ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV3939 good S KOG0296 Function unknown Angio-associated migratory cell protein (contains WD40 repeats)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV3939 1334131 1335423 431
(431 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIR012w [S] KOG0296 Angio-associated migratory cell protein (con... 565 e-161
SPAC25H1.08c [S] KOG0296 Angio-associated migratory cell protein... 124 3e-28
Hs4557229 [S] KOG0296 Angio-associated migratory cell protein (c... 108 1e-23
At1g71840 [S] KOG0296 Angio-associated migratory cell protein (c... 94 5e-19
7294340 [S] KOG0296 Angio-associated migratory cell protein (con... 84 5e-16
CE26629 [S] KOG0296 Angio-associated migratory cell protein (con... 54 3e-07
>YIR012w [S] KOG0296 Angio-associated migratory cell protein (contains WD40
repeats)
Length = 431
Score = 565 bits (1455), Expect = e-161
Identities = 284/434 (65%), Positives = 336/434 (76%), Gaps = 22/434 (5%)
Query: 13 PEEEFIADEEVGEEVVLDNVEPSENI-----GDDDDNDQEMGGLDGAETLEIDMSNNSSG 67
P+EEFI EEV +E+V VE +++ G++DD+D+ M D E LE+DMSNNS
Sbjct: 3 PQEEFITTEEVEQEIV-PTVEVEQDVPVDIEGENDDDDEMMN--DDEEALEVDMSNNSLT 59
Query: 68 FFDKHTDSIFCIAHHPTLPLVMTGGADNVANLWTSHSKPPKFAGSLE-HTESVISGGFTP 126
+FDKHTDS+F I HHP LPLV TGG DN+A+LWTSHS+PPKFAG+L + ESVIS FT
Sbjct: 60 YFDKHTDSVFAIGHHPNLPLVCTGGGDNLAHLWTSHSQPPKFAGTLTGYGESVISCSFTS 119
Query: 127 DGKFLITADMNGKVFIHKSVKGGAQWKRCSXXXXXXXXXWLKVHPTVSGVFAFGGVDGSV 186
+G FL+TADM+GKV +H KGGAQWK S WLK HPT++ FAFG DGSV
Sbjct: 120 EGGFLVTADMSGKVLVHMGQKGGAQWKLASQMQEVEEIVWLKTHPTIARTFAFGATDGSV 179
Query: 187 WCYQLNNVDGSLSQIMSGFSHQQDCTMGEFINVEEGENNLTLVTCSLDSSIVAWNCYMGQ 246
WCYQ+N DGSL Q+MSGF HQQDC+MGEFIN ++GEN L LVTCSLDS+IVAWNC+ GQ
Sbjct: 180 WCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENTLELVTCSLDSTIVAWNCFTGQ 239
Query: 247 PLFKITQADIKGLEAPWVSLSAAPASLT-NNTAVIAAGSNNGLLAIINCSN-GSVLHLTT 304
LFKITQA+IKGLEAPW+SLS AP +LT N+ V+A GSNNGLLA+INC+N G++LHL+T
Sbjct: 240 QLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGSNNGLLAVINCNNGGAILHLST 299
Query: 305 VIELKPEQDELDASIESITWSSKLPLMAIGLVCGDALLYDTKTWRVRHKFQLEDSATKLQ 364
VIELKPEQDELDASIESI+WSSK LMAIGLVCG+ LLYDT WRVRHKF LEDS TKL
Sbjct: 300 VIELKPEQDELDASIESISWSSKFSLMAIGLVCGEILLYDTSAWRVRHKFVLEDSVTKLM 359
Query: 365 FDTINGHNLIASCINGKVYIFDARTGQEVHVCVGHNMGVLDFVVI--------ENGSKLI 416
FD +L ASCINGKVY F+ARTGQE VCVGHNMGVLDF+++ E K+I
Sbjct: 360 FD---NDDLFASCINGKVYQFNARTGQEKFVCVGHNMGVLDFILLHPVANTGTEQKRKVI 416
Query: 417 TAGDEGVSLIFDLP 430
TAGDEGVSL+F++P
Sbjct: 417 TAGDEGVSLVFEVP 430
>SPAC25H1.08c [S] KOG0296 Angio-associated migratory cell protein (contains WD40
repeats)
Length = 399
Score = 124 bits (311), Expect = 3e-28
Identities = 110/422 (26%), Positives = 200/422 (47%), Gaps = 40/422 (9%)
Query: 14 EEEFIADEEVGEEVVLDNVEPSENIGDDDDNDQEMGGLDGAETLEIDMSNNSSGFFDKHT 73
+E +IA+ EV EEV+ DN + + +D+ +QE D + +DMS GFF+ H
Sbjct: 8 QELYIAENEV-EEVIKDNDKLMDQGVTEDEAEQEQN--DTMNNMVMDMS--VQGFFE-HK 61
Query: 74 DSIFCIAHHPTLP-LVMTGGADNVANLW--TSHSKPPKFAGSLEHTESVISGGFTPDGKF 130
DS+F ++ +P L +GG D++ +W T+ + + G H +S+++ ++ DG +
Sbjct: 62 DSVFSVSINPVHSNLCASGGGDDLGYIWDITTGEQICQLTG---HKDSIVAIDWSFDGTY 118
Query: 131 LITADMNGKVFIHKSVKGGAQWKRCSXXXXXXXXXWLKVHPTVSGVFAFGGV-DGSVWCY 189
+ T M+ +V + KS G ++ + WL HP G+F G DGS+W +
Sbjct: 119 IATGGMDSQVRLWKSSTG---FEFITAFETVDEIVWLSWHP--KGLFLAAGCNDGSIWMW 173
Query: 190 QLNNVDGSLSQIMSGFSHQQDCTMGEFINVEEGENNLTLVTCSLDSSIVAWNCYMGQPLF 249
L + G + Q+M G H G+FI G+ L T +++ WN G P
Sbjct: 174 SLPS--GKVVQVMYG--HTAPVNAGKFIPPGVGKR---LATVDDSGTLIVWNPATGAPEC 226
Query: 250 KITQADIK---GLEAPWVSLSAAPASLTNNTAVIAAGSNNGLLAIINCSNGSVLHLTTVI 306
+++ D + G E ++ + N V+ G ++G + ++N ++ H+ +
Sbjct: 227 RMSSDDHRFDPGNEETAAGWTSFDCNAEGN--VLFLGGSSGKVKVVNINSS---HILASL 281
Query: 307 ELKPEQDELDASIESITWSSKLPLMAIGLVCGDALLYDTKTWRVRHKFQLEDSATKLQFD 366
E + E S+E+I + LP+ A V G LYD+ + + R E + +F
Sbjct: 282 EAQTE------SVEAIALCTALPICACASVDGTVALYDSASLKFRKSLPHEQAVIDCKF- 334
Query: 367 TINGHNLIASCINGKVYIFDARTGQEVHVCVGHNMGVLDFVVIENGSKLITAGDEGVSLI 426
N L+ +C + + +D R+GQ + GH +L + +G +++T D+ L+
Sbjct: 335 LPNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQEPILCMAITPDGKRVVTGSDDTELLV 394
Query: 427 FD 428
FD
Sbjct: 395 FD 396
>Hs4557229 [S] KOG0296 Angio-associated migratory cell protein (contains WD40
repeats)
Length = 452
Score = 108 bits (271), Expect = 1e-23
Identities = 114/448 (25%), Positives = 196/448 (43%), Gaps = 60/448 (13%)
Query: 9 ADNVPEE--EFIADEEVGEEVVLDNVEPSENIGDDDDNDQEMGGLDGAETLE-------- 58
AD P E F DEE+ E V LD P D DD QEM +D E E
Sbjct: 29 ADTPPLETLSFHGDEEIIEVVELDPGPP-----DPDDLAQEMEDVDFEEEEEEEGNEEGW 83
Query: 59 -----------IDMSNNSSGFFDKHTDSIFCIAHHP-TLPLVMTGGADNVANLWTSHSKP 106
++ ++S F H+ S+FC++ P T L +TGG D+ A +W
Sbjct: 84 VLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGE 143
Query: 107 PKFAGSLEHTESVISGGFTPDGKFLITADMNGKVFIHKSVKGGAQWKRCSXXXXXXXXXW 166
F + H +SV GF+ D + T DM+G + + + W W
Sbjct: 144 LLFECA-GHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWS-----FEAGDLEW 197
Query: 167 LKVHPTVSGVFAFGGVDGSVWCYQLNNVDGSLSQIMSGFSHQQDCTMGEFINVEEGENNL 226
++ HP + A G DG+ W +++ N D Q T G + +
Sbjct: 198 MEWHPRAPVLLA-GTADGNTWMWKVPNGDCKTFQ-----GPNCPATCGRVL-----PDGK 246
Query: 227 TLVTCSLDSSIVAWNCYMGQPLFKITQADIKGLEAPWVSLSAAPASLTNNTAVIAAGSNN 286
V D +I W+ G P+ + KG E L+ A+ + ++I GS +
Sbjct: 247 RAVVGYEDGTIRIWDLKQGSPIHVL-----KGTEGHQGPLTCVAAN--QDGSLILTGSVD 299
Query: 287 GLLAIINCSNGSVLHL--TTVIELKP---EQDELDA-SIESITWSSKLPLMAIGLVCGDA 340
+++ + G V+ + + +P E +E ++ S+ES+ + S +PL A+G + G
Sbjct: 300 CQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTL 359
Query: 341 LLYDTKTWRVRHKFQLEDSATKLQFDTINGHNLIASC-INGKVYIFDARTGQEVHVCVGH 399
+YD T +RH+ Q + +L ++ G ++ +C ++G V ++DARTG+ + GH
Sbjct: 360 AIYDLATQTLRHQCQHQSGIVQLLWEA--GTAVVYTCSLDGIVRLWDARTGRLLTDYRGH 417
Query: 400 NMGVLDFVVIENGSKLITAGDEGVSLIF 427
+LDF + ++ S ++T + + +F
Sbjct: 418 TAEILDFALSKDASLVVTTSGDHKAKVF 445
>At1g71840 [S] KOG0296 Angio-associated migratory cell protein (contains WD40
repeats)
Length = 390
Score = 93.6 bits (231), Expect = 5e-19
Identities = 105/430 (24%), Positives = 181/430 (41%), Gaps = 51/430 (11%)
Query: 1 MDNTELNTADNVPEEEFIADEEVGEEVVLDNVEPSENIGDDDDNDQEMGGLDGAETLEID 60
M+N + D E F+ + +V E+ +D + E DD D+D E + D
Sbjct: 1 MNNLAMEEEDE--GEIFLGESDVLREIDVDEEDLPEADDDDMDDDGE----------QFD 48
Query: 61 MSNNSSGFFDKHTDSIFCIAHHPT-LPLVMTGGADNVANLWTSHSKPPKFAGSLE-HTES 118
+++S F H ++ +A PT LV TGG D+ A LW + +A L H +S
Sbjct: 49 ENDDSVHTFTGHKGELYALACSPTDATLVATGGGDDKAFLWKIGNGD--WAAELPGHKDS 106
Query: 119 VISGGFTPDGKFLITADMNGKVFIHKSVKGGAQWKRCSXXXXXXXXXWLKVHPTVSGVFA 178
V F+ DG+ L + ++G V I + G +C W++ HP V A
Sbjct: 107 VSCLAFSYDGQLLASGGLDGVVQIFDASSGTL---KCVLDGPGAGIEWVRWHPRGHIVLA 163
Query: 179 FGGVDGSVWCYQLNNVDGSLSQIMSGFSHQQDCTMGEFINVEEGENNLTLVTCSLDSSIV 238
G D S+W + + + + SG H + T G+F + + T S D+S++
Sbjct: 164 -GSEDCSLWMWNADKE--AYLNMFSG--HNLNVTCGDFT-----PDGKLICTGSDDASLI 213
Query: 239 AWNCYMGQPLFKITQADIKGLEAPWVSLSAAPASLTNNTAVIAAGSNNGLLAIINCSNGS 298
WN P +GL + +N+++ +GS +G + I+N G
Sbjct: 214 VWNPKTCHPYHT------EGLTC---------LDINSNSSLAISGSKDGSVHIVNIVTGK 258
Query: 299 VLHLTTVIELKPEQDELDASIESITWSSKLPLMAIGLVCGDALLYDTKTWRVRHKFQLED 358
V V L D ++ ++ S+ +PL A G + +++D + R + E+
Sbjct: 259 V-----VSSLNSHTDSVEC-VKFSPSSATIPLAATGGMDKKLIIWDLQHSTPRFICEHEE 312
Query: 359 SATKLQFDTINGHNLIASCINGKVYIFDARTGQEVHVCVGHNMGVLDFVVIENGSKLITA 418
T L + + + L C NG V I+D+ G VH GH V V N +++
Sbjct: 313 GVTSLTWIGTSKY-LATGCANGTVSIWDSLLGNCVHTYHGHQDAVQAISVSTNTDFIVSV 371
Query: 419 GDEGVSLIFD 428
+ + +F+
Sbjct: 372 SVDNTARVFE 381
>7294340 [S] KOG0296 Angio-associated migratory cell protein (contains WD40
repeats)
Length = 425
Score = 83.6 bits (205), Expect = 5e-16
Identities = 96/435 (22%), Positives = 181/435 (41%), Gaps = 40/435 (9%)
Query: 5 ELNTADNVPEEEFIADEEVGEEVVLDNVEPSENI-GDDDDNDQEMGGLDGAETLEIDMSN 63
EL + E+ D++ EEV L+ +E + G DDD +++ L E + +++
Sbjct: 18 ELQEIIELEEQPLDEDDDDLEEVTLEQLEARLAMAGGDDDEEEDEEELRDRERIAA-ITD 76
Query: 64 NSSGFFDKHTDSIFCIAHHPTLPLVMTGGADNVANLWTSHSKPPKFAGSLEHTESVISGG 123
++ F KHT +F + HP +TG D+ A +W + + + + EH ++V
Sbjct: 77 EATVTFKKHTAPVFACSLHPNYNWAVTGSEDDRAFVWETSTGDVLYEIT-EHKDTVTETH 135
Query: 124 FTPDGKFLITADMNGKVFIHKSVKGGAQWKRCSXX--XXXXXXXWLKVHPTVSGVFAFGG 181
F+ DG +L T D+ G +F+ K + + + WL H + A G
Sbjct: 136 FSHDGVYLATGDLAGDLFVFKVSEKHDERPILTKIWEYSMSDMSWLFWHRAAHILLA-GS 194
Query: 182 VDGSVWCYQLNNVDGSLSQIMSGFSHQQDCTMGEFINVEEGENNLTLVTCSLDSSIVAWN 241
G V+ +++ + + +I+ G S + C GE + L T ++ S+ W+
Sbjct: 195 DSGEVFVFRIPSGE---CKILPGQSSR--CESGELSG-----DGKKLFTAYVNGSVKLWD 244
Query: 242 CYMGQPLFKITQADIKGLEAPWVSLSAAPASLTNNTAVIAAGSNNGLLAIINCSNGSVLH 301
Q L + ++ P T + A + ++G +L
Sbjct: 245 LKSCQVLIDVNESH--------------PMGFGEITHAVVACERESPFYVCAEASGKMLF 290
Query: 302 LTTVIELKPEQDELDASIESITW---SSKLPLMAIGLVCGDALLYDTKTWRVRHKFQL-- 356
T + Q E IE + + S+ L L A G + G ++D +R +
Sbjct: 291 CTNNGPVSTIQSE--HGIECLAFAPSSADLKLFACGSLDGRISIWDYAKSALRTICENPV 348
Query: 357 -EDSATKLQFDTINGHNLIASCINGKVYIFDARTGQEVHVCVGHNMGVLDFVVIENGSKL 415
D+ ++++ +N H ++A+ G + FDARTG GH + +FV + L
Sbjct: 349 PNDAVIRIKW--LNDHTILAATSQGNLNAFDARTGILKFTLTGHYYHIYEFVYKPQENLL 406
Query: 416 ITAGDEGVSLIFDLP 430
+T ++ + IF +P
Sbjct: 407 LTVSEDNTAKIFKVP 421
>CE26629 [S] KOG0296 Angio-associated migratory cell protein (contains WD40
repeats)
Length = 213
Score = 54.3 bits (129), Expect = 3e-07
Identities = 49/199 (24%), Positives = 84/199 (41%), Gaps = 17/199 (8%)
Query: 18 IADEEVGEEVVLDNVEPSENIGDDDDNDQEMGGLDGAETLEIDMSNNSSGFFDKHTDSIF 77
I + E+ E + +D+ + DD+D AE ++ + + H F
Sbjct: 8 IEESEIDEIIEIDDDAEMKYASDDEDQQSTSNADVPAEIIDDSLMS-----LQAHAQDCF 62
Query: 78 CIAHHPTLPLVMTGGADNVANLWTSHSKPPKFAGSLEHTESVISGGFTPDGKFLITADMN 137
+A L TGG D+VA L+ + + +EH +SV F L T D++
Sbjct: 63 TVALASNRWLA-TGGEDDVAFLFDQNQSESEPVLKVEHKDSVTQVMFNHSETLLATGDLS 121
Query: 138 GKVFIHK--SVKGGAQWKRCSXXXXXXXXXWLKVHPTVSGVFAFGGVDGSVWCYQLNNVD 195
GK+ I + + K A+ C+ W+ H T +FA G DG +W + + N
Sbjct: 122 GKIMISEMATKKVRAEIDECN------DLEWMCWHQTADILFA-GDKDGILWMWLIGNKG 174
Query: 196 GSLSQIMSGFSHQQDCTMG 214
+ S++ +G + CT G
Sbjct: 175 IAQSKVYAG--NGSSCTTG 191
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,737,669
Number of Sequences: 60738
Number of extensions: 1239631
Number of successful extensions: 5976
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 5935
Number of HSP's gapped (non-prelim): 8
length of query: 431
length of database: 30,389,216
effective HSP length: 109
effective length of query: 322
effective length of database: 23,768,774
effective search space: 7653545228
effective search space used: 7653545228
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)