ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV4877 good O KOG3525 Posttranslational modification, protein turnover, chaperones Subtilisin-like proprotein convertase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV4877 1674608 1672341 -756
(756 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL238w [O] KOG3525 Subtilisin-like proprotein convertase 834 0.0
SPAC22E12.09c [O] KOG3525 Subtilisin-like proprotein convertase 456 e-128
Hs20336248 [O] KOG3525 Subtilisin-like proprotein convertase 404 e-112
Hs4505579 [O] KOG3525 Subtilisin-like proprotein convertase 379 e-104
CE17653 [O] KOG3525 Subtilisin-like proprotein convertase 365 e-100
Hs20336242 [O] KOG3525 Subtilisin-like proprotein convertase 360 3e-99
Hs20336244 [O] KOG3526 Subtilisin-like proprotein convertase 357 4e-98
7293216 [O] KOG3525 Subtilisin-like proprotein convertase 348 2e-95
7301334 [O] KOG3525 Subtilisin-like proprotein convertase 347 4e-95
7301335 [O] KOG3525 Subtilisin-like proprotein convertase 345 1e-94
7301492 [O] KOG3526 Subtilisin-like proprotein convertase 342 2e-93
Hs4505577 [O] KOG3525 Subtilisin-like proprotein convertase 338 2e-92
Hs20336184 [O] KOG3525 Subtilisin-like proprotein convertase 338 2e-92
Hs20336182 [O] KOG3525 Subtilisin-like proprotein convertase 338 2e-92
Hs20336180 [O] KOG3525 Subtilisin-like proprotein convertase 338 2e-92
Hs20336190 [O] KOG3525 Subtilisin-like proprotein convertase 335 2e-91
Hs20336188 [O] KOG3525 Subtilisin-like proprotein convertase 335 2e-91
CE08940 [O] KOG3526 Subtilisin-like proprotein convertase 333 4e-91
Hs20336246 [O] KOG3525 Subtilisin-like proprotein convertase 333 6e-91
Hs20336192 [O] KOG3525 Subtilisin-like proprotein convertase 331 2e-90
CE11736 [O] KOG3525 Subtilisin-like proprotein convertase 317 4e-86
CE11734 [O] KOG3525 Subtilisin-like proprotein convertase 317 4e-86
CE11732 [O] KOG3525 Subtilisin-like proprotein convertase 317 4e-86
CE11730 [O] KOG3525 Subtilisin-like proprotein convertase 317 4e-86
CE11728 [O] KOG3525 Subtilisin-like proprotein convertase 317 4e-86
CE17654 [O] KOG3525 Subtilisin-like proprotein convertase 313 8e-85
CE08941 [O] KOG3526 Subtilisin-like proprotein convertase 285 2e-76
CE28554 [O] KOG3525 Subtilisin-like proprotein convertase 255 2e-67
Hs20336186 [O] KOG3525 Subtilisin-like proprotein convertase 255 2e-67
Hs20484562 [O] KOG3525 Subtilisin-like proprotein convertase 72 2e-12
>YNL238w [O] KOG3525 Subtilisin-like proprotein convertase
Length = 814
Score = 834 bits (2155), Expect = 0.0
Identities = 411/759 (54%), Positives = 517/759 (67%), Gaps = 38/759 (5%)
Query: 13 AVSGYGKAMQVPKKDHENRQYFAIESYDDVGNLLAEHSDWSFEHDVRGLANHYVFSKPLQ 72
+ S + Q+P KDH +RQYFA+ES + + L H +W +EHDVRGL NHYVFSK L
Sbjct: 16 STSALVSSQQIPLKDHTSRQYFAVESNETLSRLEEMHPNWKYEHDVRGLPNHYVFSKELL 75
Query: 73 SLGKRDAIDTGYSEN---IIDFHDL-PPVQLHKRLPIG----DSSMEQIQNARILFNISD 124
LGKR +++ +N I+ HDL P L KRLP+ DSS+ ++ A +I+D
Sbjct: 76 KLGKRSSLEELQGDNNDHILSVHDLFPRNDLFKRLPVPAPPMDSSLLPVKEAEDKLSIND 135
Query: 125 PLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGSW 184
PLF++QWHL+NP++PG+D+NV LW NITG GVVAA+VDDGLDYENEDLKDNFC EGSW
Sbjct: 136 PLFERQWHLVNPSFPGSDINVLDLWYNNITGAGVVAAIVDDGLDYENEDLKDNFCAEGSW 195
Query: 185 DFNDNNPLPKPRLKDDYHGTRCAGEIAAFR-NDICGVGVAYNSKVSGIRILSGQITAEDE 243
DFNDN LPKPRL DDYHGTRCAGEIAA + N+ CGVGV YN+K+SGIRILSG IT EDE
Sbjct: 196 DFNDNTNLPKPRLSDDYHGTRCAGEIAAKKGNNFCGVGVGYNAKISGIRILSGDITTEDE 255
Query: 244 AASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASGNG 303
AASLIYGLDVNDIYSCSWGP+DDG+ +Q P LVKKA++KGVTEGRD+KGA+YVFASGNG
Sbjct: 256 AASLIYGLDVNDIYSCSWGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFASGNG 315
Query: 304 GMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGNYIKTTDLDE 363
G GD+CN+DGYTNSI+SIT+GAID K LHPPYSE CSAVM VTYSSGSG YI ++D++
Sbjct: 316 GTRGDNCNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSSGSGEYIHSSDING 375
Query: 364 KCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPH-DGKWQDTAMG 422
+CSN+HGGTSAAAPLAAG+YTL+LEANPNLTWRDVQYLSILS+ + + DG W+D+AMG
Sbjct: 376 RCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSAVGLEKNADGDWRDSAMG 435
Query: 423 KRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVIESTVSVSAE 482
K+YSH YGFGK+DA+ ++ M+K+W NVN Q W YLPT+ QS ++++E +ES +++S +
Sbjct: 436 KKYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYLPTLYVSQSTNSTEETLESVITISEK 495
Query: 483 EFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNRYGFQNWTFM 542
+ N KR+EHVTVTVDID RG VDLISP G+ S L R D + GF++WTFM
Sbjct: 496 SLQDANFKRIEHVTVTVDIDTEIRGTTTVDLISPAGIISNLGVVRPRDVSSEGFKDWTFM 555
Query: 543 SVAHWGSSGVGSWKLKVKSTHDNEIVTLKSWRLKMFGETIDAKKAKVISYGNDKEDAEVK 602
SVAHWG +GVG WK+KVK+T + + SWRLK+FGE+ID+ K + +GNDKE+ E
Sbjct: 556 SVAHWGENGVGDWKIKVKTTENGHRIDFHSWRLKLFGESIDSSKTETFVFGNDKEEVEPA 615
Query: 603 XXXXXXXXXXXXXXXXXXXXXXXXXXA-------------------------NKLPRPEQ 637
+ KL P Q
Sbjct: 616 ATESTVSQYSASSTSISISATSTSSISIGVETSAIPQTTTASTDPDSDPNTPKKLSSPRQ 675
Query: 638 AAQLYXXXXXXXXXXXXXXXXXFLKXXXXXXXXXAEAYEFDIIDTDSEYDSSINQTAESI 697
A + F+K AE YEFDIIDTDSEYDS+++
Sbjct: 676 AMHYFLTIFLIGATFLVLYFMFFMKSRRRIRRSRAETYEFDIIDTDSEYDSTLD---NGT 732
Query: 698 SGEVNDDNLEDFNFDINEEELSPRESSSNNPFGNESLES 736
SG + +EDF+FD+++E+ SSS N +++S
Sbjct: 733 SGITEPEEVEDFDFDLSDEDHLASLSSSENGDAEHTIDS 771
>SPAC22E12.09c [O] KOG3525 Subtilisin-like proprotein convertase
Length = 709
Score = 456 bits (1174), Expect = e-128
Identities = 241/529 (45%), Positives = 330/529 (61%), Gaps = 13/529 (2%)
Query: 71 LQSLGKRDAIDTGYSENIIDFHDLPPVQLHKRLPIGDSSMEQIQNARILFNISDPLFDQQ 130
+QS ++ ID G I++ P +KR S E + F ISDPLF Q
Sbjct: 75 VQSSIRKRGIDAG----ILELERQTPRWRYKR--DASESDELLNEFSNHFGISDPLFYGQ 128
Query: 131 WHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGSWDFNDNN 190
WH+ N N PG+D+N+ +W G V A VDDG+D+++ DL+ + GSWDFNDN
Sbjct: 129 WHIFNSNNPGHDLNLREVWDAGYFGENVTVAFVDDGIDFKHPDLQAAYTSLGSWDFNDNI 188
Query: 191 PLPKPRLKDDYHGTRCAGEIAAFRNDICGVGVAYNSKVSGIRILSGQITAEDEAASLIYG 250
P P+L DD HGTRCAGE+AA ND+CGVG+A +KV+G+RILS IT E+ +L YG
Sbjct: 189 ADPLPKLSDDQHGTRCAGEVAAAWNDVCGVGIAPRAKVAGLRILSAPITDAVESEALNYG 248
Query: 251 LDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASGNGGMFGDSC 310
N IYSCSWGP+DDG+ M AP+T ++A++ GV GR+ G+++VFASGNGG + D+C
Sbjct: 249 FQTNHIYSCSWGPADDGRAMDAPNTATRRALMNGVLNGRNGLGSIFVFASGNGGHYHDNC 308
Query: 311 NFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGNYIKTTDLDEKCSNTHG 370
NFDGYTNSIFS T+GA+D + P YSE C+A +V YSSGS I TT+ + C+ +HG
Sbjct: 309 NFDGYTNSIFSATIGAVDAEHKIPFYSEVCAAQLVSAYSSGSHLSILTTNPEGTCTRSHG 368
Query: 371 GTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEIN--PHDGKWQDTAMGKRYSHT 428
GTSAAAPLA+ +Y L L P+L+WRD+Q++++ S+ + + +WQ T G ++SH
Sbjct: 369 GTSAAAPLASAVYALALSIRPDLSWRDIQHITVYSASPFDSPSQNAEWQKTPAGFQFSHH 428
Query: 429 YGFGKLDAYNIVHMAKSWINVNPQGWLYLPTI-VEKQSISNSDEVIESTVS---VSAEEF 484
+GFGKLDA V +AK W VNPQ WL P I V K S ++E I VS V+ +
Sbjct: 429 FGFGKLDASKFVEVAKDWQVVNPQTWLIAPEINVNKSFGSVNNETITEMVSEFTVTKDMI 488
Query: 485 KQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNRYGFQNWTFMSV 544
+++N KRLEHVTV V I RG + + L SP G+ S LA+ R D+N GF +WTFM+V
Sbjct: 489 EKSNFKRLEHVTVRVCIPFNRRGALEILLESPSGIRSILASERPYDENSKGFLDWTFMTV 548
Query: 545 AHWGSSGVGSWKLKVKSTHDNEIV-TLKSWRLKMFGETIDAKKAKVISY 592
HW G WKL V + T ++W+L ++GE+ + + Y
Sbjct: 549 QHWAEPPEGVWKLLVNDRSGGKHEGTFENWQLALWGESENPSNTAPLPY 597
>Hs20336248 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 785
Score = 404 bits (1039), Expect = e-112
Identities = 214/540 (39%), Positives = 314/540 (57%), Gaps = 28/540 (5%)
Query: 61 LANHYVFSKPLQSLGKRDAIDTG----YSENIIDFHDLPPVQLHKRLPIGDSSMEQIQNA 116
L HY+F +P G R A++ E ++ H+ V+ H S ++ A
Sbjct: 92 LQGHYLFVQPA---GHRPALEVEAIRQQVEAVLAGHEA--VRWH-------SEQRLLRRA 139
Query: 117 RILFNISDPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKD 176
+ + +DP + QQWHL N PG D+NVTG+W+ N+TG GV +VDDG+++ +D+
Sbjct: 140 KRSVHFNDPKYPQQWHLNNRRSPGRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAP 199
Query: 177 NFCVEGSWDFNDNNPLPKPRL---KDDYHGTRCAGEIAAF-RNDICGVGVAYNSKVSGIR 232
N+ EGS+D N N+P P P ++HGTRCAGEIAA N C VGVAY S+++GIR
Sbjct: 200 NYSPEGSYDLNSNDPDPMPHPDVENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIR 259
Query: 233 ILSGQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAK 292
+L G +T EA + +NDIYSCSWGP DDGKT+ P L K A+ GV GR
Sbjct: 260 VLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVIAGRQGF 319
Query: 293 GALYVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS 352
G+++V ASGNGG D+CN+DGY NSI+++T+GA+D +G P Y+E C++++ VT+S G
Sbjct: 320 GSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGD 379
Query: 353 G--NYIKTTDLDEK----CSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSS 406
I TTD D + C+ H GTSAAAPLAAG+ L+L+ P LTWRDVQ++ + ++
Sbjct: 380 KMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTA 439
Query: 407 EEINPHDGKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSI 466
+W G +SH +GFG L+A+ +V+ AK W +V P + E ++I
Sbjct: 440 TRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPVLKENKAI 499
Query: 467 SNSDEVIESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATA 526
S +E +VS + + + LK LEHV VTV I P RG + + L P G+ S +
Sbjct: 500 PQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAP 559
Query: 527 RRLDKNRYGFQNWTFMSVAHWGSSGVGSWKLKVKSTHDN--EIVTLKSWRLKMFGETIDA 584
R +D + GF +WTF +V WG G+++L ++ D ++ L+ W+L ++G A
Sbjct: 560 RSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSA 619
>Hs4505579 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 794
Score = 379 bits (972), Expect = e-104
Identities = 198/466 (42%), Positives = 291/466 (61%), Gaps = 16/466 (3%)
Query: 123 SDPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEG 182
+DP F QQW+L D+NV W + TG+G+V +++DDG++ + DL N+
Sbjct: 114 TDPKFPQQWYLSGVTQ--RDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGA 171
Query: 183 SWDFNDNNPLPKPR---LKDDYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILSGQI 238
S+D ND +P P+PR + D+ HGTRCAGE+AA N+ +CGVGVAYN+++ G+R+L G++
Sbjct: 172 SFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEV 231
Query: 239 TAEDEAASLIYGLDVNDI--YSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALY 296
T EA SL GL+ N I YS SWGP DDGKT+ P L ++A +GV++GR G+++
Sbjct: 232 TDAVEARSL--GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIF 289
Query: 297 VFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGN-- 354
V+ASGNGG DSCN DGYTNSI+++++ + G P YSE+CS+ + TYSSG+ N
Sbjct: 290 VWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEK 349
Query: 355 YIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHDG 414
I TTDL +KC+ +H GTSA+APLAAGI L LEAN NLTWRD+Q+L + +S+ + +
Sbjct: 350 QIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAN 409
Query: 415 KWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVIE 474
W +G++ SH+YG+G LDA +V +A++W V PQ + + E + I EV +
Sbjct: 410 DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRK 469
Query: 475 STVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNRY 534
+ + E N++ RLEH + + RG + + L+SP G STL AR D +
Sbjct: 470 TVTACLGE---PNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSAD 526
Query: 535 GFQNWTFMSVAHWGSSGVGSWKLKVKSTHD-NEIVTLKSWRLKMFG 579
GF +W FM+ W G W L++++T + N TL + L ++G
Sbjct: 527 GFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYG 572
>CE17653 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 692
Score = 365 bits (937), Expect = e-100
Identities = 198/471 (42%), Positives = 278/471 (58%), Gaps = 17/471 (3%)
Query: 123 SDPLFDQQWHLINPNYPGN-----DVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDN 177
+DPL+ W+L + + D NV W TG GVV ++DDGL+ + D+ N
Sbjct: 175 NDPLWTDMWYLNRGEHHSDSTTRMDHNVKEAWDLGYTGKGVVVTILDDGLERTHPDISPN 234
Query: 178 FCVEGSWDFND--NNPLPKPRLKDDY-HGTRCAGEIAA-FRNDICGVGVAYNSKVSGIRI 233
+ S+D ND N+P+P+ D+ HGTRCAGE+AA F N +C VG+AYN+ + GIR+
Sbjct: 235 YDERASYDVNDRDNDPMPRYEFSDENRHGTRCAGEVAAIFNNSLCIVGIAYNANIGGIRM 294
Query: 234 LSGQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKG 293
L G +T EAAS+ + D DIYS SWGP DDG+T+ P L + A KG+T GR KG
Sbjct: 295 LDGDVTDAVEAASVGHNADYIDIYSASWGPDDDGRTVDGPAKLTRSAFEKGITMGRKGKG 354
Query: 294 ALYVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS- 352
+++V+ASGNGG DSCN DGYTNSI+++++ + G P YSE+CS+ + TYSSG+
Sbjct: 355 SIFVWASGNGGKDADSCNCDGYTNSIYTLSISSATENGNIPWYSEACSSTLATTYSSGAT 414
Query: 353 -GNYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINP 411
I TTDL C+N H GTSA+APLAAGI L LEANPNLTWRD+Q++ I +++ IN
Sbjct: 415 GEKMILTTDLHHACTNMHTGTSASAPLAAGIVALALEANPNLTWRDLQHIVIRTAKPINL 474
Query: 412 HDGKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDE 471
G W +G+ SH++G+G +DA +V +AK W V+ Q ++I N +
Sbjct: 475 RAGDWTTNGVGRNVSHSFGYGLMDAGAMVKLAKIWKKVDEQHRCRQFYPSRYKNIPNGNR 534
Query: 472 VIESTVSVSA-EEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLD 530
+ S +N + +EHV V + AP RG + + L SP G STL T R D
Sbjct: 535 LQLQLYSDGCYGGADENKVSYVEHVQAIVTLKAPKRGDLQIYLTSPSGTKSTLLTKRARD 594
Query: 531 KNRYGFQNWTFMSVAHWGSSGVGSWKLKVKST--HDNEIVTLKSWRLKMFG 579
+R GF +W FM+ +WG G W L++ + D E+V W L ++G
Sbjct: 595 TSRSGFTDWAFMTTHNWGEQAAGLWILEIDNDGWDDAELV---KWELVLYG 642
>Hs20336242 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 753
Score = 360 bits (925), Expect = 3e-99
Identities = 222/594 (37%), Positives = 335/594 (56%), Gaps = 49/594 (8%)
Query: 25 KKDHENRQYFAIESYDDVGNLLAEHSDWSFEHDVRGLANHYVF---SKPLQSLGKRDAID 81
K+ N I + + +AE + + L NHY+F + P +S I
Sbjct: 28 KRQFVNEWAAEIPGGPEAASAIAEELGYDLLGQIGSLENHYLFKHKNHPRRSRRSAFHIT 87
Query: 82 TGYSEN--IIDFHDLPPVQLHKRLPIGDSSMEQIQNARILFNISDPLFDQQWHL----IN 135
S++ +I + KR + DS++ LFN DP+++QQW+L +
Sbjct: 88 KRLSDDDRVIWAEQQYEKERSKRSALRDSALN-------LFN--DPMWNQQWYLQDTRMT 138
Query: 136 PNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGSWDFNDNNPLPKP 195
P D++V +W++ ITG GVV ++DDGL++ + D+ N+ E S+DFNDN+ P P
Sbjct: 139 AALPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFP 198
Query: 196 RL---KDDYHGTRCAGEIAAFRNDI-CGVGVAYNSKVSGIRILSGQITAEDEAASLIYGL 251
R ++ HGTRCAGEIA N+ CGVGVAYNSKV GIR+L G +T EA+S+ +
Sbjct: 199 RYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNP 258
Query: 252 DVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASGNGGMFGDSCN 311
DIYS SWGP+DDGKT++ P L +KA GV +GR KG+++V+ASGNGG GD+C+
Sbjct: 259 GHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCD 318
Query: 312 FDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSG--SGNYIKTTDLDEKCSNTH 369
DGYT+SI++I++ + +GL P Y+E CS+ + +YSSG + I + DL C+ TH
Sbjct: 319 CDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETH 378
Query: 370 GGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSE-EINPHDGKWQDTAMGKRYSHT 428
GTSA+APLAAGI+ L LEANPNLTWRD+Q+L + +SE + ++ W+ G +
Sbjct: 379 TGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSR 438
Query: 429 YGFGKLDAYNIVHMAKSWINVNPQGWLYLP---------TIVEKQSISNSDEVIESTVSV 479
+GFG L+A +V +A +P+ W +P E +++ + EVI +
Sbjct: 439 FGFGLLNAKALVDLA------DPRTWRSVPEKKECVVKDNDFEPRALKANGEVI-IEIPT 491
Query: 480 SAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNRYGFQNW 539
A E ++N +K LEHV I+ RG + V L S G ++ L R D + GF+NW
Sbjct: 492 RACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNW 551
Query: 540 TFMSVAHWGSSGVGSWKLKV-----KSTHDNEIVTLKSWRLKMFGETIDAKKAK 588
FMSV WG + +G+W L++ + ++ IV +W+L + G + + K
Sbjct: 552 DFMSVHTWGENPIGTWTLRITDMSGRIQNEGRIV---NWKLILHGTSSQPEHMK 602
>Hs20336244 [O] KOG3526 Subtilisin-like proprotein convertase
Length = 638
Score = 357 bits (916), Expect = 4e-98
Identities = 198/478 (41%), Positives = 292/478 (60%), Gaps = 23/478 (4%)
Query: 121 NISDPLFDQQWHLINPNY----PGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKD 176
N++DPLF +QW+LIN PG D+NV W+ TG GV ++DDG+DY + DL
Sbjct: 120 NMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLAS 179
Query: 177 NFCVEGSWDFNDNNPLPKPRLKDDY---HGTRCAGEI-AAFRNDICGVGVAYNSKVSGIR 232
N+ E S+DF+ N+P P PR DD+ HGTRCAGE+ AA N+ICGVGVAYNSKV+GIR
Sbjct: 180 NYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIR 239
Query: 233 ILSGQITAED-EAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDA 291
+L + EA+S+ + + DIYS SWGP+D+GKT+ P L +A+ GV +GR
Sbjct: 240 MLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGG 299
Query: 292 KGALYVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSG 351
KG++YV+ASG+GG + D CN DGY +S+++I++ + G Y ESCS+ + T+S+G
Sbjct: 300 KGSIYVWASGDGGSY-DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNG 358
Query: 352 SGNY----IKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSE 407
+ TTDL C+ H GTSAAAP AAG++ L LEAN LTWRD+Q+L++L+S+
Sbjct: 359 RKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSK 418
Query: 408 EINPHD--GKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQS 465
HD +W+ +G ++H +G+G LDA +V MAK W V + ++ + +
Sbjct: 419 RNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEK 478
Query: 466 ISNSDEVIESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLAT 525
I ++ +++ T++ A E K+N ++ LEHV + ++A RG + +++ SP G S L +
Sbjct: 479 IPSTGKLV-LTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLS 537
Query: 526 AR-RLDKNRYGFQNWTFMSVAHWGSSGVGSWKLK---VKSTHDNEIVTLKSWRLKMFG 579
R R D ++ GF W FM+ WG G+W L+ V S + LK W L + G
Sbjct: 538 RRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGV--LKEWTLMLHG 593
>7293216 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 1679
Score = 348 bits (892), Expect = 2e-95
Identities = 198/492 (40%), Positives = 279/492 (56%), Gaps = 30/492 (6%)
Query: 120 FNISDPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFC 179
F DPLF +QW+L G D+NV W++ TG GVV +++DDG+ + DL N+
Sbjct: 373 FIFPDPLFKEQWYLNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYD 432
Query: 180 VEGSWDFNDNNPLPKPRLK-DDYHGTRCAGEIAAFR-NDICGVGVAYNSKVSGIRILSGQ 237
E S+D N N+ P P+ D+ HGTRCAGE+AA N+ CGVGVAYN+ + G+R+L G+
Sbjct: 433 PEASFDINGNDSDPTPQDNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 492
Query: 238 ITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYV 297
+ EA +L DIYS SWGP DDG T+ P L ++A I GVT GR KG+++V
Sbjct: 493 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFV 552
Query: 298 FASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGNY-- 355
+ASGNGG + DSCN DGYTNSIF++++ + G P Y E CS+ + TYSSG+ +
Sbjct: 553 WASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDK 612
Query: 356 -IKTTDLDEK------CSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEE 408
+ T D+D C+ H GTSA+APLAAGI L LEANP LTWRD+QYL + +S
Sbjct: 613 SVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRP 672
Query: 409 IN-PHDGKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSIS 467
+ W + ++YSH +G+G +DA +V +A+ W +V PQ + K +
Sbjct: 673 APLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQH-------ICKSREN 725
Query: 468 NSDEVIE----STVS----VSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGV 519
N D I+ ST+S V+ N ++ LEHV + + RG++ + L SP G
Sbjct: 726 NEDRKIDGAYGSTLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGT 785
Query: 520 TSTLATARRLDKNRYGFQNWTFMSVAHWGSSGVGSWKLKVKS---THDNEIVTLKSWRLK 576
TSTL R D + F +W F+SV WG G W L+V + N+ L W+L
Sbjct: 786 TSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLI 845
Query: 577 MFGETIDAKKAK 588
+G + + K
Sbjct: 846 FYGTSTQPMRLK 857
>7301334 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 901
Score = 347 bits (890), Expect = 4e-95
Identities = 191/499 (38%), Positives = 290/499 (57%), Gaps = 27/499 (5%)
Query: 121 NISDPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCV 180
+ +D + Q W+L G D+NV WK ITG GVV ++DDGL+ ++ D++DN+
Sbjct: 333 SFNDSKWPQMWYLNRGG--GLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDP 390
Query: 181 EGSWDFN--DNNPLPKPRLKD-DYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILSG 236
+ S+D N D++P+P + D + HGTRCAGE+AA N+ C VG+AY + V G+R+L G
Sbjct: 391 KASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDG 450
Query: 237 QITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALY 296
+T EA SL DIYS SWGP DDGKT+ P L +A I+G T+GR KG+++
Sbjct: 451 DVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIF 510
Query: 297 VFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSG--SGN 354
++ASGNGG D+CN DGYTNSI+++++ + +G P YSE CS+ + TYSSG
Sbjct: 511 IWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEK 570
Query: 355 YIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHDG 414
+ TTDL C+ +H GTSA+APLAAGI LVL++N NLTWRD+Q++ + +++ N D
Sbjct: 571 QVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDP 630
Query: 415 KWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVIE 474
W +G+R SH++G+G +DA +V +A++W V Q + + + D+VI
Sbjct: 631 SWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEI-------NAPHVDKVIP 683
Query: 475 STVSVSAEEFKQN--NLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKN 532
++ + + ++ LEHV + + + RG + + L SP + TL T R D +
Sbjct: 684 PRTHITLQLTVNHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNS 743
Query: 533 RYGFQNWTFMSVAHWGSSGVGSWKLKVKSTHDNEIVTLKSWRLKMFGETIDAKKAKVIS- 591
R GF W FMSV WG S G+W+L++ + + + W + +G A+ V +
Sbjct: 744 RSGFNQWPFMSVHTWGESPQGNWQLEIHN-EGRYMAQITQWDMIFYGTETPAQPDDVANP 802
Query: 592 --------YGNDKEDAEVK 602
YGND +V+
Sbjct: 803 SQSNQFNLYGNDMAHNDVE 821
>7301335 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 1269
Score = 345 bits (885), Expect = 1e-94
Identities = 187/470 (39%), Positives = 280/470 (58%), Gaps = 18/470 (3%)
Query: 121 NISDPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCV 180
+ +D + Q W+L G D+NV WK ITG GVV ++DDGL+ ++ D++DN+
Sbjct: 331 SFNDSKWPQMWYLNRGG--GLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDP 388
Query: 181 EGSWDFN--DNNPLPKPRLKD-DYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILSG 236
+ S+D N D++P+P + D + HGTRCAGE+AA N+ C VG+AY + V G+R+L G
Sbjct: 389 KASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDG 448
Query: 237 QITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALY 296
+T EA SL DIYS SWGP DDGKT+ P L +A I+G T+GR KG+++
Sbjct: 449 DVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIF 508
Query: 297 VFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSG--SGN 354
++ASGNGG D+CN DGYTNSI+++++ + +G P YSE CS+ + TYSSG
Sbjct: 509 IWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEK 568
Query: 355 YIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHDG 414
+ TTDL C+ +H GTSA+APLAAGI LVL++N NLTWRD+Q++ + +++ N D
Sbjct: 569 QVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDP 628
Query: 415 KWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVIE 474
W +G+R SH++G+G +DA +V +A++W V Q + + + D+VI
Sbjct: 629 SWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEI-------NAPHVDKVIP 681
Query: 475 STVSVSAEEFKQN--NLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKN 532
++ + + ++ LEHV + + + RG + + L SP + TL T R D +
Sbjct: 682 PRTHITLQLTVNHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNS 741
Query: 533 RYGFQNWTFMSVAHWGSSGVGSWKLKVKST-HDNEIVTLKSWRLKMFGET 581
R GF W FMSV WG S G+W+L++ + L+ W L +G T
Sbjct: 742 RSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTT 791
>7301492 [O] KOG3526 Subtilisin-like proprotein convertase
Length = 654
Score = 342 bits (876), Expect = 2e-93
Identities = 194/475 (40%), Positives = 277/475 (57%), Gaps = 20/475 (4%)
Query: 123 SDPLFDQQWHLINPNYPGN----DVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNF 178
+DP F QW+L N G D+NV W + ITG V A++DDG+DY + DLK N+
Sbjct: 151 TDPYFPMQWYLKNTGQNGGKVRLDLNVQAAWAQGITGKNVTTAIMDDGVDYMHPDLKFNY 210
Query: 179 CVEGSWDFNDNNPLPKPRLKDDY---HGTRCAGEIAAFR-NDICGVGVAYNSKVSGIRIL 234
E S+DF+ N+P P PR DD+ HGTRCAGE+AA R N ICGVGVAY+SK++GIR+L
Sbjct: 211 NAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEVAAARDNGICGVGVAYDSKIAGIRML 270
Query: 235 SGQ-ITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKG 293
+T EA S+ + IYS SWGP+DDGKT+ P +AI++GV EGR+ G
Sbjct: 271 DQPYMTDLIEANSMGHEPHKIHIYSASWGPTDDGKTVDGPRNATMRAIVQGVNEGRNGLG 330
Query: 294 ALYVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS- 352
+YV+ASG+GG D CN DGY S+++I++ + G + Y ESCS+ + T+S+G+
Sbjct: 331 NIYVWASGDGGE-EDDCNCDGYAASMWTISINSAINDGQNAHYDESCSSTLASTFSNGAK 389
Query: 353 --GNYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEIN 410
+ TTDL KC+ TH GTSAAAP AAG++ L LEANP LTWRD+Q+L++L+S+ +
Sbjct: 390 DPNTGVATTDLYGKCTTTHSGTSAAAPEAAGVFALALEANPQLTWRDIQHLTVLTSKRNS 449
Query: 411 PHDGK----WQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSI 466
D K W +G ++H +GFG LDA +V ++K W +V P+ + + Q+I
Sbjct: 450 LFDAKNRFHWTMNGVGLEFNHLFGFGVLDAGAMVTLSKQWHSVPPRYHCEAGELTQPQAI 509
Query: 467 SNSDEVIESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATA 526
+ + A + + LEHV + +A RG + + L SP G S + +
Sbjct: 510 VMGRSLFWE-IKTDACKGTDTEVNYLEHVQAVISANASRRGDLELFLTSPMGTKSMILSR 568
Query: 527 R-RLDKNRYGFQNWTFMSVAHWGSSGVGSWKLKVK-STHDNEIVTLKSWRLKMFG 579
R D +R GF W FM+ WG G+WKL+ + ++ L W L + G
Sbjct: 569 RANDDDHRDGFTKWPFMTTHSWGEYPQGTWKLEARFNSPQTRHGNLLEWSLVLHG 623
>Hs4505577 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 969
Score = 338 bits (866), Expect = 2e-92
Identities = 186/471 (39%), Positives = 263/471 (55%), Gaps = 14/471 (2%)
Query: 123 SDPLFDQQWHLINPNYPG---NDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFC 179
+DP++ W+L + +++NV WK TG VV ++DDG++ + DL N+
Sbjct: 161 NDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYD 220
Query: 180 VEGSWDFNDNNPLPKPRL---KDDYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILS 235
S+D N N+ P PR ++ HGTRCAGE+AA N+ C VG+AYN+K+ GIR+L
Sbjct: 221 SYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLD 280
Query: 236 GQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGAL 295
G +T EA SL + DIYS SWGP DDGKT+ P L K+A G+ +GR G++
Sbjct: 281 GDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSI 340
Query: 296 YVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS--G 353
+V+ASGNGG GD C+ DGYTNSI++I+V + G P Y E C++ + TYSSG+
Sbjct: 341 FVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYE 400
Query: 354 NYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHD 413
I TTDL ++C++ H GTS +AP+ AGI L LEAN LTWRDVQ+L + +S +
Sbjct: 401 RKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKA 460
Query: 414 GKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI 473
W+ G + SH YGFG +DA +V AK W V Q + +SI +
Sbjct: 461 SDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLR 520
Query: 474 ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNR 533
+ ++ + E + LEHV V I P RG + + L+SP G S L R LD +
Sbjct: 521 TTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSN 580
Query: 534 YGFQNWTFMSVAHWGSSGVGSWKLKVKS-----THDNEIVTLKSWRLKMFG 579
GF NW FM+V WG G W L+++ + + LK W L ++G
Sbjct: 581 EGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYG 631
>Hs20336184 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 962
Score = 338 bits (866), Expect = 2e-92
Identities = 186/471 (39%), Positives = 263/471 (55%), Gaps = 14/471 (2%)
Query: 123 SDPLFDQQWHLINPNYPG---NDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFC 179
+DP++ W+L + +++NV WK TG VV ++DDG++ + DL N+
Sbjct: 161 NDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYD 220
Query: 180 VEGSWDFNDNNPLPKPRL---KDDYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILS 235
S+D N N+ P PR ++ HGTRCAGE+AA N+ C VG+AYN+K+ GIR+L
Sbjct: 221 SYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLD 280
Query: 236 GQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGAL 295
G +T EA SL + DIYS SWGP DDGKT+ P L K+A G+ +GR G++
Sbjct: 281 GDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSI 340
Query: 296 YVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS--G 353
+V+ASGNGG GD C+ DGYTNSI++I+V + G P Y E C++ + TYSSG+
Sbjct: 341 FVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYE 400
Query: 354 NYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHD 413
I TTDL ++C++ H GTS +AP+ AGI L LEAN LTWRDVQ+L + +S +
Sbjct: 401 RKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKA 460
Query: 414 GKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI 473
W+ G + SH YGFG +DA +V AK W V Q + +SI +
Sbjct: 461 SDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLR 520
Query: 474 ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNR 533
+ ++ + E + LEHV V I P RG + + L+SP G S L R LD +
Sbjct: 521 TTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSN 580
Query: 534 YGFQNWTFMSVAHWGSSGVGSWKLKVKS-----THDNEIVTLKSWRLKMFG 579
GF NW FM+V WG G W L+++ + + LK W L ++G
Sbjct: 581 EGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYG 631
>Hs20336182 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 975
Score = 338 bits (866), Expect = 2e-92
Identities = 186/471 (39%), Positives = 263/471 (55%), Gaps = 14/471 (2%)
Query: 123 SDPLFDQQWHLINPNYPG---NDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFC 179
+DP++ W+L + +++NV WK TG VV ++DDG++ + DL N+
Sbjct: 161 NDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYD 220
Query: 180 VEGSWDFNDNNPLPKPRL---KDDYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILS 235
S+D N N+ P PR ++ HGTRCAGE+AA N+ C VG+AYN+K+ GIR+L
Sbjct: 221 SYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLD 280
Query: 236 GQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGAL 295
G +T EA SL + DIYS SWGP DDGKT+ P L K+A G+ +GR G++
Sbjct: 281 GDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSI 340
Query: 296 YVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS--G 353
+V+ASGNGG GD C+ DGYTNSI++I+V + G P Y E C++ + TYSSG+
Sbjct: 341 FVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYE 400
Query: 354 NYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHD 413
I TTDL ++C++ H GTS +AP+ AGI L LEAN LTWRDVQ+L + +S +
Sbjct: 401 RKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKA 460
Query: 414 GKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI 473
W+ G + SH YGFG +DA +V AK W V Q + +SI +
Sbjct: 461 SDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLR 520
Query: 474 ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNR 533
+ ++ + E + LEHV V I P RG + + L+SP G S L R LD +
Sbjct: 521 TTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSN 580
Query: 534 YGFQNWTFMSVAHWGSSGVGSWKLKVKS-----THDNEIVTLKSWRLKMFG 579
GF NW FM+V WG G W L+++ + + LK W L ++G
Sbjct: 581 EGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYG 631
>Hs20336180 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 956
Score = 338 bits (866), Expect = 2e-92
Identities = 186/471 (39%), Positives = 263/471 (55%), Gaps = 14/471 (2%)
Query: 123 SDPLFDQQWHLINPNYPG---NDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFC 179
+DP++ W+L + +++NV WK TG VV ++DDG++ + DL N+
Sbjct: 161 NDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYD 220
Query: 180 VEGSWDFNDNNPLPKPRL---KDDYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILS 235
S+D N N+ P PR ++ HGTRCAGE+AA N+ C VG+AYN+K+ GIR+L
Sbjct: 221 SYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLD 280
Query: 236 GQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGAL 295
G +T EA SL + DIYS SWGP DDGKT+ P L K+A G+ +GR G++
Sbjct: 281 GDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSI 340
Query: 296 YVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS--G 353
+V+ASGNGG GD C+ DGYTNSI++I+V + G P Y E C++ + TYSSG+
Sbjct: 341 FVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYE 400
Query: 354 NYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHD 413
I TTDL ++C++ H GTS +AP+ AGI L LEAN LTWRDVQ+L + +S +
Sbjct: 401 RKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKA 460
Query: 414 GKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI 473
W+ G + SH YGFG +DA +V AK W V Q + +SI +
Sbjct: 461 SDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLR 520
Query: 474 ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNR 533
+ ++ + E + LEHV V I P RG + + L+SP G S L R LD +
Sbjct: 521 TTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSN 580
Query: 534 YGFQNWTFMSVAHWGSSGVGSWKLKVKS-----THDNEIVTLKSWRLKMFG 579
GF NW FM+V WG G W L+++ + + LK W L ++G
Sbjct: 581 EGFTNWEFMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYG 631
>Hs20336190 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 652
Score = 335 bits (858), Expect = 2e-91
Identities = 181/447 (40%), Positives = 254/447 (56%), Gaps = 9/447 (2%)
Query: 123 SDPLFDQQWHLINPNYPG---NDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFC 179
+DP++ W+L + +++NV WK TG VV ++DDG++ + DL N+
Sbjct: 161 NDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYD 220
Query: 180 VEGSWDFNDNNPLPKPRL---KDDYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILS 235
S+D N N+ P PR ++ HGTRCAGE+AA N+ C VG+AYN+K+ GIR+L
Sbjct: 221 SYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLD 280
Query: 236 GQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGAL 295
G +T EA SL + DIYS SWGP DDGKT+ P L K+A G+ +GR G++
Sbjct: 281 GDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSI 340
Query: 296 YVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS--G 353
+V+ASGNGG GD C+ DGYTNSI++I+V + G P Y E C++ + TYSSG+
Sbjct: 341 FVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYE 400
Query: 354 NYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHD 413
I TTDL ++C++ H GTS +AP+ AGI L LEAN LTWRDVQ+L + +S +
Sbjct: 401 RKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKA 460
Query: 414 GKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI 473
W+ G + SH YGFG +DA +V AK W V Q + +SI +
Sbjct: 461 SDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLR 520
Query: 474 ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNR 533
+ ++ + E + LEHV V I P RG + + L+SP G S L R LD +
Sbjct: 521 TTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSN 580
Query: 534 YGFQNWTFMSVAHWGSSGVGSWKLKVK 560
GF NW FM+V WG G W L+++
Sbjct: 581 EGFTNWEFMTVHCWGEKAEGQWTLEIQ 607
>Hs20336188 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 623
Score = 335 bits (858), Expect = 2e-91
Identities = 181/447 (40%), Positives = 254/447 (56%), Gaps = 9/447 (2%)
Query: 123 SDPLFDQQWHLINPNYPG---NDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFC 179
+DP++ W+L + +++NV WK TG VV ++DDG++ + DL N+
Sbjct: 161 NDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYD 220
Query: 180 VEGSWDFNDNNPLPKPRL---KDDYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILS 235
S+D N N+ P PR ++ HGTRCAGE+AA N+ C VG+AYN+K+ GIR+L
Sbjct: 221 SYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLD 280
Query: 236 GQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGAL 295
G +T EA SL + DIYS SWGP DDGKT+ P L K+A G+ +GR G++
Sbjct: 281 GDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSI 340
Query: 296 YVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS--G 353
+V+ASGNGG GD C+ DGYTNSI++I+V + G P Y E C++ + TYSSG+
Sbjct: 341 FVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYE 400
Query: 354 NYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHD 413
I TTDL ++C++ H GTS +AP+ AGI L LEAN LTWRDVQ+L + +S +
Sbjct: 401 RKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKA 460
Query: 414 GKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI 473
W+ G + SH YGFG +DA +V AK W V Q + +SI +
Sbjct: 461 SDWKVNGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLR 520
Query: 474 ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNR 533
+ ++ + E + LEHV V I P RG + + L+SP G S L R LD +
Sbjct: 521 TTALTSACAEHSDQRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSN 580
Query: 534 YGFQNWTFMSVAHWGSSGVGSWKLKVK 560
GF NW FM+V WG G W L+++
Sbjct: 581 EGFTNWEFMTVHCWGEKAEGQWTLEIQ 607
>CE08940 [O] KOG3526 Subtilisin-like proprotein convertase
Length = 652
Score = 333 bits (855), Expect = 4e-91
Identities = 193/496 (38%), Positives = 280/496 (55%), Gaps = 42/496 (8%)
Query: 123 SDPLFDQQWHLINPNYPGN----DVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNF 178
SDPL+ QW+L N G D+NV W TG + A++DDG+DY + D+K+NF
Sbjct: 129 SDPLYGYQWYLKNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNF 188
Query: 179 CVEGSWDFNDNNPLPKPRLKDDY---HGTRCAGEIAAFR-NDICGVGVAYNSKVSGIRIL 234
E S+DF+ N+P P PR DD+ HGTRCAGEI A R N +CGVGVAY+ KV+GIR+L
Sbjct: 189 NAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRML 248
Query: 235 SGQ-ITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKG 293
+T EA S+ + IYS SWGP+DDGKT+ P +AI++GV EGR+ G
Sbjct: 249 DQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLG 308
Query: 294 ALYVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSG 353
+++V+ASG+GG D CN DGY S+++I++ + G + Y ESCS+ + T+S+G
Sbjct: 309 SIFVWASGDGGE-DDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGR 367
Query: 354 NY---IKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEIN 410
N + TTDL +C+ +H GTSAAAP AAG++ L LEANP+LTWRD+Q+L++L+S +
Sbjct: 368 NPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNS 427
Query: 411 PHDGK------------------------WQDTAMGKRYSHTYGFGKLDAYNIVHMAKSW 446
DG+ WQ +G Y+H +GFG LDA +V +A +W
Sbjct: 428 LFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAW 487
Query: 447 INVNPQGWLYLPTIVEKQSISNSDEVIESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYR 506
+P + +++ +D + ++ Q ++ LEHV V ++ R
Sbjct: 488 -KTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRR 546
Query: 507 GHVLVDLISPDGVTSTLATARRL--DKNRYGFQNWTFMSVAHWGSSGVGSWKLKVKSTHD 564
G + LISP G T T+ +RR D ++ GF NW FM+ WG + G W+L +
Sbjct: 547 GDTTLYLISPMG-TRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARFQGP 605
Query: 565 N-EIVTLKSWRLKMFG 579
TLK + L + G
Sbjct: 606 GAHAGTLKKFELMLHG 621
>Hs20336246 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 913
Score = 333 bits (854), Expect = 6e-91
Identities = 184/474 (38%), Positives = 265/474 (55%), Gaps = 14/474 (2%)
Query: 123 SDPLFDQQW--HLINPNYP-GNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFC 179
+DP + W H + +P +D+N+ G WK TG +V ++DDG++ + DL N+
Sbjct: 127 NDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYD 186
Query: 180 VEGSWDFNDNNPLPKPRL---KDDYHGTRCAGEIAAFRNDI-CGVGVAYNSKVSGIRILS 235
S D N N+ P PR ++ HGTRCAGE+AA N+ C VG+A+N+K+ G+R+L
Sbjct: 187 ALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLD 246
Query: 236 GQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGAL 295
G +T EA S+ + IYS SWGP DDGKT+ P L ++A GV GR G++
Sbjct: 247 GDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSV 306
Query: 296 YVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSG-- 353
+V+ASGNGG D C+ DGYTNSI++I++ + G P Y E CS+ + TYSSG
Sbjct: 307 FVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYD 366
Query: 354 NYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHD 413
I TTDL ++C++ H GTSA+AP+AAGI L LEANP LTWRDVQ++ + +S + +
Sbjct: 367 KKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNA 426
Query: 414 GKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI 473
W+ A G + SH YGFG +DA +V A+ W V Q T + ++I + V
Sbjct: 427 NDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQIKTIRPNSAVR 486
Query: 474 ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNR 533
+ + ++ LEHV V + I P RG + + L SP G S L R D +
Sbjct: 487 SIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSM 546
Query: 534 YGFQNWTFMSVAHWGSSGVGSWKLKVKST-----HDNEIVTLKSWRLKMFGETI 582
GF+NW FM++ WG G W L+V T + LK W L ++G ++
Sbjct: 547 EGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSV 600
>Hs20336192 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 497
Score = 331 bits (849), Expect = 2e-90
Identities = 177/426 (41%), Positives = 245/426 (56%), Gaps = 6/426 (1%)
Query: 141 NDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGSWDFNDNNPLPKPRL--- 197
+++NV WK TG VV ++DDG++ + DL N+ S+D N N+ P PR
Sbjct: 15 SEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDAS 74
Query: 198 KDDYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILSGQITAEDEAASLIYGLDVNDI 256
++ HGTRCAGE+AA N+ C VG+AYN+K+ GIR+L G +T EA SL + DI
Sbjct: 75 NENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYIDI 134
Query: 257 YSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASGNGGMFGDSCNFDGYT 316
YS SWGP DDGKT+ P L K+A G+ +GR G+++V+ASGNGG GD C+ DGYT
Sbjct: 135 YSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGYT 194
Query: 317 NSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS--GNYIKTTDLDEKCSNTHGGTSA 374
NSI++I+V + G P Y E C++ + TYSSG+ I TTDL ++C++ H GTS
Sbjct: 195 NSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTSV 254
Query: 375 AAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHDGKWQDTAMGKRYSHTYGFGKL 434
+AP+ AGI L LEAN LTWRDVQ+L + +S + W+ G + SH YGFG +
Sbjct: 255 SAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGLV 314
Query: 435 DAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVIESTVSVSAEEFKQNNLKRLEH 494
DA +V AK W V Q + +SI + + ++ + E + LEH
Sbjct: 315 DAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLEH 374
Query: 495 VTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNRYGFQNWTFMSVAHWGSSGVGS 554
V V I P RG + + L+SP G S L R LD + GF NW FM+V WG G
Sbjct: 375 VVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEGQ 434
Query: 555 WKLKVK 560
W L+++
Sbjct: 435 WTLEIQ 440
>CE11736 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 699
Score = 317 bits (812), Expect = 4e-86
Identities = 182/471 (38%), Positives = 259/471 (54%), Gaps = 22/471 (4%)
Query: 124 DPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGS 183
DPL+ QW+L G D+NV W + G V +++DDG+ ++ DL N+ S
Sbjct: 162 DPLYKDQWYLHGGAVGGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLAS 221
Query: 184 WDFNDNNPLPKPRLK-DDYHGTRCAGEIAAFR-NDICGVGVAYNSKVSGIRILSGQITAE 241
D ND++ P P+ D+ HGTRCAGE+AA N+ CGVGVA+ +K+ G+R+L G ++
Sbjct: 222 TDINDHDDDPTPQNNGDNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDS 281
Query: 242 DEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASG 301
EAASL D DIYS SWGP DDGKT P L ++A +G+ GR KG ++V+ASG
Sbjct: 282 VEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASG 341
Query: 302 NGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGNY--IKTT 359
NGG DSC+ DGYT S++++++ + + P Y E C + + TYSS I T
Sbjct: 342 NGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTV 401
Query: 360 DLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSE----EINPHDGK 415
D+ C++ H GTSA+APLAAGI L LEANP LTWRD+Q+L + ++ E NP
Sbjct: 402 DVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNP---G 458
Query: 416 WQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI-- 473
W +G+ S+ +G+G +D +V+MAK+W V Q ++ T + + N ++
Sbjct: 459 WSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQ---HICTYEYRLANPNPRPIVGR 515
Query: 474 ---ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLD 530
T+ V+ E + LEHV V + RG + + L SP G S L R D
Sbjct: 516 FQLNFTLDVNGCE-SGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQD 574
Query: 531 KNRYGFQNWTFMSVAHWGSSGVGSWKLKVKSTHDNEIV--TLKSWRLKMFG 579
N GF W F+SV WG G+W L V+S N T W L ++G
Sbjct: 575 FNANGFHKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATGTFHDWTLLLYG 625
>CE11734 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 942
Score = 317 bits (812), Expect = 4e-86
Identities = 182/471 (38%), Positives = 259/471 (54%), Gaps = 22/471 (4%)
Query: 124 DPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGS 183
DPL+ QW+L G D+NV W + G V +++DDG+ ++ DL N+ S
Sbjct: 162 DPLYKDQWYLHGGAVGGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLAS 221
Query: 184 WDFNDNNPLPKPRLK-DDYHGTRCAGEIAAFR-NDICGVGVAYNSKVSGIRILSGQITAE 241
D ND++ P P+ D+ HGTRCAGE+AA N+ CGVGVA+ +K+ G+R+L G ++
Sbjct: 222 TDINDHDDDPTPQNNGDNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDS 281
Query: 242 DEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASG 301
EAASL D DIYS SWGP DDGKT P L ++A +G+ GR KG ++V+ASG
Sbjct: 282 VEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASG 341
Query: 302 NGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGNY--IKTT 359
NGG DSC+ DGYT S++++++ + + P Y E C + + TYSS I T
Sbjct: 342 NGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTV 401
Query: 360 DLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSE----EINPHDGK 415
D+ C++ H GTSA+APLAAGI L LEANP LTWRD+Q+L + ++ E NP
Sbjct: 402 DVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNP---G 458
Query: 416 WQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI-- 473
W +G+ S+ +G+G +D +V+MAK+W V Q ++ T + + N ++
Sbjct: 459 WSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQ---HICTYEYRLANPNPRPIVGR 515
Query: 474 ---ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLD 530
T+ V+ E + LEHV V + RG + + L SP G S L R D
Sbjct: 516 FQLNFTLDVNGCE-SGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQD 574
Query: 531 KNRYGFQNWTFMSVAHWGSSGVGSWKLKVKSTHDNEIV--TLKSWRLKMFG 579
N GF W F+SV WG G+W L V+S N T W L ++G
Sbjct: 575 FNANGFHKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATGTFHDWTLLLYG 625
>CE11732 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 827
Score = 317 bits (812), Expect = 4e-86
Identities = 182/471 (38%), Positives = 259/471 (54%), Gaps = 22/471 (4%)
Query: 124 DPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGS 183
DPL+ QW+L G D+NV W + G V +++DDG+ ++ DL N+ S
Sbjct: 162 DPLYKDQWYLHGGAVGGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLAS 221
Query: 184 WDFNDNNPLPKPRLK-DDYHGTRCAGEIAAFR-NDICGVGVAYNSKVSGIRILSGQITAE 241
D ND++ P P+ D+ HGTRCAGE+AA N+ CGVGVA+ +K+ G+R+L G ++
Sbjct: 222 TDINDHDDDPTPQNNGDNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDS 281
Query: 242 DEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASG 301
EAASL D DIYS SWGP DDGKT P L ++A +G+ GR KG ++V+ASG
Sbjct: 282 VEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASG 341
Query: 302 NGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGNY--IKTT 359
NGG DSC+ DGYT S++++++ + + P Y E C + + TYSS I T
Sbjct: 342 NGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTV 401
Query: 360 DLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSE----EINPHDGK 415
D+ C++ H GTSA+APLAAGI L LEANP LTWRD+Q+L + ++ E NP
Sbjct: 402 DVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNP---G 458
Query: 416 WQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI-- 473
W +G+ S+ +G+G +D +V+MAK+W V Q ++ T + + N ++
Sbjct: 459 WSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQ---HICTYEYRLANPNPRPIVGR 515
Query: 474 ---ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLD 530
T+ V+ E + LEHV V + RG + + L SP G S L R D
Sbjct: 516 FQLNFTLDVNGCE-SGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQD 574
Query: 531 KNRYGFQNWTFMSVAHWGSSGVGSWKLKVKSTHDNEIV--TLKSWRLKMFG 579
N GF W F+SV WG G+W L V+S N T W L ++G
Sbjct: 575 FNANGFHKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATGTFHDWTLLLYG 625
>CE11730 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 730
Score = 317 bits (812), Expect = 4e-86
Identities = 182/471 (38%), Positives = 259/471 (54%), Gaps = 22/471 (4%)
Query: 124 DPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGS 183
DPL+ QW+L G D+NV W + G V +++DDG+ ++ DL N+ S
Sbjct: 162 DPLYKDQWYLHGGAVGGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLAS 221
Query: 184 WDFNDNNPLPKPRLK-DDYHGTRCAGEIAAFR-NDICGVGVAYNSKVSGIRILSGQITAE 241
D ND++ P P+ D+ HGTRCAGE+AA N+ CGVGVA+ +K+ G+R+L G ++
Sbjct: 222 TDINDHDDDPTPQNNGDNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDS 281
Query: 242 DEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASG 301
EAASL D DIYS SWGP DDGKT P L ++A +G+ GR KG ++V+ASG
Sbjct: 282 VEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASG 341
Query: 302 NGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGNY--IKTT 359
NGG DSC+ DGYT S++++++ + + P Y E C + + TYSS I T
Sbjct: 342 NGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTV 401
Query: 360 DLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSE----EINPHDGK 415
D+ C++ H GTSA+APLAAGI L LEANP LTWRD+Q+L + ++ E NP
Sbjct: 402 DVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNP---G 458
Query: 416 WQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI-- 473
W +G+ S+ +G+G +D +V+MAK+W V Q ++ T + + N ++
Sbjct: 459 WSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQ---HICTYEYRLANPNPRPIVGR 515
Query: 474 ---ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLD 530
T+ V+ E + LEHV V + RG + + L SP G S L R D
Sbjct: 516 FQLNFTLDVNGCE-SGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQD 574
Query: 531 KNRYGFQNWTFMSVAHWGSSGVGSWKLKVKSTHDNEIV--TLKSWRLKMFG 579
N GF W F+SV WG G+W L V+S N T W L ++G
Sbjct: 575 FNANGFHKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATGTFHDWTLLLYG 625
>CE11728 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 670
Score = 317 bits (812), Expect = 4e-86
Identities = 182/471 (38%), Positives = 259/471 (54%), Gaps = 22/471 (4%)
Query: 124 DPLFDQQWHLINPNYPGNDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGS 183
DPL+ QW+L G D+NV W + G V +++DDG+ ++ DL N+ S
Sbjct: 162 DPLYKDQWYLHGGAVGGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLAS 221
Query: 184 WDFNDNNPLPKPRLK-DDYHGTRCAGEIAAFR-NDICGVGVAYNSKVSGIRILSGQITAE 241
D ND++ P P+ D+ HGTRCAGE+AA N+ CGVGVA+ +K+ G+R+L G ++
Sbjct: 222 TDINDHDDDPTPQNNGDNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDS 281
Query: 242 DEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASG 301
EAASL D DIYS SWGP DDGKT P L ++A +G+ GR KG ++V+ASG
Sbjct: 282 VEAASLSLNQDHIDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASG 341
Query: 302 NGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGNY--IKTT 359
NGG DSC+ DGYT S++++++ + + P Y E C + + TYSS I T
Sbjct: 342 NGGSRQDSCSADGYTTSVYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTV 401
Query: 360 DLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSE----EINPHDGK 415
D+ C++ H GTSA+APLAAGI L LEANP LTWRD+Q+L + ++ E NP
Sbjct: 402 DVPGGCTDKHTGTSASAPLAAGIIALALEANPELTWRDMQHLVLRTANWKPLENNP---G 458
Query: 416 WQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVI-- 473
W +G+ S+ +G+G +D +V+MAK+W V Q ++ T + + N ++
Sbjct: 459 WSRNGVGRMVSNKFGYGLIDGGALVNMAKTWKTVPEQ---HICTYEYRLANPNPRPIVGR 515
Query: 474 ---ESTVSVSAEEFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLD 530
T+ V+ E + LEHV V + RG + + L SP G S L R D
Sbjct: 516 FQLNFTLDVNGCE-SGTPVLYLEHVQVHATVRYLKRGDLKLTLFSPSGTRSVLLPPRPQD 574
Query: 531 KNRYGFQNWTFMSVAHWGSSGVGSWKLKVKSTHDNEIV--TLKSWRLKMFG 579
N GF W F+SV WG G+W L V+S N T W L ++G
Sbjct: 575 FNANGFHKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATGTFHDWTLLLYG 625
>CE17654 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 760
Score = 313 bits (801), Expect = 8e-85
Identities = 159/341 (46%), Positives = 219/341 (63%), Gaps = 11/341 (3%)
Query: 123 SDPLFDQQWHLINPNYPGN-----DVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDN 177
+DPL+ W+L + + D NV W TG GVV ++DDGL+ + D+ N
Sbjct: 175 NDPLWTDMWYLNRGEHHSDSTTRMDHNVKEAWDLGYTGKGVVVTILDDGLERTHPDISPN 234
Query: 178 FCVEGSWDFND--NNPLPKPRLKDDY-HGTRCAGEIAA-FRNDICGVGVAYNSKVSGIRI 233
+ S+D ND N+P+P+ D+ HGTRCAGE+AA F N +C VG+AYN+ + GIR+
Sbjct: 235 YDERASYDVNDRDNDPMPRYEFSDENRHGTRCAGEVAAIFNNSLCIVGIAYNANIGGIRM 294
Query: 234 LSGQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKG 293
L G +T EAAS+ + D DIYS SWGP DDG+T+ P L + A KG+T GR KG
Sbjct: 295 LDGDVTDAVEAASVGHNADYIDIYSASWGPDDDGRTVDGPAKLTRSAFEKGITMGRKGKG 354
Query: 294 ALYVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS- 352
+++V+ASGNGG DSCN DGYTNSI+++++ + G P YSE+CS+ + TYSSG+
Sbjct: 355 SIFVWASGNGGKDADSCNCDGYTNSIYTLSISSATENGNIPWYSEACSSTLATTYSSGAT 414
Query: 353 -GNYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINP 411
I TTDL C+N H GTSA+APLAAGI L LEANPNLTWRD+Q++ I +++ IN
Sbjct: 415 GEKMILTTDLHHACTNMHTGTSASAPLAAGIVALALEANPNLTWRDLQHIVIRTAKPINL 474
Query: 412 HDGKWQDTAMGKRYSHTYGFGKLDAYNIVHMAKSWINVNPQ 452
G W +G+ SH++G+G +DA +V +AK W V+ Q
Sbjct: 475 RAGDWTTNGVGRNVSHSFGYGLMDAGAMVKLAKIWKKVDEQ 515
Score = 70.9 bits (172), Expect = 7e-12
Identities = 36/96 (37%), Positives = 52/96 (53%), Gaps = 5/96 (5%)
Query: 486 QNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNRYGFQNWTFMSVA 545
+N + +EHV V + AP RG + + L SP G STL T R D +R GF +W FM+
Sbjct: 618 ENKVSYVEHVQAIVTLKAPKRGDLQIYLTSPSGTKSTLLTKRARDTSRSGFTDWAFMTTH 677
Query: 546 HWGSSGVGSWKLKVKST--HDNEIVTLKSWRLKMFG 579
+WG G W L++ + D E+V W L ++G
Sbjct: 678 NWGEQAAGLWILEIDNDGWDDAELV---KWELVLYG 710
>CE08941 [O] KOG3526 Subtilisin-like proprotein convertase
Length = 556
Score = 285 bits (728), Expect = 2e-76
Identities = 169/439 (38%), Positives = 247/439 (55%), Gaps = 38/439 (8%)
Query: 176 DNFCVEGSWDFNDNNPLPKPRLKDDY---HGTRCAGEIAAFR-NDICGVGVAYNSKVSGI 231
D+ E S+DF+ N+P P PR DD+ HGTRCAGEI A R N +CGVGVAY+ KV+GI
Sbjct: 90 DDENAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGI 149
Query: 232 RILSGQ-ITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRD 290
R+L +T EA S+ + IYS SWGP+DDGKT+ P +AI++GV EGR+
Sbjct: 150 RMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRN 209
Query: 291 AKGALYVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSS 350
G+++V+ASG+GG D CN DGY S+++I++ + G + Y ESCS+ + T+S+
Sbjct: 210 GLGSIFVWASGDGGE-DDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSN 268
Query: 351 GSGNY---IKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSE 407
G N + TTDL +C+ +H GTSAAAP AAG++ L LEANP+LTWRD+Q+L++L+S
Sbjct: 269 GGRNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSS 328
Query: 408 EINPHDGK------------------------WQDTAMGKRYSHTYGFGKLDAYNIVHMA 443
+ DG+ WQ +G Y+H +GFG LDA +V +A
Sbjct: 329 RNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLA 388
Query: 444 KSWINVNPQGWLYLPTIVEKQSISNSDEVIESTVSVSAEEFKQNNLKRLEHVTVTVDIDA 503
+W +P + +++ +D + ++ Q ++ LEHV V ++
Sbjct: 389 MAW-KTSPPRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYLEHVQAVVSFNS 447
Query: 504 PYRGHVLVDLISPDGVTSTLATARRL--DKNRYGFQNWTFMSVAHWGSSGVGSWKLKVKS 561
RG + LISP G T T+ +RR D ++ GF NW FM+ WG + G W+L +
Sbjct: 448 TRRGDTTLYLISPMG-TRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVARF 506
Query: 562 THDN-EIVTLKSWRLKMFG 579
TLK + L + G
Sbjct: 507 QGPGAHAGTLKKFELMLHG 525
>CE28554 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 537
Score = 255 bits (652), Expect = 2e-67
Identities = 161/456 (35%), Positives = 247/456 (53%), Gaps = 32/456 (7%)
Query: 133 LINPNYPGNDVNVTG------LWKENITGYGVVAALVDDGLDYENEDLKDNFCVEGSWDF 186
+ N YP + N+T W++ V A+VDDG+D ++ DLK F S+DF
Sbjct: 102 MTNKGYPVHVWNLTPSLYIREAWEDGFNASRVTVAVVDDGVDIKHVDLKSAFSPRVSFDF 161
Query: 187 NDNNPLPKPRLKDDY-HGTRCAGEIAAFRNDICGVGVAYNSKVSGIRILSGQITAED--E 243
LP P+ ++ HGT+CAG + A CG+GV + + + I++L GQ D E
Sbjct: 162 VRFGDLPTPKNSKEFEHGTQCAG-LVAMEGQQCGLGVGHGATLGAIKLL-GQDFLNDALE 219
Query: 244 AASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGALYVFASGNG 303
+L + D+ DIYS SWGP DDGK+ + P ++AI G GR+ KG ++V+ASGNG
Sbjct: 220 GDALAFQKDLIDIYSVSWGPKDDGKSAEKPAKFTEEAIKNGALHGRNGKGNIFVWASGNG 279
Query: 304 GMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGSGNYIKTTDLDE 363
G+ GD+C +DGY ++ ++++ G ID G Y E CS+V+ SG I+TT L+
Sbjct: 280 GVNGDNCAYDGYVSNEYTLSFGVIDASGAPAAYGEGCSSVLAAV--SGGDAMIQTTGLES 337
Query: 364 KCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHDGKWQDTAMGK 423
CS+ G+SA+A +A+GI +LVL+ANP L+ RD+Q+L +S D + + + G
Sbjct: 338 TCSSI-SGSSASAAIASGIISLVLDANPTLSQRDIQHLIARTSNASAIRDVELYENSAGL 396
Query: 424 RYSHTYGFGKLDAYNIVHMAKSWINVNPQGWLYLPTIVEKQSISNSDEVIESTVSVSAEE 483
+ GFG L+A +V MA +W NV PQ EK +++N +I+++
Sbjct: 397 NFHPKVGFGLLNAQKLVVMAATWENVAPQ------VTCEKMNLANG--IIDNS------- 441
Query: 484 FKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNRYGFQNWTFMS 543
++ ++E V V+ I P+RG V + L SP G S L R D +R +W F+S
Sbjct: 442 --DCDVTKVERVIVSGSIIHPHRGQVQIRLESPRGTISELLPLRPKDTSR-DLLDWNFVS 498
Query: 544 VAHWGSSGVGSWKLKVKSTHDNEIVTLKSWRLKMFG 579
V +G + G WKL V S D+ ++ K+ G
Sbjct: 499 VNFFGENSRGIWKLHVTSEEDDVDFRVEMKMFKVVG 534
>Hs20336186 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 487
Score = 255 bits (651), Expect = 2e-67
Identities = 134/311 (43%), Positives = 189/311 (60%), Gaps = 9/311 (2%)
Query: 123 SDPLFDQQWHLINPNYPG---NDVNVTGLWKENITGYGVVAALVDDGLDYENEDLKDNFC 179
+DP++ W+L + +++NV WK TG VV ++DDG++ + DL N+
Sbjct: 161 NDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYD 220
Query: 180 VEGSWDFNDNNPLPKPRL---KDDYHGTRCAGEIAAFRND-ICGVGVAYNSKVSGIRILS 235
S+D N N+ P PR ++ HGTRCAGE+AA N+ C VG+AYN+K+ GIR+L
Sbjct: 221 SYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLD 280
Query: 236 GQITAEDEAASLIYGLDVNDIYSCSWGPSDDGKTMQAPDTLVKKAIIKGVTEGRDAKGAL 295
G +T EA SL + DIYS SWGP DDGKT+ P L K+A G+ +GR G++
Sbjct: 281 GDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSI 340
Query: 296 YVFASGNGGMFGDSCNFDGYTNSIFSITVGAIDWKGLHPPYSESCSAVMVVTYSSGS--G 353
+V+ASGNGG GD C+ DGYTNSI++I+V + G P Y E C++ + TYSSG+
Sbjct: 341 FVWASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYE 400
Query: 354 NYIKTTDLDEKCSNTHGGTSAAAPLAAGIYTLVLEANPNLTWRDVQYLSILSSEEINPHD 413
I TTDL ++C++ H GTS +AP+ AGI L LEAN LTWRDVQ+L + +S +
Sbjct: 401 RKIVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKA 460
Query: 414 GKWQDTAMGKR 424
W+ G +
Sbjct: 461 SDWKVNGAGHK 471
>Hs20484562 [O] KOG3525 Subtilisin-like proprotein convertase
Length = 271
Score = 72.4 bits (176), Expect = 2e-12
Identities = 35/104 (33%), Positives = 57/104 (54%), Gaps = 2/104 (1%)
Query: 483 EFKQNNLKRLEHVTVTVDIDAPYRGHVLVDLISPDGVTSTLATARRLDKNRYGFQNWTFM 542
+ + + LK LEHV VTV I P RG + + L P G+ S + T +D + GF +WTF
Sbjct: 2 DLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPRGMMSLIGTPGSMDSDPNGFNDWTFS 61
Query: 543 SVAHWGSSGVGSWKLKVKSTHDN--EIVTLKSWRLKMFGETIDA 584
+V WG G+++L ++ D ++ L+ W+L ++G A
Sbjct: 62 TVRCWGERARGTYRLVIRDVGDESFQVGILRQWQLTLYGSVWSA 105
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.314 0.133 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,574,765
Number of Sequences: 60738
Number of extensions: 2032792
Number of successful extensions: 4309
Number of sequences better than 1.0e-05: 30
Number of HSP's better than 0.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 4139
Number of HSP's gapped (non-prelim): 36
length of query: 756
length of database: 30,389,216
effective HSP length: 114
effective length of query: 642
effective length of database: 23,465,084
effective search space: 15064583928
effective search space used: 15064583928
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)