ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV3872 check: MH I KOG1200 Lipid transport and metabolism Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV3872 1311601 1312368 256
(256 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 141 1e-33
At5g06060 [R] KOG0725 Reductases with broad range of substrate s... 135 4e-32
At1g52340 [R] KOG0725 Reductases with broad range of substrate s... 130 1e-30
At2g29260 [R] KOG0725 Reductases with broad range of substrate s... 128 7e-30
Hs19923817 [R] KOG0725 Reductases with broad range of substrate ... 125 8e-29
CE04339 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 124 1e-28
7295487 [R] KOG0725 Reductases with broad range of substrate spe... 124 1e-28
At2g29170 [R] KOG0725 Reductases with broad range of substrate s... 124 2e-28
At3g05260 [R] KOG0725 Reductases with broad range of substrate s... 121 1e-27
Hs7705907 [R] KOG0725 Reductases with broad range of substrate s... 120 1e-27
At2g29370 [R] KOG0725 Reductases with broad range of substrate s... 120 2e-27
At2g29360 [R] KOG0725 Reductases with broad range of substrate s... 120 2e-27
At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP... 120 2e-27
Hs10337605 [R] KOG0725 Reductases with broad range of substrate ... 119 4e-27
At2g29150 [R] KOG0725 Reductases with broad range of substrate s... 119 4e-27
At2g29290 [R] KOG0725 Reductases with broad range of substrate s... 119 5e-27
Hs15277342 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 117 2e-26
7296705 [R] KOG0725 Reductases with broad range of substrate spe... 117 2e-26
CE09969 [R] KOG0725 Reductases with broad range of substrate spe... 115 6e-26
SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate ... 114 2e-25
At2g29350 [R] KOG0725 Reductases with broad range of substrate s... 111 9e-25
At1g07440 [R] KOG0725 Reductases with broad range of substrate s... 111 9e-25
At2g30670 [R] KOG0725 Reductases with broad range of substrate s... 110 2e-24
At2g29340 [R] KOG0725 Reductases with broad range of substrate s... 110 2e-24
At2g29310 [R] KOG0725 Reductases with broad range of substrate s... 110 3e-24
At2g29320 [R] KOG0725 Reductases with broad range of substrate s... 109 4e-24
At2g29300 [R] KOG0725 Reductases with broad range of substrate s... 109 4e-24
At1g54870 [R] KOG0725 Reductases with broad range of substrate s... 108 6e-24
Hs14754051 [R] KOG0725 Reductases with broad range of substrate ... 108 7e-24
7290108 [R] KOG0725 Reductases with broad range of substrate spe... 107 2e-23
7296704 [R] KOG0725 Reductases with broad range of substrate spe... 106 3e-23
At3g55310 [R] KOG0725 Reductases with broad range of substrate s... 106 4e-23
SPAC922.06 [R] KOG0725 Reductases with broad range of substrate ... 105 5e-23
Hs5031737 [R] KOG0725 Reductases with broad range of substrate s... 105 6e-23
CE19894 [R] KOG0725 Reductases with broad range of substrate spe... 105 8e-23
At1g63380 [R] KOG0725 Reductases with broad range of substrate s... 105 8e-23
At2g47120 [R] KOG0725 Reductases with broad range of substrate s... 104 1e-22
At3g46170 [R] KOG0725 Reductases with broad range of substrate s... 103 2e-22
7296706_2 [R] KOG0725 Reductases with broad range of substrate s... 103 2e-22
At2g29330 [R] KOG0725 Reductases with broad range of substrate s... 103 3e-22
At1g62610 [R] KOG0725 Reductases with broad range of substrate s... 103 3e-22
7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 103 3e-22
Hs10190704 [R] KOG0725 Reductases with broad range of substrate ... 102 4e-22
Hs10047132 [R] KOG0725 Reductases with broad range of substrate ... 102 5e-22
Hs4503301 [R] KOG0725 Reductases with broad range of substrate s... 102 7e-22
CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 102 7e-22
At3g26770 [R] KOG0725 Reductases with broad range of substrate s... 101 9e-22
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 101 1e-21
At1g07450 [R] KOG0725 Reductases with broad range of substrate s... 100 2e-21
CE21093 [R] KOG0725 Reductases with broad range of substrate spe... 99 6e-21
SPAC8E11.10 [R] KOG0725 Reductases with broad range of substrate... 99 8e-21
At3g29260 [R] KOG0725 Reductases with broad range of substrate s... 98 1e-20
SPCC1739.08c [R] KOG0725 Reductases with broad range of substrat... 97 2e-20
At3g26760 [R] KOG0725 Reductases with broad range of substrate s... 97 2e-20
Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydrox... 97 3e-20
Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and... 96 4e-20
CE02370 [R] KOG0725 Reductases with broad range of substrate spe... 96 4e-20
At3g51680 [R] KOG0725 Reductases with broad range of substrate s... 96 5e-20
At4g03140 [R] KOG0725 Reductases with broad range of substrate s... 95 8e-20
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 95 1e-19
CE27260 [R] KOG0725 Reductases with broad range of substrate spe... 94 2e-19
At2g47130 [R] KOG0725 Reductases with broad range of substrate s... 94 2e-19
CE27259 [R] KOG0725 Reductases with broad range of substrate spe... 93 3e-19
CE06649 [R] KOG0725 Reductases with broad range of substrate spe... 93 4e-19
At5g50700 [Q] KOG1205 Predicted dehydrogenase 92 5e-19
At5g50600 [Q] KOG1205 Predicted dehydrogenase 92 5e-19
CE02315 [R] KOG0725 Reductases with broad range of substrate spe... 92 7e-19
At4g05530 [R] KOG0725 Reductases with broad range of substrate s... 92 7e-19
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 92 9e-19
Hs7705925 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 91 1e-18
At5g18210 [R] KOG0725 Reductases with broad range of substrate s... 91 1e-18
At3g29250 [R] KOG0725 Reductases with broad range of substrate s... 91 2e-18
7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 91 2e-18
CE10908 [R] KOG0725 Reductases with broad range of substrate spe... 91 2e-18
At4g13180 [R] KOG0725 Reductases with broad range of substrate s... 91 2e-18
CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 89 5e-18
CE21095 [R] KOG0725 Reductases with broad range of substrate spe... 89 5e-18
At2g47140 [R] KOG0725 Reductases with broad range of substrate s... 89 8e-18
At3g04000 [R] KOG0725 Reductases with broad range of substrate s... 88 1e-17
7301818 [Q] KOG1205 Predicted dehydrogenase 88 1e-17
SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate ... 87 2e-17
YNL202w [R] KOG0725 Reductases with broad range of substrate spe... 87 2e-17
At3g03980 [R] KOG0725 Reductases with broad range of substrate s... 87 2e-17
CE21092 [R] KOG0725 Reductases with broad range of substrate spe... 86 4e-17
At5g50590 [Q] KOG1205 Predicted dehydrogenase 86 4e-17
At1g10310 [R] KOG0725 Reductases with broad range of substrate s... 86 4e-17
CE03132 [R] KOG0725 Reductases with broad range of substrate spe... 85 9e-17
CE20725 [R] KOG0725 Reductases with broad range of substrate spe... 85 1e-16
CE12990 [R] KOG0725 Reductases with broad range of substrate spe... 85 1e-16
CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 85 1e-16
CE05726 [R] KOG0725 Reductases with broad range of substrate spe... 85 1e-16
At5g50690 [Q] KOG1205 Predicted dehydrogenase 85 1e-16
At3g42960 [R] KOG0725 Reductases with broad range of substrate s... 85 1e-16
YMR226c [Q] KOG1205 Predicted dehydrogenase 84 1e-16
Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 84 2e-16
CE15574 [R] KOG0725 Reductases with broad range of substrate spe... 84 2e-16
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 84 3e-16
CE12594 [R] KOG0725 Reductases with broad range of substrate spe... 83 3e-16
CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 83 3e-16
At3g47350 [Q] KOG1205 Predicted dehydrogenase 83 3e-16
CE03954 [R] KOG0725 Reductases with broad range of substrate spe... 83 4e-16
7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 83 4e-16
CE26808_2 [R] KOG0725 Reductases with broad range of substrate s... 83 4e-16
CE21514 [R] KOG0725 Reductases with broad range of substrate spe... 82 6e-16
CE03951 [R] KOG0725 Reductases with broad range of substrate spe... 82 7e-16
Hs20149619 [Q] KOG1205 Predicted dehydrogenase 82 1e-15
CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 80 4e-15
7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 79 6e-15
7294452 [Q] KOG1205 Predicted dehydrogenase 79 8e-15
At3g47360 [Q] KOG1205 Predicted dehydrogenase 78 1e-14
7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 78 1e-14
7295621 [Q] KOG1205 Predicted dehydrogenase 78 1e-14
7292690 [Q] KOG1205 Predicted dehydrogenase 78 1e-14
SPCC162.03 [Q] KOG1205 Predicted dehydrogenase 78 1e-14
SPAC22A12.17c [R] KOG0725 Reductases with broad range of substra... 78 1e-14
Hs7706318 [Q] KOG1205 Predicted dehydrogenase 77 2e-14
7290386 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 77 2e-14
7300831 [Q] KOG1205 Predicted dehydrogenase 77 3e-14
YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 76 5e-14
At4g09750 [Q] KOG1208 Dehydrogenases with different specificitie... 75 7e-14
7297069 [Q] KOG1205 Predicted dehydrogenase 75 7e-14
7292613 [Q] KOG1205 Predicted dehydrogenase 74 2e-13
At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase a... 74 2e-13
At3g03330 [Q] KOG1205 Predicted dehydrogenase 74 2e-13
7293189 [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 74 2e-13
7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase 74 3e-13
CE07544 [Q] KOG1205 Predicted dehydrogenase 73 3e-13
YIR036c [Q] KOG1204 Predicted dehydrogenase 73 4e-13
SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reduct... 73 4e-13
At5g61830 [Q] KOG1208 Dehydrogenases with different specificitie... 73 4e-13
At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductas... 72 8e-13
7304180 [Q] KOG1208 Dehydrogenases with different specificities ... 72 8e-13
7300731 [Q] KOG1205 Predicted dehydrogenase 71 1e-12
7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 71 2e-12
Hs19923983 [R] KOG0725 Reductases with broad range of substrate ... 70 2e-12
At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 70 2e-12
SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase 70 3e-12
Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 70 3e-12
CE14538 [R] KOG0725 Reductases with broad range of substrate spe... 70 3e-12
At5g50770 [Q] KOG1205 Predicted dehydrogenase 70 3e-12
7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 70 3e-12
7295622 [Q] KOG1205 Predicted dehydrogenase 70 3e-12
CE07539 [Q] KOG1205 Predicted dehydrogenase 70 4e-12
Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 69 5e-12
Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase 69 5e-12
7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 69 5e-12
CE28758 [R] KOG0725 Reductases with broad range of substrate spe... 69 6e-12
7304181 [Q] KOG1208 Dehydrogenases with different specificities ... 69 8e-12
7290988 [Q] KOG1205 Predicted dehydrogenase 69 8e-12
Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 68 1e-11
Hs20373187 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 68 1e-11
CE11498 [R] KOG0725 Reductases with broad range of substrate spe... 68 1e-11
At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase 67 2e-11
7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 67 2e-11
CE02490_1 [R] KOG0725 Reductases with broad range of substrate s... 67 2e-11
Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 67 3e-11
At5g51030 [Q] KOG1208 Dehydrogenases with different specificitie... 67 3e-11
7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 67 3e-11
CE05427 [R] KOG0725 Reductases with broad range of substrate spe... 66 4e-11
At5g04900 [R] KOG0725 Reductases with broad range of substrate s... 66 4e-11
Hs4759084 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 65 9e-11
7304177 [Q] KOG1208 Dehydrogenases with different specificities ... 65 9e-11
CE13054 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 65 1e-10
7302393 [Q] KOG1208 Dehydrogenases with different specificities ... 65 1e-10
7304176 [Q] KOG1208 Dehydrogenases with different specificities ... 64 2e-10
Hs5031765 [Q] KOG1205 Predicted dehydrogenase 64 2e-10
Hs18582884 [Q] KOG1208 Dehydrogenases with different specificiti... 64 2e-10
At1g01800 [Q] KOG1208 Dehydrogenases with different specificitie... 64 2e-10
YIR035c [Q] KOG1204 Predicted dehydrogenase 64 3e-10
Hs7657478 [Q] KOG1205 Predicted dehydrogenase 63 4e-10
CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 63 4e-10
7304178 [Q] KOG1208 Dehydrogenases with different specificities ... 63 4e-10
CE07803 [Q] KOG1208 Dehydrogenases with different specificities ... 63 5e-10
Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 62 6e-10
Hs10190746 [Q] KOG1208 Dehydrogenases with different specificiti... 62 6e-10
Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 62 8e-10
Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 62 8e-10
7301617_1 [R] KOG0725 Reductases with broad range of substrate s... 62 8e-10
SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase 62 1e-09
Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 61 1e-09
CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 61 2e-09
7300387 [Q] KOG1208 Dehydrogenases with different specificities ... 60 3e-09
7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 60 3e-09
Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 60 4e-09
Hs20070272 [Q] KOG1208 Dehydrogenases with different specificiti... 59 5e-09
CE13008 [R] KOG0725 Reductases with broad range of substrate spe... 59 5e-09
7297516 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 59 7e-09
HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 59 9e-09
At3g61220 [Q] KOG1208 Dehydrogenases with different specificitie... 59 9e-09
At2g24190 [Q] KOG1208 Dehydrogenases with different specificitie... 59 9e-09
SPAC977.08 [Q] KOG1205 Predicted dehydrogenase 58 1e-08
SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase 58 1e-08
YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 57 2e-08
YKL055c [R] KOG0725 Reductases with broad range of substrate spe... 57 3e-08
Hs4507185 [Q] KOG1204 Predicted dehydrogenase 57 3e-08
At5g50130 [Q] KOG1208 Dehydrogenases with different specificitie... 57 3e-08
At4g10020 [Q] KOG1205 Predicted dehydrogenase 57 3e-08
7297912 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 57 3e-08
CE09505 [R] KOG1611 Predicted short chain-type dehydrogenase 57 3e-08
7296047 [Q] KOG1205 Predicted dehydrogenase 57 3e-08
CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 56 4e-08
YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 56 6e-08
CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase 56 6e-08
CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 55 7e-08
SPCC1450.15_1 [Q] KOG1210 Predicted 3-ketosphinganine reductase 55 7e-08
Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 55 1e-07
At1g64590 [Q] KOG1208 Dehydrogenases with different specificitie... 55 1e-07
SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase 55 1e-07
Hs4502601 [Q] KOG1208 Dehydrogenases with different specificitie... 55 1e-07
YBR159w [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 54 2e-07
Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 54 2e-07
Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 54 2e-07
CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 54 2e-07
Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase 54 2e-07
CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 54 2e-07
At2g37540 [Q] KOG1208 Dehydrogenases with different specificitie... 54 2e-07
SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 54 3e-07
CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase 54 3e-07
7297326 [Q] KOG1208 Dehydrogenases with different specificities ... 54 3e-07
Hs21553325 [Q] KOG1208 Dehydrogenases with different specificiti... 53 4e-07
CE27908 [Q] KOG1208 Dehydrogenases with different specificities ... 53 4e-07
CE03613 [R] KOG1611 Predicted short chain-type dehydrogenase 53 4e-07
CE05118 [R] KOG0725 Reductases with broad range of substrate spe... 53 5e-07
CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase 52 6e-07
At5g15940 [Q] KOG1208 Dehydrogenases with different specificitie... 52 6e-07
Hs4502599 [Q] KOG1208 Dehydrogenases with different specificitie... 52 8e-07
7290709 [Q] KOG1208 Dehydrogenases with different specificities ... 52 8e-07
At2g05990 [R] KOG0725 Reductases with broad range of substrate s... 51 1e-06
At4g24050 [Q] KOG1208 Dehydrogenases with different specificitie... 51 2e-06
CE06157 [R] KOG1611 Predicted short chain-type dehydrogenase 50 2e-06
7298168 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 50 2e-06
CE28291 [Q] KOG1208 Dehydrogenases with different specificities ... 50 3e-06
At4g13250 [R] KOG0725 Reductases with broad range of substrate s... 50 4e-06
At3g55290 [R] KOG0725 Reductases with broad range of substrate s... 50 4e-06
Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 49 5e-06
CE08181 [Q] KOG1208 Dehydrogenases with different specificities ... 49 5e-06
CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 49 5e-06
Hs13236542 [Q] KOG1205 Predicted dehydrogenase 49 7e-06
CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 49 9e-06
7294121 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 49 9e-06
7290912 [R] KOG1611 Predicted short chain-type dehydrogenase 49 9e-06
>CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 296
Score = 141 bits (355), Expect = 1e-33
Identities = 81/246 (32%), Positives = 133/246 (53%), Gaps = 7/246 (2%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
+ K+A+VTG +G+G+ I + GA +++ S + TAGN+ +G E+DV
Sbjct: 55 SSKLAIVTGGGSGIGQAICKKFAASGARLIVADLKKSAAEATAGNLPGNGHSAF--EIDV 112
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
+ + V L + I+ + LVN AGIT + + W+ V++ N+N F
Sbjct: 113 SDPEHVARLQEFIKSSGESPSVLVNCAGIT--KDATLLKMSQNQWQDVMNVNLNSVFLMS 170
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
+ + S + S ++VN+S++ G +G G + Y ATK VIG T+S A E A +N+
Sbjct: 171 QM---IARESVAAGSPLSIVNVSSIVGKIGNFGQTNYAATKSGVIGFTKSAARELATKNI 227
Query: 187 RVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTGSV 246
RVNAV PG++ TP +A+P + M S P +R+ E++N VLFL S ++ + TG+
Sbjct: 228 RVNAVLPGFIRTPMTEAMPPKVLDAMVSMVPQRRLGETEEIANAVLFLASDMSSYVTGTT 287
Query: 247 YPIDGG 252
+ GG
Sbjct: 288 LEVTGG 293
>At5g06060 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 135 bits (341), Expect = 4e-32
Identities = 89/253 (35%), Positives = 137/253 (53%), Gaps = 9/253 (3%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S AGK ALVTG + G+G + L GA V SR+ E+ + +G V G
Sbjct: 7 WSLAGKTALVTGGTRGIGRAVVEELAKFGAKVHTCSRNQEELNACLNDWKANGLVVSGSV 66
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
D +V E LIQE F G L+ L+NN G T + +E Y + + +++ TN+
Sbjct: 67 CDASVRDQREKLIQEASSAFSGKLNILINNVG-TNVRKPTVE-YSSEEYAKIMSTNLESA 124
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
F+ + A PL+++S ++V +S+V GLV + S Y ATK A+ +T+++A E+A
Sbjct: 125 FHLSQIAHPLLKASGV----GSIVFISSVAGLVHLSSGSIYGATKGALNQLTRNLACEWA 180
Query: 183 ERNVRVNAVAPGYVSTPKIQAL--PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
N+R N VAP Y+ T ++ L KE + + S+ P+ R+ EVS+ V FL P +
Sbjct: 181 SDNIRTNCVAPWYIKTSLVETLLEKKEFVEAVVSRTPLGRVGEPEEVSSLVAFLCLPASS 240
Query: 241 FTTGSVYPIDGGF 253
+ TG V +DGGF
Sbjct: 241 YITGQVISVDGGF 253
>At1g52340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 285
Score = 130 bits (328), Expect = 1e-30
Identities = 87/263 (33%), Positives = 135/263 (51%), Gaps = 25/263 (9%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV--- 64
GK+AL+TG +TG+GE I R GA V I + G + S R KE
Sbjct: 20 GKVALITGGATGIGESIVRLFHKHGAKVCIVDLQ----DDLGGEVCKSLLRGESKETAFF 75
Query: 65 ---DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNING 121
DV V + + + + FG L L+NNAG+ G I +Y + + D N+ G
Sbjct: 76 IHGDVRVEDDISNAVDFAVKNFGTLDILINNAGLCGAPCPDIRNYSLSEFEMTFDVNVKG 135
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY 181
F ++K+A +M P+ + ++V+L +V G+VG G Y +KHAV+G+T+SVA E
Sbjct: 136 AFLSMKHAARVM----IPEKKGSIVSLCSVGGVVGGVGPHSYVGSKHAVLGLTRSVAAEL 191
Query: 182 AERNVRVNAVAPGYVSTPKIQA-LPKET---------QQWMSSQHPMKRM-ATMTEVSNT 230
+ +RVN V+P V+T A LP+E + + ++ +K + T+ +V+N
Sbjct: 192 GQHGIRVNCVSPYAVATKLALAHLPEEERTEDAFVGFRNFAAANANLKGVELTVDDVANA 251
Query: 231 VLFLLSPLTGFTTGSVYPIDGGF 253
VLFL S + + +G IDGGF
Sbjct: 252 VLFLASDDSRYISGDNLMIDGGF 274
>At2g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 322
Score = 128 bits (322), Expect = 7e-30
Identities = 84/252 (33%), Positives = 136/252 (53%), Gaps = 9/252 (3%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S G ALVTG + G+G I L GA V +R+ E++ + + SG RV G
Sbjct: 66 WSLNGMSALVTGGTRGIGRAIVEELAGLGAEVHTCARNEYELENCLSDWNRSGFRVAGSV 125
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
DV+ E L++ + F G LH LVNN G T + +E + + ++ TN
Sbjct: 126 CDVSDRSQREALMETVSSVFEGKLHILVNNVG-TNIRKPMVE-FTAGEFSTLMSTNFESV 183
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
F+ + A PL+ S + +VV +S+V+G V + +S ++TK A+ +T+S+A E+A
Sbjct: 184 FHLCQLAYPLLRESKA----GSVVFISSVSGFVSLKNMSVQSSTKGAINQLTRSLACEWA 239
Query: 183 ERNVRVNAVAPGYVSTPKIQAL--PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
+ N+R+NAVAP Y+ T ++ + KE + + S P+ R+ EVS+ V FL P +
Sbjct: 240 KDNIRINAVAPWYIKTSMVEQVLSNKEYLEEVYSVTPLGRLGEPREVSSAVAFLCLPASS 299
Query: 241 FTTGSVYPIDGG 252
+ TG + +DGG
Sbjct: 300 YITGQILCVDGG 311
>Hs19923817 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 125 bits (313), Expect = 8e-29
Identities = 86/257 (33%), Positives = 131/257 (50%), Gaps = 22/257 (8%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHL----SEVQETAGNIDPS-GSRVIGK 62
G++A+VTG +TG+G+ I + L G+ VVI SR L S E N+ P+ +RVI
Sbjct: 18 GQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPI 77
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
+ ++ + V +L++ + FG +++LVNN G G + E W V++TN+ GT
Sbjct: 78 QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG--GQFLSPAEHISSKGWHAVLETNLTGT 135
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
FY K + SS + ++VN+ V G P A + V +T+S+ALE+A
Sbjct: 136 FYMCK----AVYSSWMKEHGGSIVNI-IVPTKAGFPLAVHSGAARAGVYNLTKSLALEWA 190
Query: 183 ERNVRVNAVAPGYVSTPKIQALPKETQQWMSS-------QHPMKRMATMTEVSNTVLFLL 235
+R+N VAPG + + Q + W S + P KR+ EVS+ V FLL
Sbjct: 191 CSGIRINCVAPGVIYS---QTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLL 247
Query: 236 SPLTGFTTGSVYPIDGG 252
SP F TG +DGG
Sbjct: 248 SPAASFITGQSVDVDGG 264
>CE04339 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 255
Score = 124 bits (312), Expect = 1e-28
Identities = 80/241 (33%), Positives = 130/241 (53%), Gaps = 8/241 (3%)
Query: 14 TGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVAKAVE 73
+G ++G+G+ I++ L GA VV+ TA + S S DV+ A +V+
Sbjct: 20 SGGASGIGKAISQTLAKHGARVVVADLDSGNAAATAKALPASQSHS-SFACDVSNADSVK 78
Query: 74 DLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK-YALPL 132
L + ++ G LVN AGIT + + + W VI N+ G F+ + +
Sbjct: 79 GLSEHVKS-LGTPSILVNCAGIT--KDSTLLKMKQEQWDSVIKVNLTGVFHVSQAFVKAS 135
Query: 133 MESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRVNAVA 192
+++++ P S ++N+S++ G +G G + Y ATK VIG T+S A E A++NVRVNAV
Sbjct: 136 VDNNNHPLS---IINVSSIVGKMGNFGQTNYAATKAGVIGFTKSAAKELAKKNVRVNAVL 192
Query: 193 PGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTGSVYPIDGG 252
PG++ TP +A+P + PM RM E++N+VL+L S L+ + TG+ + GG
Sbjct: 193 PGFIKTPMTEAMPPTVLAEICKGIPMGRMGEAEEIANSVLYLASDLSSYVTGATLEVTGG 252
Query: 253 F 253
F
Sbjct: 253 F 253
>7295487 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 317
Score = 124 bits (312), Expect = 1e-28
Identities = 79/252 (31%), Positives = 131/252 (51%), Gaps = 7/252 (2%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
AGK+A+VT ++ G+G IA+ L GA VVI+SR V + V G + V
Sbjct: 70 AGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHV 129
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
+ + + L +E +FG L+ LV+NA T P G+ + D W ++ D N+ ++
Sbjct: 130 SEPEDRKQLFEETISKFGKLNILVSNAA-TNPAVGGVLECDEKVWDKIFDVNVKSSYLLA 188
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
K ALPL+ + +++V +S++ G + Y+ +K A+IG+T++ A + A +
Sbjct: 189 KEALPLLRQQKN----SSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGI 244
Query: 187 RVNAVAPGYVSTPKIQAL--PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTG 244
RVN +APG + T +AL + + S+ PM R+ T E++ V FL+S G+ TG
Sbjct: 245 RVNCLAPGVIRTKFSKALYENESANEAALSKIPMGRLGTSEEMAGVVSFLVSEDAGYITG 304
Query: 245 SVYPIDGGFLAQ 256
GG A+
Sbjct: 305 ESIVAGGGMTAR 316
>At2g29170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 124 bits (310), Expect = 2e-28
Identities = 84/253 (33%), Positives = 135/253 (53%), Gaps = 12/253 (4%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S G ALVTG S G+GE + L + GA V +R+ +++QE G V
Sbjct: 14 WSLGGMTALVTGGSKGLGEAVVEELAMLGARVHTCARNETQLQECVREWQAKGFEVTTSV 73
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAG--ITGPHQTGIEDYDIDSWRQVIDTNIN 120
DV+ E L++ + F G L+ LVNNAG IT P +Y + ++ TN++
Sbjct: 74 CDVSSRDQREKLMENVASIFQGKLNILVNNAGTGITKP----TTEYTAQDYSFLMATNLD 129
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
F+ + A PL+++S S ++V +S+ G+V I S Y ATK A+ + +++A E
Sbjct: 130 SAFHLSQLAHPLLKASGS----GSIVLMSSTAGVVHINVGSIYGATKGAMNQLAKNLACE 185
Query: 181 YAERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
+A N+RVN+V P +++TP + +E ++ + + PM R+ EVS+ V FL P
Sbjct: 186 WARDNIRVNSVCPWFIATP-LYLNDEELKKEVERKTPMGRVGNANEVSSLVAFLCFPAAS 244
Query: 241 FTTGSVYPIDGGF 253
+ TG +DGGF
Sbjct: 245 YITGQTICVDGGF 257
>At3g05260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 289
Score = 121 bits (303), Expect = 1e-27
Identities = 82/256 (32%), Positives = 131/256 (51%), Gaps = 17/256 (6%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVIT---SRHLSEVQETAGNIDPSGSRVIGKEV 64
GK+ALVTG +G+G+ + + GA+V T R + +ET + +R + +
Sbjct: 39 GKVALVTGGDSGIGKAVCHCYALEGASVAFTYVKGREDKDAEETLRLLHEVKTREAKEPI 98
Query: 65 DVTVAKAVED----LIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNIN 120
+ E+ +++E+ FG + LVN A H+ IED D +V TNI
Sbjct: 99 MIATDLGFEENCKRVVEEVVNSFGRIDVLVNCAA--EQHEVSIEDIDEARLERVFRTNIF 156
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
F+ +KYAL M+ SS ++N ++V G + YTATK A++ T+ +AL+
Sbjct: 157 SQFFLVKYALKHMKEGSS------IINTTSVVAYAGNSSLLEYTATKGAIVSFTRGLALQ 210
Query: 181 YAERNVRVNAVAPGYVSTPKIQA-LPKETQQWMSSQHPMKRMATMTEVSNTVLFL-LSPL 238
A + +RVN VAPG V TP I A +E + S+ PMKR A EV+ + +FL +
Sbjct: 211 LAPKGIRVNGVAPGPVWTPLIPASFSEEAIKQFGSETPMKRAAQPVEVAPSYVFLACNHC 270
Query: 239 TGFTTGSVYPIDGGFL 254
+ + TG + +GG +
Sbjct: 271 SSYYTGQILHPNGGLI 286
>Hs7705907 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 120 bits (302), Expect = 1e-27
Identities = 87/261 (33%), Positives = 128/261 (48%), Gaps = 33/261 (12%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV- 64
+AGK+ +VTG G+G GI RA GA VVI + D SG R + +E+
Sbjct: 7 YAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDK------------DESGGRALEQELP 54
Query: 65 -------DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDT 117
DVT V+ L+ E FG L +VNNAG P Q E+ +RQ+++
Sbjct: 55 GAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRP-EETSAQGFRQLLEL 113
Query: 118 NINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV 177
N+ GT+ K ALP + S + V+N+S++ G +G PY ATK AV +T+++
Sbjct: 114 NLLGTYTLTKLALPYLRKS-----QGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKAL 168
Query: 178 ALEYAERNVRVNAVAPGYVSTPKIQAL------PKETQQWMSSQHPMKRMATMTEVSNTV 231
AL+ + VRVN ++PG + TP + L P+ + + P+ RM EV
Sbjct: 169 ALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRASIREGMLAQPLGRMGQPAEVGAAA 228
Query: 232 LFLLSPLTGFTTGSVYPIDGG 252
+FL S F TG + GG
Sbjct: 229 VFLASE-ANFCTGIELLVTGG 248
>At2g29370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 120 bits (301), Expect = 2e-27
Identities = 80/254 (31%), Positives = 134/254 (52%), Gaps = 9/254 (3%)
Query: 3 EYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGK 62
++S G ALVTG S G+G+ + L + GA V +R +++QE+ G +V
Sbjct: 13 KWSLEGMTALVTGGSKGLGKAVVEELAMLGARVHTCARDETQLQESLREWQAKGLQVTTS 72
Query: 63 EVDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNING 121
DV+ E L++ + F G L LV N GI T + + + +I TN+
Sbjct: 73 VCDVSSRDQREKLMETVSSLFQGKLSILVPNVGIGVLKPT--TECTAEEFSFIIATNLES 130
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY 181
TF+ + A PL+++S S + +V +S+V G+V + S Y ATK A+ + +++A E+
Sbjct: 131 TFHFSQLAHPLLKASGSGN----IVLMSSVAGVVNLGNTSIYGATKGAMNQLARNLACEW 186
Query: 182 AERNVRVNAVAPGYVSTPKIQAL--PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLT 239
A N+R N+V P +++TP + K+ ++ + S P++R+ EVS+ V FL P
Sbjct: 187 ASDNIRANSVCPWFITTPSTKDFLGDKDVKEKVESVTPLRRVGEANEVSSLVAFLCLPAA 246
Query: 240 GFTTGSVYPIDGGF 253
+ TG +DGGF
Sbjct: 247 SYITGQTICVDGGF 260
>At2g29360 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 271
Score = 120 bits (300), Expect = 2e-27
Identities = 80/256 (31%), Positives = 133/256 (51%), Gaps = 15/256 (5%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S G ALVTG S G+GE + L GA + +R +++QE+ G +V
Sbjct: 14 WSLVGMTALVTGGSKGIGEAVVEELATLGARIHTCARDETQLQESLRKWQAKGFQVTTSV 73
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAG---ITGPHQTGIEDYDIDSWRQVIDTNI 119
DV+ E L++ + F G L+ LVNN G + Q ED+ + TN+
Sbjct: 74 CDVSSRDKREKLMETVSTIFEGKLNILVNNVGTCIVKPTLQHTAEDFSF-----TMATNL 128
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVAL 179
F+ + A PL+++S S ++V +S+V+G+V + G S Y +K A+ + +++A
Sbjct: 129 ESAFHLSQLAHPLLKASGS----GSIVLISSVSGVVHVNGASIYGVSKGAMNQLGRNLAC 184
Query: 180 EYAERNVRVNAVAPGYVSTPKI--QALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSP 237
E+A N+R N+V P ++ TP + +E ++ + S+ PM R+ + EVS+ V FL P
Sbjct: 185 EWASDNIRTNSVCPWFIETPLVTESLSNEEFRKEVESRPPMGRVGEVNEVSSLVAFLCLP 244
Query: 238 LTGFTTGSVYPIDGGF 253
+ TG +DGGF
Sbjct: 245 AASYITGQTICVDGGF 260
>At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 308
Score = 120 bits (300), Expect = 2e-27
Identities = 77/245 (31%), Positives = 126/245 (51%), Gaps = 19/245 (7%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVIT-SRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
+ ++TGAS G+G+ IA AL G V++ +R E +E A I+ G + I DV+
Sbjct: 78 VVVITGASRGIGKAIALALGKAGCKVLVNYARSAKEAEEVAKQIEEYGGQAITFGGDVSK 137
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
A V+ +++ +++G + +VNNAGIT T + W +VI N+ G F
Sbjct: 138 ATDVDAMMKTALDKWGTIDVVVNNAGIT--RDTLLIRMKQSQWDEVIALNLTGVFLC--- 192
Query: 129 ALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRV 188
++ ++N+S+V GL+G G + Y A K VI +++ A E A RN+ V
Sbjct: 193 ------------TQGRIINISSVVGLIGNIGQANYAAAKGGVISFSKTAAREGASRNINV 240
Query: 189 NAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFL-LSPLTGFTTGSVY 247
N V PG++++ L ++ ++ + P+ R EV+ V FL LSP + TG +
Sbjct: 241 NVVCPGFIASDMTAELGEDMEKKILGTIPLGRYGKAEEVAGLVEFLALSPAASYITGQAF 300
Query: 248 PIDGG 252
IDGG
Sbjct: 301 TIDGG 305
>Hs10337605 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 119 bits (298), Expect = 4e-27
Identities = 76/248 (30%), Positives = 123/248 (48%), Gaps = 7/248 (2%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
A K+ALVT ++ G+G IAR L GA VV++SR V + + G V G V
Sbjct: 13 ANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHV 72
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
A+ E L+ + G + LV+NA + P + D + W + +D N+
Sbjct: 73 GKAEDRERLVAMAVKLHGGIDILVSNAAVN-PFFGSLMDVTEEVWDKTLDINVKAPALMT 131
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
K +P ME +VV +S++ PG SPY +K A++G+T+++A+E A RN+
Sbjct: 132 KAVVPEMEKRGG----GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNI 187
Query: 187 RVNAVAPGYVST--PKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTG 244
RVN +APG + T ++ + KE ++ M ++R+ + + V FL S + TG
Sbjct: 188 RVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYITG 247
Query: 245 SVYPIDGG 252
+ GG
Sbjct: 248 ETVVVGGG 255
>At2g29150 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 119 bits (298), Expect = 4e-27
Identities = 85/254 (33%), Positives = 135/254 (52%), Gaps = 10/254 (3%)
Query: 2 SEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIG 61
S +S G ALVTG S G+GE + L + GA V +R +++QE G V
Sbjct: 12 SRWSLEGMTALVTGGSKGLGEAVVEELAMLGARVHTCARDETQLQERLREWQAKGFEVTT 71
Query: 62 KEVDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNIN 120
DV+ + E L++ + F G L+ LVNNAG TG + E Y + + ++ TN+
Sbjct: 72 SVCDVSSREQREKLMETVSSVFQGKLNILVNNAG-TGIIKPSTE-YTAEDYSFLMATNLE 129
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
F+ + A PL+++S S ++V +S+V GLV G S Y A+K A+ + +S+A E
Sbjct: 130 SAFHLSQIAHPLLKASGS----GSIVFMSSVAGLVH-TGASIYGASKGAMNQLGRSLACE 184
Query: 181 YAERNVRVNAVAPGYVSTPKIQAL--PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPL 238
+A N+RVN+V P ++TP + ++ ++ + + PM R+ EVS+ V FL P
Sbjct: 185 WASDNIRVNSVCPWVITTPLTSFIFSDEKLRKAVEDKTPMGRVGEANEVSSLVAFLCFPA 244
Query: 239 TGFTTGSVYPIDGG 252
+ TG +DGG
Sbjct: 245 ASYITGQTICVDGG 258
>At2g29290 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 119 bits (297), Expect = 5e-27
Identities = 80/252 (31%), Positives = 133/252 (52%), Gaps = 9/252 (3%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S G ALVTG + G+GE + L + GA V +R +++QE G +V
Sbjct: 5 WSLQGMNALVTGGTKGIGEAVVEELSILGARVHTCARDETQLQERLREWQEKGFQVTTSI 64
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
DV++ + E L++ + F G L+ LVNN G T +Y + + ++ TN++
Sbjct: 65 CDVSLREQREKLMETVSSLFQGKLNILVNNVGTLMLKPT--TEYTAEEFSFLMATNLDSA 122
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
F+ + A PL+++S S ++V +S++ G+V + S Y ATK A+ + +++A E+A
Sbjct: 123 FHISQLAHPLLKASGS----GSIVLMSSIAGVVHVGVGSIYGATKGAMNQLARNLACEWA 178
Query: 183 ERNVRVNAVAPGYVSTPKIQAL--PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
N+R NA+ P ++TP I L +E ++ + PM R+ EVS V FL P
Sbjct: 179 SDNIRTNAICPWLITTPLISDLLSVEEMKKEAEERTPMGRVGEANEVSPLVAFLCLPAAS 238
Query: 241 FTTGSVYPIDGG 252
+ TG V +DGG
Sbjct: 239 YITGQVICVDGG 250
>Hs15277342 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 261
Score = 117 bits (293), Expect = 2e-26
Identities = 77/251 (30%), Positives = 128/251 (50%), Gaps = 13/251 (5%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRV-------IGK 62
+ALVTGA +G+G ++ L GATV + QET + GS+
Sbjct: 13 LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72
Query: 63 EVDVTVAKAVEDLIQEIREEFGAL-HYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNING 121
+ DV+ A+A L+++++ F +V+ AGIT + D W +VI N+ G
Sbjct: 73 QADVSEARAARCLLEQVQACFSRPPSVVVSCAGIT--QDEFLLHMSEDDWDKVIAVNLKG 130
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY 181
TF + A + S+ S ++N+S++ G VG G + Y A+K VIG+TQ+ A E
Sbjct: 131 TFLVTQAAAQALVSNGCRGS---IINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL 187
Query: 182 AERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGF 241
+R N+V PG+++TP Q +P++ ++ PM + +V++ V FL S +G+
Sbjct: 188 GRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGY 247
Query: 242 TTGSVYPIDGG 252
TG+ + GG
Sbjct: 248 ITGTSVEVTGG 258
>7296705 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 117 bits (293), Expect = 2e-26
Identities = 79/255 (30%), Positives = 127/255 (48%), Gaps = 14/255 (5%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSR-VIGKE 63
SF K+ +VTGAS+G+G G + L G + I R+L ++ ETA I +G +
Sbjct: 3 SFKDKVIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVA 62
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
D+ V+ ++ + G + LVNNAGI IE+ ++ + +V++TN+ +
Sbjct: 63 ADINSESDVQGIVSATLAKHGRIDVLVNNAGIL--ELGSIENTSLEQFDRVMNTNVRSLY 120
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
P + + + +VN+S+VNG+ PG+ Y +K AV T+ VALE A
Sbjct: 121 QLTHLVTPELIKT-----KGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAP 175
Query: 184 RNVRVNAVAPGYVST--PKIQALPKETQ----QWMSSQHPMKRMATMTEVSNTVLFLLSP 237
+ VRVN+V PG + T + L +E + H + R + EV+ + FL S
Sbjct: 176 KGVRVNSVNPGVIITELQRRGGLDQEAYVKFLEHAKVTHALGRPGEVKEVAAAIAFLASD 235
Query: 238 LTGFTTGSVYPIDGG 252
F+TG P+DGG
Sbjct: 236 EASFSTGISLPVDGG 250
>CE09969 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 115 bits (288), Expect = 6e-26
Identities = 83/257 (32%), Positives = 128/257 (49%), Gaps = 21/257 (8%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAG-----NIDPSGSRV-IGK 62
++ALVT ++ G+G IA+ L GA+VV+ SR V E NID G+ +G
Sbjct: 12 RVALVTASTKGIGFAIAKQLGAAGASVVVCSRKKENVDEAVAALRLENIDAHGTTAHVGN 71
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
+ D T LI + F L LV+NA + PH + W +++D N+
Sbjct: 72 KSDRT------KLIDFTLDRFTKLDILVSNAAVN-PHYGDLMKVTDSQWDKLLDLNVKSA 124
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
F K A+P +E+S + VV +S+V G + I Y+ K + G+++S+AL A
Sbjct: 125 FELTKEAVPHLEASGRGN----VVFVSSVAGYSPMNEIGAYSVMKTTLTGLSKSLALNLA 180
Query: 183 ERNVRVNAVAPGYVSTPKIQAL---PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLT 239
RN+RVN++APG + T Q L E Q+W+ SQ +R E + V FL+S
Sbjct: 181 RRNIRVNSIAPGIIQTDFSQVLFSDESEKQKWL-SQIAQRRFGDPDECAEAVAFLVSDEA 239
Query: 240 GFTTGSVYPIDGGFLAQ 256
+ +G I+GG A+
Sbjct: 240 SYISGETIGINGGMHAR 256
>SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 114 bits (284), Expect = 2e-25
Identities = 81/249 (32%), Positives = 124/249 (49%), Gaps = 11/249 (4%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITS--RHLSEVQETAGNIDPSGSRVIGKEV 64
A K L+TG +G+G+ A G+ +VI+ + + T I+ G E
Sbjct: 41 AEKKTLLTGGDSGIGKAAAVMFAREGSDLVISCLPEERDDAEVTRDLIEREGRNCWIWEG 100
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
+ + DL+ ++ G + LVNN Q+ IED D + W TNI F+
Sbjct: 101 KLDKSDNCRDLVDFALKKLGWIDVLVNNIAYQQVAQS-IEDIDDEQWDLTFKTNIFSFFW 159
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER 184
K A+ M+S SS +VN S++N VG P + YT+TK A+ T+ ++ +YA+
Sbjct: 160 VTKAAISHMKSGSS------IVNCSSINAYVGRPDLLDYTSTKGAITAFTRGLSNQYAQH 213
Query: 185 NVRVNAVAPGYVSTPKIQA-LPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTT 243
+RVNAVAPG + TP + + PKE + +S Q P+ RM EV++ LFL G+ T
Sbjct: 214 GIRVNAVAPGPIYTPLVSSTFPKEKIE-LSDQVPLGRMGQPVEVASCYLFLACSDGGYMT 272
Query: 244 GSVYPIDGG 252
G +GG
Sbjct: 273 GQTLHPNGG 281
>At2g29350 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 111 bits (278), Expect = 9e-25
Identities = 79/253 (31%), Positives = 127/253 (49%), Gaps = 8/253 (3%)
Query: 2 SEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIG 61
S +S G ALVTG S G+GE + L + GA V +R +++QE G +V
Sbjct: 11 SRWSLGGMTALVTGGSKGIGEAVVEELAMLGAKVHTCARDETQLQERLREWQAKGFQVTT 70
Query: 62 KEVDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNIN 120
DV+ L++ + + G L+ LVNN G + T +Y + + V+ TN+
Sbjct: 71 SVCDVSSRDQRVKLMETVSSLYQGKLNILVNNVGTSIFKPT--TEYTAEDFSFVMATNLE 128
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
F+ + A PL+++S S ++V +S+ G+V + S Y ATK A+ + +++A E
Sbjct: 129 SAFHLSQLAHPLLKASGS----GSIVLISSAAGVVHVNVGSIYGATKGAMNQLARNLACE 184
Query: 181 YAERNVRVNAVAPGYVSTP-KIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLT 239
+A N+R N+V P Y++TP +E ++ PM R+ EVS V FL P
Sbjct: 185 WASDNIRTNSVCPWYITTPLSNDFFDEEFKKEAVRTTPMGRVGEANEVSPLVAFLCLPSA 244
Query: 240 GFTTGSVYPIDGG 252
+ TG +DGG
Sbjct: 245 SYITGQTICVDGG 257
>At1g07440 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 266
Score = 111 bits (278), Expect = 9e-25
Identities = 75/251 (29%), Positives = 124/251 (48%), Gaps = 8/251 (3%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S K LVTG + G+G I GA + +R+ E+ E G +V G
Sbjct: 10 WSLKAKTVLVTGGTKGIGHAIVEEFAGFGAVIHTCARNEYELNECLSKWQKKGFQVTGSV 69
Query: 64 VDVTVAKAVEDLIQEIREEFGA-LHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
D ++ E L+Q + FG L L+NN G T DY + + I TN+
Sbjct: 70 CDASLRPEREKLMQTVSSMFGGKLDILINNLGAIRSKPT--LDYTAEDFSFHISTNLESA 127
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
++ + A PL+++S + ++ +S++ G+V S Y+ATK A+ + +++A E+A
Sbjct: 128 YHLSQLAHPLLKASGCGN----IIFMSSIAGVVSASVGSIYSATKGALNQLARNLACEWA 183
Query: 183 ERNVRVNAVAPGYVSTPKIQAL-PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGF 241
+R NAVAP ++TP +A+ E ++ + S+ P+ R EVS+ V FL P +
Sbjct: 184 SDGIRANAVAPAVIATPLAEAVYDDEFKKVVISRKPLGRFGEPEEVSSLVAFLCMPAASY 243
Query: 242 TTGSVYPIDGG 252
TG +DGG
Sbjct: 244 ITGQTICVDGG 254
>At2g30670 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 110 bits (275), Expect = 2e-24
Identities = 73/252 (28%), Positives = 128/252 (49%), Gaps = 9/252 (3%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S G ALVTG ++G+G I L GA + + + + ++ + G +V G
Sbjct: 5 WSLQGMTALVTGGASGIGHAIVEELAGLGARIYVCDISETLLNQSLSEWEKKGFQVSGSI 64
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
DV+ E L+Q + + F G L+ LVNN G+ P T +Y + I TN+
Sbjct: 65 CDVSSHSERETLMQTVSKMFDGKLNILVNNVGVVNPKPT--IEYVAADFSFSISTNLESA 122
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
++ + + PL+++S +++ +S+V G+V + S Y+ TK A+ + +++A E+A
Sbjct: 123 YHLSQLSHPLLKASEF----GSIIFISSVGGVVSMECGSIYSLTKGALNQLAKTLACEWA 178
Query: 183 ERNVRVNAVAPGYVSTPKIQALPKET--QQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
+R N+VAP ++ T Q K+ ++ + S+ P+ R EVS+ V FL P
Sbjct: 179 RDGIRANSVAPNFIYTAMAQPFFKDADYEKSLVSRTPLGRAGEPNEVSSLVAFLCLPAAS 238
Query: 241 FTTGSVYPIDGG 252
+ TG +DGG
Sbjct: 239 YITGQTICVDGG 250
>At2g29340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 110 bits (275), Expect = 2e-24
Identities = 70/252 (27%), Positives = 132/252 (51%), Gaps = 9/252 (3%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S G ALVTG ++G+G I L GA + + +++ ++ + G +V G
Sbjct: 5 WSLKGMTALVTGGASGIGYAIVEELAGFGARIHVCDISEAKLNQSLSEWEKKGFQVSGSV 64
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
DV E+L+Q + +F G L+ LV+N G+ T +Y D + I +N+
Sbjct: 65 CDVASRPEREELMQTVSSQFDGKLNILVSNVGVIRSKPT--TEYTEDDFAFHISSNVEAA 122
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
++ + + PL+++S +++ +S++ G++ S Y TK A+I + +++A E+A
Sbjct: 123 YHFSQLSHPLLKASGY----GSIIFVSSIAGVISFDAGSIYGLTKGALIQLAKNLACEWA 178
Query: 183 ERNVRVNAVAPGYVSTPKIQALPKET--QQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
+ +R NAVAP ++TP Q+ ++ ++ + S+ P+ R+ EV++ V FL P
Sbjct: 179 KDGIRANAVAPNVINTPLSQSYLEDVSFKKALLSRTPLGRVGEPNEVASLVAFLCLPAAS 238
Query: 241 FTTGSVYPIDGG 252
+ TG +DGG
Sbjct: 239 YITGQTICVDGG 250
>At2g29310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 110 bits (274), Expect = 3e-24
Identities = 78/253 (30%), Positives = 130/253 (50%), Gaps = 9/253 (3%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S G ALVTGA++G+G I L GA + I + + ++ + G +V G
Sbjct: 5 WSLQGMTALVTGAASGIGYAIVEELASFGAIIHICDISETLLSQSLSEWEKKGFQVSGSI 64
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
DV E L+Q + F G L+ LVNN G+ T +Y + + I TN+
Sbjct: 65 CDVASRPDREKLMQTVSSLFDGKLNILVNNVGVIRGKPT--TEYVAEDFSYHISTNLEPA 122
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
F+ + + L+++S ++V +S+ G+V + S Y+ TK A+ +T+++A E+A
Sbjct: 123 FHFSQLSHLLLKASGF----GSIVFMSSATGVVSVQCGSIYSLTKGALNQLTRNLACEWA 178
Query: 183 ERNVRVNAVAPGYVSTPKIQALPKET--QQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
+ +R NAVAP V TP Q+ ++ ++ + S+ P+ R EV++ V+FL P
Sbjct: 179 KDGIRANAVAPNVVKTPLSQSYLEDVGFKEALFSRTPLGRAGEPNEVASLVVFLCLPAAS 238
Query: 241 FTTGSVYPIDGGF 253
+ TG IDGGF
Sbjct: 239 YITGQTICIDGGF 251
>At2g29320 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 109 bits (272), Expect = 4e-24
Identities = 79/253 (31%), Positives = 131/253 (51%), Gaps = 10/253 (3%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S G ALVTGA++G+G I L GA + I + + ++ + G +V G
Sbjct: 11 WSLQGMTALVTGAASGIGYAIVEELAGFGAKIHICDISKTLLNQSLSEWENKGFQVSGSV 70
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
DVT E L+Q + F G L+ LVNN G+ T +Y D + I TN+
Sbjct: 71 CDVTSHPEREKLMQTVSSIFDGKLNILVNNVGVLRGKPT--TEYVADDFTFHISTNLEAA 128
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGI-SPYTATKHAVIGITQSVALEY 181
++ + + PL+++S ++V LS+V G+V + S Y TK A+ + +++A E+
Sbjct: 129 YHFCQLSHPLLKAS----GYGSIVFLSSVAGVVSLIDCGSIYGLTKGALNQLARNLACEW 184
Query: 182 AERNVRVNAVAPGYVSTPKIQALPKET--QQWMSSQHPMKRMATMTEVSNTVLFLLSPLT 239
A+ +R NAVAP V T + Q+ ++ ++ + S+ P+ R+ EVS+ V+FL P
Sbjct: 185 AKDGIRANAVAPNVVKTAQSQSFLEDVSKKEGLLSRTPLGRVGEPNEVSSLVVFLCLPAA 244
Query: 240 GFTTGSVYPIDGG 252
+ TG +DGG
Sbjct: 245 SYITGQTICVDGG 257
>At2g29300 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 263
Score = 109 bits (272), Expect = 4e-24
Identities = 83/258 (32%), Positives = 132/258 (50%), Gaps = 20/258 (7%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGN-----IDPSGSR 58
+S G ALVTGA++G+G I L GA + H+ ++ ET N + G +
Sbjct: 5 WSLQGMTALVTGAASGIGYAIVEELAGFGARI-----HVCDISETLLNQSLREWEKKGFQ 59
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDT 117
V G DVT E L+Q + F G L+ LVNN G+ T +Y D + I T
Sbjct: 60 VSGSVCDVTSRPEREKLMQTVSSLFDGKLNILVNNVGVLRAKPT--TEYVADDFTFHIST 117
Query: 118 NINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGI-SPYTATKHAVIGITQS 176
N+ ++ + + PL+++S ++V LS+V+G+V I S Y TK A+ + ++
Sbjct: 118 NLEAAYHFCQLSHPLLKTS----GYGSIVFLSSVSGVVSITDCGSLYGLTKGALNQLARN 173
Query: 177 VALEYAERNVRVNAVAPGYVSTPKIQALPKET--QQWMSSQHPMKRMATMTEVSNTVLFL 234
+A E+A+ +R NAVAP V T + Q ++ ++ + S+ P+ R EV++ V+FL
Sbjct: 174 LACEWAKDGIRANAVAPNVVKTAQSQFFLQDVSKKEGLFSRTPLGRSGEPNEVASLVVFL 233
Query: 235 LSPLTGFTTGSVYPIDGG 252
P + TG IDGG
Sbjct: 234 CLPAASYITGQTICIDGG 251
>At1g54870 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 108 bits (271), Expect = 6e-24
Identities = 78/253 (30%), Positives = 125/253 (48%), Gaps = 16/253 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVIT------SRHLSEVQETAGNIDPSGSRV-IG 61
++AL+TG +G+G + GATV T + E + + S S+ I
Sbjct: 36 RVALITGGDSGIGRAVGYCFASEGATVAFTYVKGQEEKDAQETLQMLKEVKTSDSKEPIA 95
Query: 62 KEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNING 121
D+ + + ++ E+ FG + L+NNA T IE+ D +V TNI
Sbjct: 96 IPTDLGFDENCKRVVDEVVNAFGRIDVLINNAAEQYESST-IEEIDEPRLERVFRTNIFS 154
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY 181
F+ ++AL M+ SS ++N ++VN G + YTATK A++ T+ +AL+
Sbjct: 155 YFFLTRHALKHMKEGSS------IINTTSVNAYKGNASLLDYTATKGAIVAFTRGLALQL 208
Query: 182 AERNVRVNAVAPGYVSTPKIQA-LPKETQQWMSSQHPMKRMATMTEVSNTVLFL-LSPLT 239
AE+ +RVN VAPG + TP I A +E + S+ PMKR EV+ + +FL + +
Sbjct: 209 AEKGIRVNGVAPGPIWTPLIPASFNEEKIKNFGSEVPMKRAGQPIEVAPSYVFLACNHCS 268
Query: 240 GFTTGSVYPIDGG 252
+ TG V +GG
Sbjct: 269 SYFTGQVLHPNGG 281
>Hs14754051 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 245
Score = 108 bits (270), Expect = 7e-24
Identities = 72/252 (28%), Positives = 124/252 (48%), Gaps = 20/252 (7%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
GK+ ++T A+ G+G+ A A GA V+ T ++S++QE + + + +DVT
Sbjct: 6 GKVIILTAAAQGIGQAAALAFVREGAKVIATDINVSKLQELEKYLG-----IQTRVLDVT 60
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
K ++ E+ L L N AG H + D + W ++ N+ T+ +K
Sbjct: 61 KKKQIDQFANEVER----LDVLFNVAGFV--HHGTVLDCEEKDWDFSMNLNVRSTYLMIK 114
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVR 187
LP M + S + + S V+ + G+ Y+ TK AVIG+T+SVA ++ ++ +R
Sbjct: 115 AFLPKMLAQKSGN---IITMFSVVSSIKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIR 171
Query: 188 VNAVAPGYVSTPKIQ------ALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGF 241
N V PG V TP +Q P+E + + M R AT E++ +++ S + +
Sbjct: 172 CNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKMGRFATAEEIAMLCVYVASDESAY 231
Query: 242 TTGSVYPIDGGF 253
TG+ IDGG+
Sbjct: 232 VTGNPVIIDGGW 243
>7290108 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 107 bits (267), Expect = 2e-23
Identities = 64/191 (33%), Positives = 109/191 (56%), Gaps = 11/191 (5%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV 64
S + K+ +VTGAS+G+G IA+ L GAT+ + R+++ ++ T ++ + + ++ +
Sbjct: 2 SLSNKVVIVTGASSGIGAAIAQVLAREGATLALVGRNVANLEATKKSLKGTQAEIVVAD- 60
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
V K + ++Q+ +FG + LVNNAGI G + G+ D DI+ + V++TN+ G
Sbjct: 61 ---VTKDADAIVQQTLAKFGRIDVLVNNAGILG--KGGLIDLDIEEFDAVLNTNLRGVIL 115
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER 184
K LP + ++ AVVN+S+ G+ G Y +K A+ T+ VALE A +
Sbjct: 116 LTKAVLPHLLK-----TKGAVVNVSSCAGIRPFAGALSYGVSKAALDQFTKIVALEMAPQ 170
Query: 185 NVRVNAVAPGY 195
VRVN+V PG+
Sbjct: 171 GVRVNSVNPGF 181
>7296704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 106 bits (265), Expect = 3e-23
Identities = 76/255 (29%), Positives = 120/255 (46%), Gaps = 16/255 (6%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVD 65
F+GK+ L+TGA++G+G A GA + + R + G G D
Sbjct: 11 FSGKVVLITGAASGIGAAAAEMFSKLGACLALVDREEEGLICVMKRCMKMGHEPYGIAGD 70
Query: 66 VTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTG-IEDYDIDSWRQVIDTNINGTF 123
+ +E + ++ E + G L LVN AGI TG ++ ++ + V++ N+ F
Sbjct: 71 LLKPPEIECIARKTTERYEGKLDVLVNGAGIM---PTGTLQSTELACFTHVMEANVRSGF 127
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
Y K LP + + ++VN+S+V GL P + Y +K AV T+S+AL+
Sbjct: 128 YLTKLLLPQLLQC-----KGSIVNVSSVCGLRAFPNLVAYNMSKAAVDQFTRSLALDLGP 182
Query: 184 RNVRVNAVAPGYVSTPKIQALPKETQQW------MSSQHPMKRMATMTEVSNTVLFLLSP 237
+ VRVNAV PG + T +A + Q + H + R+ EV+ + FL S
Sbjct: 183 QGVRVNAVNPGVIRTNLQKAGGMDEQSYAEFLEHSKKTHALGRIGEPKEVAAAICFLASE 242
Query: 238 LTGFTTGSVYPIDGG 252
L F TG P+DGG
Sbjct: 243 LASFVTGVTLPVDGG 257
>At3g55310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 298
Score = 106 bits (264), Expect = 4e-23
Identities = 74/254 (29%), Positives = 131/254 (51%), Gaps = 16/254 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDP---SGSRVIGKEVD 65
K+ LVTGAS+G+G I L G V+ +R + + I+ +G + E+D
Sbjct: 39 KVVLVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQAAALELD 98
Query: 66 VTV-AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
V+ A ++ ++E + FG + L+NNAGI G + + D D W V +TN+ G +
Sbjct: 99 VSSDAATIQKAVREAWDIFGKIDALINNAGIRGNVKLSL-DLSEDEWDNVFNTNLKGPWL 157
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGI-PGISPYTATKHAVIGITQSVALEYAE 183
KY LM + S V+N+S+V G+ I PG Y+ +K V +++ +A+E
Sbjct: 158 VAKYVCVLMRDAKRGGS---VINISSVAGVRSIVPGGLAYSCSKGGVDTMSRMMAIELGV 214
Query: 184 RNVRVNAVAPGYVSTPKIQALPKETQQWMSS----QHPMKRMATMTE-VSNTVLFLLSPL 238
+RVN++APG + QAL + ++W+ + P+K T+ +++ V +L+
Sbjct: 215 HKIRVNSIAPGLFKSEITQALMQ--KEWLKNVTERTVPLKVQQTIDPGLTSLVRYLIHDS 272
Query: 239 TGFTTGSVYPIDGG 252
+ + +G+ Y +D G
Sbjct: 273 SQYISGNTYIVDSG 286
>SPAC922.06 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 105 bits (263), Expect = 5e-23
Identities = 71/252 (28%), Positives = 122/252 (48%), Gaps = 20/252 (7%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVV-ITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
G++ L+TGA+ G+G+ + + G V I S+VQ+ A + + DV
Sbjct: 5 GRVVLITGAAGGIGKVLCKMFTELGDRVAGIDIVDPSKVQDAA----------LALQADV 54
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
+ A +E I+++ + G + L+NNAG+ T E +SW + + G + T
Sbjct: 55 SKADQIETAIEKVIQTLGPIDVLINNAGLAD--DTPFEQLSHESWDHDVSLVLRGNYLTQ 112
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
+Y +P M S +VN+ +VNG + + G Y+A K + +T+++A+ Y +
Sbjct: 113 RYVIPHMAKQGKGGS---IVNIGSVNGHIYL-GSPAYSAAKAGLENLTKALAVRYGPLGI 168
Query: 187 RVNAVAPGYVSTPKIQALPK---ETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTT 243
RVN APG + +P K + M +P+ R+ T +V+ V+FL F T
Sbjct: 169 RVNVCAPGTIWSPAWDERFKKHPDVGDRMKRWYPVGRLGTPEDVARAVIFLADSKNSFIT 228
Query: 244 GSVYPIDGGFLA 255
G+ +DGG LA
Sbjct: 229 GTTLYVDGGLLA 240
>Hs5031737 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 105 bits (262), Expect = 6e-23
Identities = 69/247 (27%), Positives = 115/247 (45%), Gaps = 8/247 (3%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
A ++A+VTG+++G+G IAR L GA VVI+SR V + G V G V
Sbjct: 35 ANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHV 94
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
A+ E L+ + E G + +LV +AG+ P W +++ N+ L
Sbjct: 95 GKAEDREQLVAKALEHCGGVDFLVCSAGV-NPLVGSTLGTSEQIWDKILSVNVKSPALLL 153
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
LP ME + AV+ +S++ + + Y +K A++G+T+++ALE A +++
Sbjct: 154 SQLLPYME-----NRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDI 208
Query: 187 RVNAVAPGYVSTPKIQALPKETQQW--MSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTG 244
RVN V PG + T + W H ++R+ + + V FL SP + G
Sbjct: 209 RVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNG 268
Query: 245 SVYPIDG 251
+ G
Sbjct: 269 ENIAVAG 275
>CE19894 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 105 bits (261), Expect = 8e-23
Identities = 73/257 (28%), Positives = 125/257 (48%), Gaps = 11/257 (4%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG-SRVIGKEV 64
F GK+A+VT A+ G+G IA L GA+VVI SR+ V E + G ++V G
Sbjct: 8 FEGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAG 67
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
+ + L+ ++FG ++ LVNN GI P I + W ++ + N+ F
Sbjct: 68 HIASTDDQKKLVDFTLQKFGKINILVNNHGIN-PAFGHILEVSDQVWDKLFEVNVKAGFQ 126
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER 184
K P + + + A++ ++ + PGI+ Y TK ++G+T+++A+ A+
Sbjct: 127 MTKLVHPHI----AKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKD 182
Query: 185 NVRVNAVAPGYVSTPKIQAL-----PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLT 239
N+RVN +APG + T Q L E + + + R+ + + TV +L S +
Sbjct: 183 NIRVNGIAPGVIKTKMSQVLWDGGEDAEKELTDIQEIALGRLGVPDDCAGTVAYLASDDS 242
Query: 240 GFTTGSVYPIDGGFLAQ 256
+ TG + I GG A+
Sbjct: 243 SYITGEMIIIAGGVQAR 259
>At1g63380 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 287
Score = 105 bits (261), Expect = 8e-23
Identities = 73/255 (28%), Positives = 132/255 (51%), Gaps = 17/255 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS---RVIGKEVD 65
K+ LVTGAS+G+G I L G +V +R + + I+ G+ + + E+D
Sbjct: 25 KVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAVALELD 84
Query: 66 V-TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
V + A + ++E E FG + L+NNAGI G ++ + D + W +V TN+ G++
Sbjct: 85 VSSEADTIRKAVKEAWETFGKIDVLINNAGIRGNVKSSL-DLSEEEWDKVFRTNLTGSWL 143
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVG--IPGISPYTATKHAVIGITQSVALEYA 182
KY LM + + +V+N+S+++GL + G Y +K V +T+ +A+E A
Sbjct: 144 ISKYVCLLMRDA---ERGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELA 200
Query: 183 ERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQH----PMKRMATMTE-VSNTVLFLLSP 237
+RVN++APG + Q L + ++W+ P+K T+ +++ V +L+
Sbjct: 201 VYKIRVNSIAPGIFRSEITQGLFQ--KEWLKKVTEKVVPLKMQQTVDPGLTSLVRYLIHD 258
Query: 238 LTGFTTGSVYPIDGG 252
+ + TG+ Y +D G
Sbjct: 259 SSQYVTGNTYIVDSG 273
>At2g47120 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 104 bits (259), Expect = 1e-22
Identities = 77/263 (29%), Positives = 131/263 (49%), Gaps = 23/263 (8%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVI 60
MS GKI ++TG ++G+G AR GA VVI +VQE G + + +I
Sbjct: 1 MSGLRLEGKIVIITGGASGIGADAARLFTDHGAKVVIV-----DVQEELGQ---NVAVLI 52
Query: 61 GKE------VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQV 114
GK+ DVT VED ++ E+ G L L +NAG+ P ++ + D+D++ + ++
Sbjct: 53 GKDKASFYRCDVTNETEVEDAVKFTVEKHGKLDVLFSNAGVLEPLESFL-DFDLERFDRI 111
Query: 115 IDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGIT 174
+ N+ G +K+A M + S ++SA G G YTA+KH ++G+
Sbjct: 112 MAVNVRGAAAFIKHAARAMVEKGTRGSIVCTTSVSAEIG----GGHHGYTASKHGLVGLI 167
Query: 175 QSVALEYAERNVRVNAVAPGYVSTPKI---QALPKETQQWMSSQHPMKRMA-TMTEVSNT 230
+S + + +RVN VAP V+TP + K+ + + ++ +K M + V+
Sbjct: 168 RSACGDLGKYGIRVNGVAPYAVATPMTSHDEVTGKQLEDYFDAKGILKGMVLKASHVAQV 227
Query: 231 VLFLLSPLTGFTTGSVYPIDGGF 253
LFL S + + +G +DGG+
Sbjct: 228 ALFLASDDSAYISGQNLAVDGGY 250
>At3g46170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 288
Score = 103 bits (257), Expect = 2e-22
Identities = 72/254 (28%), Positives = 128/254 (50%), Gaps = 16/254 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPS---GSRVIGKEVD 65
K+ LVTGAS+G+G I L G ++ +R + + I+ S G + ++D
Sbjct: 29 KVVLVTGASSGIGREICLDLGKAGCKIIAVARRVDRLNSLCSEINSSSSTGIQAAALKLD 88
Query: 66 VTV-AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
VT A ++ ++Q FG + L+NNAGI G ++ + D + W V TN+ G +
Sbjct: 89 VTSDAATIQKVVQGAWGIFGKIDALINNAGIRGNVKSSL-DLSKEEWDNVFKTNLTGPWL 147
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGI-PGISPYTATKHAVIGITQSVALEYAE 183
KY LM + S V+N+S++ G+ GI PG Y +K V +++ +A+E
Sbjct: 148 VSKYVCVLMRDAKLGGS---VINISSIAGIRGILPGALAYACSKIGVDTMSKMMAVELGV 204
Query: 184 RNVRVNAVAPGYVSTPKIQALPKETQQWMSS----QHPMKRMATMTE-VSNTVLFLLSPL 238
+RVN++APG + Q L + ++W + P+K T+ +++ V +L+
Sbjct: 205 HKIRVNSIAPGIFKSEITQGLMQ--KEWFKNVTERTVPLKLQQTVDPGITSLVRYLIHDS 262
Query: 239 TGFTTGSVYPIDGG 252
+ + +G+ Y +D G
Sbjct: 263 SQYISGNTYIVDSG 276
>7296706_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 233
Score = 103 bits (257), Expect = 2e-22
Identities = 73/229 (31%), Positives = 117/229 (50%), Gaps = 16/229 (6%)
Query: 32 GATVVITSRHLSEVQETAGNIDPSGSRV-IGKEVDVTVAKAVEDLIQEIREEFGALHYLV 90
G +VI R+ +++ETA NI +G + + D+T V+ ++ + G + LV
Sbjct: 6 GGLLVIVGRNEEKLKETADNIVAAGGATPLELQADMTKEAEVQQIVGATLAKHGRIDVLV 65
Query: 91 NNAGITGPHQTG-IEDYDIDSWRQVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLS 149
NNAGI +TG IE ++ + ++++TN+ Y L ++ + ++ +VN+S
Sbjct: 66 NNAGIL---ETGSIEATSLEQFDRLMNTNVRSL-----YQLTMLATPELVKTKGNIVNVS 117
Query: 150 AVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRVNAVAPGYVSTP--KIQALPKE 207
+V GL PG+ Y +K AV T +ALE A + VRVNAV PG + T K + +E
Sbjct: 118 SVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNPGVIVTDIHKRGGMDEE 177
Query: 208 TQ----QWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTGSVYPIDGG 252
T + H + R + EV+ + FL S FTTG P+DGG
Sbjct: 178 TYAKFLEHCKITHALGRPGDVKEVAAAIAFLASDQASFTTGISLPVDGG 226
>At2g29330 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 103 bits (256), Expect = 3e-22
Identities = 69/252 (27%), Positives = 125/252 (49%), Gaps = 9/252 (3%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S G ALVTG ++G+G I L GA + + + + ++ + G +V G
Sbjct: 5 WSLQGLTALVTGGASGIGHAIVEELAGFGAKIHVCDISKTLLNQSLSEWEKKGFQVSGSV 64
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
D + E L+Q + F G L+ LVNN G T +Y+ + + +I TN+
Sbjct: 65 CDASNRLERETLMQTVTTIFDGKLNILVNNVGTIRTKPT--IEYEAEDFSFLISTNLESA 122
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
++ + + PL+++S + + +S+ G+V S Y TK A+ + +++A E+A
Sbjct: 123 YHLSQLSHPLLKASGN----GIITFISSAAGIVSFDAASIYGLTKGALNQLARNLACEWA 178
Query: 183 ERNVRVNAVAPGYVSTPKIQALPKET--QQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
+ +R NAVAP +++T + ++ + +SS+ P+ R EV++ V FL P
Sbjct: 179 KDGIRANAVAPNFITTALAKPFLEDAGFNEILSSRTPLGRAGEPREVASLVAFLCLPAAS 238
Query: 241 FTTGSVYPIDGG 252
+ TG +DGG
Sbjct: 239 YITGQTICVDGG 250
>At1g62610 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 307
Score = 103 bits (256), Expect = 3e-22
Identities = 74/255 (29%), Positives = 130/255 (50%), Gaps = 17/255 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS---RVIGKEVD 65
K+ LVTGAS+G+G I L G +V +R + + I+ G+ + E+D
Sbjct: 47 KVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAAALELD 106
Query: 66 VTV-AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
V+ A + ++E E FG + L+NNAGI G ++ + D + W +V TN+ G++
Sbjct: 107 VSSDADTIRKAVKEAWEIFGTIDVLINNAGIRGNVKSSL-DLSKEEWDKVFRTNLTGSWL 165
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVG--IPGISPYTATKHAVIGITQSVALEYA 182
KY LM + S V+N+S+++GL + G Y +K V +T+ +A+E A
Sbjct: 166 ISKYVCLLMRDAKRGGS---VINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELA 222
Query: 183 ERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQH----PMKRMATMTE-VSNTVLFLLSP 237
+RVN++APG + Q L + ++W+ P+K T+ +++ V +L+
Sbjct: 223 VYKIRVNSIAPGIFRSEITQGLFQ--KEWLEKVTEKIVPLKMQQTVDPGLTSLVRYLIHD 280
Query: 238 LTGFTTGSVYPIDGG 252
+ + TG+ Y +D G
Sbjct: 281 SSQYVTGNTYIVDSG 295
>7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 255
Score = 103 bits (256), Expect = 3e-22
Identities = 72/254 (28%), Positives = 135/254 (52%), Gaps = 22/254 (8%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVA 69
++LVTG ++G+G A L +GA+V++ S+ E A + G +V+ VDVT
Sbjct: 6 VSLVTGGASGLGRATAERLAKQGASVILADLPSSKGNEVAKEL---GDKVVFVPVDVTSE 62
Query: 70 KAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYD--------IDSWRQVIDTNING 121
K V +Q +++FG L VN AG T ++ ++ ++ +++VI+ N G
Sbjct: 63 KDVSAALQTAKDKFGRLDLTVNCAGTA----TAVKTFNFNKNVAHRLEDFQRVININTVG 118
Query: 122 TFYTLKYALPLMESS--SSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVAL 179
TF ++ + LM ++ + +VN ++V G G + Y+A+K AV+G+T +A
Sbjct: 119 TFNVIRLSAGLMGANEPNQDGQRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMTLPIAR 178
Query: 180 EYAERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPM-KRMATMTEVSNTVLFLL-SP 237
+ + + +R+ +APG +TP + ALP++ + +++ P +R+ +E ++ V + +P
Sbjct: 179 DLSTQGIRICTIAPGLFNTPMLAALPEKVRTFLAKSIPFPQRLGEPSEYAHLVQAIYENP 238
Query: 238 LTGFTTGSVYPIDG 251
L G V IDG
Sbjct: 239 L---LNGEVIRIDG 249
>Hs10190704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 292
Score = 102 bits (255), Expect = 4e-22
Identities = 73/248 (29%), Positives = 125/248 (49%), Gaps = 10/248 (4%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-DPSGSRVIGKEVDVT 67
K+A +TG +G+G IA G VI SR L V A + +G R + +DV
Sbjct: 29 KVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVR 88
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
AV + + +EFG + L+N A G ++++ V+D + +GTF +
Sbjct: 89 APPAVMAAVDQALKEFGRIDILINCAA--GNFLCPAGALSFNAFKTVMDIDTSGTFNVSR 146
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVR 187
++ D +VN++A G G + K AV +T+ +A+E+ +N+R
Sbjct: 147 ----VLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIR 202
Query: 188 VNAVAPGYVS-TPKIQAL--PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTG 244
VN++APG +S T ++ L P+ + + P++R+ TE++++VL+L SPL + TG
Sbjct: 203 VNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTG 262
Query: 245 SVYPIDGG 252
+V DGG
Sbjct: 263 AVLVADGG 270
>Hs10047132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 245
Score = 102 bits (254), Expect = 5e-22
Identities = 73/253 (28%), Positives = 123/253 (47%), Gaps = 22/253 (8%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
GK+ ++T A+ G+G+ A A GA V+ T + S++QE + + +DVT
Sbjct: 6 GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELE-----KYPGIQTRVLDVT 60
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
K ++ E+ L L N AG H + D + W ++ N+ + +K
Sbjct: 61 KKKQIDQFANEVER----LDVLFNVAGFV--HHGTVLDCEEKDWDFSMNLNVRSMYLMIK 114
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLV-GIPGISPYTATKHAVIGITQSVALEYAERNV 186
LP M + S + ++N+S+V V G+ Y+ TK AVIG+T+SVA ++ ++ +
Sbjct: 115 AFLPKMLAQKSGN----IINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGI 170
Query: 187 RVNAVAPGYVSTPKIQ------ALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
R N V PG V TP +Q P+E + + R AT E++ ++L S +
Sbjct: 171 RCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESA 230
Query: 241 FTTGSVYPIDGGF 253
+ TG+ IDGG+
Sbjct: 231 YVTGNPVIIDGGW 243
>Hs4503301 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 335
Score = 102 bits (253), Expect = 7e-22
Identities = 71/253 (28%), Positives = 127/253 (50%), Gaps = 11/253 (4%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-DPSGSRVIGKE 63
SF GK+A +TG TG+G+G+ L GA VI SR + ++ TA I +G++V +
Sbjct: 56 SFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQ 115
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT- 122
DV V++ + E+ + G + ++NNA G + E ++W+ + D +NGT
Sbjct: 116 CDVRDPDMVQNTVSELIKVAGHPNIVINNA--AGNFISPTERLSPNAWKTITDIVLNGTA 173
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
F TL+ L+++ AA ++++ + G + P + K V +++S+A E+
Sbjct: 174 FVTLEIGKQLIKAQKG----AAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWG 229
Query: 183 ERNVRVNAVAPGYVSTPKIQALPKET---QQWMSSQHPMKRMATMTEVSNTVLFLLSPLT 239
+ +R N + PG + T + T ++ M + P R+ T+ E++N FL S
Sbjct: 230 KYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYA 289
Query: 240 GFTTGSVYPIDGG 252
+ G+V DGG
Sbjct: 290 SWINGAVIKFDGG 302
>CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 258
Score = 102 bits (253), Expect = 7e-22
Identities = 67/219 (30%), Positives = 110/219 (49%), Gaps = 11/219 (5%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV 64
S G +ALVTG ++G+G+G A L GA V I S+ + A I I
Sbjct: 6 STKGLVALVTGGASGLGKGAAEVLAKAGAQVAILDLPQSKGADVAKEIGG-----IFTPA 60
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGI----EDYDIDSWRQVIDTNIN 120
VT + V +++ E+G L LVN AGI + + D + RQ ID N+
Sbjct: 61 SVTSEEEVRAAFAKVQAEYGRLDALVNCAGIAYAFKLYSVQKKKHVDFEKIRQTIDVNVL 120
Query: 121 GTFYTLKYALPLM--ESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA 178
GTF +++ + LM + V+N ++V G G S Y+A+K A++G+T +A
Sbjct: 121 GTFNVIRHGVALMGEHEKDANGQRGVVINTASVAAFDGQTGQSAYSASKGAIVGMTLPLA 180
Query: 179 LEYAERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHP 217
++A +R N +APG + TP + +LP++ + +++ P
Sbjct: 181 RDFAGDGIRFNTIAPGLMDTPLLSSLPEKVKSFLAQLIP 219
>At3g26770 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 101 bits (252), Expect = 9e-22
Identities = 78/263 (29%), Positives = 123/263 (46%), Gaps = 26/263 (9%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
GK+AL+TG ++G+G+ A GA VVI +TA + GS DVT
Sbjct: 17 GKVALITGGASGLGKATASEFLRHGARVVIADLDAETGTKTAKEL---GSEAEFVRCDVT 73
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQ-TGIEDYDIDSWRQVIDTNINGTFYTL 126
V + ++ E +G L + NNAGI GP I D+ + +V+ N+ G +
Sbjct: 74 VEADIAGAVEMTVERYGKLDVMYNNAGIVGPMTPASISQLDMTEFERVMRINVFGVVSGI 133
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP--YTATKHAVIGITQSVALEYAER 184
K+A M P ++ S+V G+ G G++P YT +K GI +S A E E
Sbjct: 134 KHAAKFM----IPARSGCILCTSSVAGVTG--GLAPHSYTISKFTTPGIVKSAASELCEH 187
Query: 185 NVRVNAVAPGYVSTPKI-----QALPKETQQWMSSQHPMKRMATM-------TEVSNTVL 232
VR+N ++PG V+TP + PK +++ + + +K M + +V+ L
Sbjct: 188 GVRINCISPGTVATPLTLSYLQKVFPKVSEEKL--RETVKGMGELKGAECEEADVAKAAL 245
Query: 233 FLLSPLTGFTTGSVYPIDGGFLA 255
+L S + TG +DGG A
Sbjct: 246 YLASNDGKYVTGHNLVVDGGMTA 268
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 101 bits (251), Expect = 1e-21
Identities = 76/264 (28%), Positives = 128/264 (47%), Gaps = 23/264 (8%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
FA K+A++TG+S G+G A GA V IT RH ++ET I +G V
Sbjct: 4 FAEKVAIITGSSNGIGRATAVLFAREGAKVTITGRHAERLEETRQQILAAGVSEQNVNSV 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGP---HQTGIEDYDIDSWRQVIDTNI 119
DVT ++++ +FG L LVNNAG P +TG I+S+ ++ N+
Sbjct: 64 VADVTTDAGQDEILSTTLGKFGKLDILVNNAGAAIPDSQSKTGTAQ-SIESYDATLNLNL 122
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAV-NGLVGIPGISPYTATKHAVIGITQSVA 178
K A+P + S ++ +VN+S++ +GL P Y+ K A+ T++ A
Sbjct: 123 RSVIALTKKAVPHLSS-----TKGEIVNISSIASGLHATPDFPYYSIAKAAIDQYTRNTA 177
Query: 179 LEYAERNVRVNAVAPGYVST--PKIQALPKET-QQWMSSQHPMKR------MATMTEVSN 229
++ + +RVN+++PG V+T +P+ET +++ S+ MK M +++
Sbjct: 178 IDLIQHGIRVNSISPGLVATGFGSAMGMPEETSKKFYSTMATMKECVPAGVMGQPQDIAE 237
Query: 230 TVLFLLSPLT-GFTTGSVYPIDGG 252
+ FL T + G +DGG
Sbjct: 238 VIAFLADRKTSSYIIGHQLVVDGG 261
>At1g07450 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 100 bits (249), Expect = 2e-21
Identities = 84/265 (31%), Positives = 131/265 (48%), Gaps = 28/265 (10%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVI 60
++ +S G ALVTG S G+G I L GA V H+ ++ ET N SG
Sbjct: 3 INRWSLQGMTALVTGGSKGIGYAIVEELVGFGARV-----HICDIDETLLNECLSGWHAK 57
Query: 61 GKEV-----DVTVAKAVEDLIQEIREEFGA-LHYLVNNAG---ITGPHQTGIEDYDIDSW 111
G EV DV+ L+Q + FGA L+ L+NN G + ++ ED+
Sbjct: 58 GFEVSGSICDVSSRPQRVQLMQTVSSLFGAKLNILINNVGKYILKPTLESTAEDFS---- 113
Query: 112 RQVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP-YTATKHAV 170
++ TN+ +Y + A PL+++S + + +V +S+V G+V G S Y TK A+
Sbjct: 114 -SLMATNLESAYYISQLAHPLLKASGNGN----IVFISSVTGVVS--GTSTIYGVTKGAL 166
Query: 171 IGITQSVALEYAERNVRVNAVAPGYVSTPKIQALPKET--QQWMSSQHPMKRMATMTEVS 228
+ + +A E+A N+R N+VAP +T +Q ++ + M S+ P+ R EV+
Sbjct: 167 NQLARDLACEWASDNIRANSVAPWVTATSLVQKYLEDEIFAEAMFSRTPLGRACEPREVA 226
Query: 229 NTVLFLLSPLTGFTTGSVYPIDGGF 253
+ V FL P + TG IDGGF
Sbjct: 227 SLVTFLCLPAASYITGQTICIDGGF 251
>CE21093 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 281
Score = 99.0 bits (245), Expect = 6e-21
Identities = 75/263 (28%), Positives = 125/263 (47%), Gaps = 21/263 (7%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+GK+ALVTG+S G+G A GA V +T R+ ++ET I SG S V+
Sbjct: 5 FSGKVALVTGSSNGIGRAAAVLFAKDGAKVTVTGRNAERLEETRQEILKSGVPESHVLSV 64
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGI--EDYDIDSWRQVIDTNIN 120
D+ K ++L+ ++FG L LVNNAG G D D+ + +++ N+
Sbjct: 65 ATDLAAEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDKIMQINMR 124
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLV-GIPGISPYTATKHAVIGITQSVAL 179
L ++ +VN+S++ G PG+ Y +K A+ T+ A+
Sbjct: 125 SV-----VTLTQKAKEHLVKAKGEIVNVSSIAGTAHAQPGVMYYAMSKSALDQFTRCAAI 179
Query: 180 EYAERNVRVNAVAPGYVSTPKIQALP------KETQQWMSSQH---PMKRMATMTEVSNT 230
+ + VRVN+V+PG V+T +A+ +E ++M S+ P +A +++N
Sbjct: 180 DLIQYGVRVNSVSPGGVTTGFGEAMGMPSGAFEEMMKFMESRKECIPSGAVAKPIDIANI 239
Query: 231 VLFLLS-PLTGFTTGSVYPIDGG 252
+ FL L+ + G DGG
Sbjct: 240 IAFLADRKLSSYIIGQSIVADGG 262
>SPAC8E11.10 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 255
Score = 98.6 bits (244), Expect = 8e-21
Identities = 72/259 (27%), Positives = 127/259 (48%), Gaps = 10/259 (3%)
Query: 2 SEYSFAGKIALVTGASTGVGEGIARALFVRGATV-VITSRHLSEVQETAGNIDPSGSRVI 60
S +S GK L+TG S G+G IA+A G+ V ++ R+ ++ A D G +
Sbjct: 3 SMFSLKGKTTLITGGSGGIGFSIAKAFAAAGSNVGLLYGRNKKALEYAAELRDKHGVQAK 62
Query: 61 GKEVDVTVAKAVEDLIQEIREEFGA-LHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNI 119
+ AV + + EE G L ++ NAGI PH + +ED + D W +V+ N+
Sbjct: 63 AYSCPIENRSAVIETTNQAVEELGGRLDVMIANAGIAIPHLS-LEDKNEDIWTKVVGINL 121
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGI--PGISPYTATKHAVIGITQSV 177
NG +YT + A + +++ ++++G + + Y ATK AV + +++
Sbjct: 122 NGAYYTAQAA----GHHFKKQGKGSLIFTASMSGHIANWPQQWASYHATKAAVKHLARAL 177
Query: 178 ALEYAERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSP 237
A+E+A RVN+V+PGY+ T + ++ P R+ E+ L+L S
Sbjct: 178 AVEWAPF-ARVNSVSPGYIDTDLTLYADENLRKKWKEYTPQARIGLPDELPGAYLYLASD 236
Query: 238 LTGFTTGSVYPIDGGFLAQ 256
+ + TGS +DGG+ ++
Sbjct: 237 ASSYCTGSDIIVDGGYCSR 255
>At3g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 259
Score = 98.2 bits (243), Expect = 1e-20
Identities = 75/257 (29%), Positives = 126/257 (48%), Gaps = 10/257 (3%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVI 60
MS GKI ++TG ++G+G AR GA VVI Q A +I +
Sbjct: 1 MSGQRLDGKIVIITGGASGIGAEAARLFTDHGAKVVIVDLQEELGQNVAVSIGLDKASFY 60
Query: 61 GKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNIN 120
D+T VE+ ++ E+ G L L +NAG+ PH + I D D++++ + + N+
Sbjct: 61 --RCDITDETEVENAVKFTVEKHGKLDVLFSNAGVMEPHGS-ILDLDLEAFDRTMAVNVR 117
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
G +K+A M +S + S +V ++V +G PG YTA+KHA++G+ +S
Sbjct: 118 GAAAFIKHAARSMVASGTRGS---IVCTTSVTAEIGGPGPHSYTASKHALLGLVRSACGG 174
Query: 181 YAERNVRVNAVAPGYVSTPKI---QALPKETQQWMSSQHPMKRMATMT-EVSNTVLFLLS 236
+ +RVN VAP V+T + K + + S+ +K + V++ LFL S
Sbjct: 175 LGKYGIRVNGVAPYGVATGLTSYNEETVKMVEDYCSATAILKGVVLKARHVADAALFLAS 234
Query: 237 PLTGFTTGSVYPIDGGF 253
+ + +G +DGG+
Sbjct: 235 DDSVYISGQNLGVDGGY 251
>SPCC1739.08c [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 97.1 bits (240), Expect = 2e-20
Identities = 75/253 (29%), Positives = 131/253 (51%), Gaps = 14/253 (5%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
+S GK +V GA+ G+G IA A G V+IT ++ + +G +V +
Sbjct: 17 FSLKGKNCVVFGAAKGIGFSIATAFAQAGGNVIITYLTTDPTEKAKKLAEETGVQVHTLK 76
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
+D++ + VE ++EI++ F +H +V NAG+ P + + D + +V++ N N +
Sbjct: 77 IDISRSDTVEAGVEEIQKIFKEIHVVVANAGM--PFRRSVLDSPPHEFEKVMNINTN-SV 133
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIP-GISPYTATKHAVIGITQSVALEYA 182
Y + Y + + + A ++SA +V P I+ Y A+K AV + +++A+E+A
Sbjct: 134 YRVAYYMGKIFKKQGFGNLIATASMSAT--IVNAPQHIAAYCASKAAVRQLCKALAVEWA 191
Query: 183 ERNVRVNAVAPGYVST--PKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
E R+N+V+PGY +T P + L +QW P KR+ E+ T L+L S +
Sbjct: 192 E-FARINSVSPGYFATDMPGYEFL----KQW-EPYVPFKRLGLTPELRGTYLYLASNASS 245
Query: 241 FTTGSVYPIDGGF 253
F TG +DGG+
Sbjct: 246 FVTGLDLIVDGGY 258
>At3g26760 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 97.1 bits (240), Expect = 2e-20
Identities = 69/261 (26%), Positives = 127/261 (48%), Gaps = 24/261 (9%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPS--GSRVIGKEVD 65
GK+A++TG ++G+G+ A +GA V+I ++ E AG++ + GS D
Sbjct: 7 GKVAVITGGASGIGKATAEEFVSQGAQVIIV-----DIDEEAGHMVATELGSAAHFLRCD 61
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGIT-GPHQTGIEDYDIDSWRQVIDTNINGTFY 124
VT + + ++ G L ++N+AGI+ I D D+D++ +V+ N+ GT
Sbjct: 62 VTEEEQIAKAVETAVTRHGKLDVMLNSAGISCSISPPSIADLDMDTYDKVMRLNVRGTVL 121
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER 184
+K+A M P +++ LS+++GL+G G Y+ +K + G+ ++VA E +
Sbjct: 122 GIKHAARAM----IPAGSGSILCLSSISGLMGGLGPHAYSISKFTIPGVVKTVASELCKH 177
Query: 185 NVRVNAVAPGYVSTPKIQALPKETQQWMS-SQHPMKRMATMT-----------EVSNTVL 232
+R+N ++P + TP + +E S + + + T +V+ L
Sbjct: 178 GLRINCISPAGIPTPLTLRMFREAFAGHSIREEQLLAIVNATGELKGEKCEEIDVAKAAL 237
Query: 233 FLLSPLTGFTTGSVYPIDGGF 253
+L S F TG +DGGF
Sbjct: 238 YLASDDAKFVTGHNLVVDGGF 258
>Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 261
Score = 96.7 bits (239), Expect = 3e-20
Identities = 69/260 (26%), Positives = 127/260 (48%), Gaps = 14/260 (5%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV 64
S G +A++TG ++G+G A L +GA+ V+ S + A + G+ +
Sbjct: 7 SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPA 63
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGI----EDYDIDSWRQVIDTNIN 120
DVT K V+ + + +FG + VN AGI +T + + ++ +++V+D N+
Sbjct: 64 DVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLM 123
Query: 121 GTFYTLKYALPLMESSSSPDS---EAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV 177
GTF ++ M + PD ++N ++V G G + Y+A+K ++G+T +
Sbjct: 124 GTFNVIRLVAGEM-GQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
Query: 178 ALEYAERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPM-KRMATMTEVSNTVLFLLS 236
A + A +RV +APG TP + +LP++ +++SQ P R+ E ++ V ++
Sbjct: 183 ARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIE 242
Query: 237 PLTGFTTGSVYPIDGGFLAQ 256
F G V +DG Q
Sbjct: 243 --NPFLNGEVIRLDGAIRMQ 260
>Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 266
Score = 96.3 bits (238), Expect = 4e-20
Identities = 65/210 (30%), Positives = 108/210 (50%), Gaps = 27/210 (12%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHL-SEVQETAG---NIDPSGSRVIGKE 63
GK+ALVTGA+ G+G A AL ++GA V + +L + VQ A +P + I +
Sbjct: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKTLFI--Q 62
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTN----I 119
DV + + D +++ + FG L LVNNAG+ +W + + N I
Sbjct: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNE----------KNWEKTLQINLVSVI 112
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVAL 179
+GT+ L Y S + ++N+S++ GL+ + Y A+KH ++G T+S AL
Sbjct: 113 SGTYLGLDYM-----SKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAL 167
Query: 180 --EYAERNVRVNAVAPGYVSTPKIQALPKE 207
VR+NA+ PG+V+T ++++ KE
Sbjct: 168 AANLMNSGVRLNAICPGFVNTAILESIEKE 197
>CE02370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 309
Score = 96.3 bits (238), Expect = 4e-20
Identities = 74/255 (29%), Positives = 124/255 (48%), Gaps = 12/255 (4%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDP-SGSRVIGKE 63
+F GK+ LVTG TG+G+ IA ATVVI +R + ++++TA +I +G +
Sbjct: 22 AFKGKLVLVTGGGTGIGKAIATTFAHLRATVVIAARRMEKLEQTARDITKITGGTCEPFQ 81
Query: 64 VDVTVAKAVEDLIQEIREEFGAL-HYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
+D+ V D +I +FG + LVNNA G E +++ +ID + GT
Sbjct: 82 MDIKDPGMVSDAFDKIDMKFGKVPEILVNNA--AGNFIMATELLSSNAYGTIIDIVLKGT 139
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
F L + + A++ +++A G P I P +K V +T+S+A E++
Sbjct: 140 F---NVTTELGKRCIQNKTGASITSITAGYARAGAPFIVPSAVSKAGVETMTKSLATEWS 196
Query: 183 ERNVRVNAVAPGYVSTPKI-----QALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSP 237
+ +R NAV+PG + T + + M +P R+ + EV+N V F+ S
Sbjct: 197 KYGLRFNAVSPGPIPTKGAWGRLNSGEMGDIAEKMKFLNPEGRVGSPEEVANLVAFISSD 256
Query: 238 LTGFTTGSVYPIDGG 252
F G++ +DGG
Sbjct: 257 HMSFLNGAIIDLDGG 271
>At3g51680 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 95.9 bits (237), Expect = 5e-20
Identities = 71/268 (26%), Positives = 126/268 (46%), Gaps = 31/268 (11%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-------DPSGSRVI 60
GK+A++TG + G+G+ GATVVI ++V AG+ + V
Sbjct: 34 GKVAIITGGAHGIGKATVMLFARHGATVVI-----ADVDNVAGSSLAKSLSSHKTSPMVA 88
Query: 61 GKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQT--GIEDYDIDSWRQVIDTN 118
DV+V VE+L+ +G L L NNAG+ G + I D+D D + V+ N
Sbjct: 89 FISCDVSVEADVENLVNVTVARYGRLDILFNNAGVLGDQKKHKSILDFDADEFDHVMRVN 148
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA 178
+ G +K+ M + +++ ++V G++G G YTA+KHA++G+T++ A
Sbjct: 149 VRGVGLGMKHGARAMIKRGF---KGCIISTASVAGVMGGMGPHAYTASKHAIVGLTKNAA 205
Query: 179 LEYAERNVRVNAVAP-GYVSTPKIQALPK------------ETQQWMSSQHPMK-RMATM 224
E + +RVN ++P G ++ + A K E ++++ S +K
Sbjct: 206 CELGKYGIRVNCISPFGVATSMLVNAWRKTSGGDVEDDDVEEMEEFVRSLANLKGETLRA 265
Query: 225 TEVSNTVLFLLSPLTGFTTGSVYPIDGG 252
+++ L+L S + + G +DGG
Sbjct: 266 NDIAEAALYLASDESKYVNGHNLVVDGG 293
>At4g03140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 283
Score = 95.1 bits (235), Expect = 8e-20
Identities = 66/256 (25%), Positives = 119/256 (45%), Gaps = 17/256 (6%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
GK+AL+TG ++G+G+ A GA V+I +ET + PS + DVT
Sbjct: 20 GKVALITGGASGIGKATAGKFISHGAKVIIADIQPQIGRETEQELGPSCAYF---PCDVT 76
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
+ + + L + NNAGI I D D++ + +VI+TN+ G +K
Sbjct: 77 KESDIANAVDFAVSLHTKLDIMYNNAGIPCKTPPSIVDLDLNVFDKVINTNVRGVMAGIK 136
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVR 187
+A +M P + +++ +V G++G Y+ +K AVIGI +S A E + +R
Sbjct: 137 HAARVM----IPRNSGSIICAGSVTGMMGGLAQHTYSVSKSAVIGIVRSTASELCKHRIR 192
Query: 188 VNAVAPGYVSTPKIQALPKETQQWMSSQHPMK----------RMATMTEVSNTVLFLLSP 237
VN ++P ++T + ++ + ++ + T+V+N ++L S
Sbjct: 193 VNCISPFAITTSFVMDEMRQIYPGVDDSRLIQIVQSTGVLNGEVCEPTDVANAAVYLASD 252
Query: 238 LTGFTTGSVYPIDGGF 253
+ + G +DGGF
Sbjct: 253 DSKYVNGHNLVVDGGF 268
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 94.7 bits (234), Expect = 1e-19
Identities = 76/263 (28%), Positives = 122/263 (45%), Gaps = 21/263 (7%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+GK+ALVTG+S G+G A L GA V IT R+ ++ET I SG V+
Sbjct: 4 FSGKVALVTGSSNGIGRATAVLLAQEGAKVTITGRNADRLEETRQEILKSGVPEDHVLSI 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGI--EDYDIDSWRQVIDTNIN 120
D+ K ++L+ ++FG L LVNNAG G D D+ + +++ N+
Sbjct: 64 ATDLATEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDRIMQINMR 123
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVN-GLVGIPGISPYTATKHAVIGITQSVAL 179
L ++ VVN+S++ G P Y +K A+ T+S A+
Sbjct: 124 SV-----VTLTQKAKEHLVKAKGEVVNVSSIGAGPQAQPTFMYYAMSKAALDQYTRSAAI 178
Query: 180 EYAERNVRVNAVAPGYVST--PKIQALPKETQQ----WMSSQH---PMKRMATMTEVSNT 230
+ + VRVN+V+PG V T + +P + + +M S+ P +M +++N
Sbjct: 179 DLIQYGVRVNSVSPGAVVTGFGEAMGMPADMHEKYGHFMESRKECIPCGKMGQPIDIANI 238
Query: 231 VLFLLS-PLTGFTTGSVYPIDGG 252
+ FL L+ + G DGG
Sbjct: 239 IAFLADRKLSSYIIGQSIVADGG 261
>CE27260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 206
Score = 93.6 bits (231), Expect = 2e-19
Identities = 64/195 (32%), Positives = 107/195 (54%), Gaps = 16/195 (8%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSR---VIGKEVDV 66
+A+VTGAS+G+G A L + +T R+++ + E AG I +GS V+ V++
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVEL 62
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGI--TGPH-QTGIEDYDIDSWRQVIDTNINGTF 123
+A + ++ ++FG + L+N+AGI GP +GIE YD ++++ N+
Sbjct: 63 ASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYD-----ELMNVNVRSLI 117
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
+ ALP + ++ + VVN+S++NG G++ Y +K AV T+ +ALE A
Sbjct: 118 RLTRAALPHIITT-----KGTVVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEMAP 172
Query: 184 RNVRVNAVAPGYVST 198
VRVNAV PG + T
Sbjct: 173 NGVRVNAVCPGVIVT 187
>At2g47130 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 93.6 bits (231), Expect = 2e-19
Identities = 79/266 (29%), Positives = 132/266 (48%), Gaps = 28/266 (10%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAG-NIDPSGSRV 59
MS GKIA++TG ++G+G R GA VVI + QE G N+ S
Sbjct: 1 MSGLRLDGKIAIITGGASGIGAEAVRLFTDHGAKVVIV-----DFQEELGQNVAVS---- 51
Query: 60 IGKE------VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTG-IEDYDIDSWR 112
+GK+ DVT K VE+ ++ E++G L L +NAG+ Q G D +++ +
Sbjct: 52 VGKDKASFYRCDVTNEKEVENAVKFTVEKYGKLDVLFSNAGVM--EQPGSFLDLNLEQFD 109
Query: 113 QVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIG 172
+ + N+ G +K+A M + S +V ++V +G PG YTA+KHA++G
Sbjct: 110 RTMAVNVRGAAAFIKHAARAMVEKGTRGS---IVCTTSVASEIGGPGPHAYTASKHALLG 166
Query: 173 ITQSVALEYAERNVRVNAVAPGYVSTPKIQALPKET----QQWMSSQHPMKRMATMT-EV 227
+ +S + +RVN VAP V+T I + +ET +++ ++ +K + V
Sbjct: 167 LVKSACGGLGKYGIRVNGVAPYAVAT-AINSRDEETVRMVEEYSAATGILKGVVLKARHV 225
Query: 228 SNTVLFLLSPLTGFTTGSVYPIDGGF 253
+ LFL S + + +G +DGG+
Sbjct: 226 AEAALFLASDDSAYVSGQNLAVDGGY 251
>CE27259 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 501
Score = 93.2 bits (230), Expect = 3e-19
Identities = 64/195 (32%), Positives = 106/195 (53%), Gaps = 16/195 (8%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSR---VIGKEVDV 66
+A+VTGAS+G+G A L + +T R+++ + E AG I +GS V+ V++
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVEL 62
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGI--TGPH-QTGIEDYDIDSWRQVIDTNINGTF 123
+A + ++ ++FG + L+N+AGI GP +GIE YD ++++ N+
Sbjct: 63 ASEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYD-----ELMNVNVRSLI 117
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
+ ALP + ++ + VVN+S++NG P ++ Y +K AV T+ +ALE A
Sbjct: 118 RLTRAALPHIITT-----KGTVVNVSSINGPCPFPNVTYYCMSKSAVDQFTKCLALEMAP 172
Query: 184 RNVRVNAVAPGYVST 198
VRVNAV PG T
Sbjct: 173 NGVRVNAVCPGVTVT 187
Score = 58.5 bits (140), Expect = 9e-09
Identities = 40/114 (35%), Positives = 63/114 (55%), Gaps = 13/114 (11%)
Query: 88 YLVNNAGI--TGPH-QTGIEDYDIDSWRQVIDTNINGTFYTLKYALPLMESSSSPDSEAA 144
+ +N+AGI GP +GIE YD ++++ N+ + ALP + ++ +
Sbjct: 379 FQINSAGILRAGPVLDSGIEVYD-----ELMNVNVRSLIRLTRAALPHIITT-----KGT 428
Query: 145 VVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRVNAVAPGYVST 198
VVN+S++NG G++ Y +K AV T+ +ALE A VRVNAV PG + T
Sbjct: 429 VVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVCPGVIVT 482
>CE06649 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 92.8 bits (229), Expect = 4e-19
Identities = 73/265 (27%), Positives = 132/265 (49%), Gaps = 23/265 (8%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSR---VIGK 62
F+GK+ L++G+S G+G+ A GA +V+ R +V++T G++ ++
Sbjct: 6 FSGKVVLISGSSKGIGQATAVKFAAEGAKIVLNGRSADDVEKTRKLCMEVGAKPWDLLPT 65
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
D+T V+ ++ + FG L L+NNAG TG E +++ V+D + N
Sbjct: 66 VGDITNEDFVKMMVNTVIHNFGKLDILINNAGTLEVDMTGKEGWEMGV--DVMDRSWNSN 123
Query: 123 FYTLKYALPLMESSSSP--DSEAAVVNLSAV--NGLVGIPGISPYTATKHAVIGITQSVA 178
F K L L +++ ++ +VN+S +G +G+ + Y K A+ +++S+A
Sbjct: 124 F---KSVLMLTQAAMPHLIKTKGDIVNVSTFLSSGPIGVMSMPYYAVPKAALDQMSRSMA 180
Query: 179 LEYAERNVRVNAVAPGYVSTPKIQALP-------KETQQWMSSQH---PMKRMATMTEVS 228
EY + VR+N V PG VST LP ++ + ++ S+ P+ R+ ++V+
Sbjct: 181 HEYMLKGVRLNTVNPGLVSTSFFARLPGVGDDNARKMENYVQSKTEYIPLGRVCQASDVA 240
Query: 229 NTVLFLLS-PLTGFTTGSVYPIDGG 252
T+LFL ++ G IDGG
Sbjct: 241 ETILFLADRKVSECIVGQSIIIDGG 265
>At5g50700 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 92.4 bits (228), Expect = 5e-19
Identities = 63/197 (31%), Positives = 103/197 (51%), Gaps = 10/197 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS-RVIGKEVDV 66
GK+ L+TGAS+G+GE +A RGA + +T+R + ++E A GS V+ DV
Sbjct: 47 GKVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADV 106
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQ-TGIEDYDIDSWRQVIDTNINGTFYT 125
+ ++ + FG L +LVNNAG+T IE DI + V+DTN G+ YT
Sbjct: 107 SKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIE--DITRTKAVLDTNFWGSVYT 164
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+ ALP + S+ +V +S+ + P +S Y A+K A++ +++ +E +
Sbjct: 165 TRAALPYLRQSN-----GKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELG-GD 218
Query: 186 VRVNAVAPGYVSTPKIQ 202
V + V PGY+ + Q
Sbjct: 219 VHITIVTPGYIESELTQ 235
>At5g50600 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 92.4 bits (228), Expect = 5e-19
Identities = 63/197 (31%), Positives = 103/197 (51%), Gaps = 10/197 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS-RVIGKEVDV 66
GK+ L+TGAS+G+GE +A RGA + +T+R + ++E A GS V+ DV
Sbjct: 47 GKVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADV 106
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQ-TGIEDYDIDSWRQVIDTNINGTFYT 125
+ ++ + FG L +LVNNAG+T IE DI + V+DTN G+ YT
Sbjct: 107 SKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIE--DITRTKAVLDTNFWGSVYT 164
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+ ALP + S+ +V +S+ + P +S Y A+K A++ +++ +E +
Sbjct: 165 TRAALPYLRQSN-----GKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELG-GD 218
Query: 186 VRVNAVAPGYVSTPKIQ 202
V + V PGY+ + Q
Sbjct: 219 VHITIVTPGYIESELTQ 235
>CE02315 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 309
Score = 92.0 bits (227), Expect = 7e-19
Identities = 74/252 (29%), Positives = 118/252 (46%), Gaps = 12/252 (4%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-DPSGSRVIGKEVDV 66
GK+ALVTG TG+G+ IA GA+V I +R + ++++TA I +G +D+
Sbjct: 25 GKVALVTGGGTGIGKAIATTFAHLGASVAIAARRMEKLEQTAEEIMKTTGGICEPFRMDI 84
Query: 67 TVAKAVEDLIQEIREEFGA-LHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
V D +I ++FG LVNNA G E ++ +ID + G T
Sbjct: 85 KDPGMVSDTFDKIDKKFGKHPDILVNNA--AGNFIMATERLSPNAHGTIIDIVLKG---T 139
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+ L + + A+V +++A G P I P +K V +T+S+A E+++
Sbjct: 140 MNVTTELGKRCIQSKTGASVTSITAAYARSGAPFIVPSAVSKAGVEIMTKSLATEWSKYG 199
Query: 186 VRVNAVAPGYVSTP-----KIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
+R NAV+PG + T + + M +P R T EV+N V F+ S
Sbjct: 200 LRFNAVSPGPIPTKGAWGRLFSGEMGDVAEKMKELNPEGRSGTPEEVANLVAFISSDHMS 259
Query: 241 FTTGSVYPIDGG 252
F G + +DGG
Sbjct: 260 FMNGVIIDLDGG 271
>At4g05530 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 254
Score = 92.0 bits (227), Expect = 7e-19
Identities = 67/250 (26%), Positives = 123/250 (48%), Gaps = 16/250 (6%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
GK+A+VT ++ G+G GI + GA+VV++SR + V E + G G V+
Sbjct: 11 GKVAIVTASTQGIGFGITERFGLEGASVVVSSRKQANVDEAVAKLKSKGIDAYGIVCHVS 70
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGI---TGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
A+ +L+++ +++G + +V NA T P + E W + N+ +
Sbjct: 71 NAQHRRNLVEKTVQKYGKIDIVVCNAAANPSTDPILSSKEAVLDKLW----EINVKSSIL 126
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER 184
L+ P +E SS V+ ++++ G ++ Y TK A++G+T+++A E A
Sbjct: 127 LLQDMAPHLEKGSS------VIFITSIAGFSPQGAMAMYGVTKTALLGLTKALAAEMAP- 179
Query: 185 NVRVNAVAPGYVSTPKIQAL--PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFT 242
+ RVNAVAPG+V T + E ++ + + + R+ T +++ FL S + +
Sbjct: 180 DTRVNAVAPGFVPTHFASFITGSSEVREGIEEKTLLNRLGTTGDMAAAAAFLASDDSSYI 239
Query: 243 TGSVYPIDGG 252
TG + GG
Sbjct: 240 TGETLVVAGG 249
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 91.7 bits (226), Expect = 9e-19
Identities = 59/199 (29%), Positives = 101/199 (50%), Gaps = 11/199 (5%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F K+A++TG+S G+G+ AR L GA V +T R+ ++ET + +G V+
Sbjct: 4 FTDKVAIITGSSNGIGQATARLLASEGAKVTVTGRNAERLEETKNILLGAGVPEGNVLVV 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIE--DYDIDSWRQVIDTNIN 120
D+T E+LI+ ++FG + LVNNAG P G + ID++ + + N+
Sbjct: 64 VGDITQESVQENLIKSTLDKFGKIDILVNNAGAGIPDAQGKSGVNQSIDTYHKTFELNVQ 123
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP-YTATKHAVIGITQSVAL 179
+ A P + ++ +VN+S++ SP Y+ K A+ T++ A+
Sbjct: 124 SVIEMTQKARPHLAK-----TQGEIVNISSIGAGPAAQVASPYYSIAKAALDQYTRTAAI 178
Query: 180 EYAERNVRVNAVAPGYVST 198
+ +RVN+V+PG VST
Sbjct: 179 DLVPEGIRVNSVSPGAVST 197
>Hs7705925 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 244
Score = 91.3 bits (225), Expect = 1e-18
Identities = 78/258 (30%), Positives = 120/258 (46%), Gaps = 21/258 (8%)
Query: 3 EYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGK 62
E AG+ LVTGA G+G G +AL GA VV SR T ++D G
Sbjct: 2 ELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSR-------TQADLDSLVRECPGI 54
Query: 63 E---VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNI 119
E VD+ +A E + + G + LVNNA + + +++ + + N+
Sbjct: 55 EPVCVDLGDWEATERALGSV----GPVDLLVNNAAVALLQP--FLEVTKEAFDRSFEVNL 108
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVAL 179
+ + + P A+VN+S+ + S Y +TK A+ +T+ +AL
Sbjct: 109 RAVIQVSQIVARGLIARGVP---GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMAL 165
Query: 180 EYAERNVRVNAVAPGYVSTPKIQALPKETQQ--WMSSQHPMKRMATMTEVSNTVLFLLSP 237
E +RVNAV P V T QA + + M ++ P+ + A + V N +LFLLS
Sbjct: 166 ELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSD 225
Query: 238 LTGFTTGSVYPIDGGFLA 255
+G TTGS P++GGF A
Sbjct: 226 RSGMTTGSTLPVEGGFWA 243
>At5g18210 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 91.3 bits (225), Expect = 1e-18
Identities = 71/258 (27%), Positives = 120/258 (45%), Gaps = 12/258 (4%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVIT-SRHLSEVQETAGNIDPSGSRV---- 59
S AG++A+VTG+S G+G IA L GA +VI + +E + A I+ S V
Sbjct: 7 SLAGRVAIVTGSSRGIGRAIAIHLAELGAKIVINYTTRSTEADQVAAEINSSAGTVPQPI 66
Query: 60 -IGKEVDVTVAKAVEDLIQEIREEFGA-LHYLVNNAGITGPHQTGIEDYDIDSWRQVIDT 117
+ D++ ++ L + F + +H LVN+AGI P+ I + I+ + ++
Sbjct: 67 AVVFLADISEPSQIKSLFDAAEKAFNSPVHILVNSAGILNPNYPTIANTPIEEFDRIFKV 126
Query: 118 NINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV 177
N G+F K A ++ ++ L++ IPG YTA+K AV + + +
Sbjct: 127 NTRGSFLCCKEAAKRLKRGGG----GRIILLTSSLTEALIPGQGAYTASKAAVEAMVKIL 182
Query: 178 ALEYAERNVRVNAVAPGYVSTPK-IQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLS 236
A E + N V+PG V+T +ET + + P R+ ++++ V FL S
Sbjct: 183 AKELKGLGITANCVSPGPVATEMFFDGKSEETVMNIIERSPFGRLGETKDIASVVGFLAS 242
Query: 237 PLTGFTTGSVYPIDGGFL 254
+ G V +G FL
Sbjct: 243 DGGEWINGQVIVANGAFL 260
>At3g29250 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 90.9 bits (224), Expect = 2e-18
Identities = 71/261 (27%), Positives = 125/261 (47%), Gaps = 17/261 (6%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGN---IDPSGS 57
MS GKIA++TG ++G+G R GA VVI ++QE G +
Sbjct: 1 MSGLRLDGKIAIITGGASGIGAEAVRLFTDHGAKVVIV-----DIQEELGQNLAVSIGLD 55
Query: 58 RVIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDT 117
+ +VT VE+ ++ E+ G L L +NAG+ + + D D++++ + +
Sbjct: 56 KASFYRCNVTDETDVENAVKFTVEKHGKLDVLFSNAGVLEAFGS-VLDLDLEAFDRTMAV 114
Query: 118 NINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV 177
N+ G +K+A M +S + S +++A +G PG YTA+KHA++G+ +S
Sbjct: 115 NVRGAAAFIKHAARSMVASGTRGSIVCTTSIAAE---IGGPGPHSYTASKHALLGLIRSA 171
Query: 178 ALEYAERNVRVNAVAPGYVSTPKIQALPKET----QQWMSSQHPMKRMATMT-EVSNTVL 232
+ +RVN VAP V+T A +E +++ + +K + ++ L
Sbjct: 172 CAGLGQYGIRVNGVAPYGVATGMTSAYNEEAVKMLEEYGEALGNLKGVVLKARHIAEAAL 231
Query: 233 FLLSPLTGFTTGSVYPIDGGF 253
FL S + + +G +DGGF
Sbjct: 232 FLASDDSVYISGQNLVVDGGF 252
>7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 242
Score = 90.9 bits (224), Expect = 2e-18
Identities = 75/257 (29%), Positives = 128/257 (49%), Gaps = 33/257 (12%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
AGK+ LVTGA G+G+ + + L GATV+ +R ++Q+ DP + + ++D+
Sbjct: 6 AGKVILVTGAGAGIGQALVKQLASAGATVIAVARKPEQLQQLVA-FDPVHIQPL--QLDL 62
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGIT--GPHQTGIEDYDIDSWRQVIDTNINGTFY 124
+ +AV + + ++ L LVNNAG+ P + + + D D+ D NI F
Sbjct: 63 SGWQAVREGLAKVP----LLDGLVNNAGVAIIKPFEE-LTEQDFDTH---FDVNIKAVFN 114
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER 184
+ LP ++ +S +VN+S++ G + Y+ATK A+ +T+S+ALE R
Sbjct: 115 VTQSLLPRLKDGAS------IVNVSSIASSRSFGGHTAYSATKAALDSLTKSLALELGPR 168
Query: 185 NVRVNAVAPGYVSTPKIQALPKETQQW--------MSSQHPMKRMATMTEVSNTVLFLLS 236
+RVN+V P V T K+ A W + + P+ R + EV + +LLS
Sbjct: 169 KIRVNSVNPTVVLT-KMGA-----DNWSDPAKSGPLLAHIPLNRFCEVQEVVDATGYLLS 222
Query: 237 PLTGFTTGSVYPIDGGF 253
+ F G ++GG+
Sbjct: 223 SKSSFVNGHHILLEGGY 239
>CE10908 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 313
Score = 90.5 bits (223), Expect = 2e-18
Identities = 71/255 (27%), Positives = 117/255 (45%), Gaps = 12/255 (4%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGK-E 63
S GK+ALVTG TG+G+ IA GA+V I +R L +++TA I S V +
Sbjct: 23 SLNGKVALVTGGGTGLGKAIATTFAHLGASVAIAARRLDVLEKTADEIRSSTGGVCEPFQ 82
Query: 64 VDVTVAKAVEDLIQEIREEFG-ALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
+DV V + ++ G L+NNA G E +++ +ID + G
Sbjct: 83 MDVKDPAKVAKAFDAVEKKLGHTPDILINNA--AGNFIMATERLSPNAYGTIIDIVLKG- 139
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
TL L A+V++++ + G P + P +K V +T+S+A E+A
Sbjct: 140 --TLHVTTELGRRCIQQKRGASVLSITTLYAQSGAPFVVPSAVSKAGVENMTKSLASEWA 197
Query: 183 ERNVRVNAVAPGYVSTP-----KIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSP 237
+ +R NA+APG + T K++ M + P+ R+ E++N F+ S
Sbjct: 198 KHGLRFNAIAPGPIPTEGAFGRLFAGELKDSGDAMKASVPVGRLGHPEEIANLAAFMSSD 257
Query: 238 LTGFTTGSVYPIDGG 252
+ G++ DGG
Sbjct: 258 FMSWMNGAIIDFDGG 272
>At4g13180 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 263
Score = 90.5 bits (223), Expect = 2e-18
Identities = 72/258 (27%), Positives = 117/258 (44%), Gaps = 9/258 (3%)
Query: 2 SEYSFAGKIALVTGASTGVGEGIARALFVRGATVVI---TSRHLSEVQETAGNIDPSGSR 58
S AG++A+VTGA+ G+G IA L GA V I +S +E+ + N
Sbjct: 9 SSLPLAGRVAIVTGATRGMGREIAIHLHSLGARVTINYVSSSSKAELLVSELNDSSQLKS 68
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEFGA-LHYLVNNAGITGPHQTGIEDYDIDSWRQVIDT 117
I + DV+ + +L + +EFG+ +H +VN AG+ P + + ++ +
Sbjct: 69 AIAVKADVSDPDQINNLFDQTEQEFGSKVHIVVNCAGVLDPKYPSLSETTLEDFDNTFTI 128
Query: 118 NINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV 177
N G+F K A + +++ S V GL PG Y A+K AV + + +
Sbjct: 129 NTRGSFLCCKEAAKRVMRGGG--GRIIMMSTSMVGGLA--PGYGVYAASKAAVETMVKVL 184
Query: 178 ALEYAERNVRVNAVAPGYVSTPKIQA-LPKETQQWMSSQHPMKRMATMTEVSNTVLFLLS 236
A E + N VAPG V+T A ET + ++ PM R+ +++ V FL
Sbjct: 185 AKELKGSRITANCVAPGPVATEMFYAGKSDETVKMLAGACPMGRIGESKDITEIVGFLAG 244
Query: 237 PLTGFTTGSVYPIDGGFL 254
+ G V +GGF+
Sbjct: 245 DGGEWINGQVIRANGGFV 262
>CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 89.4 bits (220), Expect = 5e-18
Identities = 59/204 (28%), Positives = 96/204 (46%), Gaps = 9/204 (4%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K L+TGA G+G+ +A+ RGAT+++ +L V E I + EV++
Sbjct: 41 KKVLITGAGNGLGKLLAQKFAARGATLILWDINLQSVDELKNEIRGNQGEAHSYEVNLCD 100
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
+ + Q++ + G + LVNNAGI I D + + D N+ FYT++
Sbjct: 101 PGKIAQVGQQVINDIGKVDILVNNAGIATAKM--ILDSSENEINRSFDVNVKAHFYTVQQ 158
Query: 129 ALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE---RN 185
LP M D+ +V +++ G +G G++ Y++TKHA +G S+ E E
Sbjct: 159 FLPAM----LKDNNGHIVTIASAAGKMGSSGLADYSSTKHAAVGFHDSLVAEIMESEKNG 214
Query: 186 VRVNAVAPGYVSTPKIQALPKETQ 209
V+ V P YV T A T+
Sbjct: 215 VKTTLVCPYYVHTSMFDATGAATR 238
>CE21095 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 89.4 bits (220), Expect = 5e-18
Identities = 76/263 (28%), Positives = 117/263 (43%), Gaps = 21/263 (7%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+ K ++TG+S G+G A GA V IT R ++ET I SG +V
Sbjct: 4 FSNKTVIITGSSNGIGRTTAILFAQEGANVTITGRSSERLEETRQIILKSGVSEKQVNSV 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGI--EDYDIDSWRQVIDTNIN 120
DVT + +I ++FG + LVNNAG P G D ID + + + N+
Sbjct: 64 VADVTTEDGQDQIINSTLKQFGKIDVLVNNAGAAIPDAFGTTGTDQGIDIYHKTLKLNLQ 123
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSA-VNGLVGIPGISPYTATKHAVIGITQSVAL 179
K P + + S+ +VN+S+ V G P Y K A+ T+S A+
Sbjct: 124 AVIEMTKKVKPHLVA-----SKGEIVNVSSIVAGPQAQPDFLYYAIAKAALDQYTRSTAI 178
Query: 180 EYAERNVRVNAVAPGYVST--PKIQALPKETQQ----WMSSQH---PMKRMATMTEVSNT 230
+ A+ +RVN+V+PG V T +P + Q +M+S P+ ++N
Sbjct: 179 DLAKFGIRVNSVSPGMVETGFTNAMGMPDQASQKFYNFMASHKECIPIGAAGKPEHIANI 238
Query: 231 VLFLLS-PLTGFTTGSVYPIDGG 252
+LFL L+ + G DGG
Sbjct: 239 ILFLADRNLSFYILGQSIVADGG 261
>At2g47140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 88.6 bits (218), Expect = 8e-18
Identities = 71/256 (27%), Positives = 119/256 (45%), Gaps = 21/256 (8%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGN---IDPSGSRVIGKEV 64
GKI ++TG ++G+G R GA VVI +VQ+ G + +
Sbjct: 15 GKIVIITGGASGIGAESVRLFTEHGARVVIV-----DVQDELGQNVAVSIGEDKASYYHC 69
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
DVT VE+ ++ E++G L L +NAG+ P I D +++ + I N+ GT
Sbjct: 70 DVTNETEVENAVKFTVEKYGKLDVLFSNAGVIEPF-VSILDLNLNELDRTIAINLRGTAA 128
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP--YTATKHAVIGITQSVALEYA 182
+K+A M S +++A I G +P YT +KH ++G+ +S +
Sbjct: 129 FIKHAARAMVEKGIRGSIVCTTSVAAE-----IAGTAPHGYTTSKHGLLGLIKSASGGLG 183
Query: 183 ERNVRVNAVAPGYVSTPKI----QALPKETQQWMSSQHPMKRMATMT-EVSNTVLFLLSP 237
+ +RVN VAP V+TP + + P +Q S+ +K + V+ LFL S
Sbjct: 184 KYGIRVNGVAPFGVATPLVCNGFKMEPNVVEQNTSASANLKGIVLKARHVAEAALFLASD 243
Query: 238 LTGFTTGSVYPIDGGF 253
+ + +G +DGG+
Sbjct: 244 ESAYVSGQNLAVDGGY 259
>At3g04000 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 272
Score = 87.8 bits (216), Expect = 1e-17
Identities = 78/261 (29%), Positives = 120/261 (45%), Gaps = 17/261 (6%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVIT-SRHLSEVQETAGNIDPSGSR---VIGK 62
AG++A+VTG+S G+G IA L GA VV+ S E ++ A I + S+ V GK
Sbjct: 15 AGRVAIVTGSSRGIGRAIAIHLAELGARVVVNYSTSPVEAEKVATAITTNCSKDAEVAGK 74
Query: 63 EVDVTVAKA-------VEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQV 114
V V KA V+ L E F +H LVN+A I P+ + I D ++ + ++
Sbjct: 75 SPRVIVVKADISEPSQVKSLFDEAERVFESPVHILVNSAAIADPNHSTISDMSVELFDRI 134
Query: 115 IDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGIT 174
I N G F + A ++ +++ S V L YTA+K AV +
Sbjct: 135 ISVNTRGAFICAREAANRLKRGGG--GRIILLSTSLVQTL--NTNYGSYTASKAAVEAMA 190
Query: 175 QSVALEYAERNVRVNAVAPGYVSTPKI-QALPKETQQWMSSQHPMKRMATMTEVSNTVLF 233
+ +A E + VN V+PG V+T L E + + SQ+ R+ +++ V F
Sbjct: 191 KILAKELKGTEITVNCVSPGPVATEMFYTGLSNEIVEKVKSQNLFGRIGETKDIAPVVGF 250
Query: 234 LLSPLTGFTTGSVYPIDGGFL 254
L S + G V +GG L
Sbjct: 251 LASDAGEWINGQVIMANGGCL 271
>7301818 [Q] KOG1205 Predicted dehydrogenase
Length = 326
Score = 87.8 bits (216), Expect = 1e-17
Identities = 54/196 (27%), Positives = 97/196 (48%), Gaps = 12/196 (6%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQET-----AGNIDPSGSRVIGK 62
GK+ L+TGAS+G+GE +A + G V++ +R E++ A ++DP+ +
Sbjct: 53 GKVVLITGASSGLGESLAHVFYRAGCRVILAARRTQELERVKKDLLALDVDPAYPPTV-L 111
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
+D+ ++ + + + + + L+NN GI+ D+D +V+ N G+
Sbjct: 112 PLDLAELNSIPEFVTRVLAVYNQVDILINNGGISVRADVASTAVDVDL--KVMVVNYFGS 169
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
K LP M S + +S+V G IP + Y+A+KHA+ S+ E A
Sbjct: 170 VALTKALLPSMVKRGS----GHICFISSVQGKFAIPQRAAYSASKHAMQAFADSLRAEVA 225
Query: 183 ERNVRVNAVAPGYVST 198
+N+ V+ V+PGY+ T
Sbjct: 226 NKNINVSCVSPGYIRT 241
>SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 236
Score = 87.4 bits (215), Expect = 2e-17
Identities = 67/244 (27%), Positives = 124/244 (50%), Gaps = 16/244 (6%)
Query: 12 LVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVAKA 71
L+TG S+G+G+ IA+ +G I R+ ++ET ++ S G++ +T+A
Sbjct: 5 LITGGSSGLGKRIAQIWSQKGHQCHIVGRNEFHLKETLQSL----SVAKGQQHTLTIADV 60
Query: 72 VEDLIQEIREEFGALHY--LVNNAGITGPHQ-TGIEDYDIDSWRQVIDTNINGTFYTLKY 128
D+ + ++ F ++ +V+ AG+ + +IDS +I TN+ K
Sbjct: 61 QSDM-KNLKSIFESVEIDTVVHAAGVLQSSLCVRTSEKEIDS---IICTNLVSAIKLSKM 116
Query: 129 ALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRV 188
A+ + + + + ++N+S+ +PG S Y A+K + T+ +A E A + +RV
Sbjct: 117 AILEWFRNKNSERDRLILNISSRLSTYALPGTSVYAASKAGLESFTKVLAAEVASKGIRV 176
Query: 189 NAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTGSVYP 248
NA++PGYV TP L + + + P+ R+A+ E+ + FLL +TTG++ P
Sbjct: 177 NAISPGYVDTP---MLSSQIRAIAEKKVPIGRLASTDEIVDACTFLLD--NRYTTGTILP 231
Query: 249 IDGG 252
I GG
Sbjct: 232 ITGG 235
>YNL202w [R] KOG0725 Reductases with broad range of substrate specificities
Length = 295
Score = 87.0 bits (214), Expect = 2e-17
Identities = 61/254 (24%), Positives = 125/254 (49%), Gaps = 15/254 (5%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-----DPSGSRVI 60
F GK+A VTG + + AL + G I R ++ A I D I
Sbjct: 25 FKGKVAFVTGGAGTICRVQTEALVLLGCKAAIVGRDQERTEQAAKGISQLAKDKDAVLAI 84
Query: 61 GKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNIN 120
VDV + VE+ +++ E+FG + +++ AG G + ++++ V+D ++
Sbjct: 85 AN-VDVRNFEQVENAVKKTVEKFGKIDFVI--AGAAGNFVCDFANLSPNAFKSVVDIDLL 141
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
G+F T K L ++ S + +++ +SA G+P A K + + +++A+E
Sbjct: 142 GSFNTAKACLKELKKS-----KGSILFVSATFHYYGVPFQGHVGAAKAGIDALAKNLAVE 196
Query: 181 YAERNVRVNAVAPGYV-STPKIQALP-KETQQWMSSQHPMKRMATMTEVSNTVLFLLSPL 238
+R N +APG + +T ++ L K+ ++ ++ P++R+ + +++ + +++ SP
Sbjct: 197 LGPLGIRSNCIAPGAIDNTEGLKRLAGKKYKEKALAKIPLQRLGSTRDIAESTVYIFSPA 256
Query: 239 TGFTTGSVYPIDGG 252
+ TG+V +DGG
Sbjct: 257 ASYVTGTVLVVDGG 270
>At3g03980 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 87.0 bits (214), Expect = 2e-17
Identities = 69/260 (26%), Positives = 113/260 (42%), Gaps = 16/260 (6%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVI--------TSRHLSEVQE--TAGNIDPSG 56
AG++A+VTG+S G+G IA L GA +VI R SE+ + I G
Sbjct: 15 AGRVAIVTGSSRGIGRAIAIHLAELGARIVINYTSKAADAERVASEINDFPVREEITGKG 74
Query: 57 SRVIGKEVDVTVAKAVEDLIQEIREEFGA-LHYLVNNAGITGPHQTGIEDYDIDSWRQVI 115
R I + +V+ V+ + F A +H LVN+AGI P I D ++ +
Sbjct: 75 PRAIVVQANVSEPSQVKSMFDAAESAFEAPVHILVNSAGILDPKYPTIADTSVEDFDHTF 134
Query: 116 DTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQ 175
N G F K A ++ ++ L++ PG Y A+K AV + +
Sbjct: 135 SVNTKGAFLCSKEAANRLKQGGG----GRIILLTSSQTRSLKPGFGAYAASKAAVETMVK 190
Query: 176 SVALEYAERNVRVNAVAPGYVSTPK-IQALPKETQQWMSSQHPMKRMATMTEVSNTVLFL 234
+A E + N VAPG ++T E + ++++ P R+ +V V FL
Sbjct: 191 ILAKELKGTGITANCVAPGPIATEMFFDGKTPELVEKIAAESPFGRVGEAKDVVPLVGFL 250
Query: 235 LSPLTGFTTGSVYPIDGGFL 254
+ G + P++GG++
Sbjct: 251 AGDGGEWVNGQIIPVNGGYV 270
>CE21092 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 86.3 bits (212), Expect = 4e-17
Identities = 73/271 (26%), Positives = 128/271 (46%), Gaps = 37/271 (13%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSR------V 59
F+ K+A++TG+S+G+G A L GA V +T R ++QET I +G V
Sbjct: 4 FSDKVAIITGSSSGIGRSTAVLLAQEGAKVTVTGRSSEKIQETVNEIHKNGGSSDNINIV 63
Query: 60 IGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGI--EDYDIDSWRQVIDT 117
+G D+ ++ ++LI+ FG + L+NNAG +G + I + ++
Sbjct: 64 LG---DLNESECQDELIKSTLSRFGKIDILINNAGAAFADPSGKIGSEAAIGIFDDMMKL 120
Query: 118 NINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYT------ATKHAVI 171
N+ +K P + + S+ +VN+S++ G PY K +
Sbjct: 121 NLRSVVELVKKCRPHLIA-----SKGEIVNVSSI-----AAGPQPYIYYTYYGICKAGLD 170
Query: 172 GITQSVALEYAERNVRVNAVAPGYVSTPKIQA------LPKETQQWMSSQH---PMKRMA 222
+T+S+ALE +VRVN+V+PG +ST + A + K+T+++ S+ P R
Sbjct: 171 QLTRSLALELIPFDVRVNSVSPGLISTNFLGAVGMGDDVVKKTEEYYSTHRDCIPAGRTG 230
Query: 223 TMTEVSNTVLFLLS-PLTGFTTGSVYPIDGG 252
E+++ + FL + + G IDGG
Sbjct: 231 KPEEIASLIAFLADRKSSAYIIGQSIVIDGG 261
>At5g50590 [Q] KOG1205 Predicted dehydrogenase
Length = 299
Score = 86.3 bits (212), Expect = 4e-17
Identities = 63/207 (30%), Positives = 102/207 (48%), Gaps = 11/207 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS-RVIGKEVDV 66
GK+ ++TG+S+G+GE +A RGA + + +R +Q A GS V DV
Sbjct: 47 GKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGDV 106
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDY-DIDSWRQVIDTNINGTFYT 125
+V K + +QE FG L +LVNNAGI EDY +I +++TN G Y
Sbjct: 107 SVIKDCKRFVQETISRFGRLDHLVNNAGIA--EAKFFEDYSEISDVLPIVNTNFWGPVYA 164
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+A+P ++ ++ ++ +++ G G+P +S Y A+K A+I +++ +E
Sbjct: 165 THFAIPHLKK-----TKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIE-LHPE 218
Query: 186 VRVNAVAPGYVSTPKIQA-LPKETQQW 211
V V V PG + L E Q W
Sbjct: 219 VGVTIVFPGLIENGNTNPDLLAEKQDW 245
>At1g10310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 242
Score = 86.3 bits (212), Expect = 4e-17
Identities = 60/196 (30%), Positives = 101/196 (50%), Gaps = 15/196 (7%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
A + L+TG S G+G +A L RG TV+ +R ++ + S + ++ DV
Sbjct: 16 AARTVLITGVSKGLGRALALELAKRGHTVIGCARSQEKLTALQSELSSSTNHLL-LTADV 74
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPH----QTGIEDYDIDSWRQVIDTNINGT 122
+VE++ I E+ G +VNNAG + + ED+D V+DTN+ G
Sbjct: 75 KSNSSVEEMAHTIVEKKGVPDIIVNNAGTINKNSKIWEVSAEDFD-----NVMDTNVKGV 129
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
L++ +PLM P + +VN+S+ G G ++PY A+K A+ G++++VA E
Sbjct: 130 ANVLRHFIPLM----LPRKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKEVV 185
Query: 183 ERNVRVNAVAPGYVST 198
E + V A+ PG ++T
Sbjct: 186 E-GMAVVALNPGVINT 200
>CE03132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 85.1 bits (209), Expect = 9e-17
Identities = 61/200 (30%), Positives = 100/200 (49%), Gaps = 13/200 (6%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+ K+A++TG+S+G+G A GA V +T R +++ET + +G S +
Sbjct: 5 FSKKVAIITGSSSGIGRETALLFAKEGAKVTVTGRSEEKLEETKKALLDAGIKESNFLIV 64
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGP---HQTGIEDYDIDSWRQVIDTNI 119
D+T + ++LI + ++FG ++ LVNNAG + P +TGI D I+++ QV+ N+
Sbjct: 65 PADITFSTGQDELISQTLKKFGRINILVNNAGASIPDAKKRTGI-DQGIETYEQVMKLNV 123
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGL-VGIPGISPYTATKHAVIGITQSVA 178
+ P + S +VN+S+V L G Y K A+ T+S A
Sbjct: 124 QSVIEMTQKVRPHLAK-----SRGEIVNVSSVVALKAGWTRTPYYPLAKAALDQYTRSAA 178
Query: 179 LEYAERNVRVNAVAPGYVST 198
+ +RVN V PG V T
Sbjct: 179 IALISEGIRVNTVNPGIVQT 198
>CE20725 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 84.7 bits (208), Expect = 1e-16
Identities = 76/265 (28%), Positives = 123/265 (45%), Gaps = 25/265 (9%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+GK+AL+TG+S G+G A +GA V IT R+ ++ET I SG ++
Sbjct: 4 FSGKVALITGSSNGIGRAAAILFAQQGAKVTITGRNAERLKETRHEIKKSGIPAENILAI 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAG---ITGPHQTGIEDYDIDSWRQVIDTNI 119
DV + LI + +FG L LVNNAG + + G+ D DI + + N+
Sbjct: 64 VADVITDEGQMRLINDTVRKFGHLDILVNNAGGALMDAQGRVGM-DQDISVFDNTMQINM 122
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAV-NGLVGIPGISPYTATKHAVIGITQSVA 178
++ A S+ ++N+SA+ G G P + Y +K A+ T+S A
Sbjct: 123 RSVVTLVQKA-----KEHLIKSKGEIINVSAMAAGHHGDPIATFYGMSKAALDQFTRSSA 177
Query: 179 LEYAERNVRVNAVAPGYVST--------PKIQALPKETQQWMSSQH--PMKRMATMTEVS 228
+ + VRVN+V+PG+ T P I A+ K + S + P +A +++
Sbjct: 178 ISLIQHGVRVNSVSPGFTKTGFGEAMGFPPI-AMKKVISFYESHKECAPSGAIAQPGDIA 236
Query: 229 NTVLFLLS-PLTGFTTGSVYPIDGG 252
+LFL ++ + G DGG
Sbjct: 237 QVILFLADRTMSSYIIGQSIIADGG 261
>CE12990 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 84.7 bits (208), Expect = 1e-16
Identities = 61/213 (28%), Positives = 106/213 (49%), Gaps = 15/213 (7%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-----DPSGSRVI 60
FAGK ++TG+S+G+G A GA V IT R+ +++ T + P V+
Sbjct: 4 FAGKSVIITGSSSGIGRATAVLFAKNGAQVTITGRNAEKLEATKKKLLKVVKTPDSVNVV 63
Query: 61 GKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNIN 120
++T A+ + +IQ ++FG + L+NNAG T D ID + + N
Sbjct: 64 --VANLTDAQGQDQIIQSAVKKFGKIDILINNAGANVVDGTVNTDQSIDLYHKTFQINFQ 121
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP-YTATKHAVIGITQSVAL 179
+K + +S+ +VN+S++ +SP Y A K A+ T+ VAL
Sbjct: 122 AVVEMVKKTKKYL-----IESKGEIVNVSSIAAGPQAVSMSPYYAAAKAALNQYTRCVAL 176
Query: 180 EYAERNVRVNAVAPGYVSTPKIQAL--PKETQQ 210
+ ++ VRVN+V+PG ++T + A+ P++ Q+
Sbjct: 177 DLIKQGVRVNSVSPGIIATNFMGAMGVPEQAQK 209
>CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 251
Score = 84.7 bits (208), Expect = 1e-16
Identities = 77/245 (31%), Positives = 122/245 (49%), Gaps = 26/245 (10%)
Query: 19 GVGEGIARALFVRGATVVITSRH----LSEVQETAG---NIDPSGSRVIGKEVDVTVAKA 71
G+G+ I +L GA V+ +R+ LS V+ET I P ++G DV+ A
Sbjct: 20 GIGKEICLSLAKAGAQVIAFARNEANLLSLVKETTSLRYTIIP----IVG---DVS---A 69
Query: 72 VEDLIQEIREEFGALHYLVNNAGITGPHQTG-IEDYDIDSWRQVIDTNINGTFYTLKYAL 130
E+++ ++ +H LVNNAGI H G I ID + N+ G + A
Sbjct: 70 NEEVLFKLIVPHFPIHGLVNNAGIATNHAIGQITQQSID---RTFAVNVRGP---ILIAQ 123
Query: 131 PLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRVNA 190
+ + + ++VN+S+ + + + Y A+K A+ +T+ +A E +N+RVN+
Sbjct: 124 LVARNFVDRQIKGSIVNISSQAAIRPLDNHTVYCASKAALDMVTRCLANELGSQNIRVNS 183
Query: 191 VAPGYVSTP--KIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTGSVYP 248
V P V T + + ++ M + P+KR A + EV N VLFLLS TTGS P
Sbjct: 184 VNPTVVMTDMGRDNWSDPDKKKKMLDRMPIKRFAEVDEVVNAVLFLLSDNASMTTGSTLP 243
Query: 249 IDGGF 253
+DGGF
Sbjct: 244 VDGGF 248
>CE05726 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 84.7 bits (208), Expect = 1e-16
Identities = 73/262 (27%), Positives = 118/262 (44%), Gaps = 21/262 (8%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+GK ++TG+S G+G A GA V IT R+ ++ET I +G ++
Sbjct: 4 FSGKSVIITGSSNGIGRSAAVIFAKEGAQVTITGRNEDRLEETKQQILKAGVPAEKINAV 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
DVT A +D+I +FG + LVNNAG T D ++ +++ N
Sbjct: 64 VADVTEASGQDDIINTTLAKFGKIDILVNNAGANLADGTANTDQPVELYQKTFKLNFQAV 123
Query: 123 F-YTLKYALPLMESSSSPDSEAAVVNLSA-VNGLVGIPGISPYTATKHAVIGITQSVALE 180
T K L++ ++ +VN+S+ V G G Y K A+ T+ A++
Sbjct: 124 IEMTQKTKEHLIK------TKGEIVNVSSIVAGPQAHSGYPYYACAKAALDQYTRCTAID 177
Query: 181 YAERNVRVNAVAPGYVSTPKIQA--LPKETQQWMSS-------QHPMKRMATMTEVSNTV 231
+ VRVN+V+PG V+T + A LP+ + S P+ E++N +
Sbjct: 178 LIQHGVRVNSVSPGAVATGFMGAMGLPETASDKLYSFIGSRKECIPVGHCGKPEEIANII 237
Query: 232 LFLLS-PLTGFTTGSVYPIDGG 252
+FL L+ + G DGG
Sbjct: 238 VFLADRNLSSYIIGQSIVADGG 259
>At5g50690 [Q] KOG1205 Predicted dehydrogenase
Length = 303
Score = 84.7 bits (208), Expect = 1e-16
Identities = 59/191 (30%), Positives = 98/191 (50%), Gaps = 10/191 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS-RVIGKEVDV 66
GK+ ++TG+S+G+GE +A RGA + + +R +Q A GS V DV
Sbjct: 47 GKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGDV 106
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDY-DIDSWRQVIDTNINGTFYT 125
+V K + +QE FG L +LVNNAGI EDY +I +++TN G Y
Sbjct: 107 SVIKDCKRFVQETISRFGRLDHLVNNAGIA--EAKFFEDYSEISDVLPIVNTNFWGPVYA 164
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+A+P ++ ++ ++ +++ G G+P +S Y A+K A+I +++ +E
Sbjct: 165 THFAIPHLKK-----TKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIE-LHPE 218
Query: 186 VRVNAVAPGYV 196
V V V PG +
Sbjct: 219 VGVTIVFPGLI 229
>At3g42960 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 272
Score = 84.7 bits (208), Expect = 1e-16
Identities = 68/259 (26%), Positives = 120/259 (46%), Gaps = 23/259 (8%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K+A++TG + G+G AR GA V++ +++ E G + DV+
Sbjct: 11 KVAIITGGARGIGAATARLFTENGAYVIV-----ADILENEGILVAESIGGCYVHCDVSK 65
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
VE ++ G L + NNAG++ ++ I D+D +++ N+NG + +K+
Sbjct: 66 EADVEAAVELAMRRKGRLDVMFNNAGMS-LNEGSIMGMDVDMVNKLVSVNVNGVLHGIKH 124
Query: 129 ALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRV 188
A M S ++ S+ +GL+G G YT +K A+ G+ ++ A E +RV
Sbjct: 125 AAKAMIKGGRGGS---IICTSSSSGLMGGLGGHAYTLSKGAINGVVRTTACELGSHGIRV 181
Query: 189 NAVAPGYVSTP-KIQALPK----------ETQQWMSSQHPM--KRMATMTEVSNTVLFLL 235
N+++P V T + A K E ++ + + R T+ +V+ LFL
Sbjct: 182 NSISPHGVPTDILVNAYRKFLNHDKLNVAEVTDIIAEKGSLLTGRAGTVEDVAQAALFLA 241
Query: 236 S-PLTGFTTGSVYPIDGGF 253
S +GF TG +DGG+
Sbjct: 242 SQESSGFITGHNLVVDGGY 260
>YMR226c [Q] KOG1205 Predicted dehydrogenase
Length = 267
Score = 84.3 bits (207), Expect = 1e-16
Identities = 62/199 (31%), Positives = 99/199 (49%), Gaps = 14/199 (7%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRG---ATVVITSRHLSEVQETAGNIDPS--GSRVIG 61
A K L+TGAS G+G+ A +++ +R L +++E ID ++V
Sbjct: 12 AKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHV 71
Query: 62 KEVDVTVAKAVEDLIQEIREEFGALHYLVNNAG-ITGPHQTG-IEDYDIDSWRQVIDTNI 119
++D+T A+ ++ I+ + +EF + LVNNAG G + G I DI + V DTN+
Sbjct: 72 AQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDI---QDVFDTNV 128
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVAL 179
+ LP+ ++ +S D +VNL ++ G P S Y A+K AV T S+
Sbjct: 129 TALINITQAVLPIFQAKNSGD----IVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRK 184
Query: 180 EYAERNVRVNAVAPGYVST 198
E +RV +APG V T
Sbjct: 185 ELINTKIRVILIAPGLVET 203
>Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 179
Score = 84.0 bits (206), Expect = 2e-16
Identities = 55/189 (29%), Positives = 97/189 (51%), Gaps = 15/189 (7%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K+ V G S G+G +A+ + +G + + +R+L + AG++ G + DV
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDL---GGDHLAFSCDVAK 59
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPH---QTGIEDYDIDSWRQVIDTNINGTFYT 125
V++ +E+ + G +++LVN AGI +T ED + TN+ G+ T
Sbjct: 60 EHDVQNTFEEMEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQ-----LHTNLLGSMLT 114
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
K A+ M ++VN+ ++ GL G G S Y+A+K ++G ++++A E A +
Sbjct: 115 CKAAMRTMIQQQG----GSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKK 170
Query: 186 VRVNAVAPG 194
+RVN VAPG
Sbjct: 171 IRVNVVAPG 179
>CE15574 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 84.0 bits (206), Expect = 2e-16
Identities = 76/264 (28%), Positives = 127/264 (47%), Gaps = 23/264 (8%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+GK+ALVTG+S G+G A L GA V IT R+ ++ET I SG V+
Sbjct: 4 FSGKVALVTGSSNGIGRATAILLAREGAKVTITGRNAQRLEETKQEILRSGVPEDHVLSI 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDY-DIDSWRQVIDTNING 121
D+ +L+ + FG L LVNNAG T +E + + + V D +
Sbjct: 64 IADLATESGQIELMNSTVDIFGRLDILVNNAGAA---ITDLEGHIGVGTNVSVFDKTMR- 119
Query: 122 TFYTLKYALPLMESSSSP--DSEAAVVNLSAV-NGLVGIPGISPYTATKHAVIGITQSVA 178
L+ + L + + ++ +VN+S++ G P + Y +K A+ T+S A
Sbjct: 120 --INLRSVVTLTQKAKEHLIKTKGEIVNVSSIAGGQHAQPELIYYAMSKSALDQYTRSAA 177
Query: 179 LEYAERNVRVNAVAPGYVSTP--KIQALPKET----QQWMSSQH---PMKRMATMTEVSN 229
++ + VRVN+V+PG + T + + KE+ ++M S+ P+ +A +V+N
Sbjct: 178 IDLIQHGVRVNSVSPGDIRTGIYETMGMNKESVENIYKFMESRKECCPIGTIAQPVDVAN 237
Query: 230 TVLFLLS-PLTGFTTGSVYPIDGG 252
++FL L+ + G DGG
Sbjct: 238 IIVFLADRKLSSYIIGQSIVADGG 261
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 83.6 bits (205), Expect = 3e-16
Identities = 61/231 (26%), Positives = 112/231 (48%), Gaps = 7/231 (3%)
Query: 8 GKIALVTGASTGVGEGIARALF-VRGATVVITSRHLSEVQETAGNIDPSGS-RVIGKEVD 65
GK L+TGAS+G+G+ A + V +++ +R S V+E A ++ V+ ++D
Sbjct: 6 GKTILITGASSGIGKSTAFEIAKVAKVKLILAARRFSTVEEIAKELESKYEVSVLPLKLD 65
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
V+ K++ +I+ + +EF + L+NNAG+ I D +ID +I TN+ G
Sbjct: 66 VSDLKSIPGVIESLPKEFADIDVLINNAGLALGTDKVI-DLNIDDAVTMITTNVLGMMAM 124
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+ LP+ S + D ++N+ ++ G G S Y +TK A+ T ++ E +
Sbjct: 125 TRAVLPIFYSKNKGD----ILNVGSIAGRESYVGGSVYCSTKSALAQFTSALRKETIDTR 180
Query: 186 VRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLS 236
+R+ V PG V T +Q + + T +++ +LF L+
Sbjct: 181 IRIMEVDPGLVETEFSVVRFHGDKQKADNVYKNSEPLTPEDIAEVILFALT 231
>CE12594 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 83.2 bits (204), Expect = 3e-16
Identities = 72/265 (27%), Positives = 121/265 (45%), Gaps = 27/265 (10%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+GK ++TG+S+G+G A GA V IT R ++ET I +G ++
Sbjct: 4 FSGKSIIITGSSSGIGRSAAVIFAKEGAQVTITGRSADRLEETRLQILKAGVPAEKINAV 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTN---- 118
DV A +++I+ +FG + LVNNAG T D ++ +++ N
Sbjct: 64 VADVCEASGQDEVIRTTLAKFGKIDILVNNAGALLTDGTSNTDQAVELYQKTFKLNFQAV 123
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSA-VNGLVGIPGISPYTATKHAVIGITQSV 177
+ T T +Y + ++ +VN+S+ V G P Y K A+ T+
Sbjct: 124 VEMTQKTKEYLI---------KTKGEIVNVSSIVAGPQAQPASPYYACAKAALDQYTRCT 174
Query: 178 ALEYAERNVRVNAVAPGYVSTPKIQA--LPKETQ----QWMSSQH---PMKRMATMTEVS 228
A++ + VRVN+V+PG ++T + A LP+ +M SQ P+ E++
Sbjct: 175 AIDLIQHGVRVNSVSPGVIATGFLGAMGLPETASDKFYNFMGSQKECIPVGHCGKPEEIA 234
Query: 229 NTVLFLLS-PLTGFTTGSVYPIDGG 252
N ++FL L+ + G DGG
Sbjct: 235 NIIVFLADRRLSSYIIGQSIVADGG 259
>CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 307
Score = 83.2 bits (204), Expect = 3e-16
Identities = 60/199 (30%), Positives = 97/199 (48%), Gaps = 13/199 (6%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV 64
S GK L+TG+ +G+G +A GA VVI + +ET + +G + V
Sbjct: 36 SVEGKKVLITGSGSGIGRLMALEFAKLGAEVVIWDVNKDGAEETKNQVVKAGGKASTFVV 95
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDI--DSWRQVIDTNINGT 122
D++ K + + +E +E G + L+NNAGI TG + +D + + + N N
Sbjct: 96 DLSQYKDIHKVAKETKEAVGDIDILINNAGIV----TGKKLFDCPDELMEKTMAVNTNAL 151
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE-Y 181
FYT K LP M + +V ++++ G G G+ Y A+KH IG S+A+E
Sbjct: 152 FYTAKNFLPSMLEKDN----GHLVTIASMAGKTGCVGLVDYCASKHGAIGCHDSIAMEIL 207
Query: 182 AERNVRVNA--VAPGYVST 198
A++ VN V P ++ T
Sbjct: 208 AQKKYGVNTTLVCPFFIDT 226
>At3g47350 [Q] KOG1205 Predicted dehydrogenase
Length = 308
Score = 83.2 bits (204), Expect = 3e-16
Identities = 54/193 (27%), Positives = 100/193 (50%), Gaps = 10/193 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS-RVIGKEVDV 66
GK+ L+TGAS+G+GE +A +GA + + +R ++ A GS VI DV
Sbjct: 46 GKVVLITGASSGIGEHVAYEYAKKGAKLALVARRKDRLEIVAETSRQLGSGDVIIIPGDV 105
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDY-DIDSWRQVIDTNINGTFYT 125
+ + + I E FG L +L+NNAG+ P ED+ I ++D N G+ Y
Sbjct: 106 SNVEDCKKFIDETIHHFGKLDHLINNAGV--PQTVIFEDFTQIQDANSIMDINFWGSTYI 163
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+A+P + S+ +V +S+ ++ + S Y+A+K A++ +++ +E + +
Sbjct: 164 TYFAIPHLRK-----SKGKIVVISSATAIIPLQAASVYSASKAALVKFFETLRVEISP-D 217
Query: 186 VRVNAVAPGYVST 198
+++ PG++ST
Sbjct: 218 IKITIALPGFIST 230
>CE03954 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 274
Score = 82.8 bits (203), Expect = 4e-16
Identities = 56/199 (28%), Positives = 96/199 (48%), Gaps = 11/199 (5%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F K+A++TG+S G+G A L GA V IT R + ++ET I +G + V
Sbjct: 4 FTDKVAIITGSSNGIGRATAVLLATDGAKVTITGRDAARLEETRQAILKAGISATNVNSV 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTG--IEDYDIDSWRQVIDTNIN 120
DVT A+ + LI ++FG ++ L+NNAG P G I++ ++ N+
Sbjct: 64 VADVTTAEGQDLLISSTLDKFGKINILINNAGANIPDSQGQTRTKCSIENLTKMFQLNLQ 123
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVN-GLVGIPGISPYTATKHAVIGITQSVAL 179
++ P + + +VN+S++ G P Y++ K A+ ++ A+
Sbjct: 124 SVVEMVQKVRPHLAK-----TRGEIVNISSIGAGPAAQPASPYYSSAKAALDQYSRCAAI 178
Query: 180 EYAERNVRVNAVAPGYVST 198
+ +R+N V PG+VST
Sbjct: 179 DLISEGIRINVVQPGFVST 197
>7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 320
Score = 82.8 bits (203), Expect = 4e-16
Identities = 55/195 (28%), Positives = 99/195 (50%), Gaps = 10/195 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
GK+ L+TG G+G+ +A GAT++ + +T I +G + G +VT
Sbjct: 58 GKVVLITGTGHGMGKEMALQYAKLGATILCWDVNEQTNNQTVKEIKNNGGKAFGYVCNVT 117
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
+ + +L Q++R+E G +H +VNNAGI H + ++ + R + + N+ F+ ++
Sbjct: 118 KREELIELAQKVRKEHGFIHVVVNNAGIMPCHP--LLEHTENEIRLMYEINVLSHFWIIQ 175
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER--- 184
LP M +E ++V LS+ GL G+ + PY TK AV G ++ E ++
Sbjct: 176 AFLPDMIER----NEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAALVEELRQKNPQ 231
Query: 185 -NVRVNAVAPGYVST 198
NV++ + P + T
Sbjct: 232 NNVKLTTIYPYMIDT 246
>CE26808_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 550
Score = 82.8 bits (203), Expect = 4e-16
Identities = 61/199 (30%), Positives = 96/199 (47%), Gaps = 11/199 (5%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+GK+ALVTG+S G+G A +GA V IT R+ ++ET I SG V+
Sbjct: 219 FSGKVALVTGSSNGIGRAAALLFAQQGAKVTITGRNAERLEETRQAILKSGVPAENVLAI 278
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAG--ITGPHQTGIEDYDIDSWRQVIDTNIN 120
D+ + DLI ++FG L LVNNAG + P D I+ + + N+
Sbjct: 279 AADLATDQGQTDLINGTLQKFGRLDILVNNAGAAVNDPQGRMGIDQQIEDFDKTFQINMR 338
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAV-NGLVGIPGISPYTATKHAVIGITQSVAL 179
++ A ++ ++N+S++ G P + Y +K A+ T+S A+
Sbjct: 339 SVVTLVQKA-----KEHLIKTKGEIINVSSIGGGPHAQPDMMYYGMSKAALDQFTRSTAI 393
Query: 180 EYAERNVRVNAVAPGYVST 198
+ VRVN+V+PG V T
Sbjct: 394 TLIQHGVRVNSVSPGGVYT 412
Score = 49.7 bits (117), Expect = 4e-06
Identities = 30/83 (36%), Positives = 42/83 (50%), Gaps = 3/83 (3%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+GK+ALVTG+S G+G A +GA V IT R+ ++ET I SG V+
Sbjct: 4 FSGKVALVTGSSNGIGRAAALLFAQQGAKVTITGRNAERLEETRQAILKSGVPAENVLAI 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGA 85
D+ + DLI + GA
Sbjct: 64 ATDLATDQGQTDLINGTLQNIGA 86
>CE21514 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 319
Score = 82.4 bits (202), Expect = 6e-16
Identities = 69/219 (31%), Positives = 109/219 (49%), Gaps = 21/219 (9%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRH----------LSEVQETAGNIDP 54
S AG+IA+VTGAS G+G GIA L GATV IT R LS ++ TA I
Sbjct: 2 SLAGQIAIVTGASRGIGRGIALQLGEAGATVYITGRKPEESLNSKVGLSGLEATADEITK 61
Query: 55 SGSRVIGKEVDVTVAKAVEDLIQEIREEF-GALHYLVNNA--GITG-PHQTGIEDYDIDS 110
G + I + VD + V++ + + +E G L LVNNA G+T G Y+ D
Sbjct: 62 RGGKGIARFVDHQNMEEVKNFFEVVEKEHQGQLDILVNNAYQGVTAISENMGKPFYETDP 121
Query: 111 --WRQVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKH 168
W + + + ++ YA LM + ++ +VN+S+ GL + ++ Y K
Sbjct: 122 YVWDTINNVGLRNHYFCTVYAARLMTAR----NKGLIVNVSSGGGLRYLFNVA-YGVGKQ 176
Query: 169 AVIGITQSVALEYAERNVRVNAVAPGYVSTPKIQALPKE 207
A+ ++ A+E ++NV V ++ PG V T + + K+
Sbjct: 177 ALDRMSADTAVELRKKNVCVVSIWPGAVRTELVDKMFKD 215
>CE03951 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 82.0 bits (201), Expect = 7e-16
Identities = 58/200 (29%), Positives = 100/200 (50%), Gaps = 13/200 (6%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGK 62
F+GK+A++TG+S G+G A GA V +T R +Q + + +G S +
Sbjct: 5 FSGKVAIITGSSFGIGRATALLFAKEGAKVTVTGRSEERLQGSKQALLDAGISDSNFLIV 64
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGIT---GPHQTGIEDYDIDSWRQVIDTNI 119
D+T + + LI + E+FG ++ LVNNAG + ++ G+ D ID++ +V+ N+
Sbjct: 65 PADITTSSGQDALISKTLEKFGQINILVNNAGASIADSQNRAGL-DQGIDTYEKVLKLNV 123
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP-YTATKHAVIGITQSVA 178
+ P + + +VN+S+V L +P Y K A+ T+S A
Sbjct: 124 QSVIEMTQKIRPHLAK-----TRGEIVNVSSVAALKFAHVRNPYYPLAKAALDQYTRSAA 178
Query: 179 LEYAERNVRVNAVAPGYVST 198
++ + +RVN V PG V+T
Sbjct: 179 IDLISQGIRVNTVNPGVVAT 198
>Hs20149619 [Q] KOG1205 Predicted dehydrogenase
Length = 325
Score = 81.6 bits (200), Expect = 1e-15
Identities = 54/195 (27%), Positives = 97/195 (49%), Gaps = 12/195 (6%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKE------ 63
+ ++TGA++G+G+ A+ + GA +V+ R+ ++E + S + +
Sbjct: 54 VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
D+T + A+ EI + FG + LVNNAGI+ ++ I D +D ++V++TN G
Sbjct: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGIS--YRGTIMDTTVDVDKRVMETNYFGPV 171
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
K LP M + +V +S++ G + IP S Y A+KHA + E +
Sbjct: 172 ALTKALLPSMIKRR----QGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQ 227
Query: 184 RNVRVNAVAPGYVST 198
+ V ++PGY+ T
Sbjct: 228 YEIEVTVISPGYIHT 242
>CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 368
Score = 79.7 bits (195), Expect = 4e-15
Identities = 53/200 (26%), Positives = 99/200 (49%), Gaps = 14/200 (7%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVV---ITSRHLSEVQETAGNIDPSGSRVIGKEVD 65
+ +TG +G G G+A +G V +T + + + A +G + +D
Sbjct: 70 RAVFITGCDSGFGRGLALKCLEQGMPVFAGCLTEQGIESLSAEARKSIGNGRSLDAFLMD 129
Query: 66 VTVAKAVEDLIQEIR---EEFGALHYLVNNAGITGPHQTGIEDY-DIDSWRQVIDTNING 121
VT ++V ++ + + E++G LH +VNNAGITG H +D+ DI+ + +V + N+ G
Sbjct: 130 VTSDESVGEVAKRLEKKCEQYGGLHAVVNNAGITGKHIA--DDFLDINEYLKVANINLWG 187
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY 181
T L++ + VV ++++ VG+PG+ PY+ +K+ V + E
Sbjct: 188 PIRTTMAVKKLLKKA-----RGRVVTVASICARVGLPGLGPYSVSKYGVSAYCDVIRQEL 242
Query: 182 AERNVRVNAVAPGYVSTPKI 201
+ V+ + PG+ +TP I
Sbjct: 243 RPFGISVHVLEPGFFNTPLI 262
>7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 321
Score = 79.0 bits (193), Expect = 6e-15
Identities = 63/202 (31%), Positives = 101/202 (49%), Gaps = 13/202 (6%)
Query: 3 EYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-DPSGSRVIG 61
+ S G+ A+VTG++ G+G+ A+ L RG +V+ SR L ++ A I D G V
Sbjct: 47 DLSKMGEWAVVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRV 106
Query: 62 KEVDVTVAKAVEDLIQEIREEFGALHY--LVNNAGITGPHQTGIED-YDIDS--WRQVID 116
+VD T + D +IRE+ L+ LVNN GI+ H D Y D R ++
Sbjct: 107 IDVDFTGGDEIYD---KIREKTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVA 163
Query: 117 TNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQS 176
NI+ + LP M S ++N+S+ G++ P +S Y++TK V +
Sbjct: 164 ANIHSVTHMTALFLPGMISQR----RGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDD 219
Query: 177 VALEYAERNVRVNAVAPGYVST 198
+ EY E + + +V PG+V+T
Sbjct: 220 LQTEYKEHGILIQSVQPGFVAT 241
>7294452 [Q] KOG1205 Predicted dehydrogenase
Length = 266
Score = 78.6 bits (192), Expect = 8e-15
Identities = 69/239 (28%), Positives = 112/239 (45%), Gaps = 19/239 (7%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNID-PSGSRVIGKEV 64
+ K+A+V+GAS G+G RAL G VV +R V++ + SR+ +
Sbjct: 18 WCNKVAVVSGASAGIGAACTRALIGAGMIVVGLARRHERVEKLRSGLSLEQQSRLHAIKC 77
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
D+T V + G + LV+NAGI G + D D + R I+TNI GT Y
Sbjct: 78 DITQEDQVLKAFDWTCRQLGGVDVLVSNAGIIGTGELSERD-DGPAMRSTIETNIMGTVY 136
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGL------VGIPGISPYTATKHAVIGITQSVA 178
++ + M+ +E VV +++V G +P ++ Y ATK A+ + +
Sbjct: 137 CVRESFRSMKRRG---TEGHVVIVNSVAGYQVPNLGPQLPSLNIYPATKFALRAMNEIYR 193
Query: 179 LEYAERN--VRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLL 235
E+ VRV+ V+PG V T LP++ Q + PM R +V++ VL+ +
Sbjct: 194 QEFQRHKTAVRVSTVSPGIVDT---VILPEQIQGIIKQHMPMLR---SDDVADAVLWAI 246
>At3g47360 [Q] KOG1205 Predicted dehydrogenase
Length = 309
Score = 78.2 bits (191), Expect = 1e-14
Identities = 58/195 (29%), Positives = 102/195 (51%), Gaps = 12/195 (6%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS-RVIGKEVD 65
A K+ L+TGAS+G+GE +A +GA + + +R ++ A GS VI D
Sbjct: 46 ARKVVLITGASSGIGEHVAYEYAKKGAYLALVARRRDRLEIVAETSRQLGSGNVIIIPGD 105
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGI-EDY-DIDSWRQVIDTNINGTF 123
V+ + + I E FG L +L+NNAG+ QT + ED+ I ++D N GT
Sbjct: 106 VSNVEDCKKFIDETIRHFGKLDHLINNAGV---FQTVLFEDFTQIQDANPIMDINFWGTT 162
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
Y +A+P + S+ +V +++ + + +P S Y A+K A++ +++ +E +
Sbjct: 163 YITYFAIPHLRK-----SKGKIVAITSGSANIPLPLASIYAASKAALLRFFETLRIELSP 217
Query: 184 RNVRVNAVAPGYVST 198
++++ V PG VST
Sbjct: 218 -DIKITIVLPGVVST 231
>7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 399
Score = 78.2 bits (191), Expect = 1e-14
Identities = 54/191 (28%), Positives = 92/191 (47%), Gaps = 11/191 (5%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVA 69
IAL+TG G+G +A L G VVI + + ET ++ +G G VD++
Sbjct: 88 IALITGGGNGLGRLLAERLGKMGTKVVIWDINKKGIAETVQIVEEAGGYCKGYVVDISKK 147
Query: 70 KAVEDLIQEIREEFGALHYLVNNAG-ITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
+ V IR+E G + L+NNAG ++G H D+ I+ + + N+ F+T K
Sbjct: 148 EEVYKAADVIRDEVGDITLLINNAGVVSGLHLLDTPDHLIE---RSFNVNVMAHFWTTKA 204
Query: 129 ALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE---YAERN 185
LP M + + ++++ G VGI + Y A+K A +G +++ LE N
Sbjct: 205 FLPKM----IENDRGHIATIASLAGHVGISKLVDYCASKFAAVGFDEALRLELEVLGHTN 260
Query: 186 VRVNAVAPGYV 196
+R + P ++
Sbjct: 261 IRTTCICPFFI 271
>7295621 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 78.2 bits (191), Expect = 1e-14
Identities = 65/244 (26%), Positives = 115/244 (46%), Gaps = 40/244 (16%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-DPSGSRVIGKEVDVTV 68
+A+VTGAS+G+G I R L G VV +R + +++ + SR+ + DV+
Sbjct: 8 VAVVTGASSGIGAAITRKLISAGVMVVALARRMDRLEQLREELPQDRRSRLRIMQCDVSD 67
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
+V + ++ + G + L+NNAG Q + +D+ +Q++ TN+ G Y +
Sbjct: 68 VSSVNAVFDAVQGDLGNVDILINNAGKLSGGQ--LLTMSVDTVQQMLQTNVMGVVYCTQR 125
Query: 129 ALPLMESSSSPDSEAAVVNLSAVNGLVG------IPG----ISPYTATKHAVIGITQSVA 178
A ES S+ VV +N +VG +PG ++ Y ATKHA+ +T+
Sbjct: 126 A---FESMRQRQSKGHVV---LINSIVGHYIFNPLPGSQQELNMYPATKHAITALTELFR 179
Query: 179 LEYAE--RNVRVNAVAPGYVSTPKI----QALPKETQQWMSSQHPMKRMATMTEVSNTVL 232
E + V+V +++PG V T + + LP M +V+N ++
Sbjct: 180 QEMRDFKTKVKVTSISPGLVDTELVPLDYKGLP---------------MLQAEDVANAIM 224
Query: 233 FLLS 236
++LS
Sbjct: 225 YVLS 228
>7292690 [Q] KOG1205 Predicted dehydrogenase
Length = 251
Score = 78.2 bits (191), Expect = 1e-14
Identities = 54/195 (27%), Positives = 97/195 (49%), Gaps = 5/195 (2%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNID-PSGSRVIGKEVDVT 67
++A+VTGAS+G+G + L +G VV +R +QE ++ SR G++ DV+
Sbjct: 7 RVAVVTGASSGIGAACCKDLVSKGLVVVGLARREDRLQELKASLPADQASRFHGRKCDVS 66
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
+ V D I G LVNNAGI + + R ++DTN+ G + +
Sbjct: 67 QEQEVIDAFAWIDATLGGADVLVNNAGIVRLGVGITHEGNGADLRAILDTNVLGVSWCTR 126
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLVGIPGIS--PYTATKHAVIGITQSVALEY--AE 183
A ++ + D +VN A + ++ PGI+ Y+ +K+AV +T+ + E+ +
Sbjct: 127 EAFKSLKRRNVNDGHILIVNSVAGHRVINNPGITMGMYSPSKYAVTALTEVLRQEFHNNK 186
Query: 184 RNVRVNAVAPGYVST 198
++ +++PG V T
Sbjct: 187 TQTKITSISPGAVDT 201
>SPCC162.03 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 77.8 bits (190), Expect = 1e-14
Identities = 55/190 (28%), Positives = 93/190 (48%), Gaps = 17/190 (8%)
Query: 12 LVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVAKA 71
L+TG+S G+G + + +G V+ SR I S+++ ++DVT K+
Sbjct: 9 LITGSSKGLGYALVKVGLAQGYNVIACSR-------APDTITIEHSKLLKLKLDVTDVKS 61
Query: 72 VEDLIQEIREEFGALHYLVNNA--GITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKYA 129
VE ++ + FG + ++NNA G+ G E Y+I+ + ++ N G Y K A
Sbjct: 62 VETAFKDAKRRFGNVDIVINNAGYGLVGE----FESYNIEEMHRQMNVNFWGVAYITKEA 117
Query: 130 LPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER-NVRV 188
L LM S ++ +S+V G P +S Y A+K AV G++Q++ E N+ +
Sbjct: 118 LNLMRESG---KGGRILQISSVAGYYPSPCLSMYNASKFAVEGLSQTIMRELDPNWNIAI 174
Query: 189 NAVAPGYVST 198
V PG + T
Sbjct: 175 TIVQPGGMQT 184
>SPAC22A12.17c [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 77.8 bits (190), Expect = 1e-14
Identities = 67/251 (26%), Positives = 111/251 (43%), Gaps = 12/251 (4%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV 64
S GK A+V G + G+G I GA I + +G + +
Sbjct: 18 SLKGKNAVVFGGARGIGHAICSVFAEAGANAFIVYNTTPGEKAAKEIAQANGVKTYTCKC 77
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGI-TGPHQTGIEDYDIDSWRQVIDTNINGTF 123
DVT+ K VE EI++ F + +V N GI TG D + + I+ N+ G F
Sbjct: 78 DVTIPKEVEHAFAEIQKVFDTIDIVVPNNGICTGKSAI---DMTYEEFANEINVNLLGVF 134
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGIS-PYTATKHAVIGITQSVALEYA 182
A P+ + S A ++S V +V +P Y +K VI + +S+A+E+
Sbjct: 135 NVAHNAGPIFQKQGH-GSLVATASMSGV--VVNVPQQQCAYNTSKAGVIQLIKSLAVEW- 190
Query: 183 ERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFT 242
+ RVN V+PGY ++ K ++W P +R E+++ L+L S +
Sbjct: 191 RKFARVNCVSPGYTTSDMTGG--KFHKEW-EPYTPFERNGLAKEIASAYLYLASDAASYA 247
Query: 243 TGSVYPIDGGF 253
+G+ +DGG+
Sbjct: 248 SGTNLIVDGGY 258
>Hs7706318 [Q] KOG1205 Predicted dehydrogenase
Length = 339
Score = 77.4 bits (189), Expect = 2e-14
Identities = 53/201 (26%), Positives = 102/201 (50%), Gaps = 11/201 (5%)
Query: 3 EYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS----R 58
E+ + VTGAS+G+GE +A L G ++V+++R + E++ +G+
Sbjct: 45 EWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKD 104
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTN 118
++ +D+T + E + + +EFG + LVNN G++ ++ D +D +R++I+ N
Sbjct: 105 ILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMS--QRSLCMDTSLDVYRKLIELN 162
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA 178
GT K LP M + +V ++++ G++ +P Y A+KHA+ G +
Sbjct: 163 YLGTVSLTKCVLPHMIER----KQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLR 218
Query: 179 LEYAE-RNVRVNAVAPGYVST 198
E A + V+ + PG V +
Sbjct: 219 TELATYPGIIVSNICPGPVQS 239
>7290386 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 176
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/180 (35%), Positives = 89/180 (49%), Gaps = 15/180 (8%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVI 60
MS AGK+ALVTGA +G+G R L GA V+ R+L QET + S +
Sbjct: 1 MSVGVLAGKVALVTGAGSGIGRATCRLLARDGAKVIAVDRNLKAAQETVQELGSERSAAL 60
Query: 61 GKEVDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPH---QTGIEDYDIDSWRQVID 116
EVDV+ A++V+ + E ++F A +VN+AGIT + DYD V
Sbjct: 61 --EVDVSSAQSVQFSVAEALKKFQQAPTIVVNSAGITRDGYLLKMPERDYD-----DVYG 113
Query: 117 TNINGTF-YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQ 175
N+ GTF T YA ++E +VNLS++ + G + Y ATK VI T+
Sbjct: 114 VNLKGTFLVTQAYAKAMIEQKL---ENGTIVNLSSIVAKMNNVGQANYAATKAGVISFTE 170
>7300831 [Q] KOG1205 Predicted dehydrogenase
Length = 248
Score = 76.6 bits (187), Expect = 3e-14
Identities = 56/203 (27%), Positives = 101/203 (49%), Gaps = 12/203 (5%)
Query: 2 SEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIG 61
+ + + K+A+VTGAS G+G A L G VV +R + ++ + G ++
Sbjct: 3 NNFYWRNKVAVVTGASVGIGATTAIELANAGMVVVGLARRVELIEALRDQVTGVG-KIFA 61
Query: 62 KEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNING 121
++ D+ + + IRE+F A+H L+ NAGI + + +++ DTN+
Sbjct: 62 RQCDLNDEEQLASAFNWIREKFQAIHVLICNAGIL--KANFLSESPTKDIKELFDTNVVA 119
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSAVNG----LVGIPGISPYTATKHAVIGITQSV 177
T L+ AL M ++ +V +++V G V +P S Y ATKHA+ + Q+V
Sbjct: 120 TASCLREALKHM---AAVKVRGHIVVMNSVLGHRIPEVPVPLFSVYPATKHAITALCQTV 176
Query: 178 ALE--YAERNVRVNAVAPGYVST 198
E + + N+++ ++ PG V T
Sbjct: 177 RQEIHFLKLNIKLTSICPGMVDT 199
>YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 900
Score = 75.9 bits (185), Expect = 5e-14
Identities = 67/260 (25%), Positives = 117/260 (44%), Gaps = 26/260 (10%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVIT--------SRHLSEVQETAGNIDPSG 56
SF ++ ++TGA G+G+ A A RGA VV+ S H S+ + +
Sbjct: 6 SFKDRVVVITGAGGGLGKVYALAYASRGAKVVVNDLGGTLGGSGHNSKAADLVVDEIKKA 65
Query: 57 SRVIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVID 116
+ D +V + E +I+ +EFG + L+NNAGI + V+D
Sbjct: 66 GGIAVANYD-SVNENGEKIIETAIKEFGRVDVLINNAGIL--RDVSFAKMTEREFASVVD 122
Query: 117 TNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQS 176
++ G + + A P M S ++N ++ GL G G + Y+A K ++G+ ++
Sbjct: 123 VHLTGGYKLSRAAWPYMRSQKF----GRIINTASPAGLFGNFGQANYSAAKMGLVGLAET 178
Query: 177 VALEYAERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLS 236
+A E A+ N+ VN++AP S LP H +K++ ++ VL+L
Sbjct: 179 LAKEGAKYNINVNSIAPLARSRMTENVLP---------PHILKQLGP-EKIVPLVLYLTH 228
Query: 237 PLTGFTTGSVYPIDGGFLAQ 256
T + S++ + GF Q
Sbjct: 229 ESTK-VSNSIFELAAGFFGQ 247
Score = 69.7 bits (169), Expect = 4e-12
Identities = 54/190 (28%), Positives = 87/190 (45%), Gaps = 10/190 (5%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITS-RHLSEVQETAGNIDPSGSRVIGKE 63
S K+ +VTGA G+G+ A GA VV+ + V E + G+ +
Sbjct: 319 SLCNKVVVVTGAGGGLGKSHAIWFARYGAKVVVNDIKDPFSVVEEINKLYGEGTAIPDSH 378
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
VT A + IQ +F + LVNNAGI + W V+ ++ TF
Sbjct: 379 DVVTEAPLI---IQTAISKFQRVDILVNNAGIL--RDKSFLKMKDEEWFAVLKVHLFSTF 433
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
K P+ S ++N ++ +G+ G G + Y A K A++G ++++ALE A+
Sbjct: 434 SLSKAVWPIFTKQKS----GFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTIALEGAK 489
Query: 184 RNVRVNAVAP 193
R + VN +AP
Sbjct: 490 RGIIVNVIAP 499
>At4g09750 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 322
Score = 75.5 bits (184), Expect = 7e-14
Identities = 64/257 (24%), Positives = 118/257 (45%), Gaps = 31/257 (12%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPS-GSRVIGKEV-D 65
GK +VTGA++G+G A L RGATV + R+ QE I S G++ + EV D
Sbjct: 43 GKNCVVTGANSGIGFAAAEGLASRGATVYMVCRNKERGQEALSKIQTSTGNQNVYLEVCD 102
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
++ ++ + +H LVNNAG+ +T + + N+ GT+
Sbjct: 103 LSSVNEIKSFASSFASKDVPVHVLVNNAGLLENKRTTTP----EGFELSFAVNVLGTYTM 158
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIP-------------GISPYTATKHAVIG 172
+ LPL+E ++PD++ V A G+ P G+ Y K +
Sbjct: 159 TELMLPLLE-KATPDAKVITV---ASGGMYTSPLTTDLQFSGEKFDGVEQYARNKRIQVA 214
Query: 173 ITQSVALEYAERNVRVNAVAPGYVSTPKI-QALPKETQQWMSSQHPMKRMATMTEVSNTV 231
+T+ A +Y + + ++ PG+ TP + ++LP ++ + ++ T + ++T+
Sbjct: 215 LTEKWADKYKNKGIGFYSMHPGWAETPGVAKSLPSFSESFAG------KLRTSEQGADTI 268
Query: 232 LFL-LSPLTGFTTGSVY 247
++L L P +G+ Y
Sbjct: 269 VWLALQPKEKLVSGAFY 285
>7297069 [Q] KOG1205 Predicted dehydrogenase
Length = 246
Score = 75.5 bits (184), Expect = 7e-14
Identities = 56/197 (28%), Positives = 95/197 (47%), Gaps = 9/197 (4%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPS-GSRVIGKEVDVT 67
K+A+VTGAS G+G ARA+ G VV +R ++++E ++ + I + DV+
Sbjct: 7 KLAVVTGASGGIGAACARAMIGAGLRVVGLARREAKLKELRESLPRELQANFIPRRCDVS 66
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
V+ I E L+NNAGIT + + + ++VIDTN+ G + +
Sbjct: 67 KEDQVQSSFDWIERELEGADVLLNNAGITRETEL-VTPSNTQKLKEVIDTNVMGVIWCTR 125
Query: 128 YALPLMESSSSPDSEAAVVNLSA----VNGLVGIPGISPYTATKHAVIGITQSVALEYA- 182
A M+ + ++N A +N + +P + Y ATK A+ IT++ E+
Sbjct: 126 EAFNNMKRRGG-EGHVLIINSIAGHQVLNFIDVLPSFNIYPATKFAITAITETYRQEFQL 184
Query: 183 -ERNVRVNAVAPGYVST 198
+RV + PG V+T
Sbjct: 185 HSNKIRVTGICPGAVNT 201
>7292613 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 74.3 bits (181), Expect = 2e-13
Identities = 56/200 (28%), Positives = 96/200 (48%), Gaps = 15/200 (7%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNID-PSGSRVIGKEVDVT 67
++A+VTGAS+G+G IA+ L + G TVV +R + V+E + ++ DV
Sbjct: 7 RVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRVKELQRELPAEKRGKLFALYCDVG 66
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
+V + I ++ GA+ LVNNAG P + D + +QV+ TNI G +
Sbjct: 67 NESSVNEAFDWIIQKLGAIDVLVNNAGTLQPGY--LVDMNPAVMQQVLQTNIMGIVLCTQ 124
Query: 128 YALPLMESSSSPDSEAAVVN-------LSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
A+ M D ++N ++A G+ P ++ Y +KHAV + + E
Sbjct: 125 RAVRSMRERKF-DGHVVLINSILGHKTMTATEGVA--PDVNVYPPSKHAVTALAEGYRQE 181
Query: 181 Y--AERNVRVNAVAPGYVST 198
+ +++ +V+PG V T
Sbjct: 182 FFGLGTRIKITSVSPGVVDT 201
>At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 305
Score = 74.3 bits (181), Expect = 2e-13
Identities = 53/207 (25%), Positives = 96/207 (45%), Gaps = 14/207 (6%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSR--------- 58
G ALVTG ++G+G + AL +G V + + QET + + ++
Sbjct: 6 GLSALVTGGASGIGRALCLALAEKGVFVTVADFSEEKGQETTSLVREANAKFHQGLSFPS 65
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYD-IDSWRQVIDT 117
I + DVT + + FG L +NNAGI+ P + +D D SW+ I+
Sbjct: 66 AIFVKCDVTNRGDLLAAFDKHLATFGTLDICINNAGISTPLRFDKDDTDGSKSWKHTINV 125
Query: 118 NINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV 177
++ + A+ M++ P ++N+ + GL +P Y A+K V+ T+S+
Sbjct: 126 DLIAVVEGTQLAIKAMKAKQKP---GVIINMGSAAGLYPMPVDPIYAASKAGVVLFTRSL 182
Query: 178 ALEYAERNVRVNAVAPGYVSTPKIQAL 204
A Y + +R+N + P ++ T +A+
Sbjct: 183 AY-YRRQGIRINVLCPEFIKTDLAEAI 208
>At3g03330 [Q] KOG1205 Predicted dehydrogenase
Length = 345
Score = 73.9 bits (180), Expect = 2e-13
Identities = 51/197 (25%), Positives = 98/197 (48%), Gaps = 12/197 (6%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQ----ETAGNIDPSGSRVIGKE 63
GK+ +TGAS G+GE +A+ A +++++R+ +E+ E G P +V+ +
Sbjct: 43 GKVVWITGASRGIGEILAKQFASLDAKLILSARNKAELDRVKSELKGKFAPEDVKVLPLD 102
Query: 64 VDVTVAKAVEDLIQEIREEF--GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNING 121
+ + ++++ ++++ F + YLV+NA P ++ D ++ + D N+ G
Sbjct: 103 L-ASGEESLKHVVEQAVSLFPGAGVDYLVHNAAFERP-KSKASDASEETLKTTFDVNVFG 160
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY 181
T K P M V +S+ G V PG + Y+A+KHA+ G S+ E+
Sbjct: 161 TISLTKLVAPHMLKQGG----GHFVVISSAAGKVPSPGQAIYSASKHALHGYFHSLRSEF 216
Query: 182 AERNVRVNAVAPGYVST 198
++ ++V V PG + T
Sbjct: 217 CQKGIKVTVVCPGPIET 233
>7293189 [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 598
Score = 73.9 bits (180), Expect = 2e-13
Identities = 59/206 (28%), Positives = 91/206 (43%), Gaps = 12/206 (5%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITS---RHLSE-VQETAGNIDPSGSRVIG 61
+ G++A+VTGA G+G A RGA VV+ H + + A +I R G
Sbjct: 10 YDGRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAG 69
Query: 62 KEVDVTVAKAVED--LIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNI 119
E ++ +I+ + FG + LVNNAGI + W V D ++
Sbjct: 70 GEAVADYNSVIDGAKVIETAIKAFGRVDILVNNAGIL--RDRSLVKTSEQDWNLVNDVHL 127
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVAL 179
G+F + A P M+ + ++ S+ +G+ G G YTA K +IG+ +VA+
Sbjct: 128 KGSFKCTQAAFPYMKKQNY----GRIIMTSSNSGIYGNFGQVNYTAAKMGLIGLANTVAI 183
Query: 180 EYAERNVRVNAVAPGYVSTPKIQALP 205
E A NV N + P S LP
Sbjct: 184 EGARNNVLCNVIVPTAASRMTEGILP 209
>7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 336
Score = 73.6 bits (179), Expect = 3e-13
Identities = 55/215 (25%), Positives = 105/215 (48%), Gaps = 17/215 (7%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGK-- 62
S G+ +VTG S G+G +A ++GA V + +R + ++ R K
Sbjct: 32 SIVGRHVVVTGGSKGIGLCLAVECAMKGANVTVIARDEKMLSGAVALMEVIRQRPDQKFQ 91
Query: 63 --EVDVTVA-KAVEDLIQEIREEFGALHYLVNNAGITGPHQTGI-EDYDIDSWRQVIDTN 118
+D++ V ++ EI + FG ++ L+N AG+ G+ E+ + ++++ N
Sbjct: 92 YRSLDISGDYDQVAKVLGEIEDSFGPIYTLINCAGMA---ICGVFEEVSVQDVHKLMNVN 148
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA 178
GT+ +Y LP M+ + + +V ++ + GI G PY+ATK+A+ + +++A
Sbjct: 149 FFGTYNCTRYVLPKMKKAG----DGIIVITASQAAMFGIYGYGPYSATKYALRAMAETIA 204
Query: 179 LEYAERNVRVNAVAPGYVSTPKIQ----ALPKETQ 209
+E E V V P +TP + + P+ET+
Sbjct: 205 MESREHGVSVTLAMPCDTNTPGFEEEEKSKPRETK 239
>CE07544 [Q] KOG1205 Predicted dehydrogenase
Length = 262
Score = 73.2 bits (178), Expect = 3e-13
Identities = 52/190 (27%), Positives = 98/190 (51%), Gaps = 12/190 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K+ ++TGAS+G+G+ +A L+ RGA V++ +R +++E + + + + +
Sbjct: 48 KVVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICEELKETFP--LNQNEPIYY 105
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
+ D Q E + L+NNAG++ ++ +D ++ RQ ++TN G + +
Sbjct: 106 YFDITDSEQAPWAEIPRVDILINNAGMS--NRGSCQDTTMEIHRQAMETNYFGHVHVTQA 163
Query: 129 ALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRV 188
L S SPD +V S++ G V IP Y A+KHA+ G + E+ +N+ +
Sbjct: 164 LL----SKLSPD--GCIVVTSSIQGKVAIPYRGSYGASKHALQGYFDCLRAEH--KNLHI 215
Query: 189 NAVAPGYVST 198
V+ GY++T
Sbjct: 216 LVVSAGYINT 225
>YIR036c [Q] KOG1204 Predicted dehydrogenase
Length = 263
Score = 72.8 bits (177), Expect = 4e-13
Identities = 50/194 (25%), Positives = 91/194 (46%), Gaps = 6/194 (3%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
GK+ L+TGAS G+G + + + ++ +E + + + + + +D+T
Sbjct: 2 GKVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQREYGADKFVYRVLDIT 61
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQT---GIEDYDIDSWRQVIDTNINGTFY 124
+E L++EIR++ G L +V NAG+ P ++ ++DI W ++ D N
Sbjct: 62 DRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIVS 121
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER 184
+ LPL++SS + +V +S+ + G S Y +K A+ +A E
Sbjct: 122 LVALCLPLLKSSPFVGN---IVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSD 178
Query: 185 NVRVNAVAPGYVST 198
VR +APG V T
Sbjct: 179 KVRAVCIAPGVVDT 192
>SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 296
Score = 72.8 bits (177), Expect = 4e-13
Identities = 61/205 (29%), Positives = 104/205 (49%), Gaps = 18/205 (8%)
Query: 7 AGKIALVTGASTG-VGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVD 65
A K L+TG S G +G +A G V+ T+R + E N+ +G + + ++D
Sbjct: 3 AEKFVLITGCSEGGIGNALALKFHQEGFQVLATARQV----ERMDNLTKAGLQTL--KLD 56
Query: 66 VTVAKAVEDLIQEIRE-EFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
VT +V ++ QE+R+ G+LHYL+NNAG P D DI+ +V+D N G
Sbjct: 57 VTDEDSVREVEQEVRKFTNGSLHYLINNAG--APCSAPAIDLDIEDVSKVMDVNFYGVIR 114
Query: 125 TLK-YALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
K + L+ + + +VN++++ V + Y A+K A++ + ++ +E A
Sbjct: 115 MNKAFQHQLIRAKGT------IVNVNSLVSYVPFAFNAAYNASKAALLAYSNTLRIELAP 168
Query: 184 RNVRVNAVAPGYVSTPKIQALPKET 208
V+V ++ G V T KIQ+ P T
Sbjct: 169 FGVQVTSIMTGGVQT-KIQSKPLGT 192
>At5g61830 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 72.8 bits (177), Expect = 4e-13
Identities = 52/148 (35%), Positives = 81/148 (54%), Gaps = 8/148 (5%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVDVT 67
+A+VTG++ G+G IAR L V G TVV+T+R+++ E ++ G +V ++DVT
Sbjct: 38 VAVVTGSNRGIGFEIARQLAVHGLTVVLTARNVNAGLEAVKSLRHQEEGLKVYFHQLDVT 97
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
+ ++ + +++ FG L LVNNAG+ + G D ++ VI TN GT K
Sbjct: 98 DSSSIREFGCWLKQTFGGLDILVNNAGVN--YNLG-SDNTVEFAETVISTNYQGTKNMTK 154
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLV 155
+PLM S A VVN+S+ G V
Sbjct: 155 AMIPLMRPS---PHGARVVNVSSRLGRV 179
>At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 299
Score = 72.0 bits (175), Expect = 8e-13
Identities = 57/208 (27%), Positives = 96/208 (45%), Gaps = 28/208 (13%)
Query: 10 IALVTGASTG-VGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
+ L+TG S G +G +AR +G VV TSR S + + + SR+ KE+DV
Sbjct: 9 VVLITGCSQGGIGHALAREFTEKGCRVVATSRSRSTMTDLEQD-----SRLFVKELDVQS 63
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGI--TGPHQTGIEDYDIDSWRQVIDTNINGT---F 123
+ V ++ E+ ++FG + LVNNAG+ GP + + I + +TN+ G
Sbjct: 64 DQNVSKVLSEVIDKFGKIDVLVNNAGVQCVGP----LAETPISAMENTFNTNVFGNKDLI 119
Query: 124 YTLKYALPLMESSSS-------------PDSEAAVVNLSAVNGLVGIPGISPYTATKHAV 170
++ Y + +SS + +VN+ ++ + P YTATK A+
Sbjct: 120 FSFNYYIYWSFNSSGSMRMTQAVVPHMVSKKKGKIVNVGSITVMAPGPWAGVYTATKAAI 179
Query: 171 IGITQSVALEYAERNVRVNAVAPGYVST 198
+T ++ LE + V V PG + T
Sbjct: 180 HALTDTLRLELRPFGIDVINVVPGGIRT 207
>7304180 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 327
Score = 72.0 bits (175), Expect = 8e-13
Identities = 56/203 (27%), Positives = 93/203 (45%), Gaps = 18/203 (8%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVD 65
GK+A+VTG +TG+G+ L RGATV + R+ +V+ I + S V +E D
Sbjct: 45 GKVAIVTGGNTGLGKETVMELARRGATVYMACRNKEKVERARREIVKETGNSNVFSRECD 104
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGI-TGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
++ ++ + ++E LH L+NNAG+ PH+ E +++ + N G F
Sbjct: 105 LSSLDSIRKFAENFKKEQRVLHILINNAGVFWEPHRLTKEGFEMH-----LGVNHIGHFL 159
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGIS---------PYTATKHAVIGITQ 175
L ++E S+P V + + G + + I+ Y +K A I T+
Sbjct: 160 LTNLLLGVLE-RSAPSRVVVVASRAHERGQIKVDDINSSDFYDEGVAYCQSKLANILFTR 218
Query: 176 SVALEYAERNVRVNAVAPGYVST 198
+A V VNA+ PG T
Sbjct: 219 ELAKRLEGTGVTVNALNPGIADT 241
>7300731 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 71.2 bits (173), Expect = 1e-12
Identities = 52/201 (25%), Positives = 94/201 (45%), Gaps = 8/201 (3%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNID-PSGSRVIGKEVDVT 67
++A+VTGAS G+G R L +G VV +R +Q+ ++ +R + DV+
Sbjct: 7 RVAVVTGASAGIGAACCRDLVAKGMVVVGLARREKVLQDIKSSLPADQAARFHTRPCDVS 66
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDS-WRQVIDTNINGTFYTL 126
+ V D I G LVNNAGI Q I D + + R ++D N+ G +
Sbjct: 67 NEQQVIDTFAWIDRTLGGADVLVNNAGII--RQMNITDPENSADVRAILDVNVLGVTWCT 124
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGIS--PYTATKHAVIGITQSVALEYAER 184
+ ++ D V+N + + + G S Y +KHA+ +T+ + E+ ++
Sbjct: 125 RQWFLSLQRRKVNDGHVVVINSVVGHSVPAVEGFSLNMYAPSKHAITALTEILRQEFIKK 184
Query: 185 --NVRVNAVAPGYVSTPKIQA 203
++ +++PG V+T +A
Sbjct: 185 GTQTKITSISPGVVATEIFEA 205
>7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 339
Score = 70.9 bits (172), Expect = 2e-12
Identities = 55/193 (28%), Positives = 93/193 (47%), Gaps = 8/193 (4%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
G+ A+VTGA+ G+G+ AR L +G +V+ SR ++ I+ S +V K +
Sbjct: 70 GQWAVVTGATDGIGKEYARELARQGINLVLISRTKEKLIAVTNEIE-SQYKVKTKWIAAD 128
Query: 68 VAKAVEDLIQEIREEFGALHY--LVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
AK E + +I +E + LVNN G+ H ++ D ++ N+
Sbjct: 129 FAKGRE-VYDQIEKELAGIDVGILVNNVGMMYEHPESLDLVSEDLLWNLLTVNMGSVTML 187
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+ LP M + A+VNL + + L +P ++ Y A+K V ++++ LE AE N
Sbjct: 188 TRKILPQMIGRR----KGAIVNLGSSSELQPLPNMTVYAASKKFVTYFSKALELEVAEHN 243
Query: 186 VRVNAVAPGYVST 198
+ V V P +V T
Sbjct: 244 IHVQLVMPNFVVT 256
>Hs19923983 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 313
Score = 70.5 bits (171), Expect = 2e-12
Identities = 56/197 (28%), Positives = 84/197 (42%), Gaps = 11/197 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
G++ +VTGAS G+G GIA L GATV IT RHL ++ A G + + D +
Sbjct: 7 GQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSS 66
Query: 68 VAKAVEDLIQEI-REEFGALHYLVNNA-----GITGPHQTGIEDYDIDSWRQVIDTNING 121
V L +++ RE+ G L LVNNA I + W + + + G
Sbjct: 67 QESEVRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKAFWETPASMWDDINNVGLRG 126
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY 181
++ Y LM P + +V +S+ L + + PY K A + A E
Sbjct: 127 HYFCSVYGARLM----VPAGQGLIVVISSPGSLQYMFNV-PYGVGKAACDKLAADCAHEL 181
Query: 182 AERNVRVNAVAPGYVST 198
V ++ PG V T
Sbjct: 182 RRHGVSCVSLWPGIVQT 198
>At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 327
Score = 70.5 bits (171), Expect = 2e-12
Identities = 53/190 (27%), Positives = 93/190 (48%), Gaps = 8/190 (4%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNID-PSGSRVIGKEVDVTVA 69
A +TG S+G+G +A GA V I +R S+++E +I +G V DV
Sbjct: 42 AFITGGSSGIGLALAHRAASEGARVSILARSGSKLEEAKKSIQLATGVEVATFSADVRDY 101
Query: 70 KAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKYA 129
AV I +E G + L+ N G+ + + + + + ID N+ G+F +K A
Sbjct: 102 DAVSKAI----DESGPIDVLIVNQGVFTAKE--LVKHSPEDVKFTIDVNLVGSFNVIKAA 155
Query: 130 LPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRVN 189
LP M++ A++ +S+ G VG+ G + Y+A+K + G+ Q++ E ++ V
Sbjct: 156 LPAMKARKDR-GPASISLVSSQAGQVGVYGYAAYSASKFGLQGLAQALQQEVISDDIHVT 214
Query: 190 AVAPGYVSTP 199
+ P +TP
Sbjct: 215 LIFPPDTNTP 224
>SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase
Length = 247
Score = 70.1 bits (170), Expect = 3e-12
Identities = 57/193 (29%), Positives = 94/193 (48%), Gaps = 13/193 (6%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
A K+ L+TG+S G+G A AL + A V+ SR L+ ET +P + +V
Sbjct: 5 AEKVILLTGSSKGIGLATAEAL-QKKAKVIAVSRSLTPELETLLIQNPDSFVHVKGDVTE 63
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
++E I++ FG L ++ NAG+ P I D DI+ WR++ D N T+
Sbjct: 64 VGKASIETAIKK----FGKLDSVILNAGVLEPIAK-IADADINEWRKLFDINFFSVVETV 118
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
KYA+P + ++ +V +S+ + P + Y +K A+ + ++ E E ++
Sbjct: 119 KYAIPHLRK-----TKGTIVIVSSGAAVRVFPAWAAYCCSKAAINMLVMNLGSE--EPDI 171
Query: 187 RVNAVAPGYVSTP 199
AV PG V TP
Sbjct: 172 MSVAVRPGVVDTP 184
>Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 70.1 bits (170), Expect = 3e-12
Identities = 52/198 (26%), Positives = 93/198 (46%), Gaps = 11/198 (5%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV 64
S AG+I L+TGA G+G R + +V+ + V+ETA G V
Sbjct: 33 SVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVV 92
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQ-TGIEDYDIDSWRQVIDTNINGTF 123
D + + + + ++++E G + +VNNAG P +D +I + + NI G F
Sbjct: 93 DCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEI---TKTFEVNILGHF 149
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE--- 180
+ K LP M + +V +++V G GIP + PY ++K A +G + + E
Sbjct: 150 WITKALLPSMMER----NHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQA 205
Query: 181 YAERNVRVNAVAPGYVST 198
+ ++ + + P +V+T
Sbjct: 206 LGKTGIKTSCLCPVFVNT 223
>CE14538 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 70.1 bits (170), Expect = 3e-12
Identities = 54/200 (27%), Positives = 92/200 (46%), Gaps = 13/200 (6%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI----DPSGSRVIG 61
F ++A+VTG+S G+G A L GA V IT R+ ++E+ + PSG +
Sbjct: 5 FTDEVAIVTGSSNGIGRATAILLASEGAKVTITGRNAERLEESRQALLKVGVPSG-HINS 63
Query: 62 KEVDVTVAKAVEDLIQEIREEFGALHYLVNNAG--ITGPHQTGIEDYDIDSWRQVIDTNI 119
DVT + LI ++FG ++ L+NNAG I P +++ + N
Sbjct: 64 VVADVTTGAGQDVLIDSTLKKFGKINILINNAGALIVDPEGKTNTSTGVETCLKTFQLNF 123
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP-YTATKHAVIGITQSVA 178
+ P + ++ +VN+S+V P Y+A K A+ +++ A
Sbjct: 124 QSVVEMTQKIRPHL-----ANTHGEIVNVSSVGAGPAAENRFPYYSAAKAALDQYSRNTA 178
Query: 179 LEYAERNVRVNAVAPGYVST 198
++ +RVN V PG+V+T
Sbjct: 179 IDLIPDGIRVNIVQPGFVAT 198
>At5g50770 [Q] KOG1205 Predicted dehydrogenase
Length = 342
Score = 70.1 bits (170), Expect = 3e-12
Identities = 54/193 (27%), Positives = 92/193 (46%), Gaps = 8/193 (4%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS-RVIGKEVD 65
AGK+ ++TGA++G+GE +A RGA + + + A + GS V+ D
Sbjct: 46 AGKVVVITGAASGIGEALAYEYGKRGAYLALVDIRGEPLFHVAALAELYGSPEVLPLVAD 105
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
V+ + E I+ FG L +LV NAG+ P + D+ +D N G+ Y
Sbjct: 106 VSKLQDCERFIRATVLHFGRLDHLVTNAGV-APLYFFADIEDVSKASPAMDINFWGSVYC 164
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+A P ++ +V +++ G + P +S Y A+K AVI +++ E+ +
Sbjct: 165 TFFASPYLKK-----FRGRIVVIASGCGYIASPRLSFYCASKAAVIAFYETLRTEFGS-D 218
Query: 186 VRVNAVAPGYVST 198
+ V VAPG V +
Sbjct: 219 IGVTIVAPGIVDS 231
>7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 361
Score = 70.1 bits (170), Expect = 3e-12
Identities = 56/186 (30%), Positives = 91/186 (48%), Gaps = 17/186 (9%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRG---ATVVITSRHLSEVQETAGNIDPSGS 57
+ E +GK+ALVTG +G+G I L RG A V + S+ E E I
Sbjct: 85 LKEKDVSGKVALVTGGGSGLGREICLELARRGCKLAVVDVNSKGCYETVELLSKIP---- 140
Query: 58 RVIGKEV--DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQT-GIEDYDIDSWRQV 114
R + K DV+ + ++ + ++ +E G + LVNNA + T ++ +ID+ +
Sbjct: 141 RCVAKAYKNDVSSPRELQLMAAKVEKELGPVDILVNNASLMPMTSTPSLKSDEIDT---I 197
Query: 115 IDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGIT 174
+ N+ T K LP M + S +V ++A+ GLV +PG YTATK+ + G
Sbjct: 198 LQLNLGSYIMTTKEFLPKMINRKS----GHLVAVNALAGLVPLPGAGIYTATKYGIEGFM 253
Query: 175 QSVALE 180
+S+ E
Sbjct: 254 ESLRAE 259
>7295622 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 70.1 bits (170), Expect = 3e-12
Identities = 51/198 (25%), Positives = 89/198 (44%), Gaps = 11/198 (5%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPS-GSRVIGKEVDVT 67
++A+VTGAS+G+G +AR L G VV +R + ++ + P R+ DV
Sbjct: 7 RVAVVTGASSGIGAAVARHLVSAGVIVVGLARRVDRMKAIKEQLPPELQGRLHAIHCDVE 66
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
+V I E+ G LVNNAG P Q + +++ +QV++ N+ G +
Sbjct: 67 DLDSVTAAFDWIEEQLGGCDILVNNAGCLNPGQ--LLTLELEQLQQVLNVNLMGVVICTR 124
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLVGIPG-----ISPYTATKHAVIGITQSVALEYA 182
A M+ D ++N ++ PG ++ Y TKH V + + + E
Sbjct: 125 RAFRSMQ-QREVDGHVILINSLTGRNIINPPGDELQVLNMYPLTKHGVTAMLEVLRQELR 183
Query: 183 --ERNVRVNAVAPGYVST 198
+ ++V ++ PG T
Sbjct: 184 GFKTKIKVTSITPGVTDT 201
>CE07539 [Q] KOG1205 Predicted dehydrogenase
Length = 537
Score = 69.7 bits (169), Expect = 4e-12
Identities = 51/198 (25%), Positives = 102/198 (50%), Gaps = 12/198 (6%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVI 60
+S+ + KI ++TGAS+G+G+ +A L+ RGA V++ +R +++E + + + +
Sbjct: 71 LSKLNVKNKIVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICAEL--TKTFPL 128
Query: 61 GKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNIN 120
K + + + + + L+NNAG++ ++ +D + R+ ++TN+
Sbjct: 129 NKNKPTYYFFDITNPDKAPWAQIPKVDVLINNAGMS--NRGSCQDTTMAIHRKAMETNLF 186
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
G + L S SPD +V S++ G V IP Y+A+KHA+ G + E
Sbjct: 187 GHVQVTQSLL----SKLSPD--GCIVVTSSIQGKVAIPYRGSYSASKHALQGYFDCLRAE 240
Query: 181 YAERNVRVNAVAPGYVST 198
+ +N+ + V+ GY++T
Sbjct: 241 H--KNLHILVVSAGYINT 256
>Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 312
Score = 69.3 bits (168), Expect = 5e-12
Identities = 67/238 (28%), Positives = 120/238 (50%), Gaps = 13/238 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
G+ A+VTG++ G+G+ A L G VV+ SR ++ + + I +V + + V
Sbjct: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEK-FKVETRTIAVD 108
Query: 68 VAKAVEDLIQEIREEFGALHY--LVNNAGITGPHQTGIEDY-DIDSW-RQVIDTNINGTF 123
A ED+ +I+ L LVNN G++ + D D+D+ +++I+ NI
Sbjct: 109 FAS--EDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVC 166
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
+ LP M S + A++N+S+ +G++ +P ++ Y+ATK V +Q + EY
Sbjct: 167 KMTQLVLPGMVERS----KGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS 222
Query: 184 RNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMK-RMATMTEVSNTVLFLLSPLTG 240
+ V V +V P +V+T K+ + K T S + +K + T+ S T +L+ L G
Sbjct: 223 KGVFVQSVLPYFVAT-KLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLIHALMG 279
>Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 332
Score = 69.3 bits (168), Expect = 5e-12
Identities = 49/197 (24%), Positives = 100/197 (49%), Gaps = 11/197 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSR----VIGKE 63
G +VTG S+G+G+ IA + +GA + + +R+ ++ + I+ V+
Sbjct: 32 GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCIS 91
Query: 64 VDVTVA-KAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
VDV+ VE++I++ +E+ G + LVN AG+ + ED ++ ++ +++ N G+
Sbjct: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGK--FEDLEVSTFERLMSINYLGS 149
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
Y + + M+ +V +S+ G +G+ G + Y+A+K A+ G+ +++ +E
Sbjct: 150 VYPSRAVITTMKERRV----GRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVK 205
Query: 183 ERNVRVNAVAPGYVSTP 199
NV + P TP
Sbjct: 206 PYNVYITVAYPPDTDTP 222
>7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 321
Score = 69.3 bits (168), Expect = 5e-12
Identities = 51/198 (25%), Positives = 98/198 (48%), Gaps = 10/198 (5%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-DPSGSRVIGKE 63
S AG++A+VTGA G+G I+ L +G + + ++S ++T I D R +
Sbjct: 49 SIAGEVAVVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDIYKVRAKAYK 108
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
+VT + +L ++ EE G + LVNNAG+ + + D + +I+ N+ F
Sbjct: 109 ANVTNYDDLVELNSKVVEEMGPVTVLVNNAGVM--MHRNMFNPDPADVQLMINVNLTSHF 166
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY-- 181
+T LP M+ + +V +S++ G+ +P + YT TK + +++ +E
Sbjct: 167 WTKLVFLPKMKEL----RKGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELDL 222
Query: 182 -AERNVRVNAVAPGYVST 198
++++ V V P ++ T
Sbjct: 223 ENQKDIHVTTVLPSFLRT 240
>CE28758 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 253
Score = 68.9 bits (167), Expect = 6e-12
Identities = 61/254 (24%), Positives = 116/254 (45%), Gaps = 21/254 (8%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVAK 70
ALV GA++ +G+ + R L G V + + V + A + G V +DV A+
Sbjct: 4 ALVIGATSTLGKAVVRRLAFTGYKVAAAADCPNSVGKVAEDNIKVGGDVTAFSLDVANAE 63
Query: 71 AVEDLIQEIREEFGALHYLV----NNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
++LI ++ E+ G L L+ N + +T ED+D ++ N+ F
Sbjct: 64 HRKELITKVAEKLGGLDTLIIVPPQNEVLGEIIETSGEDFD-----KLFANNLTTPFRLS 118
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
+ A+ + S + +++ L++ G + Y+ +V+ +T+SVA A++ V
Sbjct: 119 QAAMSTLAKSQN----GSIIYLTSCFGFTPSIDMGLYSVASSSVLSLTKSVAQSAAKQGV 174
Query: 187 RVNAVAPGYVSTPKIQAL--------PKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPL 238
RVN+V G + A+ ++ +Q + S P+ R+ ++V++ V FL S
Sbjct: 175 RVNSVVSGMIEGDGTGAVWDHASGEEARQIKQHLESMIPLGRLGRPSDVASYVEFLASTK 234
Query: 239 TGFTTGSVYPIDGG 252
+ TG + GG
Sbjct: 235 ARYITGENCIVGGG 248
>7304181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 331
Score = 68.6 bits (166), Expect = 8e-12
Identities = 55/212 (25%), Positives = 95/212 (43%), Gaps = 18/212 (8%)
Query: 3 EYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVI 60
E + GK+ +VTGA+TG+G+ R + RG TV + R+L + +E I + V
Sbjct: 40 ETNETGKVFIVTGANTGIGKETVREIAKRGGTVYMACRNLKKCEEAREEIVLETKNKYVY 99
Query: 61 GKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITG-PHQTGIEDYDIDSWRQVIDTNI 119
++ D+ +++ + + E LH L+NNAG+ P + ++ + N
Sbjct: 100 CRQCDLASQESIRHFVAAFKREQEHLHVLINNAGVMRCPRSLTSDGIELQ-----LGVNH 154
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGIS---------PYTATKHAV 170
G F L L++ SSP V +L+ G + ++ Y+ +K A
Sbjct: 155 MGHFLLTNLLLDLLK-KSSPSRIVNVSSLAHTRGEINTGDLNSDKSYDEGKAYSQSKLAN 213
Query: 171 IGITQSVALEYAERNVRVNAVAPGYVSTPKIQ 202
+ T+ +A NV NA+ PG V T I+
Sbjct: 214 VLFTRELAKRLEGTNVTANALHPGVVDTEIIR 245
>7290988 [Q] KOG1205 Predicted dehydrogenase
Length = 249
Score = 68.6 bits (166), Expect = 8e-12
Identities = 60/241 (24%), Positives = 110/241 (44%), Gaps = 30/241 (12%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNID-PSGSRVIGKEVDVT 67
++A+++GAS+G+G AR L G VV +R +++ ++ R + DV+
Sbjct: 7 RVAVISGASSGIGAACARLLVAAGLQVVGLARRTDRLEQLRQSLPAEQRMRFHQHKCDVS 66
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGIT-GPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
V+ + I +E G + L+NNAGI G + DI++ ++ TN+ G+ Y
Sbjct: 67 QELQVDTAFEWIEKELGGIDVLINNAGIVLGGQLIDMPTKDINN---ILQTNLMGSIYCT 123
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP---------YTATKHAVIGITQSV 177
K A +SS +L VN G+ G P YT +K A+ + +
Sbjct: 124 KLA------ASSMRRRQVAGHLIFVNSTAGVAGYKPDPADESLNAYTPSKFALTAVQEIC 177
Query: 178 ALEYAER--NVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLL 235
E + ++ ++ PG+V+T + +P ET+ + + + +V+ VL+ L
Sbjct: 178 RQELINQGSKIKTTSINPGWVAT---EIVPDETKAKLG-----EVILQADDVAQAVLYAL 229
Query: 236 S 236
S
Sbjct: 230 S 230
>Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 300
Score = 67.8 bits (164), Expect = 1e-11
Identities = 55/243 (22%), Positives = 109/243 (44%), Gaps = 11/243 (4%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV 64
S G+I L+TGA G+G A + +V+ + ++ETA G++V V
Sbjct: 33 SVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVV 92
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQT-GIEDYDIDSWRQVIDTNINGTF 123
D + + + ++++ E G + LVNNAG+ +D I+ + + N+ F
Sbjct: 93 DCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIE---KTFEVNVLAHF 149
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
+T K LP M + ++ +V +++ G V +P + Y ++K A +G +++ E A
Sbjct: 150 WTTKAFLPAM----TKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAA 205
Query: 184 ---RNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTG 240
V+ + P +V+T I+ + + + R+ ++F+ S +
Sbjct: 206 LQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAF 265
Query: 241 FTT 243
TT
Sbjct: 266 LTT 268
>Hs20373187 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 231
Score = 67.8 bits (164), Expect = 1e-11
Identities = 53/192 (27%), Positives = 92/192 (47%), Gaps = 12/192 (6%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG-SRVIGKEVD 65
AG+I L+TGA +G+G +A G+ +V+ + +ET +G +RV D
Sbjct: 39 AGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCD 98
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGI-TGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
+ + V + ++++E G + L+NNAGI TG D + + D N +
Sbjct: 99 CSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPD---ELMEKSFDVNFKAHLW 155
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE---Y 181
T K LP M + + +V +S+ GL G+ G++ Y A+K A G +SV +E
Sbjct: 156 TYKAFLPAMIA----NDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQ 211
Query: 182 AERNVRVNAVAP 193
++ ++ V P
Sbjct: 212 KQKGIKTTIVCP 223
>CE11498 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 323
Score = 67.8 bits (164), Expect = 1e-11
Identities = 63/206 (30%), Positives = 93/206 (44%), Gaps = 21/206 (10%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRH----------LSEVQETAGNIDPSGSR 58
++ALVTGAS G+G GIA L GATV IT R L + A I G +
Sbjct: 8 QVALVTGASRGIGRGIALQLGEAGATVYITGRRPELSDNFRLGLPSLDYVAKEITSRGGK 67
Query: 59 VIGKEVDVTVAKAVEDLIQEIRE-EFGALHYLVNNAGITGPHQTGI-----EDYDIDSWR 112
I VD + V+ L ++I+E E G L LVNN + T + D D W
Sbjct: 68 GIALYVDHSNMTEVKFLFEKIKEDEEGKLDILVNNVYNSLGKATEMIGKTFFDQDPSFWD 127
Query: 113 QVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIG 172
+ + +Y YA +M + +VN+ ++ GL + ++ Y A K A+
Sbjct: 128 DINGVGLRNHYYCSVYAARMMVER----RKGLIVNVGSLGGLKYVFNVA-YGAGKEALAR 182
Query: 173 ITQSVALEYAERNVRVNAVAPGYVST 198
++ +A+E NV V + PG V T
Sbjct: 183 MSTDMAVELNPYNVCVVTLIPGPVKT 208
>At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 331
Score = 67.4 bits (163), Expect = 2e-11
Identities = 57/212 (26%), Positives = 98/212 (45%), Gaps = 12/212 (5%)
Query: 13 VTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNID-PSGSRVIGKEVDVTVAKA 71
+TG S+G+G +A GA V I +R ++ E +I +G V DV A
Sbjct: 42 ITGGSSGIGLALAHRAVSEGAKVSILARSTEKLAEAKRSIQLATGVEVATFSADVRDYDA 101
Query: 72 VEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKYALP 131
V I +E G + L+ N G+ + +E + + +ID N+ G+F +K ALP
Sbjct: 102 VSKAI----DESGPIDVLIVNQGVFIGKE--LEKQSPEEVKFMIDVNLTGSFNVIKAALP 155
Query: 132 LMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRVNAV 191
M++ A++ +S+ G GI G + Y+A+K + G+ Q++ E + V +
Sbjct: 156 AMKAREGR-GPASISLVSSQAGQAGIYGYTAYSASKFGLQGLAQALQQEVISDGIHVTLL 214
Query: 192 APGYVSTP----KIQALPKETQQWMSSQHPMK 219
P TP +++ P+ T +S MK
Sbjct: 215 FPPDTDTPGFEQELKKRPELTSIIAASSGSMK 246
>7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 278
Score = 67.4 bits (163), Expect = 2e-11
Identities = 71/256 (27%), Positives = 115/256 (44%), Gaps = 18/256 (7%)
Query: 2 SEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQE--TAGNIDPSGSRV 59
++ SF GK A+VTG + G+G +++ L GA V ++E P+ S +
Sbjct: 16 TKMSFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVM 75
Query: 60 IGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNI 119
I K +DV K VE +EI + FG + +VN AGI D D+ ++ + N+
Sbjct: 76 IIK-MDVANKKGVEATYEEIAKTFGNIDIVVNVAGI-------FNDKDV---QRTLLVNL 124
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVAL 179
G + ALP M + VVN+S+V GL + I Y ATK +I T+ +A
Sbjct: 125 GGIINSTLSALPYM-GKDNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLAN 183
Query: 180 E--YAERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVS--NTVLFLL 235
E Y ++ V PG T ++ +S + + + + S + +L
Sbjct: 184 EKYYQRSGIKFVTVCPGATMTDMFTNFTEKIIFPETSDETYRILDRLNKQSAADVSRCIL 243
Query: 236 SPLTGFTTGSVYPIDG 251
+ L G+VY I+G
Sbjct: 244 NVLEKDKNGAVYVIEG 259
>CE02490_1 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 302
Score = 67.0 bits (162), Expect = 2e-11
Identities = 55/201 (27%), Positives = 96/201 (47%), Gaps = 23/201 (11%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLS-------EVQETAGNIDPSGSR 58
F G+ L+TGAS G+G+ IA L GA +V+ ++ + + A I+ +G +
Sbjct: 7 FVGRTVLITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYSAAEEIEKAGGK 66
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNA---GITGPHQTGIEDYDIDSWRQVI 115
+ VDV +V+ ++E ++FG + L+NNA +T T ++ YD+ +
Sbjct: 67 ALPCIVDVRDEASVKASVEEAVKKFGGIDILINNASAISLTDTENTEMKRYDL-----MH 121
Query: 116 DTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQ 175
N GTF K LP ++S +P V+N+S L+ + + A A G++
Sbjct: 122 SINTRGTFLMTKTCLPYLKSGKNPH----VLNISPPL-LMETRWFANHVAYTMAKYGMSM 176
Query: 176 SVALEYAE---RNVRVNAVAP 193
V ++ E + VNA+ P
Sbjct: 177 CVLGQHEEFRPHGIAVNALWP 197
>Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 343
Score = 66.6 bits (161), Expect = 3e-11
Identities = 58/211 (27%), Positives = 99/211 (46%), Gaps = 19/211 (9%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGS-RVIGKEVDVT 67
K LVTG +G G +A+ L +G V + + +D S R+ +++V
Sbjct: 56 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
Query: 68 VAKAVEDLIQEIREEFG----ALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
++ VE +++ +R + LVNNAGI+ + +E +++++QV + N+ GT
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGE--VEFTSLETYKQVAEVNLWGTV 173
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
K LPL+ + + VVN+S++ G + P SPY TK V + + E
Sbjct: 174 RMTKSFLPLIRRA-----KGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYP 228
Query: 184 RNVRVNAVAPG-------YVSTPKIQALPKE 207
V+V+ V PG S IQA+ K+
Sbjct: 229 LGVKVSVVEPGNFIAATSLYSPESIQAIAKK 259
>At5g51030 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 314
Score = 66.6 bits (161), Expect = 3e-11
Identities = 42/141 (29%), Positives = 75/141 (52%), Gaps = 6/141 (4%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVA 69
+A+VTGA+ G+G + R L G TV++TSR + E A + G V +D+ +
Sbjct: 39 VAVVTGANRGIGFEMVRQLAGHGLTVILTSRDENVGVEAAKILQEGGFNVDFHRLDILDS 98
Query: 70 KAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKYA 129
++++ + I+E++G + L+NNAG+ + G D ++ VI TN GT +
Sbjct: 99 SSIQEFCEWIKEKYGFIDVLINNAGVN--YNVG-SDNSVEFSHMVISTNYYGTKNIINAM 155
Query: 130 LPLMESSSSPDSEAAVVNLSA 150
+PLM + A +VN+++
Sbjct: 156 IPLMRHAC---QGARIVNVTS 173
>7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 325
Score = 66.6 bits (161), Expect = 3e-11
Identities = 54/220 (24%), Positives = 100/220 (44%), Gaps = 12/220 (5%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG-SRVIGKEVD 65
+G++ L+TG GVG IA A +VI + ++ T + G G VD
Sbjct: 55 SGQVVLITGGGGGVGRLIALNFARLQARIVIWDINQEAIKTTVDLLAKHGYDNCKGYVVD 114
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTG-IEDYDIDSWRQVIDTNINGTFY 124
++ + + ++ EE G + L+NNAGI + D I + + NI ++
Sbjct: 115 ISDREQIYQRASQVTEEVGPVDILINNAGIVCCKPFWELHDRVIQNTYNI---NIISHYW 171
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE---Y 181
T+K LP M ++ +V + +V G++G G S Y ATK+A IG +S+ + +
Sbjct: 172 TVKAFLPHMMRNN----RGHIVTVGSVTGMLGTYGCSDYAATKYACIGFHESLLTDLKAH 227
Query: 182 AERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRM 221
++++ + P Y++T + + Q+ R+
Sbjct: 228 GYDQIQMSLICPYYINTGMFSGVRPRMMPMLEPQYVADRI 267
>CE05427 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 293
Score = 66.2 bits (160), Expect = 4e-11
Identities = 53/198 (26%), Positives = 87/198 (43%), Gaps = 17/198 (8%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLS-------EVQETAGNIDPSGSR 58
FAGK +TGAS G+G+ IA L GA +V+ ++ + + A I+ +G
Sbjct: 11 FAGKTVFITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYTAAAEIEKAGGH 70
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTN 118
+ VDV AV+ + ++FG + L+NNA T ED D+ + + N
Sbjct: 71 ALPCVVDVRDEAAVKAAVDAAVKKFGGIDILINNASAIS--LTNTEDTDMKRYDLMHSIN 128
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA 178
GT+ K LP ++ +P V+N+S + P+ A G++ V
Sbjct: 129 TRGTYLLTKTCLPYLKKGKNPH----VLNISPPLDMEA-KWFGPHVGYTMAKFGMSMCVL 183
Query: 179 ---LEYAERNVRVNAVAP 193
E+ + VNA+ P
Sbjct: 184 GHHEEFRPYGIAVNALWP 201
>At5g04900 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 341
Score = 66.2 bits (160), Expect = 4e-11
Identities = 53/193 (27%), Positives = 91/193 (46%), Gaps = 10/193 (5%)
Query: 12 LVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-DPSGSRVIGKEVDVTVAK 70
L+TG++ G+G +AR G VVI SR V+ ++ + G V G + DVT K
Sbjct: 83 LITGSTKGIGYALAREFLKAGDNVVICSRSAERVETAVQSLKEEFGEHVWGTKCDVTEGK 142
Query: 71 AVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKYAL 130
V +L+ ++ + +NNAG + + + +V+ TN G + A+
Sbjct: 143 DVRELVAYSQKNLKYIDIWINNAGSNAYSFKPLAEASDEDLIEVVKTNTLGLMLCCREAM 202
Query: 131 PLMESSSSPDSEAAVVNLSAVNGLVG--IPGISPYTATKHAVIGITQSVALEYA---ERN 185
+M + S + N+ G G P + Y ATK +V+ +T+S+ E +N
Sbjct: 203 NMMLTQS---RGGHIFNIDGA-GSDGRPTPRFAAYGATKRSVVHLTKSLQAELQMQDVKN 258
Query: 186 VRVNAVAPGYVST 198
V V+ ++PG V+T
Sbjct: 259 VVVHNLSPGMVTT 271
>Hs4759084 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 302
Score = 65.1 bits (157), Expect = 9e-11
Identities = 56/195 (28%), Positives = 85/195 (42%), Gaps = 8/195 (4%)
Query: 12 LVTGASTGVGEGIARALFVRGA-TVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVAK 70
L+TG G+G +AR RGA +V+ R ++ET I G+ DV +
Sbjct: 42 LITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNRE 101
Query: 71 AVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKYAL 130
V + +RE+ G + LVNNA + H + D D D+ + N G F+T K L
Sbjct: 102 EVYQTAKAVREKVGDITILVNNAAVV--HGKSLMDSDDDALLKSQHINTLGQFWTTKAFL 159
Query: 131 PLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE-RNVRVN 189
P M + +V L++V L IPG Y +K + +S+ L + V
Sbjct: 160 PRMLELQN----GHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSAT 215
Query: 190 AVAPGYVSTPKIQAL 204
V P + ST Q +
Sbjct: 216 TVLPFHTSTEMFQGM 230
>7304177 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 300
Score = 65.1 bits (157), Expect = 9e-11
Identities = 50/228 (21%), Positives = 103/228 (44%), Gaps = 29/228 (12%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVD 65
GK+ +VTGA+TG+G+ + RG TV + R ++ ++ +I + + + +E+D
Sbjct: 14 GKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQNIFSRELD 73
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
++ +++ ++E LH L+NNAG+ +T + D + + N G F
Sbjct: 74 LSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTK----DGFEMQLGVNHMGHFLL 129
Query: 126 LKYALPLMESSSSPDSEAAVVNLSA------------VNGLVGIPGISPYTATKHAVIGI 173
L +++ + + + +VN+S+ +N I Y+ +K A +
Sbjct: 130 THLLLDVLKKT----APSRIVNVSSLVHTQGFIKTADLNSEKSYSRIGAYSQSKLANVLF 185
Query: 174 TQSVALEYAERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRM 221
T+ +A V N++ PG V T + ++ W +HP ++
Sbjct: 186 TRELAKRLEGTGVTTNSLHPGAVDT-------ELSRNWKFLKHPFAQL 226
>CE13054 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 240
Score = 64.7 bits (156), Expect = 1e-10
Identities = 49/164 (29%), Positives = 80/164 (47%), Gaps = 12/164 (7%)
Query: 40 RHLSEVQETAGNIDPSGSRVIGKE--VDVTVAKAVEDLIQEIREEFGALHYLVNNAGI-T 96
R + +T N S V+ K VD++ K + ++ E G + LVNNAGI T
Sbjct: 2 RKSTNSNDTLNNARSSFRSVVAKAYTVDLSEYKEINRTADLVKSEVGKVDILVNNAGIVT 61
Query: 97 GPHQTGIEDYDIDSWRQVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVG 156
G D + + + N N F+T K LP M S ++ +V ++++ G G
Sbjct: 62 GKKLLQCPD---ELMVKTVSVNTNALFFTTKNFLPGMLES----NKGHIVTIASMAGKCG 114
Query: 157 IPGISPYTATKHAVIGITQSVALE-YA-ERNVRVNAVAPGYVST 198
+ G+ Y A+KH +G S+A E YA +++V+ V P Y++T
Sbjct: 115 VAGLVDYCASKHGAVGFNDSLASELYALKKDVKTTVVCPIYINT 158
>7302393 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 355
Score = 64.7 bits (156), Expect = 1e-10
Identities = 56/214 (26%), Positives = 94/214 (43%), Gaps = 25/214 (11%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAG----NIDPSGSRV 59
Y +IA++TG + G+G I L TVV+ R ++ ETA +++ + ++
Sbjct: 63 YKQPDRIAVITGGNRGIGLRIVEKLLACDMTVVMGVRD-PKIAETAVASIVDLNATKGKL 121
Query: 60 IGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGIT-GPHQTGIEDYDIDSWRQVIDTN 118
I +++DV K+V+ Q I+E + + L+NNAGI P + + Y+ N
Sbjct: 122 ICEQLDVGDLKSVKAFAQLIKERYSKVDLLLNNAGIMFAPFKLTADGYE-----SHFAIN 176
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQS-- 176
G F LP + ++ + +VN+S+ L+G TKH G S
Sbjct: 177 FLGHFLLTHLLLPQLRAAGKEGRNSRIVNVSSCVNLIGRINYKDINGTKHYYPGTAYSQS 236
Query: 177 ------------VALEYAERNVRVNAVAPGYVST 198
L+ + +V+VN V PG V T
Sbjct: 237 KLAQILFTRHLQTLLDAEKSHVQVNVVHPGIVDT 270
>7304176 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 280
Score = 64.3 bits (155), Expect = 2e-10
Identities = 46/193 (23%), Positives = 90/193 (45%), Gaps = 19/193 (9%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVD 65
GK+ +VTGA+TG+G+ A + RG TV + R ++ ++ +I + + + +E+D
Sbjct: 14 GKVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARKDIIKETNNQNIFSRELD 73
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
++ ++ + ++E LH L+NNAG+ +T + D + + N G F
Sbjct: 74 LSSLDSIRKFVDGFKKEQPKLHVLINNAGVMRCPKTLTK----DGYELQLGVNHIGHFLL 129
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
L +++++ ++ L+ Y+ +K A + T+ +A
Sbjct: 130 TNLLLDVLKATDLNSEKSYDEGLA-------------YSQSKLANVLFTRELAKRLEGSG 176
Query: 186 VRVNAVAPGYVST 198
V VNA+ PG V T
Sbjct: 177 VTVNALHPGVVDT 189
>Hs5031765 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 63.9 bits (154), Expect = 2e-10
Identities = 61/216 (28%), Positives = 98/216 (45%), Gaps = 26/216 (12%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSR----VIGKE 63
GK +VTGAS G+G +A L GA VV+T+R +Q+ + G+ + G
Sbjct: 34 GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
D+T A E + + + G L L+ N IT D DI R+ ++ N
Sbjct: 94 EDMTFA---EQFVAQAGKLMGGLDMLILN-HITNTSLNLFHD-DIHHVRKSMEVNFLSYV 148
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY-- 181
ALP+++ S+ ++V +S++ G V P ++ Y+A+K A+ G S+ EY
Sbjct: 149 VLTVAALPMLKQSN-----GSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSV 203
Query: 182 AERNVRVNAVAPGYVSTP----------KIQALPKE 207
+ NV + G + T +QA PKE
Sbjct: 204 SRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKE 239
>Hs18582884 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/211 (29%), Positives = 99/211 (46%), Gaps = 26/211 (12%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVD 65
GK+ ++TGA+TG+G+ AR L RGA V I R + + + A I D S+V+ +++D
Sbjct: 39 GKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLD 98
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGI-TGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
++ K++ + E LH L+NNAG+ P+ D + + N G F
Sbjct: 99 LSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSK-----TADGFETHLGVNHLGHF- 152
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVG-IP------------GISPYTATKHAVI 171
L Y L S+P A VVN+S+V +G IP G + Y +K A +
Sbjct: 153 LLTYLLLERLKVSAP---ARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFA-YCHSKLANV 208
Query: 172 GITQSVALEYAERNVRVNAVAPGYVSTPKIQ 202
T+ +A V AV PG V + ++
Sbjct: 209 LFTRELAKRLQGTGVTTYAVHPGVVRSELVR 239
>At1g01800 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 309
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/240 (26%), Positives = 104/240 (43%), Gaps = 47/240 (19%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRH----LSEVQETAGNIDPSGSRV 59
+ F ++A+VTG++ G+G I R L G TVV+T+R L+ VQ+ S +
Sbjct: 30 FLFVSRVAVVTGSNKGIGFEICRQLANNGITVVLTARDENKGLAAVQKLKTENGFSDQAI 89
Query: 60 IGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQT--GIEDYDIDSWRQVIDT 117
+DV+ + L ++ FG L LVNNAG+ G + ++ + + + T
Sbjct: 90 SFHPLDVSNPDTIASLAAFVKTRFGKLDILVNNAGVGGANVNVDVLKAQIAEIVEECVKT 149
Query: 118 NINGTFYTLKYALPLMESSSSP---------------DSEAAVVNLSAVNGLV------- 155
N G + +PL++SS SP +E A LS L
Sbjct: 150 NYYGVKRMCEAMIPLLQSSDSPRIVSIASTMGKLENVSNEWAKGVLSDAENLTEEKIDEV 209
Query: 156 ----------------GIPGI-SPYTATKHAVIGITQSVALEYAERNVRVNAVAPGYVST 198
G P + S Y +K AVI +T+ +A + ++ +N+V PG+V+T
Sbjct: 210 INEYLKDYKEGALQVKGWPTVMSGYILSKAAVIALTRVLAKRH--KSFIINSVCPGFVNT 267
>YIR035c [Q] KOG1204 Predicted dehydrogenase
Length = 254
Score = 63.5 bits (153), Expect = 3e-10
Identities = 64/249 (25%), Positives = 106/249 (41%), Gaps = 10/249 (4%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
GK+ LVTG S G+G+ I LF V+ SE + G R D+T
Sbjct: 2 GKVILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEAPLKKLK-EKYGDRFFYVVGDIT 60
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
++ L+ + G + LV NAG+ P Q + + D+++W+++ D N +
Sbjct: 61 EDSVLKQLVNAAVKGHGKIDSLVANAGVLEPVQ-NVNEIDVNAWKKLYDINFFSIVSLVG 119
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVR 187
ALP ++ + + V+ A N G Y ++K A+ ++A E ER V+
Sbjct: 120 IALPELKKT---NGNVVFVSSDACNMYFSSWG--AYGSSKAALNHFAMTLANE--ERQVK 172
Query: 188 VNAVAPGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTGSVY 247
AVAPG V T + + S +K + E +N +L P T + +++
Sbjct: 173 AIAVAPGIVDTDMQVNIRENVGPSSMSAEQLKMFRGLKE-NNQLLDSSVPATVYAKLALH 231
Query: 248 PIDGGFLAQ 256
I G Q
Sbjct: 232 GIPDGVNGQ 240
>Hs7657478 [Q] KOG1205 Predicted dehydrogenase
Length = 311
Score = 63.2 bits (152), Expect = 4e-10
Identities = 59/199 (29%), Positives = 97/199 (48%), Gaps = 19/199 (9%)
Query: 7 AGKIALVTGASTGVGEGIARALF---VRGATVVITSRHLS--EVQETAGNIDPSGSRVIG 61
A + L++G S+G+G +A L + VV T R L E E A + G +
Sbjct: 4 APRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAG-EALGQTLTV 62
Query: 62 KEVDVTVAKAVEDLIQEIREEFGALHYLVNNAG--ITGPHQTGIEDYDIDSWRQVIDTNI 119
++DV ++V + I+ G + LVNNAG + GP +E + + + V DTN
Sbjct: 63 AQLDVCSDESVAQCLSCIQ---GEVDVLVNNAGMGLVGP----LEGLSLAAMQNVFDTNF 115
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVAL 179
G +K LP M+ + +V +S+V GL G+ Y A+K A+ G +S+A+
Sbjct: 116 FGAVRLVKAVLPGMKRRR----QGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAI 171
Query: 180 EYAERNVRVNAVAPGYVST 198
+ + N+ ++ V PG V T
Sbjct: 172 QLLQFNIFISLVEPGPVVT 190
>CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 427
Score = 63.2 bits (152), Expect = 4e-10
Identities = 50/204 (24%), Positives = 92/204 (44%), Gaps = 9/204 (4%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVI 60
+ + S G+ ++TG +G+G +A R A V I + ET I G+
Sbjct: 34 LRQKSVQGQTVIITGGGSGLGRAMALDFAKRKAKVAIIDVNKEGGLETVKTIAAEGNMAK 93
Query: 61 GKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNIN 120
D++ ++ +EI + FG ++ ++ NA I T + + R+ +D NI
Sbjct: 94 FWYCDISDVDNMKKTAKEIEDTFGDVNIVICNAAILS--FTSFMEISDELLRKCLDVNIF 151
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
GT T++ LP ME+ ++ +V + ++ G G Y +K AV G +S+ +E
Sbjct: 152 GTINTIRAFLPKMETK----NDGHIVCVCSIAGWSGETMGLSYCTSKFAVRGAMESLQME 207
Query: 181 YAER---NVRVNAVAPGYVSTPKI 201
+R ++ + P + TP I
Sbjct: 208 LRDRGLEGIKTTTLYPYFARTPMI 231
>7304178 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 63.2 bits (152), Expect = 4e-10
Identities = 54/212 (25%), Positives = 92/212 (42%), Gaps = 22/212 (10%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVD 65
G++A+VTG + G+G+ L RGATV + R + + + I + + +++D
Sbjct: 14 GRVAIVTGCNQGIGKETVLELARRGATVYMACRDMKKCENARREIIKATNNQNIFARQLD 73
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
+ K++ + + E LH L+NNAGI + E D + I N G F
Sbjct: 74 LCSMKSIRNFAAGFKREQNKLHILINNAGIMDCPKMLTE----DGFEMQIGVNHMGHFLL 129
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAV------------NGLVGIPGISPYTATKHAVIGI 173
L +++SS + + VV LS++ N Y +K A +
Sbjct: 130 TLLLLDVLKSS----APSRVVVLSSIAHRFGRIKRDDLNSEKSYDRKMAYCQSKLANVLF 185
Query: 174 TQSVALEYAERNVRVNAVAPGYVSTPKIQALP 205
T+ +A + V VNA+ PG V+T + P
Sbjct: 186 TRELAKRLSGTGVTVNALHPGVVNTELFRNTP 217
>CE07803 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 323
Score = 62.8 bits (151), Expect = 5e-10
Identities = 59/216 (27%), Positives = 95/216 (43%), Gaps = 31/216 (14%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVIT------SRHLSEVQETAGNIDPS---GSR 58
G LVTG++ G+G A+ LF +GA V++T RH E + + + S R
Sbjct: 3 GLNVLVTGSTCGLGLHTAKILFKKGANVILTCRDEIRGRHAVESLLSGVSQEQSQKEAER 62
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITG-PHQTGIEDYDIDSWRQVIDT 117
+ +DVT ++ + EI F LH ++NNAGI G P + ++ ++ T
Sbjct: 63 IHLFTLDVTNYNSICNFTDEISRMFKYLHVIINNAGIMGMPFELSVDGIEMH-----FAT 117
Query: 118 NINGTFYTLKYALPLMESSSSPD--SEAAVVNLSAVNGLVGIPGIS-------------- 161
N+ G + ++ LPL+ + PD S VV+ IP +S
Sbjct: 118 NVFGHYVVVERLLPLLLKTDRPDFKSRVIVVSSGLYRNAEAIPQVSKLLGQKTYDYSPKQ 177
Query: 162 PYTATKHAVIGITQSVALEYAERNVRVNAVAPGYVS 197
Y +K A T +++ NV V V PG+V+
Sbjct: 178 AYAFSKLANCLYTGALSKMLEPHNVGVYCVRPGFVN 213
>Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 310
Score = 62.4 bits (150), Expect = 6e-10
Identities = 54/194 (27%), Positives = 90/194 (45%), Gaps = 11/194 (5%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
G+ A++TGA G+G+ + L RG VV+ SR L +++ A I+ R G+ V +
Sbjct: 48 GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIE----RTTGRSVKII 103
Query: 68 VAK-AVEDLIQEIREEFGALH--YLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
A +D+ + I+E+ L LVNN G+ D + +I NI
Sbjct: 104 QADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVK 163
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER 184
+ L MES + ++N+S+ L P S Y+A+K V ++++ EY +
Sbjct: 164 MTQLILKHMESR----QKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAK 219
Query: 185 NVRVNAVAPGYVST 198
V + + P VST
Sbjct: 220 EVIIQVLTPYAVST 233
>Hs10190746 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 336
Score = 62.4 bits (150), Expect = 6e-10
Identities = 61/214 (28%), Positives = 90/214 (41%), Gaps = 27/214 (12%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI------------DPS 55
GK L+TGA++G+G A L GA V++ R + +E AG + +P
Sbjct: 43 GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
Query: 56 GSRV---IGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWR 112
S V I +E+D+ ++V QE+ +E L L+NNAGI E D +
Sbjct: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTE----DGFE 158
Query: 113 QVIDTNINGTFYTLKYALPLMESS--------SSPDSEAAVVNLSAVNGLVGIPGISPYT 164
N G F L L++SS SS + +N +N Y+
Sbjct: 159 MQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYS 218
Query: 165 ATKHAVIGITQSVALEYAERNVRVNAVAPGYVST 198
+K A I T+ +A NV VN + PG V T
Sbjct: 219 RSKLANILFTRELARRLEGTNVTVNVLHPGIVRT 252
>Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 309
Score = 62.0 bits (149), Expect = 8e-10
Identities = 49/194 (25%), Positives = 93/194 (47%), Gaps = 12/194 (6%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
G+ A+V+GA+ G+G+ A L RG +++ SR+ ++Q A +I + E D+
Sbjct: 46 GRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDI----ADTYKVETDII 101
Query: 68 VA--KAVEDLIQEIREEF--GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
VA + ++ IRE + LVNN G+ P+ D +I+ NI
Sbjct: 102 VADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAAS 161
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
+ LP M + A+V +S+ + P ++ ++A+K + ++++ EYA
Sbjct: 162 LMVHVVLPGMVER----KKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYAS 217
Query: 184 RNVRVNAVAPGYVS 197
+ + V ++ P YV+
Sbjct: 218 KGIFVQSLIPFYVA 231
>Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 319
Score = 62.0 bits (149), Expect = 8e-10
Identities = 56/208 (26%), Positives = 96/208 (45%), Gaps = 15/208 (7%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K +TG +G G AR +G V+ L+E TA + S R+ +DVT
Sbjct: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAAC--LTESGSTALKAETS-ERLRTVLLDVTD 86
Query: 69 AKAVEDLIQEIREEFG--ALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
+ V+ Q ++ + G L L+NNAG+ G + ++ +R+ I+ N+ G
Sbjct: 87 PENVKRTAQWVKNQVGEKGLWGLINNAGVPGV-LAPTDWLTLEDYREPIEVNLFGLISVT 145
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
LPL++ + + V+N+S+V G + I G YT +K+AV G S+ + V
Sbjct: 146 LNMLPLVKKA-----QGRVINVSSVGGRLAIVG-GGYTPSKYAVEGFNDSLRRDMKAFGV 199
Query: 187 RVNAVAPGYVST---PKIQALPKETQQW 211
V+ + PG T ++ + K+ W
Sbjct: 200 HVSCIEPGLFKTNLADPVKVIEKKLAIW 227
>7301617_1 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 302
Score = 62.0 bits (149), Expect = 8e-10
Identities = 49/197 (24%), Positives = 88/197 (43%), Gaps = 17/197 (8%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRHL-------SEVQETAGNIDPSGSRV 59
AG+ +TGAS G+G+ IA GA +V+ ++ + A I+ +G +
Sbjct: 8 AGRTLFITGASRGIGKEIALKAARDGANIVVAAKTAEPHPKLPGTIYSAAEEIEKAGGKA 67
Query: 60 IGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNI 119
VDV + V ++ +FG + ++NNA T D D+ + + + N
Sbjct: 68 YPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAIS--LTNTPDTDMKRYDLMHNINT 125
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGI---PGISPYTATKHAVIGITQS 176
GTF K LP ++ S + A ++N+S + P ++ YT K+ +
Sbjct: 126 RGTFLVSKVCLPYLKKS----NHAHILNISPPLSMKPKWFGPHVA-YTMAKYGMSMCVLG 180
Query: 177 VALEYAERNVRVNAVAP 193
+A E+ + + VNA+ P
Sbjct: 181 MAAEFKDEGISVNALWP 197
>SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 61.6 bits (148), Expect = 1e-09
Identities = 58/248 (23%), Positives = 104/248 (41%), Gaps = 10/248 (4%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K+ + G + G+G + + L R T V S E S V E+DVT
Sbjct: 6 KVYFIAGGNRGIGLSLVKELSSREGTTVFASARKPEAATELQEWSKSHPNVKTVELDVTS 65
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
++ + Q + + + L N+GI + T +E + + W TN+ G + K
Sbjct: 66 QQSANEAAQSVAKAVDGIDVLWLNSGICQSYYTVMEAPE-EVWNAHYQTNVLGPIHVFKA 124
Query: 129 ALPLMESSSSPDSEAAVVNLSAVNGLVG---IPGISPYTATKHAVIGITQSVALEYAERN 185
PL+ + V+ S+ G +G G S Y +K A+ + +++E A+ +
Sbjct: 125 FYPLLTKKKT----RQVIFTSSECGSMGDFRATGFSAYGQSKAAINFTMKELSVELADEH 180
Query: 186 VRVNAVAPGYVSTP-KIQALPKETQQWMSSQHPMKRMATMTEVS-NTVLFLLSPLTGFTT 243
++ PG V T A+ K T+ +K++ + E S +++L ++ L
Sbjct: 181 FTFISIHPGVVKTDMNADAIKKFTETSPEMLTYLKKVTIIPEESVSSMLKVVDNLKPENN 240
Query: 244 GSVYPIDG 251
GS Y DG
Sbjct: 241 GSFYRYDG 248
>Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 341
Score = 61.2 bits (147), Expect = 1e-09
Identities = 61/230 (26%), Positives = 104/230 (44%), Gaps = 46/230 (20%)
Query: 3 EYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGK 62
E S AG++ L+TGA +G+G A R A +V+ + +ETAG + R I +
Sbjct: 31 EKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMV-----RHIYR 85
Query: 63 EVDVTVAKAV------EDLI------------------------QEIREEFGALHYLVNN 92
+++ A A+ E+++ + +R+E G + LVNN
Sbjct: 86 DLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNN 145
Query: 93 AG-ITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAV 151
AG ++G H D I+ V N + F+T K LP M + +V +++
Sbjct: 146 AGVVSGHHLLECPDELIERTMMV---NCHAHFWTTKAFLPTMLEI----NHGHIVTVASS 198
Query: 152 NGLVGIPGISPYTATKHAVIGITQSVA--LEYAERN-VRVNAVAPGYVST 198
GL G+ Y A+K V+G +S++ L+ AE++ ++ V P V T
Sbjct: 199 LGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDT 248
>CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 347
Score = 60.8 bits (146), Expect = 2e-09
Identities = 51/219 (23%), Positives = 100/219 (45%), Gaps = 17/219 (7%)
Query: 3 EYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI----DPSGSR 58
++ F + A+VTG S G+G +A L RG V I +R++ ++++ ++ D G R
Sbjct: 33 DFHFFRRHAIVTGGSKGIGFQLAVGLIERGCHVTIVARNVKDLEKACADLQVLADQRGQR 92
Query: 59 --VIGKEVDVTVA-KAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVI 115
V K +D+T ++ + E G + L+NNAG + Q + I + + +
Sbjct: 93 QKVHWKSIDMTGGYDVIKSAFDDAARELGPIDILINNAGHS--VQAPFCELPITDFEKQM 150
Query: 116 DTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQ 175
N + + + M++ + + +S+ G I G S Y+ TK A+ G
Sbjct: 151 AVNYLSAVHATRAVVDDMKTRKT----GHISFVSSAAGQFAIFGYSAYSPTKFALRGFAD 206
Query: 176 SVALEYAERNVRVNAVAPGYVSTP----KIQALPKETQQ 210
++ +E V V + P T +++ +P+ET++
Sbjct: 207 TLHMELLPYKVNVGVLYPPNTDTEGFKVELETMPEETKK 245
>7300387 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 60.1 bits (144), Expect = 3e-09
Identities = 47/207 (22%), Positives = 93/207 (44%), Gaps = 13/207 (6%)
Query: 2 SEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRV 59
+E GK ++TGA++G+G+ A+ L RGA +++ R+L I + +++
Sbjct: 27 TETKMEGKTVIITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKETKNNKI 86
Query: 60 IGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNI 119
+ K++D+ K+V + +I + + L++NAG+ + + D + TN
Sbjct: 87 LVKKLDLGSQKSVREFAADIVKTEPKIDVLIHNAGMALAFRGQTSE---DGVELTMATNH 143
Query: 120 NGTFYTLKYALPLMESS--------SSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVI 171
G F + +++ S +S + VNL+ +N + P Y +K A I
Sbjct: 144 YGPFLLTHLLIDVLKKSAPARIVIVASELYRLSSVNLAKLNPIGTFPAAYLYYVSKFANI 203
Query: 172 GITQSVALEYAERNVRVNAVAPGYVST 198
+ +A V VN + PG + +
Sbjct: 204 YFARELAKRLEGTKVTVNFLHPGMIDS 230
>7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 308
Score = 60.1 bits (144), Expect = 3e-09
Identities = 53/193 (27%), Positives = 89/193 (45%), Gaps = 8/193 (4%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV--D 65
G A VTGAS G+G+ A+ L + VV+ +R ++Q A I G+ V K V D
Sbjct: 49 GDWAAVTGASDGIGKEYAKELARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIAD 108
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
T V + I++ + LVNN GI P + Y+ + + +IDTN+
Sbjct: 109 FTKGSQVYEHIEKETANI-PISILVNNVGIATP--KSLLKYNQEETQNIIDTNVVAVSQL 165
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERN 185
+ M++S + A+VN+ + L +P + Y A+K +T ++ E
Sbjct: 166 SRIFFQRMKASK---LKGAIVNVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYG 222
Query: 186 VRVNAVAPGYVST 198
+ V ++P +V T
Sbjct: 223 IHVQMLSPNFVVT 235
>Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 59.7 bits (143), Expect = 4e-09
Identities = 55/216 (25%), Positives = 92/216 (42%), Gaps = 15/216 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K +TG +G G +AR L RG V+ ++ G + R+ +DVT
Sbjct: 30 KYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQ---TSDRLETVTLDVTK 86
Query: 69 AKAVEDLIQEIREEFG--ALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
+++ Q ++E G L LVNNAGI P T E + + ++ N+ G
Sbjct: 87 MESIAAATQWVKEHVGDRGLWGLVNNAGILTP-ITLCEWLNTEDSMNMLKVNLIGVIQVT 145
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
LPL+ + +VN+S++ G V + Y +K+ V + + E V
Sbjct: 146 LSMLPLVRR-----ARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHFGV 199
Query: 187 RVNAVAPGYV---STPKIQALPKETQQWMSSQHPMK 219
+++ V PGY T Q+L + Q W + +K
Sbjct: 200 KISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIK 235
>Hs20070272 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 318
Score = 59.3 bits (142), Expect = 5e-09
Identities = 58/221 (26%), Positives = 100/221 (45%), Gaps = 34/221 (15%)
Query: 2 SEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHL-------SEVQETAGNIDP 54
S GK+ +VTGA+TG+G+ A+ L RGA V + R + E+Q T GN
Sbjct: 35 STVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGN--- 91
Query: 55 SGSRVIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGI-TGPHQTGIEDYDIDSWRQ 113
+V+ +++D++ K++ + E LH L+NNAG+ P+ + +++
Sbjct: 92 --QQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMH---- 145
Query: 114 VIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVG------IPGISPYTA-- 165
I N G F L ++ S + + +VN+S++ +G + G Y A
Sbjct: 146 -IGVNHLGHFLLTHLLLEKLKES----APSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGL 200
Query: 166 ----TKHAVIGITQSVALEYAERNVRVNAVAPGYVSTPKIQ 202
+K A I TQ +A V +V PG V + ++
Sbjct: 201 AYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVR 241
>CE13008 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 247
Score = 59.3 bits (142), Expect = 5e-09
Identities = 48/190 (25%), Positives = 85/190 (44%), Gaps = 13/190 (6%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAG---NIDPSGSRVIGK 62
F+GK +VTG+S+G+G A GA V IT R +++ T + + V
Sbjct: 4 FSGKSVIVTGSSSGIGRATAVLFAKYGAQVTITGRDAGKLEATKKKMLKVMKNPENVCVV 63
Query: 63 EVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
++T + ++++Q + FG + LVNNAG T D + + + N
Sbjct: 64 VANLTDSDGQDEIVQSALDAFGRIDVLVNNAGANVVDGTFNTDQSTELYHKTFQINFEAV 123
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP---YTATKHAVIGITQSVAL 179
+K + +S+ +VN+S+V G ++P Y A+K A+ T+ VAL
Sbjct: 124 IEMVK-----KTKNHLIESKGEIVNVSSV--AAGPQALAPSPYYAASKAALDQYTRCVAL 176
Query: 180 EYAERNVRVN 189
+ + + N
Sbjct: 177 DLILQGIEEN 186
>7297516 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 256
Score = 58.9 bits (141), Expect = 7e-09
Identities = 46/216 (21%), Positives = 101/216 (46%), Gaps = 17/216 (7%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQ--ETAGNIDPSGSRVIG 61
+ + GK + G+ +G+G + L + ++ + V+ + I+PS +V+
Sbjct: 2 FDWTGKNVVYVGSFSGIGWQMMMQLMQKDIKMMGIMHRMENVKMMKKLQAINPS-VKVVF 60
Query: 62 KEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNING 121
++++ ++E ++++ + G + ++N G+ + D D+++ + N+ G
Sbjct: 61 MQMNLMEKMSIEQAMKKMGQMMGHIDVMINGEGV-------LLDKDVET---TMGMNLTG 110
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA--L 179
+ A+P M+ + VVN+S+V GL P S Y A H ++G T+S+ +
Sbjct: 111 MIQSTMMAMPYMDKTQM-GMGGMVVNMSSVYGLEPAPAFSVYAAAMHGILGFTRSMGDKM 169
Query: 180 EYAERNVRVNAVAPGYVSTPKIQALPKETQQWMSSQ 215
Y + V A+ PG ++ I L ++ W S+
Sbjct: 170 IYQKTGVMFMAMCPGLTNSEMIMNL-RDNVTWHHSE 204
>HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 58.5 bits (140), Expect = 9e-09
Identities = 54/192 (28%), Positives = 85/192 (44%), Gaps = 12/192 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K +TG +G G+ +AR L RG V+ ++ G + R+ +DVT
Sbjct: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQ---TSDRLETVTLDVTK 86
Query: 69 AKAVEDLIQEIRE--EFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
++V Q ++E L LVNNAGI+ P E + ++D N+ G
Sbjct: 87 TESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPN-ELLTKQDFVTILDVNLLGVIDVT 145
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
LPL+ + VVN+S+V G V + G Y +K+ V + S+ E + V
Sbjct: 146 LSLLPLVRK-----ARGRVVNVSSVMGRVSLFG-GGYCISKYGVEAFSDSLRRELSYFGV 199
Query: 187 RVNAVAPGYVST 198
+V + PGY T
Sbjct: 200 KVAMIEPGYFKT 211
>At3g61220 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 58.5 bits (140), Expect = 9e-09
Identities = 66/253 (26%), Positives = 103/253 (40%), Gaps = 69/253 (27%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRH----LSEVQETAGNIDPSGSRVIGKEV 64
+ A+VTGA+ G+G I R L G VV+TSR L V+ ++ S ++ ++
Sbjct: 7 RYAVVTGANRGIGFEICRQLASEGIRVVLTSRDENRGLEAVETLKKELEISDQSLLFHQL 66
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITG--------PHQTGIEDYDIDS------ 110
DV ++ L + ++ +FG L LVNNAGI G G E + D
Sbjct: 67 DVADPASITSLAEFVKTQFGKLDILVNNAGIGGIITDAEALRAGAGKEGFKWDEIITETY 126
Query: 111 --WRQVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLV---------GIPG 159
+ I N G + +PL++ S SP +VN+S+ G + GI
Sbjct: 127 ELTEECIKINYYGPKRMCEAFIPLLKLSDSP----RIVNVSSSMGQLKNVLNEWAKGILS 182
Query: 160 ----------------------------------ISPYTATKHAVIGITQSVALEYAERN 185
+S Y +K ++ G T+ +A ++ E
Sbjct: 183 DAENLTEERIDQVINQLLNDFKEGTVKEKNWAKFMSAYVVSKASLNGYTRVLAKKHPE-- 240
Query: 186 VRVNAVAPGYVST 198
RVNAV PG+V T
Sbjct: 241 FRVNAVCPGFVKT 253
>At2g24190 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 58.5 bits (140), Expect = 9e-09
Identities = 61/255 (23%), Positives = 104/255 (39%), Gaps = 73/255 (28%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRH----LSEVQETAGNIDPSGSRVIGKEV 64
+ A+VTG + G+G I R L +G V++TSR L V+ ++ S ++ ++
Sbjct: 7 RYAIVTGGNRGIGFEICRQLANKGIRVILTSRDEKQGLEAVETLKKELEISDQSIVFHQL 66
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGP------------------HQTGIEDY 106
DV+ +V L + ++ FG L L+NNAG+ G +T E Y
Sbjct: 67 DVSDPVSVTSLAEFVKTHFGKLDILINNAGVGGVITDVDALRAGTGKEGFKWEETITETY 126
Query: 107 DIDSWRQVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLV---------GI 157
++ + I N G + +PL++ S SP ++N+S+ G V GI
Sbjct: 127 ELA--EECIKINYYGPKRMCEAFIPLLQLSDSP----RIINVSSFMGQVKNLVNEWAKGI 180
Query: 158 PG----------------------------------ISPYTATKHAVIGITQSVALEYAE 183
+S Y +K + T+ +A ++ E
Sbjct: 181 LSDAENLTEVRIDQVINQLLNDLKEDTAKTKYWAKVMSAYVVSKAGLNAYTRILAKKHPE 240
Query: 184 RNVRVNAVAPGYVST 198
+RVN+V PG+V T
Sbjct: 241 --IRVNSVCPGFVKT 253
>SPAC977.08 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 58.2 bits (139), Expect = 1e-08
Identities = 33/140 (23%), Positives = 70/140 (49%), Gaps = 6/140 (4%)
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTN 118
V+ ++DV +++ +++ FG + L+NNAG + + +E + + +TN
Sbjct: 16 VLVTQLDVNNFSSIKKSVEKAISHFGRIDVLLNNAGYSV--YSPLESTTEEQIHNIFNTN 73
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA 178
+ G +K P+ S + ++N+S++ G + P Y TK+A+ GI++++
Sbjct: 74 VFGALEVIKAITPIFRSQHN----GMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALT 129
Query: 179 LEYAERNVRVNAVAPGYVST 198
E V+V + PG+ +T
Sbjct: 130 WEMQSIGVKVKIIEPGFTAT 149
>SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 58.2 bits (139), Expect = 1e-08
Identities = 33/140 (23%), Positives = 70/140 (49%), Gaps = 6/140 (4%)
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTN 118
V+ ++DV +++ +++ FG + L+NNAG + + +E + + +TN
Sbjct: 16 VLVTQLDVNNFSSIKKSVEKAISHFGRIDVLLNNAGYSV--YSPLESTTEEQIHNIFNTN 73
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA 178
+ G +K P+ S + ++N+S++ G + P Y TK+A+ GI++++
Sbjct: 74 VFGALEVIKAITPIFRSQHN----GMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALT 129
Query: 179 LEYAERNVRVNAVAPGYVST 198
E V+V + PG+ +T
Sbjct: 130 WEMQSIGVKVKIIEPGFTAT 149
>YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 308
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/196 (22%), Positives = 96/196 (48%), Gaps = 20/196 (10%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVAK 70
AL+TG S+G+G +A+ L R V++ +++Q + + + D+T
Sbjct: 41 ALITGGSSGLGFELAKELSRRINKVIV-----ADIQSFPTFAQVEYNNIFYYQCDITSLD 95
Query: 71 AVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK-YA 129
+++L + I + G ++ ++NNAG+ H +E Q+ID N+ G + + +A
Sbjct: 96 EIKNLKKAIERDHGNINIIINNAGVA--HIKKLEHMTNKEVEQLIDINLIGAYRIISTFA 153
Query: 130 LPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGI-------TQSVALEYA 182
+++ + E ++N+++V G + ++ Y A+K A+IG +S++ E
Sbjct: 154 EDMID-----NREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLSTECN 208
Query: 183 ERNVRVNAVAPGYVST 198
+ ++ V PG + T
Sbjct: 209 KTGIKTLLVCPGKIKT 224
>YKL055c [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 57.0 bits (136), Expect = 3e-08
Identities = 67/275 (24%), Positives = 118/275 (42%), Gaps = 56/275 (20%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVA 69
+A+VTGA+ G+G+ I + LF +G + +I ++ TA ID G G A
Sbjct: 6 VAIVTGATRGIGKAICQKLFQKGLSCIILGSTKESIERTA--ID-RGQLQSGLSYQRQCA 62
Query: 70 KAVE-------------DLIQ------EIREEFGAL----------------HYLVNNAG 94
A++ D I+ +++++ L + L+N AG
Sbjct: 63 IAIDFKKWPHWLDYESYDGIEYFKDRPPLKQKYSTLFDPCNKWSNNERRYYVNLLINCAG 122
Query: 95 ITGPH------QTGIEDY-DIDSWRQVIDTNINGTFYTLKYALPLME---SSSSPDSEAA 144
+T + I+D +++ V TNI +KY + S +
Sbjct: 123 LTQESLSVRTTASQIQDIMNVNFMSPVTMTNI-----CIKYMMKSQRRWPELSGQSARPT 177
Query: 145 VVNLSAV--NGLVGIPGISPYTATKHAVIGITQSVALEYAERNVRVNAVAPGYV-STPKI 201
+VN+S++ +G + +PG S Y+A+K A+ T+ +A E RN+R ++PG V T I
Sbjct: 178 IVNISSILHSGKMKVPGTSVYSASKAALSRFTEVLAAEMEPRNIRCFTISPGLVKGTDMI 237
Query: 202 QALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLS 236
Q LP E ++ + + E++ V L S
Sbjct: 238 QNLPVEAKEMLERTIGASGTSAPAEIAEEVWSLYS 272
>Hs4507185 [Q] KOG1204 Predicted dehydrogenase
Length = 261
Score = 57.0 bits (136), Expect = 3e-08
Identities = 62/208 (29%), Positives = 97/208 (45%), Gaps = 13/208 (6%)
Query: 10 IALVTGASTGVGEGIA---RALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEV 64
+ L+TGAS G G +A +L G+ +V+++R+ +++ + + SG RV+
Sbjct: 9 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA 68
Query: 65 DVTVAKAVEDLIQEIRE----EFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNIN 120
D+ ++ L+ +RE + L+NNAG G G D DS + +N
Sbjct: 69 DLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLS-DSTQVNNYWALN 127
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
T + L SP VVN+S++ L G + Y A K A + Q +ALE
Sbjct: 128 LTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALE 187
Query: 181 YAERNVRVNAVAPGYVSTPKIQALPKET 208
E NVRV APG + T +Q L +ET
Sbjct: 188 --EPNVRVLNYAPGPLDT-DMQQLARET 212
>At5g50130 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 57.0 bits (136), Expect = 3e-08
Identities = 51/213 (23%), Positives = 98/213 (45%), Gaps = 24/213 (11%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVDVTV 68
A++TG ++G+G AR L RG VV+ R + + + I + + +I E+D++
Sbjct: 39 AIITGGTSGIGAETARVLAKRGVRVVMAVRDMKKAEMVKERIIRENPEADIILFEIDLSS 98
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
+V + + L+ L+NNAG+ P+ ++ + TN G + +
Sbjct: 99 LSSVARFCSQFLSQDLPLNILINNAGVFSPNL----EFSEEKIELTFATNFLGHYLLTEM 154
Query: 129 AL-PLMESSSSPDSEAAVVNLSAV--NGL-------------VGIPGISPYTATKHAVIG 172
+ +++++ E ++NLS+V N + + G Y +K A I
Sbjct: 155 LIEKMIDTAEKSGIEGRIINLSSVIHNWVKPDCFSFPKLLHPIRYNGTRAYAQSKLATIL 214
Query: 173 ITQSVALEYAER--NVRVNAVAPGYVSTPKIQA 203
++++ + +R NV +NAV PG V T I+A
Sbjct: 215 HAKALSKQLKDRNANVTINAVHPGIVKTGIIRA 247
>At4g10020 [Q] KOG1205 Predicted dehydrogenase
Length = 389
Score = 57.0 bits (136), Expect = 3e-08
Identities = 48/174 (27%), Positives = 80/174 (45%), Gaps = 9/174 (5%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG-SRVIGKEVDVT 67
K+ ++TGAS+ +GE IA RGA +V+ +R ++ + G + VI DV
Sbjct: 50 KVVVITGASSAIGEQIAYEYAKRGANLVLVARREQRLRVVSNKAKQIGANHVIIIAADVI 109
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDY-DIDSWRQVIDTNINGTFYTL 126
I + +G + +LVN A + H E+ D + ++D N G Y
Sbjct: 110 KEDDCRRFITQAVNYYGRVDHLVNTASL--GHTFYFEEVSDTTVFPHLLDINFWGNVYPT 167
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
ALP + ++ VVN S N L +P +S Y+A K A++ +++ E
Sbjct: 168 YVALPYLHQTNG----RIVVNASVENWL-PLPRMSLYSAAKAALVNFYETLRFE 216
>7297912 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 299
Score = 57.0 bits (136), Expect = 3e-08
Identities = 48/177 (27%), Positives = 76/177 (42%), Gaps = 29/177 (16%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVV---ITSRHLSEVQETAGNIDPSGSRVIGKE 63
+G+I L+TG G+G +A G+TVV I ++ + E A ++ V
Sbjct: 53 SGEIVLITGTGHGIGRELALHYASLGSTVVCVDIDGKNNLQTVEKAKRLNLG--EVYSYS 110
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
DV+ V L I+ + G + LVNN GI H I + ++V D G
Sbjct: 111 CDVSKRDEVTALADRIKSDVGCISVLVNNVGIMPTHP--ILQQSAEEIQRVFDEKCRGH- 167
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
++ +S++ GLVGI + PY ATK AV G+ +++ E
Sbjct: 168 ---------------------IICMSSIAGLVGISNLVPYCATKFAVRGLMEALHAE 203
>CE09505 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 249
Score = 56.6 bits (135), Expect = 3e-08
Identities = 53/208 (25%), Positives = 101/208 (48%), Gaps = 23/208 (11%)
Query: 9 KIALVTGASTGVGEGIARALFVRG--ATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
K L+TGA+ G+G G+ + ++ T R S+ +E + D SR+ +D+
Sbjct: 4 KSLLITGANRGIGLGLLKQFLKHKDIQIIIATCRDPSKAEELSNLKD---SRLHILPLDI 60
Query: 67 TVAKAVEDLIQEIREEFG--ALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
+++ L E+ + G L L+NNAGI P+ E RQ ++TN T
Sbjct: 61 DCDESISKLYAEVEKLVGEDGLTVLLNNAGILLPYDVEGEKNRKTLIRQ-LETNSVSTAL 119
Query: 125 TLKYALPLMESSSSPD-------SEAAVVNLSA-------VNGLVGIPGISPYTATKHAV 170
+ LPL++ +++ + + AA+VN+S+ ++G P ++ Y +K A+
Sbjct: 120 ITQEFLPLLKKAAAKNGGDGYSINRAAIVNISSTAASVEKIDGTFNGPLVA-YRMSKSAL 178
Query: 171 IGITQSVALEYAERNVRVNAVAPGYVST 198
+S +++ A+ ++ V + PG+V T
Sbjct: 179 NSFAKSCSIDLAKYHILVTSFCPGWVKT 206
>7296047 [Q] KOG1205 Predicted dehydrogenase
Length = 321
Score = 56.6 bits (135), Expect = 3e-08
Identities = 44/204 (21%), Positives = 93/204 (45%), Gaps = 12/204 (5%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV 64
S G++ +TGAS+G+G +A +L G +V+++R L ++++ + ++ +
Sbjct: 43 SMRGQVVWITGASSGIGRALALSLARHGVKLVLSARRLEQLEQVQEECLAAARGLLATKD 102
Query: 65 DVTVAKAVEDL------IQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTN 118
+ + + DL + + F L LVNNAG + + + +I+ R++ + +
Sbjct: 103 VLVIQMDMLDLDEHKTHLNTVLNHFHRLDVLVNNAGRS--QRASWTEVEIEVDRELFELD 160
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA 178
+ + + + + A S++ G +P Y A KHA+ S+
Sbjct: 161 VFAVVHLSRLVVRYFVEQNGGRGHIAAT--SSIAGFSPVPFSPTYCAAKHALNAYLLSLK 218
Query: 179 LEYAERNVRVNAVAPGYVSTPKIQ 202
+E R + V+ APG ++T +Q
Sbjct: 219 VEM--RKLDVSLFAPGPIATDFLQ 240
>CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 315
Score = 56.2 bits (134), Expect = 4e-08
Identities = 55/201 (27%), Positives = 91/201 (44%), Gaps = 26/201 (12%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVAK 70
A+VTGA+ G+G+ + L RG V I SR S++++T +I + K+ D+ V
Sbjct: 50 AVVTGATDGIGKSYSFELARRGFNVYIVSRTQSKLEQTKKDI-------LEKQPDIEVRF 102
Query: 71 AVED-----------LIQEIREEFGALHYLVNNAGITGPHQTGIEDYD--IDSWRQVIDT 117
A D L+ ++ E ++ L+NN G+ + + + IDS VI
Sbjct: 103 ATYDFTNPSVTDYEKLLSKLNEV--SVGILINNVGMFFDYPEMLHKINGGIDSIANVIII 160
Query: 118 NINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV 177
N LP M S + +VN+ + G+V + S Y+ATK V +T +
Sbjct: 161 NTLPATLLSAGILPQMVSRKA----GIIVNIGSFAGVVKLAEWSIYSATKKYVEWLTGCL 216
Query: 178 ALEYAERNVRVNAVAPGYVST 198
EY+ + A+ P V+T
Sbjct: 217 RKEYSHHGIIFQAITPAMVAT 237
>YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 326
Score = 55.8 bits (133), Expect = 6e-08
Identities = 52/199 (26%), Positives = 93/199 (46%), Gaps = 20/199 (10%)
Query: 6 FAGKIALVTGASTGVGEGIARALFVRGATVVITSRHL--SEVQETAGNIDPSGSRVIGKE 63
F I L+TG S G+G I L + + I + + S V+ T RV
Sbjct: 68 FKNGIVLITGGSKGLGRAIVSQLLQDYSNLTILNVDICPSSVRNT---------RVKDLI 118
Query: 64 VDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGT 122
D++ + V L+ ++ ++ + +VNNAG+ + TG + D+ ++ N T
Sbjct: 119 CDLSDDEEVAALLNLLKRKYKNEIRLIVNNAGVRA-NFTGFNGMERDNLDKIFKIN---T 174
Query: 123 FYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYA 182
F L++ L S S + +VN++++ G++ ++ Y A+K A+I QS + E
Sbjct: 175 FAPLQFIQELAPSRHST-RQCYIVNIASILGILTPAKVAAYAASKAALIAFHQSYSFELQ 233
Query: 183 E---RNVRVNAVAPGYVST 198
RN+R V PG ++T
Sbjct: 234 NEGVRNIRTLLVTPGQLNT 252
>CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 249
Score = 55.8 bits (133), Expect = 6e-08
Identities = 57/217 (26%), Positives = 103/217 (47%), Gaps = 37/217 (17%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVI---TSRHLSEVQETAGNIDPSGSRVIGKE 63
A K L+TGA+ G+G G+ + F++ V I T R S E D +RV +
Sbjct: 2 APKSILITGANRGIGLGLLKQ-FIKNKDVQIIIGTCRDPSNATELNSIKD---TRVHILQ 57
Query: 64 VDVTVAKAVEDLIQEIREEFG--ALHYLVNNAGITGPHQTGIEDYDIDSWR------QVI 115
+D+ ++ L E+ + G L L+NNAGI P YDID + + +
Sbjct: 58 LDIDCDDSIRKLGAEVEKLVGEDGLTVLINNAGIFVP-------YDIDGEKSRSTLIRQL 110
Query: 116 DTNINGTFYTLKYALPLMESSSSPD-------SEAAVVNLSAVNGLV-------GIPGIS 161
+TN T + LPL++ +++ + + +A++N+S+ G + IP ++
Sbjct: 111 ETNTISTVLITQELLPLLKRAAAKNRGEGYSINRSAIINISSTAGSITKIDASYNIPLVA 170
Query: 162 PYTATKHAVIGITQSVALEYAERNVRVNAVAPGYVST 198
Y +K A+ +S +++ A+ ++ V PG+V T
Sbjct: 171 -YRMSKSALNSFGKSCSVDLAKYHILVTTFCPGWVKT 206
>CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 333
Score = 55.5 bits (132), Expect = 7e-08
Identities = 59/195 (30%), Positives = 90/195 (45%), Gaps = 14/195 (7%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVDVTV 68
A+VTGA+ G+G+ A L RG V++ SR S++ ET I S V D T
Sbjct: 67 AVVTGATDGIGKAYAFELARRGFNVLLVSRTQSKLDETKKEILEKYSSIEVRTAAFDFTN 126
Query: 69 A--KAVEDLIQEIRE-EFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
A A +DL+ + + E G L+NN G++ + + D R T IN T
Sbjct: 127 AAPSAYKDLLATLNQVEIGV---LINNVGMSYEYPDVLHKVDGGIERLANITTINTLPPT 183
Query: 126 LKYA--LPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAE 183
L A LP M + + +VN+ + G + + Y+ATK V +T + EY
Sbjct: 184 LLSAGILPQMVARKA----GVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRKEYEH 239
Query: 184 RNVRVNAVAPGYVST 198
+ + V +AP V+T
Sbjct: 240 QGITVQTIAPMMVAT 254
>SPCC1450.15_1 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 373
Score = 55.5 bits (132), Expect = 7e-08
Identities = 51/192 (26%), Positives = 91/192 (46%), Gaps = 10/192 (5%)
Query: 12 LVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPS----GSRVIGKEVDVT 67
LVTG S G+G+ IA+ L +RGA V I +R ++++QE + S +V + VD+T
Sbjct: 26 LVTGGSQGLGKAIAKELVLRGANVTIVARTVTKLQEAVAELSDSKIHEDQQVSFESVDLT 85
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
++V +I+ R F H +V+ AG P + D + + + N + Y
Sbjct: 86 SYESVHSMIE--RLPFCPDH-VVHCAGSCIP--GFFTELDPSVFEKQMRQNYLASVYVCH 140
Query: 128 YALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNVR 187
A+ M+ SP ++ + ++ + I G S Y+ K AV + S+ E ++
Sbjct: 141 AAIRRMK-EISPSYSRRILLVGSLLSSLPIIGYSAYSPVKAAVRNLADSLRQECILYDIE 199
Query: 188 VNAVAPGYVSTP 199
V+ P + +P
Sbjct: 200 VSVYLPSTILSP 211
>Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 55.1 bits (131), Expect = 1e-07
Identities = 53/192 (27%), Positives = 83/192 (42%), Gaps = 12/192 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K +TG +G G+ +AR L RG V+ ++ G + R+ +DVT
Sbjct: 30 KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQ---TSDRLETVTLDVTK 86
Query: 69 AKAVEDLIQEIRE--EFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
++V Q ++E L LVNNAGI+ P E ++D N+ G
Sbjct: 87 TESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPN-ELLTKQDLLTILDVNLLGVIDVT 145
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
LPL+ + VVN+ +V G V + G Y +K+ V + S+ E + V
Sbjct: 146 LNLLPLVRR-----ARGRVVNVFSVMGRVSLFG-GGYCISKYGVEAFSDSLRRELSYFGV 199
Query: 187 RVNAVAPGYVST 198
+V + PGY T
Sbjct: 200 KVAMIEPGYFKT 211
>At1g64590 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 334
Score = 55.1 bits (131), Expect = 1e-07
Identities = 54/210 (25%), Positives = 94/210 (44%), Gaps = 26/210 (12%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVDVTV 68
A++TGA++G+G AR L RGA +V+ +R + +ET I + + +I +D++
Sbjct: 37 AIITGATSGIGAETARVLAKRGARLVLPARSVKTAEETKARILSEFPDAEIIVMHLDLSS 96
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
+V + + L+ L+NNAG H+ + + D TN G F K
Sbjct: 97 LTSVRRFVDDFESLNLPLNILINNAG-KYAHKHALSE---DGVEMTFATNYLGHFLLTKL 152
Query: 129 AL-PLMESSSSPDSEAAVVNLSAV-------NGLVGIPGIS----PYTATKHAVIG---- 172
L ++E+++ + +VN+++V + L + IS Y AT+ +
Sbjct: 153 LLKKMIETAAQTGVQGRIVNVTSVVHSWFSGDMLQYLADISRNNRNYDATRAYALSKLAN 212
Query: 173 ----ITQSVALEYAERNVRVNAVAPGYVST 198
+ S L + NV N V PG V T
Sbjct: 213 VLHTVELSRLLHKMDANVTANCVHPGIVKT 242
>SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 54.7 bits (130), Expect = 1e-07
Identities = 50/201 (24%), Positives = 84/201 (40%), Gaps = 8/201 (3%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEV 64
S KI + G + G+G + + L R TVV S E S S V ++
Sbjct: 2 STTNKIYFIAGGNRGIGLSLVKELSNREGTVVFASARKPEAATELQEWSKSHSNVHIIKL 61
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
D++ ++ + QE+ + G + L N+GI T + D D W TN+ G +
Sbjct: 62 DISSLESANEAAQEVAKAVGKVDVLWVNSGIFHSFNTVLNTPD-DVWNSHYKTNVLGPIH 120
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVG--IP-GISPYTATKHAVIGITQSVALEY 181
+ PL++ S +V S++ G +G P S Y +K A+ + ++ E
Sbjct: 121 VYQAFYPLVKKGES----KIIVFTSSLVGSMGAFFPFNQSGYGQSKAALNFTMKEISFEL 176
Query: 182 AERNVRVNAVAPGYVSTPKIQ 202
+ V ++ PG V T Q
Sbjct: 177 QDEGFIVISIHPGMVRTDSAQ 197
>Hs4502601 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 277
Score = 54.7 bits (130), Expect = 1e-07
Identities = 43/151 (28%), Positives = 73/151 (47%), Gaps = 9/151 (5%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVR-GATVVITSRHLSEVQETAGNIDPSGSRVIGKE 63
S ++ALVTGA+ G+G IAR L + VV+T+R ++ Q + G +
Sbjct: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
+D+ +++ L +R+E+G L+ LVNNA + + +DI + + TN T
Sbjct: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPM-PFDIKA-EMTLKTNFFATR 119
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGL 154
LP+M+ VVN+S++ L
Sbjct: 120 NMCNELLPIMK------PHGRVVNISSLQCL 144
>YBR159w [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 347
Score = 54.3 bits (129), Expect = 2e-07
Identities = 43/191 (22%), Positives = 88/191 (45%), Gaps = 8/191 (4%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVT 67
GK +TGAS G+G+ AR + RG +V+ SR S+++ ++ V+ K + +
Sbjct: 62 GKYCAITGASDGIGKEFARQMAKRGFNLVLISRTQSKLEALQKELEDQ-HHVVVKILAID 120
Query: 68 VAKAVEDLIQEIREEFGAL--HYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
+A+ E + I+E L LVNN G + + + R +I N T
Sbjct: 121 IAEDKESNYESIKELCAQLPITVLVNNVGQSHSIPVPFLETEEKELRNIITINNTATLLI 180
Query: 126 LKYALPLMESSSSPDSEAA-----VVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
+ P + + +++ + ++ + + GL+ P ++ Y+ +K + G + S+A E
Sbjct: 181 TQIIAPKIVETVKAENKKSGTRGLILTMGSFGGLIPTPLLATYSGSKSFLQGWSNSLAGE 240
Query: 181 YAERNVRVNAV 191
++ + V +
Sbjct: 241 LSKDAIDVELI 251
>Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 387
Score = 54.3 bits (129), Expect = 2e-07
Identities = 47/190 (24%), Positives = 89/190 (46%), Gaps = 13/190 (6%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVV--ITSRHLSEVQETAGNIDPSGSRVIGKEVDV 66
K LVTG G+G + + L G TV + + + +E P R+ ++D+
Sbjct: 83 KAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSP---RLSVLQMDI 139
Query: 67 TVAKAVEDLIQEIRE--EFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
T ++D ++ + L ++NNAG+ G T E + ++Q + N GT
Sbjct: 140 TKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLG-FPTDGELLLMTDYKQCMAVNFFGTVE 198
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAER 184
K LPL+ S+ +VN+S++ G + ++ Y ++K AV + + LE ++
Sbjct: 199 VTKTFLPLLRK-----SKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKW 253
Query: 185 NVRVNAVAPG 194
++V ++ PG
Sbjct: 254 GIKVASIQPG 263
>Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 313
Score = 54.3 bits (129), Expect = 2e-07
Identities = 53/198 (26%), Positives = 91/198 (45%), Gaps = 24/198 (12%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVV---ITSRHLSEVQETAGNIDPSGSRVIGKEVD 65
K +TG +G G +A+ L RG V+ T ++Q + R+ +D
Sbjct: 26 KYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQR------DTSYRLQTTLLD 79
Query: 66 VTVAKAVEDLIQEIREEFG--ALHYLVNNAGI---TGPHQTGIEDYDIDSWRQVIDTNIN 120
VT +++++ Q +R++ G L LVNNAG+ +GP+ E D + +VI+ N+
Sbjct: 80 VTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPN----EWLTKDDFVKVINVNLV 135
Query: 121 GTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALE 180
G + LP+++ + VVN+S+ G V + G Y +K V + S+ E
Sbjct: 136 GLIEVTLHMLPMVKR-----ARGRVVNMSSSGGRVAVIG-GGYCVSKFGVEAFSDSIRRE 189
Query: 181 YAERNVRVNAVAPGYVST 198
V+V + PG T
Sbjct: 190 LYYFGVKVCIIEPGNYRT 207
>CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 54.3 bits (129), Expect = 2e-07
Identities = 59/201 (29%), Positives = 91/201 (44%), Gaps = 26/201 (12%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVA- 69
A+VTGA+ G+G+ + L RG V I SR S+++ T I + +++V A
Sbjct: 50 AVVTGATDGIGKSYSFELAKRGFNVYIVSRTQSKLEHTKKEI-----LEVHPDIEVRFAT 104
Query: 70 --------KAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYD--IDSWRQVIDTNI 119
E L+ ++ E ++ L+NN G+ + + + IDS V T I
Sbjct: 105 FDFTNPSVSDYEKLLSKLNEV--SIGILINNVGMFFDYPEMLHKINGGIDSIANV--TII 160
Query: 120 NGTFYTLKYA--LPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV 177
N TL A LP M P +VN+ +V GL + S Y+ATK V IT +
Sbjct: 161 NTLPATLLSAGILPQMV----PRKAGIIVNIGSVAGLATMAEWSVYSATKKYVEWITGCL 216
Query: 178 ALEYAERNVRVNAVAPGYVST 198
EY + + A+ P V+T
Sbjct: 217 QKEYGHQGIIFQAITPAMVAT 237
>Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase
Length = 244
Score = 54.3 bits (129), Expect = 2e-07
Identities = 60/212 (28%), Positives = 98/212 (45%), Gaps = 21/212 (9%)
Query: 7 AGKIALVTGASTGVGEGIARALFV---RGATVVITSRHLS---EVQETAGNIDPSGSRVI 60
A + L+TG S+G+G +A L + V T R L + E A + +
Sbjct: 2 ARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLE 61
Query: 61 GKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGI--TGPHQTGIEDYDIDSWRQVIDTN 118
++DV +K+V + + E G + LV NAG+ GP +E D+ V+D N
Sbjct: 62 TLQLDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGP----LEALGEDAVASVLDVN 115
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA 178
+ GT L+ LP M+ S V+ +V GL+G+P Y A+K A+ G+ +S+A
Sbjct: 116 VVGTVRMLQAFLPDMKRRGS----GRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLA 171
Query: 179 LEYAERNVRVNAVAPGYVST---PKIQALPKE 207
+ V ++ + G V T K+ P+E
Sbjct: 172 VLLLPFGVHLSLIECGPVHTAFMEKVLGSPEE 203
>CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 53.9 bits (128), Expect = 2e-07
Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 25/203 (12%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVAK 70
A+VTGA+ G+G A L RG + + SR S++ +T +++ K D+ V
Sbjct: 56 AVVTGATDGIGRSYALDLARRGFNIFLISRTKSKLVKTK-------KQILNKYSDIEVRY 108
Query: 71 AVEDLIQEIREEFGALHY---------LVNNAGI--TGPHQTGIEDYDIDSWRQVIDTNI 119
A+ D + E++ L + L+NN G+ P + ID+ VI+ NI
Sbjct: 109 AICDFTRVSYEDYKRLLHSLNEVDIGILINNVGMCFDNPEVLHRVEGGIDTLTNVINVNI 168
Query: 120 NGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVAL 179
LP M + S +VN+ + G + + S Y+ATK + T +
Sbjct: 169 ---LPLTAGILPQMMARKS----GIIVNIGSAAGSIHMAKWSVYSATKKYIEWFTSILQK 221
Query: 180 EYAERNVRVNAVAPGYVSTPKIQ 202
EY + + P VST I+
Sbjct: 222 EYENEGIICQTITPLLVSTNMIK 244
>At2g37540 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 321
Score = 53.9 bits (128), Expect = 2e-07
Identities = 56/209 (26%), Positives = 99/209 (46%), Gaps = 26/209 (12%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRH---LSEVQETAGNIDPSGSRVIGKEVDVT 67
A++TG ++G+G AR L +RGA V+I +R+ +E +E ++P+ +RV ++DV+
Sbjct: 36 AIITGGTSGIGLEAARVLAMRGAHVIIAARNPKAANESKEMILQMNPN-ARVDYLQIDVS 94
Query: 68 VAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
K+V + + L+ L+NNAG+ ED I+S TN G F
Sbjct: 95 SIKSVRSFVDQFLALNVPLNILINNAGVMFCPFKLTED-GIES---QFATNHIGHFLLTN 150
Query: 128 YALPLMESSSSPDS-EAAVVNLSA---------------VNGLVGIPGISPYTATKHAVI 171
L M+S++ + +VNLS+ +N G Y +K + +
Sbjct: 151 LLLDKMKSTARESGVQGRIVNLSSIAHTYTYSEGIKFQGINDPAGYSERRAYGQSKLSNL 210
Query: 172 GITQSVALEYAER--NVRVNAVAPGYVST 198
+ +++ E N+ +N+V PG V+T
Sbjct: 211 LHSNALSRRLQEEGVNITINSVHPGLVTT 239
>SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 341
Score = 53.5 bits (127), Expect = 3e-07
Identities = 44/187 (23%), Positives = 82/187 (43%), Gaps = 8/187 (4%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIGKEV 64
G A+VTGA+ G+G+ A L + G VV+ SR ++ A ++ +R I +
Sbjct: 57 GYWAVVTGATDGIGKEYATQLAMSGFNVVLISRTQEKLDALAKELETVAKVKTRTIAIDY 116
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
T A+ E L Q++ + L+NN G + T + + ++ N GT +
Sbjct: 117 TKTTAETFEKLHQDLVGT--PITVLINNVGQSHYMPTSFAETTVKEMDDIMHINCFGTLH 174
Query: 125 TLKYALPLM---ESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY 181
T K L +M + ++ + + GL+ P +S Y +K + + S+ E
Sbjct: 175 TTKAVLSIMLRERQKNEKGPRCLILTMGSFAGLLPSPYLSTYAGSKAFLSNWSASLGEEV 234
Query: 182 AERNVRV 188
++ + V
Sbjct: 235 KKQGIDV 241
>CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 53.5 bits (127), Expect = 3e-07
Identities = 54/207 (26%), Positives = 98/207 (47%), Gaps = 26/207 (12%)
Query: 12 LVTGASTGVGEGIARALFVRGAT---VVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
+VTGA+ G+G G+ + L V+ ++ T+R + + E D SRV + VT
Sbjct: 7 VVTGANRGIGLGLVQQL-VKDKNIRHIIATARDVEKATELKSIKD---SRVHVLPLTVTC 62
Query: 69 AKAVEDLIQEIREEFGA--LHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
K+++ + ++ E G+ L L+NNAG+ + T E Q +D N
Sbjct: 63 DKSLDTFVSKVGEIVGSDGLSLLINNAGVLLSYGTNTEPNRAVIAEQ-LDVNTTSVVLLT 121
Query: 127 KYALPLMESSSSPD-------SEAAVVNLSA--------VNGLVGIPGISPYTATKHAVI 171
+ LPL+++++S + S AAV+ +S+ +G P + Y +K A+
Sbjct: 122 QKLLPLLKNAASKESGDQLSVSRAAVITISSGLGSITDNTSGSAQFP-VLAYRMSKAAIN 180
Query: 172 GITQSVALEYAERNVRVNAVAPGYVST 198
+++A++ + NV V PG+V T
Sbjct: 181 MFGRTLAVDLKDDNVLVVNFCPGWVQT 207
>7297326 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 409
Score = 53.5 bits (127), Expect = 3e-07
Identities = 49/200 (24%), Positives = 90/200 (44%), Gaps = 14/200 (7%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSE----VQETAGNIDPSGSRVIGKE 63
G+ AL+TGA+ G+G AR+L G ++ R+ S ++ A + SR
Sbjct: 121 GRTALITGANCGIGYETARSLAHHGCEIIFACRNRSSAEAAIERIAQERPAARSRCRFAA 180
Query: 64 VDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQT----GIE-DYDIDSWRQVIDTN 118
+D++ ++V+ ++EI++ + YL+ NAG+ T G+E + + T
Sbjct: 181 LDLSSLRSVQRFVEEIKQSVSHIDYLILNAGVFALPYTRTVDGLETTFQVSHLSHFYLTL 240
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIP----GISPYTATKHAVIGIT 174
T + K + ++ S S + V NL AV+ L P + Y K +
Sbjct: 241 QLETLFDYKTRIIVLSSESHRFANLPVENL-AVHHLSPPPEKYWSMMAYNNAKLCNVLFA 299
Query: 175 QSVALEYAERNVRVNAVAPG 194
Q +A + +R + V ++ PG
Sbjct: 300 QELAQRWKQRGISVFSLHPG 319
>Hs21553325 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 330
Score = 53.1 bits (126), Expect = 4e-07
Identities = 49/206 (23%), Positives = 85/206 (40%), Gaps = 20/206 (9%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVDV 66
++A+VTG + G+G A+ L G V+I + S+ ++ I + +V D+
Sbjct: 44 RVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDL 103
Query: 67 TVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
++ +Q+ + + LH L+NNAG+ Q D + + N G F
Sbjct: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTR----DGFEEHFGLNYLGHFLLT 159
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGI------------SPYTATKHAVIGIT 174
L ++ S SP A VV +S+ V + + Y +K A++ T
Sbjct: 160 NLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFT 219
Query: 175 QSV--ALEYAERNVRVNAVAPGYVST 198
+ L +V N V PG V+T
Sbjct: 220 YHLQRLLAAEGSHVTANVVDPGVVNT 245
>CE27908 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 319
Score = 53.1 bits (126), Expect = 4e-07
Identities = 37/133 (27%), Positives = 66/133 (48%), Gaps = 6/133 (4%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVVITSRH--LSEVQETAGNIDPSGSRVIGKEV 64
+GK +TG ++G+G A+AL ++GA VV+ +R+ SE + + I+ +++ +
Sbjct: 27 SGKTFAITGTTSGIGVETAKALILKGAHVVMINRNYTASEASKKSLLIETPNAQIDIVQC 86
Query: 65 DVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
D+ +V+ E E+ LH L+ NAG+ GP E D + N F
Sbjct: 87 DLNSLSSVKKAADEYLEQKWPLHGLILNAGVFGPS----EKTTSDGFEAHFGINHLAHFI 142
Query: 125 TLKYALPLMESSS 137
+K LP++ S+
Sbjct: 143 LIKELLPVLRESA 155
>CE03613 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 262
Score = 53.1 bits (126), Expect = 4e-07
Identities = 51/211 (24%), Positives = 97/211 (45%), Gaps = 20/211 (9%)
Query: 7 AGKIALVTGASTGVGEGIARALF-VRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVD 65
A K +TGA+ G+G GI R L V V+I E + + +R+ VD
Sbjct: 2 APKTVFITGANRGIGLGIVRKLLKVSEIEVIIAGARNLEAANELRELAKADNRLHAITVD 61
Query: 66 VTVAKAVEDLIQEIREEFG--ALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
V + + + ++++ G L+ L+NNAG ++T + + + D N G+
Sbjct: 62 VANDERLANSVKQVESLVGDRGLNLLINNAGCYELYET-TDSPSRKASLKCFDVNAVGSL 120
Query: 124 YTLKYALPLMESSSS-------PDSEAAVVNLSA------VNGLVGIPGIS-PYTATKHA 169
+ LPL++ +++ S AA++N+ + +NG + +S Y +K A
Sbjct: 121 MASQLFLPLLKKAAAHTHITGLSASRAAILNIGSDCSSQFLNGTPTVNDVSIAYKMSKVA 180
Query: 170 VIGITQSVALEYAERN--VRVNAVAPGYVST 198
++ +S+A ++ N V + + PG+V T
Sbjct: 181 MLSFARSLASDFRTLNIPVLIATIHPGWVLT 211
>CE05118 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 325
Score = 52.8 bits (125), Expect = 5e-07
Identities = 60/245 (24%), Positives = 102/245 (41%), Gaps = 28/245 (11%)
Query: 5 SFAGKIALVTGASTGVG----EGIARALFVRGATVVITSR-----------HLSEVQETA 49
S KIA+VTGAS G G +G+A L G T+ IT R +L ++ TA
Sbjct: 2 SLKSKIAIVTGASRGCGRGMLKGVALQLAEAGCTLYITGRAPSKTLSSELTYLPTLEGTA 61
Query: 50 GNIDPSGSRVIGKEVDVTVAKAVEDLIQEIREEF-GALHYLVNNAGITGPHQTGIED--- 105
G + VD + VE E+ E L LVNNA + + G D
Sbjct: 62 EECRKRGGICHVRYVDHSNMDEVEKFFDEVASETDNQLDILVNNA-FSAVTKCGSGDTRK 120
Query: 106 ---YDIDSWRQVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISP 162
D + W + + + +Y Y +M + + +VN+S++ G++ + ++
Sbjct: 121 FFERDPEIWDDINNVGLRNQYYCSVYGTRIMRKNG---MKGLIVNISSLGGIMYLFTVA- 176
Query: 163 YTATKHAVIGITQSVALEYAERNVRVNAVAPGYVSTPKI-QALPKETQQWMSSQHPMKRM 221
Y K A+ ++ +A E + + V ++ P V T I + W ++++ M
Sbjct: 177 YGVGKMALDRMSSDMAQELQDTGITVISLWPSAVKTELITNMIETSAGSWGATENKMFLN 236
Query: 222 ATMTE 226
TE
Sbjct: 237 GESTE 241
>CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 52.4 bits (124), Expect = 6e-07
Identities = 52/217 (23%), Positives = 100/217 (45%), Gaps = 40/217 (18%)
Query: 9 KIALVTGASTGVGEGIARALFVRGAT---VVITSRHLSEVQETAGNIDPSGSRVIGKEVD 65
K ++TGA+ G+G G+ + FV+ ++ T+R + + + DP RV +++
Sbjct: 4 KSVVITGANRGIGLGLVQE-FVKDKNIRHIIATARDVEKATDLKAISDP---RVTALQLE 59
Query: 66 VTVAKAVEDLIQEIREEFGA--LHYLVNNAGITGPHQTGIEDYDIDS------WRQVIDT 117
VT K+++ + ++ E G+ L+ LVNNAG DY + + + ++
Sbjct: 60 VTCDKSMDTFVSKVEEIVGSDGLNLLVNNAG-------NAVDYPCKAKPNRALFAEQLNV 112
Query: 118 NINGTFYTLKYALPLMESSSS-------PDSEAAVVNLSAVNGLVGI---------PGIS 161
N + +PL+ +SS S AAVV +S +GL + P
Sbjct: 113 NTTSVVILTQKLMPLLIKASSKVSGDQLSASRAAVVTIS--SGLASMTDFATGGHAPNAF 170
Query: 162 PYTATKHAVIGITQSVALEYAERNVRVNAVAPGYVST 198
Y +K A+ +++A + + ++ V ++ PG+V T
Sbjct: 171 AYRISKAAINMFGRALANDMKDDHILVASIGPGWVKT 207
>At5g15940 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 346
Score = 52.4 bits (124), Expect = 6e-07
Identities = 44/149 (29%), Positives = 75/149 (49%), Gaps = 15/149 (10%)
Query: 10 IALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG--SRVIGKEVDVT 67
I ++TGA++G+G+ A AL +G VV+ R + ET I +++ E D++
Sbjct: 43 ICVITGATSGLGKATAFALAEKGFYVVLVGRSSQLLSETLKEIKNKNKDAQLKSFEADMS 102
Query: 68 VAKAVEDLIQEIRE--EFGALH----YLVNNAGITGPHQTGIEDYDIDSWRQVIDTNING 121
+++ + + ALH LVNNAGI ID + ++I TN G
Sbjct: 103 SFESIFTFKNSLEQWLSDSALHPSIQVLVNNAGILATSSRP----TIDGYDRMIATNYVG 158
Query: 122 TFYTLKYALPLMESSSSPDSEAAVVNLSA 150
F+ K LPL+++S+ P + VVN+++
Sbjct: 159 PFFLTKLLLPLLKNSNVP---SRVVNVTS 184
>Hs4502599 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 277
Score = 52.0 bits (123), Expect = 8e-07
Identities = 47/171 (27%), Positives = 76/171 (43%), Gaps = 17/171 (9%)
Query: 10 IALVTGASTGVGEGIARALF-VRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
+ALVTG + G+G I R L + VV+T+R ++ Q + G ++D+
Sbjct: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 66
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGI----TGPHQTGIEDYDIDSWRQVIDTNINGTFY 124
+++ L +R+E+G L LVNNAGI P I+ + TN GT
Sbjct: 67 LQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQA------EVTMKTNFFGTRD 120
Query: 125 TLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQ 175
LPL++ + VVN+S++ + + SP K IT+
Sbjct: 121 VCTELLPLIK------PQGRVVNVSSIMSVRALKSCSPELQQKFRSETITE 165
>7290709 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 406
Score = 52.0 bits (123), Expect = 8e-07
Identities = 50/203 (24%), Positives = 85/203 (41%), Gaps = 17/203 (8%)
Query: 8 GKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI-DPS-GSRVIGKEVD 65
GK+ +VTG +TG+G+ L RGA V + R + +I D S ++ + +D
Sbjct: 74 GKVVIVTGCNTGIGKETVLELAKRGARVYMACRDPGRCEAARLDIMDRSRNQQLFNRTLD 133
Query: 66 VTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYT 125
+ ++V + ++ + E L L+NNAG+ +T D + Q N G F
Sbjct: 134 LGSLQSVRNFVERFKAEESRLDILINNAGVMACPRT----LTADGFEQQFGVNHLGHFLL 189
Query: 126 LKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGI----------SPYTATKHAVIGITQ 175
L ++ SSP V + + + G + + Y+ +K A I T
Sbjct: 190 TNLLLDRLK-HSSPSRIVVVSSAAHLFGRINREDLMSEKNYSKFFGAYSQSKLANILFTL 248
Query: 176 SVALEYAERNVRVNAVAPGYVST 198
++ + V VN PG V T
Sbjct: 249 KLSTILKDTGVTVNCCHPGVVRT 271
>At2g05990 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 390
Score = 51.2 bits (121), Expect = 1e-06
Identities = 67/289 (23%), Positives = 126/289 (43%), Gaps = 50/289 (17%)
Query: 8 GKIALVTGAS--TGVGEGIARALFVRGATVVI----TSRHLSEVQETAGNID-----PSG 56
GK A + G + G G IA++L GA +++ + ++ E G D P G
Sbjct: 94 GKRAFIAGIADDNGYGWAIAKSLAAAGAEILVGTWVPALNIFETSLRRGKFDQSRVLPDG 153
Query: 57 SRVIGKEV---------------DVTVAK--------AVEDLIQEIREEFGALHYLVNNA 93
S + K+V DV K V++ + ++++FG++ LV++
Sbjct: 154 SLMEIKKVYALDAVFDNPEDVPEDVKTNKRYAGSSNWTVQEAAECVKKDFGSIDILVHSL 213
Query: 94 GITGPHQTGIEDYDIDSWRQVIDTNINGTFYT----LKYALPLMESSSSPDSEAAVVNLS 149
GP + +++ R+ I+ + Y+ L++ LP+M + S + +
Sbjct: 214 A-NGPE---VSKPLLETSRKGYLAAISASSYSFVSLLRHFLPIMNPGGASISLTYIASER 269
Query: 150 AVNGLVGIPGISPYTATKHAVIGITQSVALEYAER-NVRVNAVAPGYVSTPKIQALP--K 206
+ G G G+S + K A+ T+ +A E + N+RVN ++ G + + +A+
Sbjct: 270 IIPGYGG--GMS---SAKAALESDTRVLAYEAGRKSNIRVNTISAGPLGSRAAKAIGFID 324
Query: 207 ETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTGSVYPIDGGFLA 255
++ + P+++ T EV N FL SPL TG+ +D G A
Sbjct: 325 TMIEYSYNNGPIQKTLTADEVGNAAAFLASPLASAITGATIYVDNGLNA 373
>At4g24050 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/210 (24%), Positives = 95/210 (44%), Gaps = 26/210 (12%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNI--DPSGSRVIGKEVDVTV 68
A++TGA++G+G AR L RGA ++ +R++ +E I + + ++ ++D++
Sbjct: 37 AVITGATSGIGAETARVLAKRGARLIFPARNVKAAEEAKERIVSEFPETEIVVMKLDLSS 96
Query: 69 AKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKY 128
+V + + + L+ L+NNAG H+ I + D TN G F
Sbjct: 97 IASVRNFVADFESLDLPLNLLINNAGKLA-HEHAISE---DGIEMTFATNYLGHFLLTNL 152
Query: 129 AL-PLMESSSSPDSEAAVVNL-SAVNG-----------LVGIP-----GISPYTATKHAV 170
L +++++ + +VN+ S ++G L+ P Y +K A
Sbjct: 153 LLNKMIQTAEETGVQGRIVNVTSGIHGWFSGDLIEYLRLISQPKCQFDATRAYALSKLAN 212
Query: 171 IGITQSVA--LEYAERNVRVNAVAPGYVST 198
+ T+ ++ L+ NV VN V PG V T
Sbjct: 213 VLHTKELSSRLQKIGANVTVNCVHPGVVRT 242
>CE06157 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 255
Score = 50.4 bits (119), Expect = 2e-06
Identities = 52/213 (24%), Positives = 100/213 (46%), Gaps = 23/213 (10%)
Query: 7 AGKIALVTGASTGVGEGIARALF-VRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVD 65
A K +TGA+ G+G G+ R L V G ++ + + ++ + +R+ VD
Sbjct: 2 APKTIFITGANRGIGLGLVRELLKVPGVEALVAGARNIDGAKELQSLAKADARLHLIAVD 61
Query: 66 VTVAKAVEDLIQEIREEFG--ALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
V+ ++E+ ++ + G L+ L+NNAG+ + T + S ID N
Sbjct: 62 VSNDGSLENSVKSVSGIVGDRGLNLLINNAGLIESYGT-TSAPNRASVLHCIDVNAVSAL 120
Query: 124 YTLKYALPLMESSSS--------PDSEAAVVNLSA--VNGLVGIPGISP------YTATK 167
++ LPL++ ++S PD AA+VN+ + + + + G P Y +K
Sbjct: 121 LASQHFLPLLQKAASHVSGDSLTPD-RAAIVNIGSDCASQALNLRGSGPSNSLLAYKMSK 179
Query: 168 HAVIGITQSVALEY--AERNVRVNAVAPGYVST 198
A++ ++S+A ++ E V + + PG+V T
Sbjct: 180 VAMLSFSRSMAADFKRLEIPVLITNIHPGWVQT 212
>7298168 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 272
Score = 50.4 bits (119), Expect = 2e-06
Identities = 41/133 (30%), Positives = 68/133 (50%), Gaps = 14/133 (10%)
Query: 65 DVTVAKA-VEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTF 123
DVT+A+ ++ E+ + + L+N A T ++ +ID+ I+TN+ G
Sbjct: 64 DVTMAREDMKKYFDEVMVQMDYIDVLINGA-------TLCDENNIDA---TINTNLTGMM 113
Query: 124 YTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVA--LEY 181
T+ LP M+ + +VN+++V GL P Y+A+K VIG T+S+A L Y
Sbjct: 114 NTVATVLPYMDRKMG-GTGGLIVNVTSVIGLDPSPVFCAYSASKFGVIGFTRSLADPLYY 172
Query: 182 AERNVRVNAVAPG 194
++ V V AV G
Sbjct: 173 SQNGVAVMAVCCG 185
>CE28291 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 357
Score = 50.1 bits (118), Expect = 3e-06
Identities = 39/154 (25%), Positives = 71/154 (45%), Gaps = 10/154 (6%)
Query: 1 MSEYSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPS--GSR 58
+ E +GK +TG ++G+G ARAL ++GA VV+ +R++ E ++ I+ +
Sbjct: 29 LKEIDLSGKTYAITGTTSGIGIETARALALKGAHVVMFNRNIVESEKLKKRIEEEKPDVK 88
Query: 59 VIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTN 118
+ D+ ++ + E + LH L+ NAG+ P + D++ N
Sbjct: 89 IDFISCDLNSLQSAKAAADEFLSKHWPLHGLILNAGVFAP----TVKFTFDNFESHFGVN 144
Query: 119 INGTFYTLKYALPLMESSSSPDSEAAVVNLSAVN 152
F K LP + S S A +V +S+V+
Sbjct: 145 HLAQFLLAKELLPALRQS----SPARIVFVSSVS 174
>At4g13250 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 447
Score = 49.7 bits (117), Expect = 4e-06
Identities = 52/222 (23%), Positives = 94/222 (41%), Gaps = 33/222 (14%)
Query: 4 YSFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDP--------- 54
Y + ++TG G+G+ +AR + G V++TSR V T ++
Sbjct: 101 YRAGPRNVVITGR--GLGKALAREFLLSGDRVIVTSRSSESVDMTVKELEQNLKEIMSNA 158
Query: 55 --------SGSRVIGKEVDVTVAKAVEDLIQEIREEFGALHY---------LVNNAGITG 97
S ++V+G DV + VE L +E G+++ +NNAG T
Sbjct: 159 SESARKKLSDAKVVGIACDVCKPEDVEKLSNFAVKELGSINIWVKKHISFCTINNAG-TN 217
Query: 98 PHQTGIEDYDIDSWRQVIDTNINGTFYTLKYALPLMESSSSPDSEAAVVNL-SAVNGLVG 156
+ ++ + Q++ TN+ G+ + A+ +M S S + N+ A +G
Sbjct: 218 KGFRPLLEFTEEDITQIVSTNLIGSILCTRGAMDVM---SRQHSGGHIFNMDGAGSGGSS 274
Query: 157 IPGISPYTATKHAVIGITQSVALEYAERNVRVNAVAPGYVST 198
P + Y +TK + S+ E + NV ++ +PG V T
Sbjct: 275 TPLTAVYGSTKCGLRQFHGSIVKESQKTNVGLHTASPGMVLT 316
>At3g55290 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 135
Score = 49.7 bits (117), Expect = 4e-06
Identities = 31/115 (26%), Positives = 64/115 (54%), Gaps = 8/115 (6%)
Query: 144 AVVNLSAVNGLVG-IPGISPYTATKHAVIGITQSVALEYAERNVRVNAVAPGYVSTPKIQ 202
+V+N+S++ G+ G +PG Y +K V +++ +ALE +RVN++APG + Q
Sbjct: 11 SVINISSIAGIRGMLPGGLAYACSKGGVDTMSRMMALELGVHKIRVNSIAPGLFKSEITQ 70
Query: 203 ALPKETQQWMSS----QHPMKRMATMTE-VSNTVLFLLSPLTGFTTGSVYPIDGG 252
L + ++W+ + P+K T+ +++ V +L+ + + +G+ Y +D G
Sbjct: 71 GLMQ--KEWLKNVTERTVPLKVQQTVDPGLTSLVRYLIHDSSQYISGNTYIVDSG 123
>Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 323
Score = 49.3 bits (116), Expect = 5e-06
Identities = 50/208 (24%), Positives = 86/208 (41%), Gaps = 11/208 (5%)
Query: 9 KIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTV 68
K +TG +G G AR +G V+ L+E TA + S R+ +DVT
Sbjct: 30 KYIFITGCDSGFGNLAARTFDKKGFHVIAAC--LTESGSTALKAETS-ERLRTVLLDVTD 86
Query: 69 AKAVEDLIQEIREEFG--ALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTL 126
+ V+ Q ++ + G L L+NNAG+ G + ++ +R+ I+ N+ G
Sbjct: 87 PENVKRTAQWVKNQVGEKGLWGLINNAGVPGV-LAPTDWLTLEDYREPIEVNLFGLISVT 145
Query: 127 KYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEYAERNV 186
LP + + + L + G YT +K+AV G S+ + V
Sbjct: 146 LNMLPRPQEDQPGQGGTTLPSPCTAGKLPSVGG--GYTPSKYAVEGFNDSLRRDMKAFGV 203
Query: 187 RVNAVAPGYVST---PKIQALPKETQQW 211
V+ + PG T ++ + K+ W
Sbjct: 204 HVSCIEPGLFKTNLADPVKVIEKKLAIW 231
>CE08181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 333
Score = 49.3 bits (116), Expect = 5e-06
Identities = 53/210 (25%), Positives = 93/210 (44%), Gaps = 20/210 (9%)
Query: 5 SFAGKIALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSG---SRVIG 61
S G +A+VTG++ G+G R L +R A V + R + E + G +R+
Sbjct: 43 SAKGLVAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKRMLVRQGCDATRLHF 102
Query: 62 KEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNING 121
E D+T ++V +E E + L+NNAGI + + D + +N G
Sbjct: 103 IECDLTDFESVRRAAKETLESTDTIDILINNAGIMFQSK---HEQTKDGHEKTWQSNHLG 159
Query: 122 TFYTLKYALPLMESSSSP---------DSEAAVVNLSAVNGLVGIPGISPYTATKHAVI- 171
F + LP ++ SS ++ +NL+ V+ + Y +K A +
Sbjct: 160 PFLLTELFLPAVKKSSYARIINVSSRIHLKSEKINLATVDDKKSFGMMKSYRQSKLANVM 219
Query: 172 ---GITQSVALEYAERNVRVNAVAPGYVST 198
+T+ + + AE +V VN++ PG V+T
Sbjct: 220 HARALTKELRKDGAE-HVTVNSLHPGVVNT 248
>CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 349
Score = 49.3 bits (116), Expect = 5e-06
Identities = 52/197 (26%), Positives = 86/197 (43%), Gaps = 18/197 (9%)
Query: 11 ALVTGASTGVGEGIARALFVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVAK 70
A++TG + G+G+ + L RG + I SR S++++T I S V EV
Sbjct: 50 AVITGGTDGIGKSFSFELAKRGFNIYIVSRTQSKLEQTKKEIMEKYSNV---EVRFATFD 106
Query: 71 AVEDLIQEIREEFGALH-----YLVNNAGITGPHQTGIEDY--DIDSWRQVIDTNINGTF 123
I + ++ L+ L+NN G+ + + ID V T +N
Sbjct: 107 FTNPSISDYKKLLSQLNEVSIGMLINNVGMLFEYPENLHKTVGGIDVVANV--TILNTLP 164
Query: 124 YTLKYA--LPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSVALEY 181
TL A LP M S + +VN+ +V G + S Y+A+K V +T + EY
Sbjct: 165 VTLLSAGILPQMVSRKT----GIIVNIGSVAGAAKMAEWSVYSASKKYVEWLTGCLRKEY 220
Query: 182 AERNVRVNAVAPGYVST 198
+ + + A+ P V+T
Sbjct: 221 EHQGIIIQAITPALVAT 237
>Hs13236542 [Q] KOG1205 Predicted dehydrogenase
Length = 181
Score = 48.9 bits (115), Expect = 7e-06
Identities = 33/174 (18%), Positives = 74/174 (41%), Gaps = 4/174 (2%)
Query: 75 LIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLKYALPLME 134
+ IR + + +NNAG+ P + W+ + + N+ + A M+
Sbjct: 1 MFSAIRSQHSGVDICINNAGLARPDT--LLSGSTSGWKDMFNVNVLALSICTREAYQSMK 58
Query: 135 SSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV--ALEYAERNVRVNAVA 192
+ D +N + + ++ + Y+ATK+AV +T+ + L A+ ++R ++
Sbjct: 59 ERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCIS 118
Query: 193 PGYVSTPKIQALPKETQQWMSSQHPMKRMATMTEVSNTVLFLLSPLTGFTTGSV 246
PG V T L + + ++ + + +V+ V+++LS G +
Sbjct: 119 PGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDI 172
>CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 388
Score = 48.5 bits (114), Expect = 9e-06
Identities = 49/201 (24%), Positives = 89/201 (43%), Gaps = 17/201 (8%)
Query: 7 AGKIALVTGASTGVGEGIARALFVRGATVV---ITSRHLSEVQ-ETAGNIDPSGSRVIGK 62
+GK ++TG +G G +A +L + V T + ++ + E P G ++
Sbjct: 31 SGKYVMITGCDSGFGRLLATSLLDKHVNVFAACFTQQGMASLHSEWKLKKGPKG-QLYTL 89
Query: 63 EVDVTVAKAVED----LIQEIREEFGALHYLVNNAGITGPHQTGIEDY-DIDSWRQVIDT 117
++DVT +V+ + + ++E+ L LVNNAGI H G +D+ +D + ++
Sbjct: 90 QLDVTSQASVDSAKSFVTKILKEQNSKLWGLVNNAGIFSIH--GPDDWCSVDEYASSLNV 147
Query: 118 NINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQSV 177
N G +PL++ S +V + + G + ++PY K AV +
Sbjct: 148 NTLGAVRMCHAFVPLIKKS-----RGRIVTMGSTAGRLHGLYVAPYVTAKFAVEAYMDCL 202
Query: 178 ALEYAERNVRVNAVAPGYVST 198
LE V V+ + PG T
Sbjct: 203 RLEMRPFGVSVHILEPGCFKT 223
>7294121 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 482
Score = 48.5 bits (114), Expect = 9e-06
Identities = 37/154 (24%), Positives = 74/154 (48%), Gaps = 13/154 (8%)
Query: 57 SRVIGKEVDVTVAKAVEDLIQEIREEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVID 116
+ + +++D+T ++ + E+ G +VN +G+ ++D I+ Q+
Sbjct: 270 TEIFYQKMDITQKSDIDAAYKATAEKLGHFDVVVNGSGL-------LDDRRIELTIQI-- 320
Query: 117 TNINGTFYTLKYALPLMESSSSPDSEAAVVNLSAVNGLVGIPGISPYTATKHAVIGITQS 176
N+ G + AL M+ S +VN+S+V GL P ++ Y+ +K V T++
Sbjct: 321 -NLVGVINSTLTALEYMDKSKGGRG-GLIVNISSVAGLQPTPLMAIYSTSKTGVTTFTRA 378
Query: 177 VA--LEYAERNVRVNAVAPGYVSTPKIQALPKET 208
+A + YA V + PGY +T ++ + K+T
Sbjct: 379 MASPIHYAHSGVGFITICPGYTNTGILKDIDKKT 412
>7290912 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 247
Score = 48.5 bits (114), Expect = 9e-06
Identities = 46/201 (22%), Positives = 91/201 (44%), Gaps = 15/201 (7%)
Query: 12 LVTGASTGVGEGIARAL--FVRGATVVITSRHLSEVQETAGNIDPSGSRVIGKEVDVTVA 69
L+TG + G+G G+ +AL + + T+ E + ++ + S + E+D+
Sbjct: 5 LITGCNRGLGLGLVKALLNLPQPPQHLFTTCRNREQAKELEDLAKNHSNIHILEIDLRNF 64
Query: 70 KAVEDLIQEIR--EEFGALHYLVNNAGITGPHQTGIEDYDIDSWRQVIDTNINGTFYTLK 127
A + L+ +I + L+ L NNAGI P I + TN K
Sbjct: 65 DAYDKLVADIEGVTKDQGLNVLFNNAGI-APKSARITAVRSQELLDTLQTNTVVPIMLAK 123
Query: 128 YALPLMESSSSPD-------SEAAVVNLSAVNGLV---GIPGISPYTATKHAVIGITQSV 177
LPL++ ++ + AA++N+S++ G + G+ Y +K A+ T+S+
Sbjct: 124 ACLPLLKKAAKANESQPMGVGRAAIINMSSILGSIQGNTDGGMYAYRTSKSALNAATKSL 183
Query: 178 ALEYAERNVRVNAVAPGYVST 198
+++ + + ++ PG+V T
Sbjct: 184 SVDLYPQRIMCVSLHPGWVKT 204
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.314 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,234,286
Number of Sequences: 60738
Number of extensions: 553558
Number of successful extensions: 2015
Number of sequences better than 1.0e-05: 241
Number of HSP's better than 0.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 208
Number of HSP's that attempted gapping in prelim test: 1557
Number of HSP's gapped (non-prelim): 253
length of query: 256
length of database: 30,389,216
effective HSP length: 104
effective length of query: 152
effective length of database: 24,072,464
effective search space: 3659014528
effective search space used: 3659014528
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)