ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV3812 check: MH R KOG4347 General function prediction only GTPase-activating protein VRP
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV3812 1291872 1294703 944
(944 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGR100w [R] KOG4347 GTPase-activating protein VRP 1116 0.0
SPBC215.01 [R] KOG4347 GTPase-activating protein VRP 496 e-140
SPCC1259.11c [R] KOG4347 GTPase-activating protein VRP 357 4e-98
Hs22042713 [R] KOG4347 GTPase-activating protein VRP 246 2e-64
7296423 [R] KOG4347 GTPase-activating protein VRP 237 7e-62
Hs5902154 [R] KOG4347 GTPase-activating protein VRP 228 3e-59
CE19171 [R] KOG4347 GTPase-activating protein VRP 228 3e-59
CE18397 [R] KOG4347 GTPase-activating protein VRP 228 3e-59
Hs17485595 [R] KOG4347 GTPase-activating protein VRP 218 3e-56
Hs22056446 [U] KOG2058 Ypt/Rab GTPase activating protein 186 1e-46
At3g55020 [U] KOG2058 Ypt/Rab GTPase activating protein 162 2e-39
Hs11034851 [TR] KOG2222 Uncharacterized conserved protein contai... 162 2e-39
7299972 [TR] KOG2222 Uncharacterized conserved protein contains ... 160 9e-39
At3g07890 [U] KOG2058 Ypt/Rab GTPase activating protein 153 1e-36
Hs8922167 [U] KOG2058 Ypt/Rab GTPase activating protein 147 1e-34
CE29155 [U] KOG2058 Ypt/Rab GTPase activating protein 146 1e-34
SPAC4G8.04 [U] KOG2058 Ypt/Rab GTPase activating protein 140 7e-33
CE10236 [TR] KOG2222 Uncharacterized conserved protein contains ... 133 1e-30
YOL112w [U] KOG2058 Ypt/Rab GTPase activating protein 130 7e-30
CE08508 [U] KOG2058 Ypt/Rab GTPase activating protein 129 2e-29
Hs21361485 [U] KOG2221 PDZ-domain interacting protein EPI64 cont... 129 3e-29
Hs13994322 [U] KOG2221 PDZ-domain interacting protein EPI64 cont... 129 3e-29
At5g15930 [R] KOG1102 Rab6 GTPase activator GAPCenA and related ... 127 8e-29
At3g02460 [R] KOG1102 Rab6 GTPase activator GAPCenA and related ... 126 1e-28
YNL293w [U] KOG2058 Ypt/Rab GTPase activating protein 125 2e-28
SPCC4G3.09c [U] KOG2058 Ypt/Rab GTPase activating protein 125 3e-28
7300111 [U] KOG2058 Ypt/Rab GTPase activating protein 123 2e-27
7299471 [U] KOG2221 PDZ-domain interacting protein EPI64 contain... 122 2e-27
Hs12232373 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 122 3e-27
CE07531 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contai... 119 2e-26
Hs18590199 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (con... 119 3e-26
Hs19923325_1 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (c... 117 6e-26
Hs7661864 [R] KOG1102 Rab6 GTPase activator GAPCenA and related ... 115 3e-25
Hs13376023 [U] KOG2058 Ypt/Rab GTPase activating protein 112 2e-24
At2g37290 [U] KOG2058 Ypt/Rab GTPase activating protein 112 3e-24
7295111 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 111 6e-24
CE17203 [U] KOG2221 PDZ-domain interacting protein EPI64 contain... 108 5e-23
CE28759 [TR] KOG2223 Uncharacterized conserved protein contains ... 107 9e-23
7292646 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contai... 107 9e-23
CE28983 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 105 3e-22
7303241 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 105 3e-22
Hs7662198 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (cont... 105 4e-22
CE27154 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 105 4e-22
7296688 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contai... 105 4e-22
CE27153 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 103 1e-21
At2g39280 [U] KOG2058 Ypt/Rab GTPase activating protein 103 2e-21
Hs20532509 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (con... 102 4e-21
Hs14745035 [TR] KOG2223 Uncharacterized conserved protein contai... 100 1e-20
Hs14733591 [TR] KOG2223 Uncharacterized conserved protein contai... 99 2e-20
YPL249c [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 96 3e-19
Hs4758564_1 [R] KOG1102 Rab6 GTPase activator GAPCenA and relate... 91 8e-18
Hs22062568 [U] KOG2221 PDZ-domain interacting protein EPI64 cont... 91 1e-17
Hs14149985 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 86 4e-16
Hs22066444 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 84 8e-16
ECU11g1700 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 84 1e-15
Hs20560763 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 80 1e-14
SPAC26F1.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and relate... 80 2e-14
Hs18580214 [U] KOG2058 Ypt/Rab GTPase activating protein 75 5e-13
7299317 [U] KOG2058 Ypt/Rab GTPase activating protein 73 2e-12
Hs22058425 [U] KOG2058 Ypt/Rab GTPase activating protein 71 9e-12
SPAC23D3.03c [TR] KOG2223 Uncharacterized conserved protein cont... 66 3e-10
Hs14916463 [R] KOG1093 Predicted protein kinase (contains TBC an... 64 8e-10
7290543 [R] KOG1093 Predicted protein kinase (contains TBC and R... 60 1e-08
SPBC1778.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and relate... 59 4e-08
Hs20562247 [U] KOG2801 Probable Rab-GAPs 57 2e-07
7295589_1 [R] KOG1648 Uncharacterized conserved protein contains... 55 7e-07
YMR192w [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 54 1e-06
Hs13375952 [T] KOG2197 Ypt/Rab-specific GTPase-activating protei... 52 3e-06
>YGR100w [R] KOG4347 GTPase-activating protein VRP
Length = 950
Score = 1116 bits (2887), Expect = 0.0
Identities = 557/957 (58%), Positives = 719/957 (74%), Gaps = 22/957 (2%)
Query: 1 MSFFDTLRNTANSVKEKFADNSSPKLTRDERFRLDYKLPSTEYILDDTSAEISMLSPYKN 60
MSFFD+LR A + +K AD+ +P LTRDE+FRL YKLP+ E IL+DT+AE+S + K+
Sbjct: 1 MSFFDSLRQKAPFL-DKLADSFTPTLTRDEKFRLKYKLPANENILEDTNAEVSFATSIKD 59
Query: 61 VNRKSATSREKPVENTYVYSGRLFLTPHFLVFRDSFDHMSCVMVLNISTIKRVERANIAS 120
S K + YVYSGRLFLTPHFLVFRD+FDH SCV++LNISTIKRVER+ S
Sbjct: 60 GKGHSDRVNNKGRKTAYVYSGRLFLTPHFLVFRDAFDHSSCVLILNISTIKRVERSPSES 119
Query: 121 YAFSLQVTLLSGARLIIQFIGLRYRSEEFSHKLKMQLRDNIPQTKNMPAFLGTLYSEYII 180
Y F+L VTL +GA+++IQFIG+RYRSE+F KLK+ L++NIP K +PAFL T YSE++I
Sbjct: 120 YEFALLVTLYTGAKVLIQFIGIRYRSEQFCDKLKLNLKENIPNAKTLPAFLETSYSEFLI 179
Query: 181 EKNIDKNRELQPPSLGLGQIYKYPGDPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYK 240
KNI +++ P GLGQ +KYPG+P + KEKAKLRLWF+YF+ NG NL++++ P F K
Sbjct: 180 AKNILGKKDITVPRAGLGQHFKYPGNPTMVKEKAKLRLWFDYFRENGRNLAVVQTPMFRK 239
Query: 241 LIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPD 300
LIR+G+PNR+RGEIWELCSG+MY R+ N Y+++L ++ G+ SQAI+EIEKDL RSLP+
Sbjct: 240 LIRIGVPNRMRGEIWELCSGAMYMRYANSGEYERILNENAGKTSQAIDEIEKDLKRSLPE 299
Query: 301 YAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLY 360
Y+AYQ EGI +LRNVL AYSWKNPDVGYCQAMNIVVA LIFMSEEQAFW LCNLCD+Y
Sbjct: 300 YSAYQTEEGIQRLRNVLTAYSWKNPDVGYCQAMNIVVAGFLIFMSEEQAFWCLCNLCDIY 359
Query: 361 VPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQ 420
VPGYYSKTMYGTLLDQRVFESFVE +MPV+W +I ++DIQLSVVSLPWFLSLFF +MPL+
Sbjct: 360 VPGYYSKTMYGTLLDQRVFESFVEDRMPVLWEYILQHDIQLSVVSLPWFLSLFFTSMPLE 419
Query: 421 FAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSAHPES 480
+A RIMDIFF+NG TLFQVALA+LK+NADD+L+ DDDGMFIAI+K YFQ L SAHP+S
Sbjct: 420 YAVRIMDIFFMNGSITLFQVALAVLKINADDILQADDDGMFIAIIKHYFQTLGQSAHPDS 479
Query: 481 SDVKYRQITKFQELLVVAFKEFDIITEELVETERNKYKKGILHDIESFAKRTQLRNVSKA 540
SD+KYRQITKFQELLV AFKEF +I+EE+ R+KY+KGI +IE+F KRTQLR++ K
Sbjct: 480 SDIKYRQITKFQELLVTAFKEFSVISEEMAMHARHKYEKGIFQNIETFMKRTQLRHMPKT 539
Query: 541 VHLSQNEVXXXXXXXXXXXXXXXXXMGTGSSKMDFTSFVQFLAKICDWCKSSSSDLDHRF 600
+LS +++ MGTGSS M F F+QFL+K CD C+ D D F
Sbjct: 540 FNLSSDDLSNIYDMFYQSIETYKISMGTGSSNMGFEVFIQFLSKFCDSCRPCEKDKDPAF 599
Query: 601 RKQRNDFLKRLFKSWDKGNFGELTLNDVVSGLDKMKTEDIMESMNNFFQLYDDQQTGKIQ 660
RKQ+ +FL+RLF +WD + GELTLNDVV+GLDK+ T D+++++N FF LYD G++
Sbjct: 600 RKQKRNFLQRLFDNWDSAHIGELTLNDVVTGLDKLVTVDLLQAINYFFSLYDTDGDGELH 659
Query: 661 REQILKMSEDLLFLTEPWKSGRCIDLLTQTSIENDIAESIVKKNGGRVVTLEEIELPKGV 720
RE++L++SE LL LTEPWKSGR +DLLT+ IE+DIAE+I+K++GG + T+ +IELP GV
Sbjct: 660 REEVLQLSEGLLLLTEPWKSGRYVDLLTKKRIEDDIAENIIKESGGEIATMNQIELPTGV 719
Query: 721 VIDDEKYKAEQSERYLHAASNFLQRCFEYAQPLEQEVPIDLLDLSDDTDXXXXXXXXXXR 780
ID+EKYK EQ+ERYL AASNFLQR FEYA+ ++ ++L+DLSDD + +
Sbjct: 720 TIDEEKYKVEQAERYLKAASNFLQRSFEYAKAVDLAEEVNLIDLSDD-EGEEKRTVKQKQ 778
Query: 781 WNSLKANVALNPNTPCTLDLATFRMLVLADETYEQFFANTLRNSIHVDEQVNALESRSKA 840
S+KAN AL+P P +DL TFRM++LADETYE FF+NTLR+S+HVDE VN +++++K
Sbjct: 779 LESIKANAALDPTHPKVIDLPTFRMIILADETYELFFSNTLRSSVHVDEHVN-IDNKNKV 837
Query: 841 LRNVFDGLIADGRRVANQVRRRVDSVATQQS-----ESPS---------QDKQIDLDDFS 886
LR++FDG++ADG+RVA QVRRRVDSVAT+ S +P+ ++K DLDDF+
Sbjct: 838 LRSMFDGILADGKRVAEQVRRRVDSVATRSSIASVESTPTAAASSITTKEEKYDDLDDFT 897
Query: 887 TDHGDESMELLXXXXXXXXXXXXXXXXXXXKKLNSFDLDQSTHPDNHQGKKDLIEFE 943
++H E+ ELL ++ SF + ++ + K +LIEFE
Sbjct: 898 SEHQPENEELLQSSWFEIDDANETSTKAIQER--SF---EPLSANSSEEKSNLIEFE 949
>SPBC215.01 [R] KOG4347 GTPase-activating protein VRP
Length = 827
Score = 496 bits (1278), Expect = e-140
Identities = 305/804 (37%), Positives = 434/804 (53%), Gaps = 103/804 (12%)
Query: 73 VENTYVYSGRLFLTPHFLVFR-DSFDHMSCVMVLNISTIKRVER-----------ANIAS 120
+E+ ++G L+L ++ F+ D + C+ I + RV+ +N
Sbjct: 52 LEDPNSFNGLLYLFTDYIAFQGDDESNQFCMPYTIIRKVSRVKSNDLEQLLSVSTSNGYE 111
Query: 121 YAFSLQVTLLSGARLIIQFIGLRYRSEEFSHKLKMQLRDNIPQTKNMPAFLGTLYSEYII 180
Y SLQV+ + A Q + R E SHK MQ F +SE +
Sbjct: 112 YRISLQVSETTAAHFC-QLL----REELVSHKADMQRSSE---------FSKQFFSERLC 157
Query: 181 EKNIDKNRELQPPSLGLGQIYKYPGDPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYK 240
+ N+ + S G G Y YP DP + +E+AKLR+W EYF G NLSL+R F K
Sbjct: 158 KPNVPEPETKD--SYGFGARYGYPTDPRISRERAKLRMWKEYFLLYGANLSLIRVSLFSK 215
Query: 241 LIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPD 300
L+R+ +PN+LRGEIWEL SGSMY R N D Y LL+ + G+ S ++EEIEKDL RSLP+
Sbjct: 216 LVRIELPNKLRGEIWELTSGSMYFRLENSDEYDHLLKVYSGQTSFSLEEIEKDLGRSLPE 275
Query: 301 YAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLY 360
Y AYQ+ EGI+ LRNVLVA+SWKN +VGYCQAMNIV A LLI +EEQ F+ + +C+ Y
Sbjct: 276 YPAYQNEEGINALRNVLVAFSWKNQEVGYCQAMNIVAAALLIHCTEEQTFFLMHKICEDY 335
Query: 361 VPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQ 420
+PGYYSKTMYGTL+DQ+V+ES V+ MP + H DIQLS++SLPWFLSLF MPL
Sbjct: 336 IPGYYSKTMYGTLIDQQVYESLVQRSMPNLHAHFVSKDIQLSIISLPWFLSLFLCTMPLP 395
Query: 421 FAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSAHPES 480
+AFR++D FF+ GP+ LFQ+ +AIL N ++++ +D M I+ILK+YF L D A+ ++
Sbjct: 396 YAFRLLDFFFLEGPRVLFQIGMAILYDNEAEIMKATEDTMLISILKNYFSSLGDKAYKDA 455
Query: 481 SDVKYRQITKFQELLVVAFKEFDIITEELVETERNKYKKGILHDIESFAKRTQLRNVSKA 540
+D + ITKFQ LLV AFK+F IT L+E ER K+ +G+++ IESFAKRTQ+R++
Sbjct: 456 TDKRVASITKFQLLLVTAFKKFSHITHSLIEDERKKHYEGVMNSIESFAKRTQIRSLQNY 515
Query: 541 VHLSQNEVXXXXXXXXXXXXXXXXXMGTGSS---KMDFTSFVQFLAKICDWCKSSSSDLD 597
L++ ++ +G GSS +++F F FLA + +W K LD
Sbjct: 516 GTLTRTDL-SNIYDRYHEVLSSKHRVGLGSSTDTRLEFDEFCIFLAGVTEWAKG----LD 570
Query: 598 HRFRKQRNDFLKRLFKSWDKGNFGELTLNDVVSGLDKMKTEDIMESMNNFFQLYDDQQTG 657
+ FL+ LF +DK G L+L D+VSG+ ++K D+M +++ F+LYD G
Sbjct: 571 AAAINNSSSFLRHLFLRFDKSMTGSLSLQDLVSGIAELKFRDVMRNISFIFELYDFNGDG 630
Query: 658 KIQREQILKMSEDLLFLTEPWKSGRCIDLLTQTSIENDIAESIVKKNGGRVVTLEEIELP 717
+ + +LK+SE +L+LT
Sbjct: 631 FMDKPDVLKVSEAILWLTR----------------------------------------- 649
Query: 718 KGVVIDDEKYKAEQSERYLHAASNFLQRCFEYAQPLEQEVPID-LLDLSDDTDXXXXXXX 776
+ DE A S F+QRCF +A + D L+D+SD
Sbjct: 650 ---FMGDEYLSA---------VSEFIQRCFHFADEASPDGHSDTLIDISDHMSSTG---- 693
Query: 777 XXXRWNSLKANVALNPNTPCTLDLATFRMLVLADETYEQFFANTLRNSIHVDEQVNALES 836
N ++ N+ + L TFRM+VL+ EQ F+ L +SI V V S
Sbjct: 694 --------SENRSVGANSDIKVSLPTFRMVVLSIGLLEQLFSGGLADSI-VLAPVQEKSS 744
Query: 837 RSKALRNVFDGLIADGRRVANQVR 860
+ LR + D L+ D R+ R
Sbjct: 745 TTGGLRGLLDSLVIDTNRIGKTFR 768
>SPCC1259.11c [R] KOG4347 GTPase-activating protein VRP
Length = 720
Score = 357 bits (917), Expect = 4e-98
Identities = 209/648 (32%), Positives = 339/648 (52%), Gaps = 22/648 (3%)
Query: 43 YILDDTSAEISMLSP--YKNVNRKSATSREKPVENTYVYS---GRLFLTPHFLVFRDSFD 97
++ DD A L P + +N++ E + YS G ++ FL F D
Sbjct: 8 FLEDDYDAYEGTLDPASFFRINKQEEIIASTVCEIGWEYSKSFGNAYICTSFLCFHS--D 65
Query: 98 HMSCVMVLNISTIKRVERANIASYAFSLQVTLLSGARLIIQFIGLRYRSEEFSHKLKMQL 157
++ ++++ER N + F+ ++ + ++F G R +SE F +L QL
Sbjct: 66 DFKTRFTFPLAAVRKLERENSDNDTFTFDLSNFHSQIIHLRFKGTRQQSEFFCDRLVRQL 125
Query: 158 RDNIPQTKNMPAFLGTLYSEYIIEKNIDKNRELQPPSLGLGQIYKYP-----GDPALQKE 212
++ ++ FL +L SE + ++E++ LGLG + YP + + +
Sbjct: 126 HASLEDASSVGLFLLSLASERVCFSESANSQEIESIDLGLGSQFGYPIASSNTNGLINEN 185
Query: 213 KAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYERFMNKDLY 272
+K W +Y K NG N +L++ P F KL++ GIPN LR +IWE CSGS++ R+ +K Y
Sbjct: 186 NSKS--WIQYLKKNGANFNLIQTPNFQKLVQSGIPNNLRADIWETCSGSLFPRWKSKGFY 243
Query: 273 QKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQA 332
K ++ + EEIEKDL RSLPDY AYQ P GI+ LR +L+ YS N +VGYCQA
Sbjct: 244 AKNIDSVINNRCEYSEEIEKDLTRSLPDYPAYQSPTGINTLRRILLFYSETNKEVGYCQA 303
Query: 333 MNIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWN 392
MNIV+A LL++ +EEQA++ LC+ Y+PGYY+K ++G LLD VFE +E +P ++
Sbjct: 304 MNIVLAALLVYCTEEQAYFLFSQLCEFYIPGYYAKIIHGLLLDLTVFEYVLEHTLPHLYQ 363
Query: 393 HIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDL 452
I + D+ L ++++ WF SLF L +AFRI+D FVNGP+ LFQVALA+ KVNA +
Sbjct: 364 KIIELDMDLKLITINWFFSLFIKDFRLDYAFRILDCLFVNGPRVLFQVALALFKVNAQGI 423
Query: 453 LEVDDDGMFIAILKSYFQRLDDSAHPESSDV---KYRQITKFQELLVVAFKEFDIITEEL 509
L DD + + + F ++ + + +L VAF+ FD IT+
Sbjct: 424 LNATDDSSVMKVFRQCFDHINQGTAADEKMAALGSRSSMCTLPQLFAVAFEYFDFITDSF 483
Query: 510 VETERNKYKKGILHDIESFAKRTQLRNVSKAVHLSQNEVXXXXXXXXXXXXXXXXXMG-T 568
V +R ++K +L+ + F KR+ LR+V + LS ++ G
Sbjct: 484 VSAKRKEFKSSVLYSLRCFTKRSHLRSVYQTTLLSNTDLDLVYDAFINAIGENNICHGDV 543
Query: 569 GSSKMDFTSFVQFLAKICDWCKSSSSDLDHRFRKQRNDFLKRLFKSWDKGNFGE--LTLN 626
K+DF F + + C S +++ + RL+ G+ E LT
Sbjct: 544 LEQKIDFNGFERLVD--CAAPPLSVIREPLHYQRSKRKLFTRLYIWMKDGDSTETSLTFK 601
Query: 627 DVVSGLDKMKTEDIMESMNNFFQLYDDQQTGKIQREQILKMSEDLLFL 674
++ GL+++K + + S FQLYD ++ G ++ E+++++SE L+ L
Sbjct: 602 RIIHGLERLKADIALHSEILCFQLYDLKRDGTLRTEEVVELSESLILL 649
>Hs22042713 [R] KOG4347 GTPase-activating protein VRP
Length = 1266
Score = 246 bits (627), Expect = 2e-64
Identities = 178/676 (26%), Positives = 320/676 (47%), Gaps = 84/676 (12%)
Query: 28 RDERFRLDYKLPSTEYILDDTSAEISMLSPYKNVNRKSATSREKPVENTYVYSGRLFLTP 87
+ ER+R ++LP E + D + ++ +P+ ++ G++F++
Sbjct: 291 KSERYRALFRLPKDEKL--DGHTDCTLWTPFNKMH----------------ILGQMFVST 332
Query: 88 HFLVFRDSFDHMSCVMVLNISTIKRVERANIASYAFSLQVTLLSGARLIIQFIGLRYR-- 145
+++ F +++ C +++ + + VE+A+ +S S +++ + R+ F L+ R
Sbjct: 333 NYICFTSKEENL-CSLIIPLREVTIVEKADSSSVLPS-PLSISTRNRMTFLFANLKDRDF 390
Query: 146 -------------SEEFSHK-LKMQLRDNIPQTKNMPAFLGTLYSEYIIEKNIDKNRELQ 191
S+ +S K + + + P+ L + + + D R+
Sbjct: 391 LVQRISDFLQQTTSKIYSDKEFAGSYNSSDDEVYSRPSSLVSSSPQRSTSSDADGERQFN 450
Query: 192 -------PPSLGLGQIYKYPG----DPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYK 240
+ L +Y+ +P L KE K + W +F G + + R +
Sbjct: 451 LNGNSVPTATQTLMTMYRRRSPEEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRE 510
Query: 241 LIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPD 300
L+ GIP +RGE+W L SG++ E+ + Y+ L+E G+ + A EEIE+DL+RSLP+
Sbjct: 511 LVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPE 570
Query: 301 YAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLY 360
+ A+Q+ GI LR VL AY+++NP++GYCQAMNIV +VLL++ EE+AFW L LC+
Sbjct: 571 HPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERM 630
Query: 361 VPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQ 420
+P YY+ + G L+DQ VFE +P +++ + + +S +SL WFL+LF MP +
Sbjct: 631 LPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGV-ISTISLSWFLTLFLSVMPFE 689
Query: 421 FAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRL--DDSAHP 478
A ++D FF G K +FQ+ALA+L N D LL DDG + +L Y + DS P
Sbjct: 690 SAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLP 749
Query: 479 E--------SSDVK-YRQITKFQELLVVAFKEFDIITEELVETERNKYKKGILHDIESFA 529
S DV+ Y ++ F+ L+ ++++F I +L+E R K + ++ +E
Sbjct: 750 PIPHLHSLLSDDVEPYPEVDIFR-LIRTSYEKFGTIRADLIEQMRFKQRLKVIQTLEDTT 808
Query: 530 KRTQLRNVSKAVHLSQNEVXXXXXXXXXXXXXXXXXMGTGSS--------------KMDF 575
KR +R + + +E+ G+ ++ ++DF
Sbjct: 809 KRNVVRTIVTETSFTIDELEELYALFKAEHLTSCYWGGSSNALDRHDPSLPYLEQYRIDF 868
Query: 576 TSFVQFLAKICDWCKSSSSDLDHRFRKQRNDFLKRLFKSWDKGNFGELTLNDVVSGLDKM 635
F A + W + SD+ RLF+ D+ + + VSGL
Sbjct: 869 EQFKGMFALLFPWACGTHSDV----------LASRLFQLLDENGDSLINFREFVSGLSAA 918
Query: 636 KTEDIMESMNNFFQLY 651
D+ E + ++++
Sbjct: 919 CHGDLTEKLKLLYKMH 934
>7296423 [R] KOG4347 GTPase-activating protein VRP
Length = 1291
Score = 237 bits (604), Expect = 7e-62
Identities = 159/556 (28%), Positives = 285/556 (50%), Gaps = 53/556 (9%)
Query: 9 NTANSVKEKFADNSSPKLTRD-------ERFRLDYKLPSTEYILDDTSAEISMLSPY-KN 60
+T+N + + P L RD E FR+ ++LP +E I D + ++ +PY K
Sbjct: 254 DTSNFSRLGSKTSKKPVLLRDLTARQKSEEFRIYFRLPQSEII--DGKIKANIWTPYSKR 311
Query: 61 VNRKSATSREKPVENTYVYSGRLFLTPHFLVFRDSFDHMSCVMVLNISTIKRVERANIAS 120
N SG ++L+P+F FR + V V+ + TIK VE+ +
Sbjct: 312 FN-----------------SGFIYLSPNFFCFRSDVKDLVSV-VIPMKTIKSVEKKDDGQ 353
Query: 121 YAFSLQVTLLSGARLIIQFIGLRYRSEEFSHKLKMQLRDNIPQTKNMPAFLGTLYSEYII 180
F Q+ +++ + F + R+ S + R ++P ++ + +S+
Sbjct: 354 QRFENQIVIITSENVPFMFAHIVDRAVLISKITDLLARVHVPLSRERAKY-DISWSKQTA 412
Query: 181 EKNIDKNRELQPPSLGLGQIYKYPGDPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYK 240
N K + +QK++ K+ W +F+ G + + R
Sbjct: 413 LMNTFKTQF---------------SAEIIQKQEEKMVRWEAHFRDFGRGIGMFRTTDVIN 457
Query: 241 LIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKG-ENSQAIEEIEKDLNRSLP 299
LI GIP++LR EIW + SG+++++ MN LY+ L+E +N A +EI++DL RSLP
Sbjct: 458 LIVEGIPDKLRQEIWLIFSGAIHDKEMNPGLYEDLVEKAACIKNCFAHDEIDRDLPRSLP 517
Query: 300 DYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDL 359
++ A+Q +GI LR VL AY+ +NP VGYCQAMNIV +V L+F EE AFW L +LC+
Sbjct: 518 EHPAFQSTDGIGALRRVLQAYALRNPQVGYCQAMNIVSSVFLLFCDEENAFWMLASLCEN 577
Query: 360 YVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPL 419
+P YY + G +DQ V VE+ +P + H+ + + + ++S+ WFL++F +
Sbjct: 578 LLPDYYKDKVVGAQIDQGVLNELVETHLPDLHGHLEQLGV-IKMISISWFLTIFMSVISY 636
Query: 420 QFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSAH-- 477
+ + I+D FF G K +F ++L I++ N D LL DDG + +L++Y + + + +
Sbjct: 637 ESSLHILDCFFYEGAKIIFMISLQIIEWNRDKLLICQDDGEAMLVLQNYLEGVYNPEYQV 696
Query: 478 PESSDVKYR----QITKFQELLVVAFKEF-DIITEELVETERNKYKKGILHDIESFAKRT 532
P ++D + Q Q L+ A+ +F + IT++ +E RNK+++ + + ++T
Sbjct: 697 PPTTDKRKMERKVQTQTVQTLIHEAYTKFGEDITQQRIEELRNKHRRLTMRQFDIDNEKT 756
Query: 533 QLRNVSKAVHLSQNEV 548
++ + + +++E+
Sbjct: 757 IVKAYVQNPYFNRSEL 772
>Hs5902154 [R] KOG4347 GTPase-activating protein VRP
Length = 897
Score = 228 bits (582), Expect = 3e-59
Identities = 160/552 (28%), Positives = 270/552 (47%), Gaps = 58/552 (10%)
Query: 28 RDERFRLDYKLPSTEYILDDTSAEISMLSPYKNVNRKSATSREKPVENTYVYSGRLFLTP 87
++E FR ++LP E + + S+ +P+ + +GR+F +
Sbjct: 40 QNEFFRAFFRLPRKEKL--HAVVDCSLWTPFSRCHT----------------AGRMFASD 81
Query: 88 HFLVFRDSFDHMSCVMVLNISTIKRVERANIASYAFSLQVTLLSGARLIIQFIGLRYRS- 146
++ F D C ++L + + +E+ S + + +++ QFI LR R
Sbjct: 82 SYICFASREDGC-CKIILPLREVVSIEKMEDTSL-LPHPIIVSIRSKVAFQFIELRDRDS 139
Query: 147 --EEFSHKLKMQLRDNIPQTKNMPAF---------------------LGTLYSEYIIEKN 183
E +LK Q+ N P + A L + S+ E
Sbjct: 140 LVEALLARLK-QVHANHPVHYDTSADDDMASLVFHSTSMCSDHRFGDLEMMSSQNSEESE 198
Query: 184 IDKNRELQPPSL--GLGQIYKYPGDPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYKL 241
+K+ + P +L Q D + +E+ K+ LW ++F G + + R KL
Sbjct: 199 KEKSPLMHPDALVTAFQQSGSQSPDSRMSREQIKISLWNDHFVEYGRTVCMFRTEKIRKL 258
Query: 242 IRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDY 301
+ +GIP LRG +W L S ++ + + Y L+E+ G+ EEIE+DL+RSLP++
Sbjct: 259 VAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPEH 318
Query: 302 AAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLYV 361
A+Q+ GI LR VL AY+ +NP +GYCQ+MNI+ +VLL++ EE+AFW L +C+ +
Sbjct: 319 PAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVCERML 378
Query: 362 PGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQF 421
P Y++ + G +DQ VFE ++ +P + H+ L+ VSL WFL+LF MPL+
Sbjct: 379 PDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLS-ALASVSLSWFLTLFLSIMPLES 437
Query: 422 AFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRL--DDSAHPE 479
A ++D FF +G K +FQ+ LA+L+ NA+DL DDG + IL + + +DS P
Sbjct: 438 AVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILSRFLDHIKNEDSPGPP 497
Query: 480 --------SSDVKYRQITKFQELLVVAFKEFDIITEELVETERNKYKKGILHDIESFAKR 531
S D + +T +L+ ++++F + E +E R K++ +L E K+
Sbjct: 498 VGSHHAFFSDDQEPYPVTDISDLIRDSYEKFGDQSVEQIEHLRYKHRIRVLQGHEDTTKQ 557
Query: 532 TQLRNVSKAVHL 543
LR V V +
Sbjct: 558 NVLRVVIPEVSI 569
>CE19171 [R] KOG4347 GTPase-activating protein VRP
Length = 1270
Score = 228 bits (581), Expect = 3e-59
Identities = 180/665 (27%), Positives = 298/665 (44%), Gaps = 69/665 (10%)
Query: 28 RDERFRLDYKLPSTEYILDDTSAEISMLSPYKNVNRKSATSREKPVENTYVYSGRLFLTP 87
R + FR + LP TE + DT + +PY R P G+LF++
Sbjct: 319 RSDAFRCQFNLPLTEKLDGDTQCRL--FTPYDR--------RHVP--------GKLFVSA 360
Query: 88 HFLVFRDSFDHMSCVMVLNISTIKRVERANIASYAFSLQVTLLSGARLIIQFIGLRYRSE 147
+F+ F + + ++V I E + ++S + + L + F + R
Sbjct: 361 NFVCFASRTERLVSIVVPLIEVTSIEECSPVSSSQTTQGILLCLRNDATVIFSAVPDRDR 420
Query: 148 EFSHKLKMQLRDNIPQTKNMPAFLGTLYSEYIIEKNIDKNRELQPPSLGLGQIYKYP-GD 206
S R I +T SE + I KYP G
Sbjct: 421 VLSKITVFLERGKIERTMEK----AKADSERGRSSTSSSSSSFDKLIWDCPLIEKYPFGA 476
Query: 207 PALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYERF 266
A K + K W +Y + G + + R ++L+ G+P +LRG+IW +CSG+ E
Sbjct: 477 DASDKCREK---WNKYLQEYGTGVCMYRTVELHRLLLEGVPLQLRGQIWMVCSGAAAEMA 533
Query: 267 MNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDKLRNVLVAYSWKNPD 326
+N Y++LL ++G S A+EEIE+DL+RSLP++ A+Q GID LR +L AY+++NP+
Sbjct: 534 LNPGYYRELLHKNQGVYSVALEEIERDLHRSLPEHPAFQQGPGIDALRRILTAYAFRNPN 593
Query: 327 VGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFVESK 386
+GYCQAMNIV +VLL+F EE+AFW L +C+ +P YY+ + G L+DQ VF VE
Sbjct: 594 IGYCQAMNIVGSVLLLFTKEEEAFWLLVAVCERLLPDYYNTKVVGALVDQGVFSELVERL 653
Query: 387 MPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILK 446
+P + + + + +V+L WFL++F A+ A RI+D+FF G + +FQVAL +LK
Sbjct: 654 LPTVGAQLTRLGLD-DMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLMFQVALEMLK 712
Query: 447 VNADDLLEVDDDGMFIAILKSYFQR---------------------LDDSAHPESSDVKY 485
N + E DDG + L Y + L D S+ + +
Sbjct: 713 ENEKLICESRDDGEILMSLAKYTESIYEGDTVVERKPSTVQLGTTILSDLEEAASTMINF 772
Query: 486 --RQITK------FQELLVVAFKEFD-IITEELVETERNKYKKGILHDIESFAKRTQLRN 536
IT+ +LL +++ F T E +ET R K + ++ ++E R+ +++
Sbjct: 773 MGTDITRTFPKIPIGDLLANSYQNFGYCFTNENIETLRLKNRLKVVQNLEDNQMRSIIKS 832
Query: 537 VSKAVHLSQNEVXXXXXXXXXXXXXXXXXMGTGSSKMDFTSFVQFLAKICDWCKSSSSDL 596
+ K + E+ S++ + + D C S L
Sbjct: 833 IGKDCRFTNEELEALYNVVKEEHLLSWRHRLGVSARGKMAAVTE--RPRPDPCAQSQYRL 890
Query: 597 DHRFRKQ----------RNDFLKRLFKSWDKGNFGELTLNDVVSGLDKMKTEDIMESMNN 646
D+ + N F+ R+F+ D + G LT D+ L + + E +
Sbjct: 891 DYDLFSEVFPRLLPWPVTNIFIIRVFRLLDISDNGLLTFRDLAINLSILLRGEATEKLAL 950
Query: 647 FFQLY 651
F++ +
Sbjct: 951 FYKCH 955
>CE18397 [R] KOG4347 GTPase-activating protein VRP
Length = 1268
Score = 228 bits (581), Expect = 3e-59
Identities = 180/665 (27%), Positives = 298/665 (44%), Gaps = 69/665 (10%)
Query: 28 RDERFRLDYKLPSTEYILDDTSAEISMLSPYKNVNRKSATSREKPVENTYVYSGRLFLTP 87
R + FR + LP TE + DT + +PY R P G+LF++
Sbjct: 319 RSDAFRCQFNLPLTEKLDGDTQCRL--FTPYDR--------RHVP--------GKLFVSA 360
Query: 88 HFLVFRDSFDHMSCVMVLNISTIKRVERANIASYAFSLQVTLLSGARLIIQFIGLRYRSE 147
+F+ F + + ++V I E + ++S + + L + F + R
Sbjct: 361 NFVCFASRTERLVSIVVPLIEVTSIEECSPVSSSQTTQGILLCLRNDATVIFSAVPDRDR 420
Query: 148 EFSHKLKMQLRDNIPQTKNMPAFLGTLYSEYIIEKNIDKNRELQPPSLGLGQIYKYP-GD 206
S R I +T SE + I KYP G
Sbjct: 421 VLSKITVFLERGKIERTMEK----AKADSERGRSSTSSSSSSFDKLIWDCPLIEKYPFGA 476
Query: 207 PALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYERF 266
A K + K W +Y + G + + R ++L+ G+P +LRG+IW +CSG+ E
Sbjct: 477 DASDKCREK---WNKYLQEYGTGVCMYRTVELHRLLLEGVPLQLRGQIWMVCSGAAAEMA 533
Query: 267 MNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDKLRNVLVAYSWKNPD 326
+N Y++LL ++G S A+EEIE+DL+RSLP++ A+Q GID LR +L AY+++NP+
Sbjct: 534 LNPGYYRELLHKNQGVYSVALEEIERDLHRSLPEHPAFQQGPGIDALRRILTAYAFRNPN 593
Query: 327 VGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFVESK 386
+GYCQAMNIV +VLL+F EE+AFW L +C+ +P YY+ + G L+DQ VF VE
Sbjct: 594 IGYCQAMNIVGSVLLLFTKEEEAFWLLVAVCERLLPDYYNTKVVGALVDQGVFSELVERL 653
Query: 387 MPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILK 446
+P + + + + +V+L WFL++F A+ A RI+D+FF G + +FQVAL +LK
Sbjct: 654 LPTVGAQLTRLGLD-DMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLMFQVALEMLK 712
Query: 447 VNADDLLEVDDDGMFIAILKSYFQR---------------------LDDSAHPESSDVKY 485
N + E DDG + L Y + L D S+ + +
Sbjct: 713 ENEKLICESRDDGEILMSLAKYTESIYEGDTVVERKPSTVQLGTTILSDLEEAASTMINF 772
Query: 486 --RQITK------FQELLVVAFKEFD-IITEELVETERNKYKKGILHDIESFAKRTQLRN 536
IT+ +LL +++ F T E +ET R K + ++ ++E R+ +++
Sbjct: 773 MGTDITRTFPKIPIGDLLANSYQNFGYCFTNENIETLRLKNRLKVVQNLEDNQMRSIIKS 832
Query: 537 VSKAVHLSQNEVXXXXXXXXXXXXXXXXXMGTGSSKMDFTSFVQFLAKICDWCKSSSSDL 596
+ K + E+ S++ + + D C S L
Sbjct: 833 IGKDCRFTNEELEALYNVVKEEHLLSWRHRLGVSARGKMAAVTE--RPRPDPCAQSQYRL 890
Query: 597 DHRFRKQ----------RNDFLKRLFKSWDKGNFGELTLNDVVSGLDKMKTEDIMESMNN 646
D+ + N F+ R+F+ D + G LT D+ L + + E +
Sbjct: 891 DYDLFSEVFPRLLPWPVTNIFIIRVFRLLDISDNGLLTFRDLAINLSILLRGEATEKLAL 950
Query: 647 FFQLY 651
F++ +
Sbjct: 951 FYKCH 955
>Hs17485595 [R] KOG4347 GTPase-activating protein VRP
Length = 796
Score = 218 bits (556), Expect = 3e-56
Identities = 120/324 (37%), Positives = 178/324 (54%), Gaps = 6/324 (1%)
Query: 211 KEKAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYERFMNKD 270
KEK K + W F G +S+ R L+ GIP LRGE+W L SG++ + N D
Sbjct: 453 KEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPD 512
Query: 271 LYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYC 330
Y +++E G + A EEIE+DL RSLP++ A+Q GI LR VL AY+++NP +GYC
Sbjct: 513 YYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYC 572
Query: 331 QAMNIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFVESKMPVM 390
QAMNI+ +VLL++ EE+AFW L +C+ +P Y+++ + G L+DQ VFE + +P +
Sbjct: 573 QAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQL 632
Query: 391 WNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNAD 450
H+ S VSL WFL+LF +P++ A ++D FF +G K + Q+ LAIL N D
Sbjct: 633 TEHMTDMTF-FSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLD 691
Query: 451 DLLEVDDDGMFIAILKSYFQRLDDSAHPESSDVKYRQITKFQELLVVAFKEFDIITEELV 510
LL DD + L +F + + P S+V+ ++ + DI +L+
Sbjct: 692 KLLTCKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEK---TSHTRVDI--TDLI 746
Query: 511 ETERNKYKKGILHDIESFAKRTQL 534
KY DI S R +L
Sbjct: 747 RESNEKYGNIRYEDIHSMRCRNRL 770
>Hs22056446 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 788
Score = 186 bits (473), Expect = 1e-46
Identities = 94/275 (34%), Positives = 159/275 (57%), Gaps = 7/275 (2%)
Query: 219 WFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYERFMNKDL---YQKL 275
W YF S +N ++ P LIR GIP+ R ++W+ C +F + +Q L
Sbjct: 511 WENYFAST-VNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTL 569
Query: 276 LEDHKGENSQAIEEIEKDLNRSLPDYAAYQDP--EGIDKLRNVLVAYSWKNPDVGYCQAM 333
L+ + + A ++IE DL R+LP+ Y P EGI KLRNVL+A+SW+NPD+GYCQ +
Sbjct: 570 LQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGL 629
Query: 334 NIVVAVLLIFMSEEQAFWSLCNLCDLYVP-GYYSKTMYGTLLDQRVFESFVESKMPVMWN 392
N +VAV L+++ +E AFW L + ++++P YY+KT+ G+ +DQRVF + K+P +
Sbjct: 630 NRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHG 689
Query: 393 HIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDL 452
H +Y + ++++ WFL +F ++ F+I D F GPK +F+ ALA+ K +++
Sbjct: 690 HFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEI 749
Query: 453 LEVDDDGMFIAILKSYFQRLDDSAHPESSDVKYRQ 487
L++ D L+ + + + D+ + +R+
Sbjct: 750 LKLQDSMSIFKYLRYFTRTILDARSGTDAPTTWRK 784
>At3g55020 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 814
Score = 162 bits (411), Expect = 2e-39
Identities = 106/325 (32%), Positives = 165/325 (50%), Gaps = 43/325 (13%)
Query: 241 LIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLE----------------DHKGENS 284
LIR G+P LRGE+W+ G R KD YQ LL D KG ++
Sbjct: 240 LIRGGVPMALRGELWQAFVGVRKRRC--KDYYQNLLAADGSVNTIEQEDMQHVDDKGSST 297
Query: 285 QAIE-------EIEKDLNRSLPDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVV 337
++I +IEKDL R+ P + A D +G + LR +L AY+ NP VGYCQAMN
Sbjct: 298 ESIAVVEKWKGQIEKDLPRTFPGHPALDD-DGRNALRRLLTAYARHNPSVGYCQAMNFFA 356
Query: 338 AVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKY 397
A+LL+ M EE AFW+L L D Y GYYS+ M + +DQ V E V + P + +H+
Sbjct: 357 ALLLLLMPEENAFWALIGLIDDYFNGYYSEEMIESQVDQLVLEELVRERFPKLVHHLDYL 416
Query: 398 DIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKT-LFQVALAILKVNADDLLEVD 456
+Q++ V+ PWFLS+F +P + R+ D+ G + LF+ ALA++++ L+
Sbjct: 417 GVQVAWVTGPWFLSIFMNMLPWESVLRVWDVLLFEGTRVMLFRTALALMELYGPALVTTK 476
Query: 457 DDGMFIAILKSYFQRLDDSAHPESSDVKYRQITKFQELLVVAFKEFDIITEELVETERNK 516
D G + +L+S DS+ +L++ A + + E ++ R+K
Sbjct: 477 DAGDAVTLLQSLTGSTFDSS----------------QLVLTACMGYQNVHEIRLQELRSK 520
Query: 517 YKKGILHDIESFAKRTQLRNVSKAV 541
++ ++ +E +K Q SK +
Sbjct: 521 HRPAVIAALEERSKGLQAWRDSKGL 545
>Hs11034851 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 777
Score = 162 bits (410), Expect = 2e-39
Identities = 92/315 (29%), Positives = 168/315 (53%), Gaps = 19/315 (6%)
Query: 230 LSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEE 289
+SL R L+ GIP+ +R ++W SG++ ++ ++ Y++++++ + + A ++
Sbjct: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
Query: 290 IEKDLNRSLPDYAAYQDPE--GIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEE 347
IEKDL R++P A + G+ +LR VL A +W P++GYCQ +V A LL+F+ EE
Sbjct: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
Query: 348 QAFWSLCNLC-DLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSL 406
AFW + + DL Y+S T+ G DQRV + +P + + ++DI+LS+++L
Sbjct: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
Query: 407 PWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILK 466
WFL+ F + ++ RI D+FF G + LFQ+ L +L + ++L++ ++ L
Sbjct: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLS 338
Query: 467 SYFQRLDDSAHPESSDVKYRQITKFQELLVVAFKEFDIITEELVETERNKYKKGILHDIE 526
+++D+ + LL VA + +T+ VET+R K+ ++ D
Sbjct: 339 DIPSQMEDA----------------ELLLGVAMRLAGSLTDVAVETQRRKHLAYLIADQG 382
Query: 527 SFAKRTQLRNVSKAV 541
L N+S+ V
Sbjct: 383 QLLGAGTLTNLSQVV 397
>7299972 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 804
Score = 160 bits (405), Expect = 9e-39
Identities = 91/300 (30%), Positives = 157/300 (52%), Gaps = 19/300 (6%)
Query: 228 MNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAI 287
+++ L R ++R GIP+ LR ++W SG++ ++ ++ Y +++ +
Sbjct: 147 VDVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTS 206
Query: 288 EEIEKDLNRSLPDYAAYQDPEG--IDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMS 345
++IEKDL R LP A + +P G I +LR +L +W PD+GYCQ ++VA LL+FM
Sbjct: 207 KQIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFME 266
Query: 346 EEQAFWSLCNLC-DLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVV 404
EE AFW + + DL YYS T+ G DQRV + + + + + + K+DI+LS++
Sbjct: 267 EENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLI 326
Query: 405 SLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAI 464
+L WFL+LF + ++ RI D FF G LFQ+ L +LKV DL +++
Sbjct: 327 TLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENSAQI--- 383
Query: 465 LKSYFQRLDDSAHPESSDVKYRQITKFQELLVVAFKEFDIITEELVETERNKYKKGILHD 524
F L D ++T + L A + +++ +++T R ++ ++ D
Sbjct: 384 ----FNSLSDIP---------GEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMAD 430
>At3g07890 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 389
Score = 153 bits (386), Expect = 1e-36
Identities = 96/295 (32%), Positives = 153/295 (51%), Gaps = 19/295 (6%)
Query: 240 KLIRVGIPNRLRGEIWELCSGSMYERF-MNKDLYQKLLEDHKGENSQAIEEIEKDLNRSL 298
+LIR GIP LR ++W SG+ ++ + + Y L + +G + A +I+ DL R+
Sbjct: 100 RLIRKGIPPVLRPKVWFSLSGAAKKKSTVPESYYSDLTKAVEGMVTPATRQIDHDLPRTF 159
Query: 299 PDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFM-SEEQAFWSLCNLC 357
P + PEG LR VLV YS+++ DVGYCQ +N V A+LL+ M +EE AFW L L
Sbjct: 160 PGHPWLDTPEGHAALRRVLVGYSFRDSDVGYCQGLNYVAALLLLVMKTEEDAFWMLAVLL 219
Query: 358 D-LYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIA 416
+ + V Y+ + G ++QRVF+ + K + H+ +S+V+ WFL LF +
Sbjct: 220 ENVLVRDCYTTNLSGCHVEQRVFKDLLAQKCSRIATHLEDMGFDVSLVATEWFLCLFSKS 279
Query: 417 MPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSA 476
+P + R+ D+ F G K LF ALAI K+ ++LL G I IL+ +L D
Sbjct: 280 LPSETTLRVWDVLFYEGAKVLFHAALAIFKMKENELLMTHQVGDVINILQKTSHQLFDP- 338
Query: 477 HPESSDVKYRQITKFQELLVVAFKEFDIITEELVETERNKYKKGILHDIESFAKR 531
ELL VAF++ +T + +R K + ++ +++ +R
Sbjct: 339 ---------------DELLTVAFEKIGSMTTNTISKQRKKQEPAVMAELDQRLRR 378
>Hs8922167 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 468
Score = 147 bits (370), Expect = 1e-34
Identities = 84/291 (28%), Positives = 147/291 (49%), Gaps = 14/291 (4%)
Query: 240 KLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLP 299
+L+R G+P R +W + YQ+LL + A +IE DLNR+ P
Sbjct: 160 QLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFP 219
Query: 300 DYAAYQDPEGI--DKLRNVLVAYSWKNPDVGYCQAMNIVVAV-LLIFMSEEQAFWSLCNL 356
+ + P DKLR VL+A+SW+NP +GYCQ +N + A+ LL+ EE AFW L +
Sbjct: 220 NNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAI 279
Query: 357 CDLYVPG-YYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFI 415
+ +P YY T+ + +DQRV + + K+P + H+ ++ + LS+V+ WFL +F
Sbjct: 280 VETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFAD 339
Query: 416 AMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDS 475
++ R+ D F G K +F+ ALAI K N ++L + + L+ + + + +S
Sbjct: 340 SLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNS 399
Query: 476 ------AHPESSDVKYRQITKF----QELLVVAFKEFDIITEELVETERNK 516
A + + + +Q+ + +E L +E + + E +E ++
Sbjct: 400 RKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASR 450
>CE29155 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 908
Score = 146 bits (369), Expect = 1e-34
Identities = 91/315 (28%), Positives = 152/315 (47%), Gaps = 29/315 (9%)
Query: 216 LRLWFEYFKSNGMN--LSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMY---ERFMNKD 270
L+ W + +N ++ +++ P LIR G+P RG +W++ + +
Sbjct: 599 LQSWDAFLVNNTVSRQTAIMSSPDLKTLIRTGVPPAYRGRVWKIIVTHWVKDKQAELGNG 658
Query: 271 LYQKLL-----EDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEG--IDKLRNVLVAYSWK 323
YQ +L + G AI++I+ DL R+LP + +P+ I+KLRNVL A+ +
Sbjct: 659 YYQSMLRKAGTKKQDGSYDAAIKQIDLDLARTLPTNKLFDEPDSANIEKLRNVLYAFRYH 718
Query: 324 NPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLYVP-GYYSKTMYGTLLDQRVFESF 382
N VGYCQ +N + A+ L+ + E+ +FW L + P GYY+ ++ G + DQ+V
Sbjct: 719 NSHVGYCQGLNRLAAIALLNLDEQDSFWFLVACVEHLQPEGYYTSSLIGAVADQKVLRDL 778
Query: 383 VESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVAL 442
V K+P + H+ ++ LS+ +L WFL+ F +P I D F G K LF+ AL
Sbjct: 779 VAEKLPKLAAHLRALEVDLSLFALSWFLTCFVDVLPHSIYLTIFDAFLYEGNKVLFRFAL 838
Query: 443 AILKVNADDLLEVDDDGMFIAILKSYFQRLDDSAHPESSDVKYRQITKFQELLVVAFKEF 502
A+ K+ +L+ G L + + D F+ L VAF E
Sbjct: 839 ALFKICEPHVLQCKTIGTVHQCLSKAQEHIID----------------FKSLAQVAFNEL 882
Query: 503 DIITEELVETERNKY 517
+ ++ +ET+R Y
Sbjct: 883 NPFPQKTIETKRQLY 897
>SPAC4G8.04 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 772
Score = 140 bits (354), Expect = 7e-33
Identities = 86/281 (30%), Positives = 149/281 (52%), Gaps = 20/281 (7%)
Query: 238 FYKLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRS 297
F +L++ G+P + ++W CSG+ + + Y++LL S ++ +I+ D+NR+
Sbjct: 497 FRELVKNGVPLCYKAKVWLECSGAY--QLHSPGYYEELLSRTDEVESASVAQIDMDINRT 554
Query: 298 LPDYAAYQDP-EGIDKLRNVLVAYSWKNPDVGYCQAMNIVVA-VLLIFMSEEQAFWSLCN 355
+ + GI KLR +LVAYS NP +GYCQ MN++ A +LL++ SEE AF+ L +
Sbjct: 555 MAKNVFFGGKGPGIPKLRRILVAYSRHNPHIGYCQGMNVIGAFLLLLYASEEDAFYMLMS 614
Query: 356 LCD-LYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFF 414
+ + + P Y++ + + DQ V +SFV+ +P +++H+ + L +S WFLS++
Sbjct: 615 IIENVLPPKYFTPDLMTSRADQLVLKSFVKESLPEIYSHLELLGVDLDAISFHWFLSVYT 674
Query: 415 IAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDD 474
+P +FRI D+ F +G LF+VAL ILK +L + + L Q
Sbjct: 675 DTLPTNISFRIFDMLFCDGYVCLFRVALTILKSLKQQILACNSSSAIYSFLSDLVQY--- 731
Query: 475 SAHPESSDVKYRQITKFQELLVVAFKEFDIITEELVETERN 515
S P+S + A + ++TE+ +E +RN
Sbjct: 732 SFQPDSF------------IKEAADRWSKLVTEKSIERKRN 760
>CE10236 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 808
Score = 133 bits (334), Expect = 1e-30
Identities = 79/296 (26%), Positives = 155/296 (51%), Gaps = 16/296 (5%)
Query: 233 LRHPAFYKLIRVG-IPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIE 291
L+ F +L++ G IP+ +R +W SG+ ++ K Y+ +L+ + +IE
Sbjct: 137 LKTDRFEELLKEGGIPHSMRPFLWPRLSGATKKQKDAKYTYESVLQQCAQDKPSIGVQIE 196
Query: 292 KDLNRSLPDYAAY--QDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQA 349
+DL R+LP+ + ++ EGI+ LR +L ++ PD+GYCQ M ++VA LL++ SEE
Sbjct: 197 RDLLRTLPNNICFWKKNSEGIEALRRILKCVAFIYPDLGYCQGMGVIVATLLLYCSEETT 256
Query: 350 FWSLCNLC-DLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPW 408
FW + L D+ P +Y++T+ G D+RV ++ +P + + Y++++S++++ W
Sbjct: 257 FWMMTALIEDILPPNFYTQTLLGLQADERVSRHLMKCHVPDLNKALEDYEVEVSLLTVSW 316
Query: 409 FLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSY 468
L+LF + R+ D F +G +F+V ++ILK+ +++E+ + A + +
Sbjct: 317 LLTLFGSVFRTRVMLRVWDFIFYSGGVNIFRVIISILKMKEQEIVEIAETTQSSADIFTA 376
Query: 469 FQRLDDSAHPESSDVKYRQITKFQELLVVAFKEFDIITEELVETERNKYKKGILHD 524
+L S ++Y +F IT+ L+ R K++ ++ D
Sbjct: 377 LSQLPASVTEVEKVIEYMGSFEF------------TITDHLIAELRKKHQAVLMAD 420
>YOL112w [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 492
Score = 130 bits (328), Expect = 7e-30
Identities = 81/254 (31%), Positives = 125/254 (48%), Gaps = 32/254 (12%)
Query: 240 KLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHK--GENSQAIEEIEKDLNRS 297
K +R GIP RG W +G + N +Y +L D + + + +E IE+DL R+
Sbjct: 142 KFVRKGIPAEWRGNAWWYFAGGQRQLDANVGVYDRLKSDCREGAVSGKDMEAIERDLYRT 201
Query: 298 LPDYAAYQ-------DPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAF 350
PD + +P I LR VL+A+S + +GYCQ+MN +V +LL+FM EE+AF
Sbjct: 202 FPDNIHFHKESFQNGEPAIIRSLRRVLMAFSVYDKTIGYCQSMNFLVGLLLLFMEEEKAF 261
Query: 351 WSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHI---------------- 394
W L + Y+PG Y + G +DQ V ++ +P +W+HI
Sbjct: 262 WMLVIITGKYLPGVYESDLEGANVDQGVLVLCIKEYLPEIWSHIESSYMNGNGSTDQISG 321
Query: 395 ----AKYDIQLSVVSL---PWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKV 447
+Y +L ++L WF+S F +P++ RI D F LF+VAL ILK+
Sbjct: 322 PASGEEYLCRLPTLTLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFLFKVALGILKL 381
Query: 448 NADDLLEVDDDGMF 461
+ + LE +F
Sbjct: 382 SESEFLESKSQKLF 395
>CE08508 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 1244
Score = 129 bits (324), Expect = 2e-29
Identities = 80/298 (26%), Positives = 145/298 (47%), Gaps = 13/298 (4%)
Query: 241 LIRVGIPNRLRGEIWELCSGSMYERFMN---KDLYQKLLEDHKGENSQAIEEIEK----- 292
+ R GIPN LR +W++ E N K Y+ L GE+ + ++ +
Sbjct: 371 MCRKGIPNSLRATVWKILINQQVEDLKNVYGKYYYRNLCNIQGGEDEKTYSDVHQKQINL 430
Query: 293 DLNRSLPDYAAYQ--DPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAF 350
DL R++P+ + + +G+ +L VL A+ N +GYCQ MN + A L+F+ E AF
Sbjct: 431 DLLRTMPNNVHFMSANSKGVTQLLQVLHAFCLHNSQIGYCQGMNFLAATALLFVGPEDAF 490
Query: 351 WSLCNLCDLYVPG-YYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWF 409
W L + + Y Y+ + G DQ V + +E + P + H+ DI ++ +L WF
Sbjct: 491 WFLIAVTERYFDKTYFDSNLTGAQADQEVLKGLLEVQHPKIMKHLKSLDIDVASFTLNWF 550
Query: 410 LSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYF 469
+SLFF A+P RI D F + GPK LF+ A+ ++ + ++++ D + + K+
Sbjct: 551 ISLFFDAVPFNTLLRIWDCFLLEGPKVLFRFAIVLIGKHEEEIISRGDAIGIMRVSKAAT 610
Query: 470 QRLDDSAHPESSDVKYRQITKFQELLVVAFKEFDIITEELVETER--NKYKKGILHDI 525
+ D + + + EL + + +++ E L + R N++ K I +++
Sbjct: 611 KLAFDEEAIVNMAFRIPNLPTRIELKNMQLQYVNLLAERLEKKMRRANEFVKSIANNL 668
>Hs21361485 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 533
Score = 129 bits (323), Expect = 3e-29
Identities = 82/245 (33%), Positives = 121/245 (48%), Gaps = 9/245 (3%)
Query: 204 PGDPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMY 263
P D A Q+E W + F + LS R R GIP+ LR + W+ S S
Sbjct: 49 PVDVARQRELK----WLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQYLSNSKE 103
Query: 264 ERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLP--DYAAYQDPEGIDKLRNVLVAYS 321
N +++L + + + ++ IEKDL+R P + A + G L +L AY+
Sbjct: 104 LLEQNPGKFEEL--ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYT 161
Query: 322 WKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFES 381
PD GYCQA V AVLL+ M EQAFW L +CD Y+PGYYS + LD +F +
Sbjct: 162 IYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFA 221
Query: 382 FVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVA 441
+ P+ H+ + I + WF+ +F +P R+ D+FF G K +F+VA
Sbjct: 222 LLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVA 281
Query: 442 LAILK 446
L +L+
Sbjct: 282 LVLLR 286
>Hs13994322 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 508
Score = 129 bits (323), Expect = 3e-29
Identities = 81/268 (30%), Positives = 127/268 (47%), Gaps = 9/268 (3%)
Query: 181 EKNIDKNRELQPPSLGLGQIYKYPGDPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYK 240
E+ IDK + G + + P + Q+E W + +N +H
Sbjct: 52 ERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESK----WLDML-NNWDKWMAKKHKKIRL 106
Query: 241 LIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPD 300
+ GIP LRG W+ SG + N + +L D + + ++ IE+DL+R P
Sbjct: 107 RCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDEL--DMSPGDPKWLDVIERDLHRQFPF 164
Query: 301 YAAY--QDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCD 358
+ + + G L VL AY+ P+ GYCQA + AVLL+ M EQAFW L +C+
Sbjct: 165 HEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICE 224
Query: 359 LYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMP 418
Y+PGYYS+ + LD + S ++ PV H+++ I + WF+ F +P
Sbjct: 225 KYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLP 284
Query: 419 LQFAFRIMDIFFVNGPKTLFQVALAILK 446
R+ D+FF G K +F+V L +LK
Sbjct: 285 WSSVLRVWDMFFCEGVKIIFRVGLVLLK 312
>At5g15930 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 356
Score = 127 bits (319), Expect = 8e-29
Identities = 90/266 (33%), Positives = 140/266 (51%), Gaps = 16/266 (6%)
Query: 210 QKEKAKLRLWFEYFKSNGMNLS--LLRHPAFYKL-IRVGIPNRLRGEIWELCSGSMYERF 266
+KE+ ++ W + + G + + R P K IR GIP+ LRG +W+L SGS
Sbjct: 47 EKEEKRVTKWRKMIGTGGSDWKHYVRRKPHVVKRRIRKGIPDCLRGLVWQLISGSRDLLL 106
Query: 267 MNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDK--LRNVLVAYSWKN 324
MN +Y +L+ E S + +I +D++R+ P + +Q G + L NVL AYS +
Sbjct: 107 MNPGVYVQLVIY---ETSASELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYD 163
Query: 325 PDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLYV----PGYYSKTMYGTLLDQRV-- 378
DVGY Q M + +LL++MSEE AFW L L V G Y + L+ Q +
Sbjct: 164 RDVGYVQGMGFIAGLLLLYMSEEDAFWLLVALLKGAVHSPIEGLYQAGL--PLVQQYLLQ 221
Query: 379 FESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLF 438
F+ V MP + H + I S+ + WF+++F ++P A RI D+F G K +F
Sbjct: 222 FDQLVRELMPKLGEHFTQEMINPSMYASQWFITVFSYSLPFHSALRIWDVFLAEGVKIVF 281
Query: 439 QVALAILKVNADDLLEVDDDGMFIAI 464
+V LA+LK DDLL++ + + A+
Sbjct: 282 KVGLALLKHCHDDLLKLPFEELMHAL 307
>At3g02460 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 304
Score = 126 bits (317), Expect = 1e-28
Identities = 88/254 (34%), Positives = 137/254 (53%), Gaps = 16/254 (6%)
Query: 211 KEKAKLRLWFEYFKSNGMNLS--LLRHP-AFYKLIRVGIPNRLRGEIWELCSGSMYERFM 267
+E+ K+R W + G + + R P + IR GIP+ LRG +W+L SGS M
Sbjct: 51 REERKVRKWRKMIGVGGSDWKHYVRRKPNVVRRRIRKGIPDCLRGLVWQLISGSRDLLLM 110
Query: 268 NKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDK--LRNVLVAYSWKNP 325
N +Y++L+ E S + +I +D++R+ P + +Q G + L NVL AYS +
Sbjct: 111 NPGVYEQLVIY---ETSASELDIIRDISRTFPSHVFFQKRHGPGQRSLYNVLKAYSVYDR 167
Query: 326 DVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCD--LYVP--GYYSKTMYGTLLDQRVF-- 379
DVGY Q M + +LL++MSEE AFW L L ++ P G Y + L+ Q +F
Sbjct: 168 DVGYVQGMGFIAGLLLLYMSEEDAFWLLVALLKGAVHAPMEGLYHAGL--PLVQQYLFQL 225
Query: 380 ESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQ 439
ES V+ +P + H + I S+ + WF+++F + P A RI D+F G K +F+
Sbjct: 226 ESLVKELIPKLGEHFTQEMINPSMYASQWFITVFSYSFPFPLALRIWDVFLSEGVKIVFK 285
Query: 440 VALAILKVNADDLL 453
V LA+LK D+L+
Sbjct: 286 VGLALLKYCQDELV 299
>YNL293w [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 633
Score = 125 bits (315), Expect = 2e-28
Identities = 79/261 (30%), Positives = 128/261 (48%), Gaps = 45/261 (17%)
Query: 240 KLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKG--------ENSQAIEEIE 291
+ +R GIP RG W + + NK +Y +LL K + Q ++ IE
Sbjct: 218 RYVRKGIPAEWRGNAWWHFARGQEKLNKNKGVYSQLLRKMKQIKKQNPNEKQVQDLDIIE 277
Query: 292 KDLNRSLPDYAAYQD-------PEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFM 344
+DLNR+ PD +Q P I LR VLVA+S NP +GYCQ+MN + +LL+F+
Sbjct: 278 RDLNRTFPDNIHFQSSLHNKEGPPIIKSLRRVLVAFSLYNPKIGYCQSMNFLAGLLLLFL 337
Query: 345 SEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHI---------- 394
EE+AFW L + Y+PG ++ + G +DQ V V+ +P +W++I
Sbjct: 338 DEERAFWMLVIITSRYLPGVHNINLEGVNIDQGVLMLCVKEYIPEVWSYIKPSIDHHQKN 397
Query: 395 ----------AKYDIQ----------LSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGP 434
+++Q +++ + WF+S F +P++ RI D F
Sbjct: 398 NKTFSPSNKKVLFNMQKNEFLYRLPPITLCTASWFMSCFVGVVPIETTLRIWDCLFYEES 457
Query: 435 KTLFQVALAILKVNADDLLEV 455
LF+V+LA+LK++ DL ++
Sbjct: 458 HFLFKVSLAVLKLSEHDLSKI 478
>SPCC4G3.09c [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 635
Score = 125 bits (314), Expect = 3e-28
Identities = 81/274 (29%), Positives = 127/274 (45%), Gaps = 41/274 (14%)
Query: 219 WFEYFKSNGMNLSLLRHPAFY--------KLIRVGIPNRLRGEIWELCSGSMYERFMNKD 270
W + + NG++ + + P+ + + IR GIP RG W SG N
Sbjct: 267 WKLFLQENGIDY-IHQSPSIFPSRSAKTQRFIRKGIPPEYRGNAWFYYSGGYELLQRNPK 325
Query: 271 LYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQ--------------------DPEGI 310
LY+ L + + IE+DL R+ PD ++ D I
Sbjct: 326 LYETLWRCACIKKPSDSDLIERDLYRTFPDNVHFRHKSKHSRNSSDASEHSSEEPDVPMI 385
Query: 311 DKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMY 370
KLR VL+ ++ P+ GYCQ++N + L+FMSEE+AFW L C Y+P + +
Sbjct: 386 SKLRRVLMTFATYLPENGYCQSLNFLAGFFLLFMSEEKAFWMLVITCRKYLPKMHDANLE 445
Query: 371 GTLLDQRVFESFVESKMPVMWNHIA-KYD-----------IQLSVVSLPWFLSLFFIAMP 418
G +DQ V + V +P +W+ I+ +D +++V+ WF+S F +P
Sbjct: 446 GANIDQSVLMASVRESLPAVWSRISLNFDGIPVNDIVAKLPPITLVTAAWFMSAFVGILP 505
Query: 419 LQFAFRIMDIFFVNGPKTLFQVALAILKVNADDL 452
+ A R+ D FF G K LF AL IL++ DD+
Sbjct: 506 TETALRVWDCFFYEGSKVLFMTALCILRLGEDDI 539
>7300111 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 299
Score = 123 bits (308), Expect = 2e-27
Identities = 73/232 (31%), Positives = 120/232 (51%), Gaps = 8/232 (3%)
Query: 240 KLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLP 299
+ IR GIP R ++W SG+ + + DL++ LL + + + I DL R+ P
Sbjct: 34 RYIRKGIPGPYRPDVWMKISGAAAAQRRSPDLFRNLLRTEPFDK-EISDSISIDLPRTFP 92
Query: 300 DYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMS-EEQAFWSLCNLCD 358
D + + +L N+L+AY+ N DVGYCQ +N + +LLI EE++FW L ++ +
Sbjct: 93 DNIHFDMKK--QRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHIVE 150
Query: 359 LYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMP 418
VP Y+S M L D VF V ++P + H+ + V++ WF+ +F +P
Sbjct: 151 NIVPQYHSHNMANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVLP 210
Query: 419 LQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQ 470
++ RI D F G K +F+ AL + + + +L DD IA L + F+
Sbjct: 211 VETVLRIWDCVFAEGYKIVFRAALTMFVTHKNAILGCDD----IAALANLFR 258
>7299471 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 363
Score = 122 bits (307), Expect = 2e-27
Identities = 66/205 (32%), Positives = 108/205 (52%), Gaps = 4/205 (1%)
Query: 243 RVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYA 302
R GIP +R + W SG+ + N ++Y +LLE K N IEEI+KD +R P +
Sbjct: 75 RKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLE--KPGNPTTIEEIKKDKHRQFPFHE 132
Query: 303 AYQDPEGIDKLR--NVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLY 360
+ D + + ++ NVL AYS NP VG+CQA + A LL+ + E AFW ++CD+Y
Sbjct: 133 MFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVY 192
Query: 361 VPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQ 420
+ Y+ + D + E ++ P ++ H+ K+ ++ + WFL +P +
Sbjct: 193 LQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWE 252
Query: 421 FAFRIMDIFFVNGPKTLFQVALAIL 445
R+ D F G + +F+VAL I+
Sbjct: 253 TLLRVWDCFLAEGIRVIFKVALVII 277
>Hs12232373 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 997
Score = 122 bits (305), Expect = 3e-27
Identities = 77/258 (29%), Positives = 128/258 (48%), Gaps = 9/258 (3%)
Query: 205 GDPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYE 264
GD + + + L W E +NL++ R L+R G+P LRGE+W+L +G
Sbjct: 455 GDVSKECAEKILETWGELLSKWHLNLNV-RPKQLSSLVRNGVPEALRGEVWQLLAGCHNN 513
Query: 265 RFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDP--EGIDKLRNVLVAYSW 322
+ + Y+ L+ ++S I +D+NR+ P + ++D +G D L + AYS
Sbjct: 514 DHL-VEKYRILITKESPQDSA----ITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSV 568
Query: 323 KNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLC-DLYVPGYYSKTMYGTLLDQRVFES 381
+ ++GYCQ + + AVLL+ M EEQAF L + D + + + E
Sbjct: 569 YDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLER 628
Query: 382 FVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVA 441
++ +P ++NH ++ + + WFL+LF PL F I+D+ G +F VA
Sbjct: 629 LMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVA 688
Query: 442 LAILKVNADDLLEVDDDG 459
L +LK + DDLL D +G
Sbjct: 689 LGLLKTSKDDLLLTDFEG 706
>CE07531 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 480
Score = 119 bits (298), Expect = 2e-26
Identities = 90/299 (30%), Positives = 148/299 (49%), Gaps = 17/299 (5%)
Query: 177 EYIIEKNIDKNRELQPPSLGLGQIYKYPGDPALQKEKAKL-RLWFEYFKSNGMNLSLLRH 235
E + + N + +R + G + K + + ++++ L +W E + + + +
Sbjct: 87 EQLNKSNEEDSRSVASKKTGSSESRKGAREHSPEEDEEDLWSVWGELILN--WEIEVKKR 144
Query: 236 PAFYK-LIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDL 294
P + K L++ GIP R W+ S + DLY D+ ++S + I++D+
Sbjct: 145 PNYIKDLVKRGIPQHFRMIAWQNLSNASVSSV--HDLYS----DYMRQSSVYEKVIQRDI 198
Query: 295 NRSLPDYAAYQDPE-GIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSL 353
R+ P+ ++D E G L NV+ AYS + +VGYCQ +V +LL+ M EE+AF L
Sbjct: 199 PRTYPELDFFKDGERGQSLLFNVIKAYSVHDKEVGYCQGSAFIVGLLLLQMPEEEAFAVL 258
Query: 354 CNLCDLY-VPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSL 412
+L + Y + Y TM L E V+ +MP ++ H S+ + WFL+L
Sbjct: 259 VSLMENYRLRELYKPTMTDLGLCMFQLECLVQDQMPDLYTHFNNMGFDTSMYASSWFLTL 318
Query: 413 FFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQR 471
F MPL A RIMD F V G +F +++AIL+ +LL +D +GM YFQR
Sbjct: 319 FTTTMPLDIANRIMDCFLVEGMDFIFCISIAILQQARIELLRLDMEGML-----KYFQR 372
>Hs18590199 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 794
Score = 119 bits (297), Expect = 3e-26
Identities = 97/318 (30%), Positives = 159/318 (49%), Gaps = 22/318 (6%)
Query: 240 KLIRVGIPNRLRGEIWEL-CSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSL 298
+LIR GIP+ R +W+L CS + K+ Y +LL+ +S + I +D+ R+
Sbjct: 110 ELIRKGIPHHFRAIVWQLLCSAT---DMPVKNQYSELLK----MSSPCEKLIRRDIARTY 162
Query: 299 PDYAAY--QDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNL 356
P++ + QD G + L NV+ AYS + +VGYCQ +V +LL+ M EE+AF L
Sbjct: 163 PEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRL 222
Query: 357 CDLY-VPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFI 415
Y + + +M L FE ++ ++P + H S+ + WFL+LF
Sbjct: 223 MQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLT 282
Query: 416 AMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGM---FIAILKSYFQRL 472
PL A R+ DIF G + +F+V LA+L+VN +L+++D +GM F ++ F
Sbjct: 283 TFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSC 342
Query: 473 DDSAHPESSDVKYR-QITKFQELLVVAFKEFDIITEELVETERNKYKKGILHD-IESFAK 530
D ++ VKY + K E A K ++ EE +E +R + + +L IE+ K
Sbjct: 343 PDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEM--EEQIEIKRLRTENRLLKQRIETLEK 400
Query: 531 RTQLRNVSKAVHLSQNEV 548
V++A +N V
Sbjct: 401 ----GQVTRAQEAEENYV 414
>Hs19923325_1 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 707
Score = 117 bits (294), Expect = 6e-26
Identities = 89/302 (29%), Positives = 153/302 (50%), Gaps = 22/302 (7%)
Query: 240 KLIRVGIPNRLRGEIWEL-CSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSL 298
+L+ GIP+ R +W+L CS + KD Y +LL+ S + I +D+ R+
Sbjct: 158 ELVHKGIPHHFRAIVWQLLCSA---QSMPIKDQYSELLK----MTSPCEKLIRRDIARTY 210
Query: 299 PDYAAYQDPE--GIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNL 356
P++ +++ + G + L NV+ AYS + +VGYCQ +V +LL+ M EE+AF L
Sbjct: 211 PEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKL 270
Query: 357 CDLY-VPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFI 415
Y + + +M L FE ++ +P ++ H S+ + WFL++F
Sbjct: 271 MQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLT 330
Query: 416 AMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGM---FIAILKSYFQRL 472
PL A RI DIF G + +F+V LA+L++N +L+++D +GM F ++ F +
Sbjct: 331 TFPLPVATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGV 390
Query: 473 DDSAHPESSDVKY--RQITKFQ-ELLVVAFKEFDIITEELVETERNKYKKGILHD-IESF 528
D + V+Y +++ K + E + KE EE VE +R + + +L IE+
Sbjct: 391 PDKLIQAAYQVQYNSKKMKKLEKEYTTIKTKEM----EEQVEIKRLRTENRLLKQRIETL 446
Query: 529 AK 530
K
Sbjct: 447 EK 448
>Hs7661864 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 828
Score = 115 bits (288), Expect = 3e-25
Identities = 71/223 (31%), Positives = 116/223 (51%), Gaps = 6/223 (2%)
Query: 238 FYKLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRS 297
F++ I GIP +LRGE+W L + +DLY KL +G S I +I+ D+NR+
Sbjct: 93 FHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARG-CSPDIRQIDLDVNRT 151
Query: 298 LPDYAAYQDPEGIDK--LRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCN 355
D+ ++D G+ + L +VL AYS N +VGYCQ M+ + A+LL++M+EE AFW+L
Sbjct: 152 FRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVK 211
Query: 356 LCD---LYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSL 412
L + G++ + L Q E + + + H+ +I S ++ WF
Sbjct: 212 LFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQC 271
Query: 413 FFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEV 455
F P RI DI+ G + L ++ ILK++ L+++
Sbjct: 272 FLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKL 314
>Hs13376023 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 257
Score = 112 bits (281), Expect = 2e-24
Identities = 69/192 (35%), Positives = 103/192 (52%), Gaps = 8/192 (4%)
Query: 268 NKDLYQKLLEDHKGENSQAIEE-IEKDLNRSLPDYAAYQ---DPEGIDKLRNVLVAYSWK 323
N Y +LL+ GE + +E+ I DLNR+ PD ++ DP L NVL+AY
Sbjct: 4 NPGYYHQLLQ---GERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHH 60
Query: 324 NPDVGYCQAMNIVVAVL-LIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESF 382
N VGYCQ MN + L LI +EE++FW L L +P YYS M G DQ V
Sbjct: 61 NQGVGYCQGMNFIAGYLVLITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGEL 120
Query: 383 VESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVAL 442
V +K+P + + + + +++ WF+ LF +P++ RI D F G K +F+VAL
Sbjct: 121 VRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVAL 180
Query: 443 AILKVNADDLLE 454
++K + + +LE
Sbjct: 181 TLIKQHQELILE 192
>At2g37290 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 544
Score = 112 bits (280), Expect = 3e-24
Identities = 88/322 (27%), Positives = 141/322 (43%), Gaps = 73/322 (22%)
Query: 241 LIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLED--HKGENSQAIE-----EIEKD 293
L+R+G+P LRGE+W+ G R + YQ LL + ENS ++ +IEKD
Sbjct: 183 LVRLGVPKDLRGEVWQAFVGVKARRV--ERYYQDLLAQITNSDENSSDVQRKWKKQIEKD 240
Query: 294 LNRSLPDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQ-----------------AMNIV 336
+ R+ P + A + G D LR +L+AY+ NP VGYCQ AMN
Sbjct: 241 IPRTFPGHPALNE-NGRDSLRRILLAYACHNPSVGYCQVTWARKSIFEYPIALIVAMNFF 299
Query: 337 VAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAK 396
+LL+ M EE AFW+L + D Y GYY++ M + +DQ VFE + + P
Sbjct: 300 AGLLLLLMPEENAFWTLVGIIDDYFDGYYTEEMIESQVDQLVFEELMRERFP-------- 351
Query: 397 YDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPK-TLFQVALAILKVNADDLLEV 455
+ R+ D+ G + LF+ A AI+++ ++
Sbjct: 352 -----------------------KLVLRMWDVLLFEGNRVVLFRTAFAIMELYGPAIVAT 388
Query: 456 DDDGMFIAILKSYFQRLDDSA---------HPESSDVKYRQITKFQELLVVAFKEFDIIT 506
D G I L+S DS+ + +++ + ++ K V+ +I+
Sbjct: 389 KDAGDAITSLQSLASSTFDSSQLVLTACMGYISTNEARLEELRKIHRPAVL-----EIVE 443
Query: 507 EELVETERNKYKKGILHDIESF 528
E + + K KKG+ + SF
Sbjct: 444 ERIQKGRVWKDKKGLASKLYSF 465
>7295111 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1194
Score = 111 bits (277), Expect = 6e-24
Identities = 79/278 (28%), Positives = 137/278 (48%), Gaps = 28/278 (10%)
Query: 191 QPPSLGLGQIYKYPGDPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRL 250
+P G G++ K L + LR W + NL+ L+R+G+P L
Sbjct: 609 EPLLSGTGEVSKDCSQDTLDEWDPILREWDS--EKRPKNLA--------PLVRLGVPEAL 658
Query: 251 RGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQD--PE 308
R +IW+ + MN D Y+ L+ + ++ I++D++R+ P + +++
Sbjct: 659 REKIWQKLANVEGRMEMN-DKYKILIT----KETKCETVIQRDIHRTFPAHKCFKEIGGS 713
Query: 309 GIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLC------DLYVP 362
G D L V AY+ + +VGYCQ ++ + A LL+ M EE AF L L DLY
Sbjct: 714 GQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKA 773
Query: 363 GYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFA 422
G+ + +Y L E ++ ++P + H I+ + + WFL+L+ PL F
Sbjct: 774 GF--EVLYLRLYQ---LERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFV 828
Query: 423 FRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGM 460
F ++D+F ++G LFQVA+ +L + DL ++D +G+
Sbjct: 829 FHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGI 866
>CE17203 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 458
Score = 108 bits (269), Expect = 5e-23
Identities = 58/209 (27%), Positives = 104/209 (49%), Gaps = 5/209 (2%)
Query: 243 RVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYA 302
R GIP LRG W+ SG+ Y+ ++ + + + + + ++I+KDL+R P++
Sbjct: 185 RKGIPPSLRGRAWKYLSGATYQMEVSSNRFVFDYCVKQAGDPKWNDDIQKDLSRQFPEHE 244
Query: 303 AYQ-----DPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLC 357
+ G + L ++L A++ +P+ GYCQ + AVLL+ M AF+ +C
Sbjct: 245 MFARVGKYGNNGKNDLFDLLKAWTILHPEEGYCQGQAPIAAVLLMHMPVRDAFYCFVQIC 304
Query: 358 DLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAM 417
Y+PGYYS + D + ++ + + + H + ++ + WF+ F +
Sbjct: 305 HKYLPGYYSSGLEAVQTDGDILTKLIKDRSKLTYRHFKANGVDPALYMIEWFMCCFCRTL 364
Query: 418 PLQFAFRIMDIFFVNGPKTLFQVALAILK 446
P R+ D+F G K LF+VAL +LK
Sbjct: 365 PWPTVLRVWDMFLCEGVKILFKVALVLLK 393
>CE28759 [TR] KOG2223 Uncharacterized conserved protein contains TBC domain
Length = 614
Score = 107 bits (267), Expect = 9e-23
Identities = 77/278 (27%), Positives = 133/278 (47%), Gaps = 30/278 (10%)
Query: 245 GIPNRLRGEIWELCSGSMYERFMNKDLYQKLLED----------HKGENSQ-----AIEE 289
G+P ++RGE+W L G+ E + K+LY L++ + +NS ++ +
Sbjct: 298 GVPAKVRGELWFLTIGNQIE--ITKELYDGLMDQAEEKIAKQLAEQNKNSAERKETSVTQ 355
Query: 290 IEKDLNRSLPDYAAYQ-DPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQ 348
I D R+ +Q D D L +L AY+ PD+GY Q+M + AVLLI M
Sbjct: 356 IHLDATRTFTSLGMFQKDGPYYDHLLKLLSAYAILRPDIGYVQSMTFIAAVLLIQMDPYP 415
Query: 349 AFWSLCNLCDLYVPGYYSKTMYGTLLDQRV-FESFVESKMPVMWNHIAKYDIQLSVVSLP 407
AF S NL D + + + + + ++ ++E ++P + H+ K D++ + +
Sbjct: 416 AFISFANLLDRSLQSAFFGLKQPQMTEYFIAYDRYLEQELPALHQHLDKLDVRPDLYLIE 475
Query: 408 WFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILK- 466
W +++ ++PL RI D++F +G + LF+ AL IL++ LL +D D + K
Sbjct: 476 WTFAMYAKSLPLDVTCRIWDVYFRDGEEFLFKAALGILRMYEPKLLTMDFDDCVEFLTKL 535
Query: 467 -------SYFQRLDDSAHP---ESSDVKYRQITKFQEL 494
F+ ++ P ESS K R FQE+
Sbjct: 536 PNTLTGAELFRNIEPFMRPYNGESSRSKKRFSQIFQEI 573
>7292646 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 803
Score = 107 bits (267), Expect = 9e-23
Identities = 68/230 (29%), Positives = 119/230 (51%), Gaps = 10/230 (4%)
Query: 234 RHPAFYKLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKD 293
++P +L+R GIP+ R +W+ SG+ D +K ++ S + I +D
Sbjct: 105 KNPCVSELVRRGIPHHFRAIVWQQLSGA-------SDGDKKQYAEYIKATSACEKVIRRD 157
Query: 294 LNRSLPDYAAYQDPEGI--DKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFW 351
+ R+ P+ +++ +G + L NV+ AYS + +VGYCQ +V +LL+ M EE+AF
Sbjct: 158 IARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFA 217
Query: 352 SLCNLCDLYVPGYYSKTMYGTL-LDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFL 410
L + + + K L L E+ V+ ++P M H + Q ++ + WFL
Sbjct: 218 VLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFL 277
Query: 411 SLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGM 460
+L+ + + + RIMD+F G + +F+VALA+L D LL +D + M
Sbjct: 278 TLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAM 327
>CE28983 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1005
Score = 105 bits (263), Expect = 3e-22
Identities = 76/250 (30%), Positives = 125/250 (49%), Gaps = 24/250 (9%)
Query: 209 LQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYERFMN 268
L +EK L++ E +KS G + + I GIP +LR IW G+ +
Sbjct: 483 LSREKKWLKM-IEVWKSGGPSKKMEDR------IWKGIPEKLRIVIWPRLLGAERLKHER 535
Query: 269 KDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDK--LRNVLVAYSWKNPD 326
+D+Y +LL + S+ I++I+ D+NR+ D+ A++ + + L NVL AYS N +
Sbjct: 536 RDVYAELLLRARLV-SKDIKQIDLDINRTYRDHLAFRKRYDVKQKSLLNVLAAYSMFNTE 594
Query: 327 VGYCQAMNIVVAVLLIFMSEEQAFWSLCNLC--------DLYVPGYYSKTMYGTLLDQRV 378
VGYCQ M+ + A+ L+++ EE AFWSL L +VPG+ Y +
Sbjct: 595 VGYCQGMSQIAALFLMYLDEEDAFWSLHQLMVSPKHTMHGFFVPGFPKLQRY-----EEH 649
Query: 379 FESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLF 438
F+ ++ P ++ H+ K DI + W+ F +P A R+ D+F V G L
Sbjct: 650 FKRVLKKYKPRVYKHLEKQDIPY-IYLTKWWFGCFLDRVPFSLALRLWDVFLVEGDCILI 708
Query: 439 QVALAILKVN 448
+A I+K++
Sbjct: 709 AMAYNIMKMH 718
>7303241 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 457
Score = 105 bits (263), Expect = 3e-22
Identities = 65/238 (27%), Positives = 121/238 (50%), Gaps = 16/238 (6%)
Query: 239 YKLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSL 298
+K + GIP+R+R W N +Y ++L+ + +++ +I+ D+NR
Sbjct: 97 HKRVYKGIPDRVRMVAWNKLLDIQQSINNNAGVYLRMLQLARKYSTET-RQIDADVNRQF 155
Query: 299 PDYAAYQDPEGIDK--LRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNL 356
D A+++ + + L NVL AYS N ++GYCQ M V VLL+++ EE+AFW+L L
Sbjct: 156 RDNLAFRERYSVKQCSLFNVLNAYSIYNSELGYCQGMACVAGVLLLYLHEEEAFWALNTL 215
Query: 357 C--------DLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPW 408
L++ G+ T + +D + + M + H K+++ + ++ W
Sbjct: 216 ITDQKYGMHGLFIEGFPKLTRF---IDHH--DRIMSKIMRKLHKHFTKHNVDALLYAIKW 270
Query: 409 FLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILK 466
F +F +P + R+ DIF ++G + + +A+ IL ++ D+LL + D I L+
Sbjct: 271 FFVVFVERVPFSLSLRVWDIFMLDGDRVILSMAITILYLHKDELLRLKDMDAIIEYLQ 328
>Hs7662198 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 1299
Score = 105 bits (261), Expect = 4e-22
Identities = 87/310 (28%), Positives = 144/310 (46%), Gaps = 18/310 (5%)
Query: 239 YKLIRVGIPNRLRGEIWELCSGS--MYERFMNKDL-----YQKLLEDHKGENSQAIEEIE 291
+ L++ G+P RGEIW+ + + R NK Y++LL+ + I
Sbjct: 913 HTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQ----HAIL 968
Query: 292 KDLNRSLPD--YAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQA 349
DL R+ P Y + Q G L N+L AYS + +VGYCQ ++ V VLL+ MSEEQA
Sbjct: 969 VDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQA 1028
Query: 350 FWSLCNLC-DLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPW 408
F L L DL Y M + + ++NH+ + +I S+ + PW
Sbjct: 1029 FEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPW 1088
Query: 409 FLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSY 468
FL+LF L F R+ DI F+ G + +F+VAL++L ++E + + LK+
Sbjct: 1089 FLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNT 1148
Query: 469 FQRLDDSAHPE-SSDVKYRQITKFQELLVVAFKEFDIITEELVETERNKYKKGILHDIES 527
++ S + + V I+K V E+ ++ +EL E+ + L +E
Sbjct: 1149 LPDMNTSEMEKIITQVFEMDISKQLHAYEV---EYHVLQDELQESSYSCEDSETLEKLER 1205
Query: 528 FAKRTQLRNV 537
+ + +N+
Sbjct: 1206 ANSQLKRQNM 1215
>CE27154 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1140
Score = 105 bits (261), Expect = 4e-22
Identities = 69/230 (30%), Positives = 117/230 (50%), Gaps = 18/230 (7%)
Query: 240 KLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLP 299
+L+ GIP++LRG +W+L S DL +K + + + I +D++R+ P
Sbjct: 455 ELVLDGIPDKLRGRVWQLLSNVRILAIDQPDLVEKY-HIFLSQPCPSEQVIMRDIHRTFP 513
Query: 300 --DYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLC 357
DY +G L + YS + +V YCQ ++ + A LL+ M EEQAF +L +
Sbjct: 514 AHDYFKESQGKGQQSLYKISKVYSLYDEEVSYCQGLSFLAASLLLHMPEEQAFCTLVKIM 573
Query: 358 ------DLYVPGYYSKTMYGTLLDQRVFE--SFVESKMPVMWNHIAKYDIQLSVVSLPWF 409
DL+ G+ + L R F+ + ++ +P + +H+ I+ + + WF
Sbjct: 574 FNYGLRDLFKLGFDN-------LHLRFFQLTALLKDYIPDLSHHLEHIGIETHMYASQWF 626
Query: 410 LSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDG 459
L+LF PLQ F I+D+F G T+F ++LA+L DLL++D +G
Sbjct: 627 LTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLDDAKTDLLQLDFEG 676
>7296688 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 1379
Score = 105 bits (261), Expect = 4e-22
Identities = 81/355 (22%), Positives = 162/355 (44%), Gaps = 37/355 (10%)
Query: 212 EKAKLRLWFEYFKSNGMNLSLLRHPAFY-KLIRVGIPNRLRGEIWELCSGSMY------- 263
+K + W + + N + + P IR G+P RG++W +
Sbjct: 709 DKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVD 768
Query: 264 -ERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDKLR--NVLVAY 320
+RF N + +L H E+ AI DL R+ P++ Y+DP G+ +L N+L AY
Sbjct: 769 TKRFPNFNTPYHMLLKHLTEHQHAIFI---DLGRTFPNHQFYKDPLGLGQLSLFNLLKAY 825
Query: 321 SWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLC-DLYVPGYYSKTMYGTLLDQRVF 379
S +P++GYCQ + + VLL+ E +F L +L + Y M L
Sbjct: 826 SILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQL 885
Query: 380 ESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQ 439
V+ +P ++ + + D+ ++ + PW L++F PL F R+ D+ F+ +F+
Sbjct: 886 SRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFK 945
Query: 440 VALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSAHPESSDVKY-----RQITKFQEL 494
A+A+L V+ LL D+ + LK+ +++ + + + + +Q+ +++
Sbjct: 946 FAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYK-- 1003
Query: 495 LVVAFKEFDIITEELVETERNKYKKGILHDIESF-AKRTQLRNVSKAVHLSQNEV 548
E++++ EE+ T H +E ++TQ +++ + + +Q+ +
Sbjct: 1004 -----VEYNVLQEEITTTN---------HHLEMLNREKTQNQHLEQQLQFAQSSI 1044
>CE27153 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1136
Score = 103 bits (258), Expect = 1e-21
Identities = 68/230 (29%), Positives = 120/230 (51%), Gaps = 22/230 (9%)
Query: 240 KLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLP 299
+L+ GIP++LRG +W+L S ++ + + + + L + E + I +D++R+ P
Sbjct: 455 ELVLDGIPDKLRGRVWQLLSNAIDQPDLVEKYHIFLSQPCPSE-----QVIMRDIHRTFP 509
Query: 300 --DYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLC 357
DY +G L + YS + +V YCQ ++ + A LL+ M EEQAF +L +
Sbjct: 510 AHDYFKESQGKGQQSLYKISKVYSLYDEEVSYCQGLSFLAASLLLHMPEEQAFCTLVKIM 569
Query: 358 ------DLYVPGYYSKTMYGTLLDQRVFE--SFVESKMPVMWNHIAKYDIQLSVVSLPWF 409
DL+ G+ + L R F+ + ++ +P + +H+ I+ + + WF
Sbjct: 570 FNYGLRDLFKLGFDN-------LHLRFFQLTALLKDYIPDLSHHLEHIGIETHMYASQWF 622
Query: 410 LSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDG 459
L+LF PLQ F I+D+F G T+F ++LA+L DLL++D +G
Sbjct: 623 LTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLDDAKTDLLQLDFEG 672
>At2g39280 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 579
Score = 103 bits (256), Expect = 2e-21
Identities = 94/383 (24%), Positives = 150/383 (38%), Gaps = 97/383 (25%)
Query: 241 LIRVGIPNRLRGEIWELCSGSMYERFMN------------KDLYQKLLE--DHKGENSQA 286
LI G P LRGE+W+ +G R N D+ Q+L++ D KG ++
Sbjct: 207 LIHGGAPMALRGELWQAFAGVKKRRVKNYYQNLLAADSLGNDIEQELMQHTDEKGSSTDP 266
Query: 287 IE-------EIEKDLNRSLPDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQ-------- 331
+ +IEKDL R+ P + A D + + LR +L AY+ NP VGYCQ
Sbjct: 267 LSVVEKWKGQIEKDLPRTFPGHPALDD-DFRNALRRLLTAYARHNPSVGYCQYGYMLTKM 325
Query: 332 ---------------AMNIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQ 376
AMN A+LL+ M EE AFWSL + D Y YYS+ M + +DQ
Sbjct: 326 NISVICYLVSINHVQAMNFFAALLLLLMPEENAFWSLTGIIDDYFHDYYSEEMLESQVDQ 385
Query: 377 RVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKT 436
RV E + + P + R+ D+ G +
Sbjct: 386 RVLEELLRERFP-------------------------------KLVLRVWDVLLFEGNRV 414
Query: 437 -LFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSAHPESSDVKYRQITKFQELL 495
LF+ ALA+++ L+ D G + +L+S DS+ +L+
Sbjct: 415 MLFRTALALMEFYGPALVTTKDIGDAVTLLQSMTGSTFDSS----------------QLV 458
Query: 496 VVAFKEFDIITEELVETERNKYKKGILHDIESFAKRTQL----RNVSKAVHLSQNEVXXX 551
A + + E ++ R+K++ ++ E K Q ++ + +H S+ +
Sbjct: 459 FTACMGYQNVHESKLQELRSKHRPAVIAAFEERLKGLQAWRDSKDTATKLHNSKQDPNSV 518
Query: 552 XXXXXXXXXXXXXXMGTGSSKMD 574
+GSS D
Sbjct: 519 LASKASLSNGSLSRSESGSSYAD 541
>Hs20532509 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 937
Score = 102 bits (253), Expect = 4e-21
Identities = 78/306 (25%), Positives = 143/306 (46%), Gaps = 18/306 (5%)
Query: 218 LWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMY------ERFMNKDL 271
+W + + G + + + G+P RGEIW+ + + + KD+
Sbjct: 542 VWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDV 601
Query: 272 -YQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDKLR--NVLVAYSWKNPDVG 328
Y++LL+ + I DL R+ P + + G +L N+L AYS + +VG
Sbjct: 602 PYKELLKQLTSQQ----HAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVG 657
Query: 329 YCQAMNIVVAVLLIFMSEEQAFWSLCNLC-DLYVPGYYSKTMYGTLLDQRVFESFVESKM 387
YCQ ++ V +LL+ MSEE+AF L L D+ + Y M + +
Sbjct: 658 YCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYH 717
Query: 388 PVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKV 447
++NH+ +++I S+ + PWFL++F PL F R+ D+ F+ G + +F+VAL++L
Sbjct: 718 RDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGS 777
Query: 448 NADDLLEVDDDGMFIAILKSYFQRLD-DSAHPESSDVKYRQITKFQELLVVAFKEFDIIT 506
+ +L+ ++ + +KS L + V I K + V E+ ++
Sbjct: 778 HKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEV---EYHVLQ 834
Query: 507 EELVET 512
EEL+++
Sbjct: 835 EELIDS 840
>Hs14745035 [TR] KOG2223 Uncharacterized conserved protein contains TBC domain
Length = 775
Score = 100 bits (249), Expect = 1e-20
Identities = 65/232 (28%), Positives = 118/232 (50%), Gaps = 20/232 (8%)
Query: 245 GIPNRLRGEIWELCSGS-------MYERFMN--KDLYQKLLE-----DHKG----ENSQA 286
G+P +RG++W L G+ +YE F++ K+ ++ E D +G + +
Sbjct: 484 GLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREAS 543
Query: 287 IEEIEKDLNRSLPDYAAYQDPEGI-DKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMS 345
+E I+ D++R+ P +Q D L ++L AY+ PDVGY Q M+ + AVL++ +
Sbjct: 544 LELIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLE 603
Query: 346 EEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQ-RVFESFVESKMPVMWNHIAKYDIQLSVV 404
E AF + NL + + + + +L FE F E + ++ H Y + +
Sbjct: 604 EADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIY 663
Query: 405 SLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVD 456
+ W +L+ ++PL A R+ D+F +G + LF+ L IL++ D LL++D
Sbjct: 664 LIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMD 715
>Hs14733591 [TR] KOG2223 Uncharacterized conserved protein contains TBC domain
Length = 693
Score = 99.4 bits (246), Expect = 2e-20
Identities = 69/236 (29%), Positives = 115/236 (48%), Gaps = 26/236 (11%)
Query: 245 GIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKG------------ENSQA------ 286
GIP +RG++W L G+ E + +L+ L K EN A
Sbjct: 401 GIPPSVRGKVWSLAIGN--ELNITHELFDICLARAKERWRSLSTGGSEVENEDAGFSAAD 458
Query: 287 ----IEEIEKDLNRSLPDYAAYQDPEGI-DKLRNVLVAYSWKNPDVGYCQAMNIVVAVLL 341
+E I+ D++R+ P+ +Q D L ++L AY+ PDVGY Q M+ + AVL+
Sbjct: 459 REASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 518
Query: 342 IFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQ-RVFESFVESKMPVMWNHIAKYDIQ 400
+ + AF + NL + + + +G +L FE F E +P ++ H K ++
Sbjct: 519 LNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLT 578
Query: 401 LSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVD 456
+ + W +L+ ++PL A RI D+F +G + LF+ AL ILK+ D L ++D
Sbjct: 579 PDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMD 634
>YPL249c [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 894
Score = 95.5 bits (236), Expect = 3e-19
Identities = 66/223 (29%), Positives = 111/223 (49%), Gaps = 27/223 (12%)
Query: 245 GIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEE--IEKDLNRSLPDYA 302
GIP ++RG IW+L + S +D+Y+ LL+ ++ + E I +DL R+
Sbjct: 451 GIPPQIRGIIWQLMANSKSREM--EDIYETLLD------TECLHEATIRRDLRRT----- 497
Query: 303 AYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLC-------N 355
+ + ++ L V+ YS +PDVGY Q M + A LLI E + L
Sbjct: 498 KFVAEDKMESLYKVIKVYSVYDPDVGYTQGMGFIAAPLLINCENEAESFGLLVGLMKNYG 557
Query: 356 LCDLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFI 415
L +L++PG M G +L F+ +E P ++N + + I ++ + WFL+ F
Sbjct: 558 LRELFLPG-----MPGLMLMLYQFDRLLEEHSPSLYNRLIREGISSTMYATQWFLTFFAY 612
Query: 416 AMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDD 458
PL+F RI DI FV G + L + A+ ++ N + L+++ D
Sbjct: 613 KFPLEFVLRIFDIVFVEGIEVLLKFAVNLMLKNEETLVKLRFD 655
>Hs4758564_1 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 498
Score = 90.9 bits (224), Expect = 8e-18
Identities = 66/233 (28%), Positives = 111/233 (47%), Gaps = 12/233 (5%)
Query: 245 GIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAY 304
GIP +RG +W + + N YQ + E K +S+ I I+ D+ +L ++ +
Sbjct: 100 GIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGK-RSSEHIHHIDLDVRTTLRNHVFF 158
Query: 305 QDPEGIDK--LRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDL--- 359
+D G + L +L+AYS NP+VGYC+ ++ + A+ L+++ EE AFW+L L
Sbjct: 159 RDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERH 218
Query: 360 YVPGYYSK---TMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIA 416
+PG++S T+ G L DQ+ E V P H K + SL L
Sbjct: 219 SLPGFHSPNGGTVQG-LQDQQ--EHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDG 275
Query: 417 MPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYF 469
+ L R+ D++ V G + L + LKV L++ G++ + +F
Sbjct: 276 ISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFF 328
>Hs22062568 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 219
Score = 90.5 bits (223), Expect = 1e-17
Identities = 57/168 (33%), Positives = 83/168 (48%), Gaps = 5/168 (2%)
Query: 204 PGDPALQKEKAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSMY 263
PG P + + W E S+ R+ R GIP+ LR W L G+
Sbjct: 52 PGHPPADLIRQREMKWVE-MTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHV 110
Query: 264 ERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDK--LRNVLVAYS 321
+ + YQ+L E + Q +E I +DL+R P + + P+G + L VL AY+
Sbjct: 111 CQKNSPGTYQELAE--APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYT 168
Query: 322 WKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTM 369
P+ GYCQA V AVLL+ + E+AFW L +C++Y+PGYY M
Sbjct: 169 LYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHM 216
>Hs14149985 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 549
Score = 85.5 bits (210), Expect = 4e-16
Identities = 64/249 (25%), Positives = 119/249 (47%), Gaps = 15/249 (6%)
Query: 245 GIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAY 304
G+P +RG +W + + + N YQ + E K ++S+ I+ I++D++ +L + +
Sbjct: 101 GMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGK-KSSEHIQRIDRDVSGTLRKHIFF 159
Query: 305 QDPEGIDK--LRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDL--- 359
+D G + L ++L+AY NP+VGYC+ ++ + A+ L+++ EE AFW+L L
Sbjct: 160 RDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERH 219
Query: 360 YVPGYYSK---TMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIA 416
+ G++S T+ G L DQ+ E V + P H K D+ L + +
Sbjct: 220 SLQGFHSPNGGTVQG-LQDQQ--EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDG 276
Query: 417 MPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSA 476
+ L R+ D++ V G + L + KV L + G + + +D A
Sbjct: 277 ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRF---VDTWA 333
Query: 477 HPESSDVKY 485
E + +K+
Sbjct: 334 RDEDTVLKH 342
>Hs22066444 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 422
Score = 84.3 bits (207), Expect = 8e-16
Identities = 64/249 (25%), Positives = 117/249 (46%), Gaps = 15/249 (6%)
Query: 245 GIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAY 304
G+P +RG +W + + N YQ + E K +S+ I+ I++D++ +L + +
Sbjct: 21 GMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGK-RSSEHIQRIDRDISGTLRKHMFF 79
Query: 305 QDPEGIDK--LRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDL--- 359
+D G + L ++L+AY NP+VGYC+ ++ + A+ L+++ EE AFW+L L
Sbjct: 80 RDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERH 139
Query: 360 YVPGYYSK---TMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIA 416
+ G++S T+ G L DQ+ E V + P H K D+ L + +
Sbjct: 140 SLQGFHSPNGGTVQG-LQDQQ--EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDG 196
Query: 417 MPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSA 476
+ L R+ D++ V G + L + KV L + G + + +D A
Sbjct: 197 ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRF---VDTWA 253
Query: 477 HPESSDVKY 485
E + +K+
Sbjct: 254 RDEDTVLKH 262
>ECU11g1700 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 320
Score = 83.6 bits (205), Expect = 1e-15
Identities = 65/239 (27%), Positives = 114/239 (47%), Gaps = 11/239 (4%)
Query: 232 LLRHPAFYKLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIE 291
L R + +LI GIP L+ +W G +R + D Y L+ G Q +++
Sbjct: 62 LRRSESARRLIYQGIPLSLKYRLW----GLFTQRTSDFD-YSALISRKSGYEHQIHVDVQ 116
Query: 292 KDLNRSLPDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFW 351
+ R Y G +L N+L AYS NP+VGYCQ M+ A+LL++ EE+AF
Sbjct: 117 RTFRRHFLFSREYG--RGQCELFNILTAYSNYNPEVGYCQGMSSAAALLLMYFPEEEAFE 174
Query: 352 SLCNLC-DLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFL 410
L ++ + ++ + K + Q++ + ++ +P +++H+ +I + V ++ W+L
Sbjct: 175 MLVSIIRNNHLEALFDKKLSKVPRVQKIQDEIFKALIPEVYSHLLHQNIDIGVYAVGWYL 234
Query: 411 SLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGM--FIAILKS 467
+L F ++ R+ D F A ILK A +LE+ + + FI L S
Sbjct: 235 TL-FTRFDIKLVLRMWDFFLFFDFSIFMFFAAGILKFFAMGILELQGEQLIEFIGTLDS 292
>Hs20560763 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 469
Score = 80.5 bits (197), Expect = 1e-14
Identities = 63/249 (25%), Positives = 115/249 (45%), Gaps = 15/249 (6%)
Query: 245 GIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAY 304
G+P +RG +W + + N YQ + E K +S+ I+ I++D++ +L + +
Sbjct: 21 GMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKGK-RSSEHIQRIDRDISGTLRKHMFF 79
Query: 305 QDPEGIDK--LRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDL--- 359
+D G + L ++L+AY NP+VGYC+ ++ + A+ L++ EE AFW+L L
Sbjct: 80 RDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYFPEEDAFWALVQLLASERH 139
Query: 360 YVPGYYSK---TMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIA 416
+ G++S T+ G L DQ+ E V + H K D+ L + +
Sbjct: 140 SLQGFHSPNGGTVQG-LQDQQ--EHVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDG 196
Query: 417 MPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSA 476
+ L R+ D++ V G + L + KV L + G + + +D A
Sbjct: 197 ISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRF---VDTWA 253
Query: 477 HPESSDVKY 485
E + +K+
Sbjct: 254 RDEDTVLKH 262
>SPAC26F1.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1031
Score = 79.7 bits (195), Expect = 2e-14
Identities = 71/262 (27%), Positives = 115/262 (43%), Gaps = 25/262 (9%)
Query: 282 ENSQAIEEIEKDLNRSL-PDYAAY-----QDPEGIDK-------LRNVLVAYSWKNPDVG 328
+N + + I KDL+R+ P+ ++ Q E D L VL + + P VG
Sbjct: 641 KNCDSDKAIRKDLDRTFAPEILSHFFSNRQQLEPTDNIAESTANLHRVLRSLAIVLPQVG 700
Query: 329 YCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLY-VPGYYSKTMYGTLLDQRVFESFVESKM 387
Y Q M+ + LL+ + QAF L L Y + +S M G F VE M
Sbjct: 701 YTQGMSWIAGALLMHLPAPQAFALLVFLFKNYHLQNIFSSEMRGLSRVLHQFTRLVEDYM 760
Query: 388 PVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILKV 447
P + H + DI+ + WFL+LF PL+ + DI F+ GP LF LA+L
Sbjct: 761 PSLAIHFKRQDIKTCSYASEWFLTLFAYKFPLEVVAHLYDILFLYGPGILFNFGLALLSH 820
Query: 448 NADDLLEVDDDGMFIAILKSYFQRLDDSAHPESSDVKYRQITKFQ-----ELLVVAFKEF 502
+ + LL+++ D + + + F ++ E+ D T F ++L E+
Sbjct: 821 SQESLLKLNMDRLISYLKEDIFLAFKETQEGENYDTSLFVKTAFSFEIQPDVLDRYGNEY 880
Query: 503 DII------TEELVETERNKYK 518
DI+ + +E RN++K
Sbjct: 881 DILLKSEHELDSSLEEMRNRHK 902
>Hs18580214 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 761
Score = 75.1 bits (183), Expect = 5e-13
Identities = 61/224 (27%), Positives = 105/224 (46%), Gaps = 22/224 (9%)
Query: 242 IRVGIPNRLRGEIW-ELCSGSMYERFMNKDLYQKLLEDHKG---ENSQAIEEIEKDLNRS 297
+ GIP R ++W L ++ ++ D + + + ++S I+ I KDL+R+
Sbjct: 83 LSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQ-IVKDLHRT 141
Query: 298 -LPDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFM--SEEQAFWSLC 354
Y + + L+ VL+AY+ N VGYCQ NI+ A++L M +E A +
Sbjct: 142 GCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMI 201
Query: 355 NLCDLYVP-GYYSKTMYGTLLDQRVFESFVESKMPVMWNHI------------AKYDIQL 401
L D +P Y+ + +D VF + K+P + H+ Y+ L
Sbjct: 202 YLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPL 261
Query: 402 S-VVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAI 444
+ V ++ WFL+LF +P Q +I D F G + + +V+LAI
Sbjct: 262 TNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAI 305
>7299317 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 3052
Score = 73.2 bits (178), Expect = 2e-12
Identities = 62/266 (23%), Positives = 117/266 (43%), Gaps = 41/266 (15%)
Query: 245 GIPNRLRGEIWELCSGSMYERFMNKDLYQK----LLEDHKGENSQAIEEIEKDLNRSLPD 300
G P R ++W L Y + N D Q+ E+ + ++ + +I KDL+R+ +
Sbjct: 100 GTPPEFRRKLW-LSLADKYLKSKNVDWAQQREKCFCEEWREDDEELGIQIVKDLHRTGSN 158
Query: 301 YAAYQDPEGI---DKLRNVLVAYSWKNPDVGYCQA-------------------MNIVVA 338
P G KL+ +L+ Y+ NP+VGYCQ N++ A
Sbjct: 159 LCT--GPAGSINQAKLKRILLGYARYNPEVGYCQVSAPSRIFVCCVHFTHIIQGFNMLGA 216
Query: 339 VLLIFMS--EEQAFWSLCNLCDLYVP-GYYSKTMYGTLLDQRVFESFVESKMPVMWNHIA 395
++L M EE++ + L + +P GY+ +M G D VF +++++P + H+
Sbjct: 217 LILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQ 276
Query: 396 KYDIQL---------SVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAILK 446
+ + +V ++ WFL++F +P+ R+ D+ + G L + AL +
Sbjct: 277 RLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWS 336
Query: 447 VNADDLLEVDDDGMFIAILKSYFQRL 472
+ + ++ V F + SY L
Sbjct: 337 LLEERVISVRSADEFYGKMGSYSSEL 362
>Hs22058425 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 641
Score = 70.9 bits (172), Expect = 9e-12
Identities = 51/170 (30%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 292 KDLNRS-LPDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFM--SEEQ 348
KDL+R+ Y + + L+ VL+AY+ N VGYCQ NI+ A++L M +E
Sbjct: 341 KDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGD 400
Query: 349 AFWSLCNLCDLYVP-GYYSKTMYGTLLDQRVFESFVESKMPVMWNHI------------A 395
A + L D +P Y+ + +D VF + K+P + H+
Sbjct: 401 ALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGG 460
Query: 396 KYDIQLS-VVSLPWFLSLFFIAMPLQFAFRIMDIFFVNGPKTLFQVALAI 444
Y+ L+ V ++ WFL+LF +P Q +I D F G + + +V+LAI
Sbjct: 461 GYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAI 510
>SPAC23D3.03c [TR] KOG2223 Uncharacterized conserved protein contains TBC domain
Length = 472
Score = 65.9 bits (159), Expect = 3e-10
Identities = 72/275 (26%), Positives = 119/275 (43%), Gaps = 38/275 (13%)
Query: 212 EKAKLRLWFEYFKSNGMNLSLLRHPAFYKLIRVGIPNRLRGEIWELCSGSM----YERFM 267
E+ LR W + KS+ + + R GIP+R+RG +WE G+ Y+ F
Sbjct: 192 EREILRNWPDALKSS----------RYAGIWRQGIPSRVRGRVWEKAIGNNLKLDYQSFF 241
Query: 268 N-KDLYQKLLEDHKGE---NSQAIEE----IEKDLNRSLPDYAAYQDPEGIDK-LRNVLV 318
N + QK K E N+ E +E DL ++P Y+ + + + L +L
Sbjct: 242 NARANAQKREAAEKAEQMNNANQFREDVCALELDLQSTMPHYSLFHTEGPLRRDLIGLLR 301
Query: 319 AYSWKNPDVGYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDL-YVPGYYS------KTMYG 371
AYS+ D Y + + A+LL+ M+ AF L NL D ++ Y+ K+ Y
Sbjct: 302 AYSYYRFDTSYIPGTSFIGALLLLNMNLTSAFNCLANLLDKPFLQAVYTQDTSSLKSFYQ 361
Query: 372 TLLDQRVFESFVESKMPVMWNH-IAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFF 430
T LD ++ P + H + K ++ P LF + + A RI+D +
Sbjct: 362 TFLDT------LKKNEPELATHLLIKLELVPDDFVYPLLRKLFIPMVSPEIASRILDCYV 415
Query: 431 VNGPKTLFQVALAILKVNADDLLEVDDDGMFIAIL 465
Q+ +A+ K+ LL VDD + ++ L
Sbjct: 416 FEEDSFFIQLLMAVFKLLKPKLL-VDDSRLVLSAL 449
>Hs14916463 [R] KOG1093 Predicted protein kinase (contains TBC and RHOD
domains)
Length = 822
Score = 64.3 bits (155), Expect = 8e-10
Identities = 55/218 (25%), Positives = 90/218 (41%), Gaps = 9/218 (4%)
Query: 239 YKLIRVGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSL 298
+K RV IP +RG W G + ++ K K +IE D+ R
Sbjct: 389 WKEARVDIPPLMRGLTWAALLG------VEGAIHAKYDAIDKDTPIPTDRQIEVDIPRCH 442
Query: 299 PDYAAYQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLI--FMSEEQAFWSLCNL 356
PEG K R VL A+ +PD+ Y Q ++ + A L F +E A+ +
Sbjct: 443 QYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCAPFLYLNFNNEALAYACMSAF 502
Query: 357 CDLYVPGYYSKTMYGTLLDQ-RVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFI 415
Y+ ++ K + + VF + P + NH+ + + ++PWFL++F
Sbjct: 503 IPKYLYNFFLKDNSHVIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTH 562
Query: 416 AMPLQFAFRIMDIFFVNGPKTLFQVALAILKVNADDLL 453
PL F + D + F + +AIL+ D LL
Sbjct: 563 VFPLHKIFHLWDTLLLGNSSFPFCIGVAILQQLRDRLL 600
>7290543 [R] KOG1093 Predicted protein kinase (contains TBC and RHOD
domains)
Length = 840
Score = 60.5 bits (145), Expect = 1e-08
Identities = 54/213 (25%), Positives = 88/213 (40%), Gaps = 11/213 (5%)
Query: 244 VGIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAA 303
V +P LRG IW ++ E N Y K+ K ++ +IE D+ R
Sbjct: 430 VDVPPLLRGPIW----AALLEVVPNGS-YAKI---DKFTSTSTDRQIEVDIPRCHQYDEL 481
Query: 304 YQDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLI--FMSEEQAFWSLCNLCDLYV 361
P+G KLR +L A+ +P Y Q ++ + A L F +EE AF SL Y+
Sbjct: 482 LSSPDGHRKLRRLLKAWVTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFIPKYL 541
Query: 362 PGYYSKTMYGTLLDQ-RVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQ 420
++ K + + F P++ H+A + ++PWFL++F PL
Sbjct: 542 QWFFLKDNSAVIKEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLH 601
Query: 421 FAFRIMDIFFVNGPKTLFQVALAILKVNADDLL 453
+ D + + +AIL+ LL
Sbjct: 602 KILHLWDKLMLGDSSYPLFIGIAILRQLRSTLL 634
>SPBC1778.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 414
Score = 58.9 bits (141), Expect = 4e-08
Identities = 53/196 (27%), Positives = 91/196 (46%), Gaps = 14/196 (7%)
Query: 273 QKLLEDHKGENSQAIE---EIEKDLNRSLPDYAAYQDPE--GIDKLRNVLVAYSWKNPDV 327
+KL++ + N Q + +I+ D+ R+ + ++ G L VL A + P V
Sbjct: 179 KKLIDKYYQLNEQICDYDVQIDLDVPRTAATHFLFRKRYIGGQRLLFRVLHAVALYIPRV 238
Query: 328 GYCQAMNIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFV-ESK 386
GY Q M + A LLI+ EEQAF + NL + G + + TLL + F+ E
Sbjct: 239 GYVQGMASIAATLLIYYPEEQAFIMMVNLLENRGMGDLFSSGFDTLL--KAFDMLKHELS 296
Query: 387 MPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFFVNG------PKTLFQV 440
H+A+ + S + W+L++F +P RI D+ F+ G + L
Sbjct: 297 FTQSGRHLAEIGAEPSAFATRWYLTVFHQCVPFHTQLRIWDLLFLLGGSKGQTVRLLQAT 356
Query: 441 ALAILKVNADDLLEVD 456
+LA+++ D L++ D
Sbjct: 357 SLAVIQGMWDTLIDAD 372
>Hs20562247 [U] KOG2801 Probable Rab-GAPs
Length = 559
Score = 56.6 bits (135), Expect = 2e-07
Identities = 62/224 (27%), Positives = 104/224 (45%), Gaps = 27/224 (12%)
Query: 250 LRGEIWELCSGSMYERFMNKD--LYQKLLEDHKGENSQAIEEIEKDL-NRSLPDYAAYQD 306
LRG++++ + R + D +Y ++ G++S + + + + N +P Y
Sbjct: 50 LRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSCLPLPEFVDNTQVPSYCLNAR 109
Query: 307 PEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIF-MSEEQAFWSLCNLCDLYVPGYY 365
EG +R +L+ + + PD+ +C A+ VVA+LL + + E + F C + PG
Sbjct: 110 GEGA--VRKILLCLANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILACNDPGR- 166
Query: 366 SKTMYGTLLDQRVFESFVESKMPV--MWNHIAKYDIQLSVVSLPWFLSLF-------FIA 416
L+DQ F +F S M + N + +L V L ++ F
Sbjct: 167 ------RLIDQS-FLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYADWQRWLFGE 219
Query: 417 MPLQFAFRIMDIFFVNGPKTLFQVALAIL----KVNADDLLEVD 456
+PL + R+ D+F V G K L++VALAIL KV A LE D
Sbjct: 220 LPLCYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESD 263
>7295589_1 [R] KOG1648 Uncharacterized conserved protein contains RUN BRK and
TBC domains
Length = 1300
Score = 54.7 bits (130), Expect = 7e-07
Identities = 58/220 (26%), Positives = 101/220 (45%), Gaps = 17/220 (7%)
Query: 268 NKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAYQDPEGIDKLRNVLVAYSWKNPDV 327
N +Y L + G N + IEKD+ R +Y + + E +DKLRNV+ Y W++ DV
Sbjct: 1012 NGGVYSSELLEQFGLN---LHRIEKDVQRCDRNYWYFAN-ENLDKLRNVISTYVWEHLDV 1067
Query: 328 GYCQAM-NIVVAVLLIFMSEEQAFWSLCNLCDLYVPGYYS-KTMYGTLLDQRVFESFVES 385
GY Q M ++V +L+IF E ++ C L + + + S M + R ++S
Sbjct: 1068 GYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDS 1127
Query: 386 KMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQFAFRIMDIFF-----VNGPKTLFQV 440
+M + + + D WFL F + F ++ + +G LF +
Sbjct: 1128 EMYDLMD--SNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-L 1184
Query: 441 ALAILKVNADDLLEVDDDGMFIAILKSYFQRLDDSAHPES 480
ALA+L+ D +L D F ++K +F + + + +S
Sbjct: 1185 ALALLETYRDIILSNSMD--FTDVIK-FFNEMAERHNAQS 1221
>YMR192w [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 720
Score = 53.5 bits (127), Expect = 1e-06
Identities = 54/226 (23%), Positives = 103/226 (44%), Gaps = 15/226 (6%)
Query: 245 GIPNRLRGEIWELCSGSMYERFMNKDLYQKLLEDHKGENSQAIEEIEKDLNRSLPDYAAY 304
GIP R +W+L S + + F +Y+ L + + Q E K ++ +Y
Sbjct: 297 GIPAAYRLVVWQLVSYAKSKSF--DPIYETYLTEMAPFDVQEFENQLKMMDEVPSEY--- 351
Query: 305 QDPEGIDKLRNVLVAYSWKNPDVGYCQAMNIVVAVLLIFMSEE-QAFWSLCNLCDLYVPG 363
+ ++ NVL AY +P+ + + ++ ++L EE AF L L +Y
Sbjct: 352 -----VKRISNVLKAYLLFDPECEFSTDIAYIINMILDVCEEEANAFGLLVRLMKVYGLR 406
Query: 364 --YYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSLPWFLSLFFIAMPLQF 421
+ +L + F+ VE P + NH+ + ++ S+ +F +LF +P +
Sbjct: 407 LLFLPSASEIDILCYK-FDRLVEEFYPEIHNHMVEKGVRSSMFLPGFFTTLFQKKLPTEI 465
Query: 422 AFRIMDIFFVNGPKTLFQVALAILKVNADDLLEVDDDGMFIAILKS 467
RI D+ F+ G ++ ++ +L + D LL++ D M + +LKS
Sbjct: 466 QPRIGDMVFLEGIDSIMRILATLLSNSRDHLLKMGFDDM-LELLKS 510
>Hs13375952 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 648
Score = 52.4 bits (124), Expect = 3e-06
Identities = 41/169 (24%), Positives = 73/169 (42%), Gaps = 6/169 (3%)
Query: 290 IEKDLNRSLPDYAAYQDPE--GIDKLRNVLVAYSWKNPDVGYCQAM-NIVVAVLLIFMSE 346
IE+D++R+ Y+ PE G+ L ++L+ Y + D+GY Q M +++ +L + +E
Sbjct: 375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE 434
Query: 347 EQAFWSLCNLCDLYVPGYYSKTMYGTLLDQRVFESFVESKMPVMWNHIAKYDIQLSVVSL 406
AFW C +L V G + ++ + P++ + + D
Sbjct: 435 VDAFWCFCGFMEL-VQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCF 493
Query: 407 PWFLSLFFIAMPLQFAFRIMDIFFVN--GPKTLFQVALAILKVNADDLL 453
W L F P R+ ++ + GP VA AIL + D L+
Sbjct: 494 RWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLM 542
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.136 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,926,954
Number of Sequences: 60738
Number of extensions: 2226738
Number of successful extensions: 6643
Number of sequences better than 1.0e-05: 68
Number of HSP's better than 0.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 6444
Number of HSP's gapped (non-prelim): 86
length of query: 944
length of database: 30,389,216
effective HSP length: 116
effective length of query: 828
effective length of database: 23,343,608
effective search space: 19328507424
effective search space used: 19328507424
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)