ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV4696 good T KOG0789 Signal transduction mechanisms Protein tyrosine phosphatase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV4696 1605361 1604750 -204
(204 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDL230w [T] KOG0789 Protein tyrosine phosphatase 191 5e-49
SPAC26F1.10c [T] KOG0789 Protein tyrosine phosphatase 86 3e-17
SPAC19D5.01 [T] KOG0789 Protein tyrosine phosphatase 86 3e-17
SPAC11E3.09 [T] KOG0791 Protein tyrosine phosphatase contains fn... 84 1e-16
CE03335 [T] KOG0791 Protein tyrosine phosphatase contains fn3 do... 84 2e-16
7290546 [T] KOG0791 Protein tyrosine phosphatase contains fn3 do... 82 4e-16
Hs18104993 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 82 7e-16
Hs18104991 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 82 7e-16
Hs18104989 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 82 7e-16
7301780 [T] KOG0789 Protein tyrosine phosphatase 82 7e-16
Hs18104986 [T] KOG0792 Protein tyrosine phosphatase PTPMEG conta... 81 9e-16
7290264 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and r... 81 1e-15
7290263 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and r... 81 1e-15
Hs4506329 [T] KOG0789 Protein tyrosine phosphatase 80 1e-15
Hs18860900 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 80 1e-15
Hs18491010 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 80 1e-15
Hs18860898_2 [T] KOG0789 Protein tyrosine phosphatase 80 2e-15
CE06093 [T] KOG4228 Protein tyrosine phosphatase 80 3e-15
Hs5729993 [T] KOG4228 Protein tyrosine phosphatase 79 4e-15
Hs18860859 [T] KOG4228 Protein tyrosine phosphatase 79 4e-15
Hs18375660 [T] KOG0789 Protein tyrosine phosphatase 79 4e-15
Hs18375658 [T] KOG0789 Protein tyrosine phosphatase 79 4e-15
CE11200 [T] KOG0789 Protein tyrosine phosphatase 79 4e-15
CE15903 [T] KOG0789 Protein tyrosine phosphatase 79 6e-15
Hs18375642 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 78 7e-15
Hs4506325 [T] KOG0789 Protein tyrosine phosphatase 77 1e-14
Hs19743917 [T] KOG0789 Protein tyrosine phosphatase 77 1e-14
Hs18860902 [T] KOG4228 Protein tyrosine phosphatase 77 2e-14
CE24794 [T] KOG4228 Protein tyrosine phosphatase 76 3e-14
Hs4506291 [T] KOG0789 Protein tyrosine phosphatase 75 6e-14
Hs18104982 [T] KOG0789 Protein tyrosine phosphatase 75 6e-14
Hs18104980 [T] KOG0789 Protein tyrosine phosphatase 75 6e-14
CE29408 [T] KOG4228 Protein tyrosine phosphatase 75 6e-14
CE26369 [T] KOG4228 Protein tyrosine phosphatase 75 6e-14
Hs19743929 [T] KOG4228 Protein tyrosine phosphatase 75 8e-14
Hs19743927 [T] KOG4228 Protein tyrosine phosphatase 75 8e-14
Hs5453992 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contai... 74 1e-13
Hs18375650 [T] KOG0792 Protein tyrosine phosphatase PTPMEG conta... 74 1e-13
Hs18375648 [T] KOG0792 Protein tyrosine phosphatase PTPMEG conta... 74 1e-13
Hs18375646 [T] KOG0792 Protein tyrosine phosphatase PTPMEG conta... 74 1e-13
Hs18641364 [T] KOG4228 Protein tyrosine phosphatase 74 1e-13
Hs18641362 [T] KOG4228 Protein tyrosine phosphatase 74 1e-13
Hs18641347 [T] KOG4228 Protein tyrosine phosphatase 74 1e-13
Hs4506323 [T] KOG0791 Protein tyrosine phosphatase contains fn3 ... 74 2e-13
Hs18860904 [T] KOG4228 Protein tyrosine phosphatase 74 2e-13
Hs13677218 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 74 2e-13
Hs13677216 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 74 2e-13
Hs13677214 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 74 2e-13
CE09014 [T] KOG0789 Protein tyrosine phosphatase 74 2e-13
Hs4506289 [T] KOG0789 Protein tyrosine phosphatase 73 3e-13
Hs4506303 [T] KOG4228 Protein tyrosine phosphatase 72 4e-13
Hs18450369 [T] KOG4228 Protein tyrosine phosphatase 72 4e-13
Hs15619018 [T] KOG0789 Protein tyrosine phosphatase 72 5e-13
7292674 [T] KOG0791 Protein tyrosine phosphatase contains fn3 do... 71 9e-13
Hs7706280 [T] KOG0789 Protein tyrosine phosphatase 70 2e-12
Hs5902032 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contai... 70 2e-12
7294551 [T] KOG4228 Protein tyrosine phosphatase 70 2e-12
Hs19743935 [T] KOG4228 Protein tyrosine phosphatase 70 2e-12
Hs19743933 [T] KOG4228 Protein tyrosine phosphatase 70 2e-12
Hs19743931 [T] KOG4228 Protein tyrosine phosphatase 70 2e-12
CE28359 [T] KOG0789 Protein tyrosine phosphatase 70 2e-12
CE10626 [T] KOG0789 Protein tyrosine phosphatase 70 3e-12
CE10616 [T] KOG0789 Protein tyrosine phosphatase 70 3e-12
Hs4506309 [T] KOG4228 Protein tyrosine phosphatase 69 3e-12
Hs18860894 [T] KOG4228 Protein tyrosine phosphatase 69 3e-12
Hs18860892 [T] KOG4228 Protein tyrosine phosphatase 69 3e-12
Hs18860890 [T] KOG4228 Protein tyrosine phosphatase 69 3e-12
Hs22052020_2 [T] KOG0789 Protein tyrosine phosphatase 69 3e-12
Hs19743925 [T] KOG4228 Protein tyrosine phosphatase 69 6e-12
Hs19743923 [T] KOG4228 Protein tyrosine phosphatase 69 6e-12
Hs19743921 [T] KOG4228 Protein tyrosine phosphatase 69 6e-12
Hs19743919 [T] KOG4228 Protein tyrosine phosphatase 69 6e-12
CE20664 [T] KOG0789 Protein tyrosine phosphatase 68 1e-11
Hs18375652 [T] KOG0789 Protein tyrosine phosphatase 67 1e-11
CE23859 [T] KOG0789 Protein tyrosine phosphatase 67 2e-11
Hs4506311 [T] KOG4228 Protein tyrosine phosphatase 66 4e-11
Hs18860896 [T] KOG4228 Protein tyrosine phosphatase 66 4e-11
CE02705 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and r... 65 5e-11
CE17191 [T] KOG0789 Protein tyrosine phosphatase 65 6e-11
CE07679 [T] KOG0789 Protein tyrosine phosphatase 65 6e-11
Hs4506295 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contai... 65 8e-11
CE23603 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains... 65 8e-11
CE17578 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains... 65 8e-11
CE20481 [T] KOG0789 Protein tyrosine phosphatase 64 1e-10
CE09981 [T] KOG0789 Protein tyrosine phosphatase 64 1e-10
CE06525 [T] KOG0789 Protein tyrosine phosphatase 64 1e-10
Hs19743914 [T] KOG0793 Protein tyrosine phosphatase 63 3e-10
Hs19743912 [T] KOG0793 Protein tyrosine phosphatase 63 3e-10
Hs11386149 [T] KOG0793 Protein tyrosine phosphatase 63 3e-10
CE14225 [T] KOG0789 Protein tyrosine phosphatase 63 3e-10
Hs4506313 [T] KOG0791 Protein tyrosine phosphatase contains fn3 ... 62 4e-10
CE26346 [T] KOG0789 Protein tyrosine phosphatase 62 4e-10
CE10628 [T] KOG0789 Protein tyrosine phosphatase 62 4e-10
Hs4885567 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contai... 62 5e-10
CE16864 [T] KOG0789 Protein tyrosine phosphatase 62 5e-10
At1g71860 [T] KOG0789 Protein tyrosine phosphatase 62 7e-10
CE27280 [T] KOG0789 Protein tyrosine phosphatase 61 9e-10
CE15324 [T] KOG0789 Protein tyrosine phosphatase 61 1e-09
7292074 [T] KOG0789 Protein tyrosine phosphatase 60 2e-09
CE03652 [T] KOG4228 Protein tyrosine phosphatase 59 6e-09
Hs17434186 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 58 8e-09
Hs18375655 [T] KOG0789 Protein tyrosine phosphatase 57 1e-08
Hs4506321 [T] KOG0793 Protein tyrosine phosphatase 57 2e-08
CE20702 [T] KOG0789 Protein tyrosine phosphatase 56 3e-08
YOR208w [T] KOG0789 Protein tyrosine phosphatase 56 4e-08
CE15349 [T] KOG0789 Protein tyrosine phosphatase 55 5e-08
CE25558 [T] KOG0789 Protein tyrosine phosphatase 55 7e-08
CE03852 [T] KOG0789 Protein tyrosine phosphatase 54 1e-07
CE18278 [T] KOG0789 Protein tyrosine phosphatase 54 2e-07
CE10618 [T] KOG0789 Protein tyrosine phosphatase 51 1e-06
CE04159 [T] KOG0789 Protein tyrosine phosphatase 50 3e-06
7296136 [T] KOG0793 Protein tyrosine phosphatase 49 5e-06
CE12028 [T] KOG0789 Protein tyrosine phosphatase 48 8e-06
7297098 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains... 48 8e-06
>YDL230w [T] KOG0789 Protein tyrosine phosphatase
Length = 335
Score = 191 bits (486), Expect = 5e-49
Identities = 100/207 (48%), Positives = 138/207 (66%), Gaps = 11/207 (5%)
Query: 2 PEEDISVVMVTPLVEQGREKCYAYWPRS-LNETMFSPAIQKTGPSPEDVSHFAFGLELEN 60
P ++I +VMVTPLVE REKCY YWPR +++T+ + ++ D++ F L++E
Sbjct: 122 PLDNIVIVMVTPLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFPSDLKIEF 181
Query: 61 VLTQNCQ-HYTVSKILLKPSDPSF-PVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTS 118
V + +YTV+ I L P+DP PVKTV+HFY+D W DM +PEE+ P+ L H H+
Sbjct: 182 VNVHKVKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSL 241
Query: 119 SDPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKD--------DEFIHSYDKDLIEQIV 170
+ NPI VHCSAGVGR+GT++ALDHL+ T+DFK+ D Y +DLIEQIV
Sbjct: 242 NSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITERSRHSDRATEEYTRDLIEQIV 301
Query: 171 RQLRTQRLKTVESPQQYLFIYHAAKQI 197
QLR+QR+K V++ Q+LFIYHAAK +
Sbjct: 302 LQLRSQRMKMVQTKDQFLFIYHAAKYL 328
>SPAC26F1.10c [T] KOG0789 Protein tyrosine phosphatase
Length = 550
Score = 86.3 bits (212), Expect = 3e-17
Identities = 62/189 (32%), Positives = 92/189 (47%), Gaps = 23/189 (12%)
Query: 7 SVVMVTPLVEQGREKCYAYWP-RSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQN 65
++VM+ L E GRE C AYWP + + S E+V + F L + N
Sbjct: 364 TIVMLGSLFEAGREMCTAYWPSNGIGDKQVYGDYCVKQISEENVDNSRFILRKFEIQNAN 423
Query: 66 CQHYTVSKILLKPSDPSFP-VKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNP 124
FP VK V+H+ Y WSD PE + + +K+V+ S N
Sbjct: 424 -----------------FPSVKKVHHYQYPNWSDCNSPENVKSMVEFLKYVNNSHGSGNT 466
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSY--DKDLIEQIVRQLRTQRLKTVE 182
I VHCSAGVGR+GT++ LD I + + K F S D++ Q+V +R QR+K V+
Sbjct: 467 I-VHCSAGVGRTGTFIVLD-TILRFPESKLSGFNPSVADSSDVVFQLVDHIRKQRMKMVQ 524
Query: 183 SPQQYLFIY 191
+ Q+ ++Y
Sbjct: 525 TFTQFKYVY 533
>SPAC19D5.01 [T] KOG0789 Protein tyrosine phosphatase
Length = 711
Score = 86.3 bits (212), Expect = 3e-17
Identities = 56/191 (29%), Positives = 94/191 (48%), Gaps = 32/191 (16%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T L E G EKC YWP + + + GL + + +
Sbjct: 527 IVMLTNLYEAGSEKCSQYWPDNKDHALCLEG----------------GLRISVQKYETFE 570
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
V+ L + P+ P K ++HF+ W D P+ I + +++ + + P+FV
Sbjct: 571 DLKVNTHLFRLDKPNGPPKYIHHFWVHTWFDKTHPD-IESITGIIRCIDKVPND-GPMFV 628
Query: 128 HCSAGVGRSGTYMALD-------HLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
HCSAGVGR+GT++A+D +++ KT + +D KD I V LR+QR+K
Sbjct: 629 HCSAGVGRTGTFIAVDQILQVPKNILPKTTNLED-------SKDFIFNCVNSLRSQRMKM 681
Query: 181 VESPQQYLFIY 191
V++ +Q+ F+Y
Sbjct: 682 VQNFEQFKFLY 692
>SPAC11E3.09 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 303
Score = 84.3 bits (207), Expect = 1e-16
Identities = 61/196 (31%), Positives = 98/196 (49%), Gaps = 25/196 (12%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQ-NC 66
+VM+T L E+ R KC YWP L ET+ + D+S + L +
Sbjct: 120 IVMLTKLRERHRLKCDIYWPVELFETL----------NIGDLSVILVKVYTLTSLNEVQV 169
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIG--PLHHLMKHVHTSSD-PFN 123
+ + ++K +K K + HFYY+ W D P L +K + S D
Sbjct: 170 REFELNKDGVK--------KKILHFYYNGWPDFGAPHTFSLLSLTRYIKSLSYSPDFETA 221
Query: 124 PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVES 183
PI VHCSAG GR+GT+MAL ++++T D ++ D I IV LR+QR+++V+S
Sbjct: 222 PIIVHCSAGCGRTGTFMALFEILSQT---DDSTSTSKFEVDNIANIVSSLRSQRMQSVQS 278
Query: 184 PQQYLFIYHAAKQIFR 199
Q +F+Y ++++ +
Sbjct: 279 VDQLVFLYTVSQELLQ 294
>CE03335 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1367
Score = 83.6 bits (205), Expect = 2e-16
Identities = 57/198 (28%), Positives = 95/198 (47%), Gaps = 32/198 (16%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
+++ +T VE+GR+KC+ YWP E+V +E+ V +
Sbjct: 1166 AIIALTKCVEKGRDKCHQYWP-----------------DHENVPVLYGDIEVTIVAEKEF 1208
Query: 67 QHYTVSKILLKPSDPSFPV-KTVNHFYYDQWSDM---ERPEEIGPLHHLMKHVHTSSDPF 122
+ + I L+ S P V + V H++Y W D P I + +H H P
Sbjct: 1209 DEFVIRDIRLEKSGPDGRVTRFVRHWHYMAWPDFGAPSHPNGIIQFSRMFRH-HLPHSPH 1267
Query: 123 N-PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
N P VHCSAGVGRSGT++++D L+ ++ F D + V ++R +R + V
Sbjct: 1268 NAPTIVHCSAGVGRSGTFISIDRLL-QSSSFGDPIDVFG--------TVCEMRYERCQMV 1318
Query: 182 ESPQQYLFIYHAAKQIFR 199
++ QQY+FI++ Q+ +
Sbjct: 1319 QNEQQYIFIHYCILQVLQ 1336
>7290546 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1767
Score = 82.4 bits (202), Expect = 4e-16
Identities = 56/189 (29%), Positives = 94/189 (49%), Gaps = 37/189 (19%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
++VM+T E+GREKC YWP + V+ F ++++ ++ +
Sbjct: 1423 AIVMLTRCFEKGREKCDQYWP------------------VDRVAMFYGDIKVQLIIDTHY 1464
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSD----PF 122
+++S+ ++ + S + + HF++ W D PE P L++ V D
Sbjct: 1465 HDWSISEFMVSRNCES---RIMRHFHFTTWPDFGVPE---PPQSLVRFVRAFRDVIGTDM 1518
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
PI VHCSAGVGRSGT++ALD ++ + IH D I IV +R +R+ V+
Sbjct: 1519 RPIIVHCSAGVGRSGTFIALDRIL---------QHIHKSDYVDIFGIVFAMRKERVFMVQ 1569
Query: 183 SPQQYLFIY 191
+ QQY+ I+
Sbjct: 1570 TEQQYVCIH 1578
>Hs18104993 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 624
Score = 81.6 bits (200), Expect = 7e-16
Identities = 55/202 (27%), Positives = 87/202 (42%), Gaps = 35/202 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM T VE+GR KC YWP + + P + N +
Sbjct: 347 IVMTTREVEKGRNKCVPYWPEVGMQRAYGP------------------YSVTNCGEHDTT 388
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF---NP 124
Y + + + P D ++ + H+ Y W D P E G + + ++ + P
Sbjct: 389 EYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGP 448
Query: 125 IFVHCSAGVGRSGTYMALDHLI----TKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
I VHCSAG+GR+GT + +D L+ TK +D D I++ ++ +R QR
Sbjct: 449 IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID----------IQKTIQMVRAQRSGM 498
Query: 181 VESPQQYLFIYHAAKQIFRYTR 202
V++ QY FIY A Q T+
Sbjct: 499 VQTEAQYKFIYVAIAQFIETTK 520
>Hs18104991 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 597
Score = 81.6 bits (200), Expect = 7e-16
Identities = 55/202 (27%), Positives = 87/202 (42%), Gaps = 35/202 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM T VE+GR KC YWP + + P + N +
Sbjct: 349 IVMTTREVEKGRNKCVPYWPEVGMQRAYGP------------------YSVTNCGEHDTT 390
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF---NP 124
Y + + + P D ++ + H+ Y W D P E G + + ++ + P
Sbjct: 391 EYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGP 450
Query: 125 IFVHCSAGVGRSGTYMALDHLI----TKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
I VHCSAG+GR+GT + +D L+ TK +D D I++ ++ +R QR
Sbjct: 451 IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID----------IQKTIQMVRAQRSGM 500
Query: 181 VESPQQYLFIYHAAKQIFRYTR 202
V++ QY FIY A Q T+
Sbjct: 501 VQTEAQYKFIYVAIAQFIETTK 522
>Hs18104989 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 595
Score = 81.6 bits (200), Expect = 7e-16
Identities = 55/202 (27%), Positives = 87/202 (42%), Gaps = 35/202 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM T VE+GR KC YWP + + P + N +
Sbjct: 347 IVMTTREVEKGRNKCVPYWPEVGMQRAYGP------------------YSVTNCGEHDTT 388
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF---NP 124
Y + + + P D ++ + H+ Y W D P E G + + ++ + P
Sbjct: 389 EYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGP 448
Query: 125 IFVHCSAGVGRSGTYMALDHLI----TKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
I VHCSAG+GR+GT + +D L+ TK +D D I++ ++ +R QR
Sbjct: 449 IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID----------IQKTIQMVRAQRSGM 498
Query: 181 VESPQQYLFIYHAAKQIFRYTR 202
V++ QY FIY A Q T+
Sbjct: 499 VQTEAQYKFIYVAIAQFIETTK 520
>7301780 [T] KOG0789 Protein tyrosine phosphatase
Length = 1285
Score = 81.6 bits (200), Expect = 7e-16
Identities = 56/187 (29%), Positives = 90/187 (47%), Gaps = 24/187 (12%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T LVE+GR KC YWP+ ET ++ +E E + T +
Sbjct: 562 IVMITNLVERGRRKCDMYWPKDGVETYGVIQVKL--------------IEEEVMSTYTVR 607
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP-FNPIF 126
+ + LK K V ++Y W D P+ P+ + +K ++ PI
Sbjct: 608 TLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIV 667
Query: 127 VHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQ 186
VHCSAGVGR+GTY+ LD ++ K I K+ + + +R +R QR V++ +Q
Sbjct: 668 VHCSAGVGRTGTYIVLDAML-KQIQQKNIVNVFGF--------LRHIRAQRNFLVQTEEQ 718
Query: 187 YLFIYHA 193
Y+F++ A
Sbjct: 719 YIFLHDA 725
>Hs18104986 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM
domain
Length = 913
Score = 81.3 bits (199), Expect = 9e-16
Identities = 51/191 (26%), Positives = 90/191 (46%), Gaps = 28/191 (14%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T L E+GR KC+ YWP P+ ++H F ++ ++ ++C
Sbjct: 740 IVMLTTLTERGRTKCHQYWP----------------DPPDVMNHGGFHIQCQS---EDCT 780
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
VS+ +L + + TV H Y W D P++ + +V + P+ V
Sbjct: 781 IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPLLV 840
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HCSAG+GR+G + ++ + T + + Y D IVR++R QR V++ QY
Sbjct: 841 HCSAGIGRTGVLVTMETAMCLT-----ERNLPIYPLD----IVRKMRDQRAMMVQTSSQY 891
Query: 188 LFIYHAAKQIF 198
F+ A +++
Sbjct: 892 KFVCEAILRVY 902
>7290264 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 945
Score = 80.9 bits (198), Expect = 1e-15
Identities = 53/199 (26%), Positives = 93/199 (46%), Gaps = 41/199 (20%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM T E+G+EKC YWP F A ++ V +
Sbjct: 575 IVMTTKEYERGKEKCARYWPDEGRSEQFGHA------------------RIQCVSENSTS 616
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT-------SSD 120
YT+ + L+ D P + + H+++ W D P + G + + ++ V+T + +
Sbjct: 617 DYTLREFLVSWRDQ--PARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGE 674
Query: 121 PFNPIFVHCSAGVGRSGTY----MALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQ 176
PI VHCSAG+GR+GT+ M LD ++ +D + D I++ ++ +R+Q
Sbjct: 675 KPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEID----------IQRTIQMVRSQ 724
Query: 177 RLKTVESPQQYLFIYHAAK 195
R V++ QY F+Y+A +
Sbjct: 725 RSGLVQTEAQYKFVYYAVQ 743
>7290263 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 845
Score = 80.9 bits (198), Expect = 1e-15
Identities = 53/199 (26%), Positives = 93/199 (46%), Gaps = 41/199 (20%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM T E+G+EKC YWP F A ++ V +
Sbjct: 475 IVMTTKEYERGKEKCARYWPDEGRSEQFGHA------------------RIQCVSENSTS 516
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT-------SSD 120
YT+ + L+ D P + + H+++ W D P + G + + ++ V+T + +
Sbjct: 517 DYTLREFLVSWRDQ--PARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGE 574
Query: 121 PFNPIFVHCSAGVGRSGTY----MALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQ 176
PI VHCSAG+GR+GT+ M LD ++ +D + D I++ ++ +R+Q
Sbjct: 575 KPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEID----------IQRTIQMVRSQ 624
Query: 177 RLKTVESPQQYLFIYHAAK 195
R V++ QY F+Y+A +
Sbjct: 625 RSGLVQTEAQYKFVYYAVQ 643
>Hs4506329 [T] KOG0789 Protein tyrosine phosphatase
Length = 2314
Score = 80.5 bits (197), Expect = 1e-15
Identities = 60/192 (31%), Positives = 87/192 (45%), Gaps = 36/192 (18%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T LVE+GR KC YWP E+ +F + VL
Sbjct: 1822 IVMITNLVEKGRRKCDQYWPAD---------------GSEEYGNFLVTQKSVQVLA---- 1862
Query: 68 HYTVSKILL------KPSDPSFPV-KTVNHFYYDQWSDMERPEEIGP-LHHLMKHVHTSS 119
+YTV L K S P + V ++Y QW DM PE P L + K +
Sbjct: 1863 YYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKR 1922
Query: 120 DPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
P+ VHCSAGVGR+GTY+ LD ++ + I I ++ +R+QR
Sbjct: 1923 HAVGPVVVHCSAGVGRTGTYIVLDSMLQQ---------IQHEGTVNIFGFLKHIRSQRNY 1973
Query: 180 TVESPQQYLFIY 191
V++ +QY+FI+
Sbjct: 1974 LVQTEEQYVFIH 1985
>Hs18860900 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1337
Score = 80.5 bits (197), Expect = 1e-15
Identities = 58/197 (29%), Positives = 87/197 (43%), Gaps = 34/197 (17%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQ-N 65
+++M+T VEQGR KC YWP +D + E VL +
Sbjct: 1134 AIIMLTKCVEQGRTKCEEYWPSK---------------QAQDYGDITVAMTSEIVLPEWT 1178
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPL---HHLMKHVHTSSDPF 122
+ +TV I S P + F++ W D P+ L +L++ S P
Sbjct: 1179 IRDFTVKNIQTSESHP------LRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPE 1232
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
+PI VHCSAGVGR+GT++A+D LI +++ + Y IV LR R V+
Sbjct: 1233 SPILVHCSAGVGRTGTFIAIDRLI---YQIENENTVDVYG------IVYDLRMHRPLMVQ 1283
Query: 183 SPQQYLFIYHAAKQIFR 199
+ QY+F+ I R
Sbjct: 1284 TEDQYVFLNQCVLDIVR 1300
>Hs18491010 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1997
Score = 80.5 bits (197), Expect = 1e-15
Identities = 57/199 (28%), Positives = 93/199 (46%), Gaps = 36/199 (18%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
++VMVT VE+GR KC YWP + + I + + E+VL +
Sbjct: 1797 NIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQ--------------MLSESVLPE-- 1840
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN--- 123
+T+ + + + + + HF+Y W D PE L++ V T D N
Sbjct: 1841 --WTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETT---QSLIQFVRTVRDYINRSP 1895
Query: 124 ---PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
P VHCSAGVGR+GT++ALD ++ + +D KD I+ V LR R+
Sbjct: 1896 GAGPTVVHCSAGVGRTGTFIALDRIL-QQLDSKDSVDIYG--------AVHDLRLHRVHM 1946
Query: 181 VESPQQYLFIYHAAKQIFR 199
V++ QY++++ + + R
Sbjct: 1947 VQTECQYVYLHQCVRDVLR 1965
>Hs18860898_2 [T] KOG0789 Protein tyrosine phosphatase
Length = 745
Score = 80.1 bits (196), Expect = 2e-15
Identities = 53/193 (27%), Positives = 91/193 (46%), Gaps = 31/193 (16%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENV-LTQNC 66
+VM+T LVE+GR KC YWP + E+ + L+ +
Sbjct: 247 IVMITNLVEKGRRKCDQYWPTE---------------NSEEYGNIIVTLKSTKIHACYTV 291
Query: 67 QHYTVSKILLKPSDPSFPV-----KTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP 121
+ +++ +K P + V ++Y QW DM PE P+ ++ + P
Sbjct: 292 RRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMP 351
Query: 122 -FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
P+ VHCSAGVGR+GTY+ +D ++ + KD ++ + ++ +RTQR
Sbjct: 352 ETGPVLVHCSAGVGRTGTYIVIDSMLQQ---IKDKSTVN------VLGFLKHIRTQRNYL 402
Query: 181 VESPQQYLFIYHA 193
V++ +QY+FI+ A
Sbjct: 403 VQTEEQYIFIHDA 415
>CE06093 [T] KOG4228 Protein tyrosine phosphatase
Length = 1156
Score = 79.7 bits (195), Expect = 3e-15
Identities = 54/195 (27%), Positives = 93/195 (47%), Gaps = 30/195 (15%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+V +T +VE G+ KC YWP + Q T S +HF+
Sbjct: 755 IVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFS-------------- 800
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN--PI 125
+ + + + + P+ K V+ ++ W D P + PL + VH +SD + P+
Sbjct: 801 -HRILDLKIAKAVPAVERK-VHQLHFMGWPDHGVPSSVFPL---LSFVHYTSDIHSTGPV 855
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
VHCSAGVGRSG+Y+ +D + I F+ + ++ + +R QR K V++ +
Sbjct: 856 VVHCSAGVGRSGSYILVDSMRRHLISFR---------RLNVQGHLTHMRRQRAKLVQTLE 906
Query: 186 QYLFIYHAAKQIFRY 200
QY+F + A +Q+ R+
Sbjct: 907 QYIFCHEAIRQLIRH 921
>Hs5729993 [T] KOG4228 Protein tyrosine phosphatase
Length = 700
Score = 79.0 bits (193), Expect = 4e-15
Identities = 57/204 (27%), Positives = 93/204 (44%), Gaps = 37/204 (18%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
++ ++VM+T L E+ EKC+ YWP D + +G V
Sbjct: 225 QKSATIVMLTNLKERKEEKCHQYWP--------------------DQGCWTYGNI--RVC 262
Query: 63 TQNCQ---HYTVSKILLKPSDPSF--PVKTVNHFYYDQWSDMERP-EEIGPLHHLMKHVH 116
++C YT+ K ++P P + V+ ++ W D P IG L L K
Sbjct: 263 VEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT 322
Query: 117 TSSDPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQ 176
+ PI VHCSAGVGR+GT++ +D ++ +H+ K + + V ++R Q
Sbjct: 323 LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA---------MMHAEQKVDVFEFVSRIRNQ 373
Query: 177 RLKTVESPQQYLFIYHAAKQIFRY 200
R + V++ QY FIY A + + Y
Sbjct: 374 RPQMVQTDMQYTFIYQALLEYYLY 397
Score = 67.0 bits (162), Expect = 2e-11
Identities = 50/191 (26%), Positives = 88/191 (45%), Gaps = 34/191 (17%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
++VM+T + E+ ++KCY YWP + V+H +E++N
Sbjct: 521 TIVMLTEVQEREQDKCYQYWP-----------------TEGSVTHGEITIEIKNDTLSEA 563
Query: 67 QHYTVSKILLKPSDPSF----PVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF 122
++ L+ + P V+ V F++ W ++ P E + L+ V
Sbjct: 564 --ISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQT 621
Query: 123 --NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
+PI VHCSAG GR+GT++AL +++ + K + + + Q V+ LR QR
Sbjct: 622 GNHPITVHCSAGAGRTGTFIALSNILERV---KAEGLLDVF------QAVKSLRLQRPHM 672
Query: 181 VESPQQYLFIY 191
V++ +QY F Y
Sbjct: 673 VQTLEQYEFCY 683
>Hs18860859 [T] KOG4228 Protein tyrosine phosphatase
Length = 642
Score = 79.0 bits (193), Expect = 4e-15
Identities = 57/204 (27%), Positives = 93/204 (44%), Gaps = 37/204 (18%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
++ ++VM+T L E+ EKC+ YWP D + +G V
Sbjct: 167 QKSATIVMLTNLKERKEEKCHQYWP--------------------DQGCWTYGNI--RVC 204
Query: 63 TQNCQ---HYTVSKILLKPSDPSF--PVKTVNHFYYDQWSDMERP-EEIGPLHHLMKHVH 116
++C YT+ K ++P P + V+ ++ W D P IG L L K
Sbjct: 205 VEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT 264
Query: 117 TSSDPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQ 176
+ PI VHCSAGVGR+GT++ +D ++ +H+ K + + V ++R Q
Sbjct: 265 LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA---------MMHAEQKVDVFEFVSRIRNQ 315
Query: 177 RLKTVESPQQYLFIYHAAKQIFRY 200
R + V++ QY FIY A + + Y
Sbjct: 316 RPQMVQTDMQYTFIYQALLEYYLY 339
Score = 67.0 bits (162), Expect = 2e-11
Identities = 50/191 (26%), Positives = 88/191 (45%), Gaps = 34/191 (17%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
++VM+T + E+ ++KCY YWP + V+H +E++N
Sbjct: 463 TIVMLTEVQEREQDKCYQYWP-----------------TEGSVTHGEITIEIKNDTLSEA 505
Query: 67 QHYTVSKILLKPSDPSF----PVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF 122
++ L+ + P V+ V F++ W ++ P E + L+ V
Sbjct: 506 --ISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQT 563
Query: 123 --NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
+PI VHCSAG GR+GT++AL +++ + K + + + Q V+ LR QR
Sbjct: 564 GNHPITVHCSAGAGRTGTFIALSNILERV---KAEGLLDVF------QAVKSLRLQRPHM 614
Query: 181 VESPQQYLFIY 191
V++ +QY F Y
Sbjct: 615 VQTLEQYEFCY 625
>Hs18375660 [T] KOG0789 Protein tyrosine phosphatase
Length = 399
Score = 79.0 bits (193), Expect = 4e-15
Identities = 52/193 (26%), Positives = 94/193 (47%), Gaps = 35/193 (18%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+E++S++++ + +G+EKC YWP E+ ++ F + ++++
Sbjct: 224 QEEVSLIVMLTQLREGKEKCVHYWPT------------------EEETYGPFQIRIQDM- 264
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF 122
+ C YTV ++ ++ + ++V H + W D + PE GPL L+ V S +
Sbjct: 265 -KECPEYTVRQLTIQYQEER---RSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETA 320
Query: 123 ---NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
PI VHCSAG+GR+G ++A I + + D I IV QLR R
Sbjct: 321 AHPGPIVVHCSAGIGRTGCFIA------TRIGCQQLKARGEVD---ILGIVCQLRLDRGG 371
Query: 180 TVESPQQYLFIYH 192
+++ +QY F++H
Sbjct: 372 MIQTAEQYQFLHH 384
>Hs18375658 [T] KOG0789 Protein tyrosine phosphatase
Length = 360
Score = 79.0 bits (193), Expect = 4e-15
Identities = 52/193 (26%), Positives = 94/193 (47%), Gaps = 35/193 (18%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+E++S++++ + +G+EKC YWP E+ ++ F + ++++
Sbjct: 185 QEEVSLIVMLTQLREGKEKCVHYWPT------------------EEETYGPFQIRIQDM- 225
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF 122
+ C YTV ++ ++ + ++V H + W D + PE GPL L+ V S +
Sbjct: 226 -KECPEYTVRQLTIQYQEER---RSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETA 281
Query: 123 ---NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
PI VHCSAG+GR+G ++A I + + D I IV QLR R
Sbjct: 282 AHPGPIVVHCSAGIGRTGCFIA------TRIGCQQLKARGEVD---ILGIVCQLRLDRGG 332
Query: 180 TVESPQQYLFIYH 192
+++ +QY F++H
Sbjct: 333 MIQTAEQYQFLHH 345
>CE11200 [T] KOG0789 Protein tyrosine phosphatase
Length = 518
Score = 79.0 bits (193), Expect = 4e-15
Identities = 56/191 (29%), Positives = 87/191 (45%), Gaps = 23/191 (12%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
V+M+ L E G EKC Y+P L E + + T E G L ++ N +
Sbjct: 272 VLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEIT--LTECKEEAIAGTILNSLTVINTE 329
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
T S+P + +NH W D PE+ P+ L K V + PI V
Sbjct: 330 DAT--------SEPLY----MNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKEKPICV 377
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HCSAGVGR+ T++ +D+ + ++ + E + IVR++R R + V+S Q+
Sbjct: 378 HCSAGVGRTATFVGIDYATIRIMENPNIEML---------DIVREMRAMRFQAVQSHMQF 428
Query: 188 LFIYHAAKQIF 198
LF+Y + F
Sbjct: 429 LFLYVVLMEYF 439
>CE15903 [T] KOG0789 Protein tyrosine phosphatase
Length = 490
Score = 78.6 bits (192), Expect = 6e-15
Identities = 55/191 (28%), Positives = 84/191 (43%), Gaps = 23/191 (12%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
V+M+ L E G EKC Y+P L E + K + + A + N LT
Sbjct: 271 VLMLCTLFEGGVEKCALYYPEKLGEVV---KFGKYEITLTECKEEAIAGTIWNALT---- 323
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
+ D S +NH W D PE+ P+ L K V + PI V
Sbjct: 324 -------VTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKETPICV 376
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HCSAGVGR+ T++ +D+ + ++ + E + IVR++R R + V+S Q+
Sbjct: 377 HCSAGVGRTATFVGIDYATIRIMENPNIEML---------DIVREMRAMRFQAVQSHMQF 427
Query: 188 LFIYHAAKQIF 198
LF+Y + F
Sbjct: 428 LFLYVVLMEYF 438
>Hs18375642 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 593
Score = 78.2 bits (191), Expect = 7e-15
Identities = 53/195 (27%), Positives = 89/195 (45%), Gaps = 35/195 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM T VE+G+ KC YWP A+++ G + + NV
Sbjct: 353 IVMTTKEVERGKSKCVKYWPDEY-------ALKEYGV-----------MRVRNVKESAAH 394
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF---NP 124
YT+ ++ L +TV +++ W D P + G + ++ VH + P
Sbjct: 395 DYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGP 454
Query: 125 IFVHCSAGVGRSGTYMALDHLI----TKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
+ VHCSAG+GR+GT++ +D LI K +D D + + ++ +R+QR
Sbjct: 455 VVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDID----------VPKTIQMVRSQRSGM 504
Query: 181 VESPQQYLFIYHAAK 195
V++ QY FIY A +
Sbjct: 505 VQTEAQYRFIYMAVQ 519
>Hs4506325 [T] KOG0789 Protein tyrosine phosphatase
Length = 657
Score = 77.4 bits (189), Expect = 1e-14
Identities = 58/195 (29%), Positives = 91/195 (45%), Gaps = 38/195 (19%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFG-LELENV 61
E+ +VM+T L E+ EKC YWP +K G +G +E+ +
Sbjct: 483 EDSPVIVMITKLKEKN-EKCVLYWP------------EKRG---------IYGKVEVLVI 520
Query: 62 LTQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT---S 118
C +YT+ ++LK + VK H++Y W D + P+ PL LM V +
Sbjct: 521 SVNECDNYTIRNLVLKQGSHTQHVK---HYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLA 577
Query: 119 SDPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRL 178
S P+ VHCSAG+GR+G ++A K++ + + IV QLR R
Sbjct: 578 SQGRGPVVVHCSAGIGRTGCFIATS---IGCQQLKEEGVVDAL------SIVCQLRMDRG 628
Query: 179 KTVESPQQYLFIYHA 193
V++ +QY F++HA
Sbjct: 629 GMVQTSEQYEFVHHA 643
>Hs19743917 [T] KOG0789 Protein tyrosine phosphatase
Length = 412
Score = 77.4 bits (189), Expect = 1e-14
Identities = 58/195 (29%), Positives = 91/195 (45%), Gaps = 38/195 (19%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFG-LELENV 61
E+ +VM+T L E+ EKC YWP +K G +G +E+ +
Sbjct: 238 EDSPVIVMITKLKEKN-EKCVLYWP------------EKRG---------IYGKVEVLVI 275
Query: 62 LTQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT---S 118
C +YT+ ++LK + VK H++Y W D + P+ PL LM V +
Sbjct: 276 SVNECDNYTIRNLVLKQGSHTQHVK---HYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLA 332
Query: 119 SDPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRL 178
S P+ VHCSAG+GR+G ++A K++ + + IV QLR R
Sbjct: 333 SQGRGPVVVHCSAGIGRTGCFIATS---IGCQQLKEEGVVDAL------SIVCQLRMDRG 383
Query: 179 KTVESPQQYLFIYHA 193
V++ +QY F++HA
Sbjct: 384 GMVQTSEQYEFVHHA 398
>Hs18860902 [T] KOG4228 Protein tyrosine phosphatase
Length = 1440
Score = 76.6 bits (187), Expect = 2e-14
Identities = 56/192 (29%), Positives = 87/192 (45%), Gaps = 31/192 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
E+ +VMVT LVE GR KCY YWP D + ++ V
Sbjct: 977 EQSACIVMVTNLVEVGRVKCYKYWP--------------------DDTEVYGDFKVTCVE 1016
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF 122
+ Y V L+ + ++ V F++ W D P L ++ V S+ P
Sbjct: 1017 MEPLAEYVVRTFTLERRGYN-EIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS 1075
Query: 123 -NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
PI VHCSAG GR+G Y+ +D + +D + E + I V+ LR++R+ V
Sbjct: 1076 AGPIVVHCSAGAGRTGCYIVIDIM----LDMAEREGVVD-----IYNCVKALRSRRINMV 1126
Query: 182 ESPQQYLFIYHA 193
++ +QY+FI+ A
Sbjct: 1127 QTEEQYIFIHDA 1138
>CE24794 [T] KOG4228 Protein tyrosine phosphatase
Length = 2234
Score = 76.3 bits (186), Expect = 3e-14
Identities = 55/194 (28%), Positives = 89/194 (45%), Gaps = 34/194 (17%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
E+ +++VM+T L E+ R KC YWP T +E+ +
Sbjct: 1770 EQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGD-------------------IEVTLLE 1810
Query: 63 TQNCQHYTVSKILLKP-SDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT-SSD 120
+ + HYT+ + LK +P V+ + H Y W D P+ P +K V T + +
Sbjct: 1811 SVHLAHYTMRTMRLKMVGEPE--VREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPN 1868
Query: 121 PFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL-IEQIVRQLRTQRLK 179
PI HCSAG+GR+G ++ +D ++ + YD + I V LR QR
Sbjct: 1869 DAGPIISHCSAGIGRTGAFIVIDCMLERL----------RYDNTVDIYGCVTALRAQRSY 1918
Query: 180 TVESPQQYLFIYHA 193
V++ +QY+FI+ A
Sbjct: 1919 MVQTEEQYIFIHDA 1932
Score = 66.2 bits (160), Expect = 3e-11
Identities = 50/191 (26%), Positives = 85/191 (44%), Gaps = 34/191 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPE-DVSHFAFGLELENVLTQNC 66
+ M+ E+G+E+C YWP ET + P E D+ H+ +
Sbjct: 2063 IAMLVRTNERGQEQCSDYWPL---ETGVQVGMLVVEPMAEYDMKHY------------HL 2107
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN--- 123
+ + +S I + V+TV F++ +W D+ +P + VH + F
Sbjct: 2108 REFRISDINTRE------VRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGCTG 2161
Query: 124 PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVES 183
PI VHC +G GR+ ++AL ++ + H D + V+ LRT+R ++
Sbjct: 2162 PITVHCCSGAGRTAVFIALSIILDRM------RAEHVVD---VFTTVKLLRTERQNMIQE 2212
Query: 184 PQQYLFIYHAA 194
P+QY F+Y AA
Sbjct: 2213 PEQYHFLYLAA 2223
>Hs4506291 [T] KOG0789 Protein tyrosine phosphatase
Length = 415
Score = 75.1 bits (183), Expect = 6e-14
Identities = 52/190 (27%), Positives = 87/190 (45%), Gaps = 29/190 (15%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
+VVM+ +VE+ KC YWP E +F ++TG F ++L L+++
Sbjct: 108 AVVMLNRIVEKESVKCAQYWPTDDQEMLF----KETG----------FSVKL---LSEDV 150
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSD---PFN 123
+ Y +L + S +T++HF+Y W D PE + + V S
Sbjct: 151 KSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHG 210
Query: 124 PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVES 183
P +HCSAG+GRSGT+ +D + + D I+Q++ +R R+ +++
Sbjct: 211 PAVIHCSAGIGRSGTFSLVDTCLV---------LMEKGDDINIKQVLLNMRKYRMGLIQT 261
Query: 184 PQQYLFIYHA 193
P Q F Y A
Sbjct: 262 PDQLRFSYMA 271
>Hs18104982 [T] KOG0789 Protein tyrosine phosphatase
Length = 353
Score = 75.1 bits (183), Expect = 6e-14
Identities = 52/190 (27%), Positives = 87/190 (45%), Gaps = 29/190 (15%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
+VVM+ +VE+ KC YWP E +F ++TG F ++L L+++
Sbjct: 108 AVVMLNRIVEKESVKCAQYWPTDDQEMLF----KETG----------FSVKL---LSEDV 150
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSD---PFN 123
+ Y +L + S +T++HF+Y W D PE + + V S
Sbjct: 151 KSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHG 210
Query: 124 PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVES 183
P +HCSAG+GRSGT+ +D + + D I+Q++ +R R+ +++
Sbjct: 211 PAVIHCSAGIGRSGTFSLVDTCLV---------LMEKGDDINIKQVLLNMRKYRMGLIQT 261
Query: 184 PQQYLFIYHA 193
P Q F Y A
Sbjct: 262 PDQLRFSYMA 271
>Hs18104980 [T] KOG0789 Protein tyrosine phosphatase
Length = 387
Score = 75.1 bits (183), Expect = 6e-14
Identities = 52/190 (27%), Positives = 87/190 (45%), Gaps = 29/190 (15%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
+VVM+ +VE+ KC YWP E +F ++TG F ++L L+++
Sbjct: 108 AVVMLNRIVEKESVKCAQYWPTDDQEMLF----KETG----------FSVKL---LSEDV 150
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSD---PFN 123
+ Y +L + S +T++HF+Y W D PE + + V S
Sbjct: 151 KSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHG 210
Query: 124 PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVES 183
P +HCSAG+GRSGT+ +D + + D I+Q++ +R R+ +++
Sbjct: 211 PAVIHCSAGIGRSGTFSLVDTCLV---------LMEKGDDINIKQVLLNMRKYRMGLIQT 261
Query: 184 PQQYLFIYHA 193
P Q F Y A
Sbjct: 262 PDQLRFSYMA 271
>CE29408 [T] KOG4228 Protein tyrosine phosphatase
Length = 1442
Score = 75.1 bits (183), Expect = 6e-14
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 41/217 (18%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRS----LNETMFSPA--------------IQKTGP 44
+E +VMV L E+ R++C YWP + + PA I G
Sbjct: 914 QESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGE 973
Query: 45 SPEDVSHFAFGLELENVLTQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPE- 103
DV G+E NV Q S+ +L+ +++ W+D + PE
Sbjct: 974 CGPDVIPNGNGVEYANVPIVKGQFANNSRRILQ-------------YHFTNWNDYKAPEC 1020
Query: 104 EIGPLHHLMKHVHTSSDPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDK 163
G L + + +P+ +HCSAGVGR+GT++++D ++ + + + DK
Sbjct: 1021 STGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCL---------AEDK 1071
Query: 164 DLIEQIVRQLRTQRLKTVESPQQYLFIYHAAKQIFRY 200
I + V LR QR V+S +QY+FIY A + Y
Sbjct: 1072 ANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMY 1108
>CE26369 [T] KOG4228 Protein tyrosine phosphatase
Length = 1407
Score = 75.1 bits (183), Expect = 6e-14
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 41/217 (18%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRS----LNETMFSPA--------------IQKTGP 44
+E +VMV L E+ R++C YWP + + PA I G
Sbjct: 879 QESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFHSDYAIRAFDIAHIGE 938
Query: 45 SPEDVSHFAFGLELENVLTQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPE- 103
DV G+E NV Q S+ +L+ +++ W+D + PE
Sbjct: 939 CGPDVIPNGNGVEYANVPIVKGQFANNSRRILQ-------------YHFTNWNDYKAPEC 985
Query: 104 EIGPLHHLMKHVHTSSDPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDK 163
G L + + +P+ +HCSAGVGR+GT++++D ++ + + + DK
Sbjct: 986 STGLLRFMYRLRELPQFNNSPVVIHCSAGVGRTGTFISIDSMLDQCL---------AEDK 1036
Query: 164 DLIEQIVRQLRTQRLKTVESPQQYLFIYHAAKQIFRY 200
I + V LR QR V+S +QY+FIY A + Y
Sbjct: 1037 ANIFEFVCNLRRQRNLMVQSLEQYVFIYKALAEWHMY 1073
>Hs19743929 [T] KOG4228 Protein tyrosine phosphatase
Length = 1444
Score = 74.7 bits (182), Expect = 8e-14
Identities = 57/192 (29%), Positives = 91/192 (46%), Gaps = 31/192 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
E S+VMVT LVE GR KC YWP ++T I+ T E ++ +
Sbjct: 981 ENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLIETEPLAEYVI-------- 1029
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP- 121
+ +TV K ++ + F++ W D P L ++ V + P
Sbjct: 1030 ----RTFTVQK------KGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE 1079
Query: 122 FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
PI VHCSAG GR+G ++A+D + +D ++E + I VR+LR QR+ V
Sbjct: 1080 AGPIVVHCSAGAGRTGCFIAIDTM----LDMAENEGVVD-----IFNCVRELRAQRVNLV 1130
Query: 182 ESPQQYLFIYHA 193
++ +QY+F++ A
Sbjct: 1131 QTEEQYVFVHDA 1142
>Hs19743927 [T] KOG4228 Protein tyrosine phosphatase
Length = 1463
Score = 74.7 bits (182), Expect = 8e-14
Identities = 57/192 (29%), Positives = 91/192 (46%), Gaps = 31/192 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
E S+VMVT LVE GR KC YWP ++T I+ T E ++ +
Sbjct: 1000 ENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLIETEPLAEYVI-------- 1048
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP- 121
+ +TV K ++ + F++ W D P L ++ V + P
Sbjct: 1049 ----RTFTVQK------KGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPE 1098
Query: 122 FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
PI VHCSAG GR+G ++A+D + +D ++E + I VR+LR QR+ V
Sbjct: 1099 AGPIVVHCSAGAGRTGCFIAIDTM----LDMAENEGVVD-----IFNCVRELRAQRVNLV 1149
Query: 182 ESPQQYLFIYHA 193
++ +QY+F++ A
Sbjct: 1150 QTEEQYVFVHDA 1161
>Hs5453992 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 2466
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 43/192 (22%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNET-MFSPAIQKTGPSPEDVSHFAF-GLELENVLTQN 65
+ M+T VE + KC YWP L +T M S ++ + + F + LE++ T+
Sbjct: 2286 IAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE 2345
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDME---RPEEIGPLHHLMKHVHTSSDPF 122
+H ++H + W D + +P+++ M+H+H S
Sbjct: 2346 VRH-------------------ISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSG--- 2383
Query: 123 NPIFVHCSAGVGRSGTYMALD---HLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
PI HCSAG+GRSGT + +D LI++ +DF I +VR +R QR
Sbjct: 2384 -PIITHCSAGIGRSGTLICIDVVLGLISQDLDFD------------ISDLVRCMRLQRHG 2430
Query: 180 TVESPQQYLFIY 191
V++ QY+F Y
Sbjct: 2431 MVQTEDQYIFCY 2442
>Hs18375650 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 2490
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 43/192 (22%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNET-MFSPAIQKTGPSPEDVSHFAF-GLELENVLTQN 65
+ M+T VE + KC YWP L +T M S ++ + + F + LE++ T+
Sbjct: 2310 IAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE 2369
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDME---RPEEIGPLHHLMKHVHTSSDPF 122
+H ++H + W D + +P+++ M+H+H S
Sbjct: 2370 VRH-------------------ISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSG--- 2407
Query: 123 NPIFVHCSAGVGRSGTYMALD---HLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
PI HCSAG+GRSGT + +D LI++ +DF I +VR +R QR
Sbjct: 2408 -PIITHCSAGIGRSGTLICIDVVLGLISQDLDFD------------ISDLVRCMRLQRHG 2454
Query: 180 TVESPQQYLFIY 191
V++ QY+F Y
Sbjct: 2455 MVQTEDQYIFCY 2466
>Hs18375648 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 2294
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 43/192 (22%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNET-MFSPAIQKTGPSPEDVSHFAF-GLELENVLTQN 65
+ M+T VE + KC YWP L +T M S ++ + + F + LE++ T+
Sbjct: 2114 IAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE 2173
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDME---RPEEIGPLHHLMKHVHTSSDPF 122
+H ++H + W D + +P+++ M+H+H S
Sbjct: 2174 VRH-------------------ISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSG--- 2211
Query: 123 NPIFVHCSAGVGRSGTYMALD---HLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
PI HCSAG+GRSGT + +D LI++ +DF I +VR +R QR
Sbjct: 2212 -PIITHCSAGIGRSGTLICIDVVLGLISQDLDFD------------ISDLVRCMRLQRHG 2258
Query: 180 TVESPQQYLFIY 191
V++ QY+F Y
Sbjct: 2259 MVQTEDQYIFCY 2270
>Hs18375646 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 2485
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 43/192 (22%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNET-MFSPAIQKTGPSPEDVSHFAF-GLELENVLTQN 65
+ M+T VE + KC YWP L +T M S ++ + + F + LE++ T+
Sbjct: 2305 IAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTRE 2364
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDME---RPEEIGPLHHLMKHVHTSSDPF 122
+H ++H + W D + +P+++ M+H+H S
Sbjct: 2365 VRH-------------------ISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSG--- 2402
Query: 123 NPIFVHCSAGVGRSGTYMALD---HLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
PI HCSAG+GRSGT + +D LI++ +DF I +VR +R QR
Sbjct: 2403 -PIITHCSAGIGRSGTLICIDVVLGLISQDLDFD------------ISDLVRCMRLQRHG 2449
Query: 180 TVESPQQYLFIY 191
V++ QY+F Y
Sbjct: 2450 MVQTEDQYIFCY 2461
>Hs18641364 [T] KOG4228 Protein tyrosine phosphatase
Length = 1256
Score = 73.9 bits (180), Expect = 1e-13
Identities = 56/188 (29%), Positives = 83/188 (43%), Gaps = 29/188 (15%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLT-QNC 66
+VMVT E R KC YWP T AFG + + + C
Sbjct: 698 IVMVTRCEEGNRNKCAEYWPSMEEGTR------------------AFGDVVVKINQHKRC 739
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN-PI 125
Y + K+ + + V H + W D PE+ L L + V+ S+ F+ PI
Sbjct: 740 PDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPI 799
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
VHCSAGVGR+GTY+ +D ++ E + + +K + V +LR QR V+
Sbjct: 800 VVHCSAGVGRTGTYIGIDAML---------EGLEAENKVDVYGYVVKLRRQRCLMVQVEA 850
Query: 186 QYLFIYHA 193
QY+ I+ A
Sbjct: 851 QYILIHQA 858
>Hs18641362 [T] KOG4228 Protein tyrosine phosphatase
Length = 1143
Score = 73.9 bits (180), Expect = 1e-13
Identities = 56/188 (29%), Positives = 83/188 (43%), Gaps = 29/188 (15%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLT-QNC 66
+VMVT E R KC YWP T AFG + + + C
Sbjct: 585 IVMVTRCEEGNRNKCAEYWPSMEEGTR------------------AFGDVVVKINQHKRC 626
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN-PI 125
Y + K+ + + V H + W D PE+ L L + V+ S+ F+ PI
Sbjct: 627 PDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPI 686
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
VHCSAGVGR+GTY+ +D ++ E + + +K + V +LR QR V+
Sbjct: 687 VVHCSAGVGRTGTYIGIDAML---------EGLEAENKVDVYGYVVKLRRQRCLMVQVEA 737
Query: 186 QYLFIYHA 193
QY+ I+ A
Sbjct: 738 QYILIHQA 745
>Hs18641347 [T] KOG4228 Protein tyrosine phosphatase
Length = 1304
Score = 73.9 bits (180), Expect = 1e-13
Identities = 56/188 (29%), Positives = 83/188 (43%), Gaps = 29/188 (15%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLT-QNC 66
+VMVT E R KC YWP T AFG + + + C
Sbjct: 746 IVMVTRCEEGNRNKCAEYWPSMEEGTR------------------AFGDVVVKINQHKRC 787
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN-PI 125
Y + K+ + + V H + W D PE+ L L + V+ S+ F+ PI
Sbjct: 788 PDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPI 847
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
VHCSAGVGR+GTY+ +D ++ E + + +K + V +LR QR V+
Sbjct: 848 VVHCSAGVGRTGTYIGIDAML---------EGLEAENKVDVYGYVVKLRRQRCLMVQVEA 898
Query: 186 QYLFIYHA 193
QY+ I+ A
Sbjct: 899 QYILIHQA 906
>Hs4506323 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1188
Score = 73.6 bits (179), Expect = 2e-13
Identities = 56/193 (29%), Positives = 92/193 (47%), Gaps = 37/193 (19%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T E+ R KC YWP + E + I S E+ +A C+
Sbjct: 1005 IVMLTQCNEKRRVKCDHYWPFT-EEPIAYGDITVEMISEEEQDDWA------------CR 1051
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERP-----EEIGPLHHLMKHVHTSSDPF 122
H+ ++ + ++ V HF Y W D P E I H+++ T S
Sbjct: 1052 HFRINY--------ADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSK-- 1101
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
P+ +HCSAGVGR+GT++ALD L+ +D EF+ I +V ++R+ R+ V+
Sbjct: 1102 GPMIIHCSAGVGRTGTFIALDRLLQ---HIRDHEFVD------ILGLVSEMRSYRMSMVQ 1152
Query: 183 SPQQYLFIYHAAK 195
+ +QY+FI+ +
Sbjct: 1153 TEEQYIFIHQCVQ 1165
>Hs18860904 [T] KOG4228 Protein tyrosine phosphatase
Length = 1452
Score = 73.6 bits (179), Expect = 2e-13
Identities = 51/192 (26%), Positives = 88/192 (45%), Gaps = 31/192 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
E S++MVT LVE GR KC YWP D + +++ +
Sbjct: 989 ENTASIIMVTNLVEVGRVKCCKYWP--------------------DDTEIYKDIKVTLIE 1028
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF 122
T+ Y + ++ ++ + F++ W D P L ++ V + S P
Sbjct: 1029 TELLAEYVIRTFAVEKRGVH-EIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1087
Query: 123 -NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
P+ VHCSAG GR+G ++ +D + +D + E + I VR+LR++R+ V
Sbjct: 1088 AGPLVVHCSAGAGRTGCFIVIDIM----LDMAEREGVVD-----IYNCVRELRSRRVNMV 1138
Query: 182 ESPQQYLFIYHA 193
++ +QY+FI+ A
Sbjct: 1139 QTEEQYVFIHDA 1150
>Hs13677218 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 405
Score = 73.6 bits (179), Expect = 2e-13
Identities = 56/193 (29%), Positives = 92/193 (47%), Gaps = 37/193 (19%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T E+ R KC YWP + E + I S E+ +A C+
Sbjct: 222 IVMLTQCNEKRRVKCDHYWPFT-EEPIAYGDITVEMISEEEQDDWA------------CR 268
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERP-----EEIGPLHHLMKHVHTSSDPF 122
H+ ++ + ++ V HF Y W D P E I H+++ T S
Sbjct: 269 HFRINY--------ADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSK-- 318
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
P+ +HCSAGVGR+GT++ALD L+ +D EF+ I +V ++R+ R+ V+
Sbjct: 319 GPMIIHCSAGVGRTGTFIALDRLLQ---HIRDHEFVD------ILGLVSEMRSYRMSMVQ 369
Query: 183 SPQQYLFIYHAAK 195
+ +QY+FI+ +
Sbjct: 370 TEEQYIFIHQCVQ 382
>Hs13677216 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 377
Score = 73.6 bits (179), Expect = 2e-13
Identities = 56/193 (29%), Positives = 92/193 (47%), Gaps = 37/193 (19%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T E+ R KC YWP + E + I S E+ +A C+
Sbjct: 194 IVMLTQCNEKRRVKCDHYWPFT-EEPIAYGDITVEMISEEEQDDWA------------CR 240
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERP-----EEIGPLHHLMKHVHTSSDPF 122
H+ ++ + ++ V HF Y W D P E I H+++ T S
Sbjct: 241 HFRINY--------ADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSK-- 290
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
P+ +HCSAGVGR+GT++ALD L+ +D EF+ I +V ++R+ R+ V+
Sbjct: 291 GPMIIHCSAGVGRTGTFIALDRLLQ---HIRDHEFVD------ILGLVSEMRSYRMSMVQ 341
Query: 183 SPQQYLFIYHAAK 195
+ +QY+FI+ +
Sbjct: 342 TEEQYIFIHQCVQ 354
>Hs13677214 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1216
Score = 73.6 bits (179), Expect = 2e-13
Identities = 56/193 (29%), Positives = 92/193 (47%), Gaps = 37/193 (19%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T E+ R KC YWP + E + I S E+ +A C+
Sbjct: 1033 IVMLTQCNEKRRVKCDHYWPFT-EEPIAYGDITVEMISEEEQDDWA------------CR 1079
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERP-----EEIGPLHHLMKHVHTSSDPF 122
H+ ++ + ++ V HF Y W D P E I H+++ T S
Sbjct: 1080 HFRINY--------ADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSK-- 1129
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
P+ +HCSAGVGR+GT++ALD L+ +D EF+ I +V ++R+ R+ V+
Sbjct: 1130 GPMIIHCSAGVGRTGTFIALDRLLQ---HIRDHEFVD------ILGLVSEMRSYRMSMVQ 1180
Query: 183 SPQQYLFIYHAAK 195
+ +QY+FI+ +
Sbjct: 1181 TEEQYIFIHQCVQ 1193
>CE09014 [T] KOG0789 Protein tyrosine phosphatase
Length = 346
Score = 73.6 bits (179), Expect = 2e-13
Identities = 48/193 (24%), Positives = 94/193 (47%), Gaps = 21/193 (10%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETM-FSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
+ M+ L+E+G KC+ Y+P + M F QK E ++F + +
Sbjct: 148 IFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGGQKISVKCESSVTYSFRSDAK------- 200
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIF 126
+ T ++I+++ P + H++++ W D P + L+++ S PI
Sbjct: 201 ANVTATEIVIE--GPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK---GPIV 255
Query: 127 VHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQ 186
VHCSAG+GR+G+ + L++++ D+ + D E+I+ ++R QR ++++ Q
Sbjct: 256 VHCSAGIGRTGSVVMLEYIM--------DQLLAGQIIDDGEKILVKIREQRNNSIQTDAQ 307
Query: 187 YLFIYHAAKQIFR 199
YLF++ FR
Sbjct: 308 YLFVHQVILNYFR 320
>Hs4506289 [T] KOG0789 Protein tyrosine phosphatase
Length = 435
Score = 72.8 bits (177), Expect = 3e-13
Identities = 55/202 (27%), Positives = 87/202 (42%), Gaps = 31/202 (15%)
Query: 8 VVMVTPLVEQGREKCYAYWP-RSLNETMFSPAIQKTGPSPEDVSHF--AFGLELENVLTQ 64
VVM+ ++E+G KC YWP + E +F K ED+ + LELEN+ TQ
Sbjct: 107 VVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQ 166
Query: 65 NCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTS---SDP 121
+ + HF+Y W D PE + + V S S
Sbjct: 167 E-------------------TREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPE 207
Query: 122 FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
P+ VHCSAG+GRSGT+ D + KD + I++++ ++R R+ +
Sbjct: 208 HGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVD------IKKVLLEMRKFRMGLI 261
Query: 182 ESPQQYLFIYHAAKQIFRYTRG 203
++ Q F Y A + ++ G
Sbjct: 262 QTADQLRFSYLAVIEGAKFIMG 283
>Hs4506303 [T] KOG4228 Protein tyrosine phosphatase
Length = 802
Score = 72.4 bits (176), Expect = 4e-13
Identities = 59/198 (29%), Positives = 90/198 (44%), Gaps = 32/198 (16%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
++VMVT L E+ KC YWP T + + S EDV+ VL
Sbjct: 335 TIVMVTNLKERKECKCAQYWPDQGCWTYGNIRV-----SVEDVT----------VLVD-- 377
Query: 67 QHYTVSKILLKPSDPSF---PVKTVNHFYYDQWSDMERP-EEIGPLHHLMKHVHTSSDPF 122
YTV K ++ P + + F++ W D P IG L L K +
Sbjct: 378 --YTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYA 435
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
I VHCSAGVGR+GT++ +D ++ + +H+ K + V ++R QR + V+
Sbjct: 436 GAIVVHCSAGVGRTGTFVVIDAML---------DMMHTERKVDVYGFVSRIRAQRCQMVQ 486
Query: 183 SPQQYLFIYHAAKQIFRY 200
+ QY+FIY A + + Y
Sbjct: 487 TDMQYVFIYQALLEHYLY 504
Score = 71.6 bits (174), Expect = 7e-13
Identities = 55/194 (28%), Positives = 93/194 (47%), Gaps = 35/194 (18%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
S+VM+T L E+G+EKC YWP S VS+ +EL+ + C
Sbjct: 628 SIVMLTELEERGQEKCAQYWP-----------------SDGLVSYGDITVELKK--EEEC 668
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEE----IGPLHHLMKHVHTSSDPF 122
+ YTV +L+ + + + + F++ W ++ P + I + + K S +
Sbjct: 669 ESYTVRDLLVTNTREN-KSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGN-- 725
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
+PI VHCSAG GR+GT+ AL ++ + K + + + Q V+ LR QR V+
Sbjct: 726 HPITVHCSAGAGRTGTFCALSTVLERV---KAEGILDVF------QTVKSLRLQRPHMVQ 776
Query: 183 SPQQYLFIYHAAKQ 196
+ +QY F Y ++
Sbjct: 777 TLEQYEFCYKVVQE 790
>Hs18450369 [T] KOG4228 Protein tyrosine phosphatase
Length = 793
Score = 72.4 bits (176), Expect = 4e-13
Identities = 59/198 (29%), Positives = 90/198 (44%), Gaps = 32/198 (16%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
++VMVT L E+ KC YWP T + + S EDV+ VL
Sbjct: 326 TIVMVTNLKERKECKCAQYWPDQGCWTYGNIRV-----SVEDVT----------VLVD-- 368
Query: 67 QHYTVSKILLKPSDPSF---PVKTVNHFYYDQWSDMERP-EEIGPLHHLMKHVHTSSDPF 122
YTV K ++ P + + F++ W D P IG L L K +
Sbjct: 369 --YTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYA 426
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
I VHCSAGVGR+GT++ +D ++ + +H+ K + V ++R QR + V+
Sbjct: 427 GAIVVHCSAGVGRTGTFVVIDAML---------DMMHTERKVDVYGFVSRIRAQRCQMVQ 477
Query: 183 SPQQYLFIYHAAKQIFRY 200
+ QY+FIY A + + Y
Sbjct: 478 TDMQYVFIYQALLEHYLY 495
Score = 71.6 bits (174), Expect = 7e-13
Identities = 55/194 (28%), Positives = 93/194 (47%), Gaps = 35/194 (18%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
S+VM+T L E+G+EKC YWP S VS+ +EL+ + C
Sbjct: 619 SIVMLTELEERGQEKCAQYWP-----------------SDGLVSYGDITVELKK--EEEC 659
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEE----IGPLHHLMKHVHTSSDPF 122
+ YTV +L+ + + + + F++ W ++ P + I + + K S +
Sbjct: 660 ESYTVRDLLVTNTREN-KSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGN-- 716
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
+PI VHCSAG GR+GT+ AL ++ + K + + + Q V+ LR QR V+
Sbjct: 717 HPITVHCSAGAGRTGTFCALSTVLERV---KAEGILDVF------QTVKSLRLQRPHMVQ 767
Query: 183 SPQQYLFIYHAAKQ 196
+ +QY F Y ++
Sbjct: 768 TLEQYEFCYKVVQE 781
>Hs15619018 [T] KOG0789 Protein tyrosine phosphatase
Length = 691
Score = 72.0 bits (175), Expect = 5e-13
Identities = 50/193 (25%), Positives = 88/193 (44%), Gaps = 27/193 (13%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM E G++KC YW + G + F+ E E +
Sbjct: 125 IVMACMEYEMGKKKCERYWA-------------EPGEMQLEFGPFSVSCEAE----KRKS 167
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT-SSDPFNPIF 126
Y + + +K + + +T+ F+Y W D + P I P+ L+ V D PI
Sbjct: 168 DYIIRTLKVKFNSET---RTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPIC 224
Query: 127 VHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQ 186
+HCSAG GR+G A+D+ + KD ++ + ++R++RTQR V++ +Q
Sbjct: 225 IHCSAGCGRTGVICAIDYT---WMLLKDGIIPENFS---VFSLIREMRTQRPSLVQTQEQ 278
Query: 187 YLFIYHAAKQIFR 199
Y +Y+A ++F+
Sbjct: 279 YELVYNAVLELFK 291
>7292674 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1647
Score = 71.2 bits (173), Expect = 9e-13
Identities = 54/189 (28%), Positives = 86/189 (44%), Gaps = 37/189 (19%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
++VM+T E+GREKC YWP + + + SH+A + E +L +
Sbjct: 1382 AIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQI----LNDSHYADWVMTEFMLCRGS 1437
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN--- 123
+ + + HF++ W D P P L++ V D
Sbjct: 1438 EQ-----------------RILRHFHFTTWPDFGVPN---PPQTLVRFVRAFRDRIGAEQ 1477
Query: 124 -PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
PI VHCSAGVGRSGT++ LD ++ + I++ D I IV +R +R+ V+
Sbjct: 1478 RPIVVHCSAGVGRSGTFITLDRILQQ---------INTSDYVDIFGIVYAMRKERVWMVQ 1528
Query: 183 SPQQYLFIY 191
+ QQY+ I+
Sbjct: 1529 TEQQYICIH 1537
>Hs7706280 [T] KOG0789 Protein tyrosine phosphatase
Length = 807
Score = 70.5 bits (171), Expect = 2e-12
Identities = 49/185 (26%), Positives = 87/185 (46%), Gaps = 27/185 (14%)
Query: 16 EQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQHYTVSKIL 75
E G++KC YW + + + GP F+ E E + Y + +
Sbjct: 133 EMGKKKCERYWAEPVEMQL------EFGP-------FSVSCEAE----KRKSDYIIRTLK 175
Query: 76 LKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT-SSDPFNPIFVHCSAGVG 134
+K + + +T+ F+Y W D + P I P+ L+ V D PI +HCSAG G
Sbjct: 176 VKFNSET---RTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCG 232
Query: 135 RSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQYLFIYHAA 194
R+G A+D+ + KD ++ + ++R++RTQR V++ +QY +Y+A
Sbjct: 233 RTGVICAIDYT---WMLLKDGIIPENFS---VFSLIREMRTQRPSLVQTQEQYELVYNAV 286
Query: 195 KQIFR 199
++F+
Sbjct: 287 LELFK 291
>Hs5902032 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 1174
Score = 70.5 bits (171), Expect = 2e-12
Identities = 62/214 (28%), Positives = 103/214 (47%), Gaps = 42/214 (19%)
Query: 3 EEDISVV-MVTPLVEQGREKCYAYWPR--SLNETMFSPAIQKTGPSPEDVSHFAF-GLEL 58
E+ I+++ MVT E GREK + YWPR S + T+ + T D +A GL++
Sbjct: 987 EQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKM 1046
Query: 59 ENVLTQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEI-GPLHHL------ 111
+++LT +TV H Y W + PE++ G L +L
Sbjct: 1047 KHLLTGQ-------------------ERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSV 1087
Query: 112 MKHVHTSSDPFNP---IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQ 168
+H +++SDP +P + VHCSAGVGR+G + + +I + +E + I +
Sbjct: 1088 RRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIA---CLEHNEVLD------IPR 1138
Query: 169 IVRQLRTQRLKTVESPQQYLFIYHAAKQIFRYTR 202
++ LR QR+ V++ QY F+Y Q + +R
Sbjct: 1139 VLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSR 1172
>7294551 [T] KOG4228 Protein tyrosine phosphatase
Length = 1428
Score = 70.5 bits (171), Expect = 2e-12
Identities = 56/191 (29%), Positives = 84/191 (43%), Gaps = 31/191 (16%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNET-MFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
+VM+T L E + KC YWP + +T F + K + G +E L +
Sbjct: 954 IVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKT------GDYIERTLNVSK 1007
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN--- 123
V + + + ++Y W D PE H ++K + + ++
Sbjct: 1008 NKANVGE--------EEDRRQITQYHYLTWKDFMAPEH---PHGIIKFIRQINSVYSLQR 1056
Query: 124 -PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
PI VHCSAGVGR+GT +ALD LI + + D I V LR QR V+
Sbjct: 1057 GPILVHCSAGVGRTGTLVALDSLIQQ---------LEEEDSVSIYNTVCDLRHQRNFLVQ 1107
Query: 183 SPQQYLFIYHA 193
S +QY+F+Y A
Sbjct: 1108 SLKQYIFLYRA 1118
>Hs19743935 [T] KOG4228 Protein tyrosine phosphatase
Length = 1446
Score = 70.1 bits (170), Expect = 2e-12
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 31/188 (16%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
S+VM+T LVE GR KC YWP ED + +++ V T+
Sbjct: 983 SIVMITKLVEVGRVKCSRYWP-------------------EDSDTYG-DIKIMLVKTETL 1022
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP-FNPI 125
Y V L+ S + V F++ W + P L ++ V S+ P PI
Sbjct: 1023 AEYVVRTFALERRGYSARHE-VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPI 1081
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
+HCSAG GR+G Y+ LD + +D + E + I V+ L ++R+ +++ +
Sbjct: 1082 VIHCSAGTGRTGCYIVLDVM----LDMAECEGVVD-----IYNCVKTLCSRRVNMIQTEE 1132
Query: 186 QYLFIYHA 193
QY+FI+ A
Sbjct: 1133 QYIFIHDA 1140
>Hs19743933 [T] KOG4228 Protein tyrosine phosphatase
Length = 1436
Score = 70.1 bits (170), Expect = 2e-12
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 31/188 (16%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
S+VM+T LVE GR KC YWP ED + +++ V T+
Sbjct: 973 SIVMITKLVEVGRVKCSRYWP-------------------EDSDTYG-DIKIMLVKTETL 1012
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP-FNPI 125
Y V L+ S + V F++ W + P L ++ V S+ P PI
Sbjct: 1013 AEYVVRTFALERRGYSARHE-VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPI 1071
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
+HCSAG GR+G Y+ LD + +D + E + I V+ L ++R+ +++ +
Sbjct: 1072 VIHCSAGTGRTGCYIVLDVM----LDMAECEGVVD-----IYNCVKTLCSRRVNMIQTEE 1122
Query: 186 QYLFIYHA 193
QY+FI+ A
Sbjct: 1123 QYIFIHDA 1130
>Hs19743931 [T] KOG4228 Protein tyrosine phosphatase
Length = 1440
Score = 70.1 bits (170), Expect = 2e-12
Identities = 54/188 (28%), Positives = 86/188 (45%), Gaps = 31/188 (16%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
S+VM+T LVE GR KC YWP ED + +++ V T+
Sbjct: 979 SIVMITKLVEVGRVKCSRYWP-------------------EDSDTYG-DIKIMLVKTETL 1018
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP-FNPI 125
Y V L+ S + V F++ W + P L ++ V S+ P PI
Sbjct: 1019 AEYVVRTFALERRGYSARHE-VRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPI 1077
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
+HCSAG GR+G Y+ LD + +D + E + I V+ L ++R+ +++ +
Sbjct: 1078 VIHCSAGTGRTGCYIVLDVM----LDMAECEGVVD-----IYNCVKTLCSRRVNMIQTEE 1128
Query: 186 QYLFIYHA 193
QY+FI+ A
Sbjct: 1129 QYIFIHDA 1136
>CE28359 [T] KOG0789 Protein tyrosine phosphatase
Length = 456
Score = 70.1 bits (170), Expect = 2e-12
Identities = 56/205 (27%), Positives = 92/205 (44%), Gaps = 34/205 (16%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSP---EDVSHFAFGLELENVLTQ 64
VV++ LVE + KC YWP + E+ + T +D + L++EN T
Sbjct: 183 VVILCKLVELNKIKCERYWPEQVGESELFGDYEITLEEEKLFDDDEYLMRCLKMENQTTG 242
Query: 65 NCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERP---EEIGPLHHLMKHVHTSSDP 121
C + V+ +Y +W D P +++ + LM+++H P
Sbjct: 243 EC-------------------RKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSP 283
Query: 122 --FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
+PI VHCSAGVGR+GT +A++ + + E +HS D I +V LR QR
Sbjct: 284 QDSSPILVHCSAGVGRTGTIIAINFIREQ----MKAETLHSID---IFGLVMTLRKQRAS 336
Query: 180 TVESPQQYLFIYHAAKQIFRYTRGL 204
V++ Q+ F++ R G+
Sbjct: 337 MVQTQDQFQFVHRCIASYCRRHLGI 361
>CE10626 [T] KOG0789 Protein tyrosine phosphatase
Length = 364
Score = 69.7 bits (169), Expect = 3e-12
Identities = 46/191 (24%), Positives = 89/191 (46%), Gaps = 23/191 (12%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
V+M+ +E G+ KC+ YWP + + G +P +S G + + + C
Sbjct: 163 VIMLCNCIETGKIKCHQYWPLEQGQKLVF------GEAPNTISVANLGAK-KMAPDEQCI 215
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
+ T K+ D +T+ H ++ W D P+ +L+ + NPI V
Sbjct: 216 NVTTLKV-----DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ---NPILV 267
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HCSAG+GR+GT +A I + D+ + + + +++++LR+ R ++++ QY
Sbjct: 268 HCSAGIGRTGTIVA--------IAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQY 319
Query: 188 LFIYHAAKQIF 198
L+++ F
Sbjct: 320 LYLHRVLLSYF 330
>CE10616 [T] KOG0789 Protein tyrosine phosphatase
Length = 363
Score = 69.7 bits (169), Expect = 3e-12
Identities = 46/191 (24%), Positives = 89/191 (46%), Gaps = 23/191 (12%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
V+M+ +E G+ KC+ YWP + + G +P +S G + + + C
Sbjct: 162 VIMLCNCIETGKIKCHQYWPLEQGQKLVF------GEAPNTISVANLGAK-KMAPDEQCI 214
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
+ T K+ D +T+ H ++ W D P+ +L+ + NPI V
Sbjct: 215 NVTTLKV-----DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ---NPILV 266
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HCSAG+GR+GT +A I + D+ + + + +++++LR+ R ++++ QY
Sbjct: 267 HCSAGIGRTGTIVA--------IAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQY 318
Query: 188 LFIYHAAKQIF 198
L+++ F
Sbjct: 319 LYLHRVLLSYF 329
>Hs4506309 [T] KOG4228 Protein tyrosine phosphatase
Length = 1912
Score = 69.3 bits (168), Expect = 3e-12
Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 34/191 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1740 VVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1780
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +TV F + W + P+ + VH + + F P
Sbjct: 1781 QYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1839
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL-IEQIVRQLRTQRLKTVES 183
I VHCSAGVGR+G ++ L ++ + Y+ + I Q V+ LRTQR V++
Sbjct: 1840 ISVHCSAGVGRTGVFITLSIVLERM----------RYEGVVDIFQTVKMLRTQRPAMVQT 1889
Query: 184 PQQYLFIYHAA 194
QY F Y AA
Sbjct: 1890 EDQYQFSYRAA 1900
Score = 68.9 bits (167), Expect = 4e-12
Identities = 56/193 (29%), Positives = 83/193 (42%), Gaps = 32/193 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+ +VVM+T L E+ R KC YWP ET GL +L
Sbjct: 1446 QRSATVVMMTKLEERSRVKCDQYWPSRGTET--------------------HGLVQVTLL 1485
Query: 63 -TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP 121
T Y V L + S + V F + W D PE P ++ V T + P
Sbjct: 1486 DTVELATYCVRTFALYKNGSS-EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1544
Query: 122 -FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
P+ VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R QR
Sbjct: 1545 DAGPMVVHCSAGVGRTGCFIVIDAMLER---IKHEKTVDIYGH------VTLMRAQRNYM 1595
Query: 181 VESPQQYLFIYHA 193
V++ QY+FI+ A
Sbjct: 1596 VQTEDQYIFIHDA 1608
>Hs18860894 [T] KOG4228 Protein tyrosine phosphatase
Length = 1501
Score = 69.3 bits (168), Expect = 3e-12
Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 34/191 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1329 VVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1369
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +TV F + W + P+ + VH + + F P
Sbjct: 1370 QYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1428
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL-IEQIVRQLRTQRLKTVES 183
I VHCSAGVGR+G ++ L ++ + Y+ + I Q V+ LRTQR V++
Sbjct: 1429 ISVHCSAGVGRTGVFITLSIVLERM----------RYEGVVDIFQTVKMLRTQRPAMVQT 1478
Query: 184 PQQYLFIYHAA 194
QY F Y AA
Sbjct: 1479 EDQYQFSYRAA 1489
Score = 68.9 bits (167), Expect = 4e-12
Identities = 56/193 (29%), Positives = 83/193 (42%), Gaps = 32/193 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+ +VVM+T L E+ R KC YWP ET GL +L
Sbjct: 1035 QRSATVVMMTKLEERSRVKCDQYWPSRGTET--------------------HGLVQVTLL 1074
Query: 63 -TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP 121
T Y V L + S + V F + W D PE P ++ V T + P
Sbjct: 1075 DTVELATYCVRTFALYKNGSS-EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1133
Query: 122 -FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
P+ VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R QR
Sbjct: 1134 DAGPMVVHCSAGVGRTGCFIVIDAMLER---IKHEKTVDIYGH------VTLMRAQRNYM 1184
Query: 181 VESPQQYLFIYHA 193
V++ QY+FI+ A
Sbjct: 1185 VQTEDQYIFIHDA 1197
>Hs18860892 [T] KOG4228 Protein tyrosine phosphatase
Length = 1903
Score = 69.3 bits (168), Expect = 3e-12
Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 34/191 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1731 VVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1771
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +TV F + W + P+ + VH + + F P
Sbjct: 1772 QYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1830
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL-IEQIVRQLRTQRLKTVES 183
I VHCSAGVGR+G ++ L ++ + Y+ + I Q V+ LRTQR V++
Sbjct: 1831 ISVHCSAGVGRTGVFITLSIVLERM----------RYEGVVDIFQTVKMLRTQRPAMVQT 1880
Query: 184 PQQYLFIYHAA 194
QY F Y AA
Sbjct: 1881 EDQYQFSYRAA 1891
Score = 68.9 bits (167), Expect = 4e-12
Identities = 56/193 (29%), Positives = 83/193 (42%), Gaps = 32/193 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+ +VVM+T L E+ R KC YWP ET GL +L
Sbjct: 1437 QRSATVVMMTKLEERSRVKCDQYWPSRGTET--------------------HGLVQVTLL 1476
Query: 63 -TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP 121
T Y V L + S + V F + W D PE P ++ V T + P
Sbjct: 1477 DTVELATYCVRTFALYKNGSS-EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1535
Query: 122 -FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
P+ VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R QR
Sbjct: 1536 DAGPMVVHCSAGVGRTGCFIVIDAMLER---IKHEKTVDIYGH------VTLMRAQRNYM 1586
Query: 181 VESPQQYLFIYHA 193
V++ QY+FI+ A
Sbjct: 1587 VQTEDQYIFIHDA 1599
>Hs18860890 [T] KOG4228 Protein tyrosine phosphatase
Length = 1899
Score = 69.3 bits (168), Expect = 3e-12
Identities = 54/191 (28%), Positives = 85/191 (44%), Gaps = 34/191 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1727 VVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1767
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +TV F + W + P+ + VH + + F P
Sbjct: 1768 QYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1826
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL-IEQIVRQLRTQRLKTVES 183
I VHCSAGVGR+G ++ L ++ + Y+ + I Q V+ LRTQR V++
Sbjct: 1827 ISVHCSAGVGRTGVFITLSIVLERM----------RYEGVVDIFQTVKMLRTQRPAMVQT 1876
Query: 184 PQQYLFIYHAA 194
QY F Y AA
Sbjct: 1877 EDQYQFSYRAA 1887
Score = 68.9 bits (167), Expect = 4e-12
Identities = 56/193 (29%), Positives = 83/193 (42%), Gaps = 32/193 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+ +VVM+T L E+ R KC YWP ET GL +L
Sbjct: 1433 QRSATVVMMTKLEERSRVKCDQYWPSRGTET--------------------HGLVQVTLL 1472
Query: 63 -TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP 121
T Y V L + S + V F + W D PE P ++ V T + P
Sbjct: 1473 DTVELATYCVRTFALYKNGSS-EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPP 1531
Query: 122 -FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
P+ VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R QR
Sbjct: 1532 DAGPMVVHCSAGVGRTGCFIVIDAMLER---IKHEKTVDIYGH------VTLMRAQRNYM 1582
Query: 181 VESPQQYLFIYHA 193
V++ QY+FI+ A
Sbjct: 1583 VQTEDQYIFIHDA 1595
>Hs22052020_2 [T] KOG0789 Protein tyrosine phosphatase
Length = 307
Score = 69.3 bits (168), Expect = 3e-12
Identities = 54/197 (27%), Positives = 87/197 (43%), Gaps = 38/197 (19%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+ M+T +E G KCY YWP SL + P ++ HF LE +L Q
Sbjct: 138 IAMITREIEGGIIKCYHYWPISLKK-------------PLELKHFRVFLENYQIL----Q 180
Query: 68 HYTVS--KILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPI 125
++ + +++ K + S VK + + +W D P +++ S P+
Sbjct: 181 YFIIRMFQVVEKSTGTSHSVKQLQ---FTKWPDHGTPASADSFIKYIRYAR-KSHLTGPM 236
Query: 126 FVHCSAGVGRSGTYMALDHL---ITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
VHCSAG+GR+G ++ +D + I K F I IV Q+R QR V+
Sbjct: 237 VVHCSAGIGRTGVFLCVDVVFCAIVKNCSFN------------IMDIVAQMREQRSGMVQ 284
Query: 183 SPQQYLFIYHAAKQIFR 199
+ +QY F Y ++ R
Sbjct: 285 TKEQYHFCYDIVLEVLR 301
>Hs19743925 [T] KOG4228 Protein tyrosine phosphatase
Length = 1505
Score = 68.6 bits (166), Expect = 6e-12
Identities = 53/191 (27%), Positives = 85/191 (43%), Gaps = 34/191 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1333 VVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1373
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +TV F + W + P+ + VH + + F P
Sbjct: 1374 QYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1432
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL-IEQIVRQLRTQRLKTVES 183
I VHCSAGVGR+G ++ L ++ + Y+ + I Q V+ LRTQR V++
Sbjct: 1433 ISVHCSAGVGRTGVFITLSIVLERM----------RYEGVVDIFQTVKMLRTQRPAMVQT 1482
Query: 184 PQQYLFIYHAA 194
+Y F Y AA
Sbjct: 1483 EDEYQFCYQAA 1493
Score = 66.2 bits (160), Expect = 3e-11
Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 30/192 (15%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+ ++VM+T L E+ R KC YWP ET IQ T +++ F
Sbjct: 1039 QRSATIVMMTRLEEKSRIKCDQYWPNRGTETY--GFIQVTLLDTIELATFCV-------- 1088
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP- 121
+ +++ K + S + V F + W D PE P ++ V T + P
Sbjct: 1089 ----RTFSLHK------NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1138
Query: 122 FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
PI VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R+QR V
Sbjct: 1139 AGPIVVHCSAGVGRTGCFIVIDAMLER---IKPEKTVDVYGH------VTLMRSQRNYMV 1189
Query: 182 ESPQQYLFIYHA 193
++ QY FI+ A
Sbjct: 1190 QTEDQYSFIHEA 1201
>Hs19743923 [T] KOG4228 Protein tyrosine phosphatase
Length = 1910
Score = 68.6 bits (166), Expect = 6e-12
Identities = 53/191 (27%), Positives = 85/191 (43%), Gaps = 34/191 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1738 VVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1778
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +TV F + W + P+ + VH + + F P
Sbjct: 1779 QYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1837
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL-IEQIVRQLRTQRLKTVES 183
I VHCSAGVGR+G ++ L ++ + Y+ + I Q V+ LRTQR V++
Sbjct: 1838 ISVHCSAGVGRTGVFITLSIVLERM----------RYEGVVDIFQTVKMLRTQRPAMVQT 1887
Query: 184 PQQYLFIYHAA 194
+Y F Y AA
Sbjct: 1888 EDEYQFCYQAA 1898
Score = 66.2 bits (160), Expect = 3e-11
Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 30/192 (15%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+ ++VM+T L E+ R KC YWP ET IQ T +++ F
Sbjct: 1444 QRSATIVMMTRLEEKSRIKCDQYWPNRGTETY--GFIQVTLLDTIELATFCV-------- 1493
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP- 121
+ +++ K + S + V F + W D PE P ++ V T + P
Sbjct: 1494 ----RTFSLHK------NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543
Query: 122 FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
PI VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R+QR V
Sbjct: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLER---IKPEKTVDVYGH------VTLMRSQRNYMV 1594
Query: 182 ESPQQYLFIYHA 193
++ QY FI+ A
Sbjct: 1595 QTEDQYSFIHEA 1606
>Hs19743921 [T] KOG4228 Protein tyrosine phosphatase
Length = 1501
Score = 68.6 bits (166), Expect = 6e-12
Identities = 53/191 (27%), Positives = 85/191 (43%), Gaps = 34/191 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1329 VVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1369
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +TV F + W + P+ + VH + + F P
Sbjct: 1370 QYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1428
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL-IEQIVRQLRTQRLKTVES 183
I VHCSAGVGR+G ++ L ++ + Y+ + I Q V+ LRTQR V++
Sbjct: 1429 ISVHCSAGVGRTGVFITLSIVLERM----------RYEGVVDIFQTVKMLRTQRPAMVQT 1478
Query: 184 PQQYLFIYHAA 194
+Y F Y AA
Sbjct: 1479 EDEYQFCYQAA 1489
Score = 66.2 bits (160), Expect = 3e-11
Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 30/192 (15%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+ ++VM+T L E+ R KC YWP ET IQ T +++ F
Sbjct: 1035 QRSATIVMMTRLEEKSRIKCDQYWPNRGTETY--GFIQVTLLDTIELATFCV-------- 1084
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP- 121
+ +++ K + S + V F + W D PE P ++ V T + P
Sbjct: 1085 ----RTFSLHK------NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1134
Query: 122 FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
PI VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R+QR V
Sbjct: 1135 AGPIVVHCSAGVGRTGCFIVIDAMLER---IKPEKTVDVYGH------VTLMRSQRNYMV 1185
Query: 182 ESPQQYLFIYHA 193
++ QY FI+ A
Sbjct: 1186 QTEDQYSFIHEA 1197
>Hs19743919 [T] KOG4228 Protein tyrosine phosphatase
Length = 1948
Score = 68.6 bits (166), Expect = 6e-12
Identities = 53/191 (27%), Positives = 85/191 (43%), Gaps = 34/191 (17%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1776 VVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1816
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +TV F + W + P+ + VH + + F P
Sbjct: 1817 QYILREFKVTDARDG-QSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGP 1875
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL-IEQIVRQLRTQRLKTVES 183
I VHCSAGVGR+G ++ L ++ + Y+ + I Q V+ LRTQR V++
Sbjct: 1876 ISVHCSAGVGRTGVFITLSIVLERM----------RYEGVVDIFQTVKMLRTQRPAMVQT 1925
Query: 184 PQQYLFIYHAA 194
+Y F Y AA
Sbjct: 1926 EDEYQFCYQAA 1936
Score = 66.2 bits (160), Expect = 3e-11
Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 30/192 (15%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
+ ++VM+T L E+ R KC YWP ET IQ T +++ F
Sbjct: 1482 QRSATIVMMTRLEEKSRIKCDQYWPNRGTETY--GFIQVTLLDTIELATFCV-------- 1531
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDP- 121
+ +++ K + S + V F + W D PE P ++ V T + P
Sbjct: 1532 ----RTFSLHK------NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1581
Query: 122 FNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTV 181
PI VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R+QR V
Sbjct: 1582 AGPIVVHCSAGVGRTGCFIVIDAMLER---IKPEKTVDVYGH------VTLMRSQRNYMV 1632
Query: 182 ESPQQYLFIYHA 193
++ QY FI+ A
Sbjct: 1633 QTEDQYSFIHEA 1644
>CE20664 [T] KOG0789 Protein tyrosine phosphatase
Length = 352
Score = 67.8 bits (164), Expect = 1e-11
Identities = 47/199 (23%), Positives = 95/199 (47%), Gaps = 27/199 (13%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETM-FSPAIQKTGPSPE------DVSHFAFGLELEN 60
+ M+ +E+G +KC+ Y+P + M F QK E + H++F + +
Sbjct: 148 IFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQKISVKCESSVTFIESFHYSFRADAK- 206
Query: 61 VLTQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSD 120
+ T ++I+++ P + H++++ W D P + L+++ S
Sbjct: 207 ------ANVTATEIVIE--GPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK- 257
Query: 121 PFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
PI VHCSAG+GR+G+ + L++++ D+ + D E+I+ ++ QR +
Sbjct: 258 --GPIVVHCSAGIGRTGSVVMLEYIM--------DQLLAGQIIDDGEKILVKICEQRNNS 307
Query: 181 VESPQQYLFIYHAAKQIFR 199
+++ QYLF++ FR
Sbjct: 308 IQTDAQYLFVHQVILNYFR 326
>Hs18375652 [T] KOG0789 Protein tyrosine phosphatase
Length = 780
Score = 67.4 bits (163), Expect = 1e-11
Identities = 53/196 (27%), Positives = 86/196 (43%), Gaps = 31/196 (15%)
Query: 6 ISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQN 65
+ +VM E GR+KC YWP G P + F E E T
Sbjct: 127 VIIVMACREFEMGRKKCERYWPLY-------------GEDPITFAPFKISCEDEQARTD- 172
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERP---EEIGPLHHLMKHVHTSSDPF 122
Y + +LL+ + S + + F+Y W D + P + I + LM+ D
Sbjct: 173 ---YFIRTLLLEFQNES---RRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDV- 225
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
PI +HCSAG GR+G A+D+ K E + ++ +++++RTQR V+
Sbjct: 226 -PICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFN------LIQEMRTQRHSAVQ 278
Query: 183 SPQQYLFIYHAAKQIF 198
+ +QY ++ A Q+F
Sbjct: 279 TKEQYELVHRAIAQLF 294
>CE23859 [T] KOG0789 Protein tyrosine phosphatase
Length = 284
Score = 67.0 bits (162), Expect = 2e-11
Identities = 54/200 (27%), Positives = 91/200 (45%), Gaps = 23/200 (11%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLN-ETM-FSPAIQKTGPSPEDVSHFAFGLELENVLTQ 64
++ M+ E+G +KC+ Y P N +TM F QK E F +
Sbjct: 85 TIFMLCNYKEKGAKKCHEYLPTEDNKDTMSFKEKGQKVTVKFESSKAIKF---------R 135
Query: 65 NCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNP 124
+ V+K +L VNH+++ W D P + L++ S P
Sbjct: 136 DNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSK---GP 192
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESP 184
I VHCSAG+GR+G+ + L++++ + + + I DK I++++R QR +V++
Sbjct: 193 IAVHCSAGIGRTGSVVMLEYVMDQLL---AGQIIEDTDK-----IIQKIREQRNNSVQTD 244
Query: 185 QQYLFIYHAAKQIFRYTRGL 204
QYLF++ F RGL
Sbjct: 245 HQYLFVHQVMMNFFE-KRGL 263
>Hs4506311 [T] KOG4228 Protein tyrosine phosphatase
Length = 1897
Score = 65.9 bits (159), Expect = 4e-11
Identities = 49/190 (25%), Positives = 84/190 (43%), Gaps = 32/190 (16%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1725 IVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1765
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +T+ F + W + P+ + VH + + F P
Sbjct: 1766 QYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGP 1824
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESP 184
I VHCSAGVGR+G ++ L ++ + + + + + Q V+ LRTQR V++
Sbjct: 1825 ITVHCSAGVGRTGVFITLSIVLER---MRYEGVVDMF------QTVKTLRTQRPAMVQTE 1875
Query: 185 QQYLFIYHAA 194
QY Y AA
Sbjct: 1876 DQYQLCYRAA 1885
Score = 64.7 bits (156), Expect = 8e-11
Identities = 55/189 (29%), Positives = 83/189 (43%), Gaps = 32/189 (16%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL-TQN 65
+VVM+T L E+ R KC YWP ET GL +L T
Sbjct: 1435 TVVMMTRLEEKSRVKCDQYWPARGTETC--------------------GLIQVTLLDTVE 1474
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSD-PFNP 124
YTV L S S + + F + W D PE P+ ++ V + P
Sbjct: 1475 LATYTVRTFALHKSGSS-EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGP 1533
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESP 184
+ VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R+QR V++
Sbjct: 1534 MVVHCSAGVGRTGCFIVIDAMLER---MKHEKTVDIYGH------VTCMRSQRNYMVQTE 1584
Query: 185 QQYLFIYHA 193
QY+FI+ A
Sbjct: 1585 DQYVFIHEA 1593
>Hs18860896 [T] KOG4228 Protein tyrosine phosphatase
Length = 1888
Score = 65.9 bits (159), Expect = 4e-11
Identities = 49/190 (25%), Positives = 84/190 (43%), Gaps = 32/190 (16%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+T L E GREKC+ YWP E + + + + ++ + N
Sbjct: 1716 IVMLTKLREMGREKCHQYWPA------------------ERSARYQYFV-VDPMAEYNMP 1756
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN---P 124
Y + + + + +T+ F + W + P+ + VH + + F P
Sbjct: 1757 QYILREFKVTDARDG-QSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGP 1815
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESP 184
I VHCSAGVGR+G ++ L ++ + + + + + Q V+ LRTQR V++
Sbjct: 1816 ITVHCSAGVGRTGVFITLSIVLER---MRYEGVVDMF------QTVKTLRTQRPAMVQTE 1866
Query: 185 QQYLFIYHAA 194
QY Y AA
Sbjct: 1867 DQYQLCYRAA 1876
Score = 64.7 bits (156), Expect = 8e-11
Identities = 55/189 (29%), Positives = 83/189 (43%), Gaps = 32/189 (16%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL-TQN 65
+VVM+T L E+ R KC YWP ET GL +L T
Sbjct: 1426 TVVMMTRLEEKSRVKCDQYWPARGTETC--------------------GLIQVTLLDTVE 1465
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSD-PFNP 124
YTV L S S + + F + W D PE P+ ++ V + P
Sbjct: 1466 LATYTVRTFALHKSGSS-EKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGP 1524
Query: 125 IFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESP 184
+ VHCSAGVGR+G ++ +D ++ + K ++ + Y V +R+QR V++
Sbjct: 1525 MVVHCSAGVGRTGCFIVIDAMLER---MKHEKTVDIYGH------VTCMRSQRNYMVQTE 1575
Query: 185 QQYLFIYHA 193
QY+FI+ A
Sbjct: 1576 DQYVFIHEA 1584
>CE02705 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 668
Score = 65.5 bits (158), Expect = 5e-11
Identities = 55/219 (25%), Positives = 92/219 (41%), Gaps = 37/219 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQ-----------------KTGPS 45
+E+ V+++ + + +EKC YWP +N+ I K
Sbjct: 367 QENSRVIVMPTMENERKEKCARYWPAEVNKPEVHGDISLTCTIERKVQRAVSDEVKAELE 426
Query: 46 PEDVSHFAFGLELENVLTQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEI 105
E + A GL E L + Y + +++K + + + Y W D P
Sbjct: 427 QEKTNRIAKGLVPEAELNGDGISYILRTLVMKKGKDT---REIRQLQYLTWPDHGCPLHP 483
Query: 106 GPLHHLMKHVHTSSDPFN-----------PIFVHCSAGVGRSGTYMALDHLITKTIDFKD 154
+ + ++ V D FN PI VHCSAG+GR+GT + LD L+ + K
Sbjct: 484 YAVLNFLEDVDREYDYFNAQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQV---KK 540
Query: 155 DEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQYLFIYHA 193
+ D + ++V+ +RT R V++ QQY F+Y A
Sbjct: 541 VGLLCPMD---VYKMVKYVRTYRSGLVQTEQQYQFLYKA 576
>CE17191 [T] KOG0789 Protein tyrosine phosphatase
Length = 550
Score = 65.1 bits (157), Expect = 6e-11
Identities = 56/194 (28%), Positives = 95/194 (48%), Gaps = 40/194 (20%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
E ++VM+ +E REKC Y+PR+ +H + +V
Sbjct: 357 ENTTAIVMLCQFLETNREKCAEYFPRN--------------------AHCCLQFDKFSV- 395
Query: 63 TQNCQHYTVSKILLKPS-DPSFPVKT--VNHFYYDQWSDMERPEEIGPLHHLMKHVHTSS 119
N + TV+K L+ + S+ +T + H+ + +W D + PE + +++ + S
Sbjct: 396 --NYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARS 453
Query: 120 DPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHS-YDKDLIEQIVRQLR-TQR 177
P P+ +HCSAGVGRSGT MA++ + + IH+ + I+QIV LR T R
Sbjct: 454 TP--PV-IHCSAGVGRSGTLMAVEIAL---------QSIHTHFTLPDIKQIVSHLRVTGR 501
Query: 178 LKTVESPQQYLFIY 191
+V++ QQY+ I+
Sbjct: 502 AASVQTLQQYMLIW 515
>CE07679 [T] KOG0789 Protein tyrosine phosphatase
Length = 650
Score = 65.1 bits (157), Expect = 6e-11
Identities = 52/185 (28%), Positives = 88/185 (47%), Gaps = 31/185 (16%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+ ++E G+EK Y+P L + M D +++ V++ +
Sbjct: 447 IVMLCEIIELGKEKSANYFPSKLGQAMRIGKFCNITKVQHD--------DIDKVISMS-- 496
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEE-IGPLHHLMKHVHTSSDPFNPIF 126
+ +I + +P F V H ++ W D PE + PLH L ++ S PI
Sbjct: 497 ---LLRITREGQEPVF----VKHVHWHNWPDHGVPESYMSPLHLL--NIFRSHQ--KPIL 545
Query: 127 VHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQ 186
+HCSAGVGR+GT +AL + +T + S D I + +LR +R K +++ Q
Sbjct: 546 IHCSAGVGRTGT-LALILIALQT--------LRSVDFSGIRPLFTRLREERFKAIQTEMQ 596
Query: 187 YLFIY 191
YLF++
Sbjct: 597 YLFVH 601
>Hs4506295 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM
domain
Length = 926
Score = 64.7 bits (156), Expect = 8e-11
Identities = 51/192 (26%), Positives = 83/192 (42%), Gaps = 29/192 (15%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+T VE+GR KC+ YWP + + Q T S E + + F +T Q
Sbjct: 749 VVMLTTQVERGRVKCHQYWPEPTGSSSYG-CYQVTCHSEEGNTAYIF-----RKMTLFNQ 802
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTS-SDPFNPIF 126
S+ L Y W D P++ + HV + P+
Sbjct: 803 EKNESRPL-------------TQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVV 849
Query: 127 VHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQ 186
VHCSAG+GR+G + ++ T + ++ ++ D IVR +R QR +++P Q
Sbjct: 850 VHCSAGIGRTGVLITME---TAMCLIECNQPVYPLD------IVRTMRDQRAMMIQTPSQ 900
Query: 187 YLFIYHAAKQIF 198
Y F+ A +++
Sbjct: 901 YRFVCEAILKVY 912
>CE23603 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM
domain
Length = 624
Score = 64.7 bits (156), Expect = 8e-11
Identities = 48/185 (25%), Positives = 83/185 (43%), Gaps = 29/185 (15%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
++VM+T + E+GR KC+ YWPR + + K +++ T NC
Sbjct: 446 TIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKC---------------IKDKQTTNC 490
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTS-SDPFNPI 125
+ S ++ + S + V Y W D P++ + V + +PI
Sbjct: 491 CYREFS---IRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPI 546
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
VHCSAG+GR+G + ++ T + +E ++ D IVR +R QR +++P
Sbjct: 547 VVHCSAGIGRTGVLILME---TAACLVESNEPVYPLD------IVRTMRDQRAMLIQTPG 597
Query: 186 QYLFI 190
QY F+
Sbjct: 598 QYTFV 602
>CE17578 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 1026
Score = 64.7 bits (156), Expect = 8e-11
Identities = 48/185 (25%), Positives = 83/185 (43%), Gaps = 29/185 (15%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
++VM+T + E+GR KC+ YWPR + + K +++ T NC
Sbjct: 848 TIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKC---------------IKDKQTTNC 892
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTS-SDPFNPI 125
+ S ++ + S + V Y W D P++ + V + +PI
Sbjct: 893 CYREFS---IRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPI 948
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
VHCSAG+GR+G + ++ T + +E ++ D IVR +R QR +++P
Sbjct: 949 VVHCSAGIGRTGVLILME---TAACLVESNEPVYPLD------IVRTMRDQRAMLIQTPG 999
Query: 186 QYLFI 190
QY F+
Sbjct: 1000 QYTFV 1004
>CE20481 [T] KOG0789 Protein tyrosine phosphatase
Length = 398
Score = 64.3 bits (155), Expect = 1e-10
Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 25/191 (13%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+ VE G+ KC YWP + E + K+G E+VS + +E + +
Sbjct: 200 IVMLCKTVEMGKLKCAQYWPAAQGEKL----TLKSGCVVENVSG-SKPMERDPEIQITML 254
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
+ T S +V H + +W D P L+ + S P I V
Sbjct: 255 NLTYS---------GGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKVP---IVV 302
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HCSAG+GR+GT +A+++++ K + K + ++V+ LR QR ++++ QY
Sbjct: 303 HCSAGIGRTGTIVAIEYILEKIAENK--------PCPPMPELVKALRDQRAFSIQNDVQY 354
Query: 188 LFIYHAAKQIF 198
LFI+ F
Sbjct: 355 LFIHRVMLNYF 365
>CE09981 [T] KOG0789 Protein tyrosine phosphatase
Length = 398
Score = 64.3 bits (155), Expect = 1e-10
Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 25/191 (13%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+ VE G+ KC YWP + E + K+G E+VS + +E + +
Sbjct: 200 IVMLCKTVEMGKLKCAQYWPAAQGEKL----TLKSGCVVENVSG-SKPMERDPEIQITML 254
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
+ T S +V H + +W D P L+ + S P I V
Sbjct: 255 NLTYS---------GGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKVP---IVV 302
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HCSAG+GR+GT +A+++++ K + K + ++V+ LR QR ++++ QY
Sbjct: 303 HCSAGIGRTGTIVAIEYILEKIAENK--------PCPPMPELVKALRDQRAFSIQNDVQY 354
Query: 188 LFIYHAAKQIF 198
LFI+ F
Sbjct: 355 LFIHRVMLNYF 365
>CE06525 [T] KOG0789 Protein tyrosine phosphatase
Length = 490
Score = 63.9 bits (154), Expect = 1e-10
Identities = 50/193 (25%), Positives = 89/193 (45%), Gaps = 32/193 (16%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+ +E+ +EKC Y+ D S +G V+ + +
Sbjct: 152 IVMLCQYIEEDQEKCQRYF--------------------SDTSEKEYGDYRVKVVEKTVE 191
Query: 68 HYTVSKIL-LKPSDPSFPVK-TVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPI 125
+ K+ ++ + P K V H++Y W D P + P+ + K V S PI
Sbjct: 192 LWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKSSS-KPI 250
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
VHCSAGVGR+ T++ + I +++ + D++E I+++LRT RL V+S
Sbjct: 251 VVHCSAGVGRTSTFVG---IYLSQIMIRENSSV-----DMVE-ILKRLRTMRLGAVQSQL 301
Query: 186 QYLFIYHAAKQIF 198
QY+++ ++F
Sbjct: 302 QYVYLVVLMIELF 314
>Hs19743914 [T] KOG0793 Protein tyrosine phosphatase
Length = 986
Score = 62.8 bits (151), Expect = 3e-10
Identities = 52/194 (26%), Positives = 83/194 (41%), Gaps = 32/194 (16%)
Query: 6 ISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQN 65
+ +VM+TPL E G +CY YWP D + + N+++++
Sbjct: 811 VVIVMLTPLAENGVRQCYHYWP--------------------DEGSNLYHIYEVNLVSEH 850
Query: 66 --CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN 123
C+ + V LK + +TV F++ W D P L + V+ +
Sbjct: 851 IWCEDFLVRSFYLKNLQTN-ETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRS 909
Query: 124 -PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
PI VHCS G GRSGTY+ +D ++ K K + I I + LR QR V+
Sbjct: 910 CPIIVHCSDGAGRSGTYVLIDMVLNKMA--KGAKEID------IAATLEHLRDQRPGMVQ 961
Query: 183 SPQQYLFIYHAAKQ 196
+ +Q+ F A +
Sbjct: 962 TKEQFEFALTAVAE 975
>Hs19743912 [T] KOG0793 Protein tyrosine phosphatase
Length = 998
Score = 62.8 bits (151), Expect = 3e-10
Identities = 52/194 (26%), Positives = 83/194 (41%), Gaps = 32/194 (16%)
Query: 6 ISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQN 65
+ +VM+TPL E G +CY YWP D + + N+++++
Sbjct: 823 VVIVMLTPLAENGVRQCYHYWP--------------------DEGSNLYHIYEVNLVSEH 862
Query: 66 --CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN 123
C+ + V LK + +TV F++ W D P L + V+ +
Sbjct: 863 IWCEDFLVRSFYLKNLQTN-ETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRS 921
Query: 124 -PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
PI VHCS G GRSGTY+ +D ++ K K + I I + LR QR V+
Sbjct: 922 CPIIVHCSDGAGRSGTYVLIDMVLNKMA--KGAKEID------IAATLEHLRDQRPGMVQ 973
Query: 183 SPQQYLFIYHAAKQ 196
+ +Q+ F A +
Sbjct: 974 TKEQFEFALTAVAE 987
>Hs11386149 [T] KOG0793 Protein tyrosine phosphatase
Length = 1015
Score = 62.8 bits (151), Expect = 3e-10
Identities = 52/194 (26%), Positives = 83/194 (41%), Gaps = 32/194 (16%)
Query: 6 ISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQN 65
+ +VM+TPL E G +CY YWP D + + N+++++
Sbjct: 840 VVIVMLTPLAENGVRQCYHYWP--------------------DEGSNLYHIYEVNLVSEH 879
Query: 66 --CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN 123
C+ + V LK + +TV F++ W D P L + V+ +
Sbjct: 880 IWCEDFLVRSFYLKNLQTN-ETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRS 938
Query: 124 -PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
PI VHCS G GRSGTY+ +D ++ K K + I I + LR QR V+
Sbjct: 939 CPIIVHCSDGAGRSGTYVLIDMVLNKMA--KGAKEID------IAATLEHLRDQRPGMVQ 990
Query: 183 SPQQYLFIYHAAKQ 196
+ +Q+ F A +
Sbjct: 991 TKEQFEFALTAVAE 1004
>CE14225 [T] KOG0789 Protein tyrosine phosphatase
Length = 365
Score = 62.8 bits (151), Expect = 3e-10
Identities = 53/184 (28%), Positives = 88/184 (47%), Gaps = 35/184 (19%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
VVM+ ++E G++KC YWP ET I G ++ A +E QN
Sbjct: 184 VVMLCNIMECGKKKCEQYWP----ETADGQMILMDGKLTVKIAEPAKEVE------QNIL 233
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
++ I K + +F H+ + W D PE L + T+S PI V
Sbjct: 234 LMKITVIDDKGTSHNF-----EHWQWKAWPDRGVPE-------LPMALKTAS----PIVV 277
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HCSAG+GR+G+ + L+ + K + +K +++ IV+++R QR +V++ QY
Sbjct: 278 HCSAGIGRTGSIVGLEIALVK---------FCAGEKVVLKDIVKEIRNQRHGSVQTDAQY 328
Query: 188 LFIY 191
LF++
Sbjct: 329 LFMH 332
>Hs4506313 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1118
Score = 62.4 bits (150), Expect = 4e-10
Identities = 50/192 (26%), Positives = 87/192 (45%), Gaps = 31/192 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
++ ++VM+T +E GR KC YWP P H L E V+
Sbjct: 912 QQSHTLVMLTNCMEAGRVKCEHYWPLD--------------SQPCTHGHLRVTLVGEEVM 957
Query: 63 TQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDM---ERPEEIGPLHHLMKHVHTSS 119
+++TV ++LL + + +V F+Y W D P+ + +++ +
Sbjct: 958 ----ENWTVRELLLLQVEEQKTL-SVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQT 1012
Query: 120 DPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
P VHCSAGVGR+GT +ALD L+ + + + + + VR++R R
Sbjct: 1013 MEGGPPIVHCSAGVGRTGTLIALDVLLRQ---LQSEGLLGPF------SFVRKMRESRPL 1063
Query: 180 TVESPQQYLFIY 191
V++ QY+F++
Sbjct: 1064 MVQTEAQYVFLH 1075
>CE26346 [T] KOG0789 Protein tyrosine phosphatase
Length = 289
Score = 62.4 bits (150), Expect = 4e-10
Identities = 57/194 (29%), Positives = 92/194 (47%), Gaps = 40/194 (20%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVL 62
E ++VM+ E REKC Y+PR+ + + K S ED
Sbjct: 96 ENTTAIVMLCQFTETNREKCAEYFPRNAHCCL---QFDKMSVSYEDS------------- 139
Query: 63 TQNCQHYTVSKILLKPS-DPSFPVKT--VNHFYYDQWSDMERPEEIGPLHHLMKHVHTSS 119
TV+K L+ + S+ +T + H+ + +W D + P + +++ + S
Sbjct: 140 -------TVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS 192
Query: 120 DPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHS-YDKDLIEQIVRQLR-TQR 177
P P+ +HCSAGVGRSGT MA++ + + IHS + I+QIV LR T R
Sbjct: 193 TP--PV-IHCSAGVGRSGTLMAVEIAL---------QSIHSHFTLPDIKQIVSHLRVTGR 240
Query: 178 LKTVESPQQYLFIY 191
+V++ QQY+ I+
Sbjct: 241 AASVQTLQQYMLIW 254
>CE10628 [T] KOG0789 Protein tyrosine phosphatase
Length = 374
Score = 62.4 bits (150), Expect = 4e-10
Identities = 45/192 (23%), Positives = 91/192 (46%), Gaps = 23/192 (11%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
S++M+ ++E R KC YWP +T + T +++ G L+ +
Sbjct: 158 SIIMLCKVIELARVKCEQYWPAVEGQTNTYVSKGHT----ITINNLGVG-----TLSPDD 208
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIF 126
V+ + L + + +++ H+ + W D P +L++ V+ + NP+
Sbjct: 209 DFINVTNLELVWAGKT---RSITHYQWTNWPDHGAPPINMGAINLIEAVNYDT---NPVV 262
Query: 127 VHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQ 186
VHCSAGVGRSGT + + ++ D+ I + ++++V ++R QR +++ Q
Sbjct: 263 VHCSAGVGRSGTIVGISLIM--------DKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQ 314
Query: 187 YLFIYHAAKQIF 198
Y++I+ + F
Sbjct: 315 YMYIHRVLLEYF 326
>Hs4885567 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 1187
Score = 62.0 bits (149), Expect = 5e-10
Identities = 58/216 (26%), Positives = 95/216 (43%), Gaps = 45/216 (20%)
Query: 3 EEDISVV-MVTPLVEQGREKCYAYWPRSLNETMFSPAIQK----TGPSPEDVSHFAFGLE 57
E+ ++V+ MVT E GR K + YWP+ L S K T + V + GL+
Sbjct: 999 EQGVNVIAMVTAEEEGGRTKSHRYWPK-LGSKHSSATYGKFKVTTKFRTDSVCYATTGLK 1057
Query: 58 LENVLTQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHV-- 115
++++L S +TV H Y W D PE++ ++ +
Sbjct: 1058 VKHLL-------------------SGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQS 1098
Query: 116 ---HTSS------DPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLI 166
HT+S + PI VHCSAGVGR+G + L L+ ++ +K +
Sbjct: 1099 VRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGV-LILSELMIYCLEHN--------EKVEV 1149
Query: 167 EQIVRQLRTQRLKTVESPQQYLFIYHAAKQIFRYTR 202
++R LR QR+ +++ QY F+Y Q + +R
Sbjct: 1150 PMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSR 1185
>CE16864 [T] KOG0789 Protein tyrosine phosphatase
Length = 374
Score = 62.0 bits (149), Expect = 5e-10
Identities = 49/193 (25%), Positives = 84/193 (43%), Gaps = 30/193 (15%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+ +E G+ KC YWP ++ E G+ +ENV
Sbjct: 177 IVMLCKTIETGKYKCAQYWPLAMGEK----------------KEVKGGIVVENVSGTKPM 220
Query: 68 HYTVSKILLKPSDPSFPVK--TVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPI 125
++I + SF + +V H ++ W D P L+ V S P I
Sbjct: 221 DRD-AEIQITTLQVSFGDQKMSVRHLHWSDWPDRGVPPCKLTSLELLSAVRGSRVP---I 276
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
VHCSAG+GR+GT +A+++++ + + K + +V+ LR QR ++++
Sbjct: 277 VVHCSAGIGRTGTIVAIEYILERIAENK--------QCPPMPDLVKSLRDQRAYSIQTDM 328
Query: 186 QYLFIYHAAKQIF 198
QYL+I+ F
Sbjct: 329 QYLYIHRVMLNYF 341
>At1g71860 [T] KOG0789 Protein tyrosine phosphatase
Length = 340
Score = 61.6 bits (148), Expect = 7e-10
Identities = 34/109 (31%), Positives = 56/109 (51%), Gaps = 11/109 (10%)
Query: 87 TVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFVHCSAGVGRSGTYMALDHLI 146
+V H Y +W D P++ + ++K ++ PI VHCSAG+GR+GTY A+ + I
Sbjct: 223 SVLHIQYPEWPDHGVPKDTVAVREILKRLYQVPPSLGPIIVHCSAGIGRTGTYCAIHNTI 282
Query: 147 TKTIDFKDDEFIHSYDKDLIE--QIVRQLRTQRLKTVESPQQYLFIYHA 193
+ I + D ++ + V R QR+ V++ QY F Y+A
Sbjct: 283 QR---------ILAGDMSALDLAKTVALFRKQRIGMVQTMDQYFFCYNA 322
>CE27280 [T] KOG0789 Protein tyrosine phosphatase
Length = 352
Score = 61.2 bits (147), Expect = 9e-10
Identities = 48/189 (25%), Positives = 81/189 (42%), Gaps = 30/189 (15%)
Query: 7 SVVMVTPLVEQGREKCYAYWPR-SLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQN 65
S++M+ +E+GR KC YWP + ET + G S ++ E+ N+
Sbjct: 155 SILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESSDE-------FEICNLAVT- 206
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPI 125
+ + + + VN + W D P+E H + + P
Sbjct: 207 ---FVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDE---KCHTVPQRLLAQVRHGPC 260
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDL---IEQIVRQLRTQRLKTVE 182
VHCSAG+GR+G +AL+ K D+ L E+I+ +LR QR + ++
Sbjct: 261 VVHCSAGIGRTGCVVALEFAYNK------------LDRGLKVDFEEIITELRKQRAQCIQ 308
Query: 183 SPQQYLFIY 191
+ QYL+I+
Sbjct: 309 TEIQYLYIH 317
>CE15324 [T] KOG0789 Protein tyrosine phosphatase
Length = 483
Score = 60.8 bits (146), Expect = 1e-09
Identities = 50/184 (27%), Positives = 86/184 (46%), Gaps = 27/184 (14%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+ LVE+G+ K Y+P + +T + ++++ L +
Sbjct: 290 IVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESR--------VDIDKTLVMSTM 341
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFV 127
+ KP D + VK V H ++ W D P+ L+ V + PI V
Sbjct: 342 RIS------KPGDNAV-VKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT---KPIVV 391
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HCSAGVGR+GT +AL +I ++I D FI + +++ +LR +R + V++ QY
Sbjct: 392 HCSAGVGRTGT-LALILIILESICLPD--FIG------VPRLLAKLREERFRAVQTEMQY 442
Query: 188 LFIY 191
L+ +
Sbjct: 443 LYAH 446
>7292074 [T] KOG0789 Protein tyrosine phosphatase
Length = 548
Score = 60.5 bits (145), Expect = 2e-09
Identities = 49/190 (25%), Positives = 83/190 (42%), Gaps = 26/190 (13%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
+V+M+ L+E+ + KC+ YWP NE A++ + H +EL V +
Sbjct: 126 AVLMLNKLMEKKQIKCHLYWP---NEMGADKALK--------LPHVKLTVEL--VRLETY 172
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTS---SDPFN 123
Q++ L + + V F+Y W D P ++ V S S
Sbjct: 173 QNFVRRWFKLTDLETQ-QSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVG 231
Query: 124 PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVES 183
P VHCSAG+GRSGT+ +D + I Y + + +++ +LR+ R+ +++
Sbjct: 232 PAVVHCSAGIGRSGTFCLVDCCLV---------LIDKYGECNVSKVLCELRSYRMGLIQT 282
Query: 184 PQQYLFIYHA 193
Q F Y A
Sbjct: 283 ADQLDFSYQA 292
>CE03652 [T] KOG4228 Protein tyrosine phosphatase
Length = 711
Score = 58.5 bits (140), Expect = 6e-09
Identities = 52/199 (26%), Positives = 84/199 (42%), Gaps = 46/199 (23%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFG-LELENVLTQNC 66
+VM+T + + R C YWP ++ F F +E+E +
Sbjct: 154 IVMLTKVFDFMRVMCLQYWP---------------------LTKFQFREIEVETTEVKTY 192
Query: 67 QHYTVSKILLKPSDP-SFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT--SSDPFN 123
H+ + L + P S + V HF++ +W +++ I L + V +P
Sbjct: 193 SHFVIRTFKLTRTTPESIETRIVKHFHFTEW-ELDSFPYISAFIELRRRVRQFMEKNPVE 251
Query: 124 -PIFVHCSAGVGRSGTYMALD---HLITKT--IDFKDDEFIHSYDKDLIEQIVRQLRTQR 177
P+ VHCS G GRSG ++ALD L+ KT +DF Y K L+ R
Sbjct: 252 APMVVHCSNGAGRSGAFLALDANLELMKKTGQLDF------FEYAKTLV--------NSR 297
Query: 178 LKTVESPQQYLFIYHAAKQ 196
++S +QY+FIY +
Sbjct: 298 PHLIDSVEQYMFIYEVLSE 316
>Hs17434186 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 477
Score = 58.2 bits (139), Expect = 8e-09
Identities = 47/191 (24%), Positives = 82/191 (42%), Gaps = 35/191 (18%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM T VE+G+ KC YWP A+++ G + + NV
Sbjct: 237 IVMTTKEVERGKSKCVKYWPDEY-------ALKEYGI-----------VHVRNVKESTTH 278
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF---NP 124
Y + K+ L + V ++ W P + + H + VH +
Sbjct: 279 DYKLRKLKLSKIGQGNMERMVWQYHLWTWLYHGVPCDPKGMLHFLDEVHHKQESIMDAGL 338
Query: 125 IFVHCSAGVGRSGTYMALDHLI----TKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
+ V CSAG+G++GT++ +D LI K +D + D + + ++ +R+QR +
Sbjct: 339 VVVPCSAGIGQTGTFIVIDILIDIIREKGVDCEID----------VPKTIQMVRSQRSEM 388
Query: 181 VESPQQYLFIY 191
V++ QY FIY
Sbjct: 389 VQTEAQYRFIY 399
>Hs18375655 [T] KOG0789 Protein tyrosine phosphatase
Length = 460
Score = 57.4 bits (137), Expect = 1e-08
Identities = 50/199 (25%), Positives = 80/199 (40%), Gaps = 41/199 (20%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
++M +E GR++C YW + P F L E L ++
Sbjct: 127 ILMACREIENGRKRCERYWAQE--------------QEPLQTGLFCITLIKEKWLNEDIM 172
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT--SSDPFNPI 125
T+ K S ++V Y W D P + +++ S P P+
Sbjct: 173 LRTLKVTFQKES------RSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGP-EPL 225
Query: 126 FVHCSAGVGRSGTYMALDH----LITKTI--DFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
VHCSAG GR+G +D+ L+T+ I DF + +V ++R QR
Sbjct: 226 CVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFS------------LFDVVLKMRKQRPA 273
Query: 180 TVESPQQYLFIYHAAKQIF 198
V++ +QY F+YH Q+F
Sbjct: 274 AVQTEEQYRFLYHTVAQMF 292
>Hs4506321 [T] KOG0793 Protein tyrosine phosphatase
Length = 979
Score = 56.6 bits (135), Expect = 2e-08
Identities = 51/190 (26%), Positives = 79/190 (40%), Gaps = 28/190 (14%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
+VM+TPLVE G ++C YWP G S V + L E++ C+
Sbjct: 806 IVMLTPLVEDGVKQCDRYWPDE-------------GASLYHV--YEVNLVSEHIW---CE 847
Query: 68 HYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN-PIF 126
+ V LK +T+ F++ W P PL + V+ + PI
Sbjct: 848 DFLVRSFYLKNVQTQ-ETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPII 906
Query: 127 VHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQ 186
VHCS G GR+GTY+ +D ++ + + + D I + +R QR V S Q
Sbjct: 907 VHCSDGAGRTGTYILIDMVLNRMA-----KGVKEID---IAATLEHVRDQRPGLVRSKDQ 958
Query: 187 YLFIYHAAKQ 196
+ F A +
Sbjct: 959 FEFALTAVAE 968
>CE20702 [T] KOG0789 Protein tyrosine phosphatase
Length = 446
Score = 56.2 bits (134), Expect = 3e-08
Identities = 46/192 (23%), Positives = 83/192 (42%), Gaps = 31/192 (16%)
Query: 3 EEDISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENV- 61
E+ +VVM+ E G +KC Y P S +++SH + +
Sbjct: 205 EKAPAVVMICDWEEDGIQKCSRYIP-----------------SEDNISHVCGIYRITKID 247
Query: 62 -LTQNCQHYTVSKILLKPSDPSF--PVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTS 118
+T + + +D S P V H+++ +W D P + L+K +
Sbjct: 248 QMTMVYADVALQSFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP 307
Query: 119 SDPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRL 178
P P+ +HCSAG+GR+ T + +D+ ++ I + + IVR++R R
Sbjct: 308 KRPGPPV-IHCSAGIGRTATLIGVDY---------GNQRIGEVGEMNVLDIVREMRQMRD 357
Query: 179 KTVESPQQYLFI 190
K V+S Q++F+
Sbjct: 358 KAVQSHHQFIFM 369
>YOR208w [T] KOG0789 Protein tyrosine phosphatase
Length = 750
Score = 55.8 bits (133), Expect = 4e-08
Identities = 30/87 (34%), Positives = 49/87 (55%), Gaps = 3/87 (3%)
Query: 115 VHTSSDPFNPIFVHCSAGVGRSGTYMALDHL---ITKTIDFKDDEFIHSYDKDLIEQIVR 171
+H + +P+ VHCSAG GR+G ++ LD L ++ T + + + + +DLI IV
Sbjct: 652 LHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSNKIDVWNMTQDLIFIIVN 711
Query: 172 QLRTQRLKTVESPQQYLFIYHAAKQIF 198
+LR QR+ V++ QY+ Y A F
Sbjct: 712 ELRKQRISMVQNLTQYIACYEALLNYF 738
>CE15349 [T] KOG0789 Protein tyrosine phosphatase
Length = 344
Score = 55.5 bits (132), Expect = 5e-08
Identities = 42/192 (21%), Positives = 86/192 (43%), Gaps = 21/192 (10%)
Query: 1 MPEEDISVVMVTPLVEQGREKCYAYWPRSLNETM-FSPAIQKTGPSPEDVSHFAFGLELE 59
+ E+ S+ M+ ++E+G +KC Y+ + F K E F +
Sbjct: 140 LQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIVKFESTGKMKFEKNTD 199
Query: 60 NVLTQNCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSS 119
+T+ +TV P + V +++ W D P + L+ S
Sbjct: 200 AKITETV--FTVE-------GPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK 250
Query: 120 DPFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLK 179
P VHCSAG+GR+G+ + +++++ D+ + + ++I++++R QR
Sbjct: 251 ---GPTVVHCSAGIGRTGSVVMIEYIL--------DQLLGGQQIEETDKILQKIREQRNN 299
Query: 180 TVESPQQYLFIY 191
++++ QQYLF++
Sbjct: 300 SIQTDQQYLFVH 311
>CE25558 [T] KOG0789 Protein tyrosine phosphatase
Length = 557
Score = 55.1 bits (131), Expect = 7e-08
Identities = 45/198 (22%), Positives = 86/198 (42%), Gaps = 25/198 (12%)
Query: 7 SVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNC 66
S++M+ VE G EKC Y +++ + ++ E + G + ++ +T
Sbjct: 263 SIIMLCGFVEDGSEKCAKY----ISDIVGFVNLEDHRVYTEYCTEIEIGGKSKDKIT--- 315
Query: 67 QHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIF 126
+ V K+++K + +NH+ + W D P+ L+ V P+
Sbjct: 316 --HRVLKVVVKATGQE---SKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK---KPVI 367
Query: 127 VHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQ 186
HCSAGVGR+GT ++ +I + K ++ LR R ++V++ Q
Sbjct: 368 AHCSAGVGRTGTLALIESMIAA---------LRHPRKQNVKDSFVLLRKDRARSVQTFPQ 418
Query: 187 YLFIYHAAKQIFRYTRGL 204
Y++ + F Y++GL
Sbjct: 419 YVYALRCVLE-FLYSKGL 435
>CE03852 [T] KOG0789 Protein tyrosine phosphatase
Length = 198
Score = 53.9 bits (128), Expect = 1e-07
Identities = 38/115 (33%), Positives = 62/115 (53%), Gaps = 13/115 (11%)
Query: 77 KPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPIFVHCSAGVGRS 136
KP D + VK V H ++ W D P+ L+ V + + PI VHCSAGVGR+
Sbjct: 60 KPGDNAV-VKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKSCT---KPIVVHCSAGVGRT 115
Query: 137 GTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQYLFIY 191
GT +AL +I ++I D FI + +++ +LR +R + +++ QYL+ +
Sbjct: 116 GT-LALILIILESICLPD--FIG------VPRLLAKLREERFRAIQTEVQYLYAH 161
>CE18278 [T] KOG0789 Protein tyrosine phosphatase
Length = 591
Score = 53.5 bits (127), Expect = 2e-07
Identities = 45/183 (24%), Positives = 77/183 (41%), Gaps = 33/183 (18%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPA--IQKTGPSPEDVSHFAFGLELENVLTQN 65
+VM+ ++E G+ KC Y+P E M A I + +D + L + NV
Sbjct: 217 IVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDDKDANIIKRTLSVRNV-DNG 275
Query: 66 CQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFNPI 125
+H + H + W D P L ++ V T+S P+
Sbjct: 276 KEH------------------ILKHLHTKSWPDRCVPNSTMALLRMLYIVRTAS---GPV 314
Query: 126 FVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQ 185
VHCSAG+GR+GT++A++ + D K+ + + + R LR R +++
Sbjct: 315 TVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGT---------CRALRNSRAGSIQVDI 365
Query: 186 QYL 188
QY+
Sbjct: 366 QYM 368
>CE10618 [T] KOG0789 Protein tyrosine phosphatase
Length = 130
Score = 50.8 bits (120), Expect = 1e-06
Identities = 24/76 (31%), Positives = 44/76 (57%), Gaps = 8/76 (10%)
Query: 123 NPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
NP+ VHCSAGVGRSGT + + ++ D+ I + ++++V ++R QR ++
Sbjct: 15 NPVVVHCSAGVGRSGTIVGISLIM--------DKMIQGINCKDMKKLVEEIRNQRHYAIQ 66
Query: 183 SPQQYLFIYHAAKQIF 198
+ QY++I+ + F
Sbjct: 67 TEAQYMYIHRVLLEYF 82
>CE04159 [T] KOG0789 Protein tyrosine phosphatase
Length = 288
Score = 49.7 bits (117), Expect = 3e-06
Identities = 21/78 (26%), Positives = 46/78 (58%), Gaps = 8/78 (10%)
Query: 121 PFNPIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKT 180
P PI VHCSAG+GR+G+ + ++++ ++ ++ + ++I++++R QR +
Sbjct: 193 PGGPIAVHCSAGIGRTGSVVMIEYMC--------EQLLNGNQIEETDKILQKIREQRNNS 244
Query: 181 VESPQQYLFIYHAAKQIF 198
+++ QYLF++ F
Sbjct: 245 IQTDHQYLFVHQVMMNFF 262
>7296136 [T] KOG0793 Protein tyrosine phosphatase
Length = 1180
Score = 48.9 bits (115), Expect = 5e-06
Identities = 52/194 (26%), Positives = 76/194 (38%), Gaps = 31/194 (15%)
Query: 6 ISVVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSH-FAFGLELENVLTQ 64
+ +V + L E G C YWP E V H + L E++
Sbjct: 916 VVIVALCRLQENGEVACARYWPEEGAE----------------VYHIYEVHLVSEHIW-- 957
Query: 65 NCQHYTVSKILLKPSDPSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPFN- 123
C Y V LK S +TV F++ W M P + L + V+ S
Sbjct: 958 -CDDYLVRSFYLKNLRTS-ETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRS 1015
Query: 124 -PIFVHCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVE 182
PI VH SAG GR+G Y+ LD ++ + ++ D I + LR QR V
Sbjct: 1016 CPIVVHGSAGAGRTGVYILLDLVLERM-----NKGAREID---IAATLEHLRDQRAGVVA 1067
Query: 183 SPQQYLFIYHAAKQ 196
+ QQ+ F+ A +
Sbjct: 1068 TRQQFEFVLMAVAE 1081
>CE12028 [T] KOG0789 Protein tyrosine phosphatase
Length = 443
Score = 48.1 bits (113), Expect = 8e-06
Identities = 47/204 (23%), Positives = 81/204 (39%), Gaps = 47/204 (23%)
Query: 8 VVMVTPLVEQGREKCYAYWPRSLNETMFSPAIQKTGPSPEDVSHFAFGLELENVLTQNCQ 67
V M+ E+G EKC +Y+P ++K G NV T N Q
Sbjct: 148 VAMLCDFNEEGVEKCSSYFP-----------LEKDGKQK---------FHNVNVCTTNVQ 187
Query: 68 HYTVSKILLKPSDPSF-----PVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHTSSDPF 122
H + +L S+ TV H+ Y W + PE + ++ + S
Sbjct: 188 HPSADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNSKS-- 245
Query: 123 NPIFVHCSAGVGRSGTYMALD---HLIT---KTIDFKDDEFIH-----------SYDKDL 165
+ VHCS G+GRS +++ + H + + DF EF++ + + D
Sbjct: 246 --LVVHCSNGIGRSAAFVSWELCYHFVPVNFEICDFSVAEFVYQKMIRSLDTTSTVNLDF 303
Query: 166 IEQIVRQLRTQRLKTVESPQQYLF 189
+ ++ +LR R + + +P Q F
Sbjct: 304 L-SLLTELRHSRPRAIHTPMQLAF 326
>7297098 [T] KOG0792 Protein tyrosine phosphatase PTPMEG contains FERM domain
Length = 1252
Score = 48.1 bits (113), Expect = 8e-06
Identities = 36/135 (26%), Positives = 63/135 (46%), Gaps = 24/135 (17%)
Query: 81 PSFPVKTVNHFYYDQWSDMERPEEIGPLHHLMKHVHT-------------SSDPFNPIFV 127
PS ++V + Y W++ P ++ ++ +++ +++P P+ +
Sbjct: 1127 PSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNP--PVLL 1184
Query: 128 HCSAGVGRSGTYMALDHLITKTIDFKDDEFIHSYDKDLIEQIVRQLRTQRLKTVESPQQY 187
HC G GRSG + D L+ T+D H+ D D I +++ QLR QR + S QY
Sbjct: 1185 HCLEGGGRSGVTLTAD-LLLYTLD-------HNEDLD-IPRVIGQLRHQRDSIIPSLAQY 1235
Query: 188 LFIYHAAKQIFRYTR 202
FIY+ + TR
Sbjct: 1236 KFIYNLLITYLKRTR 1250
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.137 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,322,546
Number of Sequences: 60738
Number of extensions: 586374
Number of successful extensions: 1909
Number of sequences better than 1.0e-05: 114
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 1600
Number of HSP's gapped (non-prelim): 176
length of query: 204
length of database: 30,389,216
effective HSP length: 101
effective length of query: 103
effective length of database: 24,254,678
effective search space: 2498231834
effective search space used: 2498231834
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)