVSWRSEGIQYKKNEVFLD 176
Query: 182 VIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVS 241
VIE++N+L+ GQ++RS+++G +K+R+ L+GMP+ KLGLND+ + +
Sbjct: 177 VIENVNILVNSNGQIVRSDVVGALKMRTYLTGMPECKLGLNDRVLLEAQGRAT------- 229
Query: 242 SKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKV 301
K I+LED+KFHQCVRL++FEN++ I+FIPPDG FDLMTYRLST +KPLIW + ++
Sbjct: 230 ---KGKAIDLEDIKFHQCVRLARFENDRTISFIPPDGAFDLMTYRLSTQVKPLIWVEAQI 286
Query: 302 QVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILW 361
+ HS SR+E+ +A++Q K++S A NVEI +P+P DA +PT + S G+ + PEK+A++W
Sbjct: 287 ESHSRSRVEMLIKARSQFKERSTATNVEIELPVPTDASNPTVRTSLGSASYAPEKDALVW 346
Query: 362 KFSSFQGGKEYSMAAQLGLPSVSDAE-PPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPK 420
K SF G KEY + A+ LPS++ E P+ K P+++KF+IPYFT SGIQVRYLKI E K
Sbjct: 347 KIKSFPGNKEYMLRAEFHLPSITAEEATPERKAPIRVKFEIPYFTVSGIQVRYLKIIE-K 405
Query: 421 LQYNSYPWVRYITQSGDDYTIRL 443
Y + PWVRYIT +G +Y +RL
Sbjct: 406 SGYQALPWVRYITMAG-EYELRL 427
>CE11129 [U] KOG0937 Adaptor complexes medium subunit family
Length = 470
Score = 402 bits (1033), Expect = e-112
Identities = 214/481 (44%), Positives = 301/481 (62%), Gaps = 67/481 (13%)
Query: 9 DSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQYNDVYVL 68
D KG ++SR Y+ DV S +E F LL+E+E E S P H GI Y Y++Y +VY++
Sbjct: 10 DLKGNVVISRNYRGDVDMSCIEKFMPLLVEKEDEGSASPVLVHQ-GISYTYIKYMNVYLV 68
Query: 69 ALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDKGVPQVTE 128
+++ + N + + +YK++ ++RDN++IIYEL DEM+D G PQ TE
Sbjct: 69 TISKK-NTNVILVLSALYKIVEVFCEYFKTLEEEAVRDNFVIIYELFDEMLDFGYPQTTE 127
Query: 129 TKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLDVIESINM 188
+K+L+++ITQ+ +L RPP +TN+VSWR EGIKY+KNE FLDVIES+NM
Sbjct: 128 SKILQEFITQQGNRL--------ETVRPPMAVTNAVSWRSEGIKYRKNEVFLDVIESVNM 179
Query: 189 LMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVSSKKKNSN 248
L QG VLRSEI+G+++ R LSGMP+L+LGLNDK F + SS++ NS
Sbjct: 180 LANAQGTVLRSEIVGSIRFRVVLSGMPELRLGLNDKVFFQQSG--------ASSRRGNSG 231
Query: 249 --IELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKVQVHSG 306
+ELED+KFHQCVRLS+F++E+ I+FIPPDGEF+LM+YRL+T +KPLIW + V+ H+
Sbjct: 232 KGVELEDIKFHQCVRLSRFDSERTISFIPPDGEFELMSYRLTTQVKPLIWVEAAVERHAH 291
Query: 307 SRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILWKFSSF 366
SR+E +AK+Q K++SVAN+VE++IP+P D +P FK G K+VPE NAI+W SF
Sbjct: 292 SRVEYMVKAKSQFKRQSVANHVEVIIPVPSDVSAPKFKTGAGTAKYVPELNAIVWSIRSF 351
Query: 367 Q--------------------------------------------GGKEYSMAAQLGLPS 382
GG+EY M + LPS
Sbjct: 352 PGEHQVRNIFKYQLNRNVMHICWKTVQYRKKILSEIFFFYIIFTFGGREYIMRSSFMLPS 411
Query: 383 VSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPKLQYNSYPWVRYITQSGDDYTIR 442
+ +E + + P+ +KF+IPY+TTSG+QVRYLKI E K Y + PWVRY+TQ+G DY +R
Sbjct: 412 IG-SEELEGRPPINVKFEIPYYTTSGLQVRYLKIIE-KSGYQALPWVRYVTQNG-DYQMR 468
Query: 443 L 443
+
Sbjct: 469 M 469
>At1g10730 [U] KOG0937 Adaptor complexes medium subunit family
Length = 428
Score = 393 bits (1010), Expect = e-109
Identities = 197/443 (44%), Positives = 298/443 (66%), Gaps = 21/443 (4%)
Query: 2 ASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQ 61
AS + D KG+ L+ R Y+ DV+ + E F L+E E +S P + NG+ YM+VQ
Sbjct: 5 ASALFLLDIKGRVLVWRDYRGDVTAAQAERFFTKLIETEGDSQSNDPVAYDNGVTYMFVQ 64
Query: 62 YNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDK 121
++++Y++ +R + NA ++ F++++++ S+RDN++++YELLDEMMD
Sbjct: 65 HSNIYLMIASRQ-NCNAASLLFFLHRVVDVFKHYFEELEEESLRDNFVVVYELLDEMMDF 123
Query: 122 GVPQVTETKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLD 181
G PQ TE ++L ++I ++++ + RPP +TNSVSWR EG+K+KKNE FLD
Sbjct: 124 GYPQFTEARILSEFIKTDAYRM-------EVTQRPPMAVTNSVSWRSEGLKFKKNEVFLD 176
Query: 182 VIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVS 241
VIES+N+L+ GQ++RS+++G +K+R+ LSGMP+ KLGLND+ + +
Sbjct: 177 VIESVNILVNSNGQIVRSDVVGALKMRTYLSGMPECKLGLNDRILLEAQGRAI------- 229
Query: 242 SKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKV 301
K I+LED+KFHQCVRL++FEN++ I+FIPPDG FDLMTYRLST +KPLIW + +
Sbjct: 230 ---KGKAIDLEDIKFHQCVRLARFENDRTISFIPPDGSFDLMTYRLSTQVKPLIWVEAHI 286
Query: 302 QVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILW 361
+ HS SR+E+ +A++Q K +S A +VEI +P+P DA +P + S G+ + PEK+A++W
Sbjct: 287 ERHSRSRVEMLVKARSQFKDRSYATSVEIELPVPTDAYNPDVRTSLGSAAYAPEKDALVW 346
Query: 362 KFSSFQGGKEYSMAAQLGLPSVSDAE-PPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPK 420
K F G KE+++ A LPS++ E P+ K P+++KF+IP F SGIQVRYLKI E K
Sbjct: 347 KIQYFYGNKEHTLKADFHLPSIAAEEATPERKAPIRVKFEIPKFIVSGIQVRYLKIIE-K 405
Query: 421 LQYNSYPWVRYITQSGDDYTIRL 443
Y ++PWVRYIT +G +Y +RL
Sbjct: 406 SGYQAHPWVRYITMAG-EYELRL 427
>At5g46630 [U] KOG0938 Adaptor complexes medium subunit family
Length = 438
Score = 295 bits (755), Expect = 9e-80
Identities = 163/443 (36%), Positives = 265/443 (59%), Gaps = 12/443 (2%)
Query: 2 ASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQ 61
AS + F + +G L++R Y+DDV + V++F+ +++ ++ + P G ++Y++
Sbjct: 5 ASAIYFLNLRGDVLINRTYRDDVGGNMVDAFRTHIMQTKELGNC--PVRQIGGCSFVYMR 62
Query: 62 YNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXX-SIRDNYIIIYELLDEMMD 120
++VY++ + S + N F F+ + + +IR+N+++IYELLDE+MD
Sbjct: 63 ISNVYIVIVVSS-NANVACGFKFVVEAVALFKSYFGGAFDEDAIRNNFVLIYELLDEIMD 121
Query: 121 KGVPQVTETKMLKQYITQKSFKLTRSAK-KQKNVARPPTELTNSVSWRPEGIKYKKNEAF 179
G PQ ++LK YITQ+ + S+K K K V ++T +V WR EG+ YKKNE F
Sbjct: 122 FGYPQNLSPEILKLYITQEGVRSPFSSKPKDKPVPNATLQVTGAVGWRREGLAYKKNEVF 181
Query: 180 LDVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPV 239
LD++ES+N+LM+ +G VLR ++ G V ++ LSGMPDLKLGLNDK I + E P
Sbjct: 182 LDIVESVNLLMSSKGNVLRCDVTGKVLMKCFLSGMPDLKLGLNDK-IGLEKESEMKSRPA 240
Query: 240 VSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDV 299
S K IEL+D+ FHQCV L++F +EK ++F+PPDGEF+LM YR++ +
Sbjct: 241 KSGK----TIELDDVTFHQCVNLTRFNSEKTVSFVPPDGEFELMKYRITEGVNLPFRVLP 296
Query: 300 KVQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAI 359
++ +R+E++ + K+ K A V + IP+P+ F+ + G K+ P + +
Sbjct: 297 TIKELGRTRMEVNVKVKSVFGAKMFALGVVVKIPVPKQTAKTNFQVTTGRAKYNPSIDCL 356
Query: 360 LWKFSSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEP 419
+WK F G E +++A++ L S + + P+Q++FQ+P FT SG++VR+LK+ E
Sbjct: 357 VWKIRKFPGQTESTLSAEIELISTMGEKKSWTRPPIQMEFQVPMFTASGLRVRFLKVWE- 415
Query: 420 KLQYNSYPWVRYITQSGDDYTIR 442
K YN+ WVRYIT++G Y IR
Sbjct: 416 KSGYNTVEWVRYITKAG-SYEIR 437
>Hs14917109 [U] KOG0938 Adaptor complexes medium subunit family
Length = 435
Score = 290 bits (743), Expect = 2e-78
Identities = 158/429 (36%), Positives = 262/429 (60%), Gaps = 13/429 (3%)
Query: 11 KGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQYNDVYVLAL 70
KG+ L+SR Y+DD+ ++AV++F+ ++ Q+ V P + + +V+ +++++ A+
Sbjct: 11 KGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ--VRSPVTNIARTSFFHVKRSNIWLAAV 68
Query: 71 TRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDKGVPQVTETK 130
T+ +VNA +F F+YK+ + +I++N+++IYELLDE++D G PQ +ET
Sbjct: 69 TKQ-NVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFGYPQNSETG 127
Query: 131 MLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLDVIESINMLM 190
LK +ITQ+ K K++++ + +++T + WR EGIKY++NE FLDV+ES+N+LM
Sbjct: 128 ALKTFITQQGIKSQHQTKEEQS--QITSQVTGQIGWRREGIKYRRNELFLDVLESVNLLM 185
Query: 191 TQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVSSKKKNSNIE 250
+ QGQVL + + G V ++S LSGMP+ K G+NDK + + + E +SK +I
Sbjct: 186 SPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADE---TSKSGKQSIA 242
Query: 251 LEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKVQVHSGSRIE 310
++D FHQCVRLSKF++E+ I+FIPPDGEF+LM YR + I V+ +++E
Sbjct: 243 IDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLE 302
Query: 311 IHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILWKFSSFQGGK 370
+ K+ K +A +E+ IP P + +G K+ +NAI+WK G K
Sbjct: 303 VKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMK 362
Query: 371 EYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPKLQYNSY---P 427
E ++A++ L +D + + P+ + F++P F SG++VRYLK+ EPKL Y+ +
Sbjct: 363 ESQISAEIELLPTND-KKKWARPPISMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHDVIK 420
Query: 428 WVRYITQSG 436
WVRYI +SG
Sbjct: 421 WVRYIGRSG 429
>CE28642 [U] KOG0938 Adaptor complexes medium subunit family
Length = 482
Score = 287 bits (734), Expect = 3e-77
Identities = 158/432 (36%), Positives = 259/432 (59%), Gaps = 13/432 (3%)
Query: 11 KGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQYNDVYVLAL 70
KG+ L+SR Y+DDV+++AV++F+ ++ Q+ V P + + +V+ +V++ A+
Sbjct: 11 KGEVLISRIYRDDVTRNAVDAFRVNVIHARQQ--VRSPVTNMARTSFFHVKRGNVWICAV 68
Query: 71 TRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDKGVPQVTETK 130
TR +VNA +F F+ + + ++++N+++IYELLDE++D G PQ T+
Sbjct: 69 TRQ-NVNAAMVFEFLKRFADTMQSYFGKLNEENVKNNFVLIYELLDEILDFGYPQNTDPG 127
Query: 131 MLKQYITQKSFKLTRSAKK--QKNVARPPTELTNSVSWRPEGIKYKKNEAFLDVIESINM 188
+LK +ITQ+ + + ++ ++ +++T + WR EGIKY++NE FLDVIE +N+
Sbjct: 128 VLKTFITQQGVRTADAPVPVTKEEQSQITSQVTGQIGWRREGIKYRRNELFLDVIEYVNL 187
Query: 189 LMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVSSKKKNSN 248
LM QQGQVL + + G V ++S LSGMP+ K G+NDK + S +P +K +
Sbjct: 188 LMNQQGQVLSAHVAGKVAMKSYLSGMPECKFGINDKITIEGKSKPGSDDP---NKASRAA 244
Query: 249 IELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKVQVHSGSR 308
+ ++D +FHQCV+L+KFE E I+FIPPDGE++LM YR + I+ V+ S ++
Sbjct: 245 VAIDDCQFHQCVKLTKFETEHAISFIPPDGEYELMRYRTTKDIQLPFRVIPLVREVSRNK 304
Query: 309 IEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILWKFSSFQG 368
+E+ K+ K +A +E+ IP P + +G K+ +NAI+WK G
Sbjct: 305 MEVKVVVKSNFKPSLLAQKLEVRIPTPPNTSGVQLICMKGKAKYKAGENAIVWKIKRMAG 364
Query: 369 GKEYSMAAQLGLPSVSDAEPPKLKR-PVQIKFQIPYFTTSGIQVRYLKIEEPKLQYNSY- 426
KE ++A++ L S + E K R PV + F++P F SG++VRYLK+ EPKL Y+ +
Sbjct: 365 MKESQISAEIDLLSTGNVEKKKWNRPPVSMNFEVP-FAPSGLKVRYLKVFEPKLNYSDHD 423
Query: 427 --PWVRYITQSG 436
WVRYI +SG
Sbjct: 424 VIKWVRYIGRSG 435
>7300861 [U] KOG0938 Adaptor complexes medium subunit family
Length = 438
Score = 270 bits (691), Expect = 2e-72
Identities = 153/431 (35%), Positives = 255/431 (58%), Gaps = 14/431 (3%)
Query: 11 KGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQYNDVYVLAL 70
KG+ L+SR Y+DD+ ++AV++F+ ++ Q+ V P + + +++ ++++ A+
Sbjct: 11 KGEVLISRVYRDDIGRNAVDAFRVNVIHARQQ--VRSPVTNIARTSFFHIKRANIWLAAV 68
Query: 71 TRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDKGVPQVTETK 130
T+ +VNA +F F+ K+I +I++N+++IYELLDE++D G PQ T++
Sbjct: 69 TKQ-NVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNTDSG 127
Query: 131 MLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLDVIESINMLM 190
LK +ITQ+ K SA K++ + + +++T + WR EGIKY++NE FLDV+E +N+LM
Sbjct: 128 TLKTFITQQGIK---SATKEEQM-QITSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLM 183
Query: 191 TQQGQVLRSEILGTVKVRSRLS-GMPDLKLGLNDKGIFTTNDQE-DSPEPVVSSKKKNSN 248
+ QGQVL + + G V ++S LS GMP+ K G+NDK + + + +S+
Sbjct: 184 SPQGQVLSAHVAGKVVMKSYLSVGMPECKFGINDKIVMESKGRGLSGNSEAETSRSGKPV 243
Query: 249 IELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKVQVHSGSR 308
+ ++D +FHQCV+LSKFE E I+FIPPDGEF+LM YR + I V+ ++
Sbjct: 244 VVIDDCQFHQCVKLSKFETEHSISFIPPDGEFELMRYRTTKDISLPFRVIPLVREVGRTK 303
Query: 309 IEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILWKFSSFQG 368
+E+ K+ K + +E+ IP P + +G K+ +NAI+WK G
Sbjct: 304 MEVKVVLKSNFKPSLLGQKIEVKIPTPLNTSGVQLICLKGKAKYKASENAIVWKIKRMAG 363
Query: 369 GKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPKLQYNSY-- 426
KE ++A++ L +D + + P+ + F++P F SG +VRYLK+ EPKL Y+ +
Sbjct: 364 MKETQLSAEIELLE-TDTKKKWTRPPISMNFEVP-FAPSGFKVRYLKVFEPKLNYSDHDV 421
Query: 427 -PWVRYITQSG 436
WVRYI +SG
Sbjct: 422 VKWVRYIGRSG 432
>SPAC31A2.09c [U] KOG0938 Adaptor complexes medium subunit family
Length = 446
Score = 236 bits (602), Expect = 5e-62
Identities = 147/446 (32%), Positives = 233/446 (51%), Gaps = 16/446 (3%)
Query: 1 MASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYV 60
M S + + KG L+ + ++ D+ +S E F+ +L + P Y+Y
Sbjct: 1 MISGLFIFNLKGDTLICKTFRHDLKKSVTEIFRVAILTN---TDYRHPIVSIGSSTYIYT 57
Query: 61 QYNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMD 120
++ D+YV+A+T+ + N + F+ LI +++DN I+ELLDEM+D
Sbjct: 58 KHEDLYVVAITKG-NPNVMIVLEFLESLIQDLTHYFGKLNENTVKDNVSFIFELLDEMID 116
Query: 121 KGVPQVTETKMLKQYITQKSFKLTRSAKKQKN------VARPPTELTNSVSWRPEGIKYK 174
G+ Q TE L + ++ + K +A K +E+ SV WR GIKY+
Sbjct: 117 YGIIQTTEPDALARSVSITAVKKKGNALSLKRSHSSQLAHTTSSEIPGSVPWRRAGIKYR 176
Query: 175 KNEAFLDVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQED 234
KN ++D++E +N+L++ G VLRS++ G VK+R+ LSGMP+ + GLNDK F E
Sbjct: 177 KNSIYIDIVERMNLLISSTGNVLRSDVSGVVKMRAMLSGMPECQFGLNDKLDFKLKQSES 236
Query: 235 SPEPVVSSKKKNSN---IELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPI 291
+ S + N + LED +FHQCVRL +FENE ITFIPPDGE +LM+YR I
Sbjct: 237 KSKSNNSRNPSSVNGGFVILEDCQFHQCVRLPEFENEHRITFIPPDGEVELMSYRSHENI 296
Query: 292 KPLIWCDVKVQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIK 351
V+ S +I +A K +++++ IP+P + + +RG
Sbjct: 297 NIPFRIVPIVEQLSKQKIIYRISIRADYPHK-LSSSLNFRIPVPTNVVKANPRVNRGKAG 355
Query: 352 WVPEKNAILWKFSSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQV 411
+ P +N I WK F G E A++ L + ++ + K P+ + F I FT+SG+ V
Sbjct: 356 YEPSENIINWKIPRFLGETELIFYAEVELSNTTN-QQIWAKPPISLDFNILMFTSSGLHV 414
Query: 412 RYLKIEEP-KLQYNSYPWVRYITQSG 436
+YL++ EP +Y S WVRY T++G
Sbjct: 415 QYLRVSEPSNSKYKSIKWVRYSTRAG 440
>At4g24550 [U] KOG0937 Adaptor complexes medium subunit family
Length = 451
Score = 210 bits (535), Expect = 3e-54
Identities = 130/462 (28%), Positives = 236/462 (50%), Gaps = 31/462 (6%)
Query: 1 MASYVAFCDSKGKPLLSRRYQDDVSQSAVESF-QHLLLEREQESSVMPPCFHHNGIHYMY 59
M S +G ++ R Y+ +V + + E+F + + +E ++ PP F+ +G++Y +
Sbjct: 2 MISQFFVLSQRGDNIVFRDYRAEVPKGSTETFFRKVKFWKEDGNAEAPPIFNVDGVNYFH 61
Query: 60 VQYNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMM 119
V+ +Y +A TR V+V+ + + + ++ S R N++++YELLDE++
Sbjct: 62 VKVVGLYFVATTR-VNVSPSLVLELLQRIARVIKDYLGVLNEDSFRKNFVLVYELLDEVI 120
Query: 120 DKGVPQVTETKMLKQYITQKSFKLTRSAKKQKNVAR---------PPTELTNSVSWRPEG 170
D G Q T T++LK YI + ++ + + + A P T +T SV G
Sbjct: 121 DFGYVQTTSTEVLKSYIFNEPIVVSPARLQPIDPAAIFTQGAKRMPGTAVTKSVVANDPG 180
Query: 171 IKYKKNEAFLDVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLND-----KG 225
+ ++ E F+D+IE I++ + G +L SEI GT++++S LSG P+++L LN+ +G
Sbjct: 181 GR-RREEIFVDIIEKISVTFSSSGYILTSEIDGTIQMKSYLSGNPEIRLALNEDLNIGRG 239
Query: 226 IFTTNDQEDSPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTY 285
+ D S S + L+D FH+ VRL F++++ ++ +PPDGEF +M Y
Sbjct: 240 GRSVYDYRSS---------SGSGVILDDCNFHESVRLDSFDSDRTLSLVPPDGEFPVMNY 290
Query: 286 RLSTPIKPLIWCDVKVQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKY 345
R++ KP + ++ + E+ + +A+ +AN + + +P+P +F+
Sbjct: 291 RMTQEFKPPFHVNTLIEEAGRLKAEVIIKIRAEFPSDIIANTITVQMPLPNYTSRASFEL 350
Query: 346 ---SRGNIKWVPEKNAIL-WKFSSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQI 401
+ G E N +L W GG E+++ A+L K PV + F I
Sbjct: 351 EPGAAGQRTDFKESNKMLEWNLKKIVGGGEHTLRAKLTFSQEFHGNITKEAGPVSMTFTI 410
Query: 402 PYFTTSGIQVRYLKIEEPKLQYNSYPWVRYITQSGDDYTIRL 443
P + S +QV+YL+I + YN Y WVRY+TQ+ + Y R+
Sbjct: 411 PMYNVSKLQVKYLQIAKKSSSYNPYRWVRYVTQA-NSYVARI 451
>YOL062c [U] KOG0938 Adaptor complexes medium subunit family
Length = 491
Score = 178 bits (452), Expect = 1e-44
Identities = 134/500 (26%), Positives = 237/500 (46%), Gaps = 68/500 (13%)
Query: 1 MASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLER-EQESSVMPPCFHHNGIHYMY 59
M S V S+G+ +L++ +++ + +S + F+ ++ + S V+ H++
Sbjct: 1 MISGVLVYSSRGELVLNKFFKNSLKRSISDIFRVQVINNLDVRSPVLT--LGSTTFHHIR 58
Query: 60 VQYND-VYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEM 118
++ D ++++ +TRS + N+ ++ F+YKL + ++++ ++I++E+LD M
Sbjct: 59 SRHGDNLWLVTITRS-NANSAAIWEFLYKL-DAVMNAYRLDREEALKEEFMIVHEMLDIM 116
Query: 119 MD-KGVPQVTETKMLKQYITQKSFKLTR-------------------SAKKQKNVARPPT 158
+ G+P TE L I Q S K R S P
Sbjct: 117 LGGNGIPIDTE---LNSVIAQMSVKPVRNMGGLLDSPDGNDVLSSSSSPTSSAGELHFPK 173
Query: 159 ELT-------------------NSVSWRPEGIKYKKNEAFLDVIESINMLMTQQGQVLRS 199
LT N ++WRP+GI +KK+E FL V E IN+L+++ G +L+S
Sbjct: 174 FLTKRSSSFLGQGDSTSDFYDNNKITWRPKGIIHKKDEVFLYVNERINILVSRDGSILKS 233
Query: 200 EILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQE------------DSPEPVVSSKKKNS 247
+ GT+ + + LSG P + GLND + D++ D K
Sbjct: 234 YVDGTIDITTHLSGTPICRFGLNDSLGMQSEDEKKWLAQQQRHSGSDFGNKNFIPKAAAG 293
Query: 248 NIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIK-PLIWCDVKVQVHSG 306
++ LED KFH+CV L KF II F+PPDG +LM Y + I P +
Sbjct: 294 SVLLEDCKFHECVSLDKFNRNHIIEFVPPDGSMELMKYHVRDNINLPFKVTPIVTHSTRD 353
Query: 307 SRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILWKFSSF 366
+ I+ K+ K A +V + IP+P S G+ K+VPE+NA++W+F+ +
Sbjct: 354 NEIDYRITLKSLFPGKLSAKDVVLHIPVPPSTVDCKISVSNGHCKFVPEENAMIWRFNKY 413
Query: 367 QGGKEYSMAAQLGLPSVSDAEPPKLKR----PVQIKFQIPYFTTSGIQVRYLKIEEPKLQ 422
G E +++A S SD L++ P+ ++F++ F+ SG+ VRY I +
Sbjct: 414 NGLTENTLSAV--TVSTSDTTQLNLQQWTRPPISLEFEVMMFSNSGLVVRYFTISGKDSK 471
Query: 423 YNSYPWVRYITQSGDDYTIR 442
+ + W++YI+++G Y +R
Sbjct: 472 HRAVKWIKYISKAG-SYEVR 490
>Hs14917111 [U] KOG0937 Adaptor complexes medium subunit family
Length = 453
Score = 171 bits (434), Expect = 2e-42
Identities = 127/470 (27%), Positives = 231/470 (49%), Gaps = 44/470 (9%)
Query: 1 MASYVAFCDSKGKPLLSRRYQDDVS-QSAVESFQHLLLEREQESSVMPPCFHHNGIHYMY 59
M S SKG PL+ + ++ D + E F L + S P HH+G H+++
Sbjct: 1 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDES--PVVMHHHGRHFIH 58
Query: 60 VQYNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMM 119
++++ +Y L +T S +V+ ++ + +L +I N ++YELLDE++
Sbjct: 59 IRHSGLY-LVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVL 117
Query: 120 DKGVPQVTETKMLKQYI-----TQKSFKLTR-------SAKKQKNVARPPTELTNSV-SW 166
D G Q T T+ML+ +I K F L A+ Q++ P + + V S
Sbjct: 118 DYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSS 177
Query: 167 RPEGIKYKKNEAFLDVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGI 226
R + + +KNE FLDV+E +++L+ G +L+ ++ G ++++S L ++++GL ++
Sbjct: 178 RSD--QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE-- 233
Query: 227 FTTNDQEDSPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYR 286
F E + I ++++ FH V L +FE+ +I+ PP GE +M Y+
Sbjct: 234 FCVGKSE--------LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQ 285
Query: 287 LS----TPIKPLIWCDVKVQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPT 342
LS +P+ ++ V+ SG R++++ + + + KS A NV + +P+P S +
Sbjct: 286 LSDDLPSPLPFRLFPSVQWDRGSG-RLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLS 344
Query: 343 FKYSRGNIKWVPEKNAILWKFSSFQGGKEYSMAAQLGLP--------SVSDAEPPKLKRP 394
+ S K + A+ W QGG + S Q+ +P +S + P P
Sbjct: 345 QELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGP 404
Query: 395 VQIKFQIPYFTTSGIQVRYLKIE-EPKLQYNSYPWVRYITQSGDDYTIRL 443
+ F++P T SG+QVR+L++ P N + WVR+++ S D Y IR+
Sbjct: 405 ASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHS-DAYVIRI 453
>Hs6912240 [U] KOG2740 Clathrin-associated protein medium chain
Length = 418
Score = 157 bits (397), Expect = 3e-38
Identities = 113/433 (26%), Positives = 196/433 (45%), Gaps = 40/433 (9%)
Query: 12 GKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQYNDVYVLALT 71
G L + ++ VSQS + F E+ + +PP HY+ Y D
Sbjct: 12 GDIFLEKHWKSVVSQSVCDYFFEAQ-EKAADVENVPPVIS-TPHHYLISIYRDKLFFVSV 69
Query: 72 RSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDKGVPQVTETKM 131
V + F++++ + +I+DN +I+YELL+EM+D G P TE+ +
Sbjct: 70 IQTEVPPLFVIEFLHRVADTFQDYFGECSEAAIKDNVVIVYELLEEMLDNGFPLATESNI 129
Query: 132 LKQYITQKSF--KLTRSAKKQKNVARP-PTELTNSVSWRPEGIKYKKNEAFLDVIESINM 188
LK+ I + + S NV PT +++ WR G+KY NEA+ DV+E I+
Sbjct: 130 LKELIKPPTILRSVVNSITGSSNVGDTLPTGQLSNIPWRRAGVKYTNNEAYFDVVEEIDA 189
Query: 189 LMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVSSKKKNSN 248
++ + G + +EI G + +LSGMPDL L + +
Sbjct: 190 IIDKSGSTVFAEIQGVIDACIKLSGMPDLSLSFMNPRL---------------------- 227
Query: 249 IELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKVQV----- 303
L+D+ FH C+R ++E+E++++FIPPDG F L++YR+S+ I VK +
Sbjct: 228 --LDDVSFHPCIRFKRWESERVLSFIPPDGNFRLISYRVSSQNLVAIPVYVKHSISFKEN 285
Query: 304 HSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILWKF 363
S R +I K + K + + + +P+ + ++G+ + P + W
Sbjct: 286 SSCGRFDITIGPKQNMGK--TIEGITVTVHMPKVVLNMNLTPTQGSYTFDPVTKVLTWDV 343
Query: 364 SSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPKLQY 423
K S+ + L S A P+ + I+F+I SG++V L + K Y
Sbjct: 344 GKITPQKLPSLKGLVNLQ--SGAPKPEENPSLNIQFKIQQLAISGLKVNRLDMYGEK--Y 399
Query: 424 NSYPWVRYITQSG 436
+ V+Y+T++G
Sbjct: 400 KPFKGVKYVTKAG 412
>Hs5803000 [U] KOG2740 Clathrin-associated protein medium chain
Length = 418
Score = 152 bits (383), Expect = 1e-36
Identities = 113/436 (25%), Positives = 201/436 (45%), Gaps = 40/436 (9%)
Query: 9 DSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQYNDVYVL 68
+S G L + ++ VS+S + F ER E+ +PP + + V + ++ +
Sbjct: 9 NSSGDIFLEKHWKSVVSRSVCDYFFEAQ-ERATEAENVPPVIPTPHHYLLSVYRHKIFFV 67
Query: 69 ALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDKGVPQVTE 128
A+ ++ V + F++++++ I+DN +++YE+L+EM+D G P TE
Sbjct: 68 AVIQT-EVPPLFVIEFLHRVVDTFQDYFGVCSEPVIKDNVVVVYEVLEEMLDNGFPLATE 126
Query: 129 TKMLKQYITQKSFKLT--RSAKKQKNVA-RPPTELTNSVSWRPEGIKYKKNEAFLDVIES 185
+ +LK+ I + T + NV + PT + V WR G+KY NEA+ DVIE
Sbjct: 127 SNILKELIKPPTILRTVVNTITGSTNVGDQLPTGQLSVVPWRRTGVKYTNNEAYFDVIEE 186
Query: 186 INMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVSSKKK 245
I+ ++ + G + +EI G + +L+GMPDL L + +
Sbjct: 187 IDAIIDKSGSTITAEIQGVIDACVKLTGMPDLTLSFMNPRL------------------- 227
Query: 246 NSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKVQV-- 303
L+D+ FH CVR ++E+E+I++FIPPDG F L++Y +S I VK +
Sbjct: 228 -----LDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHVSAQNLVAIPVYVKHNISF 282
Query: 304 ---HSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAIL 360
S R EI K + K V + +P+ + + S+G + P +
Sbjct: 283 RDSSSLGRFEITVGPKQTMGK--TIEGVTVTSQMPKGVLNMSLTPSQGTHTFDPVTKMLS 340
Query: 361 WKFSSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPK 420
W K S+ + L + A P + ++F+I SG++V L + K
Sbjct: 341 WDVGKINPQKLPSLKGTMSLQ--AGASKPDENPTINLQFKIQQLAISGLKVNRLDMYGEK 398
Query: 421 LQYNSYPWVRYITQSG 436
Y + ++Y+T++G
Sbjct: 399 --YKPFKGIKYMTKAG 412
>7290785 [U] KOG2740 Clathrin-associated protein medium chain
Length = 422
Score = 147 bits (372), Expect = 2e-35
Identities = 107/436 (24%), Positives = 198/436 (44%), Gaps = 43/436 (9%)
Query: 9 DSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQYNDVYVL 68
+S G+ L + ++ VS+S E F L+ ++ + P +Y+ D L
Sbjct: 9 NSGGEVFLEKHWRSVVSRSVCEYF----LDAQRAAPYDVPPVIATPHYYLITVQRDTVSL 64
Query: 69 ALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDKGVPQVTE 128
V + F++++++ I+DNY+++YELLDEM+D G P TE
Sbjct: 65 VAACKQEVPPLFVIEFLHRVVDTFQDYFGDCSESVIKDNYVVVYELLDEMLDNGFPLATE 124
Query: 129 TKMLKQYITQKSFKLT--RSAKKQKNVARP-PTELTNSVSWRPEGIKYKKNEAFLDVIES 185
+ +LK+ I + T + + NV+ P+ ++V WR G++Y NEA+ DVIE
Sbjct: 125 SNILKELIKPPNILRTIANTVTGKSNVSTTLPSGQLSAVRWRRSGVRYTNNEAYFDVIEE 184
Query: 186 INMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVSSKKK 245
++ ++ + G + +EI G + +LSGMPDL L + +F
Sbjct: 185 VDAIIDKSGSTVFAEIQGHIDCCIKLSGMPDLTLSFMNPRLF------------------ 226
Query: 246 NSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLSTP--IKPLIWCDVKVQV 303
+D+ FH CVR ++E E++++FIPPDG F LM+Y +S+ + I+ +
Sbjct: 227 ------DDVSFHPCVRYKRWEAERLLSFIPPDGNFRLMSYHISSQSVVAIPIYIRHNFSI 280
Query: 304 HSGSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILWKF 363
+G + + + + V++ + +P + ++G + + W
Sbjct: 281 KTGEQGRLDLTIGPRNTLGRTVDKVKLELTMPRCVLNCLLTPNQGKYTFDSVTKTLSWDV 340
Query: 364 SSFQGGKEYSMAAQLGL-PSVS--DAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEPK 420
K ++ + + P + DA P V ++FQI SG++V L + K
Sbjct: 341 GRIDVSKLPNIRGSVSITPGTTNIDANP-----SVNVQFQISQLAVSGLKVNRLDMYGEK 395
Query: 421 LQYNSYPWVRYITQSG 436
Y + V+Y+T++G
Sbjct: 396 --YKPFKGVKYLTKAG 409
>CE04654 [U] KOG2740 Clathrin-associated protein medium chain
Length = 332
Score = 145 bits (366), Expect = 1e-34
Identities = 86/294 (29%), Positives = 150/294 (50%), Gaps = 35/294 (11%)
Query: 1 MASYVAFCDSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMP---PCFHHNGIHY 57
M + + F +S G LL + ++ + +S + F + Q+ S+ P P HY
Sbjct: 1 MLNSLFFVNSSGDVLLEKHWKSVIHRSICDYFFDI-----QKKSIHPEDVPPIISTPHHY 55
Query: 58 MYVQYNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDE 117
+ Y + L +V + F++++I S+++N ++++ELLDE
Sbjct: 56 LINVYQNNLFLVAVITVETPPLMVIEFLHRVIQTFTQYFDEFSDSSMKENCVMVFELLDE 115
Query: 118 MMDKGVPQVTETKMLKQYITQKSF--KLTRSAKKQKNVARP-PTELTNSVSWRPEGIKYK 174
M+D G P VTE +L+ I +F + + N++ PT +++ WR +G+KY
Sbjct: 116 MLDNGFPLVTEMNILQDLIKPPNFLRNIANQVTGRTNLSETLPTGQLSNIPWRRQGVKYT 175
Query: 175 KNEAFLDVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQED 234
NEA+ DVIE I++++ +QG + +EI G V V +LSGMPDL + L + +
Sbjct: 176 NNEAYFDVIEEIDVIVDKQGSTVFAEIQGYVDVCCKLSGMPDLTMTLINPRL-------- 227
Query: 235 SPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRLS 288
L+D+ FH CVR ++ENEK+++F+PPDG F L++Y ++
Sbjct: 228 ----------------LDDVSFHPCVRYKRWENEKVLSFVPPDGNFRLLSYHIA 265
>At1g56590 [U] KOG2740 Clathrin-associated protein medium chain
Length = 417
Score = 134 bits (336), Expect = 4e-31
Identities = 108/405 (26%), Positives = 179/405 (43%), Gaps = 59/405 (14%)
Query: 56 HYMYVQYNDVYVLALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELL 115
HY++ D V + F+ ++ + I+DN+II+YELL
Sbjct: 55 HYLFQIVRDGITFLACSQVEMPPLMAIEFLCRVADVLSEYLGGLNEDLIKDNFIIVYELL 114
Query: 116 DEMMDKGVPQVTETKMLKQYITQKSF---KLTRSAKKQKNVARP-PTELTNSVSWRPEGI 171
DEM+D G P TE +LK+ I + L+ NV+ P+ + V WRP
Sbjct: 115 DEMIDNGFPLTTEPSILKEMIAPPNLVSKMLSVVTGNASNVSDTLPSGAGSCVPWRPTDP 174
Query: 172 KYKKNEAFLDVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTND 231
KY NE ++D++E ++ ++ + G++++ EI G V++ S+L+G PDL L + I
Sbjct: 175 KYSSNEVYVDLVEEMDAIVNRDGELVKCEIYGEVQMNSQLTGFPDLTLSFANPSI----- 229
Query: 232 QEDSPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEFDLMTYRL---- 287
LED++FH CVR +E+ ++++F+PPDGEF LM+YR
Sbjct: 230 -------------------LEDMRFHPCVRYRPWESHQVLSFVPPDGEFKLMSYRCVVKK 270
Query: 288 --STPIKPLIWCDVKVQVHSGSRIEIHCRAKAQIKKKS----VANNVEILIPIPEDADSP 341
+TP+ VK Q+ S S CR + +S ++ + +P S
Sbjct: 271 LKNTPVY------VKPQITSDSGT---CRISVLVGIRSDPGKTIESITLSFQLPHCVSSA 321
Query: 342 TFKYSRGNIKWVPEKNAILWKFSSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQI 401
+ G + + K W K ++ L L EP + V F++
Sbjct: 322 DLSSNHGTVTILSNKTC-TWTIGRIPKDKTPCLSGTLAL------EPGLERLHVFPTFKL 374
Query: 402 PYFTTSGIQVRYLKIEEPKLQY---NSYPWVRYITQSGDDYTIRL 443
F GI + L+IE+ LQ Y R T++G ++ +RL
Sbjct: 375 G-FKIMGIALSGLRIEKLDLQTIPPRLYKGFRAQTRAG-EFDVRL 417
>YHL019c [U] KOG0937 Adaptor complexes medium subunit family
Length = 605
Score = 120 bits (301), Expect = 4e-27
Identities = 99/347 (28%), Positives = 157/347 (44%), Gaps = 74/347 (21%)
Query: 164 VSWRPEGIKYKKNEAFLDVIESINMLMTQQGQVLRSEIL-GTVKVRSRLSGMPDLKLGLN 222
+SWR +GI Y KNE FLDVIE + LM + V+R ++ G + R LSGMP LK+ +N
Sbjct: 258 ISWRTKGIHYAKNEFFLDVIERVQYLMDFEKGVIRKNLIHGEIVCRCYLSGMPKLKISIN 317
Query: 223 DKGIFTTNDQ---EDSPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGE 279
I + Q S VS N+ + E+ L + + I FIPPDGE
Sbjct: 318 K--ILNRDPQFMSNSSFHQCVSLDSINTIEKDEEKNSDDDAGLQAATDAREIEFIPPDGE 375
Query: 280 FDLMTYRLSTPIK--PLIWC---DVKVQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPI 334
F L Y L +K P++ ++K ++ +I+I + + K + + + + IP+
Sbjct: 376 FVLCQYELKRHVKDAPMVRLKDFEIKPKLKK-FKIQIVTKIQTNFKPTNSTSKLNVRIPL 434
Query: 335 P--------EDADSPTFKYSRGNIKWVPEKNAILWKFSSFQGGKEY-------------- 372
+ + FK + G + + + +LW+ + +G +E+
Sbjct: 435 TKVFQEYKIDLSKQIRFKANIGKVVFNLSDDFLLWEIQTMKGHREHSTNKSSQYNSDEDD 494
Query: 373 -----SMAAQLGLPSVSDAE-----------PPKLK------------------------ 392
SM A+ L + + + PP L+
Sbjct: 495 PNTCASMVAEFPLFNQEEYDRLQEEMKTSMNPPPLRTGPRLEELYRQVHDQQTSHVTPRD 554
Query: 393 RPVQIKFQIPYFTTSGIQVRYLKIEEPKLQYNSYPWVRYITQSGDDY 439
+ V I F+IPY T SG++V YLK+EEP+LQY S+PWVRY T S ++Y
Sbjct: 555 KLVNIDFEIPYCTCSGLKVEYLKVEEPQLQYQSFPWVRYKTVSDEEY 601
>Hs17461156 [U] KOG0937 Adaptor complexes medium subunit family
Length = 124
Score = 107 bits (267), Expect = 4e-23
Identities = 59/130 (45%), Positives = 82/130 (62%), Gaps = 17/130 (13%)
Query: 127 TETKMLKQYITQKSFKLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLDVIESI 186
T +K+L++Y TQ+S KL R K P + N+VSW E IKYKKNE F+DVIES
Sbjct: 3 TNSKILQEYTTQQSNKLQRGKSKV------PLTINNAVSWCSERIKYKKNEVFIDVIESA 56
Query: 187 NMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVSSKKKN 246
N+L+ +G +L SEI GT+K++ LSGMP+L+LGLND +F ++ KN
Sbjct: 57 NLLVNAKGSILLSEIFGTIKLKVFLSGMPELRLGLNDSMLFE-----------LTGCHKN 105
Query: 247 SNIELEDLKF 256
++LED+KF
Sbjct: 106 KLVKLEDVKF 115
>SPBC651.11c [U] KOG2740 Clathrin-associated protein medium chain
Length = 425
Score = 86.3 bits (212), Expect = 9e-17
Identities = 80/337 (23%), Positives = 139/337 (40%), Gaps = 35/337 (10%)
Query: 9 DSKGKPLLSRRYQDDVSQSAVESFQHLLLEREQESSVMPPCFHHNGIHYMYVQYNDVYVL 68
D+ G LL + S +E ++ L R + + PP HN ++ + + L
Sbjct: 11 DTNGALLLQLESRGRTSPITLEHIKNELF-RYKLRNEEPPFILHNKNFLIFQELEEDVRL 69
Query: 69 ALTRSVSVNATTMFAFMYKLINXXXXXXXXXXXXSIRDNYIIIYELLDEMMDKGVPQVTE 128
+ + + M ++++ + N +I +LL EM+D G E
Sbjct: 70 CIPTTCDTEPLYIHDIMRRIVDVVKTFFGGFNASKVEKNVCVIVQLLAEMIDYGYATCME 129
Query: 129 TKMLKQYITQKSF--KLTRSAKKQKNVARPPTELTNSVSWRPEGIKYKKNEAFLDVIESI 186
L+ + SF K Q N PT ++V WR KY NE F+ V+E +
Sbjct: 130 PNALQDIVPLPSFMNKFMAVTGLQTNT---PTLARDTVPWRTAKAKYATNEFFIHVLERV 186
Query: 187 NMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQEDSPEPVVSSKKKN 246
+ + G++ + ++ + ++SGMP L L L
Sbjct: 187 SAVYQPNGKLAFGTVKSDMECKCQISGMPLLLLSL------------------------R 222
Query: 247 SNIELEDLKFHQCVRLSKF-ENEKIITFIPPDGEFDLMTYRLSTPIKPLIWCDVKVQVHS 305
+L +++FHQ V L ++ ++ I FIPPDG+F L +++ + + V+ +
Sbjct: 223 PGTKLGNVRFHQSVNLKRWKQHPDQIEFIPPDGKFTLASFQTDFATQKSLPVVVEAKNKL 282
Query: 306 GSRIEIHCRAKAQIKKKSVANNVEILIPIPEDADSPT 342
R E+ R KKSV N++ILI IP+ S T
Sbjct: 283 DGRFEVRIR---NTGKKSV-ENLKILITIPQALKSVT 315
>HsM14916441 [U] KOG2677 Stoned B synaptic vesicle biogenesis protein
Length = 702
Score = 65.5 bits (158), Expect = 2e-10
Identities = 70/312 (22%), Positives = 122/312 (38%), Gaps = 60/312 (19%)
Query: 170 GIKYKKNEAFLDVIESINMLMTQ-QGQVLRSEILGTVKVRSRLSGMPDLKLGLND---KG 225
G+ Y + E +DV + + ++++ Q+L+ +L + + S LSG+ + +LGLND KG
Sbjct: 360 GLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKG 419
Query: 226 IFTTNDQEDSPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDG-EFDLMT 284
Q+ P I+L + +FH CV F N ++I F P D F+LM
Sbjct: 420 NEIVLRQDIMPTTTTKW------IKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMR 473
Query: 285 YRLSTPIKPLIWC--------DVKVQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPE 336
+R K L + +V+V S R+ A + NV I P+P
Sbjct: 474 FRTVFAEKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPS 533
Query: 337 D--------------------------------ADSPTFKYSRGNIKWVPEKNAILWKFS 364
+ P + + G K+ N+I+W+ +
Sbjct: 534 EWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRIN 593
Query: 365 -----SFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEP 419
+ G + L L S + P + V ++F +P + S VR + +E+
Sbjct: 594 RLPDKNSASGHPHCFFCHLELGSDREV-PSRFANHVNVEFSMPTTSASKASVRSISVED- 651
Query: 420 KLQYNSYPWVRY 431
+ + WV Y
Sbjct: 652 --KTDVRKWVNY 661
>Hs21361863 [U] KOG2677 Stoned B synaptic vesicle biogenesis protein
Length = 905
Score = 65.5 bits (158), Expect = 2e-10
Identities = 70/312 (22%), Positives = 122/312 (38%), Gaps = 60/312 (19%)
Query: 170 GIKYKKNEAFLDVIESINMLMTQ-QGQVLRSEILGTVKVRSRLSGMPDLKLGLND---KG 225
G+ Y + E +DV + + ++++ Q+L+ +L + + S LSG+ + +LGLND KG
Sbjct: 563 GLNYLEEEITVDVRDEFSGIVSKGDNQILQHHVLTRIHILSFLSGLAECRLGLNDILVKG 622
Query: 226 IFTTNDQEDSPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDG-EFDLMT 284
Q+ P I+L + +FH CV F N ++I F P D F+LM
Sbjct: 623 NEIVLRQDIMPTTTTKW------IKLHECRFHGCVDEDVFHNSRVILFNPLDACRFELMR 676
Query: 285 YRLSTPIKPLIWC--------DVKVQVHSGSRIEIHCRAKAQIKKKSVANNVEILIPIPE 336
+R K L + +V+V S R+ A + NV I P+P
Sbjct: 677 FRTVFAEKTLPFTLRTATSVNGAEVEVQSWLRMSTGFSANRDPLTQVPCENVMIRYPVPS 736
Query: 337 D--------------------------------ADSPTFKYSRGNIKWVPEKNAILWKFS 364
+ P + + G K+ N+I+W+ +
Sbjct: 737 EWVKNFRRESVLGEKSLKAKVNRGASFGSTSVSGSEPVMRVTLGTAKYEHAFNSIVWRIN 796
Query: 365 -----SFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRYLKIEEP 419
+ G + L L S + P + V ++F +P + S VR + +E+
Sbjct: 797 RLPDKNSASGHPHCFFCHLELGSDREV-PSRFANHVNVEFSMPTTSASKASVRSISVED- 854
Query: 420 KLQYNSYPWVRY 431
+ + WV Y
Sbjct: 855 --KTDVRKWVNY 864
>Hs5803153_1 [U] KOG2677 Stoned B synaptic vesicle biogenesis protein
Length = 708
Score = 55.1 bits (131), Expect = 2e-07
Identities = 62/290 (21%), Positives = 116/290 (39%), Gaps = 51/290 (17%)
Query: 173 YKKNEAFLDVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGIFTTNDQ 232
Y++ E L+++++ +T++G+ + S ++ + ++G + L LND + +
Sbjct: 410 YEEQEISLEIVDNFWGKVTKEGKFVESAVITQIYCLCFVNGNLECFLTLNDLEL----PK 465
Query: 233 EDSPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDG-EFDLMTYRLSTPI 291
D S+KK I++ D FH+CV + +FE +II F+P D F+LM ++
Sbjct: 466 RDESYYEKDSEKKG--IDILDYHFHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTLYNG 523
Query: 292 KPLIWCDVKVQVHSGSRIEIHCRAK-AQIKKKS-------VANNVEILIPIP-------- 335
L + V V G+ +E+ A + ++S +N+ I P+P
Sbjct: 524 DNLPFSLKSVVVVQGAYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALW 583
Query: 336 ------------------------EDADSPTFKYSRGNIKWVPEKNAILWKFSSF---QG 368
E P + + G+ K+ A++WK
Sbjct: 584 TMNLQRQKSLKAKMNRRACLGSLQELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNS 643
Query: 369 GKEYSMAAQLGLPSVSDAEPPKLKRP-VQIKFQIPYFTTSGIQVRYLKIE 417
++ L SD E P P ++F +P S +VR L +E
Sbjct: 644 SLDHPHCLSYKLELGSDQEIPSDWYPFATVQFSVPDTCASRTEVRSLGVE 693
>CE08425 [U] KOG2677 Stoned B synaptic vesicle biogenesis protein
Length = 1657
Score = 53.9 bits (128), Expect = 5e-07
Identities = 49/182 (26%), Positives = 80/182 (43%), Gaps = 27/182 (14%)
Query: 173 YKKNEAFLDVIESINMLMTQQGQVLRSEILGTVKVRSRL------SGMPDLKLGLNDKGI 226
YK++E + + + + ++G IL K R RL +G P L++GLND+
Sbjct: 1249 YKQDEVQIHCYDEYSAFVDKEG------ILSDQKARVRLFCLAFLTGSPVLEVGLNDR-- 1300
Query: 227 FTTNDQEDSPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDG-EFDLMTY 285
+E + I E L+FH V +F+ E++I F PPDG F++M +
Sbjct: 1301 -RRQGKEIVRRKDILPMYTERWIRFEALEFHSIVNKPEFDKEQVIAFSPPDGCFFEIMRF 1359
Query: 286 RLSTPIKPLIWCDVK-VQVHSGSRIEIHCRAKAQI----------KKKSVANNVEILIPI 334
R+ P VK + +GS++EI A A ++ ++ I PI
Sbjct: 1360 RVRPPRNREKAMTVKSIMKIAGSKVEIRIEAMAAAQIQRTRGSDERRNIPCEDIAIRFPI 1419
Query: 335 PE 336
PE
Sbjct: 1420 PE 1421
>7288911 [U] KOG2677 Stoned B synaptic vesicle biogenesis protein
Length = 1194
Score = 50.8 bits (120), Expect = 4e-06
Identities = 63/321 (19%), Positives = 119/321 (36%), Gaps = 57/321 (17%)
Query: 167 RPEGIKYKKNEAFLDVIESINMLMTQQGQVLRSEILGTVKVRSRLSGMPDLKLGLNDKGI 226
R + YK E + ++ I + +G++L+ + + L+GMP ++LG+ND
Sbjct: 827 RERALTYKMEEVQVTAVDEITVEQDFEGKILKQIARVRLFFLAFLTGMPTIELGVND--- 883
Query: 227 FTTNDQEDSPEPVVSSKKKNSNIELEDLKFHQCVRLSKFENEKIITFIPPDGEF-DLMTY 285
+E + I LE ++FH V ++E + I F PPD + +L+ +
Sbjct: 884 MWRQGKEVVGRHDIIPVATEEWIRLEAVEFHSVVNQKEYERTRTIKFQPPDANYIELLRF 943
Query: 286 RLSTPIK---PL----IWC----------------------------DVKVQVHSGS--- 307
R+ P PL WC DV V+
Sbjct: 944 RVRPPKNRELPLQLKATWCVSGNKVELRADILVPGFTSRKLGQIPCEDVSVRFPIPECWI 1003
Query: 308 ---RIEIHCR---AKAQIKKKSVANNVEILIPIPEDADSPTFKYSRGNIKWVPEKNAILW 361
R+E H R K+ ++ +E ++ + + + G K+ AI+W
Sbjct: 1004 YLFRVEKHFRYGSVKSAHRRTGKIKGIERILGAVDTLQESLIEVTSGQAKYEHHHRAIVW 1063
Query: 362 KF--------SSFQGGKEYSMAAQLGLPSVSDAEPPKLKRPVQIKFQIPYFTTSGIQVRY 413
+ F + + ++ L S D P +L ++F +P S VR
Sbjct: 1064 RCPRLPKEGQGEFGAYTTHQLVCRMALTSY-DQIPSELAPYAFVEFTMPATQVSHTTVRS 1122
Query: 414 LKIEEPKLQYNSYPWVRYITQ 434
+ +++ +VRY+ +
Sbjct: 1123 VSVQDSDGDEPPEKYVRYLAR 1143
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.134 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,013,709
Number of Sequences: 60738
Number of extensions: 1104158
Number of successful extensions: 3010
Number of sequences better than 1.0e-05: 30
Number of HSP's better than 0.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2881
Number of HSP's gapped (non-prelim): 33
length of query: 443
length of database: 30,389,216
effective HSP length: 109
effective length of query: 334
effective length of database: 23,768,774
effective search space: 7938770516
effective search space used: 7938770516
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)