ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV4361 good U KOG0929 Intracellular trafficking, secretion, and vesicular transport Guanine nucleotide exchange factor
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV4361 1483069 1477526 -1848
(1848 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR170c [U] KOG0929 Guanine nucleotide exchange factor 2148 0.0
SPAC30.01c [U] KOG0929 Guanine nucleotide exchange factor 994 0.0
SPAC4D7.01c [U] KOG0929 Guanine nucleotide exchange factor 966 0.0
Hs5453573 [U] KOG0929 Guanine nucleotide exchange factor 640 0.0
Hs5453571 [U] KOG0929 Guanine nucleotide exchange factor 637 0.0
7298092 [U] KOG0929 Guanine nucleotide exchange factor 634 0.0
At1g01960 [U] KOG0929 Guanine nucleotide exchange factor 589 e-167
At3g60860 [U] KOG0929 Guanine nucleotide exchange factor 585 e-166
At4g38200 [U] KOG0929 Guanine nucleotide exchange factor 538 e-152
At4g35380 [U] KOG0929 Guanine nucleotide exchange factor 500 e-141
CE24576 [U] KOG0929 Guanine nucleotide exchange factor 464 e-130
At3g43300 [U] KOG0929 Guanine nucleotide exchange factor 287 1e-76
At1g13980 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 185 5e-46
At5g19610 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 170 2e-41
At5g39500 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 165 6e-40
Hs8670544 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 165 7e-40
Hs4758964 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 165 7e-40
Hs8670546 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 163 3e-39
Hs4758966 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 163 3e-39
7302131 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin... 162 5e-39
Hs4758416 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 161 1e-38
Hs4758968 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 157 1e-37
Hs7019505 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 153 2e-36
SPBC211.03c [U] KOG0928 Pattern-formation protein/guanine nucleo... 145 6e-34
CE19701 [U] KOG0928 Pattern-formation protein/guanine nucleotide... 142 7e-33
YJR031c [U] KOG0928 Pattern-formation protein/guanine nucleotide... 140 2e-32
Hs7662290 [U] KOG0931 Predicted guanine nucleotide exchange fact... 140 2e-32
Hs14767357 [U] KOG0931 Predicted guanine nucleotide exchange fac... 135 5e-31
YEL022w [U] KOG0928 Pattern-formation protein/guanine nucleotide... 134 1e-30
Hs14764245 [U] KOG0931 Predicted guanine nucleotide exchange fac... 133 3e-30
7303476 [U] KOG0928 Pattern-formation protein/guanine nucleotide... 132 4e-30
7296387 [U] KOG0931 Predicted guanine nucleotide exchange factor... 129 6e-29
CE26942 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin... 113 3e-24
7300886 [U] KOG0932 Guanine nucleotide exchange factor EFA6 110 2e-23
Hs4506161 [U] KOG0932 Guanine nucleotide exchange factor EFA6 107 2e-22
Hs6912706 [U] KOG0932 Guanine nucleotide exchange factor EFA6 100 3e-20
Hs7662396 [U] KOG0932 Guanine nucleotide exchange factor EFA6 99 6e-20
CE12328 [U] KOG0931 Predicted guanine nucleotide exchange factor... 98 1e-19
Hs14150035 [U] KOG0932 Guanine nucleotide exchange factor EFA6 94 3e-18
Hs22064762 [U] KOG0930 Guanine nucleotide exchange factor Cytohe... 91 1e-17
CE29066 [U] KOG0932 Guanine nucleotide exchange factor EFA6 88 1e-16
CE19234 [U] KOG0932 Guanine nucleotide exchange factor EFA6 88 1e-16
Hs15812208 [U] KOG0929 Guanine nucleotide exchange factor 75 1e-12
SPAC26F1.01 [U] KOG0929 Guanine nucleotide exchange factor 69 7e-11
ECU10g1140 [U] KOG0928 Pattern-formation protein/guanine nucleot... 67 2e-10
YPR095c [U] KOG0929 Guanine nucleotide exchange factor 61 1e-08
SPAC11E3.11c [U] KOG0929 Guanine nucleotide exchange factor 61 1e-08
CE17656 [S] KOG1848 Uncharacterized conserved protein 55 1e-06
7290667 [U] KOG1846 Uncharacterized conserved protein contains S... 54 3e-06
>YDR170c [U] KOG0929 Guanine nucleotide exchange factor
Length = 2009
Score = 2148 bits (5565), Expect = 0.0
Identities = 1099/1836 (59%), Positives = 1400/1836 (75%), Gaps = 75/1836 (4%)
Query: 63 TVNSNTEGAAHARNASIVSMNNANIKSVVLFVKSTLESIMKSKELKKLTSCQKDIERTLK 122
T +S + H RN S+ S N +N S ++ VK+TLE+I+ K++KK ++ QK IERTL+
Sbjct: 197 TNDSTAPRSTHTRNISL-SSNGSNTNSTIILVKTTLETILNDKDIKKNSNAQKAIERTLQ 255
Query: 123 SLEQTSAAPTGTSVEIDSLLVFEALRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVN 182
++ T +DS+LVFEALR+ CR+K +Q ALDC +KLFSF++LDE+LLVN
Sbjct: 256 KFKEFDPQTTNNPHYVDSILVFEALRASCRTKSSKVQSLALDCLSKLFSFRSLDETLLVN 315
Query: 183 PPDSMASNDQNPENI-GITPPPKQKLIDAVIDTICDCFEGENTDSRVELQVVRGLASCIL 241
PPDS+ASNDQ + GITPPPKQK+IDA IDTI DCF+GE TD RVELQ+VR L+SCIL
Sbjct: 316 PPDSLASNDQRQDAADGITPPPKQKIIDAAIDTISDCFQGEGTDDRVELQIVRALSSCIL 375
Query: 242 IDEATSCVHGASLLKAIRQIYNIFIFSLHSSNQGIAQATLTQIVTTVFDRIDVK-SLNQQ 300
++++S HGASLLKAIR IYN+F+FSL+ SNQGIAQATLTQI+++V+D+ID+K S +
Sbjct: 376 EEDSSSLCHGASLLKAIRTIYNVFVFSLNPSNQGIAQATLTQIISSVYDKIDLKQSTSSA 435
Query: 301 RSLSTISLKNAASTNGGTSTPSSEHP--LTLQNLDTLNDETERLVDEEENFQKPDDSITD 358
SLST + + ++ ++ ++E P LTL+N+D LND+ ERL+D Q+PD
Sbjct: 436 VSLSTKNHQQQSAIELSEASENAETPAPLTLENMDKLNDDEERLMDA----QQPDSIAIT 491
Query: 359 EQALTIKDAFLLFRAMAKISAKPLEDSLDMRSHVVRSKLLSLHTLHSILKDHIDVFLSQN 418
Q L +KDAFL+FR MAKI AKPLE LDMRSH VRSKLLSLH ++SI+KDHIDVFLS N
Sbjct: 492 NQDLAVKDAFLVFRVMAKICAKPLETELDMRSHAVRSKLLSLHIIYSIIKDHIDVFLSHN 551
Query: 419 VRVPGKEQVSLVHAVNQYLCLSLARNAASPIAPVYEITLEIMWLIISNLRSEFKREIPVF 478
+ +PGKE+V + ++ QYL L L+RNAASP+APV+E+TLEIMWL+I+NLR++F +EIPVF
Sbjct: 552 IFLPGKERVCFIDSIRQYLRLVLSRNAASPLAPVFEVTLEIMWLLIANLRADFVKEIPVF 611
Query: 479 LTDIYFPIADLKSSTNHQKRYFLSIIQRVCNDPRTLIEFYLNYDCDSHMPNVVELIINYL 538
LT+IYFPI++L +ST+ QKRYFLS+IQR+CNDPRTL+EFYLNYDC+ MPNV+E+ ++YL
Sbjct: 612 LTEIYFPISELTTSTSQQKRYFLSVIQRICNDPRTLVEFYLNYDCNPGMPNVMEITVDYL 671
Query: 539 TKLALTRVDVTTSQRAYYNDSLSKPLATFSYTQVXXXXXXXXXXX--XXXXXXXFPVDYA 596
T+LALTRV++T +QR+YY++ +SK L+T++++Q+ FP+D+A
Sbjct: 672 TRLALTRVEITQTQRSYYDEQISKSLSTYNFSQLPLLTSSNLSSSPDVGQVNLLFPLDFA 731
Query: 597 LKQMALTCMVAFLTSLSSWAHKALNSSS-------INTVGSSQSKALSQRADS--STLLS 647
LK ++L C+V+ L SLSSWAHKALN ++ +NT S++ ++ S ++ S++++
Sbjct: 732 LKMVSLNCIVSVLRSLSSWAHKALNPNTHTANKVLLNTTSSARQESRSSLSNDVRSSIMT 791
Query: 648 SNRPRSTSALXXXXXXXXXXXXXXXXXXXXXDPLQFETAKLRKTELLNCVKLFNYKTKKG 707
SN + DP QFE KLRKT L C+ +FN K KK
Sbjct: 792 SNDDFKPT------YEDEESRSLSSQNIDADDPTQFENLKLRKTALSECIAIFNNKPKKA 845
Query: 708 IAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNL 767
I IKKGF++DDS ++IAKWLL T+GLD++AVG+YLGEG++KNI+IMHAFVD+F+FT +
Sbjct: 846 IPVLIKKGFLKDDSPISIAKWLLETEGLDMAAVGDYLGEGDDKNIAIMHAFVDEFDFTGM 905
Query: 768 SIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTD 827
SIV ALR FLQ FRLPGEGQKIDRFMLKFAERFVDQNP VFSKADTAYVL+YS+I+LNTD
Sbjct: 906 SIVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSKADTAYVLSYSLIMLNTD 965
Query: 828 LHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQHQAMISGDA 887
LHS+QIK KM+L+EF+ENN GIDNG+DLPR+++E +F EI+N+EIKL+SEQHQAM+SGD
Sbjct: 966 LHSSQIKNKMSLQEFLENNEGIDNGRDLPRDFLEGLFNEIANNEIKLISEQHQAMLSGDT 1025
Query: 888 TAALPQQSSFGFFNGKDYEREAYIQVSKQISSKTELVFKNLSKNKD--TVYYAASHVEHV 945
QQS+F FFN +D REAY QVSK+ISSKTELVFKNL+KNK VYYAASHVEHV
Sbjct: 1026 NLVQQQQSAFNFFNSRDLTREAYNQVSKEISSKTELVFKNLNKNKGGPDVYYAASHVEHV 1085
Query: 946 KSIFETLWMSFLAALTPPFKEYNDIETSDLCLKGIKTSIKIAATFGIDYARASFVGALIQ 1005
KSIFETLWMSFLAALTPPFK+Y+DI+T++ CL+G+K SIKIA+TF I+ AR SFVGAL+Q
Sbjct: 1086 KSIFETLWMSFLAALTPPFKDYDDIDTTNKCLEGLKISIKIASTFRINDARTSFVGALVQ 1145
Query: 1006 FANLQNLEEIKIKNVYAIITLLEIAVSEGNYMKDSWKDILVIVSQVERLQLISKGVDRET 1065
F NLQNLEEIK+KNV A++ LLE+A+SEGNY++ SWKDIL++VSQ+ERLQLISKG+DR+T
Sbjct: 1146 FCNLQNLEEIKVKNVNAMVILLEVALSEGNYLEGSWKDILLVVSQMERLQLISKGIDRDT 1205
Query: 1066 VPDVTQARLANHXXXXXXXXXXXXQNFFDRWTRKATPGEIAQEKHYNQTLSPNISKFITS 1125
VPDV QAR+AN +FFD W +KATP E+AQEKH+NQTLSP ISKFI+S
Sbjct: 1206 VPDVAQARVANPRVSYESSRSNNT-SFFDVWGKKATPTELAQEKHHNQTLSPEISKFISS 1264
Query: 1126 SELVVLIDKIFTNSSALSGSAIVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYY 1185
SELVVL+D IFT SS LSG+AIVDFIKALT VS EEIESS+NA+TPRMFSLQKMVDVCYY
Sbjct: 1265 SELVVLMDNIFTKSSELSGNAIVDFIKALTAVSLEEIESSENASTPRMFSLQKMVDVCYY 1324
Query: 1186 NMDRIRLEWTPIWNVMGEAFNRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLD 1245
NMDRI+LEWTP+W VMG+AFN+IAT SNLAVVFFAIDSLRQLSMRFLDIEEL+GFEFQ D
Sbjct: 1325 NMDRIKLEWTPLWAVMGKAFNKIATNSNLAVVFFAIDSLRQLSMRFLDIEELSGFEFQHD 1384
Query: 1246 FLKPFEHTVENTRDIDVQEMCIECFHNFILTKSGKIKSGWKPILKSLQYTAQSPNERIVT 1305
FLKPFE+TV+N+ + +VQEM IECF NFILTKS IKSGWKPIL+SLQYTA+S E IV
Sbjct: 1385 FLKPFEYTVQNSGNTEVQEMIIECFRNFILTKSESIKSGWKPILESLQYTARSSTESIVL 1444
Query: 1306 RTYELVSYDIVKDHFYXXXXXXXXXXXXXXXXKEITKNQKHQKLALHSLETLKRITNQVA 1365
+T LVS DIV +HF +EITKN++ QKL+LH+LE+L+++T VA
Sbjct: 1445 KTQLLVSNDIVTNHFENVFSQEDAFSELVGVFREITKNKRFQKLSLHALESLRKMTQNVA 1504
Query: 1366 DLCFKN---------HDHQLLQGKDEFEDVWLPLLFCFNDTIMTAVDLEVRSRALNYMFD 1416
D+CF N H+ LL+GKD F+DVW P+LFCFNDTIMTA DLEVRSRALNYMFD
Sbjct: 1505 DICFYNENKTEEERKHNDALLRGKDIFQDVWFPMLFCFNDTIMTAEDLEVRSRALNYMFD 1564
Query: 1417 ALVANGAEFDEEFWNKICTQLLFPIFGILSKHWEVNQFNSHDDMSVWLSTTLIQALRNMV 1476
ALVA G +F+++FW KIC +LLFPIFG+LSKHWEVNQFNSHDD+SVWLSTTLIQALRN++
Sbjct: 1565 ALVAYGGKFNDDFWEKICKKLLFPIFGVLSKHWEVNQFNSHDDLSVWLSTTLIQALRNLI 1624
Query: 1477 ALFTHYFESLNGLLDGVLGLMVSCICQENDTIARIGRSCLQQLILQNMSEFNDTHWHQVT 1536
ALFTHYFESLN +LDG LGL+VSCICQENDTIARIGRSCLQQLILQN+S+FN+ HW+Q+
Sbjct: 1625 ALFTHYFESLNRMLDGFLGLLVSCICQENDTIARIGRSCLQQLILQNVSKFNEYHWNQIG 1684
Query: 1537 EAFSTLFQLTTANELFESDPLKQGRRKSVPN---TAGTDXXXXXXXXXXXXXXXXXXXXX 1593
+ F LF LTTANELF+ DPL+QGR+ SV + T T
Sbjct: 1685 DVFDKLFDLTTANELFDYDPLQQGRKSSVSHHQTTNDTSQHSDDDSNDRRENDSNISETV 1744
Query: 1594 XXXXXXXNGQDVG-------NEQGTISNGDI-----DALPP-----------RRLVETKS 1630
+ +DVG N Q ++NG+ D L P + + +S
Sbjct: 1745 ERAHQEESSEDVGGDMVETLNGQTKLNNGNSVPTVKDELNPKPASLSIPKKTKHMKRNES 1804
Query: 1631 TEELKQKVSVKNTIVVKCILQLLMIESLSELFEVEQFINSIPFDEAIKLTTLLERSYEFA 1690
E++++++++KN+IVVKC+LQLLMIE L+ELFE E F + IP+ EAI++T LLE+SYEF+
Sbjct: 1805 NEDIRRRINIKNSIVVKCVLQLLMIELLNELFENEDFAHCIPYKEAIRITRLLEKSYEFS 1864
Query: 1691 RDFNDDYELRTRLVEARVSNKIPNLAKQETSSSAVLINILFKLYLNRESSENGSTKEIKK 1750
RDFN+DY LRTRLVEARV +KIPNL KQETS++AVL++I+F+LYLN + +
Sbjct: 1865 RDFNEDYGLRTRLVEARVVDKIPNLLKQETSAAAVLLDIMFQLYLNDD-----------E 1913
Query: 1751 NQKNLLQRLVGICVSIVQRYVAMNDGVSERAANNWRPVIVEIIQGYSEFDDNDYKQQCKT 1810
+ +L+ RL+ IC+ +V+ YV+++D ER+ N WR VIVEI+QGY EFDD D++ C
Sbjct: 1914 KKADLITRLITICIQVVEGYVSLDDRTMERSINAWRSVIVEILQGYYEFDDEDFRLYCPA 1973
Query: 1811 MYDLILQILDKPCPDDLRHVIRLFLTRTRDIFLDSE 1846
MY L++QILDK P +LRH I+ FL+R +++L ++
Sbjct: 1974 MYALVIQILDKSVPTELRHAIKQFLSRVGELYLSTD 2009
>SPAC30.01c [U] KOG0929 Guanine nucleotide exchange factor
Length = 1822
Score = 994 bits (2571), Expect = 0.0
Identities = 617/1841 (33%), Positives = 969/1841 (52%), Gaps = 109/1841 (5%)
Query: 23 DSTTTVDINVNSVTDADANVENNXXXXXXXXXXXXXXANKTVNSNTEGAAHARNASIVSM 82
D+ ++DIN + + A EN SN A +A+ +
Sbjct: 66 DAVVSIDINTEDSSLSPAKQENEKSPEGIEQKYQEEDLKDDKKSNETIATPVPDAASRAS 125
Query: 83 NNANIKSVVLFVKSTLESIMKS-KELKKLTSCQKDIERTLKSLEQTSAAPTGTSVEIDSL 141
+ KST ++K ++L ++ C K+ +K+L + T + D
Sbjct: 126 LEKQKSGLTNLEKSTHVVLIKCIEQLIQIKVCMKN--EKMKNLMEQLKPLLQTECQFDKF 183
Query: 142 LVFEALRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVNPPDSMASNDQNPENIGITP 201
L+ E + C S ++ +LD +KL SF +S D+ P + G
Sbjct: 184 LIVELFQYCFESSQDEVMNISLDTISKLASFAYF------------SSKDKTPASFG--- 228
Query: 202 PPKQKLIDAVIDTICDCFEGENTDSRVELQVVRGLASCILIDEATSCVHGASLLKAIRQI 261
PPK L+ ++D +CD E D ++L VV+ L++ IL E S +HGA LL ++R++
Sbjct: 229 PPKS-LLQCMVDMVCDSINDEVVDGNLQLNVVKALSAFILCSEQDSMLHGAILLNSVRKL 287
Query: 262 YNIFIFSLHSSNQGIAQATLTQIVTTVFDRIDVKSLNQQRSLSTISLKNAAST-NGGTST 320
+N+F+ + Q +AQA+LTQ VT V++R+ S Q S S + ++A+ T N
Sbjct: 288 FNVFLLGDSDTIQSVAQASLTQAVTVVYERLRA-SHTQSNSTSALPEEDASVTENWVHDE 346
Query: 321 PSSEHPLTLQNLDTLNDETERLVDEEENFQKPDDSITDEQALTIKDAFLLFRAMAKISAK 380
+ +TL ++ + + V + + D ++T + +I+DAFL+FR+M +++ +
Sbjct: 347 DEPDKKITLHSMASAGTSSLDHVKVDAD----DPAVTSVENSSIQDAFLVFRSMCRLAVR 402
Query: 381 PLEDSL--DMRSHVVRSKLLSLHTLHSILKDHIDVFLSQNVR---VPGKEQVSLVHAVNQ 435
++RS +R+KL+SLH ++ IL+ + D+F+ ++ +P + ++LVHA Q
Sbjct: 403 QTSPDKVSNIRSQAMRAKLISLHLIYRILEKNSDLFMDPTLQFRGIPALKGMTLVHASRQ 462
Query: 436 YLCLSLARNAASPIAPVYEITLEIMWLIISNLRSEFKREIPVFLTDIYFPIADLKSSTNH 495
Y+CL L+RNA SP+ V+E+ +I +L++ +LR+ FK+EI VF ++YFP+ DLK+++ +
Sbjct: 463 YICLVLSRNAVSPVPQVFEVCCDIFYLMVFSLRAHFKQEIEVFFREVYFPMLDLKNTSYN 522
Query: 496 QKRYFLSIIQRVCNDPRTLIEFYLNYDCD-SHMPNVVELIINYLTKLALTRVDVTTSQRA 554
QK + L IIQR+C +PR L+E Y+NYDCD S NV E ++ ++K+ T S+
Sbjct: 523 QKLHTLLIIQRICLNPRALVELYINYDCDRSSTTNVFEQLLFSISKVTTNGPSETISEDI 582
Query: 555 YYNDSLSKPLATFSYTQVXXXXXXXXXXXXXXXXXXFPVDYALKQMALTCMVAFLTSLSS 614
+ + L + + D+ LK L C++ L SLS+
Sbjct: 583 ---EEILPSLESSERSSTPFLNTNSASLKSEVVQLTTFSDFQLKLKTLQCVLDILQSLSN 639
Query: 615 WAHKALNSSSINTVGSSQSKALSQRADSSTLLSSNRPRSTSALXXXXXXXXXXXXXXXXX 674
WA L S Q D L S+ P +
Sbjct: 640 WAESGLYLSRRGVSTDEQGFV----GDYDALSRSDTPVTNP--YYNGKQSFEANSHSSSS 693
Query: 675 XXXXDPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDG 734
DP QFE+ K RK L C+ FNYK +G+ + +++ + AIA++L DG
Sbjct: 694 IALADPSQFESNKQRKKLLRTCINKFNYKPTRGLKMLSENEYVDINDPKAIAEFLFRADG 753
Query: 735 LDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFML 794
+D + +G+YLGEG+EK+IS+MH F+D F NL V ALR LQ FRLPGE QKIDR ML
Sbjct: 754 IDKTTLGDYLGEGDEKSISVMHEFIDCLSFINLKFVDALRRLLQCFRLPGEAQKIDRIML 813
Query: 795 KFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKD 854
KF+ER++ +NP+ F+ ADTAY+LAYSIILLNTDLHS +IK KMT E+FI+NN GI++G D
Sbjct: 814 KFSERYMKENPSAFANADTAYILAYSIILLNTDLHSPRIKNKMTKEDFIKNNRGINDGAD 873
Query: 855 LPREYMEQIFEEISNHEIKLLSEQHQAMISGDATAALPQQSSFGFF--NGKDYEREAYIQ 912
L +Y+ ++++I +EI + +Q A I+ S F F NG+D +R A IQ
Sbjct: 874 LDEDYLGFVYDDILKNEIAMKDDQELAAIA-PLMNNFSTSSGFTTFTSNGRDLQRVACIQ 932
Query: 913 VSKQISSKTELVFKNL------SKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPPFKE 966
S+++++K V K L K VYY A+H EH+ + E WM LAAL+ P +
Sbjct: 933 ASEEMANKATSVLKKLLYQQKHGSQKTNVYYNATHFEHIGPMLEATWMPILAALSNPLQN 992
Query: 967 YNDIETSDLCLKGIKTSIKIAATFGIDYARASFVGALIQFANLQNLEEIKIKNVYAIITL 1026
+ + ++CL G + ++IA F +D R +F+ L F NL + EIK++N I TL
Sbjct: 993 SDYVNELNMCLDGFQLVVRIACLFDLDLIRDAFIKTLTNFTNLHSTSEIKLRNTMVIKTL 1052
Query: 1027 LEIAVSEGNYMKDSWKDILVIVSQVERLQLISKGVDRETVPDVTQARLANHXXXXXXXXX 1086
L IA +EGN +KDSWKDIL I+SQ+ER+QLI GVD VPDV AR+
Sbjct: 1053 LRIASTEGNNLKDSWKDILTIISQLERVQLIGVGVDETEVPDVINARVRRKNVNIGSSNS 1112
Query: 1087 XXXQNFFDRWTRKATPGEIAQEKHYNQTLSPNISKFITSSELVVLIDKIFTNSSALSGSA 1146
+ + + + ++ LSP + S+E+V+ ID+IFT +S+LSGSA
Sbjct: 1113 IRHVS--------GSTSRSTRTRSLSKPLSPEAVSELMSTEVVLSIDRIFTQTSSLSGSA 1164
Query: 1147 IVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNMDRIRLEWTPIWNVMGEAFN 1206
IV F KAL EVS++EI SS + PR++SLQK+V++ YYNM RIR+EW+ IWNV+G FN
Sbjct: 1165 IVSFFKALCEVSWDEITSSSDLEQPRLYSLQKLVEISYYNMQRIRVEWSSIWNVLGRFFN 1224
Query: 1207 RIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPFEHTVENTRDIDVQEMC 1266
+ ++ N V FA+DSLRQLSM FL+IEEL+ F FQ +FLKPFE+ + + ++V+E+
Sbjct: 1225 MVGSDENRHVAVFALDSLRQLSMHFLEIEELSLFSFQKEFLKPFEYVMASDTVVEVKELV 1284
Query: 1267 IECFHNFILTKSGKIKSGWKPILKSLQYTAQSPNERIVTRTYELVSYDIVKDHFYXXXXX 1326
++C I K KIKSGWK + + A++ +E +++ T++ + ++ +H Y
Sbjct: 1285 LQCVKQMIQAKISKIKSGWKTLFGVFTFAAKARSEILISMTFDTL-VNLFSEH-YDTLMQ 1342
Query: 1327 XXXXXXXXXXXKEITKNQKHQKLALHSLETLKRITNQVADLCFKNHDHQLLQGKDEFEDV 1386
E+ KN +QK++L SLE ++ + + ++ + K + F
Sbjct: 1343 QNCLIDMLISFTELCKNGTNQKISLQSLEIIREVYSSLSTM-IKEGLSSKPSVNETFSKY 1401
Query: 1387 WLPLLFCFNDTIMTAVDLEVRSRALNYMFDALVANGAEFDEEFWNKICTQLLFPIFGILS 1446
P+LF + D IM+A DLEVRSRAL +F + +F EE W + + +FPIF I
Sbjct: 1402 VFPVLFAYYDIIMSAEDLEVRSRALQNLFYIFLEESDDFTEETWEVVSRKFIFPIFSIFG 1461
Query: 1447 KHW-EVNQFNSHDDMSVWLSTTLIQALRNMVALFTHYFESLNGLLDGVLGLMVSCICQEN 1505
E +++ W STTL++ALR++V L T F+ L+ LL G L L +CIC++N
Sbjct: 1462 PEADEATVMLRDEEIRTWQSTTLVEALRSLVTLLTRRFDKLHNLLKGYLWLFSNCICRDN 1521
Query: 1506 DTIARIGRSCLQQLILQNMSEFNDTHWHQVTEAFSTLFQLTTANELFESDPLKQGRRKSV 1565
T++RIG +C+QQL+ N F W+ V + F LF+ TT ++L + G+ V
Sbjct: 1522 ITLSRIGTNCMQQLLSGNAYRFEVKDWNLVADMFIELFKETTPHQLLLLETFSNGQGAPV 1581
Query: 1566 PNTAGTDXXXXXXXXXXXXXXXXXXXXXXXXXXXXNGQDVGNEQGTISNGDIDALP-PRR 1624
+ NE +S+ +LP R
Sbjct: 1582 YSE--------------------------------------NENTQLSHKRGGSLPETSR 1603
Query: 1625 LVETKSTEELKQKVSVKNTIVVKCILQLLMIESLSELFEVEQFINSIPFDEAIKLTTLLE 1684
+ T S KQ +++ KCILQLL+I ++EL + E+ N IP + +K+T +
Sbjct: 1604 SISTSSISPEKQMEF--RSMIRKCILQLLLISIVAELLDNEEVFNHIPHEHVLKITVAIY 1661
Query: 1685 RSYEFARDFNDDYELRTRLVEARVSNKIPNLAKQETSSSAVLINILFKLYLNRESSENGS 1744
S++FAR FN+D LR L+ ++PNL +QET+S+ + I +LF+L R+ G
Sbjct: 1662 DSWQFARKFNEDKSLRITLLNVGFMKQLPNLLRQETASALLYITLLFRLLKTRDPL--GK 1719
Query: 1745 TKEIKKNQKNLLQRLVGICVSIVQRYVAMNDGVSERAANNWRPVIVEIIQGYSEFDDNDY 1804
T+ +K K L +C ++ Y ++ R W+PVI I+ +
Sbjct: 1720 TETDQKIHKLLFP----VCAEMLDMYASLVVEKHTRNHAAWQPVIATILDSILNLPLELF 1775
Query: 1805 KQQCKTMYDLILQILDKPCPDD-LRHVIRLFLTRTRDIFLD 1844
+ T+Y ++ K DD LR +++ + R I L+
Sbjct: 1776 SENIHTLYFSCCSMIAKENLDDQLRELLKNYFNRVGHILLN 1816
>SPAC4D7.01c [U] KOG0929 Guanine nucleotide exchange factor
Length = 1811
Score = 966 bits (2498), Expect = 0.0
Identities = 598/1835 (32%), Positives = 956/1835 (51%), Gaps = 152/1835 (8%)
Query: 29 DINVNSVTDADANVENNXXXXXXXXXXXXXXANKTVNSNTEGAAHA-------RNASIVS 81
D N+ + D ++N+ T++ T + A +N S S
Sbjct: 63 DKNLEAEKDIESNLSLRPPEDDLDSRSIESEQTGTLSKQTTSTSEAPQDLKIWKNISNAS 122
Query: 82 MNNANIKSVVLFVKSTLESIMKSKELKKLTSCQKDIERTLKSLE-QTSAAPTGTSVEIDS 140
N+ + LFV + + K+K K+ ++ I L+ Q P
Sbjct: 123 NQNSGKLNPQLFVIEAFKHMSKAKATKRHKKLREAINNVQIELQKQPFLLPE-------- 174
Query: 141 LLVFEALRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVNPPDSMASNDQNPENIGIT 200
++ E L C++ + LDCFAKL + D L NP +I
Sbjct: 175 -VILEPLVMACQTNSTTLLTITLDCFAKLIDYNYFDSPTL------------NPSDI--- 218
Query: 201 PPPKQKLIDAVIDTICDCFEGENTDSRVELQVVRGLASCILIDEATSCVHGASLLKAIRQ 260
L++ V++TI CF GE+T RV+LQ+V+ L + I + + + + LL A+RQ
Sbjct: 219 -----TLMERVVNTIASCFCGESTPERVQLQIVKALLAAITSER--TIIRHSFLLTAVRQ 271
Query: 261 IYNIFIFSLHSSNQGIAQATLTQIVTTVFDRIDVKSLNQQRSLSTISLKNAASTNGGTST 320
YNIF+ S+ Q IAQ L Q+V +VF R+ LN +R STI++ N +S+NG
Sbjct: 272 TYNIFLLCKDSTTQAIAQVALLQMVDSVFQRLSTV-LNHEREFSTINM-NKSSSNGTPDR 329
Query: 321 PSSEHPLTL-QNLDTLNDETERLVDEEENFQKPDDSITDEQALTIKDAFLLFRAMAKISA 379
+S P L +N TL R ++ + P + + EQ L ++DAFLL RA+ K+S
Sbjct: 330 ANSPIPSQLSENKLTLESFEHRKSFDQVREEAPLEEDSLEQQL-LRDAFLLIRALCKLSI 388
Query: 380 K--PLEDSLDMRSHVVRSKLLSLHTLHSILKDHIDVFLSQNVRV--PGKEQVSLVHAVNQ 435
K P E D++S +RSKL+SLH ++ IL+ ++++ NV++ P L+ AV Q
Sbjct: 389 KNIPYEHEYDLKSQSMRSKLMSLHLIYHILRTYMNILSDINVKIRSPTSTPTPLIDAVKQ 448
Query: 436 YLCLSLARNAASPIAPVYEITLEIMWLIISNLRSEFKREIPVFLTDIYFPIADLKSSTNH 495
Y+CL+LA+N S + PV+EI+ EI WLI+S L++ FK E+ VF T+I+FPI ++++S+N
Sbjct: 449 YICLALAKNVVSHVLPVFEISCEIFWLILSELKNFFKSELEVFFTEIFFPILEMRTSSNQ 508
Query: 496 QKRYFLSIIQRVCNDPRTLIEFYLNYDCDS-HMPNVVELIINYLTKLALTRVDVTTSQRA 554
QK L+I R+C +P+TLIE YLNYDC S + N+ E I L+++A
Sbjct: 509 QKIVLLNIFHRMCEEPQTLIELYLNYDCISGNTENIYERAIVTLSRIASQSTSDPPPSFV 568
Query: 555 YYNDSLSKPLATFSYTQVXXXXXXXXXXXXXXXXXXFP--VDYALKQMALTCMVAFLTSL 612
+ +D L F Y + P DY ++ + C+++ L+SL
Sbjct: 569 FRDDQLVIDKPGFVYHTLNDIPQLNSSTIGSYVHSHNPPYFDYQIRLKSYRCLISTLSSL 628
Query: 613 SSWAHKALNSSSINTVGSSQSKALSQRADSSTLLSSNRPRSTSALXXXXXXXXXXXXXXX 672
+W ++ + T ++++ S+ + S + P S
Sbjct: 629 FTWCNQTFAPTVEITAKDDETESTSKGEEPQK--SKSEPPSAGI----NSTSMDNLESSG 682
Query: 673 XXXXXXDPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNT 732
DP QFE K RK +L ++ FNYK K+GI + FI + IAK+L++T
Sbjct: 683 QALATDDPSQFENLKHRKKQLQEAIQKFNYKPKEGIKILLSSHFIASKTPTDIAKFLIST 742
Query: 733 DGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRF 792
+GLD + +GEYLGEGN++NI+IMH+FVD F ++ V+ALR FLQKFRLPGE QKIDRF
Sbjct: 743 EGLDKAVLGEYLGEGNDENIAIMHSFVDHMSFNDIPFVNALRSFLQKFRLPGEAQKIDRF 802
Query: 793 MLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNG 852
MLKFAE+++D N VF ADTAY+LAYSII+LNTDLHS Q+K +MT ++FI+NN G+D+G
Sbjct: 803 MLKFAEKYIDDNLGVFKNADTAYILAYSIIMLNTDLHSPQVKNRMTCQDFIKNNRGVDDG 862
Query: 853 KDLPREYMEQIFEEISNHEIKLLSEQHQAM----ISGDATAALPQQSSFGFFN-GKDYER 907
+L ++ +++EEI +EI L EQ I G + + S G+D +R
Sbjct: 863 ANLSDSFLTEVYEEIQKNEIVLKDEQDPTSNFPEIPGTSNLSFAANISNALATVGRDLQR 922
Query: 908 EAYIQVSKQISSKTELVFKNLSKNK--------DTVYYAASHVEHVKSIFETLWMSFLAA 959
EAY S ++++KTE +FK+L + + + +YY A H EHV +FE +WM LAA
Sbjct: 923 EAYYMASNKMANKTEALFKDLIREQRERGKLSGNDIYYTARHFEHVCPMFEAVWMPILAA 982
Query: 960 LTPPFKEYNDIETSDLCLKGIKTSIKIAATFGIDYARASFVGALIQFANLQNLEEIKIKN 1019
+ P + +D L L G + ++ + F +D R +F+ L +F +L N E+K N
Sbjct: 983 FSEPLQLSSDPALIQLSLDGFRLAMNVIFFFSMDLPRNAFMQTLTKFTHLNNTSELKWTN 1042
Query: 1020 VYAIITLLEIAVSEGNYMKDSWKDILVIVSQVERLQLISKGVDRETVPDVTQARLANHXX 1079
++A+ TLLEI+++ G+ ++DSWKD+L+ +SQ+ER+QLIS GVD ++PDV+ +
Sbjct: 1043 MHALKTLLEISLAHGDKLRDSWKDVLLCISQLERVQLISAGVDINSLPDVSTTK------ 1096
Query: 1080 XXXXXXXXXXQNFFDRWTRKATPGEI---------AQEKHYNQTLSPNISKFITSSELVV 1130
+ D+ R++ G I + H ++ S I + +S E+V+
Sbjct: 1097 --------PLRKSLDKNIRQSRSGSISLKHSKSFQSASTHSTKSSSVEIVREYSSREVVM 1148
Query: 1131 LIDKIFTNSSALSGSAIVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNMDRI 1190
+D +F+N+ L I DF+KAL EVS+EEIE S + PR+FSLQK+V++ YYNM RI
Sbjct: 1149 AVDMLFSNTRNLGSEGIYDFVKALIEVSWEEIECSLELSNPRLFSLQKLVEISYYNMRRI 1208
Query: 1191 RLEWTPIWNVMGEAFNRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPF 1250
R+EW+ IW+++G F +++ N + FA+DSLRQ SM+FL+IEEL+ F+FQ DFL+PF
Sbjct: 1209 RMEWSSIWSLLGTYFTQVSCHENSIIASFALDSLRQFSMQFLEIEELSHFKFQKDFLQPF 1268
Query: 1251 EHTVENTRDIDVQEMCIECFHNFILTKSGKIKSGWKPILKSLQYTAQSPNERIVTRTYEL 1310
H +EN++D+ ++++ + C I + I+SGW+ I L Y ++ N ++ +
Sbjct: 1269 SHAMENSQDLKIKDLVLRCIDQMIKARYQNIRSGWRTIFHILAYASKIENLLVLQCAISV 1328
Query: 1311 VSYDIVKDHFYXXXXXXXXXXXXXXXXKEITKNQKHQKLALHSLETLKRITNQVADLCFK 1370
VS + +H K K +QK L ++ LK + +++ K
Sbjct: 1329 VS-SLGHEHISCVLTQGAYIDLISCITK-FAKLNGNQKFCLSCVDMLKNLEHELIK-HLK 1385
Query: 1371 NHDHQLLQGKDEFEDVWLPLLFCFNDTIMTAVDLEVRSRALNYMFDALVANGAEFDEEFW 1430
+ + + K E+ WLP L FN+ I A DLEVRS+AL +FD L + +FDEEFW
Sbjct: 1386 HMKKESVYSKKLEEEYWLPFLLSFNEIICEASDLEVRSKALKVLFDCLYRHADDFDEEFW 1445
Query: 1431 NKICTQLLFPIFGILS--KHWEVNQFNSHDDMSVWLSTTLIQALRNMVALFTHYFESLNG 1488
+ + L IF ILS + + ++ VW+ TT+++AL+ + L + FE L+
Sbjct: 1446 ETVSNKALLSIFSILSITNSQRLYLAKNTEETEVWMLTTMVEALKAFIELIKNLFERLHF 1505
Query: 1489 LLDGVLGLMVSCICQENDTIARIGRSCLQQLILQNMSEFNDTHWHQVTEAFSTLFQLTTA 1548
LL L L+ CICQEN I+++G SC Q +L+N ++F D W ++ + + L Q+T
Sbjct: 1506 LLPKALNLLEKCICQENSMISKVGLSCFSQFVLKNKNQFKDVDWDEIINSINQLLQMTLP 1565
Query: 1549 NELFESDPLKQGRRKSVPNTAGTDXXXXXXXXXXXXXXXXXXXXXXXXXXXXNGQDVGNE 1608
EL + Q N
Sbjct: 1566 IELRDPSLYPQ----------------------------------------------VNS 1579
Query: 1609 QGTISNGDIDALPPRRLVETKSTEELKQKVSVKNTIVVKCILQLLMIESLSELFEVEQFI 1668
++ + ++ P + S K K +IVVKC LQLLM+ L ELF + +
Sbjct: 1580 DSSLEDVKENSFRPHEISRFNSQSVFKSKKHHLKSIVVKCTLQLLMLNCLWELFHSDNML 1639
Query: 1669 NSIPFDEAIKLTTLLERSYEFARDFNDDYELRTRLVEARVSNKIPNLAKQETSSSAVLIN 1728
+IP + +KL +L++S+EFA FN D+E+R +++ + + +PNL QE + +
Sbjct: 1640 TNIPKRKMVKLLDILKQSWEFAESFNSDFEIRAKILSSGIVEHMPNLLSQEALCAKLYFY 1699
Query: 1729 ILFKLYLNRESSENGSTKEIKKNQKNLLQRLVGICVSIV----QRYVAMNDGVSERAANN 1784
F+ ++ S++ T+E + ++ Q+ + + +V QR + N +
Sbjct: 1700 TAFEC-MSSLKSDSHDTEEY-NDLMDVFQKKIYLASQLVLHGFQRVIGDN---PVKGVAA 1754
Query: 1785 WRPVIVEIIQGYSEFDDNDYKQQCKTMYDLILQIL 1819
++PVI ++ + D+ + + Y L+ I+
Sbjct: 1755 FQPVIAALVSYINSLDEIQFSRGKSEFYQLLCAIV 1789
>Hs5453573 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1785
Score = 640 bits (1651), Expect = 0.0
Identities = 442/1562 (28%), Positives = 750/1562 (47%), Gaps = 184/1562 (11%)
Query: 336 NDETERLVDEEENFQKPDDSITDEQALTI---------KDAFLLFRAMAKISAKPL-EDS 385
N +T + D+ ++ D+ +D Q + KDAFL+FR++ K+S KPL E
Sbjct: 334 NSQTNGIADDRQSLSSADNLESDAQGHQVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGP 393
Query: 386 LDMRSHVVRSKLLSLHTLHSILKDHIDVFLSQNVRVPGKEQVSLVHAVNQYLCLSLARNA 445
D +SH +RSK++SL L S+L++ VF + + ++A+ QYLC++L++N
Sbjct: 394 PDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEM---------FINAIKQYLCVALSKNG 444
Query: 446 ASPIAPVYEITLEIMWLIISNLRSEFKREIPVFLTDIYFPIADLKSSTNHQKRYFLSIIQ 505
S + V+E++L I ++SN + K +I VF +I+ I + +S+ + + +
Sbjct: 445 VSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLT 504
Query: 506 RVCNDPRTLIEFYLNYDCDSHMPNVVELIINYLTKLALTRVDVTTSQRAYYNDSLSKPLA 565
R+C D + +++ Y+NYDCD + N+ E ++N L+K+A R ++ PL
Sbjct: 505 RICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSG---------HELGMTPLQ 555
Query: 566 TFSYTQVXXXXXXXXXXXXXXXXXXFPVDYALKQMALTCMVAFLTSLSSWAHKALNSSSI 625
S L++ L C+V+ L + W+ K L +
Sbjct: 556 ELS----------------------------LRKKGLECLVSILKCMVEWS-KDLYVNPN 586
Query: 626 NTVGSSQSKALSQRADSSTLLSSNRPRSTSALXXXXXXXXXXXXXXXXXXXXXDPLQFET 685
+ Q + Q L R S +++ DP QFE
Sbjct: 587 HQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTVQD-------DPEQFEV 639
Query: 686 AKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLG 745
K +K + + ++LFN K K+GI ++G + S IA++L + LD + VG++LG
Sbjct: 640 IKQQKEIIEHGIELFNKKPKRGIQFLQEQGML-GTSVEDIAQFLHQEERLDSTQVGDFLG 698
Query: 746 EGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVD--Q 803
+ N +M+A+VDQ +F VSALR FL+ FRLPGE QKIDR M KFA R+++ Q
Sbjct: 699 DSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQ 758
Query: 804 NPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQI 863
+F+ ADTAYVLAYSII+L TDLHS Q+K KMT E++I+ N GI++ KDLP EY+ I
Sbjct: 759 GQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSI 818
Query: 864 FEEISNHEIKLLSEQHQAMISGDATAALPQQSSFGFFNGKDYEREAYIQVSKQISSKTEL 923
+EEI +I + + + AT + Q + + +R + + +KT
Sbjct: 819 YEEIEGKKIAMKETKELTI----ATKSTKQNVA------SEKQRRLLYNLEMEQMAKTAK 868
Query: 924 VFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIETSDLCLKGIKTS 983
+ + +A+H++HV+ +F+ +W LAA + + +D E + LCL+GI+ +
Sbjct: 869 ALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCA 928
Query: 984 IKIAATFGIDYARASFVGALIQFANL---QNLEEIKIKNVYAIITLLEIAVSEGNYMKDS 1040
I+IA FG+ R ++V AL +F+ L ++ ++K KN+ I TL+ +A ++GNY+ +S
Sbjct: 929 IRIACIFGMQLERDAYVQALARFSLLTASSSITKMKQKNIDTIKTLITVAHTDGNYLGNS 988
Query: 1041 WKDILVIVSQVERLQLISKGVDRETVPDVTQAR---LANHXXXXXXXXXXXXQNFFDRWT 1097
W +IL +SQ+E QLI GV + + R L H N
Sbjct: 989 WHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGV 1048
Query: 1098 RKATPGEIAQEKHYNQTLSPNISKFITSSELVVLIDKIFTNSSALSGSAIVDFIKALTEV 1157
K Q + +++ +S +VV +D+IFT S+ L G+AIVDF++ L V
Sbjct: 1049 NK------RQMASFQESVGET-----SSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAV 1097
Query: 1158 SFEEIESSQNATTPRMFSLQKMVDVCYYNMDRIRLEWTPIWNVMGEAFNRIATESNLAVV 1217
S +E+ S + PRMFSLQK+V++ YYNM+RIRL+W+ IW+V+G+ FN++ N V
Sbjct: 1098 SMDELASPHH---PRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVA 1154
Query: 1218 FFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPFEHTVENTRDIDVQEMCIECFHNFILTK 1277
FA+DSLRQLSM+FL+ EL F FQ DFL+PFEH ++ R +++M I C + ++
Sbjct: 1155 IFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQ 1214
Query: 1278 SGKIKSGWKPILKSLQYTAQSPNERIVTRTYELVSYDIVKDHFYXXXXXXXXXXXXXXXX 1337
+ I+SGWK I A + IV ++ + + +
Sbjct: 1215 AANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCL 1274
Query: 1338 KEITKNQKHQKLALHSLETLKRITNQVADLC-----FKNHDHQLLQGKDEFEDVWLPLLF 1392
E N ++ ++ ++ V++ + + D + G + W P+LF
Sbjct: 1275 SEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILF 1334
Query: 1393 CFNDTIMTAVDLEVRSRALNYMFDALVANGAEFDEEFWNKICTQLLFPIFGILSKHWEVN 1452
+ I+ L+VR+R L MF+ + + G F++ +W + +++F IF + +++
Sbjct: 1335 ELS-CIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDL-FRIVFRIFDNMKLPEQLS 1392
Query: 1453 QFNSHDDMSVWLSTTLIQALRNMVALFTHYFESLNG-LLDGVLGLMVSCICQENDTIARI 1511
+ S W++TT AL + +FT ++E+LN LL V + C+ Q+N+ +AR
Sbjct: 1393 ------EKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQLARS 1446
Query: 1512 GRSCLQQLILQNMSEFNDTHWHQVTEAFSTLFQLTTANELFESDPLKQGRRKSVPNTAGT 1571
G +CL+ L++ N +F+ W + +F+ T + L P+ S +
Sbjct: 1447 GTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKH---- 1502
Query: 1572 DXXXXXXXXXXXXXXXXXXXXXXXXXXXXNGQDVGNEQGTISNGDIDALPPRRLVETKST 1631
N + G Q +SN D+ R K
Sbjct: 1503 --------------LDVDLDRQSLSSIDKNPSERGQSQ--LSNPTDDSWKGRPYANQK-- 1544
Query: 1632 EELKQKVSVKNTIVVKCILQLLMIESLSELF----------------------------- 1662
+ ++++KC++QL +I+++ +
Sbjct: 1545 --------LFASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIE 1596
Query: 1663 -EVEQFINSIPFDEAIKLTTLLERSYEFARDFNDDYELRTRLVEARVSNKI-PNLAKQET 1720
E + + KL L+ S+ F++ FN +YE RT L A K PNL KQET
Sbjct: 1597 TEDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQET 1656
Query: 1721 SSSAVLINILFKLYLNRESSENGSTKEIKKNQKNLLQRLVGICVSIVQRYVAMNDGVSER 1780
SS A + ILF++Y+ + + S +EI+ QRL+ +C + ++ +N SE
Sbjct: 1657 SSLACCLRILFRMYV--DENRRDSWEEIQ-------QRLLTVCSEALAYFITVN---SES 1704
Query: 1781 AANNWRPVIVEIIQGYSEFDDNDYKQQCKTMYDLILQILDKPCPDDLRHVIRLFLTRTRD 1840
W +++ ++ + +D +K Y + +I+ +LR V+R F R
Sbjct: 1705 HREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRISV 1764
Query: 1841 IF 1842
++
Sbjct: 1765 VY 1766
Score = 102 bits (254), Expect = 6e-21
Identities = 69/232 (29%), Positives = 115/232 (48%), Gaps = 34/232 (14%)
Query: 82 MNNANIKSVVLFVKSTLESIMKSKELKK------LTSCQKDIERTLKSLEQ----TSAAP 131
M + KS +FV LE I+ KE+K+ +CQ ++ +E+ T+A P
Sbjct: 1 MQESQTKS--MFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPP 58
Query: 132 TGTSVEIDSLLVFEALRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVNPPDSMASND 191
+E D F C+SK + +LDC KL ++ + N PDS A
Sbjct: 59 KANFIEADKY--FLPFELACQSKSPRVVSTSLDCLQKLIAYGHITG----NAPDSGA--- 109
Query: 192 QNPENIGITPPPKQKLIDAVIDTICDCFEGENTDSRVELQVVRGLASCILIDEATSCVHG 251
P ++LID +++TIC CF+G TD V+LQ+++ L + + +H
Sbjct: 110 -----------PGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIE--IHE 156
Query: 252 ASLLKAIRQIYNIFIFSLHSSNQGIAQATLTQIVTTVFDRIDVKSLNQQRSL 303
++L+ +R YNI++ S + NQ A+ATLTQ++ +F R++ + L + R L
Sbjct: 157 GTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARRL 208
>Hs5453571 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1849
Score = 637 bits (1642), Expect = 0.0
Identities = 448/1544 (29%), Positives = 754/1544 (48%), Gaps = 188/1544 (12%)
Query: 365 KDAFLLFRAMAKISAKPLEDSL-DMRSHVVRSKLLSLHTLHSILKDHIDVFLSQNVRVPG 423
KDAFL+FR++ K+S KPL D D +SH +RSK+LSL L SIL++ +F + +
Sbjct: 421 KDAFLVFRSLCKLSMKPLSDGPPDPKSHELRSKILSLQLLLSILQNAGPIFRTNEM---- 476
Query: 424 KEQVSLVHAVNQYLCLSLARNAASPIAPVYEITLEIMWLIISNLRSEFKREIPVFLTDIY 483
++A+ QYLC++L++N S + V+E++L I ++SN ++ K +I VF +I+
Sbjct: 477 -----FINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIF 531
Query: 484 FPIADLKSSTNHQKRYFLSIIQRVCNDPRTLIEFYLNYDCDSHMPNVVELIINYLTKLAL 543
I + +S+ K + + R+C D +++++ Y+NYDCD + N+ E ++N L+K+A
Sbjct: 532 LYILETSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQ 591
Query: 544 TRVDVTTSQRAYYNDSLSKPLATFSYTQVXXXXXXXXXXXXXXXXXXFPVDYALKQMALT 603
R S+ L + ++ +L++ L
Sbjct: 592 GRG--------------SQELGMSNVQEL-----------------------SLRKKGLE 614
Query: 604 CMVAFLTSLSSWAH-KALNSSSINTVGSSQ--SKALSQRADSSTLLSSNRPRSTSALXXX 660
C+V+ + W+ + +N +S T+G + + +S+ T+ NR S ++L
Sbjct: 615 CLVSISKCMVEWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETI---NRYGSLNSLEST 671
Query: 661 XXXXXXXXXXXXXXXXXXDPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDD 720
+P QFE K +K + + LFN K K+GI ++G +
Sbjct: 672 SSSGIGSYSTQMSGTD--NPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGML-GT 728
Query: 721 SSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKF 780
+ IA++L + LD + VGE+LG+ ++ N +M+A+VDQ +F+ VSALR+FL+ F
Sbjct: 729 TPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGF 788
Query: 781 RLPGEGQKIDRFMLKFAERFVD--QNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMT 838
RLPGE QKIDR M KFA R+++ Q +F+ ADTAYVLAYSII+L TDLHS Q+K KMT
Sbjct: 789 RLPGEAQKIDRLMEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMT 848
Query: 839 LEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQHQAMISGDATAALPQQSSFG 898
E++I+ N GI++ KDLP EY+ I+ EI+ +I + + +P +SS
Sbjct: 849 KEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKE---------LTIPTKSSKQ 899
Query: 899 FFNGKDYEREAYIQVSKQISSKTELVFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLA 958
+ R Y +Q++ + + + +S + + +A+H+EHV+ +F+ W FLA
Sbjct: 900 NVASEKQRRLLYNLEMEQMAKTAKALMEAVS-HVQAPFTSATHLEHVRPMFKLAWTPFLA 958
Query: 959 ALTPPFKEYNDIETSDLCLKGIKTSIKIAATFGIDYARASFVGALIQFANL---QNLEEI 1015
A + ++ +D E + LCL+GI+ +I+IA F I R ++V AL +F L + E+
Sbjct: 959 AFSVGLQDCDDTEVASLCLEGIRCAIRIACIFSIQLERDAYVQALARFTLLTVSSGITEM 1018
Query: 1016 KIKNVYAIITLLEIAVSEGNYMKDSWKDILVIVSQVERLQLISKGVDRETVPDVTQARLA 1075
K KN+ I TL+ +A ++GNY+ +SW +IL +SQ++ QLI GV + + R
Sbjct: 1019 KQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLKLAQLIGTGVKPRYISGTVRGREG 1078
Query: 1076 NHXXXXXXXXXXXXQNFFDRWTRKATPGE------IAQEKHYNQTLSPNISKFITSSE-L 1128
+ T+ P E + + Q S S TSS+ +
Sbjct: 1079 SLTG-----------------TKDQAPDEFVGLGLVGGNVDWKQIASIQESIGETSSQSV 1121
Query: 1129 VVLIDKIFTNSSALSGSAIVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNMD 1188
VV +D+IFT S+ L G+AIVDF++ L VS +E+ S+ T PRMFSLQK+V++ YYNM
Sbjct: 1122 VVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELLST---THPRMFSLQKIVEISYYNMG 1178
Query: 1189 RIRLEWTPIWNVMGEAFNRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLK 1248
RIRL+W+ IW V+G+ FN++ N V FA+DSLRQLSM+FL+ EL F FQ DFL+
Sbjct: 1179 RIRLQWSRIWEVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLR 1238
Query: 1249 PFEHTVENTRDIDVQEMCIECFHNFILTKSGKIKSGWKPILKSLQYTAQSPNERIVTRTY 1308
PFEH ++ R +++M + C + +++ I+SGWK I A +E IV +
Sbjct: 1239 PFEHIMKRNRSPTIRDMVVRCIAQMVNSQAANIRSGWKNIFSVFHLAASDQDESIVELAF 1298
Query: 1309 ELVSYDIVKDHFYXXXXXXXXXXXXXXXXKEITKNQKHQKLALHSLETLKRITNQVAD-- 1366
+ + + E N ++ ++ ++ V+D
Sbjct: 1299 QTTGHIVTLVFEKHFPATIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRHCAKYVSDRP 1358
Query: 1367 LCFKNH---DHQLLQGKDEFEDVWLPLLFCFNDTIMTAVDLEVRSRALNYMFDALVANGA 1423
FK + D + + W P+LF + I+ L+VR+R L MF+ + G
Sbjct: 1359 QAFKEYTSDDMNVAPEDRVWVRGWFPILFELS-CIINRCKLDVRTRGLTVMFEIMKTYGH 1417
Query: 1424 EFDEEFWNKICTQLLFPIFGILSKHWEVNQFNSHDDMSVWLSTTLIQALRNMVALFTHYF 1483
+++ +W + +++F IF + + + W++TT AL + +FT Y
Sbjct: 1418 TYEKHWWQDL-FRIVFRIFD------NMKLPEQQTEKAEWMTTTCNHALYAICDVFTQYL 1470
Query: 1484 ESLNG-LLDGVLGLMVSCICQENDTIARIGRSCLQQLILQNMSEFNDTHWHQVTEAFSTL 1542
E L+ LLD + + C+ Q+N+ +AR G +CL+ +++ N +F W + +
Sbjct: 1471 EVLSDVLLDDIFAQLYWCVQQDNEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDI 1530
Query: 1543 FQLTTANELFESDPLKQGRRKSVPNTAGTDXXXXXXXXXXXXXXXXXXXXXXXXXXXXNG 1602
F+ T + L P G P + ++
Sbjct: 1531 FKTTIPHALLTWRP-NSGETAPPPPSPVSEKPLDTI-----------------------S 1566
Query: 1603 QDVGNEQGTISNGDIDALPPRRLVETKSTEELKQKV---------SVKNTIVVKCILQLL 1653
Q + +I +D P LV + E K+ + +++KC++QL
Sbjct: 1567 QKSVDIHDSIQPRSVDNRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIKCVVQLE 1626
Query: 1654 MIESLSELF---------EVEQFI----NSIPFD-----------------EAIKLTTLL 1683
+I+++ + + E +++ FD + KL L
Sbjct: 1627 LIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYRFLTSQQLFKLLDCL 1686
Query: 1684 ERSYEFARDFNDDYELRTRLVEARVSNKI-PNLAKQETSSSAVLINILFKLYLNRESSEN 1742
S+ FA+ FN + E RT L +A K PNL KQETSS A + ILF++Y+ + S
Sbjct: 1687 LESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYM--DESRV 1744
Query: 1743 GSTKEIKKNQKNLLQRLVGICVSIVQRYVAMNDGVSERAANNWRPVIVEIIQGYSEFDDN 1802
+ +E++ QRL+ +C + ++ + SE W +++ + + DN
Sbjct: 1745 SAWEEVQ-------QRLLNVCSEALSYFLTL---TSESHREAWTNLLLLFLTKVLKISDN 1794
Query: 1803 DYKQQCKTMYDLILQILDKPCPDDLRHVIRLFLTRTRDIFLDSE 1846
+K Y L+ +I+ +LR V+R F R +F S+
Sbjct: 1795 RFKAHASFYYPLLCEIMQFDLIPELRAVLRRFFLRIGVVFQISQ 1838
Score = 96.7 bits (239), Expect = 3e-19
Identities = 69/235 (29%), Positives = 114/235 (48%), Gaps = 39/235 (16%)
Query: 88 KSVVLFVKSTLESIMKSKELKKL------TSCQKDIERTLKSLEQTSA----APTGTSVE 137
K+ +F+ LE I+ KE+KK +C+ +E E+ S A G+S
Sbjct: 6 KTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTL 65
Query: 138 ---------IDSLLVFEALRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVNPPDSMA 188
I++ F C+SK I +LDC KL ++ L N PDS
Sbjct: 66 PPVKSKTNFIEADKYFLPFELACQSKCPRIVSTSLDCLQKLIAYGHLTG----NAPDSTT 121
Query: 189 SNDQNPENIGITPPPKQKLIDAVIDTICDCFEGENTDSRVELQVVRGLASCILIDEATSC 248
P +KLID +I+TIC CF+G TD V+LQ+++ L + +
Sbjct: 122 --------------PGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIE-- 165
Query: 249 VHGASLLKAIRQIYNIFIFSLHSSNQGIAQATLTQIVTTVFDRIDVKSLNQQRSL 303
+H ++L+A+R YNI++ S + NQ A+ATLTQ++ +F R++ ++L + + +
Sbjct: 166 IHEGTVLQAVRTCYNIYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQM 220
>7298092 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1643
Score = 634 bits (1636), Expect = 0.0
Identities = 441/1535 (28%), Positives = 737/1535 (47%), Gaps = 210/1535 (13%)
Query: 92 LFVKSTLESIMKSKELKKL------TSCQKDIERTLKSLEQTSAAPTGTSVE-------- 137
+F+ LE I+ K++++ SC +E+ L G +
Sbjct: 1 MFIVRALEKILADKDIRRSHHSQLKKSCDSALEQIKAELISAGQIAEGNELPCAALPLPK 60
Query: 138 ------IDSLLVFEALRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVNPPDSMASND 191
I++ F C+S+ I + ALDC KL ++ L S+ +
Sbjct: 61 NDAASIINAETYFLPFELACKSRSPRIVVTALDCLQKLIAYGHLTGSI---------QDS 111
Query: 192 QNPENIGITPPPKQKLIDAVIDTICDCFEGENTDSRVELQVVRGLASCILIDEATSCVHG 251
NP ++ LID ++ TI CF G TD V+LQ+++ L + + +H
Sbjct: 112 ANPGHL---------LIDRIVVTIYGCFSGPQTDEAVQLQIIKALLTVVTSQHVE--IHE 160
Query: 252 ASLLKAIRQIYNIFIFSLHSSNQGIAQATLTQIVTTVFDRID--VKSLNQQRSLSTISLK 309
+LL+A+R Y+I++ S + NQ A+ATLTQ++ +F R++ V L S T
Sbjct: 161 FTLLQAVRTCYDIYLSSKNLVNQTTARATLTQMLNVIFARMENQVYELPPPNSNPTNGSI 220
Query: 310 NAASTNGG--TSTPSSEHPLTLQNL-DTLNDETERLVDEEENFQKPDDSI--------TD 358
++ NG S S+ + + L + ++ + ++E+ +P+ ++ +D
Sbjct: 221 HSEDCNGSGEESLRDSDEVIASELLAEIISAAYNEAMKDQESVGEPEPTLNGNDYSSHSD 280
Query: 359 EQALTI-----------------KDAFLLFRAMAKISAKPLEDSL-DMRSHVVRSKLLSL 400
++ + KDAFL+FRA+ K+S KPL D D +SH +RSK+LSL
Sbjct: 281 HDSVELHSENDAVVTAKFTHILQKDAFLVFRALCKLSMKPLPDGHPDPKSHELRSKVLSL 340
Query: 401 HTLHSILKDHIDVFLSQNVRVPGKEQVSLVHAVNQYLCLSLARNAASPIAPVYEITLEIM 460
H L IL++ VF S + + A+ QYLC++L+ N S + V+E++L I
Sbjct: 341 HLLLLILQNAGPVFRSNEM---------FIMAIKQYLCVALSNNGVSLVPEVFELSLSIF 391
Query: 461 WLIISNLRSEFKREIPVFLTDIYFPIADLKSSTNHQKRYFLSIIQRVCNDPRTLIEFYLN 520
++SN + KR+I VF +I+ I + SS+ K + + R+C D +++++ Y+N
Sbjct: 392 VALLSNFKVHLKRQIEVFFKEIFLNILEANSSSFEHKWMVIQALTRICADAQSVVDIYVN 451
Query: 521 YDCDSHMPNVVELIINYLTKLALTRVDVTTSQRAYYNDSLSKPLATFSYTQVXXXXXXXX 580
YDCD N+ E ++N L+K+A R + S+
Sbjct: 452 YDCDFSAANLFERLVNDLSKIAQGRQALELGANPMQEKSM-------------------- 491
Query: 581 XXXXXXXXXXFPVDYALKQMALTCMVAFLTSLSSWAHKA-LNSSSINTVGSSQSKALSQR 639
+ L C+V+ L + W+ +N + QS +++
Sbjct: 492 -----------------RIRGLECLVSILKCMVEWSKDLYVNPNMPVPPMQVQSPTSTEQ 534
Query: 640 ADSSTLLSSNRPRSTSALXXXXXXXXXXXXXXXXXXXXXDPLQFETAKLRKTELLNCVKL 699
+ T + + S+ +L P E K+RK + ++L
Sbjct: 535 DQADTTIQTMHSGSSHSLNSNQEQLQDL------------PEALEERKMRKEVMETGIEL 582
Query: 700 FNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFV 759
FN K +KG+ + +++ + + IA+WL + LD + +G Y+GE ++ + +M A++
Sbjct: 583 FNRKPQKGV-QFLQEKQLLGATCGDIARWLHEDERLDKTVIGNYIGENDDHSKEVMCAYI 641
Query: 760 DQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNP--NVFSKADTAYVL 817
D F+F + +V+ALR L+ FRLPGE QKIDR M KFA R+ + NP +F ADT YVL
Sbjct: 642 DAFDFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQSADTVYVL 701
Query: 818 AYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGK-DLPREYMEQIFEEISNHEIKLLS 876
A+SII+L TDLHS Q+K KMT E++I+ N GI + K DLP EY+ I++EIS HEIK+ +
Sbjct: 702 AFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKMKN 761
Query: 877 EQHQAMISGDATAALPQQSSFGFFNGKDYEREAYIQVSKQISSKTELVFKNLSKNKDTVY 936
SG A P F K R+ + ++ S T + + +
Sbjct: 762 N------SGMLQQAKPTGKQ-AFITEK--RRKLLWNMEMEVISLTATNLMQSVSHVKSPF 812
Query: 937 YAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIETSDLCLKGIKTSIKIAATFGIDYAR 996
+A H+EHV+ +F+ W FLAA + ++ +D E + LCL GI+ +I+IA F + R
Sbjct: 813 TSAKHLEHVRPMFKMAWTPFLAAFSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLER 872
Query: 997 ASFVGALIQFANL---QNLEEIKIKNVYAIITLLEIAVSEGNYMKDSWKDILVIVSQVER 1053
++V AL +F L + E+K KN+ I TL+ +A ++GNY+ SW DI+ +SQ+E
Sbjct: 873 DAYVQALARFTLLNANSPINEMKAKNIDTIKTLIMVAHTDGNYLGSSWLDIVKCISQLEL 932
Query: 1054 LQLISKGVDRETVPDVTQARLANHXXXXXXXXXXXXQNFFDRWTRKATPGEIAQEKHYNQ 1113
QLI GV + + +
Sbjct: 933 AQLIGTGVRPQFLS--------------------------------------GAQTTLKD 954
Query: 1114 TLSPNISKFI---TSSELVVLIDKIFTNSSALSGSAIVDFIKALTEVSFEEIESSQNATT 1170
+L+P++ + I +S +VV +D+IFT S L G AIVDF+KAL +VS +E++ Q
Sbjct: 955 SLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALCQVSVDELQQQQ---- 1010
Query: 1171 PRMFSLQKMVDVCYYNMDRIRLEWTPIWNVMGEAFNRIATESNLAVVFFAIDSLRQLSMR 1230
PRMFSLQK+V++ YYNM+RIRL+W+ IW V+GE FN + SN + FFA+DSLRQLSM+
Sbjct: 1011 PRMFSLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFFALDSLRQLSMK 1070
Query: 1231 FLDIEELTGFEFQLDFLKPFEHTVENTRDIDVQEMCIECFHNFILTKSGKIKSGWKPILK 1290
F++ E + F FQ DFL+PFEH ++ +++M + C + +++ I+SGWK I
Sbjct: 1071 FMEKGEFSNFRFQKDFLRPFEHIMKKNASPAIRDMVVRCIAQMVNSQAHNIRSGWKNIFS 1130
Query: 1291 SLQYTAQSPNERIVTRTYELVSYDIVKDHFYXXXXXXXXXXXXXXXXKEITKNQKHQKLA 1350
A E IV ++ I+ D + + +
Sbjct: 1131 IFHLAAGDNEEPIVELAFQTTG-KIIGDLYKRQFAIMVDSFQDAVKCLSEFATARFPDTS 1189
Query: 1351 LHSLETLKRITNQV--ADLCFKNH-----DHQLLQGKDEFEDVWLPLLFCFNDTIMTAVD 1403
+ ++ ++ V A F H D + + + W P+LF + ++
Sbjct: 1190 MEAIRLVRTCAQCVHEAPQLFAEHAGMENDASVAEEDRVWVRGWFPMLFSLS-CVVNRCK 1248
Query: 1404 LEVRSRALNYMFDALVANGAEFDEEFWNKICTQLLFPIFGILSKHWEVNQFNSH-DDMSV 1462
L+VR+RAL +F+ + G F +W +F ++ + ++ + H + S
Sbjct: 1249 LDVRTRALTVLFEIVKTYGESFKPHWWK--------DLFNVIFRIFDNMKLPEHVTEKSE 1300
Query: 1463 WLSTTLIQALRNMVALFTHYFESLNG-LLDGVLGLMVSCICQENDTIARIGRSCLQQLIL 1521
W++TT AL ++ +FT YF+ L LL+ + + C+ Q N+ +AR G +CL+ L++
Sbjct: 1301 WMTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAQLHWCVQQSNEQLARSGTNCLENLVI 1360
Query: 1522 QNMSEFNDTHWHQVTEAFSTLFQLTTANELFESDP 1556
N +FN++ W + + +F T +L P
Sbjct: 1361 SNGFKFNESTWDKTCQCILDIFNATLPQDLLSWRP 1395
Score = 62.8 bits (151), Expect = 5e-09
Identities = 45/169 (26%), Positives = 79/169 (46%), Gaps = 13/169 (7%)
Query: 1675 EAIKLTTLLERSYEFARDFNDDYELRTRLVEARVSNKI-PNLAKQETSSSAVLINILFKL 1733
+ + L L +S+ FA+ FN D++ R+ L A + PNL KQETSS A ++ I FK+
Sbjct: 1481 QLLTLADCLMQSHRFAKRFNADHDQRSLLWRAGFKGSVKPNLLKQETSSLACVLRIFFKM 1540
Query: 1734 YLNRESSENGSTKEIKKNQKNLLQRLVGICVSIVQRYVAMNDGVSERAANNWRPVIVEII 1793
Y EN + + + Q LV +C + Y+++ SE + W +++ I+
Sbjct: 1541 Y----GDENR-----RSDWPGIEQELVQVCKEALGYYLSLQ---SEAHRDAWTSLLLLIL 1588
Query: 1794 QGYSEFDDNDYKQQCKTMYDLILQILDKPCPDDLRHVIRLFLTRTRDIF 1842
+ D + Y L+ +++ +LR V+R R +F
Sbjct: 1589 TRLLKMSDARFATHVSNYYSLLCEMMCFDLKPELRSVLRRVFMRIGPVF 1637
>At1g01960 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1750
Score = 589 bits (1519), Expect = e-167
Identities = 503/1874 (26%), Positives = 833/1874 (43%), Gaps = 323/1874 (17%)
Query: 98 LESIMKS----KELKKLTSCQKDIERTLKSLEQTSA---APTGTSVE------------- 137
L+ ++K+ K K C+ IER L+S E +S + +G+S+
Sbjct: 18 LDKVIKNASWRKHSKLAHECKSVIER-LRSPENSSPVADSESGSSIPGPLHDGGAAEYSL 76
Query: 138 IDSLLVFEALRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVNPPDSMASNDQNPENI 197
+S ++ L + + ++ I A+DC KL + + +P
Sbjct: 77 AESEIILSPLINASSTGVLKIVDPAVDCIQKLIAH-------------GYVRGEADP--- 120
Query: 198 GITPPPKQKLIDAVIDTICDCFEGENTDSRVELQVVRGLASCILIDEATSCVHGASLLKA 257
T P+ L+ +I+TIC C E + D +EL V++ L + + + +HG SLL+
Sbjct: 121 --TGGPEALLLSKLIETICKCHELD--DEGLELLVLKTLLTAVT--SISLRIHGDSLLQI 174
Query: 258 IRQIYNIFIFSLHSSNQGIAQATLTQIVTTVFDRIDVKSL------------------NQ 299
+R Y I++ S + NQ A+A+L Q+ VF R++ S ++
Sbjct: 175 VRTCYGIYLGSRNVVNQATAKASLVQMSVIVFRRMEADSSTVPIQPIVVAELMEPMDKSE 234
Query: 300 QRSLSTISLK-----------------NAASTNGG------TSTPSSEHPLTLQN----- 331
+T S++ NA T GG TS P + +P L +
Sbjct: 235 SDPSTTQSVQGFITKIMQDIDGVFNSANAKGTFGGHDGAFETSLPGTANPTDLLDSTDKD 294
Query: 332 -LDT-----------LNDETERLVDEEENFQKPDDSITDEQALTIKDAFLLFRAMAKISA 379
LD L L D E +K DDS +DAFL+FRA+ K+S
Sbjct: 295 MLDAKYWEISMYKSALEGRKGELADGE--VEKDDDSEVQIGNKLRRDAFLVFRALCKLSM 352
Query: 380 K--PLEDSLDMRSHVVRSKLLSLHTLHSILKDHIDVFLSQNVRVPGKEQVSLVHAVNQYL 437
K P ED ++R K+++L L +L++ VF + + + A+ QYL
Sbjct: 353 KTPPKEDP-----ELMRGKIVALELLKILLENAGAVFRTSD---------RFLGAIKQYL 398
Query: 438 CLSLARNAASPIAPVYEITLEIMWLIISNLRSEFKREIPVFLTDIYFPIADLKSSTN-HQ 496
CLSL +N+AS + +++++ I+ ++S R+ K EI VF I + + + + Q
Sbjct: 399 CLSLLKNSASNLMIIFQLSCSILLSLVSRFRAGLKAEIGVFFPMIVLRVLENVAQPDFQQ 458
Query: 497 KRYFLSIIQRVCNDPRTLIEFYLNYDCDSHMPNVVELIINYLTKLALTRVDVTTSQRAYY 556
K L + ++C D + L++ ++NYDCD + N+ E ++N L K A
Sbjct: 459 KMIVLRFLDKLCVDSQILVDIFINYDCDVNSSNIFERMVNGLLKTAQ------------- 505
Query: 557 NDSLSKPLATFSYTQVXXXXXXXXXXXXXXXXXXFPVDYALKQMALTCMVAFLTSLSSWA 616
P T + P + A+K A+ C+VA L S+ W
Sbjct: 506 ----GVPPGTVT-------------------TLLPPQEAAMKLEAMKCLVAVLRSMGDWV 542
Query: 617 HKALNSSSINTVGSSQSKALSQRADSSTLLSSNRPRSTSALXXXXXXXXXXXXXXXXXXX 676
+K L + S + + D + L + P
Sbjct: 543 NKQLR------LPDPYSAKMLEIVDRN-LEEGSHPVENGKGDGGHGGFERSDSQSELSSG 595
Query: 677 XXDPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLD 736
D L E + K EL + +FN K KKGI IK + DS IA +L + GL+
Sbjct: 596 NSDALAIEQRRAYKLELQEGISIFNQKPKKGIEFLIKANKV-GDSPEEIAAFLKDASGLN 654
Query: 737 LSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKF 796
+ +G+YLGE + ++ +MHA+VD FEF + A+R FL+ FRLPGE QKIDR M KF
Sbjct: 655 KTLIGDYLGEREDLSLKVMHAYVDSFEFQGMEFDEAIRAFLRGFRLPGEAQKIDRIMEKF 714
Query: 797 AERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLP 856
AERF NP FS ADTAYVLAYS+ILLNTD H+ +K KMT + FI NN GID+GKDLP
Sbjct: 715 AERFCKCNPKDFSSADTAYVLAYSVILLNTDAHNPMVKSKMTADGFIRNNRGIDDGKDLP 774
Query: 857 REYMEQIFEEISNHEIKL----LSEQHQAMISGDATAALPQQSSFGF-FNGKDYEREAYI 911
EY+ ++E IS +EIK+ L Q + + L + G D E
Sbjct: 775 EEYLRALYERISRNEIKMKDDGLGPQQKQPTNSSRLLGLDTILNIVVPRRGDDMNMETSD 834
Query: 912 QVSKQISSKTELVFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIE 971
+ + + + FK ++ ++VYYAAS V ++ + E W LAA + P + +D
Sbjct: 835 DLIRHMQER----FKEKARKSESVYYAASDVIILRFMVEVCWAPMLAAFSVPLDQSDDAV 890
Query: 972 TSDLCLKGIKTSIKIAATFGIDYARASFVGALIQFANLQNLEEIKIKNVYAIITLLEIAV 1031
+ LCL+G +I + + + R +FV +L +F +L + +IK KN+ AI ++++A
Sbjct: 891 ITTLCLEGFHHAIHVTSVMSLKTHRDAFVTSLAKFTSLHSPADIKQKNIEAIKAIVKLAE 950
Query: 1032 SEGNYMKDSWKDILVIVSQVERLQLISKGVDRETVPDVT----------QARLA--NHXX 1079
EGNY++D+W+ IL VS+ E L L+ +G PD T + LA N
Sbjct: 951 EEGNYLQDAWEHILTCVSRFEHLHLLGEGAP----PDATFFAFPQTESGNSPLAKPNSVP 1006
Query: 1080 XXXXXXXXXXQNFFDRWTRKATPGEIAQEKHYNQTLSPNISKFITSSELVVLI---DKIF 1136
Q R + G K N S ++ I++ L+ + +IF
Sbjct: 1007 AIKERAPGKLQYAASAMIRGSYDGSGVAGKASNTVTSEQMNNLISNLNLLEQVGDMSRIF 1066
Query: 1137 TNSSALSGSAIVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNMDRIRLEWTP 1196
T S L+ AI+DF+KAL +VS +E+ S + PR+FSL K+V++ +YNM+RIRL W+
Sbjct: 1067 TRSQRLNSEAIIDFVKALCKVSMDELRSPSD---PRVFSLTKIVEIAHYNMNRIRLVWSS 1123
Query: 1197 IWNVMGEAFNRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPFEHTVEN 1256
IW+V+ + F I NL++ FA+DSLRQLSM+FL+ EEL + FQ +F+KPF +
Sbjct: 1124 IWHVLSDFFVTIGCSDNLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMKPFVVVMRK 1183
Query: 1257 TRDIDVQEMCIECFHNFILTKSGKIKSGWKPILKSLQYTAQSPNERIVTRTYELVSYDIV 1316
+ ++++E+ I C +L++ +KSGWK + A ++ IV ++E+V I+
Sbjct: 1184 SGAVEIRELIIRCVSQMVLSRVDNVKSGWKSMFMIFTTAAHDAHKNIVFLSFEMVE-KII 1242
Query: 1317 KDHFYXXXXXXXXXXXXXXXXKEITKNQKHQK-LALHSLETLKRITNQVAD--------- 1366
+D+F N K +K ++L ++ L+ ++A+
Sbjct: 1243 RDYFPHITETETTTFTDCVNCLVAFTNCKFEKDISLQAIAFLQYCARKLAEGYVGSSLRR 1302
Query: 1367 ---------LCFKNHDHQLLQGKDEFEDVWLPLLFCFNDTIMTAVDLEVRSRALNYMFDA 1417
K + L+ DE W PLL ++ + E+R AL +FD
Sbjct: 1303 NPPLSPQGGKIGKQDSGKFLE-SDEHLYSWFPLLAGLSE-LSFDPRAEIRKVALKVLFDT 1360
Query: 1418 LVANGAEFDEEFWNKICTQLLFPIFGILSKHWEVNQ--------FNSHDDMSVWLSTTLI 1469
L +G F W ++ +LF IF + + + ++ +N D WL T
Sbjct: 1361 LRNHGDHFSLALWERVFESVLFRIFDYVRQDVDPSEDDSTDQRGYNGEVDQESWLYETCS 1420
Query: 1470 QALRNMVALFTHYFESLNGLLDGVLGLMVSCICQENDTIARIGRSCLQQLILQNMSEFND 1529
AL+ +V LF ++++++N LL VL L VS I + + ++A G + L +L+ +F++
Sbjct: 1421 LALQLVVDLFVNFYKTVNPLLKKVLMLFVSLIKRPHQSLAGAGIAALVRLMRDVGHQFSN 1480
Query: 1530 THWHQV-------TEAFSTLFQLTTANELFESDPLKQGRRKSVPNTAGTDXXXXXXXXXX 1582
W +V +A S F T+ +L E
Sbjct: 1481 EQWLEVVSCIKEAADATSPDFSYVTSEDLME----------------------------- 1511
Query: 1583 XXXXXXXXXXXXXXXXXXNGQDVGNEQGTISNGDIDALPPRRLVETKSTEELKQKVSVKN 1642
DV NE T N + DAL R + K K S+
Sbjct: 1512 ---------------------DVSNEDETNDNSN-DALRRRNRQLHAVVTDAKSKASI-- 1547
Query: 1643 TIVVKCILQLLMIESLSELFEVEQFINSIPFDEAIKLTTLLERSYEFARDFNDDYELRTR 1702
Q+ +I+++++++++ + S+ + + L + A N D LR++
Sbjct: 1548 --------QIFVIQAVTDIYDMYRM--SLTANHMLMLFDAMHGIGSNAHKINADLLLRSK 1597
Query: 1703 LVE--ARVSNKIPNLAKQETSSSAVLINILFKLYLNRESSENGSTKEIKKNQKNLLQRLV 1760
L E + + ++ L + E S + L L S + + N+ + L+
Sbjct: 1598 LQELGSSLESQEAPLLRLENESFQTCMTFLDNLI---------SDQPVGYNEAEIESHLI 1648
Query: 1761 GICVSIVQRYVAMNDGVSERAANNW---------------RPVIVEIIQGYSEFDDNDYK 1805
+C +++ Y+ N S+ ++ W P++V IQ ++ +K
Sbjct: 1649 SLCREVLEFYI--NISCSKEQSSRWAVPSGSGKKKELTARAPLVVAAIQTLGNMGESLFK 1706
Query: 1806 QQCKTMYDLILQIL 1819
+ ++ LI ++
Sbjct: 1707 KNLPELFPLIATLI 1720
>At3g60860 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1793
Score = 585 bits (1509), Expect = e-166
Identities = 497/1897 (26%), Positives = 835/1897 (43%), Gaps = 317/1897 (16%)
Query: 94 VKSTLESIMKS----KELKKLTSCQKDIERTLKSLEQT----SAAPT------------- 132
V LE I+K+ K K C+ IER L SL+++ S+A T
Sbjct: 14 VTPALEKIVKNASWRKHSKLANECKAVIER-LNSLQKSPPPSSSAATDSESESSVPGPLN 72
Query: 133 -GTSVEI---DSLLVFEALRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVNPPDSMA 188
G S+E DS L+F L + C + + I A+DC KL + +
Sbjct: 73 DGGSIEYSLADSELIFSPLINACGTGLAKIIEPAIDCIQKLIAHGYI------------- 119
Query: 189 SNDQNPENIGITPPPKQKLIDAVIDTICDCFEGENTDSRVELQVVRGLASCILIDEATSC 248
+ +P + L+ +ID++C C + D +EL V++ L S I + +
Sbjct: 120 RGESDPSG-----GAESLLLFKLIDSVCKCHD--LGDESIELPVLKTLLSAI--NSISLR 170
Query: 249 VHGASLLKAIRQIYNIFIFSLHSSNQGIAQATLTQIVTTVFDRID------------VKS 296
+HG LL +R Y+I++ S + NQ A+A+L QI+ VF R++ V
Sbjct: 171 IHGKCLLLVVRTCYDIYLGSKNVVNQTTAKASLIQILVIVFRRMEADSSTVPIQPIVVAE 230
Query: 297 LNQQRSLS---------------------------TISLKNAASTNGGTSTPSSEHPLTL 329
L + S T+S + S +GG +
Sbjct: 231 LMEPLEKSDADGTMTQFVQGFITKIMQDIDGVLNPTMSGSGSGSGSGGQDGAYGTTTVET 290
Query: 330 QNLDTLNDETER-LVDE--------------------EENFQKPDDSITDEQALTIKDAF 368
N L D T++ ++D + + ++ DD + +DA
Sbjct: 291 TNPTDLLDSTDKDMLDAKYWEISMYKSALEGRKGELTDGDAERDDDLEVQIENKLRRDAC 350
Query: 369 LLFRAMAKISAK--PLEDSLDMRSHVVRSKLLSLHTLHSILKDHIDVFLSQNVRVPGKEQ 426
L+FRA+ K+S K P E S D +S +R K+L+L L +L++ VF + E+
Sbjct: 351 LVFRALCKLSMKAPPKESSADPQS--MRGKILALELLKILLENAGAVFRTS-------EK 401
Query: 427 VSLVHAVNQYLCLSLARNAASPIAPVYEITLEIMWLIISNLRSEFKREIPVFLTDIYFPI 486
S + Q+LCLSL +N+AS + +++++ I +++ R+ K EI VF I +
Sbjct: 402 FSA--DIKQFLCLSLLKNSASTLMIIFQLSCSIFISLVARFRAGLKAEIGVFFPMIVLRV 459
Query: 487 ADLKSSTN-HQKRYFLSIIQRVCNDPRTLIEFYLNYDCDSHMPNVVELIINYLTKLALTR 545
+ + N QK L + ++C D + L++ +LNYDCD + N+ E ++N L K A
Sbjct: 460 VENVAQPNFQQKMIVLRFLDKLCLDSQILVDIFLNYDCDVNSSNIFERMVNGLLKTAQ-- 517
Query: 546 VDVTTSQRAYYNDSLSKPLATFSYTQVXXXXXXXXXXXXXXXXXXFPVDYALKQMALTCM 605
P T + P + A+K A+ C+
Sbjct: 518 ---------------GVPPGTATTLMP-------------------PQEAAMKLEAMKCL 543
Query: 606 VAFLTSLSSWAHKALNSSSINTVGSSQSKALSQRADSSTLLSSNRPRSTSALXXXXXXXX 665
VA L S+ W +K L N++ S + S L + N S
Sbjct: 544 VAILKSMGDWLNKQLRLPVSNSLNKSDVIEIDLGPGSPQLANGNADESADG--------- 594
Query: 666 XXXXXXXXXXXXXDPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAI 725
D L E + K EL + LFN K KGI I G + +S I
Sbjct: 595 -SDTYSESSGGTSDALAIEQRRAYKLELQEGISLFNRKPTKGIEFLINAGKV-GESPEEI 652
Query: 726 AKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGE 785
A +L + GL+ + +G+YLGE + + +MHA+VD F+F + A+R FL+ FRLPGE
Sbjct: 653 AGFLKDASGLNKTLIGDYLGEREDLALKVMHAYVDSFDFRGMEFDEAIRTFLEGFRLPGE 712
Query: 786 GQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIEN 845
QKIDR M KFAER+ NP VF+ AD+AYVLAYS+I+LNTD H+ +K KM+ ++FI N
Sbjct: 713 AQKIDRIMEKFAERYCKCNPKVFTSADSAYVLAYSVIMLNTDAHNPMVKNKMSADDFIRN 772
Query: 846 NSGIDNGKDLPREYMEQIFEEISNHEIKLLSE--QHQAMISGDATAALPQQSSFGFFNGK 903
N GID+GKDLP +YM ++E I+ HEIK+ + + Q ++ L K
Sbjct: 773 NRGIDDGKDLPADYMRSLYERITKHEIKMKEDDLRLQQKQYANSNRMLGLDGILNIVIRK 832
Query: 904 DYEREAYIQVSKQISSKTELVFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPP 963
+ ++Y + S + + FK ++ ++ YYAA+ V ++ + E W LAA + P
Sbjct: 833 QW-GDSYAETSDDLMKHMQEQFKEKARKSESTYYAATDVVILRFMIEACWAPMLAAFSVP 891
Query: 964 FKEYNDIETSDLCLKGIKTSIKIAATFGIDYARASFVGALIQFANLQNLEEIKIKNVYAI 1023
+ +D+ ++CL+G +I + + R +FV +L +F +L + +IK +N+ AI
Sbjct: 892 LDQSDDLIVINICLEGFHHAIHATSLMSMKTHRDAFVTSLAKFTSLHSPADIKQRNIEAI 951
Query: 1024 ITLLEIAVSEGNYMKDSWKDILVIVSQVERLQLISKGVDRETVPDVTQARLANHXXXXXX 1083
+L +A EGNY++D+W+ IL VS+ E+L L+ +G + ++ +
Sbjct: 952 KAILRLADEEGNYLQDAWEHILTCVSRFEQLHLLGEGAPPDATFFASKQNESEKSKQPKQ 1011
Query: 1084 XXXXXXQNFFDRWTRKATPGEI-----------AQEKHYNQTLSPNISKFITSSELVVLI 1132
+ ++ A G + K+ Q +I + E V +
Sbjct: 1012 YILPVLKRKGPGKSQYAATGVLRGSYDSMSLGGKGSKNVRQEQMSSIVSNLNLLEQVGEM 1071
Query: 1133 DKIFTNSSALSGSAIVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNMDRIRL 1192
+++F+ S L+ AI+DF+KAL +VS +E+ S N PR+FSL K+V++ +YNM+RIRL
Sbjct: 1072 NQVFSQSQKLNSEAIIDFVKALCKVSMDELRSPSN---PRVFSLTKIVEIAHYNMNRIRL 1128
Query: 1193 EWTPIWNVMGEAFNRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPFEH 1252
W+ IW V+ F I NL++ FA+DSLRQLSM+FL+ EEL + FQ +F+ PF
Sbjct: 1129 VWSSIWQVLSGFFVTIGCSENLSIAIFAMDSLRQLSMKFLEREELANYNFQNEFMTPFVI 1188
Query: 1253 TVENTRDIDVQEMCIECFHNFILTKSGKIKSGWKPILKSLQYTAQSPNERIVTRTYELVS 1312
+ + D++++E+ I C +L++ +KSGWK + A ++ IV ++E++
Sbjct: 1189 VMRRSNDVEIRELIIRCVSQMVLSRVNNVKSGWKSMFMVFTTAAYDDHKNIVFLSFEIIE 1248
Query: 1313 YDIVKDHF-YXXXXXXXXXXXXXXXXKEITKNQKHQKLALHSLETLKRITNQVADLCFKN 1371
I++++F Y T N+ + ++L S+ L+ ++A+ +
Sbjct: 1249 -KIIREYFPYITETETTTFTDCVNCLVAFTNNRFSKDISLSSIAFLRYCATKLAEGDLNS 1307
Query: 1372 HD----------------HQLLQGKDEFEDV--------WLPLLFCFNDTIMTAVDLEVR 1407
H GK E ++ W PLL ++ E+R
Sbjct: 1308 PSTNKYKGTSGKIPQSSLHSGKSGKQENGEIVNNNHLYFWFPLLSGLSELSFDPRP-EIR 1366
Query: 1408 SRALNYMFDALVANGAEFDEEFWNKICTQLLFPIFGIL----------------SKHWEV 1451
AL MFD L +G F W K+ +LFPIF + S EV
Sbjct: 1367 KSALQIMFDTLRNHGHLFSLPLWEKVFESVLFPIFDYVRHSIDPSGEDESADQGSSGGEV 1426
Query: 1452 NQFNSHDDMSVWLSTTLIQALRNMVALFTHYFESLNGLLDGVLGLMVSCICQENDTIARI 1511
++ D WL T AL+ +V LF ++ ++N LL+ VL L+VS I + + ++A I
Sbjct: 1427 DEL----DHDAWLYETCTLALQLVVDLFVKFYTTVNPLLEKVLMLLVSFIKRPHQSLAGI 1482
Query: 1512 GRSCLQQLILQNMSEFNDTHWHQVTEAFSTLFQLTTAN-ELFESDPLKQGRRKSVPNTAG 1570
G + +L+ F++ W +V A + T + F S+ ++S N
Sbjct: 1483 GIAAFVRLMSDADGLFSEEKWLEVVSALKEAAKTTCPDFSYFLSEEYVARSQRSALN--- 1539
Query: 1571 TDXXXXXXXXXXXXXXXXXXXXXXXXXXXXNGQDVGNEQGTISNGDIDALPPRRLVETKS 1630
I N + ++ P T
Sbjct: 1540 -----------------------------------------IQNSNAESAAP---TATDG 1555
Query: 1631 TEELKQKVSVKNTIV--VKC--ILQLLMIESLSELFEVEQFINSIPFDEAIKLTTLLERS 1686
EE ++ + + KC +QLL+I+++ E++ + + + + L L
Sbjct: 1556 NEESQRTATHLYAAISDAKCRAAVQLLLIQAVMEIYNM--YRPQLSAKNTLVLVDALHGV 1613
Query: 1687 YEFARDFNDDYELRTRLVEARVSNKI--PNLAKQETSSSAVLINILFKLYLNRESSENGS 1744
A N + LR+RL E ++ P L + E S + + L L ++ +
Sbjct: 1614 ALHAHGINSNTILRSRLQELGPMTQMQDPPLLRLENESYQICLTFLQNLVADK------T 1667
Query: 1745 TKEIKKNQKNLLQRLVGICVSIVQRYVAMNDGV------SERAAN-NWR----------- 1786
KE ++ ++ + LV IC ++ Y+ + S RA+ WR
Sbjct: 1668 KKEEEEEEEEIESLLVNICQEVLNFYIETSSSAKKLQSESSRASEYRWRIPLGSGKRREL 1727
Query: 1787 ----PVIVEIIQGYSEFDDNDYKQQCKTMYDLILQIL 1819
P+IV +Q D+ +++ K ++ L+ ++
Sbjct: 1728 SARAPLIVATLQAMCTLDEASFEKNLKCLFPLLANLI 1764
>At4g38200 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1698
Score = 538 bits (1387), Expect = e-152
Identities = 419/1518 (27%), Positives = 712/1518 (46%), Gaps = 160/1518 (10%)
Query: 97 TLESIMKSKELKKLTSCQKDIERTLKSLEQTSAAPTGTS-----VEIDSLLVFEALRSCC 151
+L+ I+K+ +K T + L LE S +P +S D+ V + L
Sbjct: 20 SLDKIIKNAAWRKHTFLVSACKSVLDKLEALSDSPDPSSPLFGLTTSDADAVLQPLLLSL 79
Query: 152 RSKIIDIQIKALDCFAKLFSFQALDESLLVNPPDSMASNDQNPENIGITPPPKQKLIDAV 211
+ + ALDC KLFS L + + PDS+ KLI A+
Sbjct: 80 DTGYAKVIEPALDCSFKLFSLSLLRGEVCSSSPDSLL----------------YKLIHAI 123
Query: 212 IDTICDCFEGENTDSRVELQVVRGLASCILIDEATSCVHGASLLKAIRQIYNIFIFSLHS 271
C GE + +EL V+R L + + + G LL +R YN+++ +
Sbjct: 124 CKV---CGIGEES---IELAVLRVLLAAVRSPRIL--IRGDCLLHLVRTCYNVYLGGFNG 175
Query: 272 SNQGIAQATLTQIVTTVFDRIDVKSLNQQRSLSTISLKNA-ASTNGGTSTPSSEHPLTLQ 330
+NQ A++ L QI+ VF R + S++ SL T+++ + A T+ + +S H
Sbjct: 176 TNQICAKSVLAQIMLIVFTRSEANSMDA--SLKTVNVNDLLAITDKNVNEGNSVHICQGF 233
Query: 331 NLDTLNDETERLVDEEENFQKPDD--SITDEQALTIK---DAFLLFRAMAKISAKPLEDS 385
D + + Q P++ S T+++ K D FLLF+ + K+S K
Sbjct: 234 INDVITAGEAAPPPDFALVQPPEEGASSTEDEGTGSKIREDGFLLFKNLCKLSMKFSSQE 293
Query: 386 LDMRSHVVRSKLLSLHTLHSILKDHIDVFLS--QNVRVPGKEQVSLVHAVNQYLCLSLAR 443
+VR K LSL L I+ + ++LS + + +P ++ ++A+ Q LCLSL +
Sbjct: 294 NTDDQILVRGKTLSLELLKVIIDNGGPIWLSDERQLTLPPQKICRFLNAIKQLLCLSLLK 353
Query: 444 NAASPIAPVYEITLEIMWLIISNLRSEFKREIPVFLTDIYFPIADLKSSTNH------QK 497
N+A + ++++ I ++ RS K E+ +F FP+ L+ N QK
Sbjct: 354 NSALSVMSIFQLQCAIFTTLLRKYRSGMKSEVGIF-----FPMLVLRVLENVLQPSFVQK 408
Query: 498 RYFLSIIQRVCNDPRTLIEFYLNYDCDSHMPNVVELIINYLTKLALTRVDVTTSQRAYYN 557
LS+++ +C+DP +I+ ++N+DCD PN+ E I+N L K AL +++
Sbjct: 409 MTVLSLLENICHDPNLIIDIFVNFDCDVESPNIFERIVNGLLKTALGPPPGSST------ 462
Query: 558 DSLSKPLATFSYTQVXXXXXXXXXXXXXXXXXXFPVDYALKQMALTCMVAFLTSLSSWAH 617
+ P+ D + ++ C+V+ + ++ +W
Sbjct: 463 --ILSPVQ----------------------------DITFRHESVKCLVSIIKAMGTWMD 492
Query: 618 KALNSSSINTVGSSQ-SKALSQRADSSTLLSSNRPRSTSALXXXXXXXXXXXXXXXXXXX 676
+ L+ VG S K+L A ++ +SN T+
Sbjct: 493 QQLS------VGDSLLPKSLENEAPANNHSNSNEEDGTTI---------DHDFHPDLNPE 537
Query: 677 XXDPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLD 736
D E + K E V LFN K KGI I + +S + +L NT GL+
Sbjct: 538 SSDAATLEQRRAYKIERQKGVTLFNRKPSKGIEFLISSKKV-GNSPDEVVSFLRNTTGLN 596
Query: 737 LSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKF 796
+ +G+YLGE + + +MHA+VD F+F ++ A+R FL+ FRLPGE QKIDR M KF
Sbjct: 597 ATMIGDYLGEREDFPMKVMHAYVDSFDFKEMNFGEAIRFFLRGFRLPGEAQKIDRIMEKF 656
Query: 797 AERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLP 856
AERF NPN FS ADTAYVLAYS+I+LNTD H+ +K+KMT +FI NN GID+GKDLP
Sbjct: 657 AERFCKCNPNSFSSADTAYVLAYSVIMLNTDAHNIMVKEKMTKADFIRNNRGIDDGKDLP 716
Query: 857 REYMEQIFEEISNHEIKLLSEQH--QAMISGDATAALPQQSSFGFFNGKDYEREAYIQVS 914
EY+ +++++ +EIK+ S+ ++ S L E +A + +
Sbjct: 717 EEYLGALYDQVVINEIKMSSDSSAPESRQSNGLNKLLGLDGILNLVYWTQTEEKA-VGAN 775
Query: 915 KQISSKTELVFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIETSD 974
+ + F++ S ++ Y+ + V ++ + E W LAA + + +D +
Sbjct: 776 GLLIKDIQEKFRSKSGKSESAYHVVTDVAILRFMVEVSWGPMLAAFSVTLDQSDDRLAAV 835
Query: 975 LCLKGIKTSIKIAATFGIDYARASFVGALIQFANLQNLEEIKIKNVYAIITLLEIAVSEG 1034
CL+G + ++ + A G+ R +FV ++ +F NL ++K KNV A+ ++ IA+ +G
Sbjct: 836 ECLRGFRYAVHVTAVMGMQTQRDAFVTSMAKFTNLHCAGDMKQKNVDAVKAIISIAIEDG 895
Query: 1035 NYMKDSWKDILVIVSQVERLQLISKGVDRE-TVPDVTQARLANHXXXXXXXXXXXXQN-- 1091
N+++D+W+ IL +S++E LQL+ +G + + T+ QN
Sbjct: 896 NHLQDAWEHILTCLSRIEHLQLLGEGAPSDASYFASTETEEKKALGFPNLKKKGALQNPV 955
Query: 1092 --------FFDRWT-RKATPGEIAQEKHYNQTLSPNISKFITSSELVVLIDKIFTNSSAL 1142
+D T PG + Q++ N + N+ I S +L + ++ +S L
Sbjct: 956 MMAVVRGGSYDSSTIGPNMPGLVKQDQINNFIANLNLLDQIGSFQL----NNVYAHSQRL 1011
Query: 1143 SGSAIVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNMDRIRLEWTPIWNVMG 1202
AIV F+KAL +VS E+ Q+ T PR+FSL K+V++ +YNM+RIRL W+ IW+++
Sbjct: 1012 KTEAIVAFVKALCKVSMSEL---QSPTDPRVFSLTKLVEIAHYNMNRIRLVWSRIWSILS 1068
Query: 1203 EAFNRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPFEHTVENTRDIDV 1262
+ F + NL+V F +DSLRQLSM+FL+ EEL + FQ +FL+PF ++ + ++
Sbjct: 1069 DFFVSVGLSENLSVAIFVMDSLRQLSMKFLEREELANYNFQNEFLRPFVIVMQKSSSAEI 1128
Query: 1263 QEMCIECFHNFILTKSGKIKSGWKPILKSLQYTAQSPNERIVTRTYELVSYDIVKDHF-Y 1321
+E+ + C +L++ +KSGWK + K A + IV +E + IV+++F Y
Sbjct: 1129 RELIVRCISQMVLSRVSNVKSGWKSVFKVFTTAAADERKNIVLLAFETME-KIVREYFSY 1187
Query: 1322 XXXXXXXXXXXXXXXXKEITKNQKHQKLALHSLETLKRITNQVAD--LCFK--------- 1370
T + ++L+++ L+ ++AD L +
Sbjct: 1188 ITETEATTFTDCVRCLITFTNSTFTSDVSLNAIAFLRFCALKLADGGLVWNEKGRSSSPS 1247
Query: 1371 ---NHDH----QLLQGKDEFEDVWLPLLFCFNDTIMTAVDLEVRSRALNYMFDALVANGA 1423
DH Q DE W+PLL + + + +R +L +F+ L +G
Sbjct: 1248 TPVTDDHSPSTQNFMDADENISYWVPLLTGLS-KLTSDSRSAIRKSSLEVLFNILKDHGH 1306
Query: 1424 EFDEEFWNKICTQLLFPIFG-------ILSKHWE---VNQFNSHDDMSVWLSTTLIQALR 1473
F FW + + +++PIF +LSK + F+SH W + T A +
Sbjct: 1307 IFSRTFWIGVFSSVIYPIFNSVWGENDLLSKDEHSSFPSTFSSHPSEVSWDAETSAMAAQ 1366
Query: 1474 NMVALFTHYFESLNGLLDGVLGLMVSCICQ--ENDTIARIGRSCLQQLILQNMSEFNDTH 1531
+V LF +F + L V+ L+ I + T+A +G L +L + F++
Sbjct: 1367 YLVDLFVSFFTVIRSQLSSVVSLLAGLIRSPAQGPTVAGVG--ALLRLADELGDRFSENE 1424
Query: 1532 WHQVTEAFSTLFQLTTAN 1549
W ++ A + LT ++
Sbjct: 1425 WKEIFLAVNEAASLTLSS 1442
>At4g35380 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1711
Score = 500 bits (1288), Expect = e-141
Identities = 410/1533 (26%), Positives = 686/1533 (44%), Gaps = 176/1533 (11%)
Query: 97 TLESIMKSKELKKLT----SCQKDIERTLKSLEQTSAAPTGT-----SVEIDSLLV-FEA 146
+L+ I+K+ +K T SC+ +++ L+SL P+ + + DS+L F
Sbjct: 20 SLDKIIKNAAWRKHTYLVSSCKSVLDK-LESLPDDFHDPSSVVSGLAASDADSVLQPFLL 78
Query: 147 LRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVNPPDSMASNDQNPENIGITPPPKQK 206
SK+++ +LDC KLFS L + + DS+ K
Sbjct: 79 SLETAYSKVVE---PSLDCAFKLFSLSILRGEIQSSKQDSILF----------------K 119
Query: 207 LIDAVIDTICDCFEGENTDSRVELQVVRGLAS-----CILIDEATSCVHGASLLKAIRQI 261
L++AV G + ++L V+R L + CILI G LL ++
Sbjct: 120 LVNAVSKV------GAIAEEPIQLAVLRVLLAAVRSPCILI-------RGDCLLHVVKTC 166
Query: 262 YNIFIFSLHSSNQGIAQATLTQIVTTVFDRIDVKSLNQQRSLSTISLKNAA-----STNG 316
YNI++ L + Q A++ L Q++ +F R + SL+ S+ TI + S N
Sbjct: 167 YNIYLGGLSGTTQICAKSVLAQMMLVIFTRSEEDSLDV--SVKTIYVNELLTFTDKSVNE 224
Query: 317 GTST---------------PSSEHPLTLQNLDTLNDETERLVDEEENFQK------PDDS 355
G+S S P + + N ETE ++ + + DS
Sbjct: 225 GSSVYFCQGFVNEVMAAGQGSPLPPPDVIQILLQNPETETVMTPDSPSFRGYVANGEGDS 284
Query: 356 ITDEQALTIKDAFLLFRAMAKISAKPLEDSLDMRSHVVRSKLLSLHTLHSILKDHIDVFL 415
T + + +DAFLLF+ + K+S + + +VR K LSL L I+ + V+
Sbjct: 285 ETGDMSKVRQDAFLLFKNLCKLSMRFSSKENNDDQIMVRGKTLSLELLKVIIDNGGSVWR 344
Query: 416 SQNVRVPGKEQVSLVHAVNQYLCLSLARNAASPIAPVYEITLEIMWLIISNLRSEFKREI 475
+ S ++AV QYLCLSL +N+A I ++++ I ++S LRS K EI
Sbjct: 345 TNE---------SFINAVKQYLCLSLLKNSAVSIMSIFQLQCAIFMSLLSKLRSVLKAEI 395
Query: 476 PVFLTDIYFPIADLKSSTNH-QKRYFLSIIQRVCNDPRTLIEFYLNYDCDSHMPNVVELI 534
+F I + + ++ QK L+++ ++ DP+ +++ ++NYDCD N++E I
Sbjct: 396 GIFFPMIVLRVLENVLQPSYLQKMTVLNLLDKMSQDPQLMVDIFVNYDCDVESSNILERI 455
Query: 535 INYLTKLALTRVDVTTSQRAYYNDSLSKPLATFSYTQVXXXXXXXXXXXXXXXXXXFPVD 594
+N L K AL +++ T S Q D
Sbjct: 456 VNGLLKTALGPPTGSST--------------TLSPAQ----------------------D 479
Query: 595 YALKQMALTCMVAFLTSLSSWAHKALNSSSINTVGSSQSKALSQRADSSTLLSSNRPRST 654
+ ++ C+V ++ +W + L + TV S+ + +++ +S +
Sbjct: 480 STFRNDSVKCLVNLAKAMGNWMDQQLKVNE--TVWPKGSQVYASMDSNASQISELEGTIS 537
Query: 655 SALXXXXXXXXXXXXXXXXXXXXXDPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKK 714
++ + L+K + LFN K KG+ I
Sbjct: 538 DCDSQPDTSNPEAYDASMLEQRRAYKIELQVQYLQKG-----ISLFNRKPSKGVEFLIST 592
Query: 715 GFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALR 774
I S +A +L+ T GL+ + +G+YLGE +E + +MHA+VD F F V A+R
Sbjct: 593 KKI-GSSPEEVASFLMKTAGLNGTVIGDYLGERDELPLKVMHAYVDSFNFEKKDFVEAIR 651
Query: 775 LFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIK 834
FL+ FRLPGE QKIDR M KFAE + NP F+ ADTAYVLAYS+I+LNTD H+ +K
Sbjct: 652 FFLRGFRLPGEAQKIDRIMEKFAEHYWKCNPGSFTSADTAYVLAYSVIMLNTDAHNNMVK 711
Query: 835 KKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQ---HQAMISGDATAAL 891
KMT +F+ NN GID+GKDLP EY+ +++ + EI++ S+ ++G L
Sbjct: 712 DKMTKADFVRNNRGIDDGKDLPEEYLGSLYDRVVKEEIRMNSDTLAPQNKQVNG-LNKLL 770
Query: 892 PQQSSFGFFNGKDYEREAYIQVSKQISSKTELVFKNLSKNKDTVYYAASHVEHVKSIFET 951
+ + + + + I E F+ + ++VY+ + + ++ I E
Sbjct: 771 GLDGILNLVSWMQPDEKPHGANGRLIRDIQEQ-FQAKPEKSESVYHTVTDISILRFILEV 829
Query: 952 LWMSFLAALTPPFKEYNDIETSDLCLKGIKTSIKIAATFGIDYARASFVGALIQFANLQN 1011
W LAA + + +D + LCL+G + ++ + A G+ R +FV ++ +F NL
Sbjct: 830 SWGPMLAAFSVTIDQSDDRLATSLCLQGFRYAVHVTAVMGMQTQRDAFVTSMAKFTNLHC 889
Query: 1012 LEEIKIKNVYAIITLLEIAVSEGNYMKDSWKDILVIVSQVERLQLISKGVDRETVPDVTQ 1071
++K KNV A+ ++ IA+ +GN++ SW+ IL +S++E LQL+ + E T+
Sbjct: 890 AADMKQKNVDAVKAIITIAIEDGNHLHGSWEHILTCLSRIEHLQLLGEVSPSEKRYVPTK 949
Query: 1072 ARLANHXXXXXXXXXXXXQNFFDRWTRKATPG----EIAQEKHYNQTLSP-NISKFITSS 1126
+ +F + G + K + ++P I FI +
Sbjct: 950 KAEVDDKKALGFPNLKKRGSFQNPSVMAVVRGGSYDSTSLVKSVPKLVTPEQIKSFIANL 1009
Query: 1127 ELVVLI-----DKIFTNSSALSGSAIVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVD 1181
L+ I + ++ NS L+ AIV F+KAL +VS E+ Q+ T PR+FSL K+V+
Sbjct: 1010 NLLDQIGNFELNHVYANSQRLNSEAIVSFVKALCKVSMSEL---QSPTDPRVFSLTKLVE 1066
Query: 1182 VCYYNMDRIRLEWTPIWNVMGEAFNRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFE 1241
+YNM+RIRL W+ IWNV+ + F + NL+V F +DSLRQLSM+FL+ EEL +
Sbjct: 1067 TAHYNMNRIRLVWSRIWNVLSDFFVSVGLSENLSVAIFVMDSLRQLSMKFLEREELANYH 1126
Query: 1242 FQLDFLKPFEHTVENTRDIDVQEMCIECFHNFILTKSGKIKSGWKPILKSLQYTAQSPNE 1301
FQ +FL+PF ++ + +++E+ + C +L++ +KSGWK + A +
Sbjct: 1127 FQHEFLRPFVVVMQKSSSAEIRELIVRCVSQMVLSRVSNVKSGWKNVFTVFTTAALDERK 1186
Query: 1302 RIVTRTYELVSYDIVKDHFYXXXXXXXXXXXXXXXXKEITKNQKHQ-KLALHSLETL--- 1357
IV +E + IV+DHF+ N K + + +++E L
Sbjct: 1187 NIVLLAFETIE-KIVRDHFHCIIETEITVYADCIRCLITFTNSKFEGDIGFNTIEFLRFC 1245
Query: 1358 -------------KRITNQVADLCFKNHDHQLLQGKDEFEDVWLPLLFCFNDTIMTAVDL 1404
K N ++ L D Q DE W+PLL +
Sbjct: 1246 ALKLEEGGLVLNEKLKNNTISALKEDFSDTQSFTDLDEQVSYWIPLLTGLCKQVSDPRP- 1304
Query: 1405 EVRSRALNYMFDALVANGAEFDEEFWNKICTQLLFPIFGILSKHWEVNQFNSHDDMS--- 1461
+R R++ +F L+ +G F FW I + ++ P+F + ++ S D S
Sbjct: 1305 AIRKRSIEVLFHILMDHGHLFTRPFWTGIFSSIILPVFNNIRSKTDMLFEESVDSPSSAS 1364
Query: 1462 ------VWLSTTLIQALRNMVALFTHYFESLNGLLDGVLGLMVSCICQENDTIARIGRSC 1515
W T AL+ +V L +F S+ L V+ ++V I G S
Sbjct: 1365 LDTEETTWDVETSTLALQLLVDLLVKFFRSVRSQLPSVVSIIVGFIKSPFQGSTGSGISV 1424
Query: 1516 LQQLILQNMSEFNDTHWHQVTEAFSTLFQLTTA 1548
L L ++ W ++ A LT A
Sbjct: 1425 LLHLADGLARSASEDEWREIFLALKEAASLTFA 1457
>CE24576 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1628
Score = 464 bits (1194), Expect = e-130
Identities = 332/1109 (29%), Positives = 544/1109 (48%), Gaps = 166/1109 (14%)
Query: 683 FETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGE 742
FET K +K + +++F+ K KKG+ + GF+ D+ V +A++++ + L+ + VG+
Sbjct: 507 FETLKQQKNLMEQGIQIFSEKPKKGLKFLQEHGFVGTDA-VEVAEFMMKEERLNKTQVGD 565
Query: 743 YLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVD 802
+LG+ +E N S+MHA++D +F+++ I++ALR+FL+KFRLPGE QKIDR MLKFA R++D
Sbjct: 566 FLGDSDEFNNSVMHAYIDFLDFSSIDILAALRMFLEKFRLPGEAQKIDRLMLKFASRYLD 625
Query: 803 QNPN--VFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYM 860
NP +F+ AD AYVLA+SII+L TDLH+ +K KMT + +I N GI+ G ++P E +
Sbjct: 626 CNPRQGIFASADAAYVLAFSIIMLTTDLHNKTVKNKMTKQGYINMNRGINEGGNIPVELL 685
Query: 861 EQIFEEISNHEIK-------------------LLSEQHQAMISGDATAALPQQSSFGFFN 901
E IFE+IS +EIK L +++ + ++ AL + + F F
Sbjct: 686 EAIFEDISKNEIKMRAGATALLRSRVTPGQGALATDKERRAMAALEMEALSETARFRIF- 744
Query: 902 GKDYEREAYIQVSKQISSK--TELVFKNLSK---------NKDTVYYAASHVEHVKSIFE 950
Y R ++ K+ K +++F SK + D + A H HVK +F+
Sbjct: 745 ---YNRRKILKFLKKKFRKFCEKILFFRTSKKLALMESASDADAYFTPAQHQHHVKPMFK 801
Query: 951 TLWMSFLAALTPPFKEYNDIETSDLCLKGIKTSIKIAATFGIDYARASFVGALIQFANL- 1009
W LAA + + +D E LCL+G + ++ A R +F+ AL +F L
Sbjct: 802 ICWTPCLAAFSVGVQMSDDEEEWSLCLRGFRLGVRAACVLQATLERNAFIQALARFTLLT 861
Query: 1010 --QNLEEIKIKNVYAIITLLEIAVSEGNYMKDSWKDILVIVSQVERLQLISKGVDRETVP 1067
+L E+++KN+ AI LL I +G Y++++W D++ +S +E +QLI G++
Sbjct: 862 AKNSLGEMRVKNIEAIKLLLLIGDEDGEYLEENWVDVMKCMSSLELVQLIGTGLNSAMSH 921
Query: 1068 DVTQARLANHXXXXXXXXXXXXQNFFDRWTRKATPGEIAQEKHYNQTLSPNISKFITSSE 1127
D +R ++ KAT G + H Q S S
Sbjct: 922 DTDSSR---------------------QYVMKATGGIDEKTLHSLQDALGETS----SQS 956
Query: 1128 LVVLIDKIFTNSSALSGSAIVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNM 1187
+VV ID+IF S+ LS AIV F++AL VS EE+ + PRMF L K+V+V +YNM
Sbjct: 957 VVVAIDRIFNGSARLSAEAIVYFVRALCAVSREELS---HPAAPRMFLLGKVVEVAFYNM 1013
Query: 1188 DRIRLEWTPIWNVMGEAFNRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFL 1247
+RIRLEW+ IWNV+GE FN SN AV +F++D+LRQLS++FL+ EL F FQ DFL
Sbjct: 1014 NRIRLEWSRIWNVIGEHFNAAGCNSNEAVAYFSVDALRQLSIKFLEKGELPNFRFQKDFL 1073
Query: 1248 KPFEHTVENTRDIDVQEMCIECFHNFILTKSGKIKSGWKPILKSLQYTAQSPNERIVTRT 1307
+PFE + +++ + C + + S ++KSGW+ + A P+ I +
Sbjct: 1074 RPFEVIMVRNGSAQTRDLVVRCCAHLVEAHSSRLKSGWQNLFSVWTIAAGDPSTEIGEAS 1133
Query: 1308 YELVSYDIVKDHFYXXXXXXXXXXXXXXXXKEITKNQKHQKLALHSLETLKRITNQVADL 1367
+ I K +E NQ + + ++ ++ + V++
Sbjct: 1134 FLTAQKVIEKRFKEDFPAFLDSFQEALKCLQEFACNQNQPDMNMEAIRLIRLCADYVSEN 1193
Query: 1368 CFK-----NHDHQLLQGKDEFEDVWL----PLLFCFNDTIMTAVDLEVRSRALNYMFDAL 1418
K D L +G + VWL P+ F + I+ L+VR+R+L MF+ +
Sbjct: 1194 SDKIDEAARRDDHLHKGLTADQHVWLRGWFPIFFELS-CIINRCKLDVRTRSLTVMFEIM 1252
Query: 1419 VANGAEFDEEFWNKICTQLLFPIFGILSKHWEVNQFNSH-DDMSVWLSTTLIQALRNMVA 1477
+G++F E+W K +++F IF + ++ + H D W+STT A+ ++V
Sbjct: 1253 KHHGSDFRPEWW-KDLLEIVFRIF-------DPSKMDDHRSDKREWMSTTCNHAMLSVVE 1304
Query: 1478 LFTHYFESLN-GLLDGVLGLMVSCICQENDTIARIGRSCLQQLILQNMSEFNDTHWHQVT 1536
+FT ++ L+ L + I Q+N+ +AR SCL+ LI QN F + W Q
Sbjct: 1305 VFTQFYTQLSVYALPMIYRQFGIFIRQQNEQLARCTISCLESLISQNGERFTEPMWEQTI 1364
Query: 1537 EAFSTLFQLTTANELFESDPLKQGRRKSVPNTAGTDXXXXXXXXXXXXXXXXXXXXXXXX 1596
E LF+ T L +P PN+ G
Sbjct: 1365 ELIRELFETTLPKSLLTWEP---------PNSNG-------------------------- 1389
Query: 1597 XXXXNGQDVGNEQGTISNGDIDALPPRRLVETKSTEELKQKVSVKNTIVVKCILQLLMIE 1656
+G+E T NG +T S+E+ +V C++Q ++E
Sbjct: 1390 --------IGSEDRT--NGS----------DTLSSEQ-----------IVFCVVQNELVE 1418
Query: 1657 SLSEL-----------FEVEQFINSIPFDEAIKLTTLLERSYEFARDFNDDYELRTRLVE 1705
++S + +++ + + + L S+ A+ FN++ R + +
Sbjct: 1419 AVSRIVLGDHRESKRDLQIDGLFTQMSPQLLLSICDALAESHTLAKQFNNNNGQRVLIWK 1478
Query: 1706 AR-VSNKIPNLAKQETSSSAVLINILFKL 1733
AR + + PNL QET S + ++ ILF+L
Sbjct: 1479 ARLLGSTKPNLINQETRSLSAMLAILFRL 1507
Score = 172 bits (436), Expect = 5e-42
Identities = 139/497 (27%), Positives = 239/497 (47%), Gaps = 86/497 (17%)
Query: 82 MNNANIKSVV-LFVKSTLESIMKSKELKKLTS------CQKDIERTLKSLEQTSAAPT-- 132
++N KS+ +F++S +E I+ +++K+ + C+ +E LK+ E+ A+P+
Sbjct: 4 LSNGPKKSIGNMFLRSGIEKILADRDIKRKENLQLKKACESALEE-LKAAEEQDASPSSN 62
Query: 133 --------GTSVEIDSLLVFEALRSCCRSKIIDIQIKALDCFAKLFSFQALDESLLVNPP 184
GT+VE D F C SK I I ALDC KL ++ L
Sbjct: 63 GEHLPDAGGTAVEADRY--FLPFELACNSKSPKIVITALDCLQKLIAYGHLT-------- 112
Query: 185 DSMASNDQNPENIGITPPPKQKLIDAVIDTICDCFEGENTDSRVELQVVRGLASCILIDE 244
++ NPE +KLID +++ IC F G+ TD V LQ+++ + + +L
Sbjct: 113 -GRGADISNPE---------RKLIDRIVEAICAPFLGQGTDETVLLQLIKAVLAVVL--- 159
Query: 245 ATSC-VHGASLLKAIRQIYNIFIFSLHSSNQGIAQATLTQIVTTVFDRID---------- 293
+T C VHGASL+ A+R +NI++ S NQ A+ TLTQ++ TVF ++
Sbjct: 160 STHCEVHGASLILAVRTCFNIYLTSKSPINQATAKGTLTQVINTVFGNMEKFGNIKDDET 219
Query: 294 -VKSLNQQRSLSTIS--LKNAASTNGGTSTPSSEHPLTLQNLDTLNDETERLVDEEENFQ 350
V+ + + +TIS + + S GGT QN T+ E+E +D++ F
Sbjct: 220 IVREVVEVLVSNTISNEVSDETSEAGGTHR---------QNGSTMG-ESEAPLDDQFTFM 269
Query: 351 KPDDSITDEQALTIKDAFLLFRAMAKISAKPLEDSLDMRSHVVRSKLLSLHTLHSILKDH 410
KDAFL+FRA+ ++ K E+ +RSKLL+L L +L++
Sbjct: 270 NAYQ----------KDAFLVFRALCILAQK--EEGGASNEMSLRSKLLALEMLLLVLQNS 317
Query: 411 IDVFLSQNVRVPGKEQVSLVHAVNQYLCLSLARNAASPIAPVYEITLEIMWLIISNLRSE 470
+ S + + + LC++L RNA S V+E +L I ++ ++
Sbjct: 318 SSILQSSQ---------PCIIVIKRTLCMALTRNAVSNNIQVFEKSLAIFVELLDKFKTH 368
Query: 471 FKREIPVFLTDIYFPIADLKSSTNHQKRYFLSIIQRVCNDPRTLIEFYLNYDCDSHMPNV 530
K I VF + P+ D + QK L+ I ++ +P+++++ ++NYDCD PN+
Sbjct: 369 LKASIEVFFNSVILPMLDSNTCAFEQKWIVLNTIGKILANPQSVVDMFVNYDCDMTSPNL 428
Query: 531 VELIINYLTKLALTRVD 547
+ I+ ++K T ++
Sbjct: 429 FKSIVEVVSKTTRTTIN 445
>At3g43300 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1669
Score = 287 bits (735), Expect = 1e-76
Identities = 234/888 (26%), Positives = 397/888 (44%), Gaps = 134/888 (15%)
Query: 680 PLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSA 739
P FE AK K+ + + FN + KG+ I +E + + ++A++L +T L
Sbjct: 559 PSNFEKAKAHKSTMEAAISEFNRNSVKGVEYLIANKLVERNPA-SVAQFLRSTSSLSKVM 617
Query: 740 VGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAER 799
+G+YLG+ E +++MHA+VD +F+ + SA+R FL+
Sbjct: 618 IGDYLGQHEEFPLAVMHAYVDSMKFSEMKFHSAIREFLK--------------------- 656
Query: 800 FVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREY 859
NP +F ADTAYVLAY++I+LNTD H+ + KM+ +F N+ D P E
Sbjct: 657 ---DNPGLFKNADTAYVLAYAVIMLNTDAHNPMVWPKMSKSDFTRMNATNDPEDCAPTEL 713
Query: 860 MEQIFEEISNHEIKLLSEQHQAMIS-----GDATAALPQQSSFGF---FNGKDYEREAYI 911
+E+I++ I EIKL + +S G+ L + G + D + E
Sbjct: 714 LEEIYDSIVQEEIKLKDDDTMKKLSSQRPGGEERGGLVSILNLGLPKRISAADAKSE--- 770
Query: 912 QVSKQISSKTELVFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIE 971
++ I KT+ +F+ K V++ V+ ++ + E + LAA + + ++
Sbjct: 771 --TEDIVRKTQEIFRKHGV-KRGVFHTVEQVDIIRPMVEAVGWPLLAAFSVTMEVGDNKP 827
Query: 972 TSDLCLKGIKTSIKIAATFGIDYARASFVGALIQFANLQNLEEIKIKNVYAIITLLEIAV 1031
LC++G K I IA G+D R +F+ +L++F L +E++ KNV A+ LL +
Sbjct: 828 RILLCMEGFKAGIHIAYVLGMDTMRYAFLTSLVRFTFLHAPKEMRSKNVEALRILLGLCD 887
Query: 1032 SEGNYMKDSWKDILVIVSQVERLQLISKGVDRETVPDVTQARLANHXXXXXXXXXXXXQN 1091
SE + ++D+W +L VS++E +
Sbjct: 888 SEPDTLQDTWNAVLECVSRLEFI------------------------------------- 910
Query: 1092 FFDRWTRKATPGEIAQEKHYNQTLSPNISKFITSSELVVLIDKIFTNSSALSGSAIVDFI 1151
+TPG A H + +S + +++F NS L ++V+F
Sbjct: 911 -------ISTPGIAATVMHGSNQISRDGVVQSLKELAGRPAEQVFVNSVKLPSESVVEFF 963
Query: 1152 KALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNMDRIRLEWTPIWNVMGEAFNRIATE 1211
AL VS EE++ S R+FSLQK+V++ YYN+ RIR+ W IW+V+ E F +
Sbjct: 964 TALCGVSAEELKQS----PARVFSLQKLVEISYYNIARIRMVWARIWSVLAEHFVSAGSH 1019
Query: 1212 SNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPFEHTVENTRDIDVQEMCIECFH 1271
+ + +AIDSLRQL M++L+ ELT F FQ D LKPF + NT
Sbjct: 1020 HDEKIAMYAIDSLRQLGMKYLERAELTNFTFQNDILKPFVIIMRNT-------------- 1065
Query: 1272 NFILTKSGKIKSGWKPILKSLQYTAQSPNERIVTRTYELVSYDIVKDHFYXXXXXXXXXX 1331
Q A E IV +++E V ++ +HF
Sbjct: 1066 ---------------------QTAADDEVESIVEKSFENVE-QVILEHF--DQVIGDCFM 1101
Query: 1332 XXXXXXKEITKNQKHQKLALHSLETLKRITNQVADLCFKNHDHQLLQG-KDEFEDV---- 1386
N+ +++L ++ L+ +++A+ + + G +DE DV
Sbjct: 1102 DCVNCLIRFANNKASDRISLKAIALLRICEDRLAEGLIPGGVLKPVDGNEDETFDVTEHY 1161
Query: 1387 WLPLLFCFNDTIMTAVDLEVRSRALNYMFDALVANGAEFDEEFWNKICTQLLFPIFGILS 1446
W P+L +D + + EVR+ AL +FD L G +F FW I ++LFPIF +S
Sbjct: 1162 WFPMLAGLSD-LTSDYRPEVRNCALEVLFDLLNERGNKFSTPFWESIFHRILFPIFDHVS 1220
Query: 1447 KHWEVNQFNSHDDMSVWLSTTLIQALRNMVALFTHYFESLNGLLDGVLGLMVSCICQEND 1506
+ + +S D V T I +L+ + LF +++ + +L +L L++ C + +
Sbjct: 1221 HAGKESLISSGD---VKFRETSIHSLQLLCNLFNTFYKEVCFMLPPLLSLLLDCAKKSDQ 1277
Query: 1507 TIARIGRSCLQQLILQNMSEFNDTHWHQVTEAFSTLFQLTTANELFES 1554
T+ I L LI +F++ W + ++ T EL +
Sbjct: 1278 TVVSISLGALVHLIEVGGHQFSEGDWDMLLKSIRDASYTTQPLELLNA 1325
Score = 112 bits (281), Expect = 4e-24
Identities = 127/490 (25%), Positives = 211/490 (42%), Gaps = 95/490 (19%)
Query: 102 MKSKELKKLTSC-------QKDIERTLKSLEQTSAAPTGTSVEIDSLLVFEALRSCCRSK 154
+++ E +K+TS Q E SL G VE LV + LR +K
Sbjct: 63 VEADEPQKVTSAEVAQQASQSKSETINVSLANAGHTLGGAEVE----LVLKPLRLAFETK 118
Query: 155 IIDIQIKALDCFAKLFSFQALDESLLVNPPDSMASNDQNPENIGITPPPKQKLIDAVIDT 214
+ I ALDC KL ++ L+ P + P +++
Sbjct: 119 NLKIFDAALDCLHKLIAYDHLE-----GDPGLDGGKNSAP-------------FTDILNM 160
Query: 215 ICDCFEGENTDSRVELQVVRGLASCILIDEATSCVHGASLLKAIRQIYNIFIFSLHSSNQ 274
+C C + + DS V LQV++ L + + + VHG LL IR YNI + S NQ
Sbjct: 161 VCSCVDNSSPDSTV-LQVLKVLLTAVASGKFK--VHGEPLLGVIRVCYNIALNS--PINQ 215
Query: 275 GIAQATLTQIVTTVFDRIDVKSLNQQRSLSTISLKNAASTNGGTSTPSSEH--------- 325
++A LTQ+++ VF R++ ++ ST+S + S G TS+P +E
Sbjct: 216 ATSKAMLTQMISIVFRRMETDIVSAS---STVSQEEHVS--GDTSSPKNEEITAADENEK 270
Query: 326 PLTLQNLDTLNDETERLVDEE-----------------------ENFQKPDDSIT-DEQA 361
+TL + T +T EE E+ +K I + +
Sbjct: 271 EMTLGDALTQAKDTTLASVEELHTLVGGADIKGLEAALDKAVHLEDGKKIKRGIELESMS 330
Query: 362 LTIKDAFLLFRAMAKISAKPLEDSLDMRSHVVRSKLLSLHTLHSILKDHIDVFLSQNVRV 421
+ +DA L+FR + K+ K EDS ++ + ++++LSL L +L+ F
Sbjct: 331 IGQRDALLVFRTLCKMGMK--EDSDEVTT---KTRILSLELLQGMLEGVSHSFT------ 379
Query: 422 PGKEQVSLVHAVNQYLCLSLARNAASPIAPVYEITLEIMWLIISNLRSEFKREIPVFLTD 481
+ + +V YL +L R + S + +++ I +++ R K EI +F
Sbjct: 380 ---KNFHFIDSVKAYLSYALLRASVSQSSVIFQYASGIFSVLLLRFRDSLKGEIGIFFPI 436
Query: 482 IYFPIADLKSSTNHQK----RY--FLSI---IQRVCNDPRTLIEFYLNYDCDSHMPNVVE 532
I D N QK RY FL + +++VC DP+ L++ Y+NYDCD PN+ E
Sbjct: 437 IVLRSLDNSECPNDQKMGVLRYNIFLLVQMMLEKVCKDPQMLVDVYVNYDCDLEAPNLFE 496
Query: 533 LIINYLTKLA 542
++ L+K+A
Sbjct: 497 RMVTTLSKIA 506
>At1g13980 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1451
Score = 185 bits (470), Expect = 5e-46
Identities = 164/636 (25%), Positives = 277/636 (42%), Gaps = 59/636 (9%)
Query: 687 KLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDD-SSVAIAKWLLNTDGLDLSAVGEYLG 745
K K L+ FN KKG+ + D ++A + T GLD + VG++LG
Sbjct: 559 KYIKRRLMIGADHFNRDPKKGLEFLQGTHLLPDKLDPQSVACFFRYTAGLDKNLVGDFLG 618
Query: 746 EGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNP 805
+E + +++ F F+F +++ +ALRLFL+ FRLPGE QKI R + F+ER+ Q+P
Sbjct: 619 NHDEFCVQVLNEFAGTFDFQYMNLDTALRLFLETFRLPGESQKIQRVLEAFSERYYMQSP 678
Query: 806 NVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFE 865
+ + D A VL+YSII+LNTD H+ Q+KKKMT E+FI NN I+ G DLPRE++ ++F
Sbjct: 679 EILANKDAALVLSYSIIMLNTDQHNVQVKKKMTEEDFIRNNRHINGGNDLPREFLSELFH 738
Query: 866 EISNHEIKLLSEQHQAMISGDATAALPQQSSFGFFNGKDYEREAYIQVSKQISSKTELVF 925
I N+EI+ EQ A P+ + S +L+
Sbjct: 739 SICNNEIRTTPEQ---------GAGFPEMTP---------------------SRWIDLMH 768
Query: 926 KNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIETSDLCLKGIKTSIK 985
K+ + + ++++H +F + +AA++ F + C+ G K
Sbjct: 769 KSKKTAPYILADSRAYLDH--DMFAIMSGPTIAAISVVFDHAEHEDVYQTCIDGFLAIAK 826
Query: 986 IAATFGIDYARASFVGALIQFANLQNLEEI---------KIKNVYAIITLLEIAVSEGNY 1036
I+A ++ V +L +F L N + K A IT+ IA G+Y
Sbjct: 827 ISACHHLEDVLDDLVVSLCKFTTLLNPSSVDEPVLAFGDDAKARMATITIFTIANKYGDY 886
Query: 1037 MKDSWKDILVIVSQVERLQLISKGVDRETVPDVTQAR-------LANHXXXXXXXXXXXX 1089
++ W++IL + ++ +L L+ V + + + LAN
Sbjct: 887 IRTGWRNILDCILRLHKLGLLPARVASDAADESEHSSEQGQGKPLANSLSSAHLQSMGTP 946
Query: 1090 QNFFDRWTRKATPGEIAQEKHYNQTLSPNISKFITSSELV--VLIDKIFTNSSALSGSAI 1147
+ R + + E+ +Q ++ + + + ID IFT S L ++
Sbjct: 947 RRSSGLMGRFSQLLSLDTEEPRSQPTEQQLAAHQRTLQTIQKCHIDSIFTESKFLQAESL 1006
Query: 1148 VDFIKALTEVSF--EEIESSQNATTPRMFSLQKMVDVCYYNMDRIRLEWTPIWNVMGEAF 1205
+ +AL + ++ SS +F L+ ++ + N DRI L W ++ +
Sbjct: 1007 LQLARALIWAAGRPQKGTSSPEDEDTAVFCLELLIAITLNNRDRIVLLWQGVYEHIATIA 1066
Query: 1206 NRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPFEHTVENTRDIDVQEM 1265
NL V AI L ++ R L +E E L L+ D +++
Sbjct: 1067 QSTVMPCNL--VDKAIFGLLRICQRLLPYKESLADEL-LRSLQLVLKLDARVADAYCEQI 1123
Query: 1266 CIECFHNFILTKSGKIKS--GWKPILKSLQYTAQSP 1299
IE + + I+S GW+ I L TA+ P
Sbjct: 1124 AIE-VSRLVKANANHIRSQAGWRTITSLLSITARHP 1158
>At5g19610 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1375
Score = 170 bits (430), Expect = 2e-41
Identities = 151/657 (22%), Positives = 297/657 (44%), Gaps = 75/657 (11%)
Query: 687 KLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDD--SSVAIAKWLLNTDGLDLSAVGEYL 744
K +K +L FN KKG+ E +K ++ D +A+A + T GLD + +G+YL
Sbjct: 491 KAQKRKLAIAANHFNRDEKKGL-EYLKYNYLVSDPLDPMALASFFRFTPGLDKTMIGDYL 549
Query: 745 GEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVD-Q 803
G+ +E ++S++ +F FEFT +++ +ALR FL+ FRLPGE QKI+R + F+ERF D Q
Sbjct: 550 GDPDELHLSVLRSFTHTFEFTGMNLDTALRTFLESFRLPGESQKIERMIEAFSERFYDQQ 609
Query: 804 NPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQI 863
+ ++F+ DT ++L YS+I+LNTD H+ Q+++KMT +EFI NN I+ G DLP+EY+ ++
Sbjct: 610 SSDIFASKDTVHILCYSLIMLNTDQHNPQVRRKMTEDEFIRNNRAINAGNDLPKEYLSEL 669
Query: 864 FEEISNHEIKLLSEQHQAMISGDATAALPQQSSFGFFNGKDYEREAYIQVSKQISSKTEL 923
F+ I+ + L + ++ + L ++ K + + Q ++I
Sbjct: 670 FQSIATNAFALSTHSGPVEMNPNRWIELMNRT-------KTTQPFSLCQFDRRIG----- 717
Query: 924 VFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIETSDLCLKGIKTS 983
+ +F T+ +AA++ F+ +D E C+ + S
Sbjct: 718 ----------------------RDMFATIAGPSIAAVSAFFEHSDDDEVLHECVDAM-IS 754
Query: 984 IKIAATFGIDYARASFVGALIQFANLQNLEEIKIKNVYAI----------ITLLEIAVSE 1033
I A +G++ + + +F L N + ++A + + +A +
Sbjct: 755 IARVAQYGLEDILDELIASFCKFTTLLNPYTTPEETLFAFSHDMKPRMATLAVFTLANTF 814
Query: 1034 GNYMKDSWKDILVIVSQVERLQLISKGVDRETVPDVTQARLANHXXXXXXXXXXXXQNFF 1093
G+ ++ W++I+ + ++ +LQL+ + V + + N F
Sbjct: 815 GDSIRGGWRNIVDCLLKLRKLQLLPQSVIEFEINE------ENGGSESDMNNVSSQDTKF 868
Query: 1094 DRWTRKATPGEIAQ---EKHYNQTLSPNISKFITSSELV--VLIDKIFTNSSALSGSAIV 1148
+R + G + + ++++ +S+F + +++ I +IF+ SS L A++
Sbjct: 869 NRRQGSSLMGRFSHFLALDNVEESVALGMSEFEQNLKVIKQCRIGQIFSKSSVLPDVAVL 928
Query: 1149 DFIKALTEVSFEEIESSQNATTPR---MFSLQKMVDVCYYNMDRIRLEWTPIWNVMGEAF 1205
+ ++L + + + A F ++ + N+ R + W +
Sbjct: 929 NLGRSLIYAAAGKGQKFSTAIEEEETVKFCWDLIITIALSNVHRFNMFWPSYHEYLLNVA 988
Query: 1206 NRIATESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPFEHTVENTRDIDVQEM 1265
N S + V + L ++ ++ L +L F T+ D ++ E
Sbjct: 989 N-FPLFSPIPFVEKGLPGLFRVCIKILASNLQDHLPEELIFR---SLTIMWKIDKEIIET 1044
Query: 1266 CIECFHNF----ILTKSGKIKS--GWKPILKSLQYTAQSP--NERIVTRTYELVSYD 1314
C + F I+ S + + GWK +L+ L + P E+ V L+S++
Sbjct: 1045 CYDTITEFVSKIIIDYSANLHTNIGWKSVLQLLSLCGRHPETKEQAVDALIGLMSFN 1101
>At5g39500 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1443
Score = 165 bits (418), Expect = 6e-40
Identities = 154/609 (25%), Positives = 271/609 (44%), Gaps = 89/609 (14%)
Query: 724 AIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLP 783
++A + T GLD + +G++LG ++ I ++H F F+F N+++ +ALRLF+ F+L
Sbjct: 597 SVACFFRYTCGLDKNVMGDFLGNHDQFCIQVLHEFAKTFDFQNMNLATALRLFVGTFKLS 656
Query: 784 GEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFI 843
GE QKI R + F+ER+ +Q+P++ D A+VLAYSIILLNTD H+ Q+K +MT E+FI
Sbjct: 657 GEAQKIHRVLEAFSERYYEQSPHILIDKDAAFVLAYSIILLNTDQHNAQVKTRMTEEDFI 716
Query: 844 ENNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQHQAMISGDATAALPQQSSFGFFNGK 903
NN I+ G DLPREY+ +I+ I + EI+ + + GF
Sbjct: 717 RNNRTINGGADLPREYLSEIYHSIRHSEIQ-----------------MDEDKGTGF---- 755
Query: 904 DYEREAYIQVSKQISSKTELVFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPP 963
+ S+ IS +++K+ + AASH++ + +F + +AA +
Sbjct: 756 -----QLMTASRWIS----VIYKSKETSPYIQCDAASHLD--RDMFYIVSGPTIAATSVV 804
Query: 964 FKEYNDIETSDLCLKGIKTSIKIAATFGIDYARASFVGALIQ----FANLQNLEEIKI-- 1017
F++ + C+ G+ K++A + ++ V +L + FA L E + +
Sbjct: 805 FEQAEQEDVLRRCIDGLLAIAKLSAYYHLNSVLDDLVVSLCKFTPFFAPLSADEAVLVLG 864
Query: 1018 ---KNVYAIITLLEIAVSEGNYMKDSWKDILVIVSQVERLQLISKGV--DRETVPDVTQA 1072
+ A + IA G+Y+ WK+IL V + +L ++ + D P+++ +
Sbjct: 865 EDARARMATEAVFLIANKYGDYISAGWKNILECVLSLNKLHILPDHIASDAADDPELSTS 924
Query: 1073 RLANH----------XXXXXXXXXXXXQNF-------FDRWTRKATPG--EIAQEKHYNQ 1113
L +F FD K P E+A KH
Sbjct: 925 NLEQEKPSANPVPVVSQSQPSAMPRKSSSFIGRFLLSFDSEETKPLPSEEELAAYKHARG 984
Query: 1114 TLSPNISKFITSSELVVLIDKIFTNSSALSGSAIVDFIKALTEVSFEEIESSQNATTPRM 1173
+ ID IF++S L ++ + +L S ++ SS +
Sbjct: 985 IVKD------------CHIDSIFSDSKFLQAESLQQLVNSLIRASGKDEASS-------V 1025
Query: 1174 FSLQKMVDVCYYNMDRIRLEWTPIW-NVMGEAFNRIATESNLAVVFFAIDSLRQLSMRFL 1232
F L+ ++ V N DRI L W ++ +++G T + +V A+ + ++ R L
Sbjct: 1026 FCLELLIAVTLNNRDRILLIWPTVYEHILGIV---QLTLTPCTLVEKAVFGVLKICQRLL 1082
Query: 1233 DIEELTGFEFQLDFLKPFEHTVENTRDIDVQEMCIECFHNFILTKSGKIKS--GWKPILK 1290
+E E L L+ D + + E + + ++S GW+ I+
Sbjct: 1083 PYKENLTDEL-LKSLQLVLKLKAKVADAYCERIAQEVV-RLVKANASHVRSRTGWRTIIS 1140
Query: 1291 SLQYTAQSP 1299
L TA+ P
Sbjct: 1141 LLSITARHP 1149
>Hs8670544 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 397
Score = 165 bits (417), Expect = 7e-40
Identities = 84/177 (47%), Positives = 117/177 (65%), Gaps = 1/177 (0%)
Query: 698 KLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHA 757
K FN KKGI I+ +++ IA++L +GL+ +A+G+YLGE +E NI ++HA
Sbjct: 71 KKFNMDPKKGIQFLIENDLLKNTCE-DIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHA 129
Query: 758 FVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVL 817
FV+ EFT+L++V ALR FL FRLPGE QKIDR M FA+R+ N VF DT YVL
Sbjct: 130 FVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVL 189
Query: 818 AYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKL 874
+++II+LNT LH+ +K K T+E FI N GI++G DLP E + ++E I N K+
Sbjct: 190 SFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKI 246
>Hs4758964 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 398
Score = 165 bits (417), Expect = 7e-40
Identities = 84/177 (47%), Positives = 117/177 (65%), Gaps = 1/177 (0%)
Query: 698 KLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHA 757
K FN KKGI I+ +++ IA++L +GL+ +A+G+YLGE +E NI ++HA
Sbjct: 71 KKFNMDPKKGIQFLIENDLLKNTCE-DIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHA 129
Query: 758 FVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVL 817
FV+ EFT+L++V ALR FL FRLPGE QKIDR M FA+R+ N VF DT YVL
Sbjct: 130 FVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQSTDTCYVL 189
Query: 818 AYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKL 874
+++II+LNT LH+ +K K T+E FI N GI++G DLP E + ++E I N K+
Sbjct: 190 SFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKI 246
>Hs8670546 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 400
Score = 163 bits (412), Expect = 3e-39
Identities = 80/177 (45%), Positives = 116/177 (65%), Gaps = 1/177 (0%)
Query: 698 KLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHA 757
K FN KKGI ++ +++ IA++L +GL+ +A+G+YLGE E N++++HA
Sbjct: 70 KKFNMDPKKGIQFLVENELLQNTPE-EIARFLYKGEGLNKTAIGDYLGEREELNLAVLHA 128
Query: 758 FVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVL 817
FVD EFT+L++V ALR FL FRLPGE QKIDR M FA+R+ NP VF DT YVL
Sbjct: 129 FVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVL 188
Query: 818 AYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKL 874
++++I+LNT LH+ ++ K LE F+ N GI+ G DLP E + +++ I N K+
Sbjct: 189 SFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKI 245
>Hs4758966 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 399
Score = 163 bits (412), Expect = 3e-39
Identities = 80/177 (45%), Positives = 116/177 (65%), Gaps = 1/177 (0%)
Query: 698 KLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHA 757
K FN KKGI ++ +++ IA++L +GL+ +A+G+YLGE E N++++HA
Sbjct: 70 KKFNMDPKKGIQFLVENELLQNTPE-EIARFLYKGEGLNKTAIGDYLGEREELNLAVLHA 128
Query: 758 FVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVL 817
FVD EFT+L++V ALR FL FRLPGE QKIDR M FA+R+ NP VF DT YVL
Sbjct: 129 FVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVL 188
Query: 818 AYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKL 874
++++I+LNT LH+ ++ K LE F+ N GI+ G DLP E + +++ I N K+
Sbjct: 189 SFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKI 245
>7302131 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 348
Score = 162 bits (410), Expect = 5e-39
Identities = 81/177 (45%), Positives = 115/177 (64%), Gaps = 1/177 (0%)
Query: 698 KLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHA 757
K FN KKGI ++ + D +A +L +GL+ +A+G+YLGE N+ N ++ A
Sbjct: 24 KKFNMDPKKGIEYLVENRLLRHDPQ-DVAHFLYKGEGLNKTAIGDYLGEKNDFNEDVLKA 82
Query: 758 FVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVL 817
FV +FTNL +V ALR FL FRLPGE QKIDR M FA+R+ NP++F+ DT YVL
Sbjct: 83 FVALHDFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRYCQLNPDIFTNTDTCYVL 142
Query: 818 AYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKL 874
+++II+LNT LH+ +K K T+++FI N GI+NG DLPR +E ++E I K+
Sbjct: 143 SFAIIMLNTSLHNPSVKDKPTVDQFISMNRGINNGGDLPRGLLESLYESIRTEPFKI 199
>Hs4758416 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1859
Score = 161 bits (407), Expect = 1e-38
Identities = 141/576 (24%), Positives = 256/576 (43%), Gaps = 63/576 (10%)
Query: 679 DPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDD-SSVAIAKWLLNTDGLDL 737
DP + K +K L+ + FN K KKGI +KG + + +A+WL LD
Sbjct: 689 DPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDK 748
Query: 738 SAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFA 797
+GE++ + KNI ++ +FV F F L + ALRL+L+ FRLPGE I R + F
Sbjct: 749 KMIGEFVSD--RKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFT 806
Query: 798 ERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKK---MTLEEFIENNSGIDNGKD 854
ER+++ N + F+ +D + LAY++I+LNTD H+ ++K+ MTLEEF +N G++ GKD
Sbjct: 807 ERWMNCNGSPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKD 866
Query: 855 LPREYMEQIFEEISNHEIKLLSEQHQAMISGDATAALPQQSSFGFFNGKDYEREAYIQVS 914
++ +E ++ I N EI + EQ + RE Y+
Sbjct: 867 FEQDILEDMYHAIKNEEIVMPEEQTGLV------------------------RENYVW-- 900
Query: 915 KQISSKTELVFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIETSD 974
V + + ++ + +F W +AAL+ F + +
Sbjct: 901 --------NVLLHRGATPEGIFLRVPTASYDLDLFTMTWGPTIAALSYVFDKSLEETIIQ 952
Query: 975 LCLKGIKTSIKIAATFGIDYARASFVGALIQFA-----NLQNLEEIKIKNVYAII---TL 1026
+ G + I+A +G+ + + +L +F +++NL + N A I T+
Sbjct: 953 KAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTV 1012
Query: 1027 LEIAVSEGNYMKDSWKDILVIVSQVERLQLISKG-VDRETVPDVTQARLANHXXXXXXXX 1085
+A G+ +++ WK+I+ + Q+ R QL+ K ++ E D +++
Sbjct: 1013 FHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEVEDFVD-PNGKISLQREETPSNR 1071
Query: 1086 XXXXQNFFDRWTRKATPGEIAQEKHYNQTLSPNISKFITSSELVVLID--KIFTNSSALS 1143
F W + P ++ + N + E + D K+ T S L
Sbjct: 1072 GESTVLSFVSWLTLSGP----EQSSVRGPSTENQEAKRVALECIKQCDPEKMITESKFLQ 1127
Query: 1144 GSAIVDFIKALTEVS-FEEIESSQNATTPRMFSLQKMVDVCYYNMDRIRLEWTPIWNVMG 1202
++ + +KAL V+ EE ++A F L+ ++ + N DR+ W + + +
Sbjct: 1128 LESLQELMKALVSVTPDEETYDEEDAA----FCLEMLLRIVLENRDRVGCVWQTVRDHLY 1183
Query: 1203 EAFNRIATESNLAVVFFAIDSLRQLSMRFLDIEELT 1238
+ + +V A+ L +L++R L EE++
Sbjct: 1184 HLC--VQAQDFCFLVERAVVGLLRLAIRLLRREEIS 1217
>Hs4758968 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 399
Score = 157 bits (398), Expect = 1e-37
Identities = 81/177 (45%), Positives = 112/177 (62%), Gaps = 1/177 (0%)
Query: 698 KLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHA 757
K FN KKGI I+ ++ S +A++L +GL+ + +G+YLGE +E NI ++ A
Sbjct: 75 KKFNMDPKKGIQFLIENDLLQS-SPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQA 133
Query: 758 FVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVL 817
FV+ EF +L++V ALR FL FRLPGE QKIDR M FA R+ NP VF DT YVL
Sbjct: 134 FVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVL 193
Query: 818 AYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKL 874
+++II+LNT LH+ ++ K T E FI N GI+ G DLP E + ++E I N K+
Sbjct: 194 SFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKI 250
>Hs7019505 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 394
Score = 153 bits (387), Expect = 2e-36
Identities = 81/193 (41%), Positives = 116/193 (59%), Gaps = 3/193 (1%)
Query: 684 ETAKLRKTELLNCV--KLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVG 741
E +++ + E C+ K FN KGI I+ + D IA++L +GL+ +A+G
Sbjct: 54 EESRMAQKEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQ-DIARFLYKGEGLNKTAIG 112
Query: 742 EYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFV 801
YLGE + N+ ++ AFVD EF NL++V ALR FL FRLPGE QKIDR M FA R+
Sbjct: 113 TYLGERDPINLQVLQAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYC 172
Query: 802 DQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYME 861
NP VF DT YVL++SII+LNT LH+ ++ + E F+ N GI+NG DLP + +
Sbjct: 173 LCNPGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLR 232
Query: 862 QIFEEISNHEIKL 874
+F+ I + +
Sbjct: 233 NLFDSIKSEPFSI 245
>SPBC211.03c [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1462
Score = 145 bits (366), Expect = 6e-34
Identities = 109/360 (30%), Positives = 176/360 (48%), Gaps = 50/360 (13%)
Query: 686 AKLRKTELLNCVKLFNYKTKKGIAESIKKGFI-EDDSSVAIAKWLLNTDGLDLSAVGEYL 744
+K RK ++ +LFN GIA + I + D+ I ++ +T+ L +GE+L
Sbjct: 545 SKKRKAIIIEGAELFNESPSDGIAFLTQHSIIKQSDNPTCIVEFFHSTNRLSKRVLGEFL 604
Query: 745 GEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQN 804
+G+ N I++AF+ F+F I ALRL LQ FRLPGE Q I+R + F+ ++ N
Sbjct: 605 TKGS--NSHILNAFISAFDFKGKRIDEALRLLLQSFRLPGESQLIERVLETFSHYYMSAN 662
Query: 805 PNVFSKADTAYVLAYSIILLNTDLHSTQIK--KKMTLEEFIENNSGIDNGKDLPREYMEQ 862
P+ S D A+VL+YSII+LNTD H+ IK ++MTL++F N G+++G+D R ++ +
Sbjct: 663 PDSMSSKDAAFVLSYSIIMLNTDQHNPNIKSQRRMTLDDFCRNVRGVNDGQDFDRNFLSE 722
Query: 863 IFEEISNHEIKLLSEQHQAMISGDATAALPQQSSFGFFNGKDYEREAYIQVSKQISSKTE 922
I++ I +EI +++E+H +S YI Q S K
Sbjct: 723 IYKAIKENEI-IVAEEHDTELS-----------------------FLYIWSKLQQSVKIT 758
Query: 923 LVFKNLSKNKDTVYYAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIETSDLCLKGIKT 982
FK S N H K +F +W S +AAL F + + GI+
Sbjct: 759 EPFKRSSSN-----------VHDKIVFLEVWKSIMAALIYVFSTATEDTVFYRVVNGIQQ 807
Query: 983 SIKIAATFGIDYARASFVGALIQFANL--------QNLEEIKIKNVYAIITLLEIAVSEG 1034
+ ++AA + ++ + QF L Q IK+++ IIT+ E++V G
Sbjct: 808 ATEVAAAYELNEPVDYAIERFCQFTALDPSSVPGTQLNTAIKVED--RIITVSELSVRFG 865
>CE19701 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1820
Score = 142 bits (357), Expect = 7e-33
Identities = 184/831 (22%), Positives = 312/831 (37%), Gaps = 157/831 (18%)
Query: 429 LVHAVNQYLCLSLARNAASPIAPVYEITLEIMWLIISNLRSEFKREIPVFLTDIY-FPIA 487
L+ + LC +L + + PV T +L+ ++R K ++ +L + +
Sbjct: 436 LMPLIKNELCRNLLQLLDTNRLPVLAATNRCCFLLFESMRMHMKFQLESYLKKLQSIVLT 495
Query: 488 DLKSSTN-----HQKRYFLSIIQRVCNDPRTLIEFYLNYDCDSHMPNVVELIINYLTKLA 542
+ K N QK L + ++ P + E YLN+DCD + N+ E + L + +
Sbjct: 496 EEKQHENGGGGTEQKEMALESLVQLWRIPGLVTEMYLNFDCDLYCGNIFEDLTKLLVENS 555
Query: 543 LTRVDVTTSQRAYYNDSLSKPLATFSYTQVXXXXXXXXXXXXXXXXXXFPVDYALKQMAL 602
V T+ D+L + T LK++ L
Sbjct: 556 FPTVGGHTASLLSL-DALLVVIETIEQNCEDRENGRGEVAKEQEHKD-------LKKLGL 607
Query: 603 TCMVAFLTSLSSWAHKALNSSSINTVGSSQSKALSQRADSSTLLSSNRPRSTSALXXXXX 662
+ + +I+T G KA SS +L SNR ++ L
Sbjct: 608 PVLSGY---------DLAKKMAISTGG----KASPMPVSSSIVLRSNRHAPSTELPSMS- 653
Query: 663 XXXXXXXXXXXXXXXXDPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSS 722
Q K RK + +LFN KKGIA +KG + D
Sbjct: 654 -------------------QIIEQKKRKRLIAEGTELFNQSPKKGIAFLREKGILGHDEQ 694
Query: 723 VAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRL 782
++ +WL LD A+ +Y+ N K+ +++AFV F F N + ALR+FL+ FRL
Sbjct: 695 -SLVQWLRTNPQLDKKAIADYIC--NRKHAEVLNAFVKSFPFENTRLDVALRMFLETFRL 751
Query: 783 PGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKK---MTL 839
PGE +I M F+E + N F D A+ L+Y+II+LN D H+ Q K+ MT+
Sbjct: 752 PGESAEIALVMQHFSEEWFRANNEPFFHVDAAFTLSYAIIMLNVDQHNPQAKRSQPPMTV 811
Query: 840 EEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQHQAMISGDATAALPQQSSFGF 899
+ F N SG ++ +D E + +++ I EI + +EQ +
Sbjct: 812 DCFRRNLSGTNDSRDFDPEMLADMYQAIKTEEIVMPAEQKGTV----------------- 854
Query: 900 FNGKDYEREAYIQVSKQISSKTELVFKNLSKNKDTV---YYAASHVEHVKSIFETLWMSF 956
K + ++K L + +T +Y A + +F W
Sbjct: 855 --------------------KEDYMWKVLLRRGETAEGSFYHAPTGWNDHDLFAVCWGPA 894
Query: 957 LAALTPPFKEYNDIETSDLCLKGIKTSIKIAATFGIDYARASFVGALIQFANLQNL---- 1012
+AAL+ F + + L G + KIAA +G+ + L +F L ++
Sbjct: 895 VAALSYVFDKSEHEQILQKALTGYRKCAKIAAYYGMKEVFDNLCIHLCKFTTLTSMRDGG 954
Query: 1013 ------EEIKI-----------------------KNVYAIITLLEIAVSEGNYMKDSWKD 1043
E++ + K A TL + GN +++ W++
Sbjct: 955 AGGGADEDVDLSAAALLSHSSSPEAVALAFGENHKAQLATRTLFYLVHENGNILREGWRN 1014
Query: 1044 ILVIVSQVERLQLI------------SKG-VDRETVPDVTQARLANHXXXXXXXXXXXXQ 1090
+ + Q+ R +L+ KG V+ + V N
Sbjct: 1015 LFEALLQLFRARLLPAELTEVEDYVDEKGWVNIQRVHQKELPHTRNDSGLLSWFGLGGGA 1074
Query: 1091 NFFDRWTRKATPGEIAQEKHYNQTLSP-------NISKFITSSELVVLIDKIFTNSSALS 1143
+ DR RK T +++ K +Q +S SK++TS+ L L+ I NS+ +
Sbjct: 1075 SEADR--RKPTQEQLSSMKLASQVISECRPSQIVADSKYLTSTSLAELLSSIAANSAQIV 1132
Query: 1144 GSAIVDFIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNMDRIRLEW 1194
A E + S +F L+ +V + N DR+ L W
Sbjct: 1133 EQA---------EPQQKTASLSGEDEDALVFYLELIVAITLENKDRLPLVW 1174
>YJR031c [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1408
Score = 140 bits (352), Expect = 2e-32
Identities = 83/217 (38%), Positives = 118/217 (54%), Gaps = 28/217 (12%)
Query: 689 RKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWL-LNTDGLDLSAVGEYLGEG 747
RKTE + CV+ FN K KKGI I+KGFI+ DS+ IA +L LN L+ +G L +
Sbjct: 541 RKTEFILCVETFNEKAKKGIQMLIEKGFIDSDSNRDIASFLFLNNGRLNKKTIGLLLCD- 599
Query: 748 NEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPN- 806
K S++ F+D F+F L + A+R+ L KFRLPGE Q+I+R + F+ ++ N
Sbjct: 600 -PKKTSLLKEFIDLFDFKGLRVDEAIRILLTKFRLPGESQQIERIVEAFSSKYSADQSND 658
Query: 807 ------------------------VFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEF 842
V AD+ +VL+YSII+LNTD H+ Q+K MT +++
Sbjct: 659 KVELEDKKAGKNGSESMTEDDIIHVQPDADSVFVLSYSIIMLNTDSHNPQVKDHMTFDDY 718
Query: 843 IENNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQH 879
N G NGKD PR Y+ +I+ I EI + E H
Sbjct: 719 SNNLRGCYNGKDFPRWYLHKIYTSIKVKEIVMPEEHH 755
>Hs7662290 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 841
Score = 140 bits (352), Expect = 2e-32
Identities = 78/211 (36%), Positives = 126/211 (58%), Gaps = 8/211 (3%)
Query: 679 DPLQFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLS 738
D F +RK + LFN K +KG+ I++GF+ D + V +A +LL GL
Sbjct: 392 DSPAFSNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPD-TPVGVAHFLLQRKGLSRQ 450
Query: 739 AVGEYLGEGNEK-NISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFA 797
+GE+LG ++ N ++ VD+ +F+ + + ALR F R+ GE QK++R + F+
Sbjct: 451 MIGEFLGNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFS 510
Query: 798 ERFVDQNPNV---FSKADTAYVLAYSIILLNTDLHSTQIK--KKMTLEEFIENNSGIDNG 852
+R+ NP V F DT ++LA++IILLNTD++S +K +KM LE+FI+N G+D+G
Sbjct: 511 QRYCICNPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDG 570
Query: 853 KDLPREYMEQIFEEISNHEIKLLSEQHQAMI 883
+D+PRE + I+E I E+K +E H + +
Sbjct: 571 EDIPREMLMGIYERIRKRELK-TNEDHVSQV 600
>Hs14767357 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 701
Score = 135 bits (341), Expect = 5e-31
Identities = 79/206 (38%), Positives = 121/206 (58%), Gaps = 8/206 (3%)
Query: 685 TAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYL 744
T LRK + LFN KGI I +GFI D + + +A +LL GL +GE+L
Sbjct: 166 TDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPD-TPIGVAHFLLQRKGLSRQMIGEFL 224
Query: 745 GEGNEK-NISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQ 803
G ++ N ++ VD+ +F+++ + ALR F R+ GE QK++R + F++R+
Sbjct: 225 GNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMC 284
Query: 804 NPNV---FSKADTAYVLAYSIILLNTDLHSTQIK--KKMTLEEFIENNSGIDNGKDLPRE 858
NP V F DT ++LA++IILLNTD++S IK +KM LE+FI N G+D+G D+PRE
Sbjct: 285 NPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRE 344
Query: 859 YMEQIFEEISNHEIKLLSEQHQAMIS 884
+ I+E I E+K +E H ++
Sbjct: 345 LVVGIYERIQQKELK-SNEDHVTYVT 369
>YEL022w [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1459
Score = 134 bits (337), Expect = 1e-30
Identities = 76/207 (36%), Positives = 121/207 (57%), Gaps = 18/207 (8%)
Query: 689 RKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDG-LDLSAVGEYLGEG 747
RKTE + C FN K KKGI I+KGFI DS IA++L N + ++ +G L
Sbjct: 559 RKTEFIECTNAFNEKPKKGIPMLIEKGFIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHP 618
Query: 748 NEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFV---DQN 804
++ +S+++ ++ F+F+ L + A+R+ L KFRLPGE Q+I+R + F+ + D +
Sbjct: 619 DK--VSLLNEYIRLFDFSGLRVDEAIRILLTKFRLPGESQQIERIIEAFSSAYCENQDYD 676
Query: 805 PNVFSK------------ADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNG 852
P+ S AD+ ++L+YSII+LNTDLH+ Q+K+ M+ E++ N G N
Sbjct: 677 PSKISDNAEDDISTVQPDADSVFILSYSIIMLNTDLHNPQVKEHMSFEDYSGNLKGCCNH 736
Query: 853 KDLPREYMEQIFEEISNHEIKLLSEQH 879
KD P Y+++I+ I + EI + E H
Sbjct: 737 KDFPFWYLDRIYCSIRDKEIVMPEEHH 763
>Hs14764245 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 1488
Score = 133 bits (334), Expect = 3e-30
Identities = 68/183 (37%), Positives = 117/183 (63%), Gaps = 7/183 (3%)
Query: 697 VKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEK-NISIM 755
+ LFN K +KGI I++GF+ D + V +A ++L GL +GE+LG ++ N ++
Sbjct: 761 LNLFNKKPEKGIQYLIERGFLSD-TPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVL 819
Query: 756 HAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNV---FSKAD 812
VD+ +F+++ + ALR F R+ GE QK++R + F++R+ NP + F D
Sbjct: 820 DCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPD 879
Query: 813 TAYVLAYSIILLNTDLHSTQIK--KKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNH 870
T ++LA++IILLNTD++S +K +KM L++FI+N G+DNG+D+PR+ + I++ I
Sbjct: 880 TIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGR 939
Query: 871 EIK 873
E++
Sbjct: 940 ELR 942
>7303476 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 2040
Score = 132 bits (333), Expect = 4e-30
Identities = 112/406 (27%), Positives = 183/406 (44%), Gaps = 65/406 (16%)
Query: 682 QFETAKLRKTELLNCVKLFNYKTKKGIAESIKKGFIEDD-SSVAIAKWLLNTDGLDLSAV 740
Q K +K L + FN + +KGI + G + + + +A +L GLD +
Sbjct: 636 QLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDPMQVALFLRENPGLDKKMI 695
Query: 741 GEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERF 800
GEY+ + + I+ FVD F+FT L + ALRL+L+ FRLPGE I + F++ +
Sbjct: 696 GEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAPLIFLVLEHFSDHW 755
Query: 801 VDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKK---KMTLEEFIENNSGIDNGKDLPR 857
QN + F+ D A+ LAY+II+LN D H++ K+ MTLE+F +N G++ G+D +
Sbjct: 756 HKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGLNGGEDFDQ 815
Query: 858 EYMEQIFEEISNHEIKLLSEQHQAMISGDATAALPQQSSFGFFNGKDYEREAYIQVSKQI 917
E + Q+F I N EI + +EQ + RE Y
Sbjct: 816 EMLAQVFNAIKNEEIVMPAEQTGLV------------------------RENY------- 844
Query: 918 SSKTELVFKNLSKNKDT---VYYAASHVEHVKSIFETLWMSFLAALTPPFKEYNDIETS- 973
+K L + DT ++ + IF +W + L+AL+ F + ET
Sbjct: 845 ------QWKVLLRRGDTHDGHFHYVHDASYDVEIFNIVWGASLSALSFMFDK--STETGY 896
Query: 974 DLCLKGIKTSIKIAATFGIDYARASFVGALIQFANLQNLEE------------------I 1015
L G S I+A + + + V L +F L + E +
Sbjct: 897 QRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSVEQHEPAPANNETQQAVNFGL 956
Query: 1016 KIKNVYAIITLLEIAVSEGNYMKDSWKDILVIVSQVERLQLISKGV 1061
K A+ T+ + G+ +++SWK IL + Q+ RL+L+ K +
Sbjct: 957 NGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKSL 1002
>7296387 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 1210
Score = 129 bits (323), Expect = 6e-29
Identities = 71/207 (34%), Positives = 126/207 (60%), Gaps = 7/207 (3%)
Query: 688 LRKTELLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGE- 746
+RK + + LFN K +KGI I++GF+E+ +A++L+ GL +GEYLG
Sbjct: 650 IRKRQYRVGLNLFNKKPEKGITYLIRRGFLENTPQ-GVARFLITRKGLSRQMIGEYLGNL 708
Query: 747 GNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPN 806
N+ N++++ F + + + + ALR F FR+PGE QKI+R M F++R+ + N +
Sbjct: 709 QNQFNMAVLSCFAMELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYCECNAD 768
Query: 807 VFSK---ADTAYVLAYSIILLNTDLHSTQIK--KKMTLEEFIENNSGIDNGKDLPREYME 861
+ + +DT +VLA++II+LNTDLH+ +K ++M +E+FI+N GID+ D+ ++ +
Sbjct: 769 IVGRLRSSDTIFVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHDIDKDMLM 828
Query: 862 QIFEEISNHEIKLLSEQHQAMISGDAT 888
I++ + + E K S+ ++ AT
Sbjct: 829 GIYDRVKSDEFKPGSDHVTQVMKVQAT 855
>CE26942 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 393
Score = 113 bits (282), Expect = 3e-24
Identities = 70/218 (32%), Positives = 117/218 (53%), Gaps = 10/218 (4%)
Query: 693 LLNCVKLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNI 752
++N K FN K + + + D A+A W+ +GL SA+GE LG+ +
Sbjct: 64 VVNGRKKFNQDPWKALDWLASRNVVAKDPQ-ALALWMKAGEGLSKSAIGEILGDNRPFAL 122
Query: 753 SIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKAD 812
+ F + + ++ IV ALR +L FRLPGE QKI+R + KFAE + +QNP+ + AD
Sbjct: 123 ETLDRFTKEHKLHDVPIVPALRQYLFSFRLPGESQKINRILEKFAEVYANQNPS-YGNAD 181
Query: 813 TAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEI 872
A+ +AYS I++NT LH+ +K K +LE++IE N + + E + +++E +S +
Sbjct: 182 QAHTVAYSCIMVNTLLHNPNVKDKPSLEKYIEMNEQLLEKGAITIEQLTEVYESVSVTQF 241
Query: 873 KLLSE--------QHQAMISGDATAALPQQSSFGFFNG 902
K+ E + ++ + L +QSS F+G
Sbjct: 242 KIPDEVSTSGKGTVNDILLHAEREGWLFKQSSNPLFSG 279
>7300886 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 900
Score = 110 bits (276), Expect = 2e-23
Identities = 55/182 (30%), Positives = 105/182 (57%), Gaps = 4/182 (2%)
Query: 717 IEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLF 776
++ S++ +AK L + DG S V +L + N+ + ++ ++ F F S+ ALR F
Sbjct: 420 VDMPSAIRLAKRLHSLDGFKKSDVSRHLSKNNDFSRAVADEYLKHFTFEKKSLDQALREF 479
Query: 777 LQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKK 836
LQ+F L GE Q+ +R ++ F++RF+D NP F+ D + L +I+LLNTDLH I +K
Sbjct: 480 LQQFSLSGETQERERVLVHFSKRFLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQNINRK 539
Query: 837 MTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQHQAMISGDATAALPQQSS 896
M+ EF++N + +++G++ P++ ++ +++ I ++ ++ +GD S+
Sbjct: 540 MSCAEFVDNLADLNDGENFPKDVLKSLYQAIKTKPLEWALDEE----AGDLQQQRANNSA 595
Query: 897 FG 898
G
Sbjct: 596 LG 597
>Hs4506161 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 645
Score = 107 bits (266), Expect = 2e-22
Identities = 55/175 (31%), Positives = 101/175 (57%), Gaps = 1/175 (0%)
Query: 707 GIAESIKKGFIED-DSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFT 765
G +++ G D +++ +AK L DG + V +LG+ N+ + + ++ F FT
Sbjct: 163 GSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFT 222
Query: 766 NLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLN 825
+++ ALR+FL++ L GE Q+ +R + F++R+ NP S D A+ L +++LLN
Sbjct: 223 GMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLN 282
Query: 826 TDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQHQ 880
TDLH I K+MT +FI N G+++G D PRE ++ ++ I N +++ ++ +
Sbjct: 283 TDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEE 337
>Hs6912706 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 1056
Score = 100 bits (248), Expect = 3e-20
Identities = 53/168 (31%), Positives = 92/168 (54%)
Query: 725 IAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPG 784
+A L +G S V YL + N+ + ++ ++ F+F S+ ALR FLQ L G
Sbjct: 591 LASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSG 650
Query: 785 EGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIE 844
E Q+ +R + +F+ RF NP +F D+ + L +I+LLNTDLH I K M+ +EFI
Sbjct: 651 ETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFIT 710
Query: 845 NNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQHQAMISGDATAALP 892
N +G+ +G + P+E ++ ++ I + +++ ++ A +LP
Sbjct: 711 NLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLP 758
>Hs7662396 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 534
Score = 99.0 bits (245), Expect = 6e-20
Identities = 53/171 (30%), Positives = 97/171 (55%), Gaps = 2/171 (1%)
Query: 705 KKGIAESIKKGFIED-DSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFE 763
+K E++ G + +++ +AK L D S V ++LG+ NE + + ++ F+
Sbjct: 53 EKETPENLSNGTSSNVEAAKRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFD 112
Query: 764 FTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIIL 823
FT +++ +LR F + F L GE Q+ +R ++ F+ R+ NP+ + D + L +I+L
Sbjct: 113 FTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIML 172
Query: 824 LNTDLHS-TQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEISNHEIK 873
LNTDLH I KKMT +EFI N G++ G D ++ ++ ++ I N +++
Sbjct: 173 LNTDLHGHVNIGKKMTCQEFIANLQGVNEGVDFSKDLLKALYNSIKNEKLE 223
>CE12328 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 614
Score = 98.2 bits (243), Expect = 1e-19
Identities = 64/192 (33%), Positives = 104/192 (53%), Gaps = 13/192 (6%)
Query: 703 KTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNIS-IMHAFVDQ 761
K ++G+ GF+++ S ++A L GL S +GEY+G + S ++ F
Sbjct: 212 KPERGVQLLTAWGFVKN-SPDSLASLLFGRRGLSKSMIGEYIGTLHSPYHSLVLKYFTAL 270
Query: 762 FEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNPNVFSKA----DTAYVL 817
+ L + ALR +Q F LP E +KIDR + FA + NP S DT ++L
Sbjct: 271 IDIRGLEVDVALRKAMQFFILPKEAEKIDRIIQAFALHYSKSNPKRTSHYRGGWDTIHLL 330
Query: 818 AYSIILLNTDLHSTQIKKKMTLEEFIENNSGID------NGKDLPREYMEQIFEEISNHE 871
+++II+LNTDLHS +K++MT +F++N G D NG+D+ R+ +E I++ I E
Sbjct: 331 SFAIIMLNTDLHSPNVKQRMTQADFVKNLRGQDKISGEKNGEDIDRKTLEGIYDRIKKDE 390
Query: 872 IKLLSEQHQAMI 883
+K + H A +
Sbjct: 391 LK-AGDDHVAQV 401
>Hs14150035 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 771
Score = 93.6 bits (231), Expect = 3e-18
Identities = 46/149 (30%), Positives = 87/149 (57%)
Query: 725 IAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPG 784
+A+ L + +G V LG+ NE + + ++ F+F+ L++ ALR FL+ F L G
Sbjct: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376
Query: 785 EGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIE 844
E Q+ +R + F+ R+ NP+ + D + L +++LLNTDLH I KKM+ ++FI
Sbjct: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436
Query: 845 NNSGIDNGKDLPREYMEQIFEEISNHEIK 873
N +++G+D ++ ++ ++ I N +++
Sbjct: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLE 465
>Hs22064762 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 113
Score = 91.3 bits (225), Expect = 1e-17
Identities = 48/96 (50%), Positives = 66/96 (68%), Gaps = 1/96 (1%)
Query: 698 KLFNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHA 757
K FN KKGI I+ +++ IA++L +GL+ +A+G+YLGE +E NI ++HA
Sbjct: 12 KKFNMDPKKGIQFLIENDLLKNTCE-DIAQFLYKGEGLNKTAIGDYLGERDEFNIQVLHA 70
Query: 758 FVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFM 793
FV+ EFT+L++V ALR FL FRLPGE QKIDR M
Sbjct: 71 FVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMM 106
>CE29066 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 818
Score = 87.8 bits (216), Expect = 1e-16
Identities = 50/170 (29%), Positives = 88/170 (51%), Gaps = 2/170 (1%)
Query: 725 IAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPG 784
IA+ L + V + L E NE + I+ +++ F+F+ I +ALR FL + L G
Sbjct: 389 IARNLYELKNCTSTQVADRLNEQNEFSFLILVKYLELFQFSTTRIDAALREFLSRVELRG 448
Query: 785 EGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIE 844
E +R + F+ R+++ NP +F D + L +++LLN+DLH + KKMT +FI
Sbjct: 449 ESSARERLLRVFSARYLECNPAIFDSLDEVHTLTCALLLLNSDLHGPNMGKKMTARDFIT 508
Query: 845 NNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQHQAMISGDATAALPQQ 894
N + G RE ++ +F+ I ++ I L + + +G + +Q
Sbjct: 509 NIA--HTGCTFKREMLKTLFQSIKDNAISLQNSAKNSTANGSVASTSRRQ 556
>CE19234 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 816
Score = 87.8 bits (216), Expect = 1e-16
Identities = 50/170 (29%), Positives = 88/170 (51%), Gaps = 2/170 (1%)
Query: 725 IAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPG 784
IA+ L + V + L E NE + I+ +++ F+F+ I +ALR FL + L G
Sbjct: 387 IARNLYELKNCTSTQVADRLNEQNEFSFLILVKYLELFQFSTTRIDAALREFLSRVELRG 446
Query: 785 EGQKIDRFMLKFAERFVDQNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIE 844
E +R + F+ R+++ NP +F D + L +++LLN+DLH + KKMT +FI
Sbjct: 447 ESSARERLLRVFSARYLECNPAIFDSLDEVHTLTCALLLLNSDLHGPNMGKKMTARDFIT 506
Query: 845 NNSGIDNGKDLPREYMEQIFEEISNHEIKLLSEQHQAMISGDATAALPQQ 894
N + G RE ++ +F+ I ++ I L + + +G + +Q
Sbjct: 507 NIA--HTGCTFKREMLKTLFQSIKDNAISLQNSAKNSTANGSVASTSRRQ 554
>Hs15812208 [U] KOG0929 Guanine nucleotide exchange factor
Length = 319
Score = 74.7 bits (182), Expect = 1e-12
Identities = 52/173 (30%), Positives = 87/173 (50%), Gaps = 12/173 (6%)
Query: 700 FNYKTKKGIAESIKKGFIEDDSSVAIAKWLLNTDGLDLSAVGEYLGEGNEKNISIMHAFV 759
FN +G+ + KG + DDS IAK++ T L+ + YL E + ++ V
Sbjct: 146 FNANPDEGVNYFMSKGIL-DDSPKEIAKFIFCTRTLNWKKLRIYLDERRD----VLDDLV 200
Query: 760 DQFEFTNLSIVSALRLFLQKFRLPGE-GQKIDRFMLKFAERFVDQNPNVFSKA----DTA 814
F N + +ALR F + P E G+ ++ + KF+ RF NP++ + D
Sbjct: 201 TLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSPDAV 260
Query: 815 YVLAYSIILLNTDLHSTQIKKKMTLEEFIENNSGIDNGKDLPREYMEQIFEEI 867
YVL YS+ILL+ DL S +K KM+ EFI N +++ +++ +++ I
Sbjct: 261 YVLCYSLILLSIDLTSPHVKNKMSKREFIRNTRRA--AQNISEDFVGHLYDNI 311
>SPAC26F1.01 [U] KOG0929 Guanine nucleotide exchange factor
Length = 657
Score = 68.9 bits (167), Expect = 7e-11
Identities = 33/105 (31%), Positives = 62/105 (58%), Gaps = 1/105 (0%)
Query: 744 LGEGNEKNISI-MHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVD 802
L +G + + + ++ F +S+ ALR FL + LP E Q+IDR + F++++
Sbjct: 26 LSQGTSSLLKLCLRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFH 85
Query: 803 QNPNVFSKADTAYVLAYSIILLNTDLHSTQIKKKMTLEEFIENNS 847
NP+++ +D Y+L +S+++L+TD + ++KMT EFI N +
Sbjct: 86 CNPDLYDSSDECYILTFSLMILHTDFFNIHNRQKMTRAEFISNTN 130
>ECU10g1140 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1063
Score = 67.4 bits (163), Expect = 2e-10
Identities = 37/153 (24%), Positives = 75/153 (48%), Gaps = 11/153 (7%)
Query: 736 DLSAVGEYLGEGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLK 795
DL +G +L + KN + F F+F ++ I+ LR +L F L EGQ I R +
Sbjct: 338 DLKKLGGFLCK--LKNEDYLRIFTGTFDFLDMDILDGLRTYLLSFHLSAEGQIIHRVVEA 395
Query: 796 FAERFVDQNPNVFSKADT---------AYVLAYSIILLNTDLHSTQIKKKMTLEEFIENN 846
+A+++ N + + D + LA+S ++LNT H+ +K K T +++++
Sbjct: 396 YADKYYSDNVDACTFMDITRDKRTKEFVFNLAFSFLVLNTKFHNPNVKAKPTFRDYMKDF 455
Query: 847 SGIDNGKDLPREYMEQIFEEISNHEIKLLSEQH 879
+ + EY+E +++ + ++ ++ H
Sbjct: 456 TAEEIPPSFSEEYLESMYQSVKKRPLEFPAKNH 488
>YPR095c [U] KOG0929 Guanine nucleotide exchange factor
Length = 1226
Score = 61.2 bits (147), Expect = 1e-08
Identities = 40/154 (25%), Positives = 75/154 (47%), Gaps = 17/154 (11%)
Query: 735 LDLSAVGEYLG------EGNEKNISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQK 788
+ L+ G+++G + K + + + FEF N + ALR L LP E Q+
Sbjct: 468 IKLAPYGKFIGIILTEKDDEFKKNCLNYLLTNCFEFKNDPLDIALRKLLMFLELPKETQQ 527
Query: 789 IDRFMLKF------AERFVDQNPNV---FSKADTAYVLAYSIILLNTDLHSTQIKKKMTL 839
IDR ++ F A++ + + +S AD Y +A+S+++L+TD + K KMT
Sbjct: 528 IDRLIMAFSFAYYKAQKSYSKKKGIECPWSNADQVYFIAFSLLMLHTDYFNPNNKSKMTK 587
Query: 840 EEFIE--NNSGIDNGKDLPREYMEQIFEEISNHE 871
+F++ +N G ++P + +E ++ E
Sbjct: 588 HDFVDLVHNDKYSGGNEIPMAVLTYFYENVTAKE 621
>SPAC11E3.11c [U] KOG0929 Guanine nucleotide exchange factor
Length = 942
Score = 61.2 bits (147), Expect = 1e-08
Identities = 31/133 (23%), Positives = 70/133 (52%), Gaps = 12/133 (9%)
Query: 751 NISIMHAFVDQFEFTNLSIVSALRLFLQKFRLPGEGQKIDRFMLKFAERFVDQNP-NVFS 809
N +++ ++ ++F N I+ +LR+ + GE Q++D F+ +F+ ++ NP +F
Sbjct: 366 NKAVLKHYISLYDFENTDILQSLRMICGNLYVHGETQELDHFLGEFSNQWCRTNPKGLFC 425
Query: 810 KADTAYVLAYSIILLNTDLHSTQI--KKKMTLEEFIEN---------NSGIDNGKDLPRE 858
+ +A+S++LLNTDLH ++ ++M+ +F+EN N D ++
Sbjct: 426 NPQIVHSIAFSLLLLNTDLHIAELSASERMSRNQFVENTYRSIKQALNDSFDGNEEKKNA 485
Query: 859 YMEQIFEEISNHE 871
+ ++ +++E
Sbjct: 486 FFLSSYKSFASNE 498
>CE17656 [S] KOG1848 Uncharacterized conserved protein
Length = 1646
Score = 55.1 bits (131), Expect = 1e-06
Identities = 82/459 (17%), Positives = 175/459 (37%), Gaps = 47/459 (10%)
Query: 1096 WTRKATPGEIAQEKHYNQTLSPNISKFITSSELV------VLIDKIFTNSSALSGSAIVD 1149
W P ++ Q + + N+ +T++ L L+DK+ +AL + +
Sbjct: 683 WLLAMRPTQVGQFERETRDDHSNVPTVVTNAALSDIAMLSSLMDKVAPAIAALPDKSFLS 742
Query: 1150 FIKALTEVSFEEIESSQNATTPRMFSLQKMVDVCYYNMDRIRLEWTPIWNVMGEAFNRIA 1209
I AL +S E + + +F L + VC ++ R+++ W N F ++
Sbjct: 743 VIDALIRLSDESLAVAATGRESSLFPLAVLYKVCSLSLMRLQVFWQKAAN----HFIKVC 798
Query: 1210 TESNLAVVFFAIDSLRQLSMRFLDIEELTGFEFQLDFLKPFEHTVENTRDIDVQEMCIEC 1269
+++++ +A +L L+ + + + Q + + + + I V+ ++C
Sbjct: 799 NHTSVSMRDWAAVALTSLAKHAVKSKTSMDAKSQQEMIISSLLALCSIPHIQVRRRQLDC 858
Query: 1270 FHNFILTKSGKIKS-GWKPILKSLQYTAQSPNE---RIVTRTY---ELVSYDIVKDHFYX 1322
+ + T + S W +++ + S E +V + Y LVS D ++ +
Sbjct: 859 VMSLMQTDGAFLLSTSWPNVIQIISAIIDSDTECELSLVRQGYLGLRLVSSDFLQSIPFD 918
Query: 1323 XXXXXXXXXXXXXXXKEITKNQKHQKLALHSLETLKRITNQVADLCFKNHDHQLLQGKDE 1382
+K Q ++L +L L I+ D ++ + G D
Sbjct: 919 CISGLVEAIS------RYSKQNTDQNISLSALTLLWTIS----DFIYRKMESV---GNDA 965
Query: 1383 FEDVWLPLLFCFNDTIMTAVDLEVRSRALNYMFDALVANGAEFDEEFWNKICTQLLFPIF 1442
E VW+ L C +++ + + VR A + + A+G W+ + Q++ P+
Sbjct: 966 SEAVWMVLYTCLSESCVDS-RFAVRKSACQTLLQTVTAHGHALRSAAWHSVIWQIMIPLL 1024
Query: 1443 GIL----------SKHWEVNQFNSHDDMSVWLSTTLIQALRNMVALFTHYFESLNGLLD- 1491
+ + E+ +S D + T I + + +F +SL L D
Sbjct: 1025 DKVRSQTRCASTEKSNGELIMHHSRDTEQKQWTETCIHTISAISKIFNSQRKSLLALNDF 1084
Query: 1492 -----GVLGLMVSCICQENDTIARIGRSCLQQLILQNMS 1525
LG + C EN ++ Q+++L +S
Sbjct: 1085 GAVWEAFLGYLDWAACYENAELSLSAIRSYQEVLLGKIS 1123
>7290667 [U] KOG1846 Uncharacterized conserved protein contains Sec7 domain
Length = 2045
Score = 53.5 bits (127), Expect = 3e-06
Identities = 41/172 (23%), Positives = 72/172 (41%), Gaps = 20/172 (11%)
Query: 1142 LSGSAIVDFIKALTEVSFEEIESSQNA-----------------TTPRMFSLQKMVDVCY 1184
LS ++ F+K L S +++ SQ A + P L ++ DV
Sbjct: 998 LSLPSLCQFLKHLCRASRDQLYKSQVARKGSRIWWPSKGWKKLDSLPMSLLLHRIGDVTL 1057
Query: 1185 --YNMDRIRLEWTPIWNVMGEAFNRIATESNLAVVFFAIDSLRQLSMRFL-DIEELTGFE 1241
+ R L +W + G A + + AI+ + + L + EL F
Sbjct: 1058 KVFRSSRPLLHVLKVWAITGPHLMDAACHRDRMISKRAIEYIHDIITALLVEQSELPYFH 1117
Query: 1242 FQLDFLKPFEHTVENTRDIDVQEMCIECFHNFILTKSGKIKSGWKPILKSLQ 1293
F LKPFE+ + D+DVQ+ + C + + +I+SGW+P+ +L+
Sbjct: 1118 FNEALLKPFENLLSMDTDVDVQDQIVACLYEVVEAHRTEIRSGWRPLFGTLR 1169
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.133 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,777,631
Number of Sequences: 60738
Number of extensions: 3787179
Number of successful extensions: 12019
Number of sequences better than 1.0e-05: 49
Number of HSP's better than 0.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 11712
Number of HSP's gapped (non-prelim): 140
length of query: 1848
length of database: 30,389,216
effective HSP length: 121
effective length of query: 1727
effective length of database: 23,039,918
effective search space: 39789938386
effective search space used: 39789938386
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)