ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV4787 good A KOG3322 RNA processing and modification Ribonucleases P/MRP protein subunit
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV4787 1637541 1639991 817
(817 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL221c [A] KOG3322 Ribonucleases P/MRP protein subunit 702 0.0
SPAC25B8.16 [A] KOG3322 Ribonucleases P/MRP protein subunit 173 8e-43
CE24787 [A] KOG3322 Ribonucleases P/MRP protein subunit 67 1e-10
Hs17467208 [A] KOG3322 Ribonucleases P/MRP protein subunit 60 1e-08
7290599 [A] KOG3322 Ribonucleases P/MRP protein subunit 60 1e-08
>YNL221c [A] KOG3322 Ribonucleases P/MRP protein subunit
Length = 875
Score = 702 bits (1813), Expect = 0.0
Identities = 376/866 (43%), Positives = 540/866 (61%), Gaps = 55/866 (6%)
Query: 4 KQFTKNQQFKRERVRNARQIRSEASSAN------PGEFSESGSVLNIPSFVSSREYEXXX 57
K KNQ KR R+RNAR IR+EA +A+ P + SESGS LN+ F+SSR++E
Sbjct: 13 KVLNKNQLLKRNRIRNARSIRAEAVAASSTKTGTPSDLSESGSKLNVDQFISSRQFEVKQ 72
Query: 58 XXXXXXXXXXXXXTRVFQALPRSLRRRTASHNVKRIPKRLRNKALKEMQKSQQQFTQGTR 117
TR+FQALPR LRRRTASHNV+RIPKR+RN+AL+EM+KS QQ
Sbjct: 73 LQLAMHNSKAASSTRIFQALPRKLRRRTASHNVRRIPKRMRNRALREMRKSDQQDVLKGS 132
Query: 118 HLFEKRKHGLSSRKIYRAKMMVNLLRLASKANSMKLRLPESLTAGNRQLRSKIRLLQKQL 177
++ HGL+++++Y+A+M + LLRLASK+ SMKL +P +T+ N +R KI+ L++ +
Sbjct: 133 SASSRKAHGLNAKQLYKARMSIKLLRLASKSTSMKLSMPPEVTSSNCHVRQKIKTLKRMI 192
Query: 178 RNSK--SEKISQLNNQLGSYDSTGHNKPANRPIGRAKYMKRQKDFVWLPTHLWNAKRSHM 235
+ S + I LNN++GSYD TG N+ A P GR KY KRQK F WLPTH+WNAKRSHM
Sbjct: 193 KESSTANPNIKLLNNRMGSYDCTGVNELAPIPKGRVKYTKRQKHFAWLPTHIWNAKRSHM 252
Query: 236 FKRWGFHLPWSPTQKNFRLTHRLTANVASSNGAMACDTSYMGDMIV----SCSDHEKLKD 291
KRWG+ + W+PTQK F+LTHRL + SS+GA+ D+SY+G +IV + S+ + LK
Sbjct: 253 MKRWGYQMVWAPTQKCFKLTHRLGGDTCSSDGALCMDSSYIGTIIVKDKSNDSEGDFLKS 312
Query: 292 VIKQLTNGRACLPKYLKRQ-LFKGLLYF--------GTECVGPCNVLWFNPKCVLIRLHP 342
+I +LT RA L KY + Q LF+GL+Y T+ +GPC+V W +IRLHP
Sbjct: 313 IIGKLTAERANLRKYREGQVLFQGLIYSFNEENGEDSTKPLGPCDVFWVQKDTAIIRLHP 372
Query: 343 SIYLQVFSKLVSCLNLKEFSVQDCQFSLGSITISGGKSLYALSQILRSTSDSTSYKQFQK 402
SIY QVF+ L+ + ++ +VQDC++SL S+T+ G K+L +L+ LRST S S++QF+
Sbjct: 373 SIYTQVFNILLQ--HKEKLTVQDCRYSLASVTLKGAKALESLASCLRSTEYSKSFEQFKM 430
Query: 403 ISRITDSTVLPEKTMFAFEAMDPRFLSNPKPCSHS--TPISTEHLLTFSDQLPETELSEV 460
+S ITD LP++ FAFEA+DPR L+ PK + S ++++ +L+ + P+ E++ V
Sbjct: 431 VSMITDHNALPQRCTFAFEAIDPRHLAAPKKLNDSQRKTVNSDDILSLHENYPQDEINAV 490
Query: 461 LCKLASSSERNNSYNNQQTLKQLAX---XXXXXXXXXXXXXMIPLKETDS-RIPLLLMR- 515
+L R SYNNQ TLK+++ +P KE+D IPL+++R
Sbjct: 491 FNELCDPESRTQSYNNQNTLKEISARRYKLLTATPNSINKTTVPFKESDDPSIPLVIIRR 550
Query: 516 -ESQHWVLILPWFWVLPFWYQLNKVSGVYHMGLKQFQQQSFEQKTLNFPDDYPFTAVGYD 574
+++ W+++LPWFW+LP W+ LN++ +YH+GL+QFQQ +E K L FPDDYPFT +GY
Sbjct: 551 LKTRDWIVVLPWFWLLPLWHLLNRIPRMYHIGLRQFQQIQYENKQLYFPDDYPFTQLGYI 610
Query: 575 EDTLYKSEVLHHLWSRKPEAKRINYVKLGLLH--KETIIKGELGLWFSCDWNLLRIFQNG 632
E++ YK E W RKP KRIN+ K+ +H K GE+G +FS DW L+I +NG
Sbjct: 611 ENSFYKKEASKTKWDRKPMGKRINFEKIKDIHNTKLPAYSGEIGDFFSSDWRFLQILRNG 670
Query: 633 LK--SKGFRENDFADQNRTSTFNIDSGVMKIQYIVDLL---KLYEKNKQELSCPVE---- 683
+ + + + D +T FN GV I + D+L K YE + +S +E
Sbjct: 671 IDYLQRNDKTLELMDSKKTGQFNA-QGVRDINCVNDVLEFCKDYEAKTKAMSLSIEENIP 729
Query: 684 ---LYNGKVQ-------EIDEECIATSRLP--IIPVSCSIIQRGHPKDHARIYKIPDTDS 731
N K Q ++ + + P II VSC++++RGHPKD+ARIY++P+ D
Sbjct: 730 VALCKNRKCQFRTPDSISVNSSSFSLTFFPRCIIAVSCTLLERGHPKDNARIYQVPEKDL 789
Query: 732 SYWREIAGGTYKSNGKLQHDTKQPVPHCYDLIGFLTSASFHLSDGKGIGTGFISAYSFES 791
+W ++A G Y+ NG+ HD K P+P +DLIGF+TS ++HL+ G G+G GFI ++
Sbjct: 790 EHWLQLAKGVYRPNGRKDHDLKIPLPEVHDLIGFITSGTYHLNCGNGMGIGFIDHHAAIR 849
Query: 792 LTDHYVLIRNCGETTYRLATWKRISV 817
YVLIRN G TYRL W +ISV
Sbjct: 850 QPTRYVLIRNVGTNTYRLGEWSKISV 875
>SPAC25B8.16 [A] KOG3322 Ribonucleases P/MRP protein subunit
Length = 698
Score = 173 bits (439), Expect = 8e-43
Identities = 169/645 (26%), Positives = 265/645 (40%), Gaps = 116/645 (17%)
Query: 8 KNQQFKRERVRNARQIRSEASSANPGEFSESGSVLNIPSFVSSREYEXXXXXXXXXXXXX 67
K KR ++ +AR I E+ + + G +++ F+ SR +E
Sbjct: 11 KGLNVKRSKLADARFIEVESPALSNG-------AVDLKKFIESRSFEITALQDAMKRSKE 63
Query: 68 XXXTRVFQALPRSLRRRTASHNVKRIPKRLRNKALKEMQKSQQQFTQGTRHLFEKRKHGL 127
R FQALPR LRRR ASHN+KRIPK LR++AL EMQ S
Sbjct: 64 SSAQRAFQALPRCLRRRAASHNIKRIPKGLRDRALYEMQLSSSS---------------- 107
Query: 128 SSRKIYRAKMMVNLLRLASKANSMKLRLPESLTAGNRQLRSKIRLLQKQLRNSKSEKISQ 187
LP + ++L+ I+ L+++L S K
Sbjct: 108 --------------------------TLP--IAPSRQRLKRFIKRLRRKLAKSGETKAID 139
Query: 188 LNNQLGSYDSTGHNKP---ANRPIGRAKYMKRQKDFVWLPTHLWNAKRSHMFKRWGFHLP 244
L + +ST ++ A + R K+ RQ VWLPTHLW KR+HM WG+ +P
Sbjct: 140 STGSLVTDNSTDDSRIPSLAAVKLIRGKFAGRQLRKVWLPTHLWVCKRAHMINAWGYAIP 199
Query: 245 WSPTQKNFRLTHRLTANVASSNGAMACDTSYMGDMIVSCSDHEKLKDVI-KQLTNGRACL 303
PT+K++R THR A A+A D SY +S +E LK+ NG
Sbjct: 200 EKPTEKSYRPTHR----AAFRKDAIAFDMSYEPLFCIS-GPYEALKEKFGNSFANGLP-- 252
Query: 304 PKYLKRQ------LFKGLLYFGTECVGPCNVLWFNP--------------KCV--LIRLH 341
P +L L K ++ E + PC + W NP +CV +IRLH
Sbjct: 253 PVFLNSSRSFTSYLVKSDIH---ELICPCFLQWNNPTEDDKKQIPVKNPTECVQLVIRLH 309
Query: 342 PSIYLQVFSKLVSCLNLKE-FSVQDCQFSLGSITISGGKSLYALSQILRSTSDSTSYKQF 400
PS +LQ ++ L L + ++ D + L S I G S L ++ + K +
Sbjct: 310 PSAFLQAWNYLSGIAVLDDRIAMHDWRLDLASFDIHGPDSNIMLHKVFDDVELDEAGKVW 369
Query: 401 QKISRITDSTVLPEKTMFAFEAMDPRFLSNPKPCSHSTPISTEHLLTFSDQLPETELSEV 460
Q IS + S LP + +A+ ++T S++ ++ L
Sbjct: 370 QSISNYS-SACLPMGASISVKAL----------------VNTRCDKNLSEKGEKSLLDSA 412
Query: 461 LCKLASSSERNNSYNNQQTLKQLAXXXXXXXXXXXXXXMIPLKETDSRIPLLLMRESQHW 520
L +S+ + +++ +++ ++ + + +E
Sbjct: 413 ENSLPASANQYSTHFRYWERQEIPSFAVFENKNRHTHEKKSSEKEVIPVYITYRKEWNGL 472
Query: 521 VLILPWFWVLPFWYQLNKVSGVYHMGLKQFQQQSFEQKTLNFPDDYPFTAVGY--DEDTL 578
+ILPW + W ++ G+ GL+ Q +FE++ FP DYP T G +E+
Sbjct: 473 TVILPWDYAKFVWRKMMYQKGIRFGGLENLHQIAFEKRMPFFPIDYPDTISGQLCEEERK 532
Query: 579 YKSEVLHHLWSRKPEAKRINYVKLGLLHKETIIKGELGLWFSCDW 623
++E W R+P AKR+NY K G E+G F CDW
Sbjct: 533 KRNE---DSWKRRPPAKRVNYQKFGDNF------SEIGNPFCCDW 568
Score = 65.9 bits (159), Expect = 2e-10
Identities = 38/112 (33%), Positives = 61/112 (53%), Gaps = 3/112 (2%)
Query: 702 LPIIPVSCSIIQRGHPKDHARIYKIPDTDSSYWREIAGGTYKSNGKLQHDTKQPVPHCYD 761
L ++ V ++QRG +D ARIY + D + S W+ I YK N ++ P+
Sbjct: 585 LQLVRVQVQLVQRGSLQDRARIYCLSDDELSKWKTII---YKENLTAENLLYPKCPNETA 641
Query: 762 LIGFLTSASFHLSDGKGIGTGFISAYSFESLTDHYVLIRNCGETTYRLATWK 813
+IGF+T+ +F+L+ GK G + A + ++ Y +IRN G + RLA WK
Sbjct: 642 IIGFVTTGNFNLNAGKPSGIANVLAKTIKNEKSGYCIIRNVGCSVPRLAQWK 693
>CE24787 [A] KOG3322 Ribonucleases P/MRP protein subunit
Length = 752
Score = 67.0 bits (162), Expect = 1e-10
Identities = 86/403 (21%), Positives = 155/403 (38%), Gaps = 51/403 (12%)
Query: 221 VWLPTHLWNAKRSHMFKRWGFHLPWSPTQKNFRLTHRLTANVASSNGAMACDTSYMGDMI 280
+WL TH+W+AKR M ++WGF L Q+ FR R S+ + D SY +
Sbjct: 105 IWLSTHVWHAKRFRMIQKWGFKLADRSFQRGFRAVLR-----DSNKNCVIRDRSYYTCVT 159
Query: 281 VSCSD-HEKLKDVIKQLTNGRACLPKYLK-RQLF-KGLLYFGTECVGPCNVLWFNPKCVL 337
+ C+D + K+ ++ G++ + + QL+ G FG +GP + V
Sbjct: 160 IQCTDAYSKISQFSQKGCRGQSSRDEEEECHQLYMPGKYPFG--YIGPARFQRLSGDKVH 217
Query: 338 IRLHPSIYLQVFSKLVSCLNLK-------------EFSVQDCQFSLGSITISGGKSLYAL 384
I +HPS LQ L+ NL+ E V ++ +SG K L L
Sbjct: 218 IWIHPSSKLQFMKALLEYYNLEKQENTEEDLYKNSEIKVSIDAENICRFHLSGPKCLSKL 277
Query: 385 SQILRSTSDSTSYKQFQKISRITDSTVLPEKTMFAFEAM--DPRFLSNPKPCSHSTPIST 442
+R +D + ++DS + + DPR + K ++
Sbjct: 278 RDSIRFVNDEKFSSEHNYFLSVSDSVFQSSRDGEVINLLIEDPRTTWDRKTVLKHKKVNK 337
Query: 443 EHLLTFSDQLPETELSEVLCKLASSSERNNSYNNQQTLKQLAXXXXXXXXXXXXXXMIPL 502
E + E ++ S N + K++A +I
Sbjct: 338 E---------ADNE------RIRVSKFWNKEFREMAIEKRMADSEFHKQNSSKINGVI-- 380
Query: 503 KETDSRIPLLLMRESQHWV------LILPWFWVLPFWYQLNKVSGVYHMGLKQFQQQSFE 556
T++++P++L+ ++ +++P + FW L + GV GL+ E
Sbjct: 381 -STEAKVPIILIIRNEGLKALDGADILIPEPFAKDFWVSLQR-RGVRASGLRDEYAAHLE 438
Query: 557 QKTLNFPDDYPFTAVGYDEDTLYKSEVLHHLWSRKPEAKRINY 599
K L +P D + G + + K E++ + KP +R +
Sbjct: 439 SKALYYPLDDVGSEAGRESELAMKKELIEK-YLGKPHNRRCKH 480
>Hs17467208 [A] KOG3322 Ribonucleases P/MRP protein subunit
Length = 1024
Score = 60.5 bits (145), Expect = 1e-08
Identities = 43/161 (26%), Positives = 78/161 (47%), Gaps = 11/161 (6%)
Query: 134 RAKMMVNLLRLASKANSMKL---RLPESLTAGNRQLRSKIRLLQKQLRNSKSEKISQLNN 190
RA + +L+ ++ +S L LP + R + ++ L ++L+ ++ + +
Sbjct: 111 RAAEISAMLKAVTQKSSNSLVFQTLPRHMR--RRAMSHNVKRLPRRLQEIAQKEAEKAVH 168
Query: 191 QLGSYDSTGHNKPANRPIGRA-KYMKRQKDFVWLPTHLWNAKRSHMFKRWGFHLPWSPTQ 249
Q + +K + R ++ +RQK +WL TH+W+AKR HM K+WG+ L PT
Sbjct: 169 QKKEHSKNKCHKARRCHMNRTLEFNRRQKKNIWLETHIWHAKRFHMVKKWGYCLGERPTV 228
Query: 250 KNFRLTHRLTANVASSNGAMACDTSYMGDMIVSCSDHEKLK 290
K+ R +R A +N + D SY + + + E LK
Sbjct: 229 KSHRACYR-----AMTNRCLLQDLSYYCCLELKGKEEEILK 264
Score = 52.8 bits (125), Expect = 2e-06
Identities = 59/252 (23%), Positives = 98/252 (38%), Gaps = 52/252 (20%)
Query: 400 FQKISRITDSTVLPEKTMFAFEAMDPRF---------LSNPKPCSHSTPISTEHLLTFSD 450
F+ + IT +P T+ DPR L NP+ C + + L
Sbjct: 487 FELLGGITSPAEIPAGTILGLTVGDPRINLPQKKSKALPNPEKCQDNEKVRQLLLEGVPV 546
Query: 451 QLPETEL-SEVLCKLASSSERNNSYNNQQTLKQLAXXXXXXXXXXXXXXMIPLKETDSRI 509
+ + + ++ +CK + ++ ++ N+ + L + L +S+I
Sbjct: 547 ECTHSFIWNQDICKSVTENKISDQDLNRMRSELLVPGS-----------QLILGPHESKI 595
Query: 510 PLLLMRE------------SQHWVLILPWFWVLPFWYQLNKVSGVYHMGLKQFQQQSFEQ 557
P+LL+++ W ++LP W + FW GV GLK+ S +
Sbjct: 596 PILLIQQPGKVTGEDRLGWGSGWDVLLPKGWGMAFWIPFI-YRGVRVGGLKESAVHSQYK 654
Query: 558 KTLNFPDDYPFTAVGYDEDTLYKSEVLHHL---WSRKPEAKRINYVKLGLLHKETIIKGE 614
++ N P D+P G L+ E +L + R+P AKR NYVKLG L
Sbjct: 655 RSPNVPGDFPDCPAGM----LFAEEQAKNLLEKYKRRPPAKRPNYVKLGTLAP------- 703
Query: 615 LGLWFSCDWNLL 626
F C W L
Sbjct: 704 ----FCCPWEQL 711
Score = 50.8 bits (120), Expect = 8e-06
Identities = 24/52 (46%), Positives = 35/52 (67%)
Query: 73 VFQALPRSLRRRTASHNVKRIPKRLRNKALKEMQKSQQQFTQGTRHLFEKRK 124
VFQ LPR +RRR SHNVKR+P+RL+ A KE +K+ Q + +++ K +
Sbjct: 131 VFQTLPRHMRRRAMSHNVKRLPRRLQEIAQKEAEKAVHQKKEHSKNKCHKAR 182
>7290599 [A] KOG3322 Ribonucleases P/MRP protein subunit
Length = 857
Score = 60.5 bits (145), Expect = 1e-08
Identities = 27/66 (40%), Positives = 40/66 (59%), Gaps = 5/66 (7%)
Query: 212 KYMKRQKDFVWLPTHLWNAKRSHMFKRWGFHLPWSPTQKNFRLTHRLTANVASSNGAMAC 271
+Y++RQ+ VWL TH+W+AKR HM RWG LP++ K +R +R AS+ +
Sbjct: 112 EYVRRQRRHVWLETHIWHAKRFHMVDRWGHRLPYASCDKTYRACYR-----ASAEHCLLQ 166
Query: 272 DTSYMG 277
D S+ G
Sbjct: 167 DISFYG 172
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,426,922
Number of Sequences: 60738
Number of extensions: 2101936
Number of successful extensions: 5248
Number of sequences better than 1.0e-05: 5
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 5219
Number of HSP's gapped (non-prelim): 16
length of query: 817
length of database: 30,389,216
effective HSP length: 115
effective length of query: 702
effective length of database: 23,404,346
effective search space: 16429850892
effective search space used: 16429850892
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)