ORF      STATUS       Function Best COG  Functional category                                          Pathways and functional systems
r_klactIV4219   suspect: Pn   T     KOG4225  Signal transduction mechanisms                                 Sorbin and SH3 domain-containing protein

BLASTP 2.2.3 [May-13-2002]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= r_klactIV4219 1431636 1430956 -227 
         (227 letters)

Database: KOG eukaryal database 04/03 
           60,738 sequences; 30,389,216 total letters

Searching..................................................done

Color Key for Alignment Scores:   


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Hs7661700 [T] KOG4225 Sorbin and SH3 domain-containing protein         50   2e-06
Hs5454056 [T] KOG4225 Sorbin and SH3 domain-containing protein         50   2e-06
Hs20533142 [O] KOG2177 Predicted E3 ubiquitin ligase                   48   1e-05

>Hs7661700 [T] KOG4225 Sorbin and SH3 domain-containing protein
          Length = 816

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 20/51 (39%), Positives = 33/51 (64%)

Query: 67  AMYAFVPENDNELELKEGDVVYISYKHGQGWLVAENHDRSKTGLVPEEYVQ 117
           A+Y+++P+ND+ELEL++GD+V +  K   GW V  +    + G  P  YV+
Sbjct: 762 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812


>Hs5454056 [T] KOG4225 Sorbin and SH3 domain-containing protein
          Length = 684

 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 20/51 (39%), Positives = 33/51 (64%)

Query: 67  AMYAFVPENDNELELKEGDVVYISYKHGQGWLVAENHDRSKTGLVPEEYVQ 117
           A+Y+++P+ND+ELEL++GD+V +  K   GW V  +    + G  P  YV+
Sbjct: 630 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680


>Hs20533142 [O] KOG2177 Predicted E3 ubiquitin ligase
          Length = 888

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 22/60 (36%), Positives = 35/60 (57%)

Query: 60  IVNKRAIAMYAFVPENDNELELKEGDVVYISYKHGQGWLVAENHDRSKTGLVPEEYVQLI 119
           +V +R   + ++ P+++ ELELKEGD+V++  K   GW         KTGL P  +V+ I
Sbjct: 829 VVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888


  Database: KOG eukaryal database 04/03
    Posted date:  Apr 14, 2003  1:07 PM
  Number of letters in database: 30,389,216
  Number of sequences in database:  60,738
  
Lambda     K      H
   0.309    0.132    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,464,661
Number of Sequences: 60738
Number of extensions: 640612
Number of successful extensions: 1622
Number of sequences better than 1.0e-05: 3
Number of HSP's better than  0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1613
Number of HSP's gapped (non-prelim): 9
length of query: 227
length of database: 30,389,216
effective HSP length: 103
effective length of query: 124
effective length of database: 24,133,202
effective search space: 2992517048
effective search space used: 2992517048
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)