ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV3747 good J KOG1069 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp46
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV3747 1267429 1266755 -225
(225 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGR095c [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subun... 221 5e-58
Hs9910360 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex sub... 91 1e-18
SPBC115.01c [J] KOG1069 Exosomal 3'-5' exoribonuclease complex s... 87 1e-17
CE20469 [J] KOG1068 Exosomal 3'-5' exoribonuclease complex subun... 56 4e-08
7299337 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subun... 56 4e-08
ECU10g0270 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex su... 56 5e-08
At3g46210 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex sub... 55 6e-08
At3g61620 [J] KOG1068 Exosomal 3'-5' exoribonuclease complex sub... 54 2e-07
Hs9506689 [J] KOG1068 Exosomal 3'-5' exoribonuclease complex sub... 51 1e-06
SPAC3G9.10c [J] KOG1068 Exosomal 3'-5' exoribonuclease complex s... 50 3e-06
SPBC211.08c [J] KOG1068 Exosomal 3'-5' exoribonuclease complex s... 50 3e-06
YGR195w [J] KOG1068 Exosomal 3'-5' exoribonuclease complex subun... 49 4e-06
CE02146 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subun... 49 6e-06
>YGR095c [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subunit Rrp46
Length = 256
Score = 221 bits (564), Expect = 5e-58
Identities = 114/217 (52%), Positives = 157/217 (71%), Gaps = 4/217 (1%)
Query: 7 VLGHVDGSSVVSNSGTKVICSVSGPMEPKSRQELPTQLALEIIVKPAEGVQSTREKLMED 66
+L HVDGSS + TKVICSV+GP+EPK+RQELPTQLALEIIV+PA+GV +TREK++ED
Sbjct: 42 ILDHVDGSSEFVSQDTKVICSVTGPIEPKARQELPTQLALEIIVRPAKGVATTREKVLED 101
Query: 67 QIRSVLTPVLARYLHPRQFVQICLQVLEAGESR-DYTVKEVSVCVNAAVLALVDAGVPLL 125
++R+VLTP++ R+ +PRQ QI Q+LE+GE +++++E+S C+NAA LALVDAG+ L
Sbjct: 102 KLRAVLTPLITRHCYPRQLCQITCQILESGEDEAEFSLRELSCCINAAFLALVDAGIALN 161
Query: 126 SMCSGTCIGITTEGKQLVVNPTESQLAKCESVHVYCLELGTNENGDIDVRNLLLLDSLGS 185
SMC+ I I + ++V+PT QL SVH LE NG V+N+LLLDS G
Sbjct: 162 SMCASIPIAIIKDTSDIIVDPTAEQLKISLSVHTLALEF---VNGGKVVKNVLLLDSNGD 218
Query: 186 FDESQLFKVLETGEKECIRLYTELRSVIKDKVAKDFV 222
F+E QLF +LE GE++C L T +R +I+D ++ V
Sbjct: 219 FNEDQLFSLLELGEQKCQELVTNIRRIIQDNISPRLV 255
>Hs9910360 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subunit Rrp46
Length = 235
Score = 91.3 bits (225), Expect = 1e-18
Identities = 61/214 (28%), Positives = 106/214 (49%), Gaps = 15/214 (7%)
Query: 6 HVLGHVDGSSVVSNSGTKVICSVSGPMEPKSRQELPTQLALEIIVKPAEGVQSTREKLME 65
++L DGS+ T V+ V GP E K +E+ + LE+I++P G+ EK E
Sbjct: 36 NLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRE 95
Query: 66 DQIRSVLTPVLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVDAGVPLL 125
IR+ V+ LHPR + + LQV+ S ++ C+NAA +ALVDAGVP+
Sbjct: 96 RLIRNTCEAVVLGTLHPRTSITVVLQVVSDAGSL------LACCLNAACMALVDAGVPMR 149
Query: 126 SMCSGTCIGITTEGKQLVVNPTESQLAKCESVHVYCLELGTNENGDIDVRNLLLLDSLGS 185
++ G + ++G LV++PT Q + +V + L D R LL+ + G
Sbjct: 150 ALFCGVACALDSDG-TLVLDPTSKQEKEARAVLTFAL--------DSVERKLLMSSTKGL 200
Query: 186 FDESQLFKVLETGEKECIRLYTELRSVIKDKVAK 219
+ +++L + L + ++ R ++ + +K
Sbjct: 201 YSDTELQQCLAAAQAASQHVFRFYRESLQRRYSK 234
>SPBC115.01c [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subunit Rrp46
Length = 226
Score = 87.4 bits (215), Expect = 1e-17
Identities = 56/193 (29%), Positives = 96/193 (49%), Gaps = 16/193 (8%)
Query: 7 VLGHVDGSSVVSNSGTKVICSVSGPMEPKSRQELPTQLALEIIVKPAEGVQSTREKLMED 66
+L DGSS +VIC V+GP++ K R E + +E++V+P GV T EK++
Sbjct: 6 ILSRSDGSSEWKQGSARVICGVNGPIDVKIRDERLNKATVEVLVQPVSGVAETLEKMISS 65
Query: 67 QIRSVLTPVLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVDAGVPLLS 126
+I +L + +PR +Q+ +Q++E + ++ +N AVLAL+DAG+ L
Sbjct: 66 RIVGILEDAIFLNTYPRTLIQVSIQIIE-----EDGTDTLAAVINGAVLALLDAGISLKY 120
Query: 127 M-CSGTCIGITTEGKQLVVNP-TESQLAKCESVHVYCLELGTNENGDIDVRNLLLLDSLG 184
+ C+ C + K P + + K ES+ C + + + L+ L++ G
Sbjct: 121 IPCAINC---HWKNKITQDEPDVDGTINKLESIITICYSISS------EPAKLIFLETAG 171
Query: 185 SFDESQLFKVLET 197
E F+VLET
Sbjct: 172 PIPEEDFFRVLET 184
>CE20469 [J] KOG1068 Exosomal 3'-5' exoribonuclease complex subunit Rrp41
and related exoribonucleases
Length = 240
Score = 56.2 bits (134), Expect = 4e-08
Identities = 52/208 (25%), Positives = 92/208 (44%), Gaps = 29/208 (13%)
Query: 10 HVDGSSVVSNSGTKVICSVSGPMEPKSRQELPTQLALEIIVKPA-----EGVQSTREKLM 64
+ +GS + + TKV+C+V GP E KS + + + A+ E TR
Sbjct: 31 NAEGSCYLEHGNTKVLCAVYGPYEGKSSKRIEDKCAIVCQYSATKFSGLERKNRTRGDRK 90
Query: 65 EDQIRSVLTP----VLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVDA 120
+I +L V+ PR + I +V++ S ++ CVNA LAL DA
Sbjct: 91 STEISRLLEKAFESVILTEAFPRSQLDIFCEVIQGDGSN------LAACVNATSLALADA 144
Query: 121 GVPLLSMCSGTCIGITTEGKQLV--VNPTESQLAKCESVHVYCLELGTNENGDIDVRNLL 178
G+P+ + S G+ +GK +V + E+ L ++ C G +E ++++N L
Sbjct: 145 GIPMKGIASAATCGV-VDGKPIVDLTSREETDLLPRVTLATIC---GRDEVILVELQNRL 200
Query: 179 LLDSLGSFDESQLFKVLETGEKECIRLY 206
+D L + V++ + C +Y
Sbjct: 201 HIDHLST--------VMDAAKATCADVY 220
>7299337 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subunit Rrp46
Length = 157
Score = 56.2 bits (134), Expect = 4e-08
Identities = 43/143 (30%), Positives = 68/143 (47%), Gaps = 7/143 (4%)
Query: 8 LGHVDGSSVVSNSGTKVICSVSGPMEPKSRQELPTQLALEIIVKPAEGVQSTREKLMEDQ 67
L DGS + S T +I +V GP+E K++ LE +P G+ +++ E
Sbjct: 18 LSRCDGSVMYSQGATGLIGAVLGPIEVKTQNLSIDGSYLECNYRPKAGLPQVTDRIREAA 77
Query: 68 IRSVLTPVLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVDAGVPLLSM 127
IR VL L HPR + + +Q LE S D + VN A LA++ G+PL
Sbjct: 78 IRDVLELALLSEAHPRSKMSVQIQELEDRGSID------ACAVNCACLAMLIGGLPLKYS 131
Query: 128 CSGTCIGITTEGKQLVVNPTESQ 150
+ I +G + V++P +S+
Sbjct: 132 FAAVHAIINEQG-EYVLDPDQSE 153
>ECU10g0270 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subunit Rrp46
Length = 188
Score = 55.8 bits (133), Expect = 5e-08
Identities = 41/128 (32%), Positives = 64/128 (49%), Gaps = 7/128 (5%)
Query: 1 METTTHVLGHVDGSSVVSNSGTKVICSVSGPMEPKSRQELPTQLALEIIVKPAEGVQS-T 59
+++ V+ H GSS S + T V C V GP + SRQE P + L++ + +
Sbjct: 4 IKSMVSVISHCTGSSRFSYNNTTVFCVVHGPSDAISRQEDPDRAILDVRWRDMVLINGRV 63
Query: 60 REKLMEDQIRSVLTPVLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVD 119
+K I +L+ + L + +QI V+ GE+R+ + VNAA+LAL D
Sbjct: 64 YDKYFSRVIEKILSKNIILELDACKVIQISFNVV--GETRN----TLFCAVNAALLALAD 117
Query: 120 AGVPLLSM 127
G+PL SM
Sbjct: 118 GGIPLRSM 125
>At3g46210 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subunit Rrp46
Length = 239
Score = 55.5 bits (132), Expect = 6e-08
Identities = 39/148 (26%), Positives = 66/148 (44%), Gaps = 7/148 (4%)
Query: 6 HVLGHVDGSSVVSNSGTKVICSVSGPMEPKSRQELPTQLALEIIVKPAEGVQSTREKLME 65
++L GS+ S TKV+ +V GP + E + E+I KP G EK E
Sbjct: 22 NILHRPHGSASWSQGDTKVLAAVYGPKAGTKKNENAEKACFEVIWKPKSGQIGKVEKEYE 81
Query: 66 DQIRSVLTPVLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVDAGVPLL 125
++ + + ++P + +QV+ S + +NAA ALVDAG+P+
Sbjct: 82 MILKRTIQSICVLTVNPNTTTSVIIQVVHDDGSL------LPCAINAACAALVDAGIPMK 135
Query: 126 SMCSGTCIGITTEGKQLVVNPTESQLAK 153
+ C + G LV++P + + K
Sbjct: 136 HLAVAICCCLAENG-YLVLDPNKLEEKK 162
>At3g61620 [J] KOG1068 Exosomal 3'-5' exoribonuclease complex subunit Rrp41
and related exoribonucleases
Length = 241
Score = 53.9 bits (128), Expect = 2e-07
Identities = 47/153 (30%), Positives = 66/153 (42%), Gaps = 18/153 (11%)
Query: 7 VLGHVDGSSVVSNSGTKVICSVSGPME--PKSRQELPTQLALEIIVKPAEGVQSTREKLM 64
V+ DGS+V TKVI +V GP E KS+Q+ + A+ R +
Sbjct: 28 VVSKADGSAVFEMGNTKVIAAVYGPREIQNKSQQKKNDHAVVLCEYSMAQFSTGDRRRQK 87
Query: 65 EDQ--------IRSVLTPVLARYLHPRQFVQICLQVLEA-GESRDYTVKEVSVCVNAAVL 115
D+ IR + + L P + I LQVL+A G +R S C+NAA L
Sbjct: 88 FDRRSTELSLVIRQTMEACILTELMPHSQIDIFLQVLQADGGTR-------SACINAATL 140
Query: 116 ALVDAGVPLLSMCSGTCIGITTEGKQLVVNPTE 148
AL DAG+P+ + G L +N E
Sbjct: 141 ALADAGIPMRDLAVSCSAGYLNSTPLLDLNYVE 173
>Hs9506689 [J] KOG1068 Exosomal 3'-5' exoribonuclease complex subunit Rrp41
and related exoribonucleases
Length = 245
Score = 50.8 bits (120), Expect = 1e-06
Identities = 37/129 (28%), Positives = 56/129 (42%), Gaps = 17/129 (13%)
Query: 7 VLGHVDGSSVVSNSGTKVICSVSGPMEPKSRQE--LPTQLALEIIVKPAEGVQSTREKL- 63
V DGS+ + TK + V GP E + + LP + + A R++
Sbjct: 31 VFAQADGSAYIEQGNTKALAVVYGPHEIRGSRARALPDRALVNCQYSSATFSTGERKRRP 90
Query: 64 --------MEDQIRSVLTPVLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVL 115
M Q+R + LHPR + I +QVL+A + CVNAA L
Sbjct: 91 HGDRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGT------YAACVNAATL 144
Query: 116 ALVDAGVPL 124
A++DAG+P+
Sbjct: 145 AVLDAGIPM 153
>SPAC3G9.10c [J] KOG1068 Exosomal 3'-5' exoribonuclease complex subunit Rrp41
and related exoribonucleases
Length = 242
Score = 50.1 bits (118), Expect = 3e-06
Identities = 38/149 (25%), Positives = 70/149 (46%), Gaps = 20/149 (13%)
Query: 12 DGSSVVSNSGTKVICSVSGPMEP----KSRQELPTQLALEIIVKPAEGVQSTREKLMEDQ 67
+GS+ + TKV+C V GP EP K+R + T + +EI + + +++ D+
Sbjct: 36 NGSAFIELGNTKVLCIVDGPSEPVIKSKARADR-TFVNVEINIASFSTID-VKKRFKSDR 93
Query: 68 --------IRSVLTPVLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVD 119
+++ ++ L+PR + + L VL+ + ++ C+NA LAL+D
Sbjct: 94 RIQLQCLALQNTFEEIIQTELYPRSQISVYLHVLQDDGA------VMASCINATTLALID 147
Query: 120 AGVPLLSMCSGTCIGITTEGKQLVVNPTE 148
AG+P+ + GI L +N E
Sbjct: 148 AGIPVKDFVCCSTAGIVESDMLLDLNSLE 176
>SPBC211.08c [J] KOG1068 Exosomal 3'-5' exoribonuclease complex subunit Rrp41
and related exoribonucleases
Length = 257
Score = 49.7 bits (117), Expect = 3e-06
Identities = 37/164 (22%), Positives = 73/164 (43%), Gaps = 15/164 (9%)
Query: 13 GSSVVSNSGTKVICSVSGPMEPKSRQ-ELPTQLALEIIVKPAEG------VQSTREKLME 65
GSS + K+ C+VSGP K+ +L E + P VQ+ EK
Sbjct: 50 GSSYFESEKIKIACTVSGPRPSKTFAFRSSAKLNCEFRLSPFSTSVRQGHVQTVEEKSYS 109
Query: 66 DQIRSVLTPVLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVDAGVPLL 125
I + ++P + +L+P+ + + +QV+E+ D + ++ ++ A A+ DA + +
Sbjct: 110 QMIEAAISPSILLHLYPKSSIDVYIQVIES----DGALATLAAAISCASSAIADANIDCI 165
Query: 126 SMCSGTCIGITTEGKQLVVNP----TESQLAKCESVHVYCLELG 165
+ +G+ + + ++P ++ AK V Y LG
Sbjct: 166 DLVTGSSVLFNPNTDEYWIDPDYVDERARAAKGSVVMGYMASLG 209
>YGR195w [J] KOG1068 Exosomal 3'-5' exoribonuclease complex subunit Rrp41
and related exoribonucleases
Length = 246
Score = 49.3 bits (116), Expect = 4e-06
Identities = 39/148 (26%), Positives = 67/148 (44%), Gaps = 17/148 (11%)
Query: 12 DGSSVVSNSGTKVICSVSGPMEPKSRQELPTQLAL----EIIVKPAEGVQSTREKLMEDQ 67
DGSS + K+I V GP EP+ + ++ T AL I K ++ +S E +
Sbjct: 37 DGSSYMEQGNNKIITLVKGPKEPRLKSQMDTSKALLNVSVNITKFSKFERSKSSHKNERR 96
Query: 68 IRSVLTPVLARY-------LHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVDA 120
+ + T ++ + ++PR + I + VLE +D + + +N LAL+DA
Sbjct: 97 VLEIQTSLVRMFEKNVMLNIYPRTVIDIEIHVLE----QDGGI--MGSLINGITLALIDA 150
Query: 121 GVPLLSMCSGTCIGITTEGKQLVVNPTE 148
G+ + SG +G+ L N E
Sbjct: 151 GISMFDYISGISVGLYDTTPLLDTNSLE 178
>CE02146 [J] KOG1069 Exosomal 3'-5' exoribonuclease complex subunit Rrp46
Length = 214
Score = 48.9 bits (115), Expect = 6e-06
Identities = 44/213 (20%), Positives = 95/213 (43%), Gaps = 15/213 (7%)
Query: 8 LGHVDGSSVVSNSGTKVICSVSGPMEPKSRQELPTQLALEIIVKPAEGVQSTREKLMEDQ 67
L + DGS+ S T + S SGP + + + + L+I + G + ++ +
Sbjct: 15 LKNADGSACFSQGATCIWASCSGPGDVHASKASDEAMTLDISYRANCG--DNKFNVLNNI 72
Query: 68 IRSVLTPVLARYLHPRQFVQICLQVLEAGESRDYTVKEVSVCVNAAVLALVDAGVPLLSM 127
I S L+ + L P + + + ++ S +V +N A AL+D G+P ++
Sbjct: 73 IHSTLSNAINLELFPHTTISVTVHGIQDDGSMG------AVAINGACFALLDNGMPFETV 126
Query: 128 CSGTCIGITTEGKQLVVNPTESQLAKCESVHVYCLELGTNENGDIDVRNLLLLDSLGSFD 187
G I + +L+++PT Q A ++ + G++ + ++ +D++G +D
Sbjct: 127 FCGVLIVRVKD--ELIIDPTAKQEAASTGRVLFSVCKGSDGHPEV-----CAMDAIGHWD 179
Query: 188 ESQLFKVLETGEKECIRLYTELRSVIKDKVAKD 220
QL + ++ ++V+K K++ D
Sbjct: 180 FIQLEAAWSLAQPSASAIFDFYKTVMKRKLSVD 212
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.134 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,089,890
Number of Sequences: 60738
Number of extensions: 521055
Number of successful extensions: 1356
Number of sequences better than 1.0e-05: 13
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1338
Number of HSP's gapped (non-prelim): 13
length of query: 225
length of database: 30,389,216
effective HSP length: 102
effective length of query: 123
effective length of database: 24,193,940
effective search space: 2975854620
effective search space used: 2975854620
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)