ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV3900 good O KOG0959 Posttranslational modification, protein turnover, chaperones N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV3900 1319185 1322694 1170
(1170 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPR122w [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 757 0.0
SPACUNK4.12c [O] KOG0959 N-arginine dibasic convertase NRD1 and ... 149 3e-35
Hs4826770 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 133 2e-30
At3g57470 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 131 5e-30
At2g41790 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 121 6e-27
YLR389c [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 117 1e-25
7296294 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 107 1e-22
ECU06g0750 [O] KOG0959 N-arginine dibasic convertase NRD1 and re... 106 2e-22
CE06755 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 102 3e-21
CE10402 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 100 2e-20
CE01818 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 93 2e-18
CE06756 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 90 2e-17
At1g06900 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 82 6e-15
7296373 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 80 1e-14
Hs4505453 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 74 2e-12
At3g02090 [O] KOG0960 Mitochondrial processing peptidase beta su... 61 9e-09
7292708 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 59 6e-08
SPBP23A10.15c [O] KOG0960 Mitochondrial processing peptidase bet... 53 2e-06
>YPR122w [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1208
Score = 757 bits (1955), Expect = 0.0
Identities = 437/1167 (37%), Positives = 674/1167 (57%), Gaps = 49/1167 (4%)
Query: 1 MTAATVQTIDVPIYTPISNSNRAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDP 60
M+ V +V Y P+S SNR H+ +L NGI AL+ISDP ++ +S +V TGSHNDP
Sbjct: 1 MSLREVTNYEVSFYIPLSYSNRTHKVCKLPNGILALIISDPTDTSSSCSLTVCTGSHNDP 60
Query: 61 DEVPGLAHLCEHMIISSESKKFPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNK 120
++ GLAHLCEHMI+S+ SKK+P +H L+ + NG+QNAFTTGEQT+FYFE+PN+ N
Sbjct: 61 KDIAGLAHLCEHMILSAGSKKYPDPGLFHTLIAKNNGSQNAFTTGEQTTFYFELPNTQN- 119
Query: 121 TGKPIFDELVGVIADKLGSPIFQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQR 180
G+ F+ ++ V A P+F I+KEI AI +EHE N + +K YH + LA
Sbjct: 120 NGEFTFESILDVFASFFKEPLFNPLLISKEIYAIQSEHEGNISSTTKIFYHAARILANPD 179
Query: 181 SKFSRFSTGNIYTLTQFPIVAGKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKL 240
FSRFSTGNI++L+ P + K I LK+ L ++ +NF ENI++ IRG QS++ L KL
Sbjct: 180 HPFSRFSTGNIHSLSSIPQL--KKIKLKSSLNTYFENNFFGENITLCIRGPQSVNILTKL 237
Query: 241 VQTTFGDFRTKSTIKSQSFSI-------------------------ESFKKLQKVWAARY 275
+ FGD + KS +K +S SI ++FK L W +Y
Sbjct: 238 ALSKFGDIKPKSAVKERSISIRTRSFRRSKSLKKRQDSSKNDYSDLKTFKILNTTWEKKY 297
Query: 276 TEPLFSKQEPETPNSILIQSSKAPILRLVFPVSHQEALFSRSELKIFSKVWSDLFGDESS 335
+ +Q PE NSI I S+K PI+RL+FPVS + F++ ++KI+S +W +LFGDES
Sbjct: 298 KNTMCFQQFPEC-NSIFINSNKVPIMRLLFPVSDKNTRFTKDDIKIYSHLWCELFGDESP 356
Query: 336 GSIHSKFSARNILTRQVTQLSKFTIDDEGLVLQFELTNSGWKTGVESLLTDLFQGFLPFF 395
GS+ +++ LT S+F I D GL+L+ ELTNSGW+ ++ + T + LP F
Sbjct: 357 GSLSYYLASKGWLTGCFAFTSEFAIGDIGLILELELTNSGWE-NIKRITTIVLNRLLPSF 415
Query: 396 QSIDPDEIAQYLNEWNTINLLQFMYQDLDNSTMDKCSDLCSEL---LQCEDPQFILNNSI 452
++ D + +L E N I+L+ F+YQ ++ M++CS L L L+C P I
Sbjct: 416 YVMNIDYLITFLKEQNLIDLVSFLYQSSEDLPMEECSKLSGILQDDLECLTPPNIFKGFK 475
Query: 453 AFSCNRKGSDIGSYYESPKSKEWWNSQAKKFLSFVKTYMSWNNCKLIFLGDLQSNDFLKS 512
+ +I Y + + +WW QA KF +F+K++M+ +N +L+ LG+++S +
Sbjct: 476 SL-IEIDDPNIEKYENTKANIQWWTGQAIKFQNFLKSFMNHDNMRLLLLGNIKSGNIFDK 534
Query: 513 RQVPTNVKFDEHYRFQYELSLIKL----NHVKMSPKDFRLPSSTAFLFGLEKNLSALKQS 568
+ +++ D Y F+Y + + L S +F P+ FL + L+Q
Sbjct: 535 MKNKSDICTDFFYEFEYYTANVHLASDNKFHSNSSYEFNFPTGNLFLPDCVSDPLKLQQL 594
Query: 569 LTAVLRKSQGSALSIITQSKLLQTTPRLMSKNENYELWV-KEENSLEYSSRSVITIELIN 627
KS+ + L S+ +T P+L+S+N+NYE+W+ KE+ + ++SV++ E++
Sbjct: 595 FLECSLKSKFATLRPQIYSEPTRTKPQLVSENQNYEMWILKEDPNFASDNKSVVSFEVLG 654
Query: 628 MGMEPSAKNTMNLEILTQLLYFYINESLYPSERVGYMYQIAANNRGDVRLAVTINGFPQG 687
+G++PS + T++LE+L Q L+ + LYP+ R+GY Y+IA++++G+V L TI+GFP+G
Sbjct: 655 LGIKPSPEATIHLEVLAQALFIITSSFLYPALRIGYTYEIASSSKGNVTLRFTISGFPEG 714
Query: 688 VAMILQIIMDKMVDIGKPDFDITNSMFRHSRILVRTKYEEAARANSCTLASLGVXXXXXX 747
V I++ +D + I ++ R +RILVR KY+ A+ N LAS+G+
Sbjct: 715 VFTIVKTFVDTLKLIATDPTFLSKDTLRKARILVRNKYKNASSDNCVKLASVGLLIVLEK 774
Query: 748 XXXXXXXXXDALEDIDIESFKMFCKDLWIPKSNYMNLVIQGDLSIAETVNQYM-DGIIHH 806
+ALE ++ESF+ FC W ++ L +QG L A+ +N+Y+ + H
Sbjct: 775 YIWTLEDRINALELTELESFEKFCFLFW-RNPKHLVLFMQGSLEYADAINRYLNNNFTQH 833
Query: 807 LSGPNVNQTSVFRLREPETIK-LAQGSNFFIEMTSFKEDPTNSVVYFIETGDRTNPVDYT 865
L N RL P + K L QG+N FI ++DP NS+VYFI+T R + + T
Sbjct: 834 LKISNEGSKPTIRLYPPPSTKDLDQGTNAFISYNGHQDDPNNSIVYFIQTAQRDDIKNLT 893
Query: 866 MSSLFEYFMSMTLVPDLRNKKQIGYVVXXXXXXXXXXXXIHISVMSNLPPHTIEDRIEEY 925
++ L EY S+TLVPDLRNKKQIGY+V IHI+VMS H +E RI EY
Sbjct: 894 LTFLTEYLFSLTLVPDLRNKKQIGYIVLGGLRVLTDTVGIHITVMSGSSGHNLETRINEY 953
Query: 926 LYYLETNVLGAMTEAEFQDNILQKYMQLIKSNSLEKLIKNAGPANLMAQIEASVHSG-NY 984
L YL+ VL TE +F+ +L+ ++ L+K NS ++ +AGP +L+ +I A+V +G NY
Sbjct: 954 LSYLQLQVLNRFTEFDFRRILLEPFLNLLKQNSTKQFEGSAGPVDLLNEIVANVQNGDNY 1013
Query: 985 PSNLQSQGYTVGQHKKLKDEISFRTYAFSE--TKVDVCLLSKLTLQEFKRLFMEKISILS 1042
N + + QH+K++++I+ F E +D+ L KLTL+++ F KISI S
Sbjct: 1014 TLNNKQ----MRQHRKVRNKIAEGRLNFQEDHEMIDISFLQKLTLKKYLAFFESKISIYS 1069
Query: 1043 LQRRKLSVRFKTPMTKPDIGISMMTMQLDGFLKSKGFHITRDELQEIVTKTAGKPTSLFK 1102
QR KLS+ +PM + +I M +QL+ FLK GF I ++L++IV + G P L K
Sbjct: 1070 AQRSKLSIMITSPMAEKEIASRKMFLQLEAFLKINGFAIKNEDLKKIVEHSKGNPILLVK 1129
Query: 1103 ELFHHFRTQGQSLRLCTLVLKEIVKQI 1129
LF +FR + + +L T+VL+EI+K I
Sbjct: 1130 NLFTYFRRRNEVFKLGTVVLQEILKII 1156
>SPACUNK4.12c [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 969
Score = 149 bits (375), Expect = 3e-35
Identities = 209/965 (21%), Positives = 391/965 (39%), Gaps = 144/965 (14%)
Query: 21 NRAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESK 80
+R ++ ++L N + LL+ DP AS V GS ++P E+ GLAH CEH++ +K
Sbjct: 21 DREYRLIKLENDLEVLLVRDPETDNASAAIDVHIGSQSNPRELLGLAHFCEHLLFMG-TK 79
Query: 81 KFPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVI---ADKL 137
K+P + Y L +NG NA+T T++YFE+ + D L G + A
Sbjct: 80 KYPDENEYRKYLESHNGISNAYTASNNTNYYFEVSH----------DALYGALDRFAQFF 129
Query: 138 GSPIFQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTLTQF 197
P+F ++EI+A+D+EH N S + L+ +S FS+F+TGNI TL
Sbjct: 130 IDPLFLEECKDREIRAVDSEHCKNLQSDSWRFWRLYSVLSNPKSVFSKFNTGNIETLGDV 189
Query: 198 PIVAGKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKSTIKSQ 257
P G ++++ L K Y + A + +VI G + L L+ F S IK++
Sbjct: 190 PKELG--LDVRQELLKFYDKYYSANIMKLVIIGREPLDVLQDWAAELF------SPIKNK 241
Query: 258 SFSIESFKKLQKVWAARYTEPLFSKQEPETPNSILIQSSKAPI-----LRLVFPVSHQEA 312
+ I F P T N + P+ L +VFP+ Q
Sbjct: 242 AVPIPKF-----------------PDPPYTDNEVRKICYVKPVKNLRRLDIVFPIPGQYH 284
Query: 313 LFSRSELKIFSKVWSDLFGDESSGSIHSKFSARNILTRQVTQLSKFTIDDEGLVLQFELT 372
+ ++ L G E GS + + + T + T D + +V+ LT
Sbjct: 285 KYKCRP----AEYVCHLLGHEGEGSYLAYLKSLGLATSLIAFNVSITEDADIIVVSTFLT 340
Query: 373 NSGWKTGVESLLTDLFQGFLPFFQSIDPDEIAQYLNEWNTINLLQFMYQDLDNSTMDKCS 432
G T + ++ LF+ + + +D ++L E I + + ++ + + +
Sbjct: 341 EEG-LTDYQRVIKILFE----YIRLLDQTNAHKFLFEETRI-MSEAQFKTRQKTPAYQYA 394
Query: 433 DLCSELLQCEDPQFILNNSIAFSCNRKGSDIGSYYESPKSKEWWNSQAKKFLSFVKTYMS 492
+ + LQ E P+ D YY S ++ K + V +
Sbjct: 395 HVVASKLQREYPR----------------DKVLYYSSVLTE-----FDPKGIQEVVESLR 433
Query: 493 WNNCKLIFLGDLQSNDFLKSRQVPTNVKFDEHYRFQYELS------LIKLNHVKMSPKDF 546
NN F L ++ K + KF Y Y L + L H+K S +
Sbjct: 434 PNN----FFAILAAHSIEKG--LDNKEKF---YGIDYGLEDLDSQFIDSLLHIKTS-SEL 483
Query: 547 RLPSSTAFLFGLEKNLSALKQSLTAVLRKSQGSALSIITQSKLLQTTPRLMSKNENYELW 606
LP + F + +L KQ +T L+ P L+ ++ LW
Sbjct: 484 YLPLANEF---IPWSLEVEKQPVTTKLK------------------VPNLVRNDKFVRLW 522
Query: 607 VKEENSLEYSSRSVITIELINMGMEPSAKNTMNLEILTQLLYFYINESLYPSERVGYMYQ 666
K++++ + ++ + I I+ S K +++ + T+L+ + E YP+ G +
Sbjct: 523 HKKDDTF-WVPKANVFINFISPIARRSPKVSVSTTLYTRLIEDALGEYSYPASLAGLSFS 581
Query: 667 IAANNRGDVRLAVTINGFPQGVAMILQIIMDKMVD--IGKPDFDITNSMFRHSRILVRTK 724
++ + RG + + I+GF + ++L+ ++ M D + F+I + R + L
Sbjct: 582 LSPSTRG---IILCISGFTDKLHVLLEKVVAMMRDLKVHPQRFEILKN--RLEQELKDYD 636
Query: 725 YEEAARANSCTLASLGVXXXXXXXXXXXXXXXDALEDIDIESFKMFCKDLWIPKSNYMNL 784
EA ++ L L +A++D+ + F DL K N++
Sbjct: 637 ALEAYHRSNHVLTWL-----SEPHSWSNAELREAIKDVQVGDMSDFISDLL--KQNFLES 689
Query: 785 VIQGDLSIAETVNQYMDGIIHHLSGPNVNQTSVF--RLREPETIKLAQGSNFFIE-MTSF 841
++ G+ + + N + + ++ VF +L I + +G N+ + +
Sbjct: 690 LVHGNYTEEDAKN------LIESAQKLIDPKPVFASQLSRKRAIIVPEGGNYIYKTVVPN 743
Query: 842 KEDPTNSVVYFIETGDRTNPVDYTMSSLFEYFMSMTLVPDLRNKKQIGYVVXXXXXXXXX 901
KE+ ++++Y ++ + ++ L M LR K+Q+GY+V
Sbjct: 744 KEEKNSAIMYNLQISQLDDERSGALTRLARQIMKEPTFSILRTKEQLGYIVFTLVRQVTP 803
Query: 902 XXXIHISVMSNLPPHTIEDRIEEYLYYLETNVLGAMTEAEFQDN-------ILQKYMQLI 954
++I V S +E RI L ++ L M++ +F + +L+K+ L
Sbjct: 804 FINLNIFVQSERSSTYLESRIRALLDQFKSEFL-EMSDEDFSKHKSSLINFMLEKHTNLK 862
Query: 955 KSNSL 959
+ +S+
Sbjct: 863 EESSM 867
>Hs4826770 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1019
Score = 133 bits (334), Expect = 2e-30
Identities = 103/412 (25%), Positives = 182/412 (44%), Gaps = 44/412 (10%)
Query: 15 TPISNSNRAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMI 74
T R ++ ++L+NGI LL+SDP +S V GS +DP + GL+H CEHM+
Sbjct: 55 TKSPEDKREYRGLELANGIKVLLMSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHML 114
Query: 75 ISSESKKFPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVIA 134
+KK+PK + Y L E+ G+ NAFT+GE T++YF++ + + + + A
Sbjct: 115 FLG-TKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEH-------LEGALDRFA 166
Query: 135 DKLGSPIFQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTL 194
P+F + ++E+ A+D+EHE N + L+ K + FS+F TGN YTL
Sbjct: 167 QFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTL 226
Query: 195 TQFPIVAGKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKST- 253
P G I+++ L K ++ + + +++ + G +SL L LV F + K+
Sbjct: 227 ETRPNQEG--IDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVP 284
Query: 254 ---IKSQSFSIESFKKLQKVWAARYTEPLFSKQEPETPNSILIQSSKAPILRLVFPVSHQ 310
F E K+L K+ + L+ + FP+
Sbjct: 285 LPEFPEHPFQEEHLKQLYKIVPIKDIRNLY----------------------VTFPIPDL 322
Query: 311 EALFSRSELKIFSKVWSDLFGDESSGSIHSKFSARNILTRQVTQLSKFTIDDEGLVLQFE 370
+ + + L G E GS+ S+ ++ + V + ++ +
Sbjct: 323 QKYYKSNP----GHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVD 378
Query: 371 LTNSGWKTGVESLLTDLFQGFLPFFQSIDPDEIAQYLNEWNTINLLQFMYQD 422
LT G VE ++ +FQ ++ ++ P E E +N + F ++D
Sbjct: 379 LTEEG-LLHVEDIILHMFQ-YIQKLRAEGPQE--WVFQECKDLNAVAFRFKD 426
Score = 68.6 bits (166), Expect = 6e-11
Identities = 94/463 (20%), Positives = 174/463 (37%), Gaps = 60/463 (12%)
Query: 594 PRLMSKNENYELWVKEENSLEYSSRSVITIELINMGMEPSAKNTMNLEILTQLLYFYINE 653
P L+ +LW K+++ + ++ + E + + + +LL +NE
Sbjct: 548 PALIKDTVMSKLWFKQDDKKK-KPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNE 606
Query: 654 SLYPSERVGYMYQIAANNRGDVRLAVTINGFPQGVAMILQIIMDKMV--DIGKPDFDITN 711
Y +E G Y + G + +++ G+ ++L+ I++KM +I + F+I
Sbjct: 607 YAYAAELAGLSYDLQNTIYG---MYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIK 663
Query: 712 SMFRHSRILVRTKYEEAARANSCTLASLGVXXXXXXXXXXXXXXXDALEDIDIESFKMFC 771
+ S R + L V +AL+D+ + K F
Sbjct: 664 EAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELK-------EALDDVTLPRLKAFI 716
Query: 772 KDLW----IPKSNYMNLVIQGDLSIAETVNQYMDGIIHHLSGPNVNQTSVFRLREPETIK 827
L I + N+ Q L I + V D +I H + + + R RE ++
Sbjct: 717 PQLLSRLHIEALLHGNITKQAALGIMQMVE---DTLIEHAHTKPLLPSQLVRYRE---VQ 770
Query: 828 LAQGSNFFIEMTSFKEDPTNSVVYFIETGDRTNPVDYTMSSLFEYFMSMTLVPDLRNKKQ 887
L F + + + +Y+ D + + LF +S LR K+Q
Sbjct: 771 LPDRGWFVYQQRNEVHNNCGIEIYY--QTDMQSTSENMFLELFCQIISEPCFNTLRTKEQ 828
Query: 888 IGYVVXXXXXXXXXXXXIHISVMSNLPPHTIEDRIEEYLYYLETNVLGAMTEAEFQDNIL 947
+GY+V + + S PPH +E R+E +L +E ++ MTE F
Sbjct: 829 LGYIVFSGPRRANGIQSLRFIIQSEKPPHYLESRVEAFLITMEKSI-EDMTEEAF----- 882
Query: 948 QKYMQLIKSNSLEKLIKNAGPANLMAQIEASVHSGNYPSNLQSQGYTVGQHKKLKDEISF 1007
QK++Q + L+K P L A+ K EI
Sbjct: 883 QKHIQALAIRRLDK------PKKLSAEC-----------------------AKYWGEIIS 913
Query: 1008 RTYAFSETKVDVCLLSKLTLQEFKRLFMEKISILSLQRRKLSV 1050
+ Y F +V L LT ++ + + E +++ + +R K+SV
Sbjct: 914 QQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSV 956
>At3g57470 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 989
Score = 131 bits (330), Expect = 5e-30
Identities = 206/976 (21%), Positives = 396/976 (40%), Gaps = 144/976 (14%)
Query: 22 RAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKK 81
R ++ + L N + LLISDP + +V+ GS DP+ + GLAH EHM+ + S+K
Sbjct: 25 REYRRIVLKNSLEVLLISDPETDKCAASMNVSVGSFTDPEGLEGLAHFLEHMLFYA-SEK 83
Query: 82 FPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSPI 141
+P+ Y + E+ G+ NA+T+ E T+++F+I + F E + A P+
Sbjct: 84 YPEEDSYSKYITEHGGSTNAYTSSEDTNYHFDINTDS-------FYEALDRFAQFFIQPL 136
Query: 142 FQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTLTQFPIVA 201
+ +EI+A+D+EH+NN S + K L+ + + +FSTGN+ TL P
Sbjct: 137 MSTDATMREIKAVDSEHQNNLLSDSWRMAQLQKHLSREDHPYHKFSTGNMDTLHVRPEEN 196
Query: 202 GKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKS----TIKSQ 257
G ++ ++ L K Y +++ A + +V+ G ++L + LV+ F R + Q
Sbjct: 197 G--VDTRSELIKFYDEHYSANIMHLVVYGKENLDKTQGLVEALFQGIRNTNQGIPRFPGQ 254
Query: 258 SFSIESFKKLQKVWAARYTEPLFSKQEPETPNSILIQSSKAPILRLVFPVSHQEALFSRS 317
+++ + L K L S P TP+ +SH E R
Sbjct: 255 PCTLDHLQVLVKAVPIMQGHEL-SVSWPVTPS-----------------ISHYEEAPCR- 295
Query: 318 ELKIFSKVWSDLFGDESSGSIHSKFSARNILTRQVTQLSKFTIDDEGLVLQFELTNSGWK 377
DL G E GS+ T + ++++ + +LT++G +
Sbjct: 296 -------YLGDLIGHEGEGSLFHALKILGWATGLYAGEADWSMEYSFFNVSIDLTDAGHE 348
Query: 378 TGVESLLTDLFQGFLPFFQSIDPDEIAQYL-NEWNTINLLQFMYQDLDNSTMDKCS---D 433
++ +L LF+ + + + ++Q++ +E + I +F YQ + +D S D
Sbjct: 349 -HMQDILGLLFE----YIKVLQQSGVSQWIFDELSAICEAEFHYQ----AKIDPISYAVD 399
Query: 434 LCSELLQCEDPQFILNNSIAFSCNRKGSDIGSYYESPKSKEWWNSQAKKFLSFVKTYMSW 493
+ S + +++ GS + S + ++ + + S S+
Sbjct: 400 ISSNMKIYPTKHWLV-----------GSSLPSKFNPAIVQKVLDELSPNNPSVPNVLCSY 448
Query: 494 NNCKLIFLGDLQSNDFLKSRQVPTNVKFDEHYRFQYELSLI---KLNHVKMSPKDFR--L 548
N + + + D L+ RQ K + Y Y L I + S D L
Sbjct: 449 N----LHVVQALNPDCLRPRQTD---KVEPWYNTAYSLEKITKFTIQEWMQSAPDVNLLL 501
Query: 549 PSSTAFL---FGLEKNLSALKQSLTAVLRKSQGSALSIITQSKLLQTTPRLMSKNENYEL 605
P+ F+ F L K+L K +LRK+ S L
Sbjct: 502 PTPNVFIPTDFSL-KDLKD-KDIFPVLLRKTSYS------------------------RL 535
Query: 606 WVKEENSLEYSSRSVITIELINMGMEPSAKNTMNL-EILTQLLYFYINE---------SL 655
W K + + ++ + ++ N + S+ + L +I LL Y+NE S
Sbjct: 536 WYKPDTKF-FKPKAYVKMD-FNCPLAVSSPDAAVLSDIFVWLLVDYLNEYALINLDYVSA 593
Query: 656 YPSERVGYMYQIAANNRGDVRLAVTINGFPQGVAMILQIIMDKMVDIG-KPD-FDITNSM 713
Y ++ G Y ++ ++ G +++ GF + ++L+ ++ K+ KPD F +
Sbjct: 594 YYAQAAGLDYGLSLSDNG---FELSLAGFNHKLRILLEAVIQKIAKFEVKPDRFSVIKET 650
Query: 714 FRHSRILVRTKYEEAARANSCTLASLGVXXXXXXXXXXXXXXXDALEDIDIESFKMFCKD 773
+ + + N C+L DAL ++ E F
Sbjct: 651 VTKAYQNNKFQQPHEQATNYCSLV-------LQDQIWPWTEELDALSHLEAEDLANFVPM 703
Query: 774 LWIPKSNYMNLVIQGDL--SIAETVNQYMDGIIHHLSGPNVNQTSVFRLREPETIKLAQG 831
L ++ I G++ AE++ ++++ ++ S P + +L G
Sbjct: 704 LL--SRTFVECYIAGNVEKDEAESMVKHIEDVLFTDSKPICRPLFPSQFLTNRVTELGTG 761
Query: 832 -SNFFIEMTSFKEDPTNSVVYFIETGDRTNPVDYTMSS---LFEYFMSMTLVPDLRNKKQ 887
+F+ + S D +++V++I+ + +++M+S LFE LR +Q
Sbjct: 762 MKHFYYQEGSNSSDENSALVHYIQ----VHKDEFSMNSKLQLFELIAKQDTFHQLRTIEQ 817
Query: 888 IGYVVXXXXXXXXXXXXIHISVMSNLP-PHTIEDRIEEYLYYLETNVLGAMTEAEFQDNI 946
+GY+ + + S++ P I+ R+E L LE+ M++ EF+ N+
Sbjct: 818 LGYITSLSLSNDSGVYGVQFIIQSSVKGPGHIDSRVESLLKDLESKFYN-MSDEEFKSNV 876
Query: 947 LQKY-MQLIKSNSLEK 961
M+L K +L++
Sbjct: 877 TNLIDMKLEKDKNLDE 892
>At2g41790 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 970
Score = 121 bits (304), Expect = 6e-27
Identities = 107/410 (26%), Positives = 188/410 (45%), Gaps = 52/410 (12%)
Query: 21 NRAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESK 80
NR ++ + L N + LLISDP + SV+ GS +DP + GLAH EHM+ + S+
Sbjct: 22 NREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGLEGLAHFLEHMLFYA-SE 80
Query: 81 KFPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSP 140
K+P+ Y + E+ G+ NA+T E+T+++F++ FDE + A P
Sbjct: 81 KYPEEDSYSKYITEHGGSTNAYTASEETNYHFDV-------NADCFDEALDRFAQFFIKP 133
Query: 141 IFQSADINKEIQAIDNEHENNKNLVSKA--LYHGTKKLATQRSKFSRFSTGNIYTLTQFP 198
+ + +EI+A+D+ EN KNL+S + K L+ + + +FSTGN+ TL P
Sbjct: 134 LMSADATMREIKAVDS--ENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNMDTLHVRP 191
Query: 199 IVAGKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKSTIKSQS 258
G ++ ++ L K Y +++ A + +V+ G +SL ++ LV+ F
Sbjct: 192 QAKG--VDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMF------------- 236
Query: 259 FSIESFKKLQKVWAARYTEPLFSKQEPETPNSILIQSSKAPI-----LRLVFPVSHQEAL 313
Q++ P F Q P T + + I PI L + +PV+
Sbjct: 237 ---------QEIQNTNKVVPRFPGQ-PCTADHLQILVKAIPIKQGHKLGVSWPVTPSIHH 286
Query: 314 FSRSELKIFSKVWSDLFGDESSGSIHSKFSARNILTRQVTQLSKFTIDDEGLVLQFELTN 373
+ + S+ L G E GS+ T ++T+D + +LT+
Sbjct: 287 YDEAP----SQYLGHLIGHEGEGSLFHALKTLGWATGLSAGEGEWTLDYSFFKVSIDLTD 342
Query: 374 SGWKTGVESLLTDLFQGFLPFFQSIDPDEIAQYL-NEWNTINLLQFMYQD 422
+G + ++ +L LF + Q + + Q++ +E + I +F YQD
Sbjct: 343 AGHE-HMQEILGLLFN----YIQLLQQTGVCQWIFDELSAICETKFHYQD 387
>YLR389c [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 988
Score = 117 bits (293), Expect = 1e-25
Identities = 70/226 (30%), Positives = 116/226 (50%), Gaps = 10/226 (4%)
Query: 22 RAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKK 81
R+++F++L N + ALLI DP A+ V G+ DP +PGLAH CEH++ S+K
Sbjct: 72 RSYRFIELPNKLKALLIQDPKADKAAASLDVNIGAFEDPKNLPGLAHFCEHLLFMG-SEK 130
Query: 82 FPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSPI 141
FP + Y L ++ G+ NA+T + T+++FE+ N++ D G + P+
Sbjct: 131 FPDENEYSSYLSKHGGSSNAYTASQNTNYFFEV---NHQHLFGALDRFSGFFS----CPL 183
Query: 142 FQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTLTQFPIVA 201
F +KEI A+++E++ N +Y K L + + +FSTGNI TL P
Sbjct: 184 FNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKEN 243
Query: 202 GKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGD 247
G +N+++ L K + + + A + + I G + L L F D
Sbjct: 244 G--LNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKD 287
Score = 52.4 bits (124), Expect = 4e-06
Identities = 97/456 (21%), Positives = 178/456 (38%), Gaps = 38/456 (8%)
Query: 594 PRLMSKNENYELWVKEENSLEYSSRSVITIELINMGMEPSAKNTMNLEILTQLLYFYINE 653
P L+ ++ +LW K+++ + R I + S N+M + TQL + +
Sbjct: 558 PVLLLSDDVSKLWYKKDDRF-WQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKD 616
Query: 654 SLYPSERVGYMYQIAANNRGDVRLAVTINGFPQGVAMILQIIMDKM--VDIGKPDFDIT- 710
Y + N+G LA+T +GF + + ++L + + + K F+I
Sbjct: 617 VQYDAACADLRISFNKTNQG---LAITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILK 673
Query: 711 NSMFRHSR-ILVRTKYEEAARANSCTLASLGVXXXXXXXXXXXXXXXDALEDIDIESFKM 769
+ RH + +L Y + + + + E + E
Sbjct: 674 DKTIRHLKNLLYEVPYSQMSNYYNAIINE---------RSWSTAEKLQVFEKLTFEQLIN 724
Query: 770 FCKDLWIPKSNYMNLVIQGDLSIAETVNQYMDGIIHHLSGPNVN--QTSVFRLREPETIK 827
F ++ + Y +I G++ E + +D +I L N++ Q S RLR +
Sbjct: 725 FIPTIY--EGVYFETLIHGNIKHEEALE--VDSLIKSLIPNNIHNLQVSNNRLR---SYL 777
Query: 828 LAQGSNFFIEMTSFKEDPTNSVVYFIETGDRTNPVDYTMSSLFEYFMSMTLVPDLRNKKQ 887
L +G F E NS + + D + +S LF + LR K+Q
Sbjct: 778 LPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALSGLFAQLIHEPCFDTLRTKEQ 837
Query: 888 IGYVVXXXXXXXXXXXXIHISVMSNLPPHTIEDRIEEYLYYLETNVLGAMTEAEFQDNIL 947
+GYVV I I + S +E RI + Y VL M E +F
Sbjct: 838 LGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNF-YETFGQVLRDMPEEDF----- 891
Query: 948 QKYMQLIKSNSLEKLIKNAGPANLMAQIEASVHSGNYP-SNLQSQGYTVGQHKKLKDEIS 1006
+K+ + + NSL + KN A A+ A+++ G+Y ++ Q + V K +
Sbjct: 892 EKHKEAL-CNSLLQKFKNM--AEESARYTAAIYLGDYNFTHRQKKAKLVANITKQQMIDF 948
Query: 1007 FRTYAFSE--TKVDVCLLSKLTLQEFKRLFMEKISI 1040
+ Y SE +K+ + L S++ + ++ +SI
Sbjct: 949 YENYIMSENASKLILHLKSQVETKSSMKMNWTPLSI 984
>7296294 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 990
Score = 107 bits (266), Expect = 1e-22
Identities = 67/231 (29%), Positives = 114/231 (49%), Gaps = 10/231 (4%)
Query: 22 RAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKK 81
R ++ +QL NG+ LLISDP ++ SV G +DP +PGLAH CEHM+ ++K
Sbjct: 35 RDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFLG-TEK 93
Query: 82 FPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSPI 141
+P + Y L + G+ NA T T ++F + D + A +P+
Sbjct: 94 YPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDK-------LDGALDRFAQFFIAPL 146
Query: 142 FQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTLTQFPIVA 201
F + +EI A+++EHE N + + LA +S+F +GN TL++ P
Sbjct: 147 FTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIP--K 204
Query: 202 GKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKS 252
K I++++ L K + + A + + + G +SL L+ +V F + K+
Sbjct: 205 SKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKN 255
Score = 68.6 bits (166), Expect = 6e-11
Identities = 99/472 (20%), Positives = 179/472 (36%), Gaps = 63/472 (13%)
Query: 594 PRLMSKNENYELWVKEENSLEYSSRSVITIELINMGMEPSAKNTMNLEILTQLLYFYINE 653
P ++ +W K++N ++ +T ++ N N ++ LL +NE
Sbjct: 521 PTIILDTPILRVWHKQDNQFN-KPKACMTFDMSNPIAYLDPLNCNLNHMMVMLLKDQLNE 579
Query: 654 SLYPSERVGYMYQIAANNRGDVRLAVTINGFPQGVAMILQIIMDKMVD--IGKPDFDITN 711
LY +E + + G + TI GF ++L+ ++D + D I + FDI
Sbjct: 580 YLYDAELASLKLSVMGKSCG---IDFTIRGFSDKQVVLLEKLLDHLFDFSIDEKRFDILK 636
Query: 712 SMFRHSRILVRTKYEEAARANSCTLASLGVXXXXXXXXXXXXXXXDALEDIDIESFKMFC 771
+ R L K E+ + + LA L DA+E + + F
Sbjct: 637 E--EYVRSLKNFKAEQPYQHSIYYLALL-----LTENAWANMELLDAMELVTYDRVLNFA 689
Query: 772 KDLWIPKSN----YMNLVIQGDLSIAETVNQYMDGIIHHLSGPNVNQTSVF--RLREPET 825
K+ + + N+ Q IA VN L N ++ + ++ +
Sbjct: 690 KEFFQRLHTECFIFGNVTKQQATDIAGRVNT-------RLEATNASKLPILARQMLKKRE 742
Query: 826 IKLAQGSNFFIEMTSFKEDPTNSVVYFIETGDRTNPVDYTMSSLFEYFMSMTLVPDLRNK 885
KL G ++ E + + + +Y ++ G +T+ + M +L +S LR K
Sbjct: 743 YKLLAGDSYLFEKENEFHKSSCAQLY-LQCGAQTDHTNI-MVNLVSQVLSEPCYDCLRTK 800
Query: 886 KQIGYVVXXXXXXXXXXXXIHISVMSNLPPHTIEDRIEEYLYYLETNVLGAMTEAEFQDN 945
+Q+GY+V I I V S P +EDRIE N
Sbjct: 801 EQLGYIVFSGVRKVNGANGIRIIVQSAKHPSYVEDRIE---------------------N 839
Query: 946 ILQKYMQLIKSNSLEKLIKNAGPANLMAQIEASVHSGNYPSNLQSQGYTVGQHKKLKDEI 1005
LQ Y+Q+I+ L++ ++ + L+ Q + EI
Sbjct: 840 FLQTYLQVIEDMPLDEFERHKEALAV--------------KKLEKPKTIFQQFSQFYGEI 885
Query: 1006 SFRTYAFSETKVDVCLLSKLTLQEFKRLFMEKISILSLQRRKLSVRFKTPMT 1057
+ +TY F + +V +L K++ +F F + I+ +RR LSV + T
Sbjct: 886 AMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRVLSVHIVSQQT 937
>ECU06g0750 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 882
Score = 106 bits (265), Expect = 2e-22
Identities = 65/218 (29%), Positives = 112/218 (50%), Gaps = 16/218 (7%)
Query: 24 HQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKKFP 83
+++V++ NG+ AL++SDPG S SV GS +DP + GLAH EHM+ ++K+P
Sbjct: 27 YEYVEIPNGMRALIMSDPGLDKCSCAVSVRVGSFDDPADAQGLAHFLEHMLFMG-TEKYP 85
Query: 84 KRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSPIFQ 143
L + NG NA T GE T +YF++ F+E V + AD SP+ +
Sbjct: 86 VEDGLSYFLSKNNGGYNATTYGEATVYYFDV-------RPEAFEEAVDMFADFFKSPLLK 138
Query: 144 SADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTLTQFPIVAGK 203
+ +E+ A+++E N N + KK + S+FSTGN TL +
Sbjct: 139 RDSVEREVSAVNSEFCNGLNNDGWRTWRMMKKCCKKEQALSKFSTGNYDTLRR------- 191
Query: 204 IINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLV 241
+ +++ ++ + ++ + +VI G++S LK+L+
Sbjct: 192 -DGIWEEMKEFWSRKYSSDKMCVVIYGNKSPGELKELL 228
>CE06755 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 980
Score = 102 bits (255), Expect = 3e-21
Identities = 74/257 (28%), Positives = 126/257 (48%), Gaps = 28/257 (10%)
Query: 18 SNSNRAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISS 77
+ +R ++ ++L+NGI LL+SDP ++ V G DP E+PGLAH CEHM+
Sbjct: 20 AQDDREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHMLFLG 79
Query: 78 ESKKFPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVI---A 134
+ K+P + Y L + G++NA T + T+++F++ KP D+L G +
Sbjct: 80 -TAKYPTENEYSKFLTDNAGHRNAVTASDHTNYHFDV--------KP--DQLRGALDRFV 128
Query: 135 DKLGSPIFQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTL 194
SP F + +E+ A+D+EH NN N L + L+ +++F TGN TL
Sbjct: 129 QFFLSPQFTESATEREVCAVDSEHSNNLNNDLWRLSQVDRSLSKPGHDYAKFGTGNKKTL 188
Query: 195 TQFPIVAGKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKSTI 254
+ G + ++ L + Y + + ++ I G +SL L+ ++T D
Sbjct: 189 LEEARKKG--VEPRDALLQFYKKWYSSNIMTCCIIGKESLDVLQSHLKTLEFD------- 239
Query: 255 KSQSFSIESFKKLQKVW 271
+IE+ K +KVW
Sbjct: 240 -----TIENKKVERKVW 251
>CE10402 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1067
Score = 99.8 bits (247), Expect = 2e-20
Identities = 98/409 (23%), Positives = 175/409 (41%), Gaps = 51/409 (12%)
Query: 22 RAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKK 81
R ++ ++L+NGI LL+SDP ++ V G DP E+PGLAH CEHM+ + K
Sbjct: 83 REYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHMLFLG-TAK 141
Query: 82 FPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVI---ADKLG 138
+P + Y L + G+ NA+T+ + T+++F++ KP D+L G +
Sbjct: 142 YPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDV--------KP--DQLPGALDRFVQFFL 191
Query: 139 SPIFQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTLTQFP 198
SP F + +E+ A+D+EH NN N + + + +F TGN TL +
Sbjct: 192 SPQFTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDA 251
Query: 199 IVAGKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKSTIKSQS 258
G I ++ L + + + ++ ++ I G + L+ L+ + T D
Sbjct: 252 RKKG--IEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFD----------- 298
Query: 259 FSIESFKKLQKVWAARYTEPLFSKQEPETPNSILIQSSKAPILRLVFPVSHQEALFSRSE 318
+IE+ K +KVW P Q + + + I+ ++ + FP + E L
Sbjct: 299 -AIENKKVERKVWE---EFPYGPDQLAKRIDVVPIKDTRLVSISFPFPDLNGEFLSQPGH 354
Query: 319 LKIFSKVWSDLFGDESSGSIHSKFSARNILTRQVTQLSKFTIDDEGLVLQFELTNSGWKT 378
S L G E GS+ S+ +++ +S D F + N
Sbjct: 355 ------YISHLIGHEGPGSLLSEL-------KRLGWVSSLQSDSHTQAAGFGVYNVTMDL 401
Query: 379 GVESL-----LTDLFQGFLPFFQSIDPDEIAQYLNEWNTINLLQFMYQD 422
E L + L ++ QS P + +E ++ ++F ++D
Sbjct: 402 STEGLEHVDEIIQLMFNYIGMLQSAGPKQWVH--DELAELSAVKFRFKD 448
>CE01818 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 745
Score = 93.2 bits (230), Expect = 2e-18
Identities = 95/413 (23%), Positives = 179/413 (43%), Gaps = 51/413 (12%)
Query: 18 SNSNRAHQFVQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISS 77
S + ++ ++L+NG+ LL+SD +++ V G DP E+PGLAH CEHM+
Sbjct: 21 SQDTKKYRGLELTNGLRVLLVSDSKTRVSAVALDVKVGHLMDPWELPGLAHFCEHMLFLG 80
Query: 78 ESKKFPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVI---A 134
+ K+P Y L NG+ NA+T + T++ FE+ + ++L G + A
Sbjct: 81 -TAKYPSEREYFKYLAANNGDSNAYTDTDHTNYSFEVRS----------EKLYGALDRFA 129
Query: 135 DKLGSPIFQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTL 194
P F + +E+ A++ E+ + N + L+ +S+F+ GN TL
Sbjct: 130 QFFLDPQFTESATEREVCAVNCEYLDKVNEDFWRCLQVERSLSKPGHDYSKFAIGNKKTL 189
Query: 195 TQFPIVAGKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKSTI 254
+ P G I ++VL Y + + ++ ++ I G +SL L ++ G F+
Sbjct: 190 LEDPRTKG--IEPRDVLLDFYKNWYSSDIMTCCIVGKESLDVL----ESYLGSFKFD--- 240
Query: 255 KSQSFSIESFKKLQKVWAARYTEPLFSKQEPETPNSILIQSSKAPILRLVFPVSHQEALF 314
+I++ +K +K+W P Q + + IQ++ ++ FP + E L
Sbjct: 241 -----AIKNTRKERKIWK---DSPFGPDQLAKRIEIVPIQNTGQVSIKFPFPDLNGEFLS 292
Query: 315 SRSELKIFSKVWSDLFGDESSGSIHSKFSARNILTRQVTQLSKFTIDDEGLVLQFELTNS 374
+ + L G E GS+ S+ +++ + D+ + F + +
Sbjct: 293 QPGD------YIAHLIGHEGPGSLLSEL-------KRLGWVISLEADNHTIASGFGVFSV 339
Query: 375 GWKTGVESL--LTDLFQ---GFLPFFQSIDPDEIAQYLNEWNTINLLQFMYQD 422
E L + D+ Q F+ F +S P + +E +N + F + D
Sbjct: 340 TMDLSTEGLEHVDDVIQLVFNFIGFLKSSGPQKWIH--DELAELNAVDFRFDD 390
>CE06756 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 845
Score = 90.1 bits (222), Expect = 2e-17
Identities = 85/319 (26%), Positives = 142/319 (43%), Gaps = 39/319 (12%)
Query: 27 VQLSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKKFPKRS 86
++L+NG+ LL+SDP +++ +V G DP E+PGLAH CEHM+ S K+P +
Sbjct: 29 LELTNGLRVLLVSDPTTDKSAVSLAVKAGHLMDPWELPGLAHFCEHMLFLGTS-KYPLEN 87
Query: 87 HYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVI---ADKLGSPIFQ 143
+ L + G+ NA T + T ++F++ KP D+L G + P F
Sbjct: 88 EFTKFLSDNAGSYNACTEPDHTYYHFDV--------KP--DQLYGALDRFVQFFLCPQFT 137
Query: 144 SADINKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTLTQFPIVAGK 203
+ +E+ A+D+EH +N N + + L+ +F TGN TL + G
Sbjct: 138 KSATEREVCAVDSEHLSNLNSDYWRILQVDRSLSRPGHDNRKFCTGNKKTLLEDARKKG- 196
Query: 204 IINLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKSTIKSQSFSIES 263
I ++ L + Y + + ++ I G +SL L+ ++T D +I++
Sbjct: 197 -IEPRDALLEFYKKWYSSNIMTCCIIGKESLDVLESYLRTLEFD------------AIQN 243
Query: 264 FKKLQKVWAA-RYTEPLFSKQEPETPNSILIQSSKAPILRLVFPVSHQEALFSRSELKIF 322
K KVWA +Y +K+ P I+ K + FP + E L
Sbjct: 244 KKAESKVWAEFQYGPDQLAKKIDVVP----IKDKKLVSIIFPFPDLNNEYLSQPGH---- 295
Query: 323 SKVWSDLFGDESSGSIHSK 341
+ L G + GSI S+
Sbjct: 296 --YIAHLIGHKGPGSISSE 312
>At1g06900 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1023
Score = 81.6 bits (200), Expect = 6e-15
Identities = 178/864 (20%), Positives = 328/864 (37%), Gaps = 129/864 (14%)
Query: 46 ASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKKFPKRSHYHDLLIEYNGNQNAFTTG 105
A++C S+ GS DP E GLAH EHM+ S +FP + Y L ++ G+ NA+T
Sbjct: 109 AAMCVSM--GSFLDPPEAQGLAHFLEHMLFMG-STEFPDENEYDSYLSKHGGSSNAYTEM 165
Query: 106 EQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSPIFQSADINKEIQAIDNEHENNKNLV 165
E T ++FE+ + F + +P+ ++ + +E+ A+D+E
Sbjct: 166 EHTCYHFEVKREFLQGALKRFSQF-------FVAPLMKTEAMEREVLAVDSEFNQALQND 218
Query: 166 SKALYHGTKKLATQRSKFSRFSTGNIYTLTQFPIVAGKIINLKNVLQKHYADNFVAENIS 225
+ L + + F+RF+ G + + G ++L+ + K Y + + +
Sbjct: 219 ACRLQQLQCYTSAKGHPFNRFAWGKDTAVLSGAMENG--VDLRECIVKLYKEYYHGGLMK 276
Query: 226 IVIRGSQSLHYLKKLVQTTFGDFRTKSTIKSQSFSIESFKKLQKVWAARYTEPLFSKQEP 285
+V+ G +SL L+ V FGD + S I+ + K K++ + E
Sbjct: 277 LVVIGGESLDMLESWVVELFGDVKNGSKIRPTLEAEGPIWKGGKLY----------RLEA 326
Query: 286 ETPNSILIQSSKAPILRLVFPVSHQEALFSRSELKIFSKVWSDLFGDESSGSIHSKFSAR 345
IL + P LR + ++ L + L G E GS+HS A+
Sbjct: 327 VKDVHILDLTWTLPPLRSAYVKKPEDYL-------------AHLLGHEGRGSLHSFLKAK 373
Query: 346 NILTRQVTQLSKFTIDDEGLVLQF----ELTNSGWKTGVESLLTDLFQGFLPFFQSIDPD 401
T + I+ L F LT+SG + + ++ ++Q +L + + P
Sbjct: 374 GWATSLSAGVGDDGINRSSLAYVFGMSIHLTDSGLEK-IYDIIGYIYQ-YLKLLRDVSPQ 431
Query: 402 EIAQYLNEWNTINLLQFMYQDLDNSTMDKCSDLCSELLQCEDPQFILNNSIAFSCNRKGS 461
E E I + F + + + D ++L +L I + +
Sbjct: 432 E--WIFKELQDIGNMDFRFAE-EQPADDYAAELSENMLAYPVEHVIYGDYV--------- 479
Query: 462 DIGSYYESPKSKEWWNSQAKKFLSFVKTYMSWNNCKLIFLGDLQSNDFLKSRQVPTNVKF 521
Y++ W+ K + + + + N ++ D+ S +KS + F
Sbjct: 480 -----YQT------WD---PKLIEDLMGFFTPQNMRI----DVVSKS-IKSEEFQQEPWF 520
Query: 522 DEHY-RFQYELSLIK-LNHVKMSPKDFRLPSSTAFLFGLEKNLSALKQSLTAVLRKSQGS 579
Y LSL++ ++ LPS F+ + ++ A+ + KSQ
Sbjct: 521 GSSYIEEDVPLSLMESWSNPSEVDNSLHLPSKNQFI-PCDFSIRAINSDVDP---KSQ-- 574
Query: 580 ALSIITQSKLLQTTPRLMSKNENYELWVKEENSLEYSSRSVITIELINM-GMEPSAKNTM 638
+ PR + + W K + + + + T IN+ G S KN +
Sbjct: 575 ------------SPPRCIIDEPFMKFWYKLDETFKVPRAN--TYFRINLKGAYASVKNCL 620
Query: 639 NLEILTQLLYFYINESLYPSERVGYMYQIAANNRGDVRLAVTINGFPQGVAMILQIIMDK 698
E+ LL +NE +Y + ++ + + + GD +L + + GF + + +L K
Sbjct: 621 LTELYINLLKDELNEIIYQATKL----ETSLSMYGD-KLELKVYGFNEKIPALL----SK 671
Query: 699 MVDIGKPDFDITNSMFRHSRILVRTKYEEAAR------ANSCTLASLGVXXXXXXXXXXX 752
++ I K F F+ +++ E R N T L +
Sbjct: 672 ILAIAK-SFMPNLERFK----VIKENMERGFRNTNMKPLNHSTYLRLQL---LCKRIYDS 723
Query: 753 XXXXDALEDIDIESFKMFCKDLWIPKSNYMNLVIQGDLSIAETVNQYMDGIIHHLSGPNV 812
L D+ ++ F +L ++ + G+LS E VN I +
Sbjct: 724 DEKLSVLNDLSLDDLNSFIPEL--RSQIFIEALCHGNLSEDEAVN-----ISNIFKDSLT 776
Query: 813 NQTSVFRLREPETIK-LAQGSNFFIEMTSFKEDPTNSVV---YFIETGDRTNPVDYTMSS 868
+ + R E I G+ ++ + TNSVV Y IE + + +
Sbjct: 777 VEPLPSKCRHGEQITCFPMGAKLVRDVNVKNKSETNSVVELYYQIEPEEAQSTRTKAVLD 836
Query: 869 LFEYFMSMTLVPDLRNKKQIGYVV 892
LF + L LR K+Q+GYVV
Sbjct: 837 LFHEIIEEPLFNQLRTKEQLGYVV 860
>7296373 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 908
Score = 80.5 bits (197), Expect = 1e-14
Identities = 75/289 (25%), Positives = 125/289 (42%), Gaps = 40/289 (13%)
Query: 21 NRAHQFVQLSNGITALLISDP------------------GESF----ASLCASVATGSHN 58
++ ++ + LSNG+ A+LISD E+F A+ V GS +
Sbjct: 47 SKLYRALTLSNGLRAMLISDSYIDEPSIHRASRESLNSSTENFNGKLAACAVLVGVGSFS 106
Query: 59 DPDEVPGLAHLCEHMIISSESKKFPKRSHYHDLLIEYNGNQNAFTTGEQTSFYFEIPNSN 118
+P + GLAH EHMI S+KFP + + + + G NA T E+T FYFE+ ++
Sbjct: 107 EPQQYQGLAHFVEHMIFMG-SEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFELDQTH 165
Query: 119 NKTGKPIFDELVGVIADKLGSPIFQSADINKEIQAIDNEHENNKNLVSKALYHGTKKLAT 178
G +F L + +P+ +++E A+ +E E LA+
Sbjct: 166 LDRGMDLFMNL-------MKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLAS 218
Query: 179 QRSKFSRFSTGNIYTLTQFPIVAGKIINLKNVLQKHYADNFVAENISIVIRGSQSLHYLK 238
+ FS GN TL + +L L K Y D++ + + + ++ SL L+
Sbjct: 219 EGYPHGTFSWGNYKTLKE----GVDDSSLHKELHKFYRDHYGSNRMVVALQAQLSLDELE 274
Query: 239 KLVQTTFGDFRTKSTIKSQSFSIE-SFKKLQKVWAARYTEPLFSKQEPE 286
+L+ D T SQ SI+ S QK + ++ + +F Q E
Sbjct: 275 ELLVRHCADIPT-----SQQNSIDVSQLNYQKAFRDQFYKDVFLVQPVE 318
>Hs4505453 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1219
Score = 73.6 bits (179), Expect = 2e-12
Identities = 62/235 (26%), Positives = 108/235 (45%), Gaps = 22/235 (9%)
Query: 44 SFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKKFPKRSHYHDLLIEYNGNQNAFT 103
S A+LC V GS DPD++PGLAH EHM+ S K+P + + L ++ G+ NA T
Sbjct: 279 SAAALCVGV--GSFADPDDLPGLAHFLEHMVFMG-SLKYPDENGFDAFLKKHGGSDNAST 335
Query: 104 TGEQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSPIFQSADINKEIQAIDNEHE--NN 161
E+T F F++ + F E + A P+ I++E++A+D+E++
Sbjct: 336 DCERTVFQFDVQ-------RKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARP 388
Query: 162 KNLVSKALYHGTKKLATQRSKFSRFSTGNIYTLTQFPIVAGKIINLKNVLQKHYADNFVA 221
+ K + G+ LA +F GN TL P I+ L++ + + +
Sbjct: 389 SDANRKEMLFGS--LARPGHPMGKFFWGNAETLKHEP--RKNNIDTHARLREFWMRYYSS 444
Query: 222 ENISIVIRGSQSLHYLKKLVQTTFGDFRTKSTIK------SQSFSIESFKKLQKV 270
+++V++ ++L L+K V F + + F +F KL +V
Sbjct: 445 HYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRV 499
Score = 58.5 bits (140), Expect = 6e-08
Identities = 62/339 (18%), Positives = 138/339 (40%), Gaps = 19/339 (5%)
Query: 605 LWVKEENSLEYSSRSVITIELINMGMEPSAKNTMNLEILTQLLYFYINESLYPSERVGYM 664
LW K++N + ++ I LI+ ++ SA N + +I +L + E Y ++
Sbjct: 759 LWYKKDNKFKIP-KAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLE 817
Query: 665 YQIAANNRGDVRLAVTINGFPQGVAMILQIIMDKMVDIGKPDFDITNSMFRHSRILVRTK 724
Y++AA G L + + GF + ++ Q+I+D + +F+ T ++F ++
Sbjct: 818 YKLAAGEHG---LIIRVKGFNHKLPLLFQLIIDYLA-----EFNSTPAVFTMITEQLKKT 869
Query: 725 YEEAARANSCTLASLGVXXXXXXXXXXXXXXXDALEDIDIESFKMFCKDLWIPKSNYMNL 784
Y + + ++ + +ES F K+ ++
Sbjct: 870 YFNILIKPETLAKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKE--FKSQLFVEG 927
Query: 785 VIQGDLSIAETVNQYMDGIIHHLSGPNVNQTSVFRLREPETIKLAQGSNFFIEMTSFKED 844
++QG+++ E+++ ++ ++ L+ + Q + + ++L G + K D
Sbjct: 928 LVQGNVTSTESMD-FLKYVVDKLNFKPLEQEMPVQF---QVVELPSGHHLCKVKALNKGD 983
Query: 845 PTNSVVYFIETGDRTNPVDYTMSSLFEYFMSMTLVPDLRNKKQIGYVVXXXXXXXXXXXX 904
+ V + ++G R+ +YT+ L M LR K+ +GY V
Sbjct: 984 ANSEVTVYYQSGTRSLR-EYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILG 1042
Query: 905 IHISVMSNLPPH---TIEDRIEEYLYYLETNVLGAMTEA 940
++V + + ++ +IEE+L E + EA
Sbjct: 1043 FSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEA 1081
>At3g02090 [O] KOG0960 Mitochondrial processing peptidase beta subunit and
related enzymes (insulinase superfamily)
Length = 531
Score = 61.2 bits (147), Expect = 9e-09
Identities = 52/229 (22%), Positives = 101/229 (43%), Gaps = 20/229 (8%)
Query: 29 LSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKKFPKRSHY 88
L NG+ S+ A++ + GS + DE G AH EHMI ++ +
Sbjct: 102 LPNGLRVATESNLSAKTATVGVWIDAGSRFESDETNGTAHFLEHMIFKGTDRRTVRA--L 159
Query: 89 HDLLIEYNGNQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSPIFQSADIN 148
+ + + G+ NA+T+ EQT++Y ++ +SN ++ + V+AD L + F+ IN
Sbjct: 160 EEEIEDIGGHLNAYTSREQTTYYAKVLDSN-------VNQALDVLADILQNSKFEEQRIN 212
Query: 149 KEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTG---NIYTLTQFPIVAGKII 205
+E I E + + + + A Q + R G N+ ++T+
Sbjct: 213 RERDVILREMQEVEGQTDEVVLDHLHATAFQYTPLGRTILGPAQNVKSITR--------E 264
Query: 206 NLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKSTI 254
+L+N ++ HY + + + ++ + + +KKL D T S +
Sbjct: 265 DLQNYIKTHYTASRMVIAAAGAVKHEEVVEQVKKLFTKLSSDPTTTSQL 313
>7292708 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1077
Score = 58.5 bits (140), Expect = 6e-08
Identities = 58/243 (23%), Positives = 105/243 (42%), Gaps = 17/243 (6%)
Query: 39 SDPGESFASLCASVAT-GSHNDPDEVPGLAHLCEHMIISSESKKFPKRSHYHDLLIEYNG 97
S+ G+ + CA + GS +P + GLAH EHMI S+K+PK + + + + G
Sbjct: 86 SEEGDEKLAACALLIDYGSFAEPTKYQGLAHFLEHMIFMG-SEKYPKENIFDAHIKKCGG 144
Query: 98 NQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSPIFQSADINKEIQAIDNE 157
NA T E T FYFE+ + + F L + +P+ + + +E A+D+E
Sbjct: 145 FANANTDCEDTLFYFEVAEKHLDSSLDYFTAL-------MKAPLMKQEAMQRERSAVDSE 197
Query: 158 HENNKNLVSKALYHGTKKLATQRSKFSRFSTGNIYTLTQFPIVAGKIINLKNVLQKHYAD 217
+ LAT+ F+ GN+ +L + A L +L + +
Sbjct: 198 FQQILQDDETRRDQLLASLATKGFPHGTFAWGNMKSLKENVDDA----ELHKILHEIRKE 253
Query: 218 NFVAENISIVIRGSQSLHYLKKLVQTTFGDFRTKSTIKSQSFSIESFKKLQKVWAARYTE 277
++ A + + ++ + L+ LV F + +K+ S ++K K A + E
Sbjct: 254 HYGANRMYVCLQARLPIDELESLVVRHFSGI-PHNEVKAPDLSSFNYKDAFK---AEFHE 309
Query: 278 PLF 280
+F
Sbjct: 310 QVF 312
>SPBP23A10.15c [O] KOG0960 Mitochondrial processing peptidase beta subunit and
related enzymes (insulinase superfamily)
Length = 457
Score = 53.1 bits (126), Expect = 2e-06
Identities = 56/222 (25%), Positives = 87/222 (38%), Gaps = 26/222 (11%)
Query: 29 LSNGITALLISDPGESFASLCASVATGSHNDPDEVPGLAHLCEHMIISSESKKFPKRSHY 88
L NG+T P A++ V GS + + G AH EH+ + K
Sbjct: 27 LKNGLTVATEHHPYAQTATVLVGVDAGSRAETAKNNGAAHFLEHLAFKGTKNRSQKAL-- 84
Query: 89 HDLLIEYNG-NQNAFTTGEQTSFYFEIPNSNNKTGKPIFDELVGVIADKLGSPIFQSADI 147
+L E G + NA+T+ EQT +Y K V V+AD L + ++ +
Sbjct: 85 -ELEFENTGAHLNAYTSREQTVYYAH-------AFKNAVPNAVAVLADILTNSSISASAV 136
Query: 148 NKEIQAIDNEHENNKNLVSKALYHGTKKLATQRSKFSRFSTG---NIYTLTQFPIVAGKI 204
+E Q I E E + + ++ A Q R G NI +LT
Sbjct: 137 ERERQVILREQEEVDKMADEVVFDHLHATAYQGHPLGRTILGPKENIESLT--------- 187
Query: 205 INLKNVLQKHYADNFVAENISIVIRGSQSLHYLKKLVQTTFG 246
+ L ++ DN+ ++ + I GS S L KL + FG
Sbjct: 188 ---REDLLQYIKDNYRSDRMIISSAGSISHEELVKLAEKYFG 226
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.133 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,152,120
Number of Sequences: 60738
Number of extensions: 2670077
Number of successful extensions: 6852
Number of sequences better than 1.0e-05: 18
Number of HSP's better than 0.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 6772
Number of HSP's gapped (non-prelim): 41
length of query: 1170
length of database: 30,389,216
effective HSP length: 118
effective length of query: 1052
effective length of database: 23,222,132
effective search space: 24429682864
effective search space used: 24429682864
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)