ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV4582 good BK KOG2684 Chromatin structure and dynamics Sirtuin 5 and related class III sirtuins (SIR2 family)
r_klactIV4582 good BK KOG2684 Transcription Sirtuin 5 and related class III sirtuins (SIR2 family)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV4582 1562984 1564180 399
(399 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR191w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 298 1e-80
SPAC1783.04c [BK] KOG2684 Sirtuin 5 and related class III sirtui... 192 1e-48
YOR025w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 161 1e-39
ECU03g0460 [BK] KOG2684 Sirtuin 5 and related class III sirtuins... 103 3e-22
7298007 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 75 2e-13
Hs7657575 [BK] KOG2684 Sirtuin 5 and related class III sirtuins ... 71 2e-12
CE06302 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 63 7e-10
YOL068c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 60 6e-09
SPBC16D10.07c [BK] KOG2684 Sirtuin 5 and related class III sirtu... 60 7e-09
YDL042c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 59 1e-08
SPCC132.02 [BK] KOG2682 NAD-dependent histone deacetylases and c... 57 6e-08
Hs6912660 [BK] KOG2682 NAD-dependent histone deacetylases and cl... 55 2e-07
YPL015c [BK] KOG2682 NAD-dependent histone deacetylases and clas... 54 5e-07
Hs13775602 [BK] KOG2682 NAD-dependent histone deacetylases and c... 52 2e-06
Hs13775600 [BK] KOG2682 NAD-dependent histone deacetylases and c... 52 2e-06
>YDR191w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 370
Score = 298 bits (762), Expect = 1e-80
Identities = 164/390 (42%), Positives = 225/390 (57%), Gaps = 38/390 (9%)
Query: 13 LTPPSSSVKKHDLKAGDLKELSIKPRKLINDLXXXXXXXXXXXXLCDSPTTRSLPQTTRK 72
+TPPS++ KK + + ++KPR+L+ L RK
Sbjct: 9 ITPPSTAEKKPQTE--NRCNENLKPRRLLPQLKKSVR--------------------NRK 46
Query: 73 PRLKYRPELDTVFPLDNYVEGSAKSSS------KDAEFLTYVLSYSKRIXXXXXXXXXXX 126
PRL YRPEL++VF LD YV+ + S S +DA F++Y L+YSKR+
Sbjct: 47 PRLSYRPELNSVFDLDAYVDSTHLSKSQRHHMDRDAGFISYALNYSKRMVVVSGAGISVA 106
Query: 127 XXIPDFRSANGLFTTLKSSSPNVKSGKDLFDFNHVYXXXXXXXXXXXXXXKLHSLSCTSK 186
IPDFRS+ G+F+T+ N SGKDLFD+N VY L LS +
Sbjct: 107 AGIPDFRSSEGIFSTV-----NGGSGKDLFDYNRVYGDESMSLKFNQLMVSLFRLSKNCQ 161
Query: 187 PTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANE--SPKNPQVVQLHGSIHHMSC 244
PT +H +N+ ++ R+Y+QNIDGL+T+ S N + P VQLHGSI HM C
Sbjct: 162 PTKFHEMLNEFARDGRLLRLYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMEC 221
Query: 245 MKCRKKYDMDPSMFKTDE--DAETGEIVPQCPECKEFESVRSVCGKRLQGVGRLKPSVVL 302
KC DP +FK D+ D+ T EI+P CP+C+E+E+VR + G R GVG+L+P V+L
Sbjct: 222 NKCLNIKPFDPELFKCDDKFDSRT-EIIPSCPQCEEYETVRKMAGLRSTGVGKLRPRVIL 280
Query: 303 YNEYHPEGDIISEMMNKDLKSNPDALLIVGTSLKIPGVRQMVKQFATKVRAKKGFIIWVN 362
YNE HPEGD I E+ N DLK D L+IVGTSLKIPGV+ + +QFA KV A +G ++++N
Sbjct: 281 YNEVHPEGDFIGEIANNDLKKRIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGIVLYLN 340
Query: 363 NELPPPNIKTLLNRCDLVVLGDCQNLPVLM 392
+PP N+ L DLVVLGDCQ++ L+
Sbjct: 341 TSMPPKNVLDSLKFVDLVVLGDCQHVTSLL 370
>SPAC1783.04c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 415
Score = 192 bits (487), Expect = 1e-48
Identities = 108/290 (37%), Positives = 160/290 (54%), Gaps = 15/290 (5%)
Query: 101 DAEFLTYVLSYSKRIXXXXXXXXXXXXXIPDFRSANGLFTTLKSSSPNVKSGKDLFDFNH 160
D L + +KRI IPDFRS+ GLF++L++ SGK+LFD
Sbjct: 46 DLSPLVSAIRKAKRIVVVTGAGISCDAGIPDFRSSEGLFSSLRAEYKLNCSGKELFD-GS 104
Query: 161 VYXXXXXXXXXXXXXXKLHSLSCTSKPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQT 220
VY KLH LS ++PT +H F++QL +++++ R+Y+QNID LET+ +
Sbjct: 105 VYRDLKSVNIFHAMIRKLHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFLETRLEG 164
Query: 221 TSA----NESPKNPQVVQLHGSIHHMSCMKCRKKYDMDPSMFKTDEDAETGEIVPQCPEC 276
+S P + LHG++ +SC +C +P +F + V CP+C
Sbjct: 165 LQTCIPLPQSAPWPTTIPLHGTLEVVSCTRCSFLKKFNPDIFDRNG-------VTVCPDC 217
Query: 277 KEFESVRSVCGKRLQGVGRLKPSVVLYNEYHPEGDIISEMMNKDLKSNPDALLIVGTSLK 336
K VR + GKR G L+P +VLYNE HP+ + I + ++DLKS PD L++ GTS K
Sbjct: 218 KTENEVRRIAGKRSVIEGCLRPRIVLYNEIHPDSESIGSVCSQDLKSRPDCLIVAGTSCK 277
Query: 337 IPGVRQMVKQFATKVRAKKGFIIWVNNELPPPNIKTLLNRCDLVVLGDCQ 386
IPGV++++K+ + V +KG +IW+N + P K LN CDLVV GD Q
Sbjct: 278 IPGVKRIIKEMSNCVHKQKGNVIWLNYDEP---TKDFLNLCDLVVQGDLQ 324
>YOR025w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 447
Score = 161 bits (408), Expect = 1e-39
Identities = 108/306 (35%), Positives = 160/306 (51%), Gaps = 22/306 (7%)
Query: 105 LTYVLSYSKRIXXXXXXXXXXXXXIPDFRSANGLFTTLKSSSP---NVKSGKDLFDFNHV 161
+T LS S+RI IPDFRS++GL+ +K ++KSG+++FD + +
Sbjct: 45 VTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQYWSIKSGREMFDIS-L 103
Query: 162 YXXXXXXXXXXXXXXKLHSLSCTSKPTAYHSFINQLCEKNQVKRIYSQNIDGLET----- 216
+ +L+S +KPT H FI L ++N++ R Y+QNIDGLE
Sbjct: 104 FRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLT 163
Query: 217 ----KFQTTSANESPKNPQVVQLHGSIHHMSCMKCRKKYDMDPSMFKTDEDAETGEIVPQ 272
K TS + KN VVQLHG + +SC KC + + P GE+ P
Sbjct: 164 LSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTF---PWSRYWSRCLRRGEL-PL 219
Query: 273 CPECKEFESVRSVCGKRLQG--VGRLKPSVVLYNEYHPEGDIISEMMNKDL-KSNPDALL 329
CP+C+ + R GKR G VG L+P++VLY E HP +II++ +N D+ K NPD L+
Sbjct: 220 CPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLI 279
Query: 330 IVGTSLKIPGVRQMVKQFATKVRAKKGFIIWVNNELPPPNIKTLLNRCDLVVLGDCQNLP 389
I+GTSLK+ GV+Q+VK+ + K+ + G II VN P + D + DC N
Sbjct: 280 IMGTSLKVDGVKQLVKKLSKKIHDRGGLIILVNK--TPIGESSWHGIIDYQIHSDCDNWV 337
Query: 390 VLMEQE 395
+E +
Sbjct: 338 TFLESQ 343
>ECU03g0460 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 425
Score = 103 bits (258), Expect = 3e-22
Identities = 80/273 (29%), Positives = 130/273 (47%), Gaps = 16/273 (5%)
Query: 113 KRIXXXXXXXXXXXXXIPDFRSANGLFTTLKSSSPNVKSGKDLFDFNHVYXXXXXXXXXX 172
+R+ IPDFRS +GLF +K SG DLF ++ +
Sbjct: 86 RRVVVITGAGISVSSGIPDFRSKSGLFNDIKKDLG--VSGNDLFTYS-LSMSKELRKGYL 142
Query: 173 XXXXKLHSLSCTSKPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQV 232
KL ++ ++P+A H F++ + ++ RIY+QNIDGLE K + + ++ ++
Sbjct: 143 RYISKLKNMVDKAQPSATHEFLSLYSDISRRFRIYTQNIDGLEEKAGLAATKD--RSTRL 200
Query: 233 VQLHGSIHHMSCMKCRKKYDMDPSMFKTDEDAETGEIVPQCPECKEFESVRSVCGKRLQG 292
V LHG++ + C+ C K + + + D EIV C C R R +
Sbjct: 201 VYLHGNMKSLGCLYCGYKIEFGDA--ERDAYGRGEEIV--CAGCVRRNEKRG-RDVRKRP 255
Query: 293 VGRLKPSVVLYNEYHPEGDIISEMMNKDLKSNPDALLIVGTSLKIPGVRQMVKQFATKVR 352
VG +++ YN+ HP+ IS+M D + D +++GTSLK+ GVR++VK F ++
Sbjct: 256 VGVFHTTIIHYNQSHPDSSFISKMAEHD--NTCDLFIVMGTSLKVFGVRRLVKYFC-RLN 312
Query: 353 AKKGFIIWVNNELPPPNIKTLLNRCDLVVLGDC 385
+ +G I VN + P L D GDC
Sbjct: 313 STRGRRILVNLDRPSKEFGELF---DFFWNGDC 342
>7298007 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 823
Score = 75.1 bits (183), Expect = 2e-13
Identities = 66/231 (28%), Positives = 98/231 (41%), Gaps = 24/231 (10%)
Query: 112 SKRIXXXXXXXXXXXXXIPDFRSANGLFTTLKSSSPNVKSGKDLFDFNHVYXXXXXXXXX 171
S++I IPDFRS NG++ L P++ + +FD N+
Sbjct: 221 SQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKF 280
Query: 172 XXXXXKLHSLSCTSKPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQ 231
+P+ H FI L K ++ R Y+QNID LE +
Sbjct: 281 AREIYPGEF-----QPSPCHRFIKMLETKGKLLRNYTQNIDTLE---------RVAGIQR 326
Query: 232 VVQLHGSIHHMSCMKCRKKYDMDPSMFKTDEDAETGEIVPQCPECKEFESVRSVCG---- 287
V++ HGS SC KCR K + D + D A+ + PQC KE SV
Sbjct: 327 VIECHGSFSTASCTKCRFKCNAD--ALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEE 384
Query: 288 -KRLQGVGRLKPSVVLYNEYHPEGDIISEMMNKDLKSNPDALLIVGTSLKI 337
++L G +KP +V + E P D +M D K D L+++G+SLK+
Sbjct: 385 LRQLVENGIMKPDIVFFGEGLP--DEYHTVMATD-KDVCDLLIVIGSSLKV 432
>Hs7657575 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 747
Score = 71.2 bits (173), Expect = 2e-12
Identities = 71/284 (25%), Positives = 115/284 (40%), Gaps = 42/284 (14%)
Query: 108 VLSYSKRIXXXXXXXXXXXXXIPDFRSANGLFTTLKSSSPNVKSGKDLFDFNHVYXXXXX 167
+L K+I IPDFRS +G++ L P++ + +FD +
Sbjct: 249 LLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRP 308
Query: 168 XXXXXXXXXKLHSLSCTSKPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESP 227
+P+ H FI ++ ++ R Y+QNID LE +
Sbjct: 309 FFKFAKEIYPGQF-----QPSLCHKFIALSDKEGKLLRNYTQNIDTLE---------QVA 354
Query: 228 KNPQVVQLHGSIHHMSCMKCRKKYDMDPSMFKTDEDAETGEIVPQCPECKEFESVRSVCG 287
+++Q HGS SC+ C KY +D + D ++VP+CP C E
Sbjct: 355 GIQRIIQCHGSFATASCLIC--KYKVDCEAVRGD---IFNQVVPRCPRCPADEP------ 403
Query: 288 KRLQGVGRLKPSVVLYNEYHPEGDIISEMMNKDLKSNPDALLIVGTSLKIPGVRQMVKQF 347
+ +KP +V + E PE M D K D L+++G+SLK+ V +
Sbjct: 404 -----LAIMKPEIVFFGENLPEQ--FHRAMKYD-KDEVDLLIVIGSSLKVRPVALIPSSI 455
Query: 348 ATKVRAKKGFIIWVNNELPPPNIK---TLLNRCDLVVLGDCQNL 388
+V I +N E P P++ LL CD+++ C L
Sbjct: 456 PHEVPQ-----ILINRE-PLPHLHFDVELLGDCDVIINELCHRL 493
>CE06302 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 607
Score = 63.2 bits (152), Expect = 7e-10
Identities = 67/262 (25%), Positives = 109/262 (41%), Gaps = 45/262 (17%)
Query: 129 IPDFRSANGLFTTLKSSSPNVKSGKDLFDFNHVYXXXXXXXXXXXXXXKLHSLSCTSKPT 188
IPDFRS +G++ L+S P++ +FD + + P+
Sbjct: 162 IPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFPGQFV-----PS 216
Query: 189 AYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQVVQLHGSIHHMSCMKCR 248
H FI +L ++ R Y+QNID LE +VV+ HGS +C +C
Sbjct: 217 VSHRFIKELETSGRLLRNYTQNIDTLE---------HQTGIKRVVECHGSFSKCTCTRCG 267
Query: 249 KKYDMDPSMFKTDEDAETGEIVPQCPECKEFESVRSVCGKRLQGVGRLKPSVVLYNEYHP 308
+KYD + +E ++R KR +GV +KP++V + E
Sbjct: 268 QKYDGNEIR-------------------EEVLAMRVAHCKRCEGV--IKPNIVFFGE--D 304
Query: 309 EGDIISEMMNKDLKSNPDALLIVGTSLKIPGVRQMVKQFATKVRAKKGFIIWVNNE-LPP 367
G + + +D K D ++++G+SLK+ V + V I +N E LP
Sbjct: 305 LGREFHQHVTED-KHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQ-----ILINRESLPH 358
Query: 368 PNIK-TLLNRCDLVVLGDCQNL 388
N LL CD ++ C +L
Sbjct: 359 YNADIELLGNCDDIIRDICFSL 380
>YOL068c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 503
Score = 60.1 bits (144), Expect = 6e-09
Identities = 62/263 (23%), Positives = 109/263 (40%), Gaps = 36/263 (13%)
Query: 103 EFLTYVLSYSKRIXXXXXXXXXXXXXIPDFRSANGLFTTLKSSSPNVKSGKDLFDFNHVY 162
+ T L +K+I IPDFRS+ G ++ ++ ++ +D+F+ +
Sbjct: 191 DHFTATLRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLG--LEDPQDVFNLDIFL 248
Query: 163 XXXXXXXXXXXXXXKLHSLSCTSKPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTS 222
++ + HSFI L +K ++ R Y+QNID LE +
Sbjct: 249 QDPSVFYNIAHMVLPPENMY-----SPLHSFIKMLQDKGKLLRNYTQNIDNLE-----SY 298
Query: 223 ANESPKNPQVVQLHGSIHHMSCMKCRKKYDMDPSMFKTDEDAETGEIVPQCPECKE---- 278
A P ++VQ HGS SC+ C + + +F+ + E +P CP C +
Sbjct: 299 AGIDP--DKLVQCHGSFATASCVTCHWQIPGE-KIFENIRNLE----LPLCPYCYQKRKQ 351
Query: 279 ----------FESVRSVCGKRLQGVGRLKPSVVLYNEYHPEGDIISEMMNKDLKSNPDAL 328
++ + L+ G LKP + + E P + + KD+ D L
Sbjct: 352 YFPMSNGNNTVQTNINFNSPILKSYGVLKPDMTFFGEALPSR--FHKTIRKDI-LECDLL 408
Query: 329 LIVGTSLKIPGVRQMVKQFATKV 351
+ +GTSLK+ V ++V + V
Sbjct: 409 ICIGTSLKVAPVSEIVNMVPSHV 431
>SPBC16D10.07c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 471
Score = 59.7 bits (143), Expect = 7e-09
Identities = 63/260 (24%), Positives = 111/260 (42%), Gaps = 39/260 (15%)
Query: 103 EFLTYVLSYSKRIXXXXXXXXXXXXXIPDFRSANGLFTTLKSSSPNVKSGKDLFDFNHVY 162
E + +L +K + I DFRS NG + L + + ++FD H +
Sbjct: 143 EDVVNLLKKAKNVVVLVGAGISTSLGILDFRSDNGFYARL--ARHGLSEPSEMFDI-HTF 199
Query: 163 XXXXXXXXXXXXXXKLHSLSCTSKPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTS 222
L T+ + H+FI L +KN++ +++QNID LE K T
Sbjct: 200 RENPEIFYTFARDL----LPETNHYSPSHAFIRLLEKKNKLSTLFTQNIDNLEKK---TG 252
Query: 223 ANESPKNPQVVQLHGSIHHMSCMKCRKKYDMDPSMFKTDEDAETGEIVPQCPEC-KEFES 281
+++ +++Q HGS +C+KC+ K D + ED + V C EC K
Sbjct: 253 LSDN----KIIQCHGSFATATCIKCKHKVDGS----ELYEDIRN-QRVSYCNECGKPPLK 303
Query: 282 VRSVCGKR-----------------LQGVGRLKPSVVLYNEYHPEGDIISEMMNKDLKSN 324
+R V + L G +KP + + E P+ +++ + +L+
Sbjct: 304 LRRVGQNKKEKHYFSDGDSESSEDDLAQPGIMKPDITFFGEALPDS-FFNKVGSGELEET 362
Query: 325 PDALLIVGTSLKIPGVRQMV 344
D L+ +GTSLK+ V +++
Sbjct: 363 -DLLICIGTSLKVAPVSELI 381
>YDL042c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 562
Score = 59.3 bits (142), Expect = 1e-08
Identities = 86/392 (21%), Positives = 147/392 (36%), Gaps = 89/392 (22%)
Query: 35 IKPRKLINDLXXXXXXXXXXXXLCDSPTTRSLPQTTRKPR--LKYRPELDTVFPLDNYVE 92
I ++ + DL L T R + R L R L F +D++++
Sbjct: 190 INSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSNFFTIDHFIQ 249
Query: 93 GSAKSSSKDAEFLTYVLSYSKRIXXXXXXXXXXXXXIPDFRSANGLFTTLKSSSPNVKSG 152
L +++I IPDFRS+ G ++ +K +
Sbjct: 250 K---------------LHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLG--LDDP 292
Query: 153 KDLFDFN---HVYXXXXXXXXXXXXXXKLHSLSCTSKPTAYHSFINQLCEKNQVKRIYSQ 209
+D+F++N H K++S HSFI L K ++ R Y+Q
Sbjct: 293 QDVFNYNIFMHDPSVFYNIANMVLPPEKIYS--------PLHSFIKMLQMKGKLLRNYTQ 344
Query: 210 NIDGLETKFQTTSANESPKNPQVVQLHGSIHHMSCMKCRKKYDMDPSMFKTDEDAETGEI 269
NID LE+ ++ ++VQ HGS +C+ C + +F + E
Sbjct: 345 NIDNLESYAGIST-------DKLVQCHGSFATATCVTCHWNLPGE-RIFNKIRNLE---- 392
Query: 270 VPQCPEC----KEF--ESVRSVCGKR-------------LQGVGRLKPSVVLYNEYHPEG 310
+P CP C +E+ E + G L G LKP + + E P
Sbjct: 393 LPLCPYCYKKRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALP-- 450
Query: 311 DIISEMMNKDLKSNPDALLIVGTSLKIPGVRQMVKQFATKVRAKKGFIIWVNNELPPPNI 370
+ + + +D+ D L+ +GTSLK+ V ++V N +P
Sbjct: 451 NKFHKSIREDI-LECDLLICIGTSLKVAPVSEIV------------------NMVPSHVP 491
Query: 371 KTLLNR-------CDLVVLGDCQNLPVLMEQE 395
+ L+NR DL +LG C ++ ++ Q+
Sbjct: 492 QVLINRDPVKHAEFDLSLLGYCDDIAAMVAQK 523
>SPCC132.02 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 332
Score = 56.6 bits (135), Expect = 6e-08
Identities = 68/277 (24%), Positives = 110/277 (39%), Gaps = 49/277 (17%)
Query: 113 KRIXXXXXXXXXXXXXIPDFRSAN-GLFTTLKSSSPNVKSGKDLFDFNHVYXXXXXXXXX 171
K+I IPDFRS G++ L+ N+ + +FD ++
Sbjct: 28 KKICVMVGAGISTAAGIPDFRSPETGIYNNLQRF--NLPYAEAVFDLSYFRKNPRPFYEL 85
Query: 172 XXXXXKLHSLSCTS-KPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNP 230
H L +PT H FI L +K +++ Y+QNID LE +
Sbjct: 86 A------HELMPEKYRPTYTHYFIRLLHDKRLLQKCYTQNIDTLERL-------AGVPDK 132
Query: 231 QVVQLHGSIHHMSCMKCRKKYDMDPSMFKTDEDAETGEIVPQCPECKEFESVRSVCGKRL 290
+++ HGS + C++C Y+M + + + VP+C CK
Sbjct: 133 ALIEAHGSFQYSRCIEC---YEMAETEYV--RACIMQKQVPKCNSCK------------- 174
Query: 291 QGVGRLKPSVVLYNEYHPEGDIISEMMNKDLKSNPDALLIVGTSLKIPGVRQMVKQFATK 350
G +KP +V Y E P E M KD K D L++GTSL + + + K
Sbjct: 175 ---GLIKPMIVFYGEGLPMR--FFEHMEKDTKV-CDMALVIGTSLLVHPFADLPEIVPNK 228
Query: 351 VRAKKGFIIWVNNELPPPNIKTLLNRCDLVVLGDCQN 387
+ + +N E P + D+++LGDC +
Sbjct: 229 CQR-----VLINRE---PAGDFGERKKDIMILGDCDS 257
>Hs6912660 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 399
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/201 (26%), Positives = 91/201 (44%), Gaps = 42/201 (20%)
Query: 186 KPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQVVQLHGSIHHMSCM 245
KP H F+ L +K + R+Y+QNIDGLE ++ ++V+ HG+ +C
Sbjct: 205 KPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPAS-------KLVEAHGTFASATCT 257
Query: 246 KCRKKYDMDPSMFKTDEDAETGEIVPQCPECKEFESVRSVCGKRLQGVGRLKPSVVLYNE 305
C++ + + + D A+ VP+CP C G +KP +V + E
Sbjct: 258 VCQRPFPGED--IRADVMADR---VPRCPVC----------------TGVVKPDIVFFGE 296
Query: 306 YHPEGDIISEMMNKDLKSNPDALLIVGTSLKIPGVRQMVKQFATKVRAKKGFI--IWVNN 363
P+ ++ + D D LLI+GTSL+ V+ FA+ A + + + +N
Sbjct: 297 PLPQRFLLHVV---DFPM-ADLLLILGTSLE-------VEPFASLTEAVRSSVPRLLINR 345
Query: 364 ELPPPNIKTLLNRCDLVVLGD 384
+L P +R D+ LGD
Sbjct: 346 DLVGPLAWHPRSR-DVAQLGD 365
>YPL015c [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 357
Score = 53.5 bits (127), Expect = 5e-07
Identities = 43/179 (24%), Positives = 75/179 (41%), Gaps = 39/179 (21%)
Query: 186 KPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQVVQLHGSIHHMSCM 245
+P+ +H + +K+ +KR+Y+QNID LE + K+ +++ HGS H C+
Sbjct: 92 RPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQ-------AGVKDDLIIEAHGSFAHCHCI 144
Query: 246 KCRKKYDMDPSMFKTDEDAETGEIVPQCPECKEFESVRSVCGKRLQGVGRLKPSVVLYNE 305
C K Y P +FK+ + +C C E +KP++V + E
Sbjct: 145 GCGKVY--PPQVFKSKLAEHPIKDFVKCDVCGEL----------------VKPAIVFFGE 186
Query: 306 YHPEGDIISEMMNKDLK------------SNPDALLIVGTSLKIPGVRQMVKQFATKVR 352
P D SE D + +++VGTSL + + ++ KV+
Sbjct: 187 DLP--DSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVK 243
>Hs13775602 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 352
Score = 51.6 bits (122), Expect = 2e-06
Identities = 41/161 (25%), Positives = 70/161 (43%), Gaps = 29/161 (18%)
Query: 186 KPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQVVQLHGSIHHMSCM 245
KPT H F+ L +K + R Y+QNID LE + +V+ HG+ + C+
Sbjct: 107 KPTICHYFMRLLKDKGLLLRCYTQNIDTLE-------RIAGLEQEDLVEAHGTFYTSHCV 159
Query: 246 KCRKKYDMDPSMFKTDEDAETGEIVPQCPECKEFESVRSVCGKRLQGVGRLKPSVVLYNE 305
+++ S K + E+ P+C +C+ +KP +V + E
Sbjct: 160 SASCRHEYPLSWMK---EKIFSEVTPKCEDCQSL----------------VKPDIVFFGE 200
Query: 306 YHPEGDIISEMMNKDLKSNPDALLIVGTSLKIPGVRQMVKQ 346
P S M + LK D LL++GTSL++ ++ +
Sbjct: 201 SLP-ARFFSCMQSDFLK--VDLLLVMGTSLQVQPFASLISK 238
>Hs13775600 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 389
Score = 51.6 bits (122), Expect = 2e-06
Identities = 41/161 (25%), Positives = 70/161 (43%), Gaps = 29/161 (18%)
Query: 186 KPTAYHSFINQLCEKNQVKRIYSQNIDGLETKFQTTSANESPKNPQVVQLHGSIHHMSCM 245
KPT H F+ L +K + R Y+QNID LE + +V+ HG+ + C+
Sbjct: 144 KPTICHYFMRLLKDKGLLLRCYTQNIDTLE-------RIAGLEQEDLVEAHGTFYTSHCV 196
Query: 246 KCRKKYDMDPSMFKTDEDAETGEIVPQCPECKEFESVRSVCGKRLQGVGRLKPSVVLYNE 305
+++ S K + E+ P+C +C+ +KP +V + E
Sbjct: 197 SASCRHEYPLSWMK---EKIFSEVTPKCEDCQSL----------------VKPDIVFFGE 237
Query: 306 YHPEGDIISEMMNKDLKSNPDALLIVGTSLKIPGVRQMVKQ 346
P S M + LK D LL++GTSL++ ++ +
Sbjct: 238 SLP-ARFFSCMQSDFLK--VDLLLVMGTSLQVQPFASLISK 275
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,062,400
Number of Sequences: 60738
Number of extensions: 900057
Number of successful extensions: 2509
Number of sequences better than 1.0e-05: 15
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2469
Number of HSP's gapped (non-prelim): 18
length of query: 399
length of database: 30,389,216
effective HSP length: 109
effective length of query: 290
effective length of database: 23,768,774
effective search space: 6892944460
effective search space used: 6892944460
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)