ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV4605 check: MH TU KOG0906 Intracellular trafficking, secretion, and vesicular transport Phosphatidylinositol 3-kinase VPS34, involved in signal transduction
r_klactIV4605 check: MH TU KOG0906 Signal transduction mechanisms Phosphatidylinositol 3-kinase VPS34, involved in signal transduction
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV4605 1573694 1571109 -862
(862 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR240w [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 1014 0.0
SPAC458.05 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invo... 481 e-135
Hs18589256 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invo... 470 e-132
Hs4505801 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invol... 439 e-123
At1g60490 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invol... 426 e-118
CE24759 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 340 4e-93
CE24760 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 327 5e-89
7291607 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 284 4e-76
Hs19923289 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic s... 236 9e-62
Hs15451926 [T] KOG0905 Phosphoinositide 3-kinase 221 5e-57
Hs4505799 [T] KOG0905 Phosphoinositide 3-kinase 217 7e-56
HsM4505803 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic s... 214 3e-55
Hs21237725 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic s... 214 3e-55
Hs5453892 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic su... 213 1e-54
7300643 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subu... 205 3e-52
Hs5453894 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic su... 203 8e-52
Hs4758924 [T] KOG0905 Phosphoinositide 3-kinase 194 5e-49
CE05832 [T] KOG0905 Phosphoinositide 3-kinase 182 1e-45
7294673 [T] KOG0905 Phosphoinositide 3-kinase 174 5e-43
CE23506 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subu... 156 1e-37
ECU11g0450 [T] KOG0902 Phosphatidylinositol 4-kinase 120 7e-27
YLR305c [T] KOG0902 Phosphatidylinositol 4-kinase 116 2e-25
SPBC577.06c [T] KOG0902 Phosphatidylinositol 4-kinase 106 2e-22
At1g49340 [T] KOG0902 Phosphatidylinositol 4-kinase 105 3e-22
Hs4505809 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in... 101 4e-21
CE23035 [T] KOG0902 Phosphatidylinositol 4-kinase 101 6e-21
7290340 [T] KOG0902 Phosphatidylinositol 4-kinase 99 4e-20
YNL267w [TU] KOG0903 Phosphatidylinositol 4-kinase involved in i... 98 5e-20
At1g51040 [T] KOG0902 Phosphatidylinositol 4-kinase 97 1e-19
At5g64070 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in... 96 3e-19
At5g09350 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in... 94 1e-18
ECU10g0590 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invo... 89 4e-17
Hs4505807 [T] KOG0902 Phosphatidylinositol 4-kinase 87 1e-16
Hs17105400 [T] KOG0902 Phosphatidylinositol 4-kinase 87 1e-16
Hs4826730 [L] KOG0891 DNA-dependent protein kinase 77 9e-14
Hs22068531 [T] KOG0902 Phosphatidylinositol 4-kinase 77 9e-14
CE04513 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in i... 77 1e-13
At1g50030 [L] KOG0891 DNA-dependent protein kinase 76 2e-13
SPAC22E12.16c [TU] KOG0903 Phosphatidylinositol 4-kinase involve... 75 6e-13
ECU03g1100 [TU] KOG0903 Phosphatidylinositol 4-kinase involved i... 74 1e-12
CE28813 [L] KOG0891 DNA-dependent protein kinase 72 3e-12
CE07705 [L] KOG0891 DNA-dependent protein kinase 72 3e-12
7297995 [L] KOG0891 DNA-dependent protein kinase 68 5e-11
CE28250 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 68 7e-11
CE25103 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 68 7e-11
YBR136w [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 66 3e-10
YJR066w [L] KOG0891 DNA-dependent protein kinase 64 1e-09
YKL203c [L] KOG0891 DNA-dependent protein kinase 60 2e-08
7291958 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in i... 59 2e-08
Hs20533633 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic s... 51 9e-06
>YLR240w [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 875
Score = 1014 bits (2623), Expect = 0.0
Identities = 532/878 (60%), Positives = 644/878 (72%), Gaps = 21/878 (2%)
Query: 1 MALNSVTFFVSHECDACLTVKIINLEGSSALLKQSEKYTEPDLSKRASNFIPNSDMFVSL 60
M+LN++TF VS + D L VKI +LEG LLK S+K P+L SN P+SD+ VSL
Sbjct: 1 MSLNNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSL 60
Query: 61 QVFDGETGRNLTIPVYTKYVPFKNSRVWDQWLTLPIKINQLDMTSTLLIELWEYNGDTRS 120
QVFD E RNLT+P+YT Y+PF+NSR WD WLTLPI+I QL +S L I LWEYNG +
Sbjct: 61 QVFDKERNRNLTLPIYTPYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQI 120
Query: 121 IFAKLETQIFNSHDYSLKRGREVFKFTKDNEKRALPMKD-QNIALINDYHTGELKTSQWL 179
F LET IFN D +LKRG E KF D + D ++ +N Y GE WL
Sbjct: 121 PFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLNKYFQGEFTRLPWL 180
Query: 180 DNSVISALEEQVKGEKLPLGTFKLTIQHKITQVPIVYTASEVSNAQVNIPTFHNLE--RN 237
D IS L +Q + P GTF L ++ + ++P+V+ E+ N Q+NIPT N
Sbjct: 181 DEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTQMNIPTLKNNPGLST 240
Query: 238 EIQENGNKSENEVKISLGKSHESTLFFYDPDQYNTDLIEEKFRRLERSSRETDTEKYIKP 297
+++E N+++ ++KISLG + STL FYDPDQ N D IEEK+RRLER+S+ + +K +KP
Sbjct: 241 DLREP-NRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERASKNANLDKQVKP 299
Query: 298 DAKKRDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEV 357
D KKRD LN II PPGTKLT HEKG IWKYRYYL NNKKALTKLLQSTNL EESE EV
Sbjct: 300 DIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEV 359
Query: 358 LDLMDIWAEIDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFECT 417
L+LMD WAEID+DD +ELLG + N+SVRSYAVNRL+KASD ELELYLLQLV++VCFE
Sbjct: 360 LELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENL 419
Query: 418 STLSDKSNSEFTIVNIENSNNDQNYSGDII-----DASQFLANSFDKNS---------VM 463
ST SDKSNSEFTIV+ +S Q SGD + A+Q L S S ++
Sbjct: 420 STFSDKSNSEFTIVDAVSS---QKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIV 476
Query: 464 ISPLAEFLIRRAVKNFRLGNFFYWYLRSESERNTFLVHILESFKSRLPEHSKKTIDDQIL 523
ISPLAEFLIRRA+ N RLG+FFYWYL+SESE +L IL SF SRL + S+ ++DQ+
Sbjct: 477 ISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVR 536
Query: 524 LVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITLPLDPDVIAVDVIPSS 583
L+++LR+ CE IK+ K+TT KK E+L+HL+ +++R L K + I LPLDPDV+ DV P +
Sbjct: 537 LINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPET 596
Query: 584 CKVFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLT 643
KVFKSSLSPLKITF T Q Y LMFKVGDDL QDQLVVQII LM++LLKNENVDLKLT
Sbjct: 597 SKVFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLT 656
Query: 644 PYNILATGKNEGAIGFIPNETMSSILSVHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKS 703
PY ILATG EGAI FIPN+T++SILS +HGIL YL+ +YP + GV+ WV+DNFVKS
Sbjct: 657 PYKILATGPQEGAIEFIPNDTLASILSKYHGILGYLKLHYPDENATLGVQGWVLDNFVKS 716
Query: 704 CAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXXXXXXXXXXQIIEAFG 763
CAGYCVITYILGVGDRHLDNLL+ PDG FFHADFGYILG D QIIEAFG
Sbjct: 717 CAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPPQIIEAFG 776
Query: 764 GTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAF 823
G +S+NYDKFRSYCFVAYSILRRNAGLI+NLFELMKTS+IP+I++DP GA+L+V E+F
Sbjct: 777 GAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNL 836
Query: 824 DLSEEDATIHFQNLITTSVNALIPLVIDHLHNLAQYWR 861
++SEEDAT+HFQNLI SVNAL+P+VIDHLHNLAQYWR
Sbjct: 837 NMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWR 874
>SPAC458.05 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 801
Score = 481 bits (1239), Expect = e-135
Identities = 297/837 (35%), Positives = 450/837 (53%), Gaps = 107/837 (12%)
Query: 59 SLQVFDGETGRNLTIPVYTKYVPFKN------SRV-WDQWLTLPIKINQLDMTSTLLIEL 111
++Q+F G +L + +P K+ S++ +WL + +++L + + ++
Sbjct: 37 TIQLFSGNESGSLMQKCFVSKIPNKSLLPTELSKISTHEWLDFGVTVSELSLNAKFVVSA 96
Query: 112 WEYNGDTRSIFAKLETQIFNSHDYS-----------LKRGREVFKFTKDN-EKRALPMKD 159
W+ + + ++ + + D + L+ +E+ K++ + E + +
Sbjct: 97 WKPSFNDEEVYEFVGCTTYRLFDENNLLRQGLQKIPLQTSKEIKKYSPTSLELEQVKEIN 156
Query: 160 QNIALINDYHTGELKTSQWLDNSVISALEEQVKGEKLPLGTFKLTIQHKITQVPIVYTAS 219
+ L+ G++ + WLD+ +++ + + + L T +PI+Y
Sbjct: 157 RLDGLLLKLQLGDVPSVNWLDDISFGKIKD-FRSKHMSLVT-----------IPILY--- 201
Query: 220 EVSNAQVNIPTFHNLERNEIQENGNKSENEVKISLGKSHESTLFFYDPDQYNTDLIEEKF 279
+ Q + P + KSEN V S S + L P E K
Sbjct: 202 -LDFLQFSFPVVFQ------RSYYPKSENRVYYS---SFDLELNLDSP-------AELKH 244
Query: 280 RRLERSSRETDTEKYIKPDAKKRDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKAL 339
RRL RS R +K +KP++K R L +I++ PP +L+ EK LIWK+R+YL+ NKKA+
Sbjct: 245 RRLVRSQRNGPLDKDLKPNSKIRKELESILSYPPSEELSLEEKDLIWKFRFYLTRNKKAM 304
Query: 340 TKLLQSTNLSEESEIKEVLDLMDIWAEIDLDDTMELLGPQYTNISVRSYAVNRLRKASDN 399
TK L+S ++ SE+ + L L+D W EID+DD +ELL P + + VR+YAV+RL AS+
Sbjct: 305 TKFLKSVVWTDSSEVNQALSLLDSWTEIDIDDALELLSPSFVHPKVRAYAVSRLETASNE 364
Query: 400 ELELYLLQLVQSVCFECTSTLSDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDK 459
EL LYLLQLVQ++ Y I +F
Sbjct: 365 ELLLYLLQLVQAL----------------------------RYDNPISSDERFQP----- 391
Query: 460 NSVMISPLAEFLIRRAVKNFRLGNFFYWYLRSESERNT-----------FLVHILESFKS 508
SPLA FL+ RA+ + +GN YWYL E E F + +S +
Sbjct: 392 -----SPLALFLVNRAISSPSIGNDLYWYLVVEIEDEPVSKLFSSVMFLFQKELSKSVEG 446
Query: 509 RLPEHSKKTIDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITL 568
RL ++T+ Q V+ L + + ++ + T +KK E L L+ L A+ L
Sbjct: 447 RL---IRETLSAQAKFVEKLLRISKSVQSFRGTRLKKIEYLKVLLEDHKYHLLDFHALPL 503
Query: 569 PLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKL 628
PLDP V V +IP +C VFKS++ PL++ F +G Y ++FK GDDL QDQLV+QI+ L
Sbjct: 504 PLDPSVNIVGIIPDACTVFKSTMQPLRLLFKCQDGSKYPIIFKNGDDLRQDQLVIQILTL 563
Query: 629 MDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSILSVHHG-ILKYLQQNYPSQA 687
MD+LLK E +DL L PY ILATG GA+ F+P++T+++IL+ +HG +L YL++N P
Sbjct: 564 MDKLLKKEKLDLHLKPYRILATGPTHGAVQFVPSKTLATILAEYHGSVLAYLRENNPDDG 623
Query: 688 EID---GVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYD 744
G++P MDN+V+SCAGYCVITY+LGVGDRHLDNLLI DG FFHADFGYILG D
Sbjct: 624 LNSANYGIDPVAMDNYVRSCAGYCVITYLLGVGDRHLDNLLITKDGHFFHADFGYILGRD 683
Query: 745 XXXXXXXXXXXXQIIEAFGGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIP 804
+++E GG +S Y +F+SYC+ ++ LR+++ LI+NLF LM ++IP
Sbjct: 684 PKLFSPAMKLSKEMVEGMGGYNSPFYQQFKSYCYTTFTALRKSSNLILNLFSLMVDANIP 743
Query: 805 NIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNLITTSVNALIPLVIDHLHNLAQYWR 861
+IK D E V KV E+F +SE DA +F+ LI SV+AL P +ID +HNLAQY R
Sbjct: 744 DIKFDKEKVVYKVKERFCLQMSESDAIKYFEQLINDSVSALFPQIIDRMHNLAQYMR 800
>Hs18589256 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 887
Score = 470 bits (1209), Expect = e-132
Identities = 308/913 (33%), Positives = 459/913 (49%), Gaps = 92/913 (10%)
Query: 8 FFVSHECDACLTV--KIINLEGSSALLKQSEKYTEPDLSKRASNFIPNSDMFVSLQVFDG 65
F + CD + V KI +LEG +P L SD++V+ QVF
Sbjct: 7 FHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVF-- 64
Query: 66 ETGRNLTIPVYTKYVPFKNSRVWDQWLTLPIKINQLDMTSTLLIELWE---------YNG 116
G+ L +PV T Y F W++WL LP+K L + + + +W+ G
Sbjct: 65 AEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGG 124
Query: 117 DTRSIFAKLETQIFNSHDYSLKRGREV--FKFTKDNEKRALPMKDQNIA----LINDYHT 170
T S+F K HD + E + TK + + + + ++ L +
Sbjct: 125 TTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQ 184
Query: 171 GELKTSQWLDNSVISALEEQVKGEKLPLGTFKLTIQHKIT-----QVPIVYTASEVSNAQ 225
G + WLD +E + EK L ++ + + IVY + +
Sbjct: 185 GHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESS 244
Query: 226 VNIPTFHNLERNEIQENGNKSENEVKISLGKSHESTLFFYDPDQYNTDLIEEKFRRLERS 285
+ +F VK+ DP +L+E K +L RS
Sbjct: 245 PILTSF----------------ELVKVP------------DPQMSMENLVESKHHKLARS 276
Query: 286 SRETDTEKYIKPDAKKRDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQS 345
R ++ +KP+A RD LN I++ PP +LT E+ L+WK+RYYL+N +KALTK L+
Sbjct: 277 LRSGPSDHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKC 336
Query: 346 TNLSEESEIKEVLDLMDIWAEIDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELYL 405
N E K+ L+L+ W +D++D++ELL YTN +VR YAV RLR+A D +L +YL
Sbjct: 337 VNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYL 396
Query: 406 LQLVQSVCFECTSTLSD-----KSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKN 460
LQLVQ++ +E + + K +S+ ++ EN +N S + ID+SQ + +
Sbjct: 397 LQLVQALKYENFDDIKNGLEPTKKDSQSSV--SENVSNSGINSAE-IDSSQIITSPLPSV 453
Query: 461 SV---------------MISPLAEFLIRRAVKNFRLGNFFYWYLRSESE----------R 495
S + L FLI RA KN L N+ YWY+ E E
Sbjct: 454 SSPPPASKTKEVPDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKT 513
Query: 496 NTFLVHILESFKSRLPEHSKKT------IDDQILLVDMLRKFCEEIKQSKETTVKKQEIL 549
+ ++++ F L + K + Q VD L + +++ KK E L
Sbjct: 514 HEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERL 573
Query: 550 LHLISSRMR-SLFKNKAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTANGQHYSL 608
L+ + +L + I LPL+P V +IP + +FKS+L P ++ F T +G Y +
Sbjct: 574 QALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPV 633
Query: 609 MFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSI 668
+FK GDDL QDQL++QII LMD+LL+ EN+DLKLTPY +LAT G + FI + ++ +
Sbjct: 634 IFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEV 693
Query: 669 LSVHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQP 728
L I + ++ PS+ +G+ VMD +VKSCAGYCVITYILGVGDRHLDNLL+
Sbjct: 694 LDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTK 753
Query: 729 DGKFFHADFGYILGYDXXXXXXXXXXXXQIIEAFGGTDSANYDKFRSYCFVAYSILRRNA 788
GK FH DFGYILG D +++E GGT S Y +FR C+ A+ LRR +
Sbjct: 754 TGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYS 813
Query: 789 GLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNLITTSVNALIPL 848
LI+NLF LM ++IP+I ++P+ V KV +KF DLS+E+A + Q+LI SV+AL
Sbjct: 814 NLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAA 873
Query: 849 VIDHLHNLAQYWR 861
V++ +H AQYWR
Sbjct: 874 VVEQIHKFAQYWR 886
>Hs4505801 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 887
Score = 439 bits (1129), Expect = e-123
Identities = 299/915 (32%), Positives = 447/915 (48%), Gaps = 96/915 (10%)
Query: 8 FFVSHECDACLTV--KIINLEGSSALLKQSEKYTEPDLSKRASNFIPNSDMFVSLQVFDG 65
F + CD + V KI +LEG + +P L SD++V+ QVF
Sbjct: 7 FHYIYSCDLDINVQLKIGSLEGKREQKSYNAVLEDPMLKFSGLYQETCSDLYVTCQVF-- 64
Query: 66 ETGRNLTIPVYTKYVPFKNSRVWDQWLTLPIKINQLDMTSTLLIELWEY---------NG 116
G+ +PV T Y F W++WL LP+K L + + + +W+ G
Sbjct: 65 AEGKPSALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGG 124
Query: 117 DTRSIFAKLETQIFNSHDYSLKRGREVFKFTKDNE--KRALPMKDQNIA----LINDYHT 170
T S+F K HD + E N + + + + ++ L +
Sbjct: 125 TTVSLFGKYGMSRQGMHDLKVWPNVEADGSEPTNTPGRTSSTLSEDQMSRLAKLTKAHRQ 184
Query: 171 GELKTSQWLDNSVISALE---EQVKGEK---LPLGTFKLTIQHKITQVPIVYTASEVSNA 224
G + WLD +E E VK +G F+ ++ + IVY + +
Sbjct: 185 GHMVKVDWLDRLTFREIEMINESVKRSSNFMYLMGGFRC-VKCDDKEYGIVYYEKDGDES 243
Query: 225 QVNIPTFHNLERNEIQENGNKSENEVKISLGKSHESTLFFYDPDQYNTDLIEEKFRRLER 284
+ +F VK+ DP +L+E K L R
Sbjct: 244 SPILTSFEL----------------VKVP------------DPQMSLENLVESKHHNLPR 275
Query: 285 SSRETDTEKYIKPDAKKRDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQ 344
S R ++ +KP RD L I++ PP T E+ L+W++RYYL+N KALTK+L
Sbjct: 276 SLRSGPSDHDLKPYPSPRDQLKNIVSYPPSKPPTYEEQDLVWEFRYYLTNQDKALTKILT 335
Query: 345 STNLSEESEIKEVLDLMDIWAEIDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELY 404
S K+ L L+ W +D++D++EL+ YTN +VR YAV RLR+A D +L +Y
Sbjct: 336 SVIWDLPQGAKQALALLGKWNPMDVEDSLELISSHYTNPTVRRYAVARLRQADDEDLLMY 395
Query: 405 LLQLVQSVCFECTSTLSD-----KSNSEFTIV-NIENSNNDQNYSGDIIDASQFLANSFD 458
L QLVQ++ +E + + K +S+ ++ N+ NS + ID+SQ + +
Sbjct: 396 LSQLVQALKYENFDDIKNGLEPTKKDSQSSVSGNVSNSG----INSAEIDSSQIITSPLP 451
Query: 459 KNSV---------------MISPLAEFLIRRAVKNFRLGNFFYWYLRSESE--------- 494
S + L FLI RA KN L N+ YWY+ E E
Sbjct: 452 SVSSPPPASKTKEVPDGENLEQDLCTFLISRASKNSTLANYLYWYVIVECEDQDTQQRDP 511
Query: 495 -RNTFLVHILESFKSRLPEHSKKT------IDDQILLVDMLRKFCEEIKQSKETTVKKQE 547
+ ++++ F L + K + Q VD L + +++ KK E
Sbjct: 512 KTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNE 571
Query: 548 ILLHLISSRMR-SLFKNKAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTANGQHY 606
L L+ + +L + I LPL+P V +IP + +FKS+L P ++ F T +G Y
Sbjct: 572 RLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKY 631
Query: 607 SLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMS 666
++FK GDDL QDQL++QII LMD+LL+ EN+DLKLTPY +LAT G + FI + ++
Sbjct: 632 PVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVA 691
Query: 667 SILSVHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLI 726
+L I + ++ PS+ +G+ VMD +VKSCAGYCVITYILGVGDRHLDNL++
Sbjct: 692 EVLDTEGSIQNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLVL 751
Query: 727 QPDGKFFHADFGYILGYDXXXXXXXXXXXXQIIEAFGGTDSANYDKFRSYCFVAYSILRR 786
GK FH DFGYILG D +++E GGT S Y +FR C+ A+ LRR
Sbjct: 752 TKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRR 811
Query: 787 NAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNLITTSVNALI 846
+ LI+NLF LM +IP+I ++P+ V KV +KF DLS+E+A + Q+LI SV+AL
Sbjct: 812 YSNLILNLFSLMVDPNIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALF 871
Query: 847 PLVIDHLHNLAQYWR 861
V++ +H AQYWR
Sbjct: 872 AAVVEQIHKFAQYWR 886
>At1g60490 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 814
Score = 426 bits (1094), Expect = e-118
Identities = 284/892 (31%), Positives = 447/892 (49%), Gaps = 109/892 (12%)
Query: 1 MALNSVTFFVSHECDACLTVKIINLEGSSALLKQSEKYTEPDLSKRASNFIPNSDMFVSL 60
M N FF+S + ++ +T +I L+G+ + K S+ ++ +++
Sbjct: 1 MGANEFRFFLSCDINSPVTFRIEKLDGNLPVKKSSDSGVVSIAEEKKPELYIECALYID- 59
Query: 61 QVFDGETGRNLTIPVYTKYVPFKNSRVWDQWLTLPIKINQLDMTSTLLIELWEYN-GDTR 119
G +P+ T+ W++ +TL K L S L I +W+ + G T
Sbjct: 60 -------GAPFGLPMRTRLKTTGPPYCWNELITLSSKYRDLTAHSQLAITVWDVSCGKTE 112
Query: 120 SIFAKLETQIFNSHDYSLKRGREVFKFTKDNEK-----RALPMK---------DQNIALI 165
+ +FNS +K G++ + + E + P K ++ L+
Sbjct: 113 GLIGGATVLLFNSK-MQMKSGKQKLRLWQGKEADGSFPTSTPGKVPRHERGELERLEKLM 171
Query: 166 NDYHTGELKTSQWLDNSVISALEEQVKGEKLPLGTFKLTIQHKITQVPIVYTASEVSNAQ 225
N Y G++++ WLD ++ +L+ + E G+ L +
Sbjct: 172 NKYERGQIQSIDWLDRLMLKSLDTIKEQESTKHGSSHLFVV------------------- 212
Query: 226 VNIPTFHNLERNEIQENGNKSENEVKISLGKSHESTLFFYDPDQYNTDLIEEKFRRLERS 285
++ +F + R QE+G + + +G ++E +D + T+ E K +L RS
Sbjct: 213 IDFCSFEH--RVVFQESG--ANLFITAPIGSTNEFVTV-WDTELGKTNPSENKQLKLARS 267
Query: 286 SRETDTEKYIKPDAKKRDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQS 345
++ +KP +R + ++ PP L+ E+ L+WK+R+ L + K+ALTK L+
Sbjct: 268 LDRGIIDRDLKPSNIERKSIQRVLKYPPTRTLSGDERQLLWKFRFSLMSEKRALTKFLRC 327
Query: 346 TNLSEESEIKEVLDLMDIWAEIDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELYL 405
S+ E K+ + LM W ID+ D +ELL P + + VR+YAV+ L +A D EL+ YL
Sbjct: 328 VEWSDVQEAKQAIQLMYKWEMIDVCDALELLSPLFESEEVRAYAVSVLERADDEELQCYL 387
Query: 406 LQLVQSVCFECTSTLSDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKNSVMIS 465
LQLVQ++ FE SD+S
Sbjct: 388 LQLVQALRFE----RSDRSC---------------------------------------- 403
Query: 466 PLAEFLIRRAVKNFRLGNFFYWYLRSESERNTFL------VHILESFKSRLPEHSK---- 515
L++FL++RA++N L +F WY+ E + + +LE +LP
Sbjct: 404 -LSQFLVQRALQNIELASFLRWYVAVELHDHVYAKRFYSTYELLEENIIKLPPGVNGEDG 462
Query: 516 ----KTIDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMRSL-FKNKAITLPL 570
+++ Q L L E++ + T KK E L L+ + L + + I PL
Sbjct: 463 YQLWQSLVRQTELTAQLCSITREVRNVRGNTQKKIEKLRQLLGGLLSELTYFEEPIRSPL 522
Query: 571 DPDVIAVDVIPSSCKVFKSSLSPLKITFLTAN-GQHYSLMFKVGDDLIQDQLVVQIIKLM 629
P+V+ ++ +FKS+L PL++TF T G L+FK GDDL QDQLVVQ++ LM
Sbjct: 523 TPNVLIKGIVAGESSLFKSALHPLRLTFRTPEEGGSCKLIFKKGDDLRQDQLVVQMVWLM 582
Query: 630 DQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSILSVHHGILKYLQQNYPSQAEI 689
D+LLK EN+DL LTPY +LATG +EG + FIP+ +++ ILS H I YLQ+ +P +
Sbjct: 583 DRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKFHPDEHAP 642
Query: 690 DGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXXX 749
G+ +D F+KSCAGY VITYILG+GDRHLDNLL+ DG+ FH DF +ILG D
Sbjct: 643 FGITATCLDTFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDFAFILGRDPKPFP 702
Query: 750 XXXXXXXQIIEAFGGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMD 809
+++EA GG +S Y +F+SYC AY+ILR+++ LI+NLF LM S IP+I D
Sbjct: 703 PPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFHLMAGSTIPDIASD 762
Query: 810 PEGAVLKVMEKFAFDLSEEDATIHFQNLITTSVNALIPLVIDHLHNLAQYWR 861
PE +LK+ EKF D+ +E FQ+LI SV+AL P +++ +H AQYWR
Sbjct: 763 PEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRWAQYWR 814
>CE24759 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 901
Score = 340 bits (873), Expect = 4e-93
Identities = 246/837 (29%), Positives = 409/837 (48%), Gaps = 92/837 (10%)
Query: 88 WDQWLTLPIKINQLDMTSTLLIELWEYNGDTRSIFAKLETQIFNSHDYS--LKRGREVFK 145
W++WLTLPI+ + L + L I +WE+ D +I N+ +S L ++
Sbjct: 88 WNEWLTLPIRYSDLSRDAFLHITIWEHEDD----------EIVNNSTFSRRLVAQSKLSM 137
Query: 146 FTKDNEKRALPMKDQ-NIALINDYHTGELKTSQWLD------NSVISALEEQVKGEKLPL 198
F+K ++ + Q N++ D + +T ++ D + + + Q +G +
Sbjct: 138 FSKRGILKSGVIDVQMNVSTTPDPFVKQPETWKYSDAWGDEIDLLFKQVTRQSRGLVEDV 197
Query: 199 GTFKLTIQHKITQVPIVYTASE--------VSNAQVNI-PTFHNLERNEIQENGNKSENE 249
+I + Y S + A + + PTF+ + E + +
Sbjct: 198 PWLDPFASRRIEMIRAKYKYSSPDRHVFLVLEMAAIRLGPTFYKVVYYEDETKNMRVSTS 257
Query: 250 VKISLGKSHESTLFFY-DPDQYNTDLIEEKFRRLERSSRETDTEKY--IKPDAKKRDVLN 306
V +G T + DP+ L E K + R R+ + E++ +KP+ + +D L
Sbjct: 258 VNGGVGIVSACTRYCVADPELLLESLAEVKHSAMTRRIRDVEDERHRQVKPNKQAKDRLE 317
Query: 307 AIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLMDIWAE 366
I+ P LT ++ L+WK+R+YL KAL K L+S N E+K L LM+ W
Sbjct: 318 TIVNLPSSQVLTREQRDLVWKFRHYLRQFPKALNKYLRSVNWVHPQEVKTALALMNDWEL 377
Query: 367 IDLDDTMELLGPQYTNISVRSYAVNRLRKA-SDNELELYLLQLVQSVCFECTSTLSDKSN 425
I+ +D +ELL +T+ +VR+Y+V+RL +A S ++ LYL QLVQ++ +E L ++ N
Sbjct: 378 IEAEDALELLSSAFTHPAVRAYSVSRLLEAASPEQVLLYLPQLVQALKYEQGQQLPEEGN 437
Query: 426 -------SEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKN 478
E I ++ + ++ D+ + + LA FLI A+ +
Sbjct: 438 PVPVVSEEEGKIPSVATTPTEELEGRDMT-----VVTKKEARKAASGDLATFLIDYALAS 492
Query: 479 FRLGNFFYWYLRSESERNTFLVHILESFKSRLPEHSKK---------------------- 516
++ N+ YW+L++E +ES K EHSK
Sbjct: 493 PKVSNYLYWHLKTE----------IESTKESKEEHSKMYQNIQDRLMEALVKRPDTRAQV 542
Query: 517 -TIDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITLPLDPDVI 575
++ Q + V+ L E K + + + SR + + K + LPLDP
Sbjct: 543 DSLHQQQIFVEDLIILMNEAKARGGRLNESKSAEFRTMLSRAKHMLDLKGVHLPLDPSFR 602
Query: 576 AVDVIPSSCKVFKSSLSPLKITF--LTANG-------QHYSLMFKVGDDLIQDQLVVQII 626
VIP + FKS + P KI+F L NG + Y+++FK GDDL QDQL+ Q++
Sbjct: 603 LSSVIPDTASFFKSEMMPAKISFKVLQPNGKADRNIPEEYTVIFKTGDDLRQDQLIQQMV 662
Query: 627 KLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSILSVHHG-----ILKYLQQ 681
+L+D +LK +DLKLTPY +L+TG +G + I ++ + +I + I + +++
Sbjct: 663 RLIDIILKKGQLDLKLTPYLVLSTGVGQGFVQCIKSKPLRAIQEQYKAHKMDCIREAMKE 722
Query: 682 NYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYIL 741
P G+EP V+DN+V+S AGY VI YILG+GDRHLDNLL+ +GK FH DFG+IL
Sbjct: 723 LRPGDGPF-GIEPNVIDNYVRSLAGYSVIMYILGLGDRHLDNLLLCENGKLFHVDFGFIL 781
Query: 742 GYDXXXXXXXXXXXXQIIEAFGGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTS 801
G D ++++ GG S + +F + AY ILRR++ +++NLF LM +
Sbjct: 782 GRDPKPMPPPMKLTSEMVQVMGGVKSKQFLEFVQHVDSAYRILRRHSNVLLNLFSLMLDA 841
Query: 802 DIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNLITTSVNALIPLVIDHLHNLAQ 858
IP+I +P+ A+ K+ ++ DLS+E AT H I +S+NA + ++ D +H Q
Sbjct: 842 GIPDIAAEPDKAIFKIEQRLRLDLSDEAATKHIFTQIESSLNAKMAMISDIIHAYKQ 898
>CE24760 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 650
Score = 327 bits (838), Expect = 5e-89
Identities = 209/640 (32%), Positives = 334/640 (51%), Gaps = 63/640 (9%)
Query: 266 DPDQYNTDLIEEKFRRLERSSRETDTEKY--IKPDAKKRDVLNAIIASPPGTKLTDHEKG 323
DP+ L E K + R R+ + E++ +KP+ + +D L I+ P LT ++
Sbjct: 24 DPELLLESLAEVKHSAMTRRIRDVEDERHRQVKPNKQAKDRLETIVNLPSSQVLTREQRD 83
Query: 324 LIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLMDIWAEIDLDDTMELLGPQYTNI 383
L+WK+R+YL KAL K L+S N E+K L LM+ W I+ +D +ELL +T+
Sbjct: 84 LVWKFRHYLRQFPKALNKYLRSVNWVHPQEVKTALALMNDWELIEAEDALELLSSAFTHP 143
Query: 384 SVRSYAVNRLRKA-SDNELELYLLQLVQSVCFECTSTLSDKSN-------SEFTIVNIEN 435
+VR+Y+V+RL +A S ++ LYL QLVQ++ +E L ++ N E I ++
Sbjct: 144 AVRAYSVSRLLEAASPEQVLLYLPQLVQALKYEQGQQLPEEGNPVPVVSEEEGKIPSVAT 203
Query: 436 SNNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFRLGNFFYWYLRSESER 495
+ ++ D+ + + LA FLI A+ + ++ N+ YW+L++E
Sbjct: 204 TPTEELEGRDMT-----VVTKKEARKAASGDLATFLIDYALASPKVSNYLYWHLKTE--- 255
Query: 496 NTFLVHILESFKSRLPEHSKK-----------------------TIDDQILLVDMLRKFC 532
+ES K EHSK ++ Q + V+ L
Sbjct: 256 -------IESTKESKEEHSKMYQNIQDRLMEALVKRPDTRAQVDSLHQQQIFVEDLIILM 308
Query: 533 EEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITLPLDPDVIAVDVIPSSCKVFKSSLS 592
E K + + + SR + + K + LPLDP VIP + FKS +
Sbjct: 309 NEAKARGGRLNESKSAEFRTMLSRAKHMLDLKGVHLPLDPSFRLSSVIPDTASFFKSEMM 368
Query: 593 PLKITF--LTANG-------QHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLT 643
P KI+F L NG + Y+++FK GDDL QDQL+ Q+++L+D +LK +DLKLT
Sbjct: 369 PAKISFKVLQPNGKADRNIPEEYTVIFKTGDDLRQDQLIQQMVRLIDIILKKGQLDLKLT 428
Query: 644 PYNILATGKNEGAIGFIPNETMSSILSVHHG-----ILKYLQQNYPSQAEIDGVEPWVMD 698
PY +L+TG +G + I ++ + +I + I + +++ P G+EP V+D
Sbjct: 429 PYLVLSTGVGQGFVQCIKSKPLRAIQEQYKAHKMDCIREAMKELRPGDGPF-GIEPNVID 487
Query: 699 NFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXXXXXXXXXXQI 758
N+V+S AGY VI YILG+GDRHLDNLL+ +GK FH DFG+ILG D ++
Sbjct: 488 NYVRSLAGYSVIMYILGLGDRHLDNLLLCENGKLFHVDFGFILGRDPKPMPPPMKLTSEM 547
Query: 759 IEAFGGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVM 818
++ GG S + +F + AY ILRR++ +++NLF LM + IP+I +P+ A+ K+
Sbjct: 548 VQVMGGVKSKQFLEFVQHVDSAYRILRRHSNVLLNLFSLMLDAGIPDIAAEPDKAIFKIE 607
Query: 819 EKFAFDLSEEDATIHFQNLITTSVNALIPLVIDHLHNLAQ 858
++ DLS+E AT H I +S+NA + ++ D +H Q
Sbjct: 608 QRLRLDLSDEAATKHIFTQIESSLNAKMAMISDIIHAYKQ 647
>7291607 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 1157
Score = 284 bits (727), Expect = 4e-76
Identities = 158/410 (38%), Positives = 240/410 (58%), Gaps = 31/410 (7%)
Query: 467 LAEFLIRRAVKNFRLGNFFYWYL----------RSESER-NTFLVHILESFKSRLPEHS- 514
L FLI+RA N L N+FYWYL R + ER + +L+ F L +
Sbjct: 533 LCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMFLKVLENGNF 592
Query: 515 ------------KKTIDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMRSLFK 562
++ ID+ + LV ++ K E + T K Q++L + F
Sbjct: 593 NLRGIFYNLRKQRRFIDELVKLVKLVAK---EPGNRNKKTEKFQKLLAE--QDMFKVNFT 647
Query: 563 N-KAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTANGQH-YSLMFKVGDDLIQDQ 620
N + I PLDP++ ++P +FKS+L P K+TF+T+ H Y+ +FK GDDL QDQ
Sbjct: 648 NFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQ 707
Query: 621 LVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSILSVHHGILKYLQ 680
L++Q+I LMD+LL+ EN+DLKLTPY +LAT G + ++ + T++ +L+ I + +
Sbjct: 708 LILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFR 767
Query: 681 QNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYI 740
+++P G+ VMD ++KSCAGYCVITY+LGVGDRHLDNLL+ +GK FH DFGYI
Sbjct: 768 KHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYI 827
Query: 741 LGYDXXXXXXXXXXXXQIIEAFGGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKT 800
LG D +++EA GG S ++ +FR C+ AY LRR+A +++NLF LM
Sbjct: 828 LGRDPKPMPPPMKLSKEMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVD 887
Query: 801 SDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNLITTSVNALIPLVI 850
+ +P+I ++P+ AV KV E L++E+A H Q+L+ S+ A++P ++
Sbjct: 888 ATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALV 937
Score = 147 bits (371), Expect = 7e-35
Identities = 126/448 (28%), Positives = 204/448 (45%), Gaps = 45/448 (10%)
Query: 20 VKIINLEGSSALLKQSEKYTEPDLSKRASNFIPNSDMFVSLQVFDGETGRNLTIPVYTKY 79
+K+ LEG + +P L + V LQVF+ GR +PV + Y
Sbjct: 22 IKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFN--QGRPYCLPVTSSY 79
Query: 80 VPFKNSRVWDQWLTLPIKINQLDMTSTLLIELWEYNGDTR---------SIFAKLETQIF 130
F W++W+TLP++ + L ++ L++ + + +G + S+F K +F
Sbjct: 80 KAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGK--DGMF 137
Query: 131 NSHDYSLK-----RGREVFKF-TKDNEKRALPMKDQNIA-LINDYHTGELKTSQWLDNSV 183
Y L+ G F T K + + Q + L + G+++ WLD
Sbjct: 138 RQGMYDLRVWLGVEGDGNFPSRTPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLT 197
Query: 184 ISALEEQVKGEKLPLGTFKLTIQHKITQVPIVYTASEVSNAQVNIPTFHNLERNEIQENG 243
+E + EK L I+ V +Y + V
Sbjct: 198 FREIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYF-------------------- 237
Query: 244 NKSENEVKISLGKSHESTLFFYDPDQYNTDLIEEKFRRLERSSRETDTEKYIKPDAKKRD 303
+ E +VK L + + D + +L+E K RL RS R +++ KP A RD
Sbjct: 238 -EPEGDVKYKL-PAKPKLVSVPDSEIQMENLVERKHHRLARSERSGISDRDAKPTASIRD 295
Query: 304 VLNAIIAS-PPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLMD 362
L+ I+ PP L+ E+ L+WK+R+YLS++KKALTK L+ N E E+ + L ++
Sbjct: 296 QLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLEDEVTQALWMLA 355
Query: 363 IWAEIDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFECTSTLSD 422
WA +D++D +ELL P +T+ VR YAV+RL +A D +L LYLLQLVQ++ +E +
Sbjct: 356 NWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYEDPRHIVH 415
Query: 423 KSNSEFTIVNIENSNNDQNYSGDIIDAS 450
F ++ S D N G ++D S
Sbjct: 416 LHGCIFPERDVVRSILDDN--GSLLDQS 441
>Hs19923289 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1044
Score = 236 bits (603), Expect = 9e-62
Identities = 166/559 (29%), Positives = 265/559 (46%), Gaps = 81/559 (14%)
Query: 305 LNAIIASPPGTKLTDHEKGLIWKYRYYLSNN-KKALTKLLQSTNLSEESEIKEVLDLMDI 363
L I+ +L +HEK L+WK R+ + + +AL +LL T ++ ++ ++L L+
Sbjct: 511 LREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCS 570
Query: 364 WAEIDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFECTSTLSDK 423
W E+ + +ELL + + V S+A+ LRK +D+EL YLLQLVQ + +E
Sbjct: 571 WPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYE-------- 622
Query: 424 SNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFRLGN 483
S + L +FL+ RA+ N ++G+
Sbjct: 623 -------------------------------------SYLDCELTKFLLDRALANRKIGH 645
Query: 484 FFYWYLRSESERNTFLVH---ILESFKSRLPEHSKKTIDDQILLVDMLRKFCEEIKQSKE 540
F +W+LRSE + + ILE++ R H K + Q + L+ + +K S +
Sbjct: 646 FLFWHLRSEMHVPSVALRFGLILEAY-CRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQ 704
Query: 541 TTVKKQ-EILLHLISSRMRSLFKNKAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFL 599
T K Q + L+HL + L + PLDP + +V C S + PL I +
Sbjct: 705 KTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYS 764
Query: 600 T---ANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGA 656
+G ++FK GDDL QD L +Q+I+LMD L K E +DL++TPY L TG G
Sbjct: 765 NEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGL 824
Query: 657 IGFIPNETMSSILSVHHG------------ILKYLQQNYPSQAEIDGVEPWVMDNFVKSC 704
I + + + ++ +L +L+ P +A +E F SC
Sbjct: 825 IEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIE-----EFTLSC 879
Query: 705 AGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXX--------XXXXXXXX 756
AGYCV TY+LG+GDRH DN++I+ G+ FH DFG+ LG
Sbjct: 880 AGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFV 939
Query: 757 QIIEAFGGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLK 816
+I+ +S +++FR YC AY+ILRR+ L ++LF LM+ + +P + + LK
Sbjct: 940 HVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLK 999
Query: 817 VMEKFAFDLSEEDATIHFQ 835
+ A +EE+A HF+
Sbjct: 1000 --DSLALGKTEEEALKHFR 1016
>Hs15451926 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1634
Score = 221 bits (562), Expect = 5e-57
Identities = 152/568 (26%), Positives = 269/568 (46%), Gaps = 84/568 (14%)
Query: 317 LTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLMDIWAEIDLDDTMELL 376
LTD +K +W+ RYY + +L +L S E + + ++ L+ W ++ D + LL
Sbjct: 831 LTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLL 890
Query: 377 GPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFECTSTLSDKSNSEFTIVNIENS 436
+ + VR AV + SD EL YL QLVQ++ +EC
Sbjct: 891 HATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYEC-------------------- 930
Query: 437 NNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFRLGNFFYWYLRSESERN 496
+ SPL FL++RAV + R+ ++F+W L+ + +
Sbjct: 931 -------------------------YLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDS 965
Query: 497 TFLV---HILESFKSRLPEHSKKTIDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLI 553
F + ++L + + ++ + Q LV+ L K ++++++ + +Q IL +
Sbjct: 966 QFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSA--RQGILRTGL 1023
Query: 554 SSRMRSLFKNKAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTAN--GQHYSLMFK 611
+ N + LPL P ++ ++P C F S+ PLK++F + G++ ++FK
Sbjct: 1024 EEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFK 1083
Query: 612 VGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSILSV 671
GDDL QD L +Q+I++M ++ E +D+++ + +TG+ G + IPN + V
Sbjct: 1084 CGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQV 1143
Query: 672 HHGIL---------KYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLD 722
HG+ +LQ++ P + E + ++NF+ SCAG CV TY+LG+ DRH D
Sbjct: 1144 EHGVTGSFKDRPLADWLQKHNPGEDEYEKA----VENFIYSCAGCCVATYVLGICDRHND 1199
Query: 723 NLLIQPDGKFFHADFGYILGY-----DXXXXXXXXXXXXQIIEAFGGTD--SANYDKFRS 775
N++++ G FH DFG LG+ + + G D S+ + F
Sbjct: 1200 NIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVD 1259
Query: 776 YCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDL-----SEEDA 830
C AY+++R++ L +NL LM + IP + D E K+ +D +E +A
Sbjct: 1260 LCCQAYNLIRKHTHLFLNLLGLMLSCGIPELS-DLEDL------KYVYDALRPQDTEANA 1312
Query: 831 TIHFQNLITTSVNALIPLVIDHLHNLAQ 858
T +F LI +S+ ++ + +HNLAQ
Sbjct: 1313 TTYFTRLIESSLGSVATKLNFFIHNLAQ 1340
>Hs4505799 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1686
Score = 217 bits (552), Expect = 7e-56
Identities = 148/563 (26%), Positives = 265/563 (46%), Gaps = 75/563 (13%)
Query: 317 LTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLMDIWAEIDLDDTMELL 376
L+ +K +W+ RYY + L K+L S + + + L+ W + +ELL
Sbjct: 887 LSKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWGNLAKTYSLLHQWPALYPLIALELL 946
Query: 377 GPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFECTSTLSDKSNSEFTIVNIENS 436
++ + VRS AV + SD+EL L Q VQ++ +E
Sbjct: 947 DSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEI-------------------- 986
Query: 437 NNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFRLGNFFYWYLRS---ES 493
+ S L +FL+ RA+ N ++ + YW L+ +
Sbjct: 987 -------------------------YLNSSLVQFLLSRALGNIQIAHNLYWLLKDALHDV 1021
Query: 494 ERNTFLVHILESFKSRLPEHSKKTIDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLI 553
+ +T H+L + S + ++ + Q LV +L E+++Q+ + ++++L
Sbjct: 1022 QFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSA---RQVVLQRS 1078
Query: 554 SSRMRSLFKNKAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTAN--GQHYSLMFK 611
R++S F+ LPL P ++A ++ SC F S+ PLK+T + A+ G+ ++MFK
Sbjct: 1079 MERVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPLGEEINVMFK 1138
Query: 612 VGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSILSV 671
VG+DL QD L +Q+IK+MD++ E +DL++ + L+TG++ G + +P + V
Sbjct: 1139 VGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKIQV 1198
Query: 672 HHGIL---------KYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLD 722
+G+ ++L++ PS+ E + +NF+ SCAG CV TY+LG+ DRH D
Sbjct: 1199 EYGVTGSFKDKPLAEWLRKYNPSEEEYEKAS----ENFIYSCAGCCVATYVLGICDRHND 1254
Query: 723 NLLIQPDGKFFHADFGYILGYDXXXXXXXXXXXXQIIEA-------FGGTDSANYDKFRS 775
N++++ G FH DFG LG+ ++ + G + + F
Sbjct: 1255 NIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVD 1314
Query: 776 YCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQ 835
C AY+++R+ L +NL LM S +P + + + V + ++ +ATI F
Sbjct: 1315 LCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQD--LKYVRDALQPQTTDAEATIFFT 1372
Query: 836 NLITTSVNALIPLVIDHLHNLAQ 858
LI +S+ ++ +HNLAQ
Sbjct: 1373 RLIESSLGSIATKFNFFIHNLAQ 1395
>HsM4505803 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1101
Score = 214 bits (546), Expect = 3e-55
Identities = 157/572 (27%), Positives = 266/572 (46%), Gaps = 86/572 (15%)
Query: 302 RDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLM 361
R L AIIA+ P LT +K L+W +RY + KA KL S ++ + + L+
Sbjct: 551 RKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLL 610
Query: 362 ---DIWAE--IDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFEC 416
++W + +D+ TM+LL +++ +VR+ AV +L D+++ YLLQLVQ+V FE
Sbjct: 611 ARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEP 670
Query: 417 TSTLSDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAV 476
S LA FL++R +
Sbjct: 671 YHD---------------------------------------------SALARFLLKRGL 685
Query: 477 KNFRLGNFFYWYLRSESERNTFLVH----ILESFKSRLPEHSKKTIDDQILLVDMLRKFC 532
+N R+G+F +W+LRSE ++ ILE++ Q+ +++ML+K
Sbjct: 686 RNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVT 745
Query: 533 EEIKQSKETTVKKQEILLHLISSRMRSLFKNK---AITLPLDPDVIAVDVIPSSCKVFKS 589
+IK ++ + ++ +L ++ + +P DP + A + CKV S
Sbjct: 746 LDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMAS 805
Query: 590 SLSPLKITFLTAN-----GQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTP 644
PL + F A+ + ++FK GDDL QD L++QI+++M+ + + E++DL L P
Sbjct: 806 KKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLP 865
Query: 645 YNILATGKNEGAIGFIPNETMSSILSV----HHGILK------YLQQNYPSQAEIDGVEP 694
Y ++TG G I + + T + + + G K +L++ P++ +
Sbjct: 866 YGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAA-- 923
Query: 695 WVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILG-YDXXXXXXXXX 753
++ FV SCAGYCV T++LG+GDRH DN++I G FH DFG+ILG Y
Sbjct: 924 --VERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKER 981
Query: 754 XXXQIIEAF-------GGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNI 806
+ F G S ++ KF+ C AY LR + L+I LF +M + +P +
Sbjct: 982 VPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL 1041
Query: 807 KMDPEGAVLKVMEKFAFDLSEEDATIHFQNLI 838
+ + + + +EEDA +F + I
Sbjct: 1042 TSKED--IEYIRDALTVGKNEEDAKKYFLDQI 1071
>Hs21237725 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1102
Score = 214 bits (546), Expect = 3e-55
Identities = 157/572 (27%), Positives = 266/572 (46%), Gaps = 86/572 (15%)
Query: 302 RDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLM 361
R L AIIA+ P LT +K L+W +RY + KA KL S ++ + + L+
Sbjct: 552 RKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLL 611
Query: 362 ---DIWAE--IDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFEC 416
++W + +D+ TM+LL +++ +VR+ AV +L D+++ YLLQLVQ+V FE
Sbjct: 612 ARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEP 671
Query: 417 TSTLSDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAV 476
S LA FL++R +
Sbjct: 672 YHD---------------------------------------------SALARFLLKRGL 686
Query: 477 KNFRLGNFFYWYLRSESERNTFLVH----ILESFKSRLPEHSKKTIDDQILLVDMLRKFC 532
+N R+G+F +W+LRSE ++ ILE++ Q+ +++ML+K
Sbjct: 687 RNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVT 746
Query: 533 EEIKQSKETTVKKQEILLHLISSRMRSLFKNK---AITLPLDPDVIAVDVIPSSCKVFKS 589
+IK ++ + ++ +L ++ + +P DP + A + CKV S
Sbjct: 747 LDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMAS 806
Query: 590 SLSPLKITFLTAN-----GQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTP 644
PL + F A+ + ++FK GDDL QD L++QI+++M+ + + E++DL L P
Sbjct: 807 KKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLP 866
Query: 645 YNILATGKNEGAIGFIPNETMSSILSV----HHGILK------YLQQNYPSQAEIDGVEP 694
Y ++TG G I + + T + + + G K +L++ P++ +
Sbjct: 867 YGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAA-- 924
Query: 695 WVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILG-YDXXXXXXXXX 753
++ FV SCAGYCV T++LG+GDRH DN++I G FH DFG+ILG Y
Sbjct: 925 --VERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKER 982
Query: 754 XXXQIIEAF-------GGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNI 806
+ F G S ++ KF+ C AY LR + L+I LF +M + +P +
Sbjct: 983 VPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL 1042
Query: 807 KMDPEGAVLKVMEKFAFDLSEEDATIHFQNLI 838
+ + + + +EEDA +F + I
Sbjct: 1043 TSKED--IEYIRDALTVGKNEEDAKKYFLDQI 1072
>Hs5453892 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1068
Score = 213 bits (542), Expect = 1e-54
Identities = 155/561 (27%), Positives = 268/561 (47%), Gaps = 77/561 (13%)
Query: 302 RDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLM 361
++ L AI P +++T+ EK +W +R+Y + L KLL S + E+ ++ L+
Sbjct: 528 KEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLV 587
Query: 362 DIWAEIDLDDTMELLGPQYTNISVRSYAVNRLRK-ASDNELELYLLQLVQSVCFECTSTL 420
W I + MELL Y + VR +AV L K +D++L YL+QLVQ + +E
Sbjct: 588 KDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYE----- 642
Query: 421 SDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFR 480
Q+L N L FL+++A+ N R
Sbjct: 643 ------------------------------QYLDNL----------LVRFLLKKALTNQR 662
Query: 481 LGNFFYWYLRSESERNTFLVH---ILESFKSRLPEHSKKTIDDQILLVDMLRKFCEEIKQ 537
+G+FF+W+L+SE T +LES+ R K ++ Q+ ++ L + +KQ
Sbjct: 663 IGHFFFWHLKSEMHNKTVSQRFGLLLESY-CRACGMYLKHLNRQVEAMEKLINLTDILKQ 721
Query: 538 SKETTVKKQEILLHLISSRMRSLFKN--KAITLPLDPDVIAVDVIPSSCKVFKSSLSPLK 595
++ +K ++ L+ R F + + + PL+P ++ C++ S+ PL
Sbjct: 722 ERKDETQKVQMKF-LVEQMRRPDFMDALQGLLSPLNPAHQLGNLRLKECRIMSSAKRPLW 780
Query: 596 ITFLTAN------GQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILA 649
+ + + Q+ ++FK GDDL QD L +QII++M+ + +N+ +DL++ PY L+
Sbjct: 781 LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS 840
Query: 650 TGKNEGAIGFIPNETMSSILSVHHGILKYLQQN------YPSQAEIDGVEPWVMDNFVKS 703
G G I + N + G+ LQ N + + +D F +S
Sbjct: 841 IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS 900
Query: 704 CAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYIL-------GYDXXXXXXXXXXXX 756
CAGYCV T+ILG+GDRH N++++ DG+ FH DFG+ L GY
Sbjct: 901 CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF 960
Query: 757 QIIEAFGG---TDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGA 813
I+ + G T + +++F+ C+ AY +R++A L INLF +M S +P ++ + A
Sbjct: 961 LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA 1020
Query: 814 VLKVMEKFAFDLSEEDATIHF 834
++ + A D +E++A +F
Sbjct: 1021 YIR--KTLALDKTEQEALEYF 1039
>7300643 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1088
Score = 205 bits (521), Expect = 3e-52
Identities = 189/722 (26%), Positives = 330/722 (45%), Gaps = 103/722 (14%)
Query: 149 DNEKRALPMKDQNIALINDYHTGELKTSQWLDNSVISALEEQVKGEKLPLGTFKLTI-QH 207
D + R LP + +I + ++ S+ N+ AL++ V K PL TI H
Sbjct: 407 DIQMRNLPRMTRLCIVI--FEVTKMSRSKKSSNNKDIALKD-VPYNKNPLAWVNTTIFDH 463
Query: 208 KI---TQVPIVYTASEVSNAQVNIPTFHNLERNEIQENGNKSENE-VKISLGKSHESTLF 263
K T +YT + + Q ++ FH L I+ N K E V ++ S T+
Sbjct: 464 KDILRTGRHTLYTWTYADDIQ-SVEVFHPL--GTIEPNPRKEECALVDLTFLSSGTGTVR 520
Query: 264 FYDPD---QYNTDLIEEKFRRLERSSRETDTEKYIKPDAKKRDVLNAIIASPPGTKLTDH 320
+ + QY D E+ RL+R + KP + ++++ ++ D
Sbjct: 521 YPSEEVVLQYAAD--REQVNRLQRQLAGPE-----KPIKELKELMANYTGLDKIYEMVDQ 573
Query: 321 EKGLIWKYRY-YLSNNKKALTKLLQSTNLSEESEIKEVLDLMDIWAEIDLDDTMELLGPQ 379
++ IW+ R L + L+ LL E ++ ++ L+ W I ++ ++ELL
Sbjct: 574 DRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYA 633
Query: 380 YTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFECTSTLSDKSNSEFTIVNIENSNND 439
Y + +VR +A+ L D +L LYLLQLVQ++ E
Sbjct: 634 YPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHE------------------------ 669
Query: 440 QNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFRLGNFFYWYLRSESERNTFL 499
S + S L FL+ RA++N R+G++F+W+LRSE + +
Sbjct: 670 ---------------------SYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQ 708
Query: 500 VH---ILESFKSRLPEHSKKTIDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLISSR 556
+LE + +H + Q+ +++ L++ K+ + VK + L R
Sbjct: 709 TRFGLLLEVYLKGC-KHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKVKTM-LQDFLRDQR 766
Query: 557 MRSLFKNKAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTA--NGQHYSLMFKVGD 614
++F+N I PL+P V P CKV S + PL + F A N ++FK GD
Sbjct: 767 NSAVFQN--IQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGD 824
Query: 615 DLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPN-ETMSSILSVHH 673
DL QD L +Q++++MDQL K + +D ++ YN ++ K+ G I + + ET+++I
Sbjct: 825 DLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKG 884
Query: 674 -----------GILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLD 722
+L +L+++ +++ ++ F SCAGYCV TY+LGV DRH D
Sbjct: 885 MFSATSPFKKGSLLSWLKEHNKPADKLNKA----INEFTLSCAGYCVATYVLGVADRHSD 940
Query: 723 NLLIQPDGKFFHADFGYILGY---------DXXXXXXXXXXXXQIIEAFGGTDSANYDKF 773
N++++ +G+ FH DFG+ILG+ + I + F +S + F
Sbjct: 941 NIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHF 1000
Query: 774 RSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIH 833
+ C A+ +LR++ LI++LF +M ++ +P + + + L+ E D +EE A H
Sbjct: 1001 QELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLR--ETLVLDYTEEKAREH 1058
Query: 834 FQ 835
F+
Sbjct: 1059 FR 1060
>Hs5453894 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1070
Score = 203 bits (517), Expect = 8e-52
Identities = 167/561 (29%), Positives = 259/561 (45%), Gaps = 84/561 (14%)
Query: 304 VLNAIIASPPGTKLTDHEKGLIWKYRYYLSNN-KKALTKLLQSTNLSEESEIKEVLDLMD 362
VL I+ P ++L ++E LIW R ++L KLL S ++ ++ ++ L+
Sbjct: 537 VLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQ 596
Query: 363 IWAEIDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFECTSTLSD 422
IW ++ + +ELL Y + VR YAV LR+ SD EL YLLQLVQ + +E
Sbjct: 597 IWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYE------- 649
Query: 423 KSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFRLG 482
+D + L+ FL+ RA+ N R+G
Sbjct: 650 ----------------------PFLDCA----------------LSRFLLERALGNRRIG 671
Query: 483 NFFYWYLRSESERNTFLVH---ILESFKSRLPEHSKKTIDDQILLVDMLRKFCEEIKQS- 538
F +W+LRSE V ILE++ H K + Q+ ++ L+ IK +
Sbjct: 672 QFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMK-VLSKQVEALNKLKTLNSLIKLNA 730
Query: 539 -KETTVKKQEIL-LHLISSRMRSLFKNKAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKI 596
K K +E + L S R + + PL+P VI ++ CK S + PL +
Sbjct: 731 VKLNRAKGKEAMHTCLKQSAYREALSD--LQSPLNPCVILSELYVEKCKYMDSKMKPLWL 788
Query: 597 TFLTA--NGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNE 654
+ ++FK GDDL QD L +Q+++LMD L K +DL++ PY LATG
Sbjct: 789 VYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRS 848
Query: 655 GAIGFIP-NETMSSILSVHHGI-----------LKYLQQNYPSQAEIDGVEPWVMDNFVK 702
G I + +ET++ I + L +L++ Y S ++D ++ F
Sbjct: 849 GLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKE-YNSGDDLDRA----IEEFTL 903
Query: 703 SCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXX--------XXXXXX 754
SCAGYCV +Y+LG+GDRH DN++++ G+ FH DFG+ILG
Sbjct: 904 SCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYD 963
Query: 755 XXQIIEAFGGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAV 814
+I+ ++ + +FR C AY ILRR+ L I LF LM T+ +P + +
Sbjct: 964 FIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQY 1023
Query: 815 LKVMEKFAFDLSEEDATIHFQ 835
LK + A SEE+A F+
Sbjct: 1024 LK--DSLALGKSEEEALKQFK 1042
>Hs4758924 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1448
Score = 194 bits (493), Expect = 5e-49
Identities = 147/561 (26%), Positives = 266/561 (47%), Gaps = 70/561 (12%)
Query: 317 LTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLMDIWAEIDLDDTMELL 376
L++ +K +W YR+Y +N +L +L S +E + E+ ++ W + + LL
Sbjct: 669 LSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLL 728
Query: 377 GPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFECTSTLSDKSNSEFTIVNIENS 436
+ + +R AV +L DN L LL+
Sbjct: 729 TSSFPDQEIRKVAVQQL----DNLLNDELLE----------------------------- 755
Query: 437 NNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFRLGNFFYWYLRSESERN 496
Y ++ A +F N + SPL + L+ R++++ ++ + YW L++ +E
Sbjct: 756 -----YLPQLVQAVKFEWN-------LESPLVQLLLHRSLQSIQVAHRLYWLLKN-AENE 802
Query: 497 TFLVHILESFKSRLPEHSKKTIDDQIL----LVDMLRKFCEEIKQSKETTVKKQEILLHL 552
+ + + L + K ++D+ L+ +L E +K + + ++QE+L
Sbjct: 803 AYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDH--QRQEVLKKE 860
Query: 553 ISSRMRSLFKN-KAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTAN--GQHYSLM 609
I R+ F++ LPL+P + + +C F S+ PLKITF+ AN G++ S++
Sbjct: 861 IG-RLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANLMGKNISII 919
Query: 610 FKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSIL 669
FK GDDL QD LV+Q+I++MD + E +D+++ Y L+TGK++ + +P+ + +
Sbjct: 920 FKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQRLVQMVPDAVTLAKI 979
Query: 670 SVHHGILKYLQQN-----YPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNL 724
H G++ L++N + + + NF SCAG+CV+T+ILGV DRH DN+
Sbjct: 980 HRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNI 1039
Query: 725 LIQPDGKFFHADFGYILGYDXXXXXXXXXXXXQI----IEAF---GGTDSANYDKFRSYC 777
++ G FH DFG LG+ I +E F GG + ++ F C
Sbjct: 1040 MLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELC 1099
Query: 778 FVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNL 837
AY+I+R+++ L++NL E+M + +P + + + V ++ +AT HF
Sbjct: 1100 CRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQD--LKYVYNNLRPQDTDLEATSHFTKK 1157
Query: 838 ITTSVNALIPLVIDHLHNLAQ 858
I S+ + + +H LAQ
Sbjct: 1158 IKESLECFPVKLNNLIHTLAQ 1178
>CE05832 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1607
Score = 182 bits (463), Expect = 1e-45
Identities = 149/593 (25%), Positives = 252/593 (42%), Gaps = 90/593 (15%)
Query: 298 DAKKRDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEV 357
D + ++ L +I + + L ++ LIW+ R +L+N +AL +L S + V
Sbjct: 783 DIETQEYLLELIENQDTSTLETDDQDLIWQKRLHLTNQPEALPLVLSSLQDWSFGFVMRV 842
Query: 358 LDLMDIWAEIDLDDTMELLGPQYTNISVRSYAVNRLRKASDNELELYLLQLVQSVCFECT 417
+++ WA + + ME L P+Y + +R++AV L + S + L + Q ++++ FE
Sbjct: 843 YQILEEWAPLRPEIAMEFLLPKYPDERIRAHAVQSLARGSTDFLYHTIPQFIEALRFEL- 901
Query: 418 STLSDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVK 477
++K S LA+F++ +
Sbjct: 902 ---------------------------------------YEK-----SALADFILELSFV 917
Query: 478 NFRLGNFFYWYLRSESERNT-----FLVHILESFKSRLPEHSKKTIDDQILLVDMLRKFC 532
+ YW L+ + + + + + EH + I L L
Sbjct: 918 SLDFTFEIYWQLQQRVDHCAVDDLPYAIRCQNLQQKMIDEHENPNLKTDIKLQHELLNEL 977
Query: 533 EEIKQSKETTVKKQEI-LLHLISSRM----RSLFKNKAITLPLDPDVIAVDVIPSSCKVF 587
+ I+ + EI LH + +R+ L +NK + LP+ P V C VF
Sbjct: 978 DSIQDDLRSKSGDSEIERLHRLRTRLGILDSKLLQNK-VRLPICPAFDCTGVRIEECSVF 1036
Query: 588 KSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNI 647
S+ PLKI F N +YS++ K DD+ QD V++++ MD++ K+ +DL++ + I
Sbjct: 1037 NSNAKPLKIVFRGLN-MNYSIIHKRDDDMRQDAFVMKMLNEMDRIWKSNGLDLRMITFRI 1095
Query: 648 LATGKNEGAIGFIPNETMSSILSVHHGILKYLQQNYPSQAEIDGVEPWVM---------- 697
+ G G + N + G+ L + W+M
Sbjct: 1096 MPVGYRRGMGELVLNCATLMEIQKEEGLRGVLNDEI--------LRKWLMKHNSDEFAYK 1147
Query: 698 ---DNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXXXXXXXX 754
+NF++SCAG+C++TY+LG+GDRH DN+L +G FH DFG +G D
Sbjct: 1148 EAQENFIRSCAGWCIVTYVLGIGDRHNDNILFTKNGHVFHIDFGKYMG-DWQMAAGFRRD 1206
Query: 755 XXQII---EAF-----GGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNI 806
+ E F G + KF YC A++ LRRN + NL +M SDIP I
Sbjct: 1207 RVPFVFTTEMFHVINNGRAPTQYNQKFIDYCCKAFNHLRRNKNTLTNLLRIMACSDIPGI 1266
Query: 807 KMDPEGAVLKVMEKFAFDLSEEDATIHFQNLITTSVNALIPLVIDHLHNLAQY 859
MD ++ V DLS+ DAT+ F +I S+ + + H +AQ+
Sbjct: 1267 NMD---SLAFVENNLMLDLSDTDATVQFTAMIQNSLGSAFVRLNFVAHTVAQF 1316
>7294673 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1876
Score = 174 bits (441), Expect = 5e-43
Identities = 144/573 (25%), Positives = 246/573 (42%), Gaps = 90/573 (15%)
Query: 324 LIWKYRYYLSNNKKALTKLLQSTNLSEESEIKEVLDLMDIWAEIDLDDTMELLGPQYTNI 383
+ W+ R YL + AL K+L + + + + + ++ L+ WA + ++ELL P+Y +
Sbjct: 1063 VFWEKRLYLQSYPNALPKVLHAAHSWDYANLIDLHALLHSWAPLSPLQSLELLLPRYPDA 1122
Query: 384 SVRSYAVNRLRKASDNELELYLLQLVQSVCFECTSTLSDKSNSEFTIVNIENSNNDQNYS 443
VR AV + K +++L +L QLVQS+ Y
Sbjct: 1123 KVREKAVEWISKMPNDQLVDFLPQLVQSL-------------------------KHDTYE 1157
Query: 444 GDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFRLGNFFYWYL---RSESERNTFLV 500
G S +A FL+ + +++ R + YW L + N+
Sbjct: 1158 G--------------------SAMARFLLSKCLESPRFAHHMYWLLVHSLPDDPHNSIGA 1197
Query: 501 HIL-----ESFKSRLPEHSKKTIDDQILLV----DMLRKFCEEIKQSKETTVKKQEILLH 551
++ ES +++ + + + + L+ ML++F + + ++ T + +
Sbjct: 1198 AMVDQEYDESQVTQVRYYRRNKMMLRALMAICGEKMLQRFMYQHRMCQKLTTIAESVKEA 1257
Query: 552 LISSRMRSL----------FKNKAITLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTA 601
S R +SL + LPL P++ V +C F S+ PLKI F+
Sbjct: 1258 KESMRQKSLAAGMDEVHQDLLEQPTCLPLGPELEVTGVSVRNCSYFNSNTLPLKINFVGP 1317
Query: 602 NGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIP 661
+ + +FK GDDL QDQL +Q+I++M+++ E +DLK+ +N + TG G I +
Sbjct: 1318 DAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELVS 1377
Query: 662 NETMSSILSVHHG---------ILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITY 712
+ V G I ++L + PS E + NF SCAGY V TY
Sbjct: 1378 EAETLRKIQVECGLTGSFKDRPIAEWLGKQNPSPLEYQS----AVRNFTLSCAGYSVATY 1433
Query: 713 ILGVGDRHLDNLLIQPDGKFFHADFGYILG-------YDXXXXXXXXXXXXQIIEAFGGT 765
+LG+ DRH DN++++ G FH DFG LG + + G
Sbjct: 1434 VLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDK 1493
Query: 766 DSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDL 825
S ++ F C A++I+R+NA L+++ M T+ +P + AV V
Sbjct: 1494 PSTDFHYFVDLCCRAFNIVRKNADLLLHTLAHMATAGMPGVN---SNAVQYVRRALLPSQ 1550
Query: 826 SEEDATIHFQNLITTSVNALIPLVIDHLHNLAQ 858
S +A F +I +S+ + LHNLAQ
Sbjct: 1551 SNPEAAATFAKMIQSSLKSWFTQFNFFLHNLAQ 1583
>CE23506 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1146
Score = 156 bits (394), Expect = 1e-37
Identities = 151/619 (24%), Positives = 262/619 (41%), Gaps = 120/619 (19%)
Query: 290 DTEKYIK-PDAKKRDVLNAIIASPPGTKLTDHEKGLIWKYRYYLSNNKKALTKLLQSTNL 348
D E I+ P KK +L + G L + E+ +W +R Y+ + L +L
Sbjct: 566 DYESCIRDPGYKKLQML--VKKHESGIVLEEDEQRHVWMWRRYIQKQEPDLLIVLSELAF 623
Query: 349 --SEESEIKEVLDLMDIWAEIDLDDTMELLGPQYTNISVRSYAVNRLRKA-SDNELELYL 405
++ E+ +++ W + + LLG + T+ +R +AV +L + S L++
Sbjct: 624 VWTDRENFSELYVMLEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLNEQLSPVTFHLFI 683
Query: 406 LQLVQSVCFECTSTLSDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSFDKNSVMIS 465
L L+Q++ +E ++ SE ++
Sbjct: 684 LPLIQALKYE------PRAQSEVGMM---------------------------------- 703
Query: 466 PLAEFLIRRAVKNFRLGNFFYWYLRSE----------SERNTFLVHILESFKSRLPEHSK 515
L+ RA+ ++R+G+ +W LR+E SE + ++E++ EH K
Sbjct: 704 -----LLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEYRRISLLMEAYLRGNEEHIK 758
Query: 516 KTIDDQILLVDMLRKFCEEIK-QSKETTVKKQEILLHLISSRMRSLFKNKAITLPLDPDV 574
I Q+ +VD L + +K K+ K L IS +M ++ PLDP
Sbjct: 759 -IITRQVDMVDELTRISTLVKGMPKDVATMKLRDELRSISHKMENMDS------PLDPVY 811
Query: 575 IAVDVIPSSCKVFKSSLSPLKITFLTANGQH------YSLMFKVGDDLIQDQLVVQIIKL 628
++I V S+ PL + + N + +++FK GDDL QD LV+Q++++
Sbjct: 812 KLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDMLVLQVLEV 871
Query: 629 MDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSILSVHHGIL------------ 676
MD + K N+D L PY +L G+ G I +PN + V G +
Sbjct: 872 MDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFM 931
Query: 677 -KYLQQNY----------------PSQAEIDGVEPWV-----MDNFVKSCAGYCVITYIL 714
K++++ P + +ID + +D F+ SC GY V TYI+
Sbjct: 932 NKWIRKQCGIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIM 991
Query: 715 GVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXX--------XXXXXXXXQIIEAFGGTD 766
G+ DRH DNL++ DGK+FH DFG+ILG+ +I + D
Sbjct: 992 GIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVIRSGKSVD 1051
Query: 767 SANYD--KFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFD 824
+++ KF++ C AY ++ N L ++LF LM ++P + + LK F
Sbjct: 1052 GNSHELQKFKTLCVEAYEVMWNNRDLFVSLFTLMLGMELPELSTKADLDHLK-KTLFCNG 1110
Query: 825 LSEEDATIHFQNLITTSVN 843
S+E+A F + + N
Sbjct: 1111 ESKEEARKFFAGIYEEAFN 1129
>ECU11g0450 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 1433
Score = 120 bits (302), Expect = 7e-27
Identities = 117/472 (24%), Positives = 204/472 (42%), Gaps = 66/472 (13%)
Query: 384 SVRSYAVNRLRKASDNELELYLLQLVQSVCFE-----CTSTLSDKSNSEFTIVNIENSNN 438
S+ S A RLR+ S NE+ Y+ QLVQ + ++ STL + + E+
Sbjct: 993 SLVSRAFERLRE-SKNEMLFYVPQLVQMLRYKKVFEMAFSTLKELAKDEYV--------- 1042
Query: 439 DQNYSGDIIDASQFLANSFDKNSVMISPLAEFLIRRAVKNFRLGNFFYWYLRSESERNTF 498
A Q + N K ++ + R AV N+ G F
Sbjct: 1043 ----------AHQLIWNL--KANLYVDG------RAAVNNYH-GTF-------------- 1069
Query: 499 LVHILESFKSRLPEHSKKTIDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMR 558
V +E +P+ S+ + + L K E+ ++ ++ ++ SR++
Sbjct: 1070 -VRCIEEIMKEMPDGSRDIFLKEEEFISSLTKISSELTPHLRSSKDEKRRRINEYLSRIK 1128
Query: 559 SLFKNKAITLPLDPDVIAVDVIPSSCKVFKS-SLSPLKITFLTAN-GQHYS---LMFKVG 613
+ I +P PD+ ++++ S + +S S P +F + G S L+FK G
Sbjct: 1129 L---HPGIYIPFYPDLKIIEIVNGSARALQSHSKVPFMASFRVQDPGGQISIKQLIFKSG 1185
Query: 614 DDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSILSVH- 672
DD QD L +QII + + + K N+D+ L PY ++AT G I IPN +
Sbjct: 1186 DDCRQDMLALQIISMFESIFKQANLDIFLYPYKVMATSSGTGIIEVIPNSKSRDQIGKEN 1245
Query: 673 -HGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGK 731
+ +L+Y + + + E +G + NF S AGY ++ Y L + DRH N++I G+
Sbjct: 1246 INNLLEYFEYKFGFK-ESEGYLTAIC-NFASSLAGYSLVGYFLNIKDRHNGNIMIDDQGR 1303
Query: 732 FFHADFGYILGYD--XXXXXXXXXXXXQIIEAFGGTDSANYDKFRSYCFVAYSILRRNAG 789
H DFGY+L +I E GGT ++ ++ + LRR +
Sbjct: 1304 MIHIDFGYMLEMSPGNLNIEAPLKLTKEIEELLGGTSGKGFEIYQELMVKGFLALRRRSK 1363
Query: 790 LIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNLITTS 841
++ + + S++P + AV + +F F+LS+++A +LI S
Sbjct: 1364 DLVMMVDSFVDSELPCYR---RNAVENFILRFRFELSDKNARRFVLSLIAES 1412
>YLR305c [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 1900
Score = 116 bits (290), Expect = 2e-25
Identities = 134/606 (22%), Positives = 240/606 (39%), Gaps = 90/606 (14%)
Query: 289 TDTEKYIKPDAKK--RDVLNAIIASPP-----------GTKLTDHEKGLIWKYRYYLSNN 335
T TEK D+ + D++ A A P K D GL+ K+ +
Sbjct: 1341 TPTEKIEGADSNELTSDIVEATFAKDPTLAINLLQRCYSKKAEDVLVGLVAKHALMCVGS 1400
Query: 336 KKALTKLLQSTNLSEESEIKEVLDLMDIWAEIDLDDTMELLGPQYT-NISVRSYAVNRLR 394
AL ++ ++LS + ++ L WA + ++ L P++ N + +++ L
Sbjct: 1401 PSALDLFIKGSHLSSKKDLHATL----YWAPVSPLKSINLFLPEWQGNSFILQFSIYSLE 1456
Query: 395 KASDNELELYLLQLVQSVCFECTSTLSDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLA 454
N Y+ Q+VQ + ++ T + + ++ + +S II LA
Sbjct: 1457 SQDVNLAFFYVPQIVQCLRYDKTGYVER--------LILDTAKISVLFSHQII--WNMLA 1506
Query: 455 NSFDKNSVM----ISPLAEFLIRRAVKNFRLGNFFYWYLRSESERNTFLVHILESFKSRL 510
N + + + I P + + R V +F S+S R+ +
Sbjct: 1507 NCYKDDEGIQEDEIKPTLDRIRERMVSSF-----------SQSHRDFY------------ 1543
Query: 511 PEHSKKTIDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITLPL 570
E + D+ + L+ + ++ K K+ H I M + + LP
Sbjct: 1544 -EREFEFFDEVTGISGKLKPYIKKSKAEKK----------HKIDEEMSKIEVKPDVYLPS 1592
Query: 571 DPDVIAVDVIPSSCKVFKS-SLSPLKITF---------LTANGQHY----SLMFKVGDDL 616
+PD + +D+ S K +S + +P TF LT + + +FKVGDD
Sbjct: 1593 NPDGVVIDIDRKSGKPLQSHAKAPFMATFKIKKDVKDPLTGKNKEVEKWQAAIFKVGDDC 1652
Query: 617 IQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSILSVH--HG 674
QD L +Q+I L + + +D+ + PY + AT G I +PN +L +G
Sbjct: 1653 RQDVLALQLISLFRTIWSSIGLDVYVFPYRVTATAPGCGVIDVLPNSVSRDMLGREAVNG 1712
Query: 675 ILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFH 734
+ +Y + +++ I+ +NFVKS AGY VI+Y+L DRH N++ G H
Sbjct: 1713 LYEYFTSKFGNESTIEFQN--ARNNFVKSLAGYSVISYLLQFKDRHNGNIMYDDQGHCLH 1770
Query: 735 ADFGYILGY---DXXXXXXXXXXXXQIIEAFGGT-DSANYDKFRSYCFVAYSILRRNAGL 790
DFG+I ++++ GG+ + Y F C AY R +
Sbjct: 1771 IDFGFIFDIVPGGIKFEAVPFKLTKEMVKVMGGSPQTPAYLDFEELCIKAYLAARPHVEA 1830
Query: 791 IINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNLITTSVNALIPLVI 850
II M S +P K + + +F ++ +A ++ + LI S ++
Sbjct: 1831 IIECVNPMLGSGLPCFK--GHKTIRNLRARFQPQKTDHEAALYMKALIRKSYESIFTKGY 1888
Query: 851 DHLHNL 856
D L
Sbjct: 1889 DEFQRL 1894
>SPBC577.06c [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 1877
Score = 106 bits (264), Expect = 2e-22
Identities = 90/325 (27%), Positives = 139/325 (42%), Gaps = 40/325 (12%)
Query: 553 ISSRMRSLFKNKAITLPLDPDVIAVDVIPSSCKVFKS-SLSPLKITF------------- 598
I M+ + + + LP +PD + V + S K +S + +P TF
Sbjct: 1536 IDEEMKKIKLDVGVYLPSNPDGVIVGIDRKSGKPLQSHAKAPFMATFKIRKEKLVDADPE 1595
Query: 599 -LTANG-----------QHY----SLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKL 642
L NG Q Y S +FKVGDD QD L +Q+I + + + +D+ L
Sbjct: 1596 ELAVNGTEEEAGDSAKKQTYEVWQSAIFKVGDDCRQDVLTLQLIAMFKNIFNSVGLDVYL 1655
Query: 643 TPYNILATGKNEGAIGFIPNETMSSILSVH--HGILKYLQQNYPSQAEIDGVEPWVMDNF 700
PY + AT G I +PN +L +G+ Y + + + I + NF
Sbjct: 1656 FPYRVTATNPGCGVIDVLPNCISRDMLGREAVNGLYDYFRTKFGDEDSIAFQK--ARSNF 1713
Query: 701 VKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGY---DXXXXXXXXXXXXQ 757
V+S A Y VITY+L DRH N++I G H DFG+I +
Sbjct: 1714 VQSMAAYSVITYLLQFKDRHNGNIMIDDQGHILHIDFGFIFDIAPGGITFESAPFKLTTE 1773
Query: 758 IIEAFGGTD-SANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLK 816
+I GG++ S + F+ C A+ R A I E+M S +P K + +
Sbjct: 1774 MIAVMGGSNKSQPFQWFQELCVKAFLACRPYAHYICQAVEVMLDSGLPCFK--GQLTITH 1831
Query: 817 VMEKFAFDLSEEDATIHFQNLITTS 841
+E+FA +L+E A+ +LI S
Sbjct: 1832 CLERFALNLNERQASTFMLHLIEQS 1856
>At1g49340 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 1957
Score = 105 bits (262), Expect = 3e-22
Identities = 124/552 (22%), Positives = 216/552 (38%), Gaps = 87/552 (15%)
Query: 337 KALTKLLQSTNLSEESEIKEVLDLMDIWAEIDLDDTMELLGPQYT-NISVRSYAVNRLRK 395
+AL + N+ E S + L + WA + +E L P Y + V +Y + L
Sbjct: 1459 EALPYFVTPKNVEENSVL---LQQLPHWAACSITQALEFLTPAYKGHPRVMAYVLRVLES 1515
Query: 396 ASDNELELYLLQLVQSVCFECTSTLSDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLAN 455
+ ++ QLVQS+ ++ G +++
Sbjct: 1516 YPPERVTFFMPQLVQSLRYD---------------------------DGRLVEG------ 1542
Query: 456 SFDKNSVMISPLAEFLIRRAVKNFRLGNFFYWYLRSESERNTFLVHILE---SFKSRLPE 512
+L+R ++ + W+L+ E + T ++ +F+ LP+
Sbjct: 1543 --------------YLLRATQRSDIFAHILIWHLQGEDVQETPKDGSIDKNAAFQEILPQ 1588
Query: 513 HSKKTIDDQILLVDMLRKFCEEIKQSKETT--------VKKQEILLHLISSRMRSLFKNK 564
+ ID + L F E + T + K+E + + +
Sbjct: 1589 VRQHIIDG--FSPNALDMFTREFDFFDKVTSISGVLFPLPKEERRAGIRRELEKIEMQGD 1646
Query: 565 AITLPLDPDVIAVDV-IPSSCKVFKSSLSPLKITF--LTANGQHYSL-----MFKVGDDL 616
+ LP P+ + + + S + ++ P+ ITF + +G H + +FKVGDD
Sbjct: 1647 DLYLPTAPNKLVRGIRVDSGIPLQSAAKVPIMITFNVIDRDGDHSDVKPQACIFKVGDDC 1706
Query: 617 IQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSIL--SVHHG 674
QD L +Q+I L+ + + ++L L PY +L TG G I +PN S + + G
Sbjct: 1707 RQDVLALQVISLLRDIFQAAGLNLYLFPYGVLPTGAERGIIEVVPNTRSRSQMGETTDGG 1766
Query: 675 ILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFH 734
+ + QQ+Y +NF+ S AGY V + +L DRH NLL G+ H
Sbjct: 1767 LYEIFQQDYGPVGST--TFETARENFLISSAGYAVASLLLQPKDRHNGNLLFDDVGRLVH 1824
Query: 735 ADFGYILGYD-------XXXXXXXXXXXXQIIEAFGGTDSANYDKFRSYCFVAYSILRRN 787
DFG+IL Q+++ G S + +F S C Y RR
Sbjct: 1825 IDFGFILETSPGGNMRFESAHFKLSHEMTQLLDPSGVMKSKTWHQFVSLCVKGYLAARRQ 1884
Query: 788 AGLIINLFELMKTSDIPNI-KMDPEGAVLKVMEKFAFDLSEEDATIHFQNLITTSVNALI 846
II+ ++M S +P + DP G + K +F ++SE +A ++ T + N
Sbjct: 1885 MDGIISTVQMMLESGLPCFSRGDPIGNLRK---RFHPEMSEREAAHFMIHVCTDAYNKWT 1941
Query: 847 PLVIDHLHNLAQ 858
D + L Q
Sbjct: 1942 TAGYDLIQYLQQ 1953
>Hs4505809 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in
intracellular trafficking and secretion
Length = 828
Score = 101 bits (252), Expect = 4e-21
Identities = 66/264 (25%), Positives = 123/264 (46%), Gaps = 26/264 (9%)
Query: 602 NGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIP 661
N + S++ K GDDL Q+ L Q++K + + + E V L + PY IL + G I
Sbjct: 567 NWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMI---- 622
Query: 662 NETMSSILSVHH-------GILKYLQQ---NYPSQAEIDGVEPWVMDNFVKSCAGYCVIT 711
E + + +S+H +L Y Q +Y ++A + NFV+SCAGYC++
Sbjct: 623 -EPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQR-----NFVQSCAGYCLVC 676
Query: 712 YILGVGDRHLDNLLIQPDGKFFHADFGYILG---YDXXXXXXXXXXXXQIIEAFGGTDSA 768
Y+L V DRH N+L+ +G H DFG+IL + + ++ GG D
Sbjct: 677 YLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGD 736
Query: 769 NYDKFRSYCFVAYSILRRNAGLIINLFELMKT-SDIPNIKMDPEGAVLKVMEKFAFDLSE 827
++ ++ R++ ++ + E+M+ S +P + + E+F ++E
Sbjct: 737 MFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLP--CFHGSSTIRNLKERFHMSMTE 794
Query: 828 EDATIHFQNLITTSVNALIPLVID 851
E + + ++ S+ ++ + D
Sbjct: 795 EQLQLLVEQMVDGSMRSITTKLYD 818
>CE23035 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 2121
Score = 101 bits (251), Expect = 6e-21
Identities = 124/545 (22%), Positives = 225/545 (40%), Gaps = 105/545 (19%)
Query: 348 LSEESEIKEVLDLMDI--WAEIDLDDTMELLGPQYTNISVRS--YAVNRLRKASDNELEL 403
L S + E D+ + WA + LL P+ + S YAV LR S +EL L
Sbjct: 1606 LGNGSTVFETSDMSHVLTWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELLL 1665
Query: 404 YLLQLVQSVCFECTSTLSDKSNSEFTIVNIENSNNDQNYSGDIIDASQFLANSF-DKNSV 462
Y+ Q+VQ+V ++ +S+ + I + + Q S +I Q N F D+ S
Sbjct: 1666 YIPQIVQAVRYDTMGYISE--------LIIWLAGHSQLLSHQLIWNMQ--TNMFTDEESK 1715
Query: 463 MISPLAEFLIRRAVKNFRLGNFFYWYLRSESERNTFLVHILESFKSRLPEHSKKTIDDQI 522
+ P+ F N I++ S+L +++ + +
Sbjct: 1716 VKDPVL----------FEALN-----------------DIMQKILSQLEGAARRFHEAEF 1748
Query: 523 LLVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITLPLDPDVIAVDVIPS 582
L L IK + +K+ L L ++ ++ LP +P+ + +D+ S
Sbjct: 1749 KLFHQLTAISGTIKPFPKGDARKKACLKALADVKIETI-----TYLPSNPEAVLLDLDYS 1803
Query: 583 S---------------CKVFKSSLSPLKITFLTANGQH---------------------- 605
S +V + + L+ L A +H
Sbjct: 1804 SGTPMQSAAKAPFLARFRVKRCGVRELEHIGLQAQSEHGGKTTEADLEELKKVQDSRVCW 1863
Query: 606 YSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETM 665
+ +FKVGDD+ QD L +Q+++LM + + +++ PY ++AT G I +PN
Sbjct: 1864 QAAIFKVGDDVRQDMLALQLMQLMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSKS 1923
Query: 666 SSILS--VHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDN 723
L G+ +Y + Y ++ E NFV+S A Y V +++L + DRH N
Sbjct: 1924 RDQLGRQTDFGLYEYFKTQYGDESSETFQE--ARRNFVRSMAAYSVFSFLLQIKDRHNGN 1981
Query: 724 LLIQPDGKFFHADFGYI--------LGYDXXXXXXXXXXXXQIIEAFGG-TDSANYDKFR 774
++I DG H DFG++ LG++ +++ GG ++A + +F
Sbjct: 1982 IMIDLDGHIIHIDFGFMFESSPGGNLGFE-----PDFKLSEEMVAIMGGKMEAAPFRQFA 2036
Query: 775 SYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHF 834
S C AY +R ++L LM + +P + + ++ +FA +++E+DA +
Sbjct: 2037 SLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFR---GKTINQLRARFAPEMNEKDAAKYM 2093
Query: 835 QNLIT 839
++IT
Sbjct: 2094 YSVIT 2098
>7290340 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 2113
Score = 98.6 bits (244), Expect = 4e-20
Identities = 67/240 (27%), Positives = 110/240 (44%), Gaps = 13/240 (5%)
Query: 609 MFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSSI 668
+FKVGDD+ QD L +Q+I + + + +DL L PY ++AT G I +PN
Sbjct: 1859 IFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQ 1918
Query: 669 LS--VHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLLI 726
L G+ +Y Q Y ++ + NFVKS A Y +I Y+L + DRH N++I
Sbjct: 1919 LGRQTDSGLSEYFQHQYGDESSKEFQA--ARANFVKSMAAYSLIGYLLQIKDRHNGNIMI 1976
Query: 727 QPDGKFFHADFGYIL----GYDXXXXXXXXXXXXQIIEAFGGTDSANYDKFRSYCFVAYS 782
DG H DFG++ G + ++ G DS + F C A+
Sbjct: 1977 DKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFL 2036
Query: 783 ILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVM-EKFAFDLSEEDATIHFQNLITTS 841
+R I++L LM + +P + G + ++ ++F + ++A H +I S
Sbjct: 2037 AVRPYQDAIVSLVSLMLDTGLPCFR----GQTINLLKQRFVATKNNKEAAAHMLAVIRNS 2092
>YNL267w [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1066
Score = 98.2 bits (243), Expect = 5e-20
Identities = 76/277 (27%), Positives = 124/277 (44%), Gaps = 31/277 (11%)
Query: 607 SLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMS 666
S++ K GDDL Q+ Q+I+ M + E VD+ + IL T N G + ET++
Sbjct: 792 SVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLV-----ETIT 846
Query: 667 SILSVHHGILKYLQQNYPSQAEID---GVEPW------------------VMDNFVKSCA 705
+ +SVH I K L + AE+D G+ DNF S A
Sbjct: 847 NAMSVH-SIKKALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLA 905
Query: 706 GYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXXXXXXX---XXXQIIEAF 762
Y VI Y+L V DRH N++I +G H DFG++L + IE
Sbjct: 906 AYSVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELL 965
Query: 763 GGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFA 822
GG + + KF ++ LR+ A I+++ E+M+ ++ E +++ ++F
Sbjct: 966 GGVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQ 1025
Query: 823 FDLSEEDATIHFQN-LITTSVNALIPLVIDHLHNLAQ 858
DLSE++ +N LI S+ ++ + D + Q
Sbjct: 1026 LDLSEKEVDDFVENFLIGKSLGSIYTRIYDQFQLITQ 1062
>At1g51040 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 525
Score = 97.1 bits (240), Expect = 1e-19
Identities = 109/447 (24%), Positives = 184/447 (40%), Gaps = 45/447 (10%)
Query: 442 YSGDIIDASQFLANSFDKNSVMISPLAE-FLIRRAVKNFRLGNFFYWYLRSESERNTFLV 500
YS + S F + S + + E +L+R A ++ + W+L+ ES
Sbjct: 90 YSLSLESISAFYCSFLGYVSCLSQLMVEGYLLRAAQRSDIFAHTLIWHLQGESVEEIVKD 149
Query: 501 HILE---SFKSRLPEHSKKTIDDQILLVDMLRKFCEEIKQSKETT--------VKKQEIL 549
+ SF+ L + + +D L F E ++ T + K+E +
Sbjct: 150 GAFDKNASFQEILSDVRQHIVDG--FTPKALNFFSREFDFFEKVTSISGALLPLPKEERV 207
Query: 550 LHLISSRMRSLFKNKAITLPLDPD-VIAVDVIPSSCKVFKSSLSPLKITF--LTANGQHY 606
+ + + + + LP P+ ++ V + S + ++ P+ ITF + +G H
Sbjct: 208 AGIRRELEKIKMQGEDLYLPTAPNKLVRVIQVDSGIPLQSAAKVPIMITFNVVDLDGDHN 267
Query: 607 SL-----MFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIP 661
+ +FKVGDD QD L +Q+I L+ + + ++L L PY +L T +P
Sbjct: 268 DVKPQACIFKVGDDCRQDVLALQVISLLGDIFQAVGLNLYLFPYGVLPT--------VVP 319
Query: 662 NETMSSIL--SVHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDR 719
N S + + G+ + QQNY NF+ S AGY V + +L DR
Sbjct: 320 NTRSRSQMGETTDGGLYEIFQQNYGLVGST--TFETARANFLISSAGYAVASLLLQPKDR 377
Query: 720 HLDNLLIQPDGKFFHADFGYILGYD-------XXXXXXXXXXXXQIIEAFGGTDSANYDK 772
H NLL G+ H DFG+IL Q+++ G S + +
Sbjct: 378 HNGNLLFDDVGRLVHIDFGFILETSPGGNMRFENAHFKLSHEMTQLLDPSGVMKSKTWHQ 437
Query: 773 FRSYCFVAYSILRRNAGLIINLFELMKTSDIPNI-KMDPEGAVLKVMEKFAFDLSEEDAT 831
F S C Y RR II+ ++M S +P + DP G + K +F ++SE +A
Sbjct: 438 FVSLCVKGYLAARRYMDEIISTVQMMLESGLPCFSRGDPIGNLRK---RFHPEMSEREAA 494
Query: 832 IHFQNLITTSVNALIPLVIDHLHNLAQ 858
+ N+ T + N D + L Q
Sbjct: 495 LFMINVCTDAYNKWTTAGYDLIQYLQQ 521
>At5g64070 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1121
Score = 95.5 bits (236), Expect = 3e-19
Identities = 70/246 (28%), Positives = 111/246 (44%), Gaps = 9/246 (3%)
Query: 607 SLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNE-TM 665
S++ K GDD Q+ L VQ+I + + + L L PY +L T I IP+ ++
Sbjct: 860 SIIVKSGDDCRQEHLAVQLISHFYDIFQEAGLPLWLRPYEVLVTSSYTALIETIPDTASI 919
Query: 666 SSILSVHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILGVGDRHLDNLL 725
SI S + I E NFV+S AGY ++ Y+L V DRH NLL
Sbjct: 920 HSIKSRYPNITSLRDFFVAKYKENSPSFKLAQRNFVESMAGYSLVCYLLQVKDRHNGNLL 979
Query: 726 IQPDGKFFHADFGYILGYD---XXXXXXXXXXXXQIIEAF----GGTDSANYDKFRSYCF 778
+ +G H DFG++L +++E G S +D F+ C
Sbjct: 980 LDEEGHIIHIDFGFMLSNSPGGVNFESAPFKLTRELLEVMDSDADGVPSEFFDYFKVLCI 1039
Query: 779 VAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNLI 838
+ R++A II L E+++ S P K P + + ++F L+EE +LI
Sbjct: 1040 QGFLTCRKHAERIILLVEMLQDSGFPCFKGGPR-TIQNLRKRFHLSLTEEQCVSLVLSLI 1098
Query: 839 TTSVNA 844
++S++A
Sbjct: 1099 SSSLDA 1104
>At5g09350 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1116
Score = 93.6 bits (231), Expect = 1e-18
Identities = 65/246 (26%), Positives = 113/246 (45%), Gaps = 9/246 (3%)
Query: 607 SLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMS 666
S++ K GDD Q+ L VQ+I + + + L L PY +L T I IP+
Sbjct: 855 SIIVKSGDDCRQEHLAVQLISHFFDIFQEAGLPLWLRPYEVLVTSSYTALIETIPDTASI 914
Query: 667 SILSVHHGILKYLQQNYPSQAEIDGVE-PWVMDNFVKSCAGYCVITYILGVGDRHLDNLL 725
+ + + L+ + ++ + + NFV+S AGY ++ Y+L + DRH NLL
Sbjct: 915 HSIKSRYPNITSLRDFFDAKFKENSPSFKLAQRNFVESMAGYSLVCYLLQIKDRHNGNLL 974
Query: 726 IQPDGKFFHADFGYILGYD---XXXXXXXXXXXXQIIEAFG----GTDSANYDKFRSYCF 778
+ +G H DFG++L +++E G S +D F+ C
Sbjct: 975 MDEEGHIIHIDFGFMLSNSPGGVNFESAPFKLTRELLEVMDSDAEGLPSEFFDYFKVLCI 1034
Query: 779 VAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHFQNLI 838
+ R++A II L E+++ S P K P + + ++F L+EE +LI
Sbjct: 1035 QGFLTCRKHAERIILLVEMLQDSGFPCFKGGPR-TIQNLRKRFHLSLTEEQCVSLVLSLI 1093
Query: 839 TTSVNA 844
++S++A
Sbjct: 1094 SSSLDA 1099
>ECU10g0590 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 458
Score = 88.6 bits (218), Expect = 4e-17
Identities = 76/344 (22%), Positives = 147/344 (42%), Gaps = 13/344 (3%)
Query: 518 IDDQILLVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITLPLDPDVIAV 577
++ Q+ LVD +R+ Q + +E LH + D
Sbjct: 127 LEGQMALVDEIRRIYSITSQGSPRKKRLREYRLHGTLCLHPGAGSMRLYASLFSLDATVK 186
Query: 578 DVIPSSCKVFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNEN 637
++I ++F SS P+ + T G +++K GDDL +D V++ I+ M +L+
Sbjct: 187 EIIFPEIEIFPSSTFPILVPLRTDRGVS-RIIYKKGDDLTRDLFVLETIRYMSRLM---- 241
Query: 638 VDLKLTPYNILATGKNEGAIGFIPNETMSSILSVHHGILKYLQQNYPSQAEIDGVEPWVM 697
+ L Y ++ + EG + + + I S + Y++++ + + + V
Sbjct: 242 -GVDLVTYKVIPLSRKEGIVEVVDGIDFTRIRS-RKDLEMYIEEDRDPRHQESFEKRKV- 298
Query: 698 DNFVKSCAGYCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXXXXXXXXXXQ 757
FV + GY V Y++G+GDR+ N+++ DGKFFH DF ++ G D
Sbjct: 299 --FVSTLCGYSVACYVMGIGDRNPGNMMVTRDGKFFHIDFSHVFGRDPKPISSRITIARP 356
Query: 758 IIEAFGGTDSANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKV 817
I + + D Y F + A+ +RR+ I L+ ++ + I + D +
Sbjct: 357 IRD-YLVNDELIYQDFLARSGEAFLQIRRSCRKIFVLWCILAQNRI--FQFDLNEIIPFA 413
Query: 818 MEKFAFDLSEEDATIHFQNLITTSVNALIPLVIDHLHNLAQYWR 861
+ ++SE+ A F+ I +V +L V ++ + + R
Sbjct: 414 QARLRMEMSEQRALELFEKEIRGAVGSLKTSVAHLINRVGMFLR 457
>Hs4505807 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 854
Score = 86.7 bits (213), Expect = 1e-16
Identities = 63/248 (25%), Positives = 115/248 (45%), Gaps = 16/248 (6%)
Query: 601 ANGQHYS---LMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAI 657
A+GQ S +FKVGDD QD L +QII L + + +DL + PY ++AT G I
Sbjct: 589 ADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVI 648
Query: 658 GFIPNETMSSIL--SVHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILG 715
IP+ T L G+ Y + Y ++ + + NF++S A Y ++ ++L
Sbjct: 649 ECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQ--ARYNFIRSMAAYSLLLFLLQ 706
Query: 716 VGDRHLDNLLIQPDGKFFHADFGYIL----GYDXXXXXXXXXXXXQIIEAFGGTDSANYD 771
+ DRH N+++ G H DFG++ G + ++ G ++ +
Sbjct: 707 IKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFK 766
Query: 772 KFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVME-KFAFDLSEEDA 830
F C Y +R +++L LM + +P + G +K+++ +F+ +++E +A
Sbjct: 767 WFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFR----GQTIKLLKHRFSPNMTEREA 822
Query: 831 TIHFQNLI 838
+I
Sbjct: 823 ANFIMKVI 830
>Hs17105400 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 2044
Score = 86.7 bits (213), Expect = 1e-16
Identities = 63/248 (25%), Positives = 115/248 (45%), Gaps = 16/248 (6%)
Query: 601 ANGQHYS---LMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAI 657
A+GQ S +FKVGDD QD L +QII L + + +DL + PY ++AT G I
Sbjct: 1779 ADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVI 1838
Query: 658 GFIPNETMSSIL--SVHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILG 715
IP+ T L G+ Y + Y ++ + + NF++S A Y ++ ++L
Sbjct: 1839 ECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQ--ARYNFIRSMAAYSLLLFLLQ 1896
Query: 716 VGDRHLDNLLIQPDGKFFHADFGYIL----GYDXXXXXXXXXXXXQIIEAFGGTDSANYD 771
+ DRH N+++ G H DFG++ G + ++ G ++ +
Sbjct: 1897 IKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFK 1956
Query: 772 KFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVME-KFAFDLSEEDA 830
F C Y +R +++L LM + +P + G +K+++ +F+ +++E +A
Sbjct: 1957 WFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFR----GQTIKLLKHRFSPNMTEREA 2012
Query: 831 TIHFQNLI 838
+I
Sbjct: 2013 ANFIMKVI 2020
>Hs4826730 [L] KOG0891 DNA-dependent protein kinase
Length = 2549
Score = 77.4 bits (189), Expect = 9e-14
Identities = 66/263 (25%), Positives = 116/263 (44%), Gaps = 53/263 (20%)
Query: 523 LLVDMLRKFCEEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITLPLDPD--VIAVDVI 580
L + R+ +++ Q T+++ Q + L+ R L A+ DP+ +I + I
Sbjct: 2103 LYYHVFRRISKQLPQL--TSLELQYVSPKLLMCRDLEL----AVPGTYDPNQPIIRIQSI 2156
Query: 581 PSSCKVFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDL 640
S +V S P K+T + +NG + + K +DL QD+ V+Q+ L++ LL N+ L
Sbjct: 2157 APSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSL 2216
Query: 641 K----LTPYNILATGKNEGAIGFIPN------------ETMSSILSVHHGILKYLQQNYP 684
+ + Y ++ N G IG++P+ E +L++ H I+ + +Y
Sbjct: 2217 RKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYD 2276
Query: 685 SQAEIDGVEP-----------------WVMD-----------NFVKSCAGYCVITYILGV 716
+ VE W+ N+ +S A ++ YILG+
Sbjct: 2277 HLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGL 2336
Query: 717 GDRHLDNLLI-QPDGKFFHADFG 738
GDRH NL++ + GK H DFG
Sbjct: 2337 GDRHPSNLMLDRLSGKILHIDFG 2359
>Hs22068531 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 523
Score = 77.4 bits (189), Expect = 9e-14
Identities = 46/145 (31%), Positives = 75/145 (51%), Gaps = 7/145 (4%)
Query: 601 ANGQHYS---LMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAI 657
A+GQ S +FK+GDD QD L +QII L + + +DL + PY ++AT G I
Sbjct: 304 ADGQKISWQAAIFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVI 363
Query: 658 GFIPNETMSSIL--SVHHGILKYLQQNYPSQAEIDGVEPWVMDNFVKSCAGYCVITYILG 715
IP+ T L G+ Y + Y ++ + + NF++S A Y ++ ++L
Sbjct: 364 ECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQ--ARYNFIRSMAAYSLLLFLLQ 421
Query: 716 VGDRHLDNLLIQPDGKFFHADFGYI 740
+ DRH N+++ G H DFG++
Sbjct: 422 IKDRHNGNIMLDKKGHIIHIDFGFM 446
>CE04513 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in
intracellular trafficking and secretion
Length = 604
Score = 76.6 bits (187), Expect = 1e-13
Identities = 57/211 (27%), Positives = 92/211 (43%), Gaps = 26/211 (12%)
Query: 608 LMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMSS 667
++ K GDDL Q+ Q++ L E V L L PY I+ G + G I E +
Sbjct: 337 VIVKTGDDLSQEAFAQQLLFTFKDLWHEEGVPLYLRPYKIVCIGSDAGLI-----EPVLD 391
Query: 668 ILSVHHGILKYLQQNYPSQAEID---------------GVEPWV--MDNFVKSCAGYCVI 710
LS+H I ++L + + E +V NF++S A Y ++
Sbjct: 392 TLSLHQ-IKRHLTNVFRMNGNVTTPSLKHHFENVFGPVNSETYVNAQKNFIQSTAAYSLV 450
Query: 711 TYILGVGDRHLDNLLIQPDGKFFHADFGYILG---YDXXXXXXXXXXXXQIIEAFGGTDS 767
+Y L + DRH N+L+ DG H D+G++L + +II+ GG DS
Sbjct: 451 SYYLQLKDRHNGNILLDMDGHLIHIDYGFLLSSSPRNLGFETAPFKLTTEIIDVMGGIDS 510
Query: 768 ANYDKFRSYCFVAYSILRRNAGLIINLFELM 798
+ F+S R++ I++L E+M
Sbjct: 511 DMFLYFKSLLLRGLMAARKHHRRIVSLAEIM 541
>At1g50030 [L] KOG0891 DNA-dependent protein kinase
Length = 2467
Score = 76.3 bits (186), Expect = 2e-13
Identities = 57/191 (29%), Positives = 94/191 (48%), Gaps = 21/191 (10%)
Query: 567 TLPLDPDVIAVDVIPSSCKVFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQII 626
T D V+ + V S P K+T +G+ Y+ + K +DL QD+ V+Q+
Sbjct: 2057 TYRADAPVVTISSFSRQLVVITSKQRPRKLTIHGNDGEDYAFLLKGHEDLRQDERVMQLF 2116
Query: 627 KLMDQLLKNE----NVDLKLTPYNILATGKNEGAIGFIPN-ETMSSILSVHHGILKYL-- 679
L++ LL+N DL + Y+++ N G IG++PN +T+ ++ H K +
Sbjct: 2117 GLVNTLLENSRKTAEKDLSIQRYSVIPLSPNSGLIGWVPNCDTLHHLIREHRDARKIILN 2176
Query: 680 QQN---------YPSQAEIDGVEPWVMDNFVKSCAGYCV--ITYILGVGDRHLDNLLI-Q 727
Q+N Y + I VE V + +++ G + + YILG+GDRH NL++ +
Sbjct: 2177 QENKHMLSFAPDYDNLPLIAKVE--VFEYALENTEGNDLSRVGYILGLGDRHPSNLMLHR 2234
Query: 728 PDGKFFHADFG 738
GK H DFG
Sbjct: 2235 YSGKILHIDFG 2245
>SPAC22E12.16c [TU] KOG0903 Phosphatidylinositol 4-kinase involved in
intracellular trafficking and secretion
Length = 851
Score = 74.7 bits (182), Expect = 6e-13
Identities = 62/260 (23%), Positives = 109/260 (41%), Gaps = 24/260 (9%)
Query: 607 SLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMS 666
S++ K G DL Q+ Q+I ++ + + IL TG N G I I N
Sbjct: 580 SVIVKTGADLRQETFACQLIYAFQRVWLECKEKVWVRRMKILVTGDNSGLIETITNAI-- 637
Query: 667 SILSVHHGILKYLQQNYPSQAEIDGVEPWVMD--------------------NFVKSCAG 706
S+ S+ + K L++ +Q +I G + NF++S
Sbjct: 638 SVHSIKKNLTKQLREAELAQGKIAGKNVVTLKDYFIKQFGDPNSSRYRQAQTNFLQSLVA 697
Query: 707 YCVITYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXXXXXXXXXXQIIEAFGGTD 766
Y +I+Y+L + DRH N+LI +G H DFG++L + D
Sbjct: 698 YSIISYLLQLKDRHNGNVLIDSEGHIIHIDFGFLLTNTPGNVGFESAPFKLTADYLEILD 757
Query: 767 SANYDKFRSYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLS 826
+D++RS A+ +R+NA II L E+M+ + E +++++F L
Sbjct: 758 D-RFDEYRSLMKAAFKSVRKNADQIILLVEVMQNNSTMPCFRAGENTSAQLLQRFQLQLG 816
Query: 827 EEDATIHFQNLITTSVNALI 846
+++ F +L+ N +
Sbjct: 817 DKECD-DFVDLLIQKANCSV 835
>ECU03g1100 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in
intracellular trafficking and secretion
Length = 711
Score = 73.9 bits (180), Expect = 1e-12
Identities = 58/251 (23%), Positives = 107/251 (42%), Gaps = 23/251 (9%)
Query: 607 SLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLKLTPYNILATGKNEGAIGFIPNETMS 666
S++ K G+ L+Q+ + Q++ M ++ + E + + Y I G + ET+
Sbjct: 456 SVIVKTGNSLMQELMAYQVLCEMKRIWREEGSPIWIRAYQIYLISDTSGIV-----ETVV 510
Query: 667 SILSVHHGILKYLQQN--------YPSQAEIDGVE-PWVMDNFVKSCAGYCVITYILGVG 717
+S+H K + +N + E++ + + NF+ S GY + TYIL V
Sbjct: 511 DAMSIHKIKKKMMSENKNYSLRNYFADSFELNSAKYKSCLRNFLYSLVGYSLATYILQVK 570
Query: 718 DRHLDNLLIQPDGKFFHADFGYILGYD---XXXXXXXXXXXXQIIEAFGGTDSANYDKFR 774
DRH N++I G H DFG+++G + +E G D+F+
Sbjct: 571 DRHNGNIMIDGQGHIVHVDFGFVMGGHPGFYCVEAAPFKFSKEYLELLGDL----VDEFK 626
Query: 775 SYCFVAYSILRRNAGLIINLFELMKTSDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHF 834
Y LR+++ + + E M + + + + ++F DL+EE H
Sbjct: 627 DLFLRGYMELRKHSSRLFRIIETMPGAS--GAECFNKRELQNFKDRFRLDLTEERVEEHV 684
Query: 835 QNLITTSVNAL 845
LI S N++
Sbjct: 685 LYLINKSFNSM 695
>CE28813 [L] KOG0891 DNA-dependent protein kinase
Length = 687
Score = 72.4 bits (176), Expect = 3e-12
Identities = 66/258 (25%), Positives = 114/258 (43%), Gaps = 51/258 (19%)
Query: 531 FCEEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITLP--LDPD--VIAVDVIPSSCKV 586
+C K+ ++ + L +S + S K+ + +P DP ++++ S V
Sbjct: 270 YCSVFKKLRDQLATLNSLDLVYVSPNLVSA-KDLELVVPGTYDPSAPIVSIQSFSSKMNV 328
Query: 587 FKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENV----DLKL 642
S P K+ +NG Y + K +D QD+ V+Q+ L++ LL N + +L +
Sbjct: 329 ITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTI 388
Query: 643 TPYNILATGKNEGAIGFIPN-ETMSSI------------LSVHHGILKYLQ--------- 680
Y+I+A K+ G IG++PN +T+ ++ LS+ H L+ L
Sbjct: 389 QRYSIVALSKDSGLIGWVPNCDTLHTLVKEYREKKAKIPLSIEHKTLQKLSLETEHLTLM 448
Query: 681 ---QNYPSQAEIDGVEP-----WVMD-----------NFVKSCAGYCVITYILGVGDRHL 721
Q + S + E W+ N+ +S A ++ YILG+GDRH
Sbjct: 449 QKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRHP 508
Query: 722 DNLLI-QPDGKFFHADFG 738
NL++ + GK H DFG
Sbjct: 509 SNLMLDRLTGKVVHIDFG 526
>CE07705 [L] KOG0891 DNA-dependent protein kinase
Length = 2697
Score = 72.4 bits (176), Expect = 3e-12
Identities = 66/258 (25%), Positives = 114/258 (43%), Gaps = 51/258 (19%)
Query: 531 FCEEIKQSKETTVKKQEILLHLISSRMRSLFKNKAITLP--LDPD--VIAVDVIPSSCKV 586
+C K+ ++ + L +S + S K+ + +P DP ++++ S V
Sbjct: 2280 YCSVFKKLRDQLATLNSLDLVYVSPNLVSA-KDLELVVPGTYDPSAPIVSIQSFSSKMNV 2338
Query: 587 FKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENV----DLKL 642
S P K+ +NG Y + K +D QD+ V+Q+ L++ LL N + +L +
Sbjct: 2339 ITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTI 2398
Query: 643 TPYNILATGKNEGAIGFIPN-ETMSSI------------LSVHHGILKYLQ--------- 680
Y+I+A K+ G IG++PN +T+ ++ LS+ H L+ L
Sbjct: 2399 QRYSIVALSKDSGLIGWVPNCDTLHTLVKEYREKKAKIPLSIEHKTLQKLSLETEHLTLM 2458
Query: 681 ---QNYPSQAEIDGVEP-----WVMD-----------NFVKSCAGYCVITYILGVGDRHL 721
Q + S + E W+ N+ +S A ++ YILG+GDRH
Sbjct: 2459 QKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRHP 2518
Query: 722 DNLLI-QPDGKFFHADFG 738
NL++ + GK H DFG
Sbjct: 2519 SNLMLDRLTGKVVHIDFG 2536
>7297995 [L] KOG0891 DNA-dependent protein kinase
Length = 2470
Score = 68.2 bits (165), Expect = 5e-11
Identities = 52/211 (24%), Positives = 96/211 (44%), Gaps = 45/211 (21%)
Query: 573 DVIAVDVIPSSCKVFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQL 632
++I + +I ++ +V S P K+ +NG+ Y + K +DL QD+ V+Q+ L++ L
Sbjct: 2070 ELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTL 2129
Query: 633 LKNE----NVDLKLTPYNILATGKNEGAIGFIPN-ETMSSI-----------LSVHHGIL 676
L ++ +L + Y ++ N G IG++P+ +T+ ++ L+ H +
Sbjct: 2130 LLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTM 2189
Query: 677 KYLQQNYPSQAEIDGVEP-----------------WV-----------MDNFVKSCAGYC 708
+Y + VE W+ +N+ +S A
Sbjct: 2190 LNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMS 2249
Query: 709 VITYILGVGDRHLDNLLI-QPDGKFFHADFG 738
++ YILG+GDRH NL++ + GK H DFG
Sbjct: 2250 MVGYILGLGDRHPSNLMLDRMSGKILHIDFG 2280
>CE28250 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2514
Score = 67.8 bits (164), Expect = 7e-11
Identities = 69/281 (24%), Positives = 109/281 (38%), Gaps = 49/281 (17%)
Query: 572 PDVIAVDVIPSSCKVFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLM-D 630
PD + KV S+ P+ I T G+ L+ K DDL +D +++++ D
Sbjct: 2167 PDRYLIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFTKMVEMCND 2226
Query: 631 QLLKNENVDLK---LTPYNILATGKNEGAIGFIPN-----ETMSSILSVHHGI----LKY 678
L+K+E ++ T Y+++ GK G I F+ ET+ ++ + G LK+
Sbjct: 2227 LLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMGMTSGEWLEKLKF 2286
Query: 679 LQQNYPSQAEIDGVE----------PWVMDN------------------FVKSCAGYCVI 710
+ + + + P VM F KS A VI
Sbjct: 2287 WNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVI 2346
Query: 711 TYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXXXXXXXXXXQIIEAFGGTDSANY 770
YI G+GDRH NL++ GK H DF I G
Sbjct: 2347 GYIFGLGDRHTKNLMVHTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVAL 2406
Query: 771 D-KFRSYCFVAYSILRRNAGLIINLFELMK-TSDIPNIKMD 809
D +FR+ C A + R N+ +E+ K +D+PN+ D
Sbjct: 2407 DGEFRTVCEQALRVFRENS------YEIEKYIADLPNLVAD 2441
>CE25103 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2531
Score = 67.8 bits (164), Expect = 7e-11
Identities = 69/281 (24%), Positives = 109/281 (38%), Gaps = 49/281 (17%)
Query: 572 PDVIAVDVIPSSCKVFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLM-D 630
PD + KV S+ P+ I T G+ L+ K DDL +D +++++ D
Sbjct: 2184 PDRYLIHDFSDKVKVLHSNTKPVIIKLTTKTGRIVRLICKKDDDLSKDYHFTKMVEMCND 2243
Query: 631 QLLKNENVDLK---LTPYNILATGKNEGAIGFIPN-----ETMSSILSVHHGI----LKY 678
L+K+E ++ T Y+++ GK G I F+ ET+ ++ + G LK+
Sbjct: 2244 LLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLMGMTSGEWLEKLKF 2303
Query: 679 LQQNYPSQAEIDGVE----------PWVMDN------------------FVKSCAGYCVI 710
+ + + + P VM F KS A VI
Sbjct: 2304 WNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVI 2363
Query: 711 TYILGVGDRHLDNLLIQPDGKFFHADFGYILGYDXXXXXXXXXXXXQIIEAFGGTDSANY 770
YI G+GDRH NL++ GK H DF I G
Sbjct: 2364 GYIFGLGDRHTKNLMVHTTGKCIHVDFDMIFNKGETLGTPELVPFRLTQNMINGMGEVAL 2423
Query: 771 D-KFRSYCFVAYSILRRNAGLIINLFELMK-TSDIPNIKMD 809
D +FR+ C A + R N+ +E+ K +D+PN+ D
Sbjct: 2424 DGEFRTVCEQALRVFRENS------YEIEKYIADLPNLVAD 2458
>YBR136w [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2368
Score = 65.9 bits (159), Expect = 3e-10
Identities = 87/375 (23%), Positives = 159/375 (42%), Gaps = 71/375 (18%)
Query: 487 WYLRS-----ESERNTFLVHILESFKSRLPEHSKKTIDDQILLVDMLRKFC-EEIK---- 536
WY+ + S+R HILE ++ ++ + + L L + C +++K
Sbjct: 1936 WYITALVNSNSSKRVLRGKHILEKYRQH-SQNPHDLVSSALDLTKALTRVCLQDVKSITS 1994
Query: 537 QSKETTVKKQEILLHLISSRMR-SLFKNKAITLPLDPD----------VIAVDVIPSSCK 585
+S ++ K + +++ S M + KN I PL+ + V+++ SS K
Sbjct: 1995 RSGKSLEKDFKFDMNVAPSAMVVPVRKNLDIISPLESNSMRGYQPFRPVVSIIRFGSSYK 2054
Query: 586 VFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLK---- 641
VF S P ++ + ++G Y +M K +D+ QD +Q MD LL + K
Sbjct: 2055 VFSSLKKPKQLNIIGSDGNIYGIMCKK-EDVRQDNQYMQFATTMDFLLSKDIASRKRSLG 2113
Query: 642 LTPYNILATGKNEGAIGFIPNE-TMSSILSVHHGILKY------LQQNYPSQA------- 687
+ Y++L+ ++ G + +PN T+ SILS + LK L + A
Sbjct: 2114 INIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLKIKYSLKSLHDRWQHTAVDGKLEF 2173
Query: 688 ---EIDGVEP----WVMDNF-------------VKSCAGYCVITYILGVGDRHLDNLLIQ 727
++D P W ++NF +S A ++ +ILG+GDRH +N+L+
Sbjct: 2174 YMEQVDKFPPILYQWFLENFPDPINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLD 2233
Query: 728 -PDGKFFHADFGYILGYDXXX---XXXXXXXXXQIIEAFG--GTDSANYDKFRSYCFVAY 781
GK H DF + +++A G GT+ F+ V
Sbjct: 2234 IQTGKVLHVDFDCLFEKGKRLPVPEIVPFRLTPNLLDALGIIGTEGT----FKKSSEVTL 2289
Query: 782 SILRRNAGLIINLFE 796
+++R+N ++N+ E
Sbjct: 2290 ALMRKNEVALMNVIE 2304
>YJR066w [L] KOG0891 DNA-dependent protein kinase
Length = 2470
Score = 63.9 bits (154), Expect = 1e-09
Identities = 48/198 (24%), Positives = 85/198 (42%), Gaps = 45/198 (22%)
Query: 586 VFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNENVDLK---- 641
V S P K + ++G+ Y + K +D+ QD LV+Q+ L++ LLKN++ K
Sbjct: 2099 VISSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLD 2158
Query: 642 LTPYNILATGKNEGAIGFIPNETMSSIL------------SVHHGILKYLQQNYPSQAEI 689
+ Y + G +G++PN +L ++ H ++ + +Y + +
Sbjct: 2159 IQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHRDAKKIPLNIEHWVMLQMAPDYENLTLL 2218
Query: 690 DGVE--PWVMDN--------------------------FVKSCAGYCVITYILGVGDRHL 721
+E + +DN + +S A + YILG+GDRH
Sbjct: 2219 QKIEVFTYALDNTKGQDLYKILWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHP 2278
Query: 722 DNLLI-QPDGKFFHADFG 738
NL++ + GK H DFG
Sbjct: 2279 SNLMLDRITGKVIHIDFG 2296
>YKL203c [L] KOG0891 DNA-dependent protein kinase
Length = 2473
Score = 59.7 bits (143), Expect = 2e-08
Identities = 48/198 (24%), Positives = 83/198 (41%), Gaps = 45/198 (22%)
Query: 586 VFKSSLSPLKITFLTANGQHYSLMFKVGDDLIQDQLVVQIIKLMDQLLKNE----NVDLK 641
V S P K ++G+ Y + K +D+ QD LV+Q+ L++ LL+N+ L
Sbjct: 2102 VISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLD 2161
Query: 642 LTPYNILATGKNEGAIGFIPN------------ETMSSILSVHHGILKYLQQNYPSQAEI 689
+ Y + G +G++PN E L++ H ++ + +Y + +
Sbjct: 2162 IQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQMAPDYDNLTLL 2221
Query: 690 DGVE--PWVMDN--------------------------FVKSCAGYCVITYILGVGDRHL 721
VE + ++N + +S A + YILG+GDRH
Sbjct: 2222 QKVEVFTYALNNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHP 2281
Query: 722 DNLLI-QPDGKFFHADFG 738
NL++ + GK H DFG
Sbjct: 2282 SNLMLDRITGKVIHIDFG 2299
>7291958 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1572
Score = 59.3 bits (142), Expect = 2e-08
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 4/137 (2%)
Query: 719 RHLDNLLIQPDGKFFHADFGYILGY---DXXXXXXXXXXXXQIIEAFGGTDSANYDKFRS 775
RH N+L DG H DFG+IL + + +E GGT S ++ +F
Sbjct: 1426 RHNGNILFHSDGHIIHIDFGFILSISPKNLGFEQSPFKLTPEFVEVMGGTSSEHWREFNK 1485
Query: 776 YCFVAYSILRRNAGLIINLFELMKT-SDIPNIKMDPEGAVLKVMEKFAFDLSEEDATIHF 834
V R++ IIN E+M++ + +P K G V + ++F +L+E++
Sbjct: 1486 LLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKV 1545
Query: 835 QNLITTSVNALIPLVID 851
+ L+ S+ +L + D
Sbjct: 1546 EQLVQDSLKSLSTKLYD 1562
>Hs20533633 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 297
Score = 50.8 bits (120), Expect = 9e-06
Identities = 19/30 (63%), Positives = 25/30 (83%)
Query: 698 DNFVKSCAGYCVITYILGVGDRHLDNLLIQ 727
+ F SCAGYCV TY+LG+GDRH DN++I+
Sbjct: 202 EEFTLSCAGYCVATYVLGIGDRHSDNIMIR 231
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,998,163
Number of Sequences: 60738
Number of extensions: 2157435
Number of successful extensions: 6476
Number of sequences better than 1.0e-05: 50
Number of HSP's better than 0.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 6289
Number of HSP's gapped (non-prelim): 102
length of query: 862
length of database: 30,389,216
effective HSP length: 115
effective length of query: 747
effective length of database: 23,404,346
effective search space: 17483046462
effective search space used: 17483046462
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)