ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV4488 good B KOG4191 Chromatin structure and dynamics Histone acetyltransferases PCAF/SAGA/ADA, subunit TADA3L/NGG1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV4488 1524750 1526663 638
(638 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR176w [B] KOG4191 Histone acetyltransferases PCAF/SAGA/ADA sub... 597 e-170
SPBC28F2.10c [B] KOG4191 Histone acetyltransferases PCAF/SAGA/AD... 171 3e-42
Hs5454104 [B] KOG4191 Histone acetyltransferases PCAF/SAGA/ADA s... 56 1e-07
7293417 [B] KOG4191 Histone acetyltransferases PCAF/SAGA/ADA sub... 54 7e-07
>YDR176w [B] KOG4191 Histone acetyltransferases PCAF/SAGA/ADA subunit
TADA3L/NGG1
Length = 702
Score = 597 bits (1540), Expect = e-170
Identities = 336/708 (47%), Positives = 442/708 (61%), Gaps = 84/708 (11%)
Query: 1 MSRNTRRGKGIREQK--RDDAGLHEPSNILNSMLKSLDLTFENDIGLLNGKYVRSVPEKP 58
M R+ RRGK + +K + + G + PS +L+SMLK+LDLTFE DIG+LNGK VRS+P K
Sbjct: 1 MPRHGRRGKLPKGEKLPKKEGGDNTPSKLLSSMLKTLDLTFERDIGMLNGKSVRSIPNKK 60
Query: 59 VLQTTKDQLENLGKCLEKIAASDQENLDLIKEMREDIIRLE-DXXXXXXXXXXXXXXXXX 117
L + QL++L + L IA DQE ++ ++++R+ + +
Sbjct: 61 TLLELQSQLDSLNEILGTIARGDQETIEALRKIRDSKNEKQANDEKQETSNADGQHESST 120
Query: 118 XXXXXDSINKKLD-------------------ESSEVVSDKRSITEENEETD-------- 150
+ I+K + ES + +D + E NE+ D
Sbjct: 121 ATEETNIIDKGVQSPPKPPPSNEISGTIENDVESIKQAADNMAKEEINEDKDLQVHRDQP 180
Query: 151 --KRPQDTIEEAEVLSSDGHI---SKKAKLDIDKMENDPNIRNPKSEFVVSQTLPAAAMR 205
KRP D+ E ++ +KK K+D+DKMENDP ++NPKSEFVVSQTLP AA
Sbjct: 181 REKRPFDSETENRATENENTQRPDNKKQKIDVDKMENDPTVKNPKSEFVVSQTLPRAAAA 240
Query: 206 LGLFQEEGLEATGEEYLKKKYGVVSYPTNDLKELLPGELPDMDFSKPKPTNQIQFNTFLS 265
LGLF EEGLE+TGE++LKKKY V SYPTNDLK+LLPGELPDMDFS PKPTNQIQFNTFL+
Sbjct: 241 LGLFNEEGLESTGEDFLKKKYNVASYPTNDLKDLLPGELPDMDFSHPKPTNQIQFNTFLA 300
Query: 266 SIEAFYREFNDDDIKFLQNKFIMPQNLQFVKSYDPEVTPYTIPKLGPLYTDVWLKEDNNQ 325
+E F+++ +DD++KFL+ K+I+P +LQF K+YDPEV P+ IPKLGPLYTDVW K++N++
Sbjct: 301 FVENFFKDLSDDNLKFLKMKYIIPDSLQFDKTYDPEVNPFIIPKLGPLYTDVWFKDENDK 360
Query: 326 NIA-NLTXXXXXXXXXXXXXXXGNDISDGVLDNEEVSCGPLVSRLLSAILKDD------- 377
N A N++ D L++ +SCGPL+SRLLSA+LKDD
Sbjct: 361 NSAYKKPSPYSNDASTILPKKSANELDDNALESGSISCGPLLSRLLSAVLKDDNDKSELQ 420
Query: 378 ------------------------------DIIAPKEELPTNPTLDSSVSTPVSELEHVT 407
D+ +E P+ T D+ + S +
Sbjct: 421 SSKIIRDGGLPRTGGEDDIQSFRNNNNDTVDMTLSQENGPSVQTPDNDIDEEASFQAKLA 480
Query: 408 PSSSSSYG----IFKQHGAIANNSNIDYVSFEERLKRELKYVGIYMNLPREEGK-TREDP 462
+ S+ G + +Q G I N N+DY +FEERLKRELKYVGIYMNLP++E +DP
Sbjct: 481 ENKGSNGGTTSTLPQQIGWITNGINLDYPTFEERLKRELKYVGIYMNLPKDENNPNSDDP 540
Query: 463 DWLTGREDDEISAELRELQSTLRQVTTKNTKRKAMLLPLLERMLAWQEYCTILDNLDKQV 522
DW+TGREDDEISAELRELQ TL+QVT KN KRKA L+PL+ER LAWQEY +IL++LDKQ+
Sbjct: 541 DWVTGREDDEISAELRELQGTLKQVTKKNQKRKAQLIPLVERQLAWQEYSSILEDLDKQI 600
Query: 523 DQAYIKRIRAPKNKKKRQYTPGPDSLATGSTSXXXXXXXXXXXXNSSLKSLLDKRQRWIS 582
DQAY+KRIR PK K+K+ +T +++ TG+TS NSSLKSLLDKRQRWI+
Sbjct: 601 DQAYVKRIRVPK-KRKKHHTAASNNVNTGTTS----QIAQQKAANSSLKSLLDKRQRWIN 655
Query: 583 KIGPLFDKPEVMKRIPRDSVFKDIDQDXXXXXADVFSNNANGKEEELN 630
KIGPLFDKPE+MKRIP +SVFKD+DQ+ ADVF+ N N K+ ELN
Sbjct: 656 KIGPLFDKPEIMKRIPNESVFKDMDQEEDEDEADVFAQNTN-KDVELN 702
>SPBC28F2.10c [B] KOG4191 Histone acetyltransferases PCAF/SAGA/ADA subunit
TADA3L/NGG1
Length = 551
Score = 171 bits (433), Expect = 3e-42
Identities = 144/516 (27%), Positives = 235/516 (44%), Gaps = 81/516 (15%)
Query: 123 DSINKKLDESSEVVSDKRSITEENEETDKRPQDTIEEAEVLSSDGHISKKAKLDIDKMEN 182
+ + +D E D+ S+ + E+ ++ +D +E+ E+ + ++K+
Sbjct: 73 EELESHVDSEIETSKDESSVNKVEEKVEEFKEDNVEQ-EIKQKRSLSESPQESMLEKVSK 131
Query: 183 DPNIRNPKSEFVVSQTLPAAAMRLGL------FQEEGL-------------------EAT 217
P + +E + + + L L Q GL ++
Sbjct: 132 KPKVSEAHNEEISPENVETIENELDLPVKGKDEQTTGLVYKNANDLLTGSLLSFIVDDSF 191
Query: 218 GEEYLKKKYGVVSYPTNDLKELLPGELPDMDFSKPKPTNQIQFNTFLSSIEAFYREFNDD 277
E KK V S+PT+D++ L+ G DFS KP NQI +TF SS++ ++R FNDD
Sbjct: 192 SYEQKKKLLCVDSFPTSDVRSLVAGTPATDDFSHNKPNNQISISTFYSSLDPYFRAFNDD 251
Query: 278 DIKFLQNKFIMPQNLQFVKSYDPEVTPYTIPKLGPLYTDVWLKEDNNQNIANLTXXXXXX 337
DI FL+ F + + Y IP LG Y D+ ED N+ +
Sbjct: 252 DIAFLKKGFDVSSS-------------YNIPPLGERYYDL-TPEDEMTNLCANSIYQNLQ 297
Query: 338 XXXXXXXXXGNDISDGVLDNEEVSCGPLVSRLLSAIL----KDDDIIAPKEELPTNPTLD 393
N+ +D V +EEV CGPL RL+++++ ++D+ E+ P+ +
Sbjct: 298 TSAQGSLEAFNE-ADTV--SEEVRCGPLTERLMASLIPCYTQNDE-----EQKPSIAVGE 349
Query: 394 SSVSTPVSELEHVTPSSSSSYGIFKQHGAIANNSNIDYVSF---EERLKRELKYVGIYMN 450
+ + SE + +S GI + +I S E+RL+ LK +GI +
Sbjct: 350 FAETDSGSEKSKI---GTSIDGIESGNNEYTEQPDIQESSLSICEDRLRYTLKQLGILYD 406
Query: 451 LPREEGKTREDPDWLTGREDDEISAELRELQSTLRQVTTKNTKRKAMLLPLLERMLAWQE 510
D DW + R+DDEISA LR L + L+ V+ +N K + LL +L +A+QE
Sbjct: 407 ---------GDVDW-SKRQDDEISATLRSLNARLKVVSDENEKMRNALLQMLPEEMAFQE 456
Query: 511 YCTILDNLDKQVDQAYIKRIRAPKNKKKRQYTPGPDSLATGSTSXXXXXXXXXXXXNSSL 570
+ ++D+LDKQ++QAY+KR R+ K KKKR T D + + +TS +
Sbjct: 457 FQNVMDDLDKQIEQAYVKRNRSLKVKKKRIVT---DKIGSSATSGSF----------PVI 503
Query: 571 KSLLDKRQRWISKIGPLFDKPEVMKRIPRDSVFKDI 606
KSL+DKR W+ K+ PLF S+F D+
Sbjct: 504 KSLMDKRSMWLEKLQPLFQDKLTQHLGSPTSIFNDL 539
>Hs5454104 [B] KOG4191 Histone acetyltransferases PCAF/SAGA/ADA subunit
TADA3L/NGG1
Length = 432
Score = 56.2 bits (134), Expect = 1e-07
Identities = 70/309 (22%), Positives = 124/309 (39%), Gaps = 49/309 (15%)
Query: 243 ELPDMDFSKPKPTNQIQFNTFLSSIEAFYREFNDDDIKFLQNKFIMPQNLQFVKSYDPEV 302
E D P+ N F +S+E + + ++++ L+ + +K + E
Sbjct: 134 EFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLE---------ELLKPPEDEA 184
Query: 303 TPYTIPKLGPLYTDVWLKEDNNQNIANLTXXXXXXXXXXXXXXXGNDIS----DGVLDNE 358
Y IP LG Y+ W +ED + + ++ D +L
Sbjct: 185 EHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKS 244
Query: 359 EVS---------CGPLVSRLLSAILKDDDIIAPKEELPTNPTLDSSVSTPVSELEHVTPS 409
E G L RLL A++ +++II+P E+ P +S E
Sbjct: 245 EAQHEQPEDGCPFGALTQRLLQALV-EENIISPMEDSPI---------PDMSGKESGADG 294
Query: 410 SSSSYGIFKQHGAIANNSNIDYVSFEERLKRELKYVGIYMNLPREEGKTREDPDWLTGRE 469
+S+S + ++ + S E R+K EL I L E + ED
Sbjct: 295 ASTSPRNQNKPFSVPHTK-----SLESRIKEEL----IAQGLLESEDRPAED-------S 338
Query: 470 DDEISAELRELQSTLRQVTTKNTKRKAMLLPLLERMLAWQEYCTILDNLDKQVDQAYIKR 529
+DE+ AELR+ Q+ L+ ++ N +K LL L + ++ QE + D +V A+ ++
Sbjct: 339 EDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAF-RK 397
Query: 530 IRAPKNKKK 538
I A + KK+
Sbjct: 398 IMAARQKKR 406
>7293417 [B] KOG4191 Histone acetyltransferases PCAF/SAGA/ADA subunit
TADA3L/NGG1
Length = 556
Score = 53.9 bits (128), Expect = 7e-07
Identities = 68/280 (24%), Positives = 127/280 (45%), Gaps = 34/280 (12%)
Query: 261 NTFLSSIEAFYREFNDDDIKFLQNKFIMPQNLQFVKSYDPEVTPYTIPKLGPLYTDVWLK 320
N F S+E + ++D++ + + + + P V P +P LGP Y+ VW +
Sbjct: 263 NKFWLSVEPYCMPLTNEDLRLIDDLL--------EQYWGPLVPP--VPPLGPHYSTVWAQ 312
Query: 321 EDNNQNIANLTXXXXXXXXXXXXXXXGNDISDGVLDNEEVSCGPLVSRLLSAILKDDDII 380
ED I L ++G++D E GPL RL+SA++++ +
Sbjct: 313 ED----IKALQPGGARIKSNNSSGMLKK--AEGMVD--ESITGPLTQRLVSALMEESLMT 364
Query: 381 APKEELPTNPTLDSSVSTPVSELEHVTPSSSSSYGIFKQHGAIANNSNIDY-VSFEERLK 439
P E+ +S+ S+ +E H SSS++ G + + + + V E+RLK
Sbjct: 365 LPSEQAAVGEHSNSTTSSS-NENTHSHSSSSANAAAAAASGNFRSLAMMKHGVGIEQRLK 423
Query: 440 RELKYVGIYMNLPREEGKTREDPDWLTGREDDEISAELRELQSTLRQVTTKNTKR-KAML 498
+ L G+ + E ED D + E ++ E+ ST+ Q ++ KR +A+
Sbjct: 424 KTLIENGL---IDASEFAAHEDVDEVL-MEIKRVTTEI----STISQFNSEELKRLRAVA 475
Query: 499 LPLLERMLAWQEYCTILDNLDKQVDQAYIKRIRAPKNKKK 538
++R+ Q+ LD +D+++ + Y KR+ + K+K
Sbjct: 476 SEEIKRIAIKQK----LDMVDQEILECY-KRMLQYRAKRK 510
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.310 0.132 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,094,655
Number of Sequences: 60738
Number of extensions: 1613191
Number of successful extensions: 4640
Number of sequences better than 1.0e-05: 4
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 4628
Number of HSP's gapped (non-prelim): 6
length of query: 638
length of database: 30,389,216
effective HSP length: 113
effective length of query: 525
effective length of database: 23,525,822
effective search space: 12351056550
effective search space used: 12351056550
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)