ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV4896 check: MH TZ KOG1703 Cytoskeleton Adaptor protein Enigma and related PDZ-LIM proteins
r_klactIV4896 check: MH TZ KOG1703 Signal transduction mechanisms Adaptor protein Enigma and related PDZ-LIM proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV4896 1683015 1680046 -990
(990 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDL240w_1 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LI... 604 e-172
SPBC3F6.05_1 [TZ] KOG1703 Adaptor protein Enigma and related PDZ... 260 8e-69
YDL240w_2 [TZ] KOG2710 Rho GTPase-activating protein 244 4e-64
SPBC3F6.05_2 [TZ] KOG2710 Rho GTPase-activating protein 166 2e-40
Hs21361591 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-L... 88 8e-17
HsM7706250 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-L... 87 2e-16
7291703 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM ... 82 5e-15
Hs7662242 [T] KOG4270 GTPase-activator protein 79 5e-14
Hs4758670 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LI... 77 1e-13
Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 75 4e-13
Hs7382484 [TZ] KOG2710 Rho GTPase-activating protein 75 5e-13
Hs7382482 [TZ] KOG2710 Rho GTPase-activating protein 75 5e-13
Hs7382480 [TZ] KOG2710 Rho GTPase-activating protein 75 5e-13
Hs7382478 [TZ] KOG2710 Rho GTPase-activating protein 75 5e-13
Hs4502223 [TZ] KOG2710 Rho GTPase-activating protein 75 5e-13
CE03768 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 75 5e-13
CE26357 [R] KOG4407 Predicted Rho GTPase-activating protein 74 9e-13
Hs21264597 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 74 1e-12
Hs16975484 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 74 1e-12
Hs5902012_2 [T] KOG1453 Chimaerin and related Rho GTPase activat... 72 3e-12
CE23779_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 72 4e-12
Hs4757766 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 72 6e-12
Hs13775230 [T] KOG4270 GTPase-activator protein 72 6e-12
Hs7661858 [TZ] KOG2710 Rho GTPase-activating protein 71 7e-12
CE27576 [TZ] KOG2710 Rho GTPase-activating protein 70 1e-11
CE11336 [TZ] KOG2710 Rho GTPase-activating protein 70 1e-11
CE01828 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM ... 70 2e-11
Hs21361736 [T] KOG4270 GTPase-activator protein 69 3e-11
7294614 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 69 3e-11
CE06642 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 68 6e-11
CE06641 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 68 6e-11
Hs21314774 [T] KOG4724 Predicted Rho GTPase-activating protein 68 8e-11
Hs20270373 [T] KOG4724 Predicted Rho GTPase-activating protein 68 8e-11
Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 68 8e-11
SPBC28E12.03_2 [T] KOG1453 Chimaerin and related Rho GTPase acti... 68 8e-11
Hs22065906 [T] KOG4724 Predicted Rho GTPase-activating protein 67 1e-10
Hs21361124 [TZR] KOG1704 FOG: LIM domain 67 1e-10
Hs4506345 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LI... 66 2e-10
7304324 [TZ] KOG2710 Rho GTPase-activating protein 66 2e-10
HsM4503723 [TZR] KOG1704 FOG: LIM domain 66 3e-10
7299033 [TZ] KOG2272 Focal adhesion protein PINCH-1 contains LIM... 66 3e-10
HsM19923515 [T] KOG4270 GTPase-activator protein 65 4e-10
7298768 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM ... 65 7e-10
7298573 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM ... 65 7e-10
Hs22050706 [T] KOG4271 Rho-GTPase activating protein 64 9e-10
7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr 64 9e-10
Hs11641401 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 64 1e-09
Hs22045949 [T] KOG1449 Predicted Rho GTPase-activating protein C... 64 2e-09
Hs20536040 [T] KOG4270 GTPase-activator protein 62 3e-09
Hs4758750_2 [T] KOG1453 Chimaerin and related Rho GTPase activat... 62 3e-09
Hs15147252 [T] KOG4270 GTPase-activator protein 62 6e-09
Hs11038641 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 62 6e-09
Hs11038639 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 62 6e-09
CE00918 [T] KOG1450 Predicted Rho GTPase-activating protein 61 8e-09
HsM16975482 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ... 61 1e-08
Hs7657307 [T] KOG1701 Focal adhesion adaptor protein Paxillin an... 61 1e-08
Hs21264594 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 61 1e-08
Hs21264592 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 61 1e-08
SPAC29A4.11_2 [T] KOG1453 Chimaerin and related Rho GTPase activ... 61 1e-08
Hs21264337_1 [TZ] KOG1117 Rho- and Arf-GTPase activating protein... 60 1e-08
HsM7019433 [R] KOG3564 GTPase-activating protein 60 2e-08
Hs21361397 [R] KOG3564 GTPase-activating protein 60 2e-08
Hs14249622 [T] KOG1701 Focal adhesion adaptor protein Paxillin a... 60 2e-08
7300563 [T] KOG4270 GTPase-activator protein 60 2e-08
Hs20977541 [R] KOG4407 Predicted Rho GTPase-activating protein 60 2e-08
Hs11496885 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-L... 59 3e-08
Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein 59 4e-08
Hs13491176 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 59 4e-08
Hs10835201 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 58 6e-08
YDR379w_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 58 8e-08
SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein 57 1e-07
CE15896 [TZR] KOG1704 FOG: LIM domain 57 1e-07
CE15895 [TZR] KOG1704 FOG: LIM domain 57 1e-07
7290597 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 57 1e-07
CE18872 [R] KOG3564 GTPase-activating protein 57 2e-07
CE04392 [TZ] KOG2272 Focal adhesion protein PINCH-1 contains LIM... 56 3e-07
Hs16445031 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 55 4e-07
CE17831 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 55 4e-07
CE01007 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 55 4e-07
Hs7661882 [T] KOG4270 GTPase-activator protein 55 5e-07
Hs22055163 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-L... 55 5e-07
Hs19924173 [TZR] KOG1704 FOG: LIM domain 55 5e-07
CE16059 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr 54 9e-07
7292937 [T] KOG1701 Focal adhesion adaptor protein Paxillin and ... 54 9e-07
7302107 [T] KOG1452 Predicted Rho GTPase-activating protein 54 1e-06
YOR127w_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 54 1e-06
Hs7656904 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 54 2e-06
Hs5453714 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LI... 54 2e-06
Hs22056100_1 [TZ] KOG2710 Rho GTPase-activating protein 54 2e-06
Hs7662330 [TZ] KOG1044 Actin-binding LIM Zn-finger protein Limat... 52 3e-06
CE21517 [T] KOG4270 GTPase-activator protein 52 3e-06
ECU05g0710 [TZ] KOG2710 Rho GTPase-activating protein 52 5e-06
Hs7706107 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 52 6e-06
Hs7661982 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 52 6e-06
YBR260c [T] KOG1450 Predicted Rho GTPase-activating protein 51 8e-06
Hs5174427 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 51 8e-06
Hs14765644 [T] KOG1453 Chimaerin and related Rho GTPase activati... 51 8e-06
At5g61530 [T] KOG4270 GTPase-activator protein 51 8e-06
>YDL240w_1 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 746
Score = 604 bits (1557), Expect = e-172
Identities = 327/753 (43%), Positives = 448/753 (59%), Gaps = 49/753 (6%)
Query: 27 TESYMAVKSKSSPRPTRQCADCKKPIHSNA------LKALGSHYHENCLVCYDCGAICKP 80
T S M V+ K+ + CA C K + ++ LKALG +YHE+C C DC KP
Sbjct: 13 TASPMTVQVKNQKKI---CARCNKLVIPDSQRTKTTLKALGKYYHESCFTCQDCQKPLKP 69
Query: 81 KYFPYDLPDSKETVLLCQKHYFTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGE 140
KYFPY + + E++LLCQ YF R+NLLC VC PL G+Y+ FG YDE+HF C++C
Sbjct: 70 KYFPYQVDKTSESILLCQYDYFRRHNLLCHVCDTPLRGLYYTAFGYRYDEEHFSCTICAT 129
Query: 141 KCKVDECFHHYDNLYCKYHFLKYLSRRCEGCGYPISDQYIEFQKGDKMECWHTECYGIHK 200
C V +CF + + LYCKYHFLKY S+RC+GC +PISDQYIEF KG+++ CWH ECYGIHK
Sbjct: 130 PCGVKKCFMYGNQLYCKYHFLKYFSKRCKGCEFPISDQYIEFPKGEEIHCWHPECYGIHK 189
Query: 201 YWHVTISPEDFGLPNLKVYRIEEYNAENDNHPDLKEMDCNILTFNKTLSKIWTVLYRFEE 260
YWHV ++ E GL L + + D +P E+D + FN LSK W+VLYRFEE
Sbjct: 190 YWHVNLAAETVGLQYLPKLEYNPNSGDKDINPTAYELDKQMQAFNFILSKTWSVLYRFEE 249
Query: 261 ETANCVSDMFQYLTGLDQNNGLDASALLVLKVSCLLKAIDSLDTLRIYQTKLSFSANDHP 320
E A+C+SDMFQYLT DQ G++++ LLVLK+ CL + +D+ L+ S N
Sbjct: 250 EAASCISDMFQYLTSNDQLKGIESTGLLVLKIDCLFRGLDT----------LNLSTNKSM 299
Query: 321 GLRSDQKL----KTFIKMQTKIPNKLSTKIMIYLQLLRKITXXXXXXXXXXXXXFISVIT 376
+ SDQ+ +K P LSTKIMIYLQLLRK+ F+SVIT
Sbjct: 300 PVNSDQECIENNAMAASKYSKFPKNLSTKIMIYLQLLRKL-GTENKNETITISSFMSVIT 358
Query: 377 GIAQFLKLLIRDSLTNALEYCKMTKSSSALLKYLREIEKNEDYQEQPFEYINITINATDS 436
G+A FLKLL R L ALE K+T S + LL++LRE+EKNE ++ PF+YI +NATDS
Sbjct: 359 GLAHFLKLLTRFGLYTALENNKLTHSVNPLLRFLREVEKNELFENNPFQYIKTPVNATDS 418
Query: 437 CTYCGKYIKDACIKHGIRRWHKECLRCSVCNKFIDNHELSEAAYNDKTSEVHCGRCSVDD 496
C C KYI++ CI+ RWH C CS C+K I+ L++ +N + ++ C CS+DD
Sbjct: 419 CAGCNKYIQEECIQFYEHRWHIACFTCSSCHKNINPRSLTDPTFNKEKKKILCSHCSIDD 478
Query: 497 PNSKVGFKSVSCLEQLIFLLQIALVRSKTVMKYNSDYANTSKNAIRNKSMQQ-TYIRTLN 555
P S GFK V+ L QLIFLL+IALV+S+TVM + +N++++ +++ TYIRTLN
Sbjct: 479 PASVPGFKFVTKLAQLIFLLKIALVKSRTVMLKSKASNKVGRNSLQSTMLKEHTYIRTLN 538
Query: 556 DVKRLKYRRTSMKVSCNKEEVRQSRVIETEERRVDQDI--AGEKDLVIQTD----QRNIK 609
D+KRL+ RR S++V+ NK++ R+S ++ET E ++ K+LVIQTD + +
Sbjct: 539 DIKRLRSRRESVRVTHNKQQARKSVILETAETDLNDPTKQGDSKNLVIQTDDPSSSQQVS 598
Query: 610 KQSTIFEGTKSLTLDDISRIVATEKSRELIPGT---NKDFTASGDNVPTKKATNSNIYYS 666
+ +F TK+LTLDDISRIVA E++REL P K + D S +YYS
Sbjct: 599 TRENVFSNTKTLTLDDISRIVAAEQARELRPNAFAHFKKLKETDDETSNVVPKKSGVYYS 658
Query: 667 ELTSEQYYILQIIAFSLLNSEGFDMQQIKPPD----------FPHKMSNNNGLWTKFKTI 716
EL++ + +++ I+ SLL + Q I D F ++ W + K I
Sbjct: 659 ELSTMELSMIRAISLSLLAGK----QLISKTDPNYTSLVSMVFSNEKQVTGSFWNRMK-I 713
Query: 717 MGGXXXXXXXXXXVFGTPLEYLTSHCGVESDLG 749
M VFG PL+ L GV+SDLG
Sbjct: 714 MMSMEPKKPITKTVFGAPLDVLCEKWGVDSDLG 746
>SPBC3F6.05_1 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 858
Score = 260 bits (664), Expect = 8e-69
Identities = 210/817 (25%), Positives = 354/817 (42%), Gaps = 123/817 (15%)
Query: 13 NGQLPNTEEVLPNRTESYMAVKSKSSPRPTRQCADCKKPIHSNALKALGSHYHENCLVCY 72
+G L E+ R+++ + K+ ++ CA C + I ++ALG+ YH C C+
Sbjct: 84 SGLLNKEEQQSLKRSDTSVFPKAVRKVSSSKICASCGQVISGQYVRALGNIYHLECFRCH 143
Query: 73 DCGAICKPKYFPYDLPDSKETVLLCQKHYFTRNNLLCSVCKEPLSGIYFNTFGKLYDEQH 132
DC ++ K+FP D P + V LC+ YF R +LLC+ C L G Y K + +H
Sbjct: 144 DCNSLVASKFFPIDDPTLNKQVPLCETDYFRRLDLLCASCGMALRGYYITALNKKFHIEH 203
Query: 133 FCCSLCGEKCKVDECFHHYD-NLYCKYHFLKYLSRRCEGCGYPISDQYIEFQKGDKMECW 191
F CSLC ++ ++ Y+ +YC YH+ + RC GC PI Q++E + + W
Sbjct: 204 FTCSLCYTVFGPNDSYYEYEGKVYCHYHYSTLFAARCCGCDGPILRQFVEVYRNGVSQNW 263
Query: 192 HTECYGIHKYWHVTISPEDFGLPNLKVYRIEEYNAENDNHPDLKEMDCNILTFNKTLSKI 251
H C+ I+K+W+V + + E + + D+ ++ + + I
Sbjct: 264 HVPCHMIYKFWNVKLCQK----------TSIETSKKKDSELSQSQLRKREKHLEQKIFHI 313
Query: 252 WTVLYRFEEETANCVSDMFQYLTGLDQNNGLDASALLVLKVSCLLKAIDSLDTLRIYQTK 311
W L FEE TA+C+SDM ++ + + + + + L K IDSL+T+
Sbjct: 314 WHALSYFEEYTASCISDMLLLVSNGEFTKSVICAQKFIRYIEILFKGIDSLETI-----L 368
Query: 312 LSFSANDHPGLRSDQKLKTFIKMQTKIPNKLSTKIMIYLQLLRKITXXXXXXXXXXXXXF 371
SF A P +R + KL L K++ LL K F
Sbjct: 369 SSFHAKSMPYVR-EAKL-------------LCKKLVSIFALLAK-CHNSDIRDVAIVQDF 413
Query: 372 ISVITGIAQFLKLLIRDSLTNALEYCKMTKSSSALLKYLREIEK-----NEDYQEQPFEY 426
+S+ TG+A +LKLLIR SLT L + AL ++L+ +E+ E Y F+
Sbjct: 414 LSLFTGLAHYLKLLIRISLTGGLRLEQDHACKHALPQFLQTVEEARFVDQEGYDSSSFDM 473
Query: 427 -INITINATDSCTYCGKYIKDACIKHGIRRWHKECLRCSVCNKFIDNHELSEAAYNDKTS 485
+N+ ++D C C +++ C+ G R H CL C+ C K+ + A +N++T
Sbjct: 474 PLNLANASSDLCYVCHSALEEDCVLLGEIRCHIGCLSCTKC-KYNNRENYDWARWNNQTK 532
Query: 486 EVHCGRC-----SVDDPNSKVGFKSVSCLEQLIFLLQIALVRSKTVMKYNSDYA------ 534
++ C C +V + F+ VS L Q I+LL+IALVR T++ N+D +
Sbjct: 533 QIECYLCYTESSNVSNDEPHPSFEYVSRLSQYIYLLRIALVRLYTILMENNDSSQRKPLS 592
Query: 535 ------NTSKNAIRNKSMQQT--------YIRTLNDVKRLKYRRTSMKVSCNKEEVRQSR 580
N S K + T Y TLND++ LK R + K + N+ QS
Sbjct: 593 VDPKQENVSSTVETAKQAETTASSDSFRKYANTLNDLRHLKSSR-NRKATSNE---TQSS 648
Query: 581 VIETEERRVDQDIA-GEKD---------------LVIQTDQRNIKKQSTIFEGTKSLTLD 624
TE ++ ++++ KD +++ ++++ F+ ++ TLD
Sbjct: 649 SNSTETSKLSKNVSESGKDKSPHWHSHGGSITGKSIVEQASSPLERRMDAFDENRAFTLD 708
Query: 625 DISRIVATEKSRELIP--------------------------GTNKDFTASGDNVPTKKA 658
DI ++++ +++RE P GT K T ++ P +
Sbjct: 709 DIPKVISEQRNREHRPNAFRHMPSYTDPSYRKNSGAIYDKNDGTQKGLTPKSEDAPIR-- 766
Query: 659 TNSNIYYSELTSEQYYILQIIAFSLLNSEGFDMQQIKPPDFPHKMSN--NNGLWTKFKTI 716
Y S+L++ + + +A +L+ D + D +MS+ G W KF
Sbjct: 767 -----YLSDLSNLELLFTKHVAVLILHPLVRDYYSL---DELMEMSDLRKGGFWEKFGKA 818
Query: 717 MGG--XXXXXXXXXXVFGTPLEYLTSHCGVESDLGVG 751
G FG PLE L +S +G G
Sbjct: 819 FKGKDAEKKNVKKKGTFGVPLEILVERNNAQSTVGTG 855
>YDL240w_2 [TZ] KOG2710 Rho GTPase-activating protein
Length = 271
Score = 244 bits (624), Expect = 4e-64
Identities = 121/235 (51%), Positives = 161/235 (68%), Gaps = 1/235 (0%)
Query: 750 VGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKEN 809
VGP K++IPI++DELISSLRQ+DMSVEG+FRKNGNIRRL+ L ID+ P PD SKEN
Sbjct: 1 VGPVKIRIPIIIDELISSLRQMDMSVEGIFRKNGNIRRLRELTANIDSNPTEAPDFSKEN 60
Query: 810 VIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAE 869
IQLS LLKKF+RELP P+L+ LY WI A K+ + K+R + L+Y++LP Y RN+ E
Sbjct: 61 AIQLSALLKKFIRELPQPILSTDLYELWIKAAKIDLEDEKQRVILLIYSLLPTYNRNLLE 120
Query: 870 VIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSNFQTTTQAET-YVDX 928
+ SFL+W SSFS+++ GSKMDIHNLSTVI PN+LY +SN + E+ VD
Sbjct: 121 ALLSFLHWTSSFSYIENEMGSKMDIHNLSTVITPNILYLRHKEISNDNVPDEPESGLVDS 180
Query: 929 XXXXXXXXXXXXXXXXGYLITNNEKLSMVPKYLSDLLDQAEQQQINSLEDIRNFI 983
YLIT+NE+++MVPK+L +LL + Q++++ E I +FI
Sbjct: 181 FAQNKGENYFLAIEIVDYLITHNEEMAMVPKFLMNLLKDVQLQKLDNYESINHFI 235
>SPBC3F6.05_2 [TZ] KOG2710 Rho GTPase-activating protein
Length = 292
Score = 166 bits (419), Expect = 2e-40
Identities = 93/210 (44%), Positives = 130/210 (61%), Gaps = 21/210 (10%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDL 816
IP + ++++++ DMSV GVFRKNGNIRRLK L + +D P D +E IQL+ L
Sbjct: 3 IPAFIGNTLAAMKRKDMSVVGVFRKNGNIRRLKELSDMLDVSPDSI-DYEQETPIQLAAL 61
Query: 817 LKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFLY 876
LKKFLRELP+PLLTF L+ +I ++KL ++ + R L L +LP+ +R+ EVIF FLY
Sbjct: 62 LKKFLRELPDPLLTFKLFGLFITSSKLESEEERMRVLHLTICLLPKGHRDTMEVIFGFLY 121
Query: 877 WASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSNFQTTTQAETYVDXXXXXXXXX 936
W +SFSH+D GSKMDIHNL+TVI PN+LY ++++ + E+++
Sbjct: 122 WVASFSHIDDEVGSKMDIHNLATVITPNILYSKSNDPVD-------ESFL---------- 164
Query: 937 XXXXXXXXGYLITNNEKLSMVPKYLSDLLD 966
LI N EK VP+ +S LLD
Sbjct: 165 ---AIEAVHLLIENFEKFCEVPREISLLLD 191
>Hs21361591 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 444
Score = 87.8 bits (216), Expect = 8e-17
Identities = 50/154 (32%), Positives = 68/154 (43%), Gaps = 13/154 (8%)
Query: 45 CADCKKPIHSNALKALGSHYHENCLVCYDCG-AICKPKYFPYDLPDSKETVLLCQKHYFT 103
C C KPI + ALG +H VC C A+ +F K+ C + YF
Sbjct: 211 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFF------EKDGAPFCPECYFE 264
Query: 104 RNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNL-YCKYHFLK 162
R + C C +P+ G + +HFCC CGE DE FH + YC+ FL+
Sbjct: 265 RFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFG-DEGFHEREGRPYCRRDFLQ 323
Query: 163 YLSRRCEGCGYPISDQYIEFQKGDKMECWHTECY 196
+ RC+GC PI D YI WH +C+
Sbjct: 324 LFAPRCQGCQGPILDNYISALSA----LWHPDCF 353
Score = 62.8 bits (151), Expect = 3e-09
Identities = 34/120 (28%), Positives = 53/120 (43%), Gaps = 7/120 (5%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGA-ICKPKYFPYDLPDSKETVLLCQKHYF 102
+C C+ PI N + AL + +H +C VC +C A +F + E LC+ H+
Sbjct: 328 RCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEH------EGRPLCENHFH 381
Query: 103 TRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFLK 162
R LC+ C P++G + G+ + HF C+ C YC+ FLK
Sbjct: 382 ARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLK 441
Score = 56.6 bits (135), Expect = 2e-07
Identities = 32/137 (23%), Positives = 51/137 (36%), Gaps = 5/137 (3%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFT 103
+C C +PI + ALG+H+H C CG + F +E C++ +
Sbjct: 269 RCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGF-----HEREGRPYCRRDFLQ 323
Query: 104 RNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFLKY 163
C C+ P+ Y + L+ F C C F H C+ HF
Sbjct: 324 LFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHAR 383
Query: 164 LSRRCEGCGYPISDQYI 180
C CG P++ + +
Sbjct: 384 RGSLCATCGLPVTGRCV 400
>HsM7706250 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 444
Score = 86.7 bits (213), Expect = 2e-16
Identities = 50/154 (32%), Positives = 68/154 (43%), Gaps = 13/154 (8%)
Query: 45 CADCKKPIHSNALKALGSHYHENCLVCYDCG-AICKPKYFPYDLPDSKETVLLCQKHYFT 103
C C KPI + ALG +H VC C A+ +F K+ C + YF
Sbjct: 211 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFF------EKDGAPFCPECYFE 264
Query: 104 RNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNL-YCKYHFLK 162
R + C C +P+ G + +HFCC CGE DE FH + YC+ FL+
Sbjct: 265 RFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFG-DEGFHEREGRPYCRRDFLQ 323
Query: 163 YLSRRCEGCGYPISDQYIEFQKGDKMECWHTECY 196
+ RC+GC PI D YI WH +C+
Sbjct: 324 LFAPRCQGCQGPILDNYISALS----LLWHPDCF 353
Score = 57.0 bits (136), Expect = 1e-07
Identities = 33/120 (27%), Positives = 50/120 (41%), Gaps = 7/120 (5%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGA-ICKPKYFPYDLPDSKETVLLCQKHYF 102
+C C+ PI N + AL +H +C VC +C A +F + E LC+ H+
Sbjct: 328 RCQGCQGPILDNYISALSLLWHPDCFVCRECFAPFSGGSFFEH------EGRPLCENHFH 381
Query: 103 TRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFLK 162
R L C P++G + G+ + HF C+ C YC+ FLK
Sbjct: 382 ARRGSLWPTCGLPVTGRCVSALGRRFHPDHFACTFCLRPLTKGSFQERAGKPYCQPCFLK 441
Score = 52.0 bits (123), Expect = 5e-06
Identities = 31/137 (22%), Positives = 50/137 (35%), Gaps = 5/137 (3%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFT 103
+C C +PI + ALG+H+H C CG + F +E C++ +
Sbjct: 269 RCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGF-----HEREGRPYCRRDFLQ 323
Query: 104 RNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFLKY 163
C C+ P+ Y + L+ F C C F H C+ HF
Sbjct: 324 LFAPRCQGCQGPILDNYISALSLLWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHAR 383
Query: 164 LSRRCEGCGYPISDQYI 180
CG P++ + +
Sbjct: 384 RGSLWPTCGLPVTGRCV 400
>7291703 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 287
Score = 81.6 bits (200), Expect = 5e-15
Identities = 52/187 (27%), Positives = 82/187 (43%), Gaps = 13/187 (6%)
Query: 32 AVKSKSSPRPTRQ---CADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLP 88
AV S S+P P+ C C + I A+ +LG YH + C +CG + PK F + +
Sbjct: 90 AVASPSAPLPSMSASICCRCNEKIWPRAVCSLGKTYHPHHFTCKECGLVVDPKLF-FAVD 148
Query: 89 DSKETVLLCQKHYFTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECF 148
D ++C + Y ++ CS C+ P+ + + E+ F C C + F
Sbjct: 149 DD----VVCSECYLDKHAARCSACRTPILERGVAAAERKWHEKCFRCVSCSKSLVSASFF 204
Query: 149 HHYDNLYCKYHFLKYLSRRCEGCGYPISDQYIEFQKGDKMECWHTECYGIHKYWHVTISP 208
L+CK HF + S RC GC PI + + WH +C+ H + IS
Sbjct: 205 EVNGYLFCKAHFRELFSSRCAGCEKPIDRRAVVALSTK----WHAKCFKCH-HCRKRISA 259
Query: 209 EDFGLPN 215
+F + N
Sbjct: 260 REFWIEN 266
>Hs7662242 [T] KOG4270 GTPase-activator protein
Length = 818
Score = 78.6 bits (192), Expect = 5e-14
Identities = 57/194 (29%), Positives = 94/194 (48%), Gaps = 18/194 (9%)
Query: 731 FGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKL 790
FG PLE L + ++ PI + ++ L + M EG+FR + +LK
Sbjct: 253 FGKPLE---------EHLTISGREIAFPI--EACVTMLLECGMQEEGLFRVAPSASKLKK 301
Query: 791 LVEEIDNQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKE 850
L +D + S + ++ LK +LRELP PL+TF LY+ WI A+ + +Q +K
Sbjct: 302 LKAALDCCVVDVQEYSADPHA-IAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL 360
Query: 851 RALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREA 910
+AL LP+ N + FL S + V +KM N++ V+ PN+L+ +A
Sbjct: 361 QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDV-----NKMTPSNMAIVLGPNLLWPQA 415
Query: 911 D-NVSNFQTTTQAE 923
+ N++ TT +
Sbjct: 416 EGNITEMMTTVSLQ 429
>Hs4758670 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 386
Score = 77.4 bits (189), Expect = 1e-13
Identities = 46/158 (29%), Positives = 64/158 (40%), Gaps = 13/158 (8%)
Query: 41 PTRQCADCKKPIHSNALKALGSHYHENCLVCYDC-GAICKPKYFPYDLPDSKETVLLCQK 99
P CA C+KPI + ALG +H VC C I +F + + C
Sbjct: 148 PKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFF------ERSGLAYCPN 201
Query: 100 HYFTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNL-YCKY 158
Y + C+ C P+ + + +HF CS CGE E FH D YC+
Sbjct: 202 DYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGA-EGFHEKDKKPYCRK 260
Query: 159 HFLKYLSRRCEGCGYPISDQYIEFQKGDKMECWHTECY 196
FL S +C GC P+ + Y+ WH EC+
Sbjct: 261 DFLAMFSPKCGGCNRPVLENYLSAMD----TVWHPECF 294
Score = 62.8 bits (151), Expect = 3e-09
Identities = 33/119 (27%), Positives = 51/119 (42%), Gaps = 5/119 (4%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFT 103
+C C +P+ N L A+ + +H C VC DC F ++L C+ HY
Sbjct: 269 KCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSF-FELDGRP----FCELHYHH 323
Query: 104 RNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFLK 162
R LC C +P++G + G + +HF C+ C + D YC+ F K
Sbjct: 324 RRGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNK 382
Score = 57.0 bits (136), Expect = 1e-07
Identities = 36/152 (23%), Positives = 55/152 (35%), Gaps = 6/152 (3%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFT 103
+CA C PI L A+ +H C CG + + F K+ C+K +
Sbjct: 210 RCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGF-----HEKDKKPYCRKDFLA 264
Query: 104 RNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFLKY 163
+ C C P+ Y + ++ + F C C F +C+ H+
Sbjct: 265 MFSPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHR 324
Query: 164 LSRRCEGCGYPISDQYIEFQKGDKMECWHTEC 195
C GCG PI+ + I G K H C
Sbjct: 325 RGTLCHGCGQPITGRCIS-AMGYKFHPEHFVC 355
>Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 710
Score = 75.5 bits (184), Expect = 4e-13
Identities = 56/182 (30%), Positives = 96/182 (51%), Gaps = 14/182 (7%)
Query: 730 VFGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLK 789
+FG PL+ L +E+D V PS ++P+++ L+S L + + +EG+ R G+ R+K
Sbjct: 239 LFGVPLDSL-----LEADHKVLPST-QVPLVLQALLSCLEKRGLDMEGILRVPGSQARVK 292
Query: 790 LLVEEIDNQPQHCPDLSKENVIQ--LSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQK 847
L ++++ + S + V SDLLK+F+R+LP PLLT + + + K
Sbjct: 293 GLEQKLERD-FYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLK 351
Query: 848 RKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLY 907
++ + L LL +LP RN + + FL V +KM + N+STV+APN+
Sbjct: 352 QRLQVLHLLILILPEPNRNALKALLEFLR-----KVVAREQHNKMTLRNVSTVMAPNLFL 406
Query: 908 RE 909
+
Sbjct: 407 HQ 408
>Hs7382484 [TZ] KOG2710 Rho GTPase-activating protein
Length = 765
Score = 75.1 bits (183), Expect = 5e-13
Identities = 64/230 (27%), Positives = 105/230 (44%), Gaps = 28/230 (12%)
Query: 745 ESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPD 804
+ L + P ++P LVD L + + G+FR + +R++ L EE D D
Sbjct: 398 DKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGI----D 453
Query: 805 LSKE---NVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLP 861
+S E +V ++ LLK+FLR++P+PLLT LY +IN T L + + + L+LL +LP
Sbjct: 454 VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFIN-TLLLEPEEQLGTLQLLIYLLP 512
Query: 862 RYYRNVAEVIFSFLYWASSFSHVDGH--------SGSKMDIHNLSTVIAPNVLYREADNV 913
+ + FL + H D + +G+KM NL+T+ PN+L+++ +
Sbjct: 513 PCNCDTLHRLLQFLSIVA--RHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSD 570
Query: 914 SNFQTTTQAETYVDXXXXXXXXXXXXXXXXXGYLITNNEKLSMVPKYLSD 963
F + A +I N E L MVP L +
Sbjct: 571 KEFSVQSSAR----------AEESTAIIAVVQKMIENYEALFMVPPDLQN 610
>Hs7382482 [TZ] KOG2710 Rho GTPase-activating protein
Length = 974
Score = 75.1 bits (183), Expect = 5e-13
Identities = 64/230 (27%), Positives = 105/230 (44%), Gaps = 28/230 (12%)
Query: 745 ESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPD 804
+ L + P ++P LVD L + + G+FR + +R++ L EE D D
Sbjct: 398 DKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGI----D 453
Query: 805 LSKE---NVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLP 861
+S E +V ++ LLK+FLR++P+PLLT LY +IN T L + + + L+LL +LP
Sbjct: 454 VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFIN-TLLLEPEEQLGTLQLLIYLLP 512
Query: 862 RYYRNVAEVIFSFLYWASSFSHVDGH--------SGSKMDIHNLSTVIAPNVLYREADNV 913
+ + FL + H D + +G+KM NL+T+ PN+L+++ +
Sbjct: 513 PCNCDTLHRLLQFLSIVA--RHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSD 570
Query: 914 SNFQTTTQAETYVDXXXXXXXXXXXXXXXXXGYLITNNEKLSMVPKYLSD 963
F + A +I N E L MVP L +
Sbjct: 571 KEFSVQSSAR----------AEESTAIIAVVQKMIENYEALFMVPPDLQN 610
>Hs7382480 [TZ] KOG2710 Rho GTPase-activating protein
Length = 771
Score = 75.1 bits (183), Expect = 5e-13
Identities = 64/230 (27%), Positives = 105/230 (44%), Gaps = 28/230 (12%)
Query: 745 ESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPD 804
+ L + P ++P LVD L + + G+FR + +R++ L EE D D
Sbjct: 195 DKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGI----D 250
Query: 805 LSKE---NVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLP 861
+S E +V ++ LLK+FLR++P+PLLT LY +IN T L + + + L+LL +LP
Sbjct: 251 VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFIN-TLLLEPEEQLGTLQLLIYLLP 309
Query: 862 RYYRNVAEVIFSFLYWASSFSHVDGH--------SGSKMDIHNLSTVIAPNVLYREADNV 913
+ + FL + H D + +G+KM NL+T+ PN+L+++ +
Sbjct: 310 PCNCDTLHRLLQFLSIVA--RHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSD 367
Query: 914 SNFQTTTQAETYVDXXXXXXXXXXXXXXXXXGYLITNNEKLSMVPKYLSD 963
F + A +I N E L MVP L +
Sbjct: 368 KEFSVQSSAR----------AEESTAIIAVVQKMIENYEALFMVPPDLQN 407
>Hs7382478 [TZ] KOG2710 Rho GTPase-activating protein
Length = 562
Score = 75.1 bits (183), Expect = 5e-13
Identities = 64/230 (27%), Positives = 105/230 (44%), Gaps = 28/230 (12%)
Query: 745 ESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPD 804
+ L + P ++P LVD L + + G+FR + +R++ L EE D D
Sbjct: 195 DKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGI----D 250
Query: 805 LSKE---NVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLP 861
+S E +V ++ LLK+FLR++P+PLLT LY +IN T L + + + L+LL +LP
Sbjct: 251 VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFIN-TLLLEPEEQLGTLQLLIYLLP 309
Query: 862 RYYRNVAEVIFSFLYWASSFSHVDGH--------SGSKMDIHNLSTVIAPNVLYREADNV 913
+ + FL + H D + +G+KM NL+T+ PN+L+++ +
Sbjct: 310 PCNCDTLHRLLQFLSIVA--RHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSD 367
Query: 914 SNFQTTTQAETYVDXXXXXXXXXXXXXXXXXGYLITNNEKLSMVPKYLSD 963
F + A +I N E L MVP L +
Sbjct: 368 KEFSVQSSAR----------AEESTAIIAVVQKMIENYEALFMVPPDLQN 407
>Hs4502223 [TZ] KOG2710 Rho GTPase-activating protein
Length = 480
Score = 75.1 bits (183), Expect = 5e-13
Identities = 64/230 (27%), Positives = 105/230 (44%), Gaps = 28/230 (12%)
Query: 745 ESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPD 804
+ L + P ++P LVD L + + G+FR + +R++ L EE D D
Sbjct: 220 DKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGI----D 275
Query: 805 LSKE---NVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLP 861
+S E +V ++ LLK+FLR++P+PLLT LY +IN T L + + + L+LL +LP
Sbjct: 276 VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFIN-TLLLEPEEQLGTLQLLIYLLP 334
Query: 862 RYYRNVAEVIFSFLYWASSFSHVDGH--------SGSKMDIHNLSTVIAPNVLYREADNV 913
+ + FL + H D + +G+KM NL+T+ PN+L+++ +
Sbjct: 335 PCNCDTLHRLLQFLSIVA--RHADDNISKDGQEVTGNKMTSLNLATIFGPNLLHKQKSSD 392
Query: 914 SNFQTTTQAETYVDXXXXXXXXXXXXXXXXXGYLITNNEKLSMVPKYLSD 963
F + A +I N E L MVP L +
Sbjct: 393 KEFSVQSSAR----------AEESTAIIAVVQKMIENYEALFMVPPDLQN 432
>CE03768 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 444
Score = 75.1 bits (183), Expect = 5e-13
Identities = 62/202 (30%), Positives = 95/202 (46%), Gaps = 34/202 (16%)
Query: 731 FGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKL 790
FG PLE++ SHCG IP +VD+LI L +++EGVFRK+ NI +K
Sbjct: 247 FGVPLEFILSHCGGN-----------IPPIVDQLIEYLEAHALTMEGVFRKSANIGSIKR 295
Query: 791 LVEEI--------DNQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATK 842
L + I +N P++ D + S LLK F R L PL T LY ++
Sbjct: 296 LQDRINKGEKIDFENDPEY-KDNEYVASLHASVLLKTFFRSLGEPLTTNRLYPKLAALSE 354
Query: 843 LSDQKRKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIA 902
+S + K A++ +LPR + + + FL + S V + M +NLS V
Sbjct: 355 VS-KTEKSAAVKEFVKLLPRENYILLKTVIKFLTRVAENSKV-----NLMTANNLSVVFG 408
Query: 903 PNVLY--------READNVSNF 916
PN+ + + +N++NF
Sbjct: 409 PNLTWPTDQEVPISQLNNLNNF 430
>CE26357 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 1388
Score = 74.3 bits (181), Expect = 9e-13
Identities = 52/182 (28%), Positives = 85/182 (46%), Gaps = 15/182 (8%)
Query: 746 SDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDL 805
+D G + +P++V + + M G++R GN + L E + N+ DL
Sbjct: 734 ADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLSNRGFDSVDL 793
Query: 806 SK--------ENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLY 857
SK +V +S LLK FLR+LP PLLT LY +I+A ++S + L L
Sbjct: 794 SKVESLDPRWRDVNVVSSLLKMFLRKLPEPLLTDKLYPFFIDANRISTHHNRLHKLRNLL 853
Query: 858 TMLPRYYRNVAEVIFSFLYWASSFSHVDGHSG-SKMDIHNLSTVIAPNVLYREADNVSNF 916
LPR + + + L S + HS +KM+ NL+ + P+++ DN++
Sbjct: 854 RKLPRPHYDTLRFLIVHL------SEITKHSDVNKMECRNLALMFGPSIVRPSDDNMATM 907
Query: 917 QT 918
T
Sbjct: 908 VT 909
>Hs21264597 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1205
Score = 73.6 bits (179), Expect = 1e-12
Identities = 43/158 (27%), Positives = 81/158 (51%), Gaps = 8/158 (5%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEI--DNQPQHCPDLSKENVIQLS 814
IP++V + + Q ++ EG++RK G + + L+E + D + H + +++V +S
Sbjct: 725 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE-GEQHVDDVS 783
Query: 815 DLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSF 874
LK+FLR+LP+ L T + W+ A+++ D++ K L LP R + + S
Sbjct: 784 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 843
Query: 875 LYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADN 912
LY FS ++M++HNL+ V P + + +
Sbjct: 844 LYCVQCFSDT-----NQMNVHNLAIVFGPTLFQTDGQD 876
>Hs16975484 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1210
Score = 73.6 bits (179), Expect = 1e-12
Identities = 43/158 (27%), Positives = 81/158 (51%), Gaps = 8/158 (5%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEI--DNQPQHCPDLSKENVIQLS 814
IP++V + + Q ++ EG++RK G + + L+E + D + H + +++V +S
Sbjct: 730 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE-GEQHVDDVS 788
Query: 815 DLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSF 874
LK+FLR+LP+ L T + W+ A+++ D++ K L LP R + + S
Sbjct: 789 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 848
Query: 875 LYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADN 912
LY FS ++M++HNL+ V P + + +
Sbjct: 849 LYCVQCFSDT-----NQMNVHNLAIVFGPTLFQTDGQD 881
>Hs5902012_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1223
Score = 72.4 bits (176), Expect = 3e-12
Identities = 43/151 (28%), Positives = 83/151 (54%), Gaps = 8/151 (5%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDL 816
+P++V++LI+ + + EG++RK+G+ ++K L + +D + +L N+ ++ +
Sbjct: 750 VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESV-NLDDYNIHVIASV 808
Query: 817 LKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAE-VIFSFL 875
K++LR+LPNPL+TF LY ++ A L ++K R + + L R + N E +IF +
Sbjct: 809 FKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLV 868
Query: 876 YWASSFSHVDGHSGSKMDIHNLSTVIAPNVL 906
A ++M + L+ V AP +L
Sbjct: 869 RIALQ------EDTNRMSANALAIVFAPCIL 893
>CE23779_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 837
Score = 72.0 bits (175), Expect = 4e-12
Identities = 43/154 (27%), Positives = 84/154 (53%), Gaps = 6/154 (3%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQ-HCPDLSKENVIQLSD 815
+P L+D L ++ + VEGV+RK+G++ +++ + + I++ +L V L+
Sbjct: 511 VPTLLDRLFFAIETRALFVEGVYRKSGSLPQVRSIRKVIESTADADSVNLEDIGVHVLTT 570
Query: 816 LLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFL 875
L+K F REL P++ F LY +++N +++ D + R L ++ +LP+ R V + + L
Sbjct: 571 LVKAFFRELAEPIIIFDLYENFLNVSEVEDMGERVRCLSVMIELLPKPNRAVLDRLMYHL 630
Query: 876 YWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYRE 909
+ D + +KM +NL+ + P VL R+
Sbjct: 631 ARVA-----DQEAVNKMGCNNLALIFGPCVLRRQ 659
>Hs4757766 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 439
Score = 71.6 bits (174), Expect = 6e-12
Identities = 54/179 (30%), Positives = 91/179 (50%), Gaps = 20/179 (11%)
Query: 731 FGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKL 790
FG L++L P + IPI++ E ++ L+ ++ EG+FR++ N + ++
Sbjct: 242 FGVSLQHLQEK---------NPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVRE 292
Query: 791 LVEEIDNQPQHCP-DLSKENVIQL-SDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKR 848
+ ++ + P D + N + L + +LK FLRELP PLLTF LY H + + + +R
Sbjct: 293 VQQKYN---MGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQR 349
Query: 849 KERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLY 907
L++L T LP V + +FL S+ S +KM NL+ V PN+L+
Sbjct: 350 VPATLQVLQT-LPEENYQVLRFLTAFLVQISAHS-----DQNKMTNTNLAVVFGPNLLW 402
>Hs13775230 [T] KOG4270 GTPase-activator protein
Length = 655
Score = 71.6 bits (174), Expect = 6e-12
Identities = 48/151 (31%), Positives = 80/151 (52%), Gaps = 8/151 (5%)
Query: 758 PILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDLL 817
P+LV++ + +RQ + EG+FR G +K L + D + D S +V ++ LL
Sbjct: 60 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFD-SNTDVHTVASLL 118
Query: 818 KKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTM--LPRYYRNVAEVIFSFL 875
K +LRELP P++ ++ Y +++ KL ++ + EL + LP N+ + I FL
Sbjct: 119 KLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFL 178
Query: 876 YWASSFSHVDGHSGSKMDIHNLSTVIAPNVL 906
S+S V +KM + NL+TV PN+L
Sbjct: 179 DEVQSYSGV-----NKMSVQNLATVFGPNIL 204
>Hs7661858 [TZ] KOG2710 Rho GTPase-activating protein
Length = 1023
Score = 71.2 bits (173), Expect = 7e-12
Identities = 59/177 (33%), Positives = 90/177 (50%), Gaps = 18/177 (10%)
Query: 730 VFGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLK 789
+FG P L H V P IP + + +SL + EG+FRK+G++ RLK
Sbjct: 46 IFGVPFNALP-HSAV-------PEYGHIPSFLVDACTSLED-HIHTEGLFRKSGSVIRLK 96
Query: 790 LLVEEIDNQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRK 849
L ++D+ + C LS ++ LLK+F RELP P+L L+ + A +L ++ K
Sbjct: 97 ALKNKVDHG-EGC--LSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEE-K 152
Query: 850 ERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVL 906
+A LL +L + +V F+FL S S S +KMD NL+ + APN+L
Sbjct: 153 NKATLLLSCLLADHTVHVLRYFFNFLRNVSLRS-----SENKMDSSNLAVIFAPNLL 204
>CE27576 [TZ] KOG2710 Rho GTPase-activating protein
Length = 793
Score = 70.5 bits (171), Expect = 1e-11
Identities = 53/186 (28%), Positives = 96/186 (51%), Gaps = 18/186 (9%)
Query: 742 CGVESDLG-VGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQ 800
C +++++ V P L++P +V+ L ++ G+FR GN +R + L ++
Sbjct: 319 CSLDANIDDVDPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGG 378
Query: 801 HCPDLSKENVIQ------LSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALE 854
+ +N+++ ++ LLK++ R+LP LL Y+ +I A KL+ +R E A+
Sbjct: 379 GA--VINDNMVENTTSHDVATLLKEYFRDLPQSLLPGEHYSAYIGAAKLNVDERIE-AIR 435
Query: 855 LLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGH-------SGSKMDIHNLSTVIAPNVLY 907
LL+ +L + V+ FL+ S S D H SG+KMD NL+T+ AP++L
Sbjct: 436 LLFALLVSPILDTLFVLLKFLHEVSCHSQ-DRHDEDGELLSGNKMDARNLATIFAPSILR 494
Query: 908 READNV 913
+ D +
Sbjct: 495 VDHDKL 500
>CE11336 [TZ] KOG2710 Rho GTPase-activating protein
Length = 553
Score = 70.5 bits (171), Expect = 1e-11
Identities = 53/186 (28%), Positives = 96/186 (51%), Gaps = 18/186 (9%)
Query: 742 CGVESDLG-VGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQ 800
C +++++ V P L++P +V+ L ++ G+FR GN +R + L ++
Sbjct: 79 CSLDANIDDVDPHALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGG 138
Query: 801 HCPDLSKENVIQ------LSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALE 854
+ +N+++ ++ LLK++ R+LP LL Y+ +I A KL+ +R E A+
Sbjct: 139 GA--VINDNMVENTTSHDVATLLKEYFRDLPQSLLPGEHYSAYIGAAKLNVDERIE-AIR 195
Query: 855 LLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGH-------SGSKMDIHNLSTVIAPNVLY 907
LL+ +L + V+ FL+ S S D H SG+KMD NL+T+ AP++L
Sbjct: 196 LLFALLVSPILDTLFVLLKFLHEVSCHSQ-DRHDEDGELLSGNKMDARNLATIFAPSILR 254
Query: 908 READNV 913
+ D +
Sbjct: 255 VDHDKL 260
>CE01828 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 256
Score = 69.7 bits (169), Expect = 2e-11
Identities = 37/121 (30%), Positives = 55/121 (44%), Gaps = 14/121 (11%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFT 103
+C C +PI SN + ALG+H+H +C VC CG F LC++HY
Sbjct: 136 KCNGCSQPITSNFITALGTHWHPDCFVCQHCGVSFNGASF-----FEHNGAPLCERHYHE 190
Query: 104 RNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKC------KVDE---CFHHYDNL 154
+CS C+ ++G G+ + +HF CS C + +VD C Y+N
Sbjct: 191 SRGSICSQCRGAINGRCVAAMGRKFHPEHFRCSYCNHQLTKGTFKEVDRRPFCHKCYNNT 250
Query: 155 Y 155
Y
Sbjct: 251 Y 251
Score = 66.6 bits (161), Expect = 2e-10
Identities = 38/156 (24%), Positives = 61/156 (38%), Gaps = 9/156 (5%)
Query: 41 PTRQCADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKH 100
P CA C KPI + ALG +H C +CGA + F + C++
Sbjct: 15 PKGDCAACGKPIIGQVVIALGKMWHPEHYTCCECGAELGQRPF-----FERNGRAFCEED 69
Query: 101 YFTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHF 160
Y + + C C ++ + K + + F C+ C + D YCK F
Sbjct: 70 YHNQFSPKCQGCHRAITDRCVSVMNKNFHIECFTCAECNQPFGEDGFHEKNGQTYCKRDF 129
Query: 161 LKYLSRRCEGCGYPISDQYIEFQKGDKMECWHTECY 196
+ + +C GC PI+ +I WH +C+
Sbjct: 130 FRLFAPKCNGCSQPITSNFITALGTH----WHPDCF 161
>Hs21361736 [T] KOG4270 GTPase-activator protein
Length = 803
Score = 69.3 bits (168), Expect = 3e-11
Identities = 52/177 (29%), Positives = 78/177 (43%), Gaps = 17/177 (9%)
Query: 731 FGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKL 790
FGTPLE G E I + ++ + L + M EG+FR +LK
Sbjct: 250 FGTPLEEHLKRSGRE-----------IALPIEACVMLLLETGMKEEGLFRIGAGASKLKK 298
Query: 791 LVEEIDNQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKE 850
L +D H + + ++ LK +LRELP PL+TF+LY W + DQ +K
Sbjct: 299 LKAALDCSTSHLDEFYSDPHA-VAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKL 357
Query: 851 RALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLY 907
+ L LP + FL + S V +KM N++ V+APN+L+
Sbjct: 358 QDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDV-----NKMTPSNIAIVLAPNLLW 409
>7294614 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 476
Score = 69.3 bits (168), Expect = 3e-11
Identities = 53/185 (28%), Positives = 82/185 (43%), Gaps = 17/185 (9%)
Query: 731 FGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDM-SVEGVFRKNGNIRRLK 789
FG PL+++ + P IP +V + + SL + EG+FR++GN +
Sbjct: 274 FGVPLKFIVMN---------SPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSEIM 324
Query: 790 LLVEEIDNQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRK 849
L E ++ DL NV ++ LLK FLR+L PLLTF LY ++R
Sbjct: 325 ALKERVNRGED--VDLKSVNVHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLDWPKEERS 382
Query: 850 ERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYRE 909
+L+ LP + + I FL +D +KM NL+ V PN L+
Sbjct: 383 RNVTQLIREKLPEENYELFKYIVEFLVRV-----MDCEDLNKMTSSNLAIVFGPNFLWSR 437
Query: 910 ADNVS 914
+ + S
Sbjct: 438 STSTS 442
>CE06642 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 634
Score = 68.2 bits (165), Expect = 6e-11
Identities = 54/218 (24%), Positives = 96/218 (43%), Gaps = 34/218 (15%)
Query: 712 KFKTIMGGXXXXXXXXXXVFGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQL 771
+ + + G +FG PL+ L H IP+++++ I L++
Sbjct: 158 RIQQVCGQAAKLVDRRTSIFGVPLKGLLEH-----------QNRHIPLIIEKSIDQLQRR 206
Query: 772 DMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPD-----LSKENVIQLSDLLKKFLRELPN 826
+ +G++R G +K +EEI N + L EN + L+ ++K +LR+LP
Sbjct: 207 GLRAKGIYRTCG----VKSKIEEICNAFERSSSDDEVCLDNENPMNLASVVKLYLRKLPE 262
Query: 827 PLLTFSLYNHWI---------NATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFLYW 877
PLLTF LY+ ++ A+ + ++ + L L LP + + I L
Sbjct: 263 PLLTFELYDDFVRLGTECCSAQASGSNCEEERVEQLRQLARKLPVHNYETLKFIMLHLNR 322
Query: 878 ASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSN 915
S F H + M NLSTVIAP++++ + +
Sbjct: 323 VSWF-----HEVNLMSTSNLSTVIAPSLIWMSPKRIDH 355
>CE06641 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 863
Score = 68.2 bits (165), Expect = 6e-11
Identities = 54/218 (24%), Positives = 96/218 (43%), Gaps = 34/218 (15%)
Query: 712 KFKTIMGGXXXXXXXXXXVFGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQL 771
+ + + G +FG PL+ L H IP+++++ I L++
Sbjct: 387 RIQQVCGQAAKLVDRRTSIFGVPLKGLLEH-----------QNRHIPLIIEKSIDQLQRR 435
Query: 772 DMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPD-----LSKENVIQLSDLLKKFLRELPN 826
+ +G++R G +K +EEI N + L EN + L+ ++K +LR+LP
Sbjct: 436 GLRAKGIYRTCG----VKSKIEEICNAFERSSSDDEVCLDNENPMNLASVVKLYLRKLPE 491
Query: 827 PLLTFSLYNHWI---------NATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFLYW 877
PLLTF LY+ ++ A+ + ++ + L L LP + + I L
Sbjct: 492 PLLTFELYDDFVRLGTECCSAQASGSNCEEERVEQLRQLARKLPVHNYETLKFIMLHLNR 551
Query: 878 ASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSN 915
S F H + M NLSTVIAP++++ + +
Sbjct: 552 VSWF-----HEVNLMSTSNLSTVIAPSLIWMSPKRIDH 584
>Hs21314774 [T] KOG4724 Predicted Rho GTPase-activating protein
Length = 731
Score = 67.8 bits (164), Expect = 8e-11
Identities = 47/161 (29%), Positives = 83/161 (51%), Gaps = 7/161 (4%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDL 816
+P + ++++ L S EG+FR+ N + K L EE+++ DL + V L+ +
Sbjct: 100 LPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGD--AVDLERLPVHLLAVV 157
Query: 817 LKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFLY 876
K FLR +P LL+ L+ W+ A ++ D++ + AL+ + LPR + + + L+
Sbjct: 158 FKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLH 217
Query: 877 WASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSNFQ 917
S S V ++MD NL+ I PN+L E D +F+
Sbjct: 218 LISKNSEV-----NRMDSSNLAICIGPNMLTLENDQSLSFE 253
>Hs20270373 [T] KOG4724 Predicted Rho GTPase-activating protein
Length = 266
Score = 67.8 bits (164), Expect = 8e-11
Identities = 47/161 (29%), Positives = 83/161 (51%), Gaps = 7/161 (4%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDL 816
+P + ++++ L S EG+FR+ N + K L EE+++ DL + V L+ +
Sbjct: 100 LPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGD--AVDLERLPVHLLAVV 157
Query: 817 LKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFLY 876
K FLR +P LL+ L+ W+ A ++ D++ + AL+ + LPR + + + L+
Sbjct: 158 FKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLH 217
Query: 877 WASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSNFQ 917
S S V ++MD NL+ I PN+L E D +F+
Sbjct: 218 LISKNSEV-----NRMDSSNLAICIGPNMLTLENDQSLSFE 253
>Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 618
Score = 67.8 bits (164), Expect = 8e-11
Identities = 46/153 (30%), Positives = 81/153 (52%), Gaps = 8/153 (5%)
Query: 755 LKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQ-- 812
++IP++ +LIS + + + EG+ R G R+K L +E++ + + E+V Q
Sbjct: 295 MRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYE-GTFNWESVKQHD 353
Query: 813 LSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIF 872
+ LLK F+RELP PLL+ + L +K++ +AL LL +LP R+ + +
Sbjct: 354 AASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALL 413
Query: 873 SFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNV 905
FL +D +KM + N++ V+APN+
Sbjct: 414 EFLQRV-----IDNKEKNKMTVMNVAMVMAPNL 441
>SPBC28E12.03_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 804
Score = 67.8 bits (164), Expect = 8e-11
Identities = 41/158 (25%), Positives = 81/158 (50%), Gaps = 8/158 (5%)
Query: 755 LKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLS 814
L++P L+ I+ + M EG++RK+G ++K +V + N+ E++ ++
Sbjct: 629 LRVPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVLDP--SEDISAVT 686
Query: 815 DLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSF 874
+ K++LR LPNP++T+ Y +I A + + K ++ LP + + ++I
Sbjct: 687 SVFKQYLRNLPNPIITYDQYFPFITAANCASFQDKLDGFIMVIKSLPPAHAEILQLIIRH 746
Query: 875 LYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADN 912
L +++SH ++M NL+ V +P L R+ DN
Sbjct: 747 LARVAAYSH-----ANRMTSKNLAVVFSP-TLIRDPDN 778
>Hs22065906 [T] KOG4724 Predicted Rho GTPase-activating protein
Length = 975
Score = 67.0 bits (162), Expect = 1e-10
Identities = 39/157 (24%), Positives = 83/157 (52%), Gaps = 9/157 (5%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDL 816
+P V +++ L Q +G+FR++ N++ + L E++++ + L E++ ++ +
Sbjct: 160 LPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVE--VHLDCESIFVIASV 217
Query: 817 LKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFLY 876
LK FLR +P + + LY+HW++ + + K ++ L LPR + +F L+
Sbjct: 218 LKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRYLFGVLH 277
Query: 877 WASSFSHVDGHSGS-KMDIHNLSTVIAPNVLYREADN 912
+++ HS S +M NL+ +AP++L+ A +
Sbjct: 278 ------NIEQHSSSNQMTAFNLAVCVAPSILWPPASS 308
>Hs21361124 [TZR] KOG1704 FOG: LIM domain
Length = 279
Score = 67.0 bits (162), Expect = 1e-10
Identities = 48/168 (28%), Positives = 72/168 (42%), Gaps = 25/168 (14%)
Query: 44 QCADCKKPIHSNALKA--LGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHY 101
+C +CKK I K GS +HE C +C+ C K F +P K+ C Y
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSF---IP--KDNQNFCVPCY 154
Query: 102 FTRNNLLCSVCKEPLSGIYFNTFGKLYDEQH-----FCCSLCGEKCKVDECFHHYDNLYC 156
++ + C CK+P++ T G Y EQ F C+ C ++ D YC
Sbjct: 155 EKQHAMQCVQCKKPIT-----TGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYC 209
Query: 157 KYHFLKYLSRRCEGCGYPIS----DQYIEFQKGDKMECWHTECYGIHK 200
F +++C GC PIS +YI F++ WH +C+ K
Sbjct: 210 LNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQ----WHNDCFNCKK 253
>Hs4506345 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 557
Score = 66.2 bits (160), Expect = 2e-10
Identities = 34/120 (28%), Positives = 53/120 (43%), Gaps = 7/120 (5%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGA-ICKPKYFPYDLPDSKETVLLCQKHYF 102
+C C + I N + AL + +H C VC +C +F +D C+ HY
Sbjct: 441 KCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQP------YCEVHYH 494
Query: 103 TRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFLK 162
R LCS C++P++G K + +HF C+ C ++ D YC+ FLK
Sbjct: 495 ERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLK 554
Score = 65.1 bits (157), Expect = 5e-10
Identities = 40/153 (26%), Positives = 59/153 (38%), Gaps = 11/153 (7%)
Query: 45 CADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFTR 104
C CKKPI + A+G +H VC C + F ++ C+K Y
Sbjct: 324 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNF-----FERDGQPYCEKDYHNL 378
Query: 105 NNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYD-NLYCKYHFLKY 163
+ C C P+ + + +HF C+ CG E FH D YC+ +
Sbjct: 379 FSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFG-PEGFHEKDGKAYCRKDYFDM 437
Query: 164 LSRRCEGCGYPISDQYIEFQKGDKMECWHTECY 196
+ +C GC I + YI WH EC+
Sbjct: 438 FAPKCGGCARAILENYISALN----TLWHPECF 466
Score = 59.3 bits (142), Expect = 3e-08
Identities = 36/137 (26%), Positives = 51/137 (36%), Gaps = 5/137 (3%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFT 103
+C C PI + AL +H C CGA P+ F K+ C+K YF
Sbjct: 382 RCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGF-----HEKDGKAYCRKDYFD 436
Query: 104 RNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFLKY 163
C C + Y + L+ + F C C F H YC+ H+ +
Sbjct: 437 MFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHER 496
Query: 164 LSRRCEGCGYPISDQYI 180
C GC PI+ + I
Sbjct: 497 RGSLCSGCQKPITGRCI 513
Score = 51.2 bits (121), Expect = 8e-06
Identities = 31/117 (26%), Positives = 47/117 (39%), Gaps = 5/117 (4%)
Query: 108 LCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFLKYLSRR 167
+C CK+P++G GK + +HF C+ C E+ F YC+ + S R
Sbjct: 323 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 382
Query: 168 CEGCGYPISDQYIEFQKGDKMECWHTECYGIHKYWHVTISPEDFGLPNLKVYRIEEY 224
C C PI D+ + WH E + PE F + K Y ++Y
Sbjct: 383 CYYCNGPILDKVVTALD----RTWHPEHF-FCAQCGAFFGPEGFHEKDGKAYCRKDY 434
>7304324 [TZ] KOG2710 Rho GTPase-activating protein
Length = 205
Score = 66.2 bits (160), Expect = 2e-10
Identities = 52/168 (30%), Positives = 83/168 (48%), Gaps = 27/168 (16%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQ------PQHCPDLSKENV 810
+PI V+ I L + G+FR + + +R+K L EE D CP
Sbjct: 2 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPH------ 55
Query: 811 IQLSDLLKKFLRELPNPLLTFSLYNHWINATK---LSDQKRKERALELLYTMLPRYYRNV 867
++ LLK+FLR+LP PLL +LY ++ + + +++ + A+ L +LP +R+
Sbjct: 56 -DVATLLKEFLRDLPEPLLCNTLYLTFLKTQRMYCIRNRRLQLEAISHLIRLLPIPHRDT 114
Query: 868 AEVIFSFLYWASSFSHVDG---------HSGSKMDIHNLSTVIAPNVL 906
V+ FL A +H D G+KMD +NL+TV APN+L
Sbjct: 115 LYVLLVFL--AKVAAHSDDIWSTEGCCLTLGNKMDSYNLATVFAPNIL 160
>HsM4503723 [TZR] KOG1704 FOG: LIM domain
Length = 279
Score = 65.9 bits (159), Expect = 3e-10
Identities = 48/168 (28%), Positives = 71/168 (41%), Gaps = 25/168 (14%)
Query: 44 QCADCKKPIHSNALKA--LGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHY 101
+C +CKK I K GS +HE C +C+ C K F +P K+ C Y
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSF---IP--KDNQNFCVPCY 154
Query: 102 FTRNNLLCSVCKEPLSGIYFNTFGKLYDEQH-----FCCSLCGEKCKVDECFHHYDNLYC 156
++ + C CK P++ T G Y EQ F C+ C ++ D YC
Sbjct: 155 EKQHAMQCVQCKMPIT-----TGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYC 209
Query: 157 KYHFLKYLSRRCEGCGYPIS----DQYIEFQKGDKMECWHTECYGIHK 200
F +++C GC PIS +YI F++ WH +C+ K
Sbjct: 210 LNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQ----WHNDCFNCKK 253
>7299033 [TZ] KOG2272 Focal adhesion protein PINCH-1 contains LIM domains
Length = 335
Score = 65.9 bits (159), Expect = 3e-10
Identities = 34/108 (31%), Positives = 45/108 (41%), Gaps = 5/108 (4%)
Query: 45 CADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFTR 104
C C++PI + ALG H+H VC C K F K + C+ HY
Sbjct: 201 CGACRRPIEERVVTALGKHWHVEHFVCAKC-----EKPFLGHRHYEKRGLAYCETHYHQL 255
Query: 105 NNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYD 152
LC VC + + G F K + HF CS+C K F+ YD
Sbjct: 256 FGNLCFVCNQVIGGDVFTALNKAWCVHHFACSVCDTKMTQKSKFYEYD 303
>HsM19923515 [T] KOG4270 GTPase-activator protein
Length = 726
Score = 65.5 bits (158), Expect = 4e-10
Identities = 50/177 (28%), Positives = 76/177 (42%), Gaps = 17/177 (9%)
Query: 731 FGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKL 790
FGTPL G E I + ++ + L + M EG+FR +LK
Sbjct: 173 FGTPLAEHLKRSGRE-----------IALPIEACVMLLLETGMKEEGLFRIGAGASKLKK 221
Query: 791 LVEEIDNQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKE 850
L +D H + + ++ LK +LRELP PL+TF+LY W + DQ +K
Sbjct: 222 LKAALDCSTSHLDEFYSDPHA-VAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKL 280
Query: 851 RALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLY 907
+ L LP + FL + S V +KM N++ V+ PN+L+
Sbjct: 281 QDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDV-----NKMTPSNIAIVLGPNLLW 332
>7298768 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 328
Score = 64.7 bits (156), Expect = 7e-10
Identities = 47/186 (25%), Positives = 75/186 (40%), Gaps = 35/186 (18%)
Query: 44 QCADCKKPIHSNALKALGSHYHENC-----LVCYDC------------GAICKPKYFPYD 86
+CA C+KPI +A+ A+ +H +C +VC+ C G P++F
Sbjct: 125 RCAKCEKPITDSAVLAMNVKWHRDCFRCNNIVCHKCQEAITKRMITALGKTWHPEHFLCH 184
Query: 87 LPDSKETVL-----------LCQKHYFTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCC 135
D E +L +C K + R C+ CK+P+ G+ + E FCC
Sbjct: 185 HCD--EQILDATFNVQSGEPVCNKCFVERYTYTCAGCKKPILEKTICAMGERWHEACFCC 242
Query: 136 SLCGEKCKVDECFHHYDNL-YCKYHFLKYLSRRCEGCGYPISDQYIEFQKGDKMECWHTE 194
+K + F+ D YCK + + RC C PI+D + WH
Sbjct: 243 GGACKKPLASQTFYERDGKPYCKQDYENLFAARCAKCEKPITDSAVLAMNVK----WHRN 298
Query: 195 CYGIHK 200
C+ +K
Sbjct: 299 CFQCNK 304
Score = 61.2 bits (147), Expect = 8e-09
Identities = 40/153 (26%), Positives = 62/153 (40%), Gaps = 10/153 (6%)
Query: 45 CADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFTR 104
C C++ I + ALG +H +C+ C F S E V C K + R
Sbjct: 7 CHKCQEAITKRMITALGKTWHPEHFLCHHCDEQILDATFNVQ---SGEPV--CNKCFVER 61
Query: 105 NNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNL-YCKYHFLKY 163
C+ CK+P+ G+ + E FCC +K ++ F+ D YCK +
Sbjct: 62 YTYTCAGCKKPILEKTICAMGESWHEDCFCCGGACKKPLANQTFYERDGKPYCKKDYEDL 121
Query: 164 LSRRCEGCGYPISDQYIEFQKGDKMECWHTECY 196
+ RC C PI+D + WH +C+
Sbjct: 122 FAARCAKCEKPITDSAVLAMNVK----WHRDCF 150
>7298573 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 497
Score = 64.7 bits (156), Expect = 7e-10
Identities = 37/153 (24%), Positives = 61/153 (39%), Gaps = 11/153 (7%)
Query: 45 CADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFTR 104
C C+KPI + ALG +H C C + F ++ C+ Y
Sbjct: 322 CNACEKPIVGQVITALGKTWHPEHFTCNHCSQELGTRNF-----FERDGFPYCEPDYHNL 376
Query: 105 NNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNL-YCKYHFLKY 163
+ C+ C + K + +HF C+ CG++ +E FH D YC+ + +
Sbjct: 377 FSPRCAYCNGAILDKCVTALDKTWHTEHFFCAQCGQQFG-EEGFHERDGKPYCRNDYFEM 435
Query: 164 LSRRCEGCGYPISDQYIEFQKGDKMECWHTECY 196
+ +C GC I + YI WH +C+
Sbjct: 436 FAPKCNGCNRAIMENYISALNSQ----WHPDCF 464
>Hs22050706 [T] KOG4271 Rho-GTPase activating protein
Length = 1499
Score = 64.3 bits (155), Expect = 9e-10
Identities = 48/197 (24%), Positives = 95/197 (47%), Gaps = 10/197 (5%)
Query: 733 TPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLV 792
T + +++ GV V P K IPI ++ I + +S EG++R +GN ++ L
Sbjct: 1238 TKATWESNYFGVPLTTVVTPEK-PIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQ 1296
Query: 793 EEIDNQPQHCPDLSKEN--VIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKE 850
+ D H DL++++ V ++ +K F ELP+PL+ +++ + A K++D+++K
Sbjct: 1297 RQFDQD--HNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKL 1354
Query: 851 RALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREA 910
AL+ + P+ V + + S L + SH + + M NLS P ++ +
Sbjct: 1355 HALKEVLKKFPKENHEVFKYVISHL---NKVSH--NNKVNLMTSENLSICFWPTLMRPDF 1409
Query: 911 DNVSNFQTTTQAETYVD 927
+ T +T ++
Sbjct: 1410 STMDALTATRTYQTIIE 1426
>7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 1817
Score = 64.3 bits (155), Expect = 9e-10
Identities = 47/143 (32%), Positives = 76/143 (52%), Gaps = 23/143 (16%)
Query: 775 VEGVFRKNG---NIRRLKLLVEEIDNQPQHCPDLS----KENVIQLSDLLKKFLRELPNP 827
++G++R +G NI+RL+ +E + PDL K+++ +S LLK + RELPNP
Sbjct: 454 IDGIYRLSGITSNIQRLRRAFDE-----ERVPDLGNPEMKQDIHAVSSLLKMYFRELPNP 508
Query: 828 LLTFSLYNHWINATKLSDQKRKERALELLYTML---PRYYRNVAEVIFSFLYWASSFSHV 884
L T+ LY++++ A ++ + ER + T+L P +YR + Y A V
Sbjct: 509 LCTYQLYDNFVEAIQVKADEADERLRLMKETVLKLPPPHYRTLK-------YLAEHLYKV 561
Query: 885 DGHSG-SKMDIHNLSTVIAPNVL 906
H G + M NL+ V APN+L
Sbjct: 562 SQHHGRTGMTDKNLAIVWAPNLL 584
>Hs11641401 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 859
Score = 63.9 bits (154), Expect = 1e-09
Identities = 52/195 (26%), Positives = 89/195 (44%), Gaps = 9/195 (4%)
Query: 733 TPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLV 792
TP + T GV+ + + K+P +V + + + + + G++R +G ++ L
Sbjct: 636 TPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALK 695
Query: 793 EEID-NQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKER 851
D N LS ++ ++ LK + RELP PLLT LY ++ LSD KE
Sbjct: 696 AVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN 755
Query: 852 ALELLYTMLPRYYRNVAEVIFSFLYWASSFSHV-DGHSGSKMDIHNLSTVIAPNVLYREA 910
+ L LP + +FL+ V + +KM +HNL+TV P +L R +
Sbjct: 756 CMMHLLRSLP------DPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLL-RPS 808
Query: 911 DNVSNFQTTTQAETY 925
+ S T+ A+ +
Sbjct: 809 EVESKAHLTSAADIW 823
>Hs22045949 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 1444
Score = 63.5 bits (153), Expect = 2e-09
Identities = 44/137 (32%), Positives = 73/137 (53%), Gaps = 13/137 (9%)
Query: 775 VEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQ----LSDLLKKFLRELPNPLLT 830
V+G++R +G ++ L +E + CPDL++E +Q + L K + RELPNPLLT
Sbjct: 51 VDGIYRLSGVTSNIQRLRQEFGSD--QCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLT 108
Query: 831 FSLYNHWINA-TKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSG 889
+ LY + A + ++ + R ++ + P +YR + E + L +SFS S
Sbjct: 109 YELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTL-EYLIRHLAHIASFS-----SK 162
Query: 890 SKMDIHNLSTVIAPNVL 906
+ M NL+ V APN+L
Sbjct: 163 TNMHARNLALVWAPNLL 179
>Hs20536040 [T] KOG4270 GTPase-activator protein
Length = 364
Score = 62.4 bits (150), Expect = 3e-09
Identities = 45/152 (29%), Positives = 80/152 (52%), Gaps = 8/152 (5%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKE-NVIQLSD 815
IP +V ++ L Q ++ EG+FR NGN++ ++ L + ++ +L K+ +V +
Sbjct: 68 IPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVP--VELGKDGDVCSAAS 125
Query: 816 LLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFL 875
LLK FLRELP+ L+T +L +I + +E +L L LP + + + + FL
Sbjct: 126 LLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFL 185
Query: 876 YWASSFSHVDGHSGSKMDIHNLSTVIAPNVLY 907
+ H ++M++HNL+TV PN +
Sbjct: 186 TKVAKH-----HVQNRMNVHNLATVFGPNCFH 212
>Hs4758750_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 878
Score = 62.4 bits (150), Expect = 3e-09
Identities = 43/166 (25%), Positives = 82/166 (48%), Gaps = 7/166 (4%)
Query: 741 HCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQ 800
H GV D + K +PI++++L+ + + EG++RK+G R + L + + P
Sbjct: 553 HFGVCVD-SLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPA 611
Query: 801 HCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTML 860
L + ++ +LK++LRELP PL+TF+ Y ++ A +L +++ + A+ + L
Sbjct: 612 -AVKLENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHL 670
Query: 861 PRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVL 906
P N E + L + V ++M L+ + AP +L
Sbjct: 671 PEANHNSLERLIFHLVKVALLEDV-----NRMSPGALAIIFAPCLL 711
>Hs15147252 [T] KOG4270 GTPase-activator protein
Length = 621
Score = 61.6 bits (148), Expect = 6e-09
Identities = 41/152 (26%), Positives = 73/152 (47%), Gaps = 6/152 (3%)
Query: 756 KIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSD 815
+I + ++ + L M EG+FR LK L + + + P + + ++
Sbjct: 208 EIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHA-VAG 266
Query: 816 LLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFL 875
LK +LRELP PL+TF LY+ W+ A L + + +AL+ + + LP + + FL
Sbjct: 267 ALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFL 326
Query: 876 YWASSFSHVDGHSGSKMDIHNLSTVIAPNVLY 907
+ V +KM N++ V+ PN+L+
Sbjct: 327 ARLAEEQEV-----NKMTPSNIAIVLGPNLLW 353
>Hs11038641 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1227
Score = 61.6 bits (148), Expect = 6e-09
Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 8/175 (4%)
Query: 734 PLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVE 793
P T GV+ + + K+P +V + + + + M G++R +G ++ L
Sbjct: 1000 PSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKA 1059
Query: 794 EID-NQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERA 852
D N +S+ +V ++ LK + RELP PL T Y ++ LSD KE
Sbjct: 1060 AFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESC 1119
Query: 853 LELLYTMLPRYYRNVAEVIFSFLYWASSFSHV-DGHSGSKMDIHNLSTVIAPNVL 906
+ L LP + +FL+ V + + +KM +HNL+TV P +L
Sbjct: 1120 MLNLLLSLPE------ANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLL 1168
>Hs11038639 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1271
Score = 61.6 bits (148), Expect = 6e-09
Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 8/175 (4%)
Query: 734 PLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVE 793
P T GV+ + + K+P +V + + + + M G++R +G ++ L
Sbjct: 1044 PSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKA 1103
Query: 794 EID-NQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERA 852
D N +S+ +V ++ LK + RELP PL T Y ++ LSD KE
Sbjct: 1104 AFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESC 1163
Query: 853 LELLYTMLPRYYRNVAEVIFSFLYWASSFSHV-DGHSGSKMDIHNLSTVIAPNVL 906
+ L LP + +FL+ V + + +KM +HNL+TV P +L
Sbjct: 1164 MLNLLLSLPE------ANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLL 1212
>CE00918 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 837
Score = 61.2 bits (147), Expect = 8e-09
Identities = 47/189 (24%), Positives = 88/189 (45%), Gaps = 18/189 (9%)
Query: 730 VFGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLK 789
VFG+ L + H E+ L +P + + + + +G++R +GN+ ++
Sbjct: 607 VFGSTLSAICQH---ENSL--------VPKFIRVITEVIESKGLETDGIYRVSGNLSAVQ 655
Query: 790 LLVEEIDNQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRK 849
+ + D Q + +S+E++ L+ LK F REL +PL SL+ + +A ++ + +
Sbjct: 656 KIRCQAD-QDNYKALVSEEDIHVLTGALKLFFRELTDPLFPISLHKEYTSAMQMPNATTR 714
Query: 850 ERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYRE 909
+ E L + LP R +++ L +S S S ++M HNL+ V P L+
Sbjct: 715 FKKFEELLSRLPNENRETLKMLLRHLNRVASHS-----SQNRMQQHNLAIVFGP-TLFHN 768
Query: 910 ADNVSNFQT 918
D N T
Sbjct: 769 GDGAVNLAT 777
>HsM16975482 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1704
Score = 60.8 bits (146), Expect = 1e-08
Identities = 43/179 (24%), Positives = 78/179 (43%), Gaps = 14/179 (7%)
Query: 733 TPLEYLTSHCGVESDLGVGPSKLK--------IPILVDELISSLRQLDMSVEGVFRKNGN 784
T L++ H +E G + L+ +PI+V+ I+ + Q + + +++KNG+
Sbjct: 1096 TKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGD 1155
Query: 785 IRRLKLLVEEIDNQPQHCP-DLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKL 843
+ L+E + K + ++ +LK FL ++ + LLT LY +WI+A
Sbjct: 1156 PLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDT 1215
Query: 844 SDQKRKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIA 902
D K + + LP R I LY S + + M+ HNL+ V +
Sbjct: 1216 QDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEI-----NHMNAHNLALVFS 1269
>Hs7657307 [T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM
proteins
Length = 676
Score = 60.8 bits (146), Expect = 1e-08
Identities = 52/211 (24%), Positives = 82/211 (38%), Gaps = 22/211 (10%)
Query: 3 RPTIARPHLYNGQLPNTEEVLPNRTESYMAVKSKSSPRPTRQCADCKKPIHS--NALKAL 60
+P + P L E L R E M K+ C C K + A +A+
Sbjct: 432 QPLVPGPELRPSAAELKLEALTQRLEREMDAHPKADYFGA--CVKCSKGVFGAGQACQAM 489
Query: 61 GSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHY----FTRNNLLCSVCKEPL 116
G+ YH+ C C C + K F + + C++ + F ++ C +C +
Sbjct: 490 GNLYHDTCFTCAACSRKLRGKAFYF-----VNGKVFCEEDFLYSGFQQSADRCFLCGHLI 544
Query: 117 SGIYFNTFGKLYDEQHFCCSLCGEKCK-VDECFHHYDNLYCKYHFLKYLSRRCEGCGYPI 175
+ GK Y F C +C E V + +YC + K L+ +C CG PI
Sbjct: 545 MDMILQALGKSYHPGCFRCVICNECLDGVPFTVDSENKIYCVRDYHKVLAPKCAACGLPI 604
Query: 176 -----SDQYIEFQKGDK---MECWHTECYGI 198
SD+ I D+ +EC+H E G+
Sbjct: 605 LPPEGSDETIRVVSMDRDYHVECYHCEDCGL 635
>Hs21264594 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 876
Score = 60.8 bits (146), Expect = 1e-08
Identities = 43/179 (24%), Positives = 78/179 (43%), Gaps = 14/179 (7%)
Query: 733 TPLEYLTSHCGVESDLGVGPSKLK--------IPILVDELISSLRQLDMSVEGVFRKNGN 784
T L++ H +E G + L+ +PI+V+ I+ + Q + + +++KNG+
Sbjct: 268 TKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGD 327
Query: 785 IRRLKLLVEEIDNQPQHCP-DLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKL 843
+ L+E + K + ++ +LK FL ++ + LLT LY +WI+A
Sbjct: 328 PLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDT 387
Query: 844 SDQKRKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIA 902
D K + + LP R I LY S + + M+ HNL+ V +
Sbjct: 388 QDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEI-----NHMNAHNLALVFS 441
>Hs21264592 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1704
Score = 60.8 bits (146), Expect = 1e-08
Identities = 43/179 (24%), Positives = 78/179 (43%), Gaps = 14/179 (7%)
Query: 733 TPLEYLTSHCGVESDLGVGPSKLK--------IPILVDELISSLRQLDMSVEGVFRKNGN 784
T L++ H +E G + L+ +PI+V+ I+ + Q + + +++KNG+
Sbjct: 1096 TKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGD 1155
Query: 785 IRRLKLLVEEIDNQPQHCP-DLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKL 843
+ L+E + K + ++ +LK FL ++ + LLT LY +WI+A
Sbjct: 1156 PLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDT 1215
Query: 844 SDQKRKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIA 902
D K + + LP R I LY S + + M+ HNL+ V +
Sbjct: 1216 QDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEI-----NHMNAHNLALVFS 1269
>SPAC29A4.11_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 841
Score = 60.8 bits (146), Expect = 1e-08
Identities = 45/170 (26%), Positives = 87/170 (50%), Gaps = 11/170 (6%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDL 816
+P ++ +S + + VEG++R +G+ ++++LV+E +N L+ + + + +
Sbjct: 665 LPQVIAMCVSCVDAHGLEVEGIYRISGSASQVRVLVDEFENGSIRMEHLTSD-LFACTSV 723
Query: 817 LKKFLRELPNPLLTFSLYNHWINATKLSDQKRK-ERALELLYTMLPRYYRNVAEVIFSFL 875
LK +L LP P++ + Y + A K+ ++ K ER +E++ T+ P + +F FL
Sbjct: 724 LKTYLHRLPEPVIPGTQYEELLEAEKIEKEEEKIERVVEVMKTLHPAHLS-----VFRFL 778
Query: 876 YWASSFSHVDGHSGSK-MDIHNLSTVIAPNVLYREADNVSNFQTTTQAET 924
+ V H+ M+ N+STV AP L R+ N + Q T+ T
Sbjct: 779 --IAHLGRVCKHAEKNLMNSKNVSTVFAP-TLMRDKVNRFDLQHATKKST 825
>Hs21264337_1 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1348
Score = 60.5 bits (145), Expect = 1e-08
Identities = 43/154 (27%), Positives = 74/154 (47%), Gaps = 6/154 (3%)
Query: 753 SKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQ 812
S+ IPI+VD IS + Q + +EGV+RK G R L+ E + E+ ++
Sbjct: 915 SRGDIPIIVDACISFVTQHGLRLEGVYRKGGARARSLRLLAEFRRDARSVKLRPGEHFVE 974
Query: 813 -LSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVI 871
++D LK+F REL +P+ + L W A +L + ++ + + LPR R +
Sbjct: 975 DVTDTLKRFFRELDDPVTSARLLPRWREAAELPQKNQRLEKYKDVIGCLPRVNRRTLATL 1034
Query: 872 FSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNV 905
LY + + ++M NL+ + AP+V
Sbjct: 1035 IGHLYRVQKCAAL-----NQMCTRNLALLFAPSV 1063
>HsM7019433 [R] KOG3564 GTPase-activating protein
Length = 632
Score = 60.1 bits (144), Expect = 2e-08
Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 8/157 (5%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSK-ENVIQLSD 815
IP +V ++ + Q ++ G++R +G R +K L E+ + + P LSK +++ +
Sbjct: 362 IPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKF-LRVKTVPLLSKVDDIHAICS 420
Query: 816 LLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFL 875
LLK FLR L PLLTF L ++ A +++D+ A+ LP+ R+ + L
Sbjct: 421 LLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHL 480
Query: 876 YWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADN 912
+ H +KMD+ NL+ V P ++ N
Sbjct: 481 QRVAQSPH------TKMDVANLAKVFGPTIVAHAVPN 511
>Hs21361397 [R] KOG3564 GTPase-activating protein
Length = 632
Score = 60.1 bits (144), Expect = 2e-08
Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 8/157 (5%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSK-ENVIQLSD 815
IP +V ++ + Q ++ G++R +G R +K L E+ + + P LSK +++ +
Sbjct: 362 IPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKF-LRVKTVPLLSKVDDIHAICS 420
Query: 816 LLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFL 875
LLK FLR L PLLTF L ++ A +++D+ A+ LP+ R+ + L
Sbjct: 421 LLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHL 480
Query: 876 YWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADN 912
+ H +KMD+ NL+ V P ++ N
Sbjct: 481 QRVAQSPH------TKMDVANLAKVFGPTIVAHAVPN 511
>Hs14249622 [T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM
proteins
Length = 538
Score = 60.1 bits (144), Expect = 2e-08
Identities = 48/166 (28%), Positives = 66/166 (38%), Gaps = 22/166 (13%)
Query: 45 CADCKKPIH--SNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHY- 101
C C K I+ SNA +AL S YH C VC CG + K F Y + S + C++ Y
Sbjct: 338 CIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAF-YSVNGS----VYCEEDYL 392
Query: 102 ---FTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKC--KVDECFHHYDNLYC 156
F C VC + GK Y F C +C KC + + +YC
Sbjct: 393 FSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVC-NKCLDGIPFTVDFSNQVYC 451
Query: 157 KYHFLKYLSRRCEGCGYPISD--------QYIEFQKGDKMECWHTE 194
+ K + +C CG PI + I + EC+H E
Sbjct: 452 VTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCE 497
>7300563 [T] KOG4270 GTPase-activator protein
Length = 740
Score = 60.1 bits (144), Expect = 2e-08
Identities = 51/188 (27%), Positives = 87/188 (46%), Gaps = 21/188 (11%)
Query: 731 FGTPL-EYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLK 789
FGT L E+LTS + +I +V+ L + + EG+ R +L+
Sbjct: 249 FGTSLKEHLTS------------TNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLR 296
Query: 790 LLVEEIDNQPQHCP-DLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKR 848
+ ++ Q P L ++ + +LK +LRELP PLLT++LY +I + +
Sbjct: 297 RMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAE 356
Query: 849 KERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSG-SKMDIHNLSTVIAPNVLY 907
++ ++ + T LP+ E + Y S V S +KM NL+ V++PN+L+
Sbjct: 357 RKTEIKAILTKLPK------ENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLW 410
Query: 908 READNVSN 915
D SN
Sbjct: 411 PRIDKSSN 418
>Hs20977541 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 1957
Score = 59.7 bits (143), Expect = 2e-08
Identities = 47/169 (27%), Positives = 77/169 (44%), Gaps = 17/169 (10%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEE-------IDNQPQHCPDLSKEN 809
IP++VD + + + G++R GN + + EE ID Q DL N
Sbjct: 1160 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDL---N 1216
Query: 810 VIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAE 869
VI S LLK F R+LP PL T Y +I A + D + + L+ L LP ++ +
Sbjct: 1217 VI--SSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLK 1274
Query: 870 VIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSNFQT 918
+ + L + + +KM+ NL+ V P ++ DN+++ T
Sbjct: 1275 FLSAHLKTVA-----ENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVT 1318
>Hs11496885 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 457
Score = 59.3 bits (142), Expect = 3e-08
Identities = 45/187 (24%), Positives = 69/187 (36%), Gaps = 16/187 (8%)
Query: 17 PNTEEVLPNRTESYMAVKSK-----SSPRPTRQCADCKKPIHSNALKALGSHYHENCLVC 71
P T L +RT A S+ T C C K I L ALG YH VC
Sbjct: 249 PATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVC 308
Query: 72 YDCGAICKPKYFPYDLPDSKETVLLCQKHYFTRNNLLCSVCKEPLSGIYFNTFGKLYDEQ 131
CG + + F ++ + C Y R C+ CK+ ++G + +
Sbjct: 309 SQCGKVLEEGGF-----FEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVH 363
Query: 132 HFCCSLCGEKCKVDECFHHYDNLYCKYHFLKYLSRRCEGCGYPI--SDQYIEFQKGDKME 189
F C+ C + + YC+ + K +C GC + I D+++E
Sbjct: 364 CFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS--- 420
Query: 190 CWHTECY 196
WH C+
Sbjct: 421 -WHDTCF 426
>Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 316
Score = 58.9 bits (141), Expect = 4e-08
Identities = 37/156 (23%), Positives = 83/156 (52%), Gaps = 7/156 (4%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSK-ENVIQLSD 815
+P V I + + + ++G++R +GN+ ++ L +++ + + SK E++ ++
Sbjct: 139 VPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITG 198
Query: 816 LLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFL 875
LK F RELP PL TF+ +N ++NA K + +++ A++ L LP+ ++ +++F L
Sbjct: 199 ALKMFFRELPEPLFTFNHFNDFVNAIK-QEPRQRVAAVKDLIRQLPKPNQDTMQILFRHL 257
Query: 876 YWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREAD 911
++ ++M +++ V P +L E +
Sbjct: 258 RRV-----IENGEKNRMTYQSIAIVFGPTLLKPEKE 288
>Hs13491176 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 383
Score = 58.9 bits (141), Expect = 4e-08
Identities = 50/199 (25%), Positives = 96/199 (48%), Gaps = 18/199 (9%)
Query: 730 VFGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLK 789
+FG PL L ++ D P +K+P+++ + + + + EG+FR +G ++K
Sbjct: 38 IFGVPLTVL-----LDGDRKKDPG-VKVPLVLQKFFEKVEESGLESEGIFRLSGCTAKVK 91
Query: 790 LLVEEIDNQPQHCPDLSKENVI---QLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQ 846
EE+D + D K + + + + +LK F RELP L +I+ +
Sbjct: 92 QYREELD--AKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPH 149
Query: 847 -KRKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNV 905
K + +AL L+ LP R+ A+ + +F + S ++M + N+STV+APN+
Sbjct: 150 VKVQFQALHLMVMALPDANRDAAQALMTFFN-----KVIANESKNRMSLWNISTVMAPNL 204
Query: 906 LYREADNVSNFQTTTQAET 924
+ + + S+++ A T
Sbjct: 205 FFSRSKH-SDYEELLLANT 222
>Hs10835201 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 822
Score = 58.2 bits (139), Expect = 6e-08
Identities = 51/195 (26%), Positives = 86/195 (43%), Gaps = 9/195 (4%)
Query: 733 TPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLV 792
TP + T GV+ + P +V + + + + + G++R +G ++ L
Sbjct: 599 TPSKKQTGVFGVKISVVTKREVQGAPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALK 658
Query: 793 EEID-NQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKER 851
D N LS ++ ++ LK + RELP PLLT LY ++ LSD KE
Sbjct: 659 AVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKEN 718
Query: 852 ALELLYTMLPRYYRNVAEVIFSFLYWASSFSHV-DGHSGSKMDIHNLSTVIAPNVLYREA 910
+ L LP + +FL+ V + +KM +HNL+TV P +L R +
Sbjct: 719 CMMHLVRSLP------DPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLL-RPS 771
Query: 911 DNVSNFQTTTQAETY 925
+ S T+ A+ +
Sbjct: 772 EVESKAHLTSAADIW 786
>YDR379w_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 868
Score = 57.8 bits (138), Expect = 8e-08
Identities = 49/189 (25%), Positives = 96/189 (49%), Gaps = 44/189 (23%)
Query: 754 KLKIPILVDELISSLRQLD--MSVEGVFRKNGNIRRLKLLVEEIDNQ-----PQHCPDLS 806
K +PI++ I + + D +++EG++RK+G+ + LVEEI+N+ H LS
Sbjct: 657 KSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGS----QTLVEEIENEFAQNNSLHSDTLS 712
Query: 807 -------KENVIQLSDLLKKFLRELPNPLLTFSLYNHWI--------------NATKLSD 845
+++ ++ +LK++LR+LP+P+L+FS+Y+ I N K D
Sbjct: 713 PKLNALLNQDIHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLD 772
Query: 846 QKRKERALEL-------LYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLS 898
+K E+ ++ +LP ++ V +V+ + + S + M++HNLS
Sbjct: 773 SPQKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCS-----ERNLMNLHNLS 827
Query: 899 TVIAPNVLY 907
V AP++++
Sbjct: 828 LVFAPSLIH 836
>SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 695
Score = 57.0 bits (136), Expect = 1e-07
Identities = 41/169 (24%), Positives = 83/169 (48%), Gaps = 9/169 (5%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQ---HCPDLSKENVIQL 813
IP +V + S + ++++G++R + R+ +L + +N P H P+ + +V +
Sbjct: 519 IPNIVMQCTSQVENFGLNLQGIYRVPSSSARVNMLRSQFENNPLLQLHTPEDYENDVHAV 578
Query: 814 SDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFS 873
+DLLK F REL PL+ + +I+A + D+ R+ A+ LP N + +
Sbjct: 579 ADLLKIFFRELREPLIPDNHQRDFIDAGNVEDESRRRDAVHRAINDLPD--ANYSTIRHL 636
Query: 874 FLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREA-DNVSNFQTTTQ 921
++ A + D +KM +NL+ + P ++ + +S+F T +
Sbjct: 637 TIHLAKIKENSD---VNKMSTNNLAIIWGPTIIKQATIPEISSFSRTIE 682
>CE15896 [TZR] KOG1704 FOG: LIM domain
Length = 454
Score = 57.0 bits (136), Expect = 1e-07
Identities = 43/208 (20%), Positives = 78/208 (36%), Gaps = 16/208 (7%)
Query: 20 EEVLPNRTESYMAVKSKSSP-RPTRQCADCKKPIHSNALKALG------SHYHENCLVCY 72
EE + R E + + SS +C C + +N + + + +H C C
Sbjct: 90 EEFVNARNEIALDIGYVSSNINKAMECHKCSGILETNEMAVIAPKLGDSTGWHPACFTCQ 149
Query: 73 DCGAICKPKYFPYDLPDSKETVLLCQKHYFTRNNLLCSVCKEPL-SGIYFNTFGKLYDEQ 131
C + + K+ + C++HY + CS C E + +G Y K +
Sbjct: 150 ACEQLLVDLTYCV-----KDNQIYCERHYAELHKPRCSACDELIFAGEYTKAMNKDWHSD 204
Query: 132 HFCCSLCGEKCKVDECFHHYDNLYCKYHFLKYLSRRCEGCGYPISDQYIEFQKGDKMECW 191
HFCC C + + YC + + +C+ C PI + DK W
Sbjct: 205 HFCCWQCDQTLTGQRYIMRDEQPYCIKCYEDVFANQCDECAKPIGIDSKDLSYKDKH--W 262
Query: 192 HTECYGIHKYWHVTISPEDFGLPNLKVY 219
H C+ + +++ FG N +++
Sbjct: 263 HEHCF-LCSMCKISLVDMPFGSKNDRIF 289
>CE15895 [TZR] KOG1704 FOG: LIM domain
Length = 525
Score = 57.0 bits (136), Expect = 1e-07
Identities = 43/208 (20%), Positives = 78/208 (36%), Gaps = 16/208 (7%)
Query: 20 EEVLPNRTESYMAVKSKSSP-RPTRQCADCKKPIHSNALKALG------SHYHENCLVCY 72
EE + R E + + SS +C C + +N + + + +H C C
Sbjct: 90 EEFVNARNEIALDIGYVSSNINKAMECHKCSGILETNEMAVIAPKLGDSTGWHPACFTCQ 149
Query: 73 DCGAICKPKYFPYDLPDSKETVLLCQKHYFTRNNLLCSVCKEPL-SGIYFNTFGKLYDEQ 131
C + + K+ + C++HY + CS C E + +G Y K +
Sbjct: 150 ACEQLLVDLTYCV-----KDNQIYCERHYAELHKPRCSACDELIFAGEYTKAMNKDWHSD 204
Query: 132 HFCCSLCGEKCKVDECFHHYDNLYCKYHFLKYLSRRCEGCGYPISDQYIEFQKGDKMECW 191
HFCC C + + YC + + +C+ C PI + DK W
Sbjct: 205 HFCCWQCDQTLTGQRYIMRDEQPYCIKCYEDVFANQCDECAKPIGIDSKDLSYKDKH--W 262
Query: 192 HTECYGIHKYWHVTISPEDFGLPNLKVY 219
H C+ + +++ FG N +++
Sbjct: 263 HEHCF-LCSMCKISLVDMPFGSKNDRIF 289
>7290597 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 494
Score = 57.0 bits (136), Expect = 1e-07
Identities = 40/154 (25%), Positives = 75/154 (47%), Gaps = 9/154 (5%)
Query: 756 KIPILVDELISSLRQLDMSVEGVFRKNG---NIRRLKLLVEEIDNQPQHCPDLSKENVIQ 812
+IP +V + + M EG++R +G I LKL ++ + + + + NV
Sbjct: 317 QIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDR-EGEKTDMSETAYGNVNV 375
Query: 813 LSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIF 872
++ LK +LR LP PL+TF Y ++ A + Q + + + LP + + + +
Sbjct: 376 IAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYML 435
Query: 873 SFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVL 906
L +S ++ +KM+ HNL+TV AP ++
Sbjct: 436 EHLKRVASH-----YAVNKMNEHNLATVFAPTLI 464
>CE18872 [R] KOG3564 GTPase-activating protein
Length = 681
Score = 56.6 bits (135), Expect = 2e-07
Identities = 40/156 (25%), Positives = 81/156 (51%), Gaps = 9/156 (5%)
Query: 753 SKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQ 812
+K IP V + +L ++ EG++R G +R + +L++E+ ++ P++ +V
Sbjct: 432 AKPMIPAAVIHCVVALEARGLTQEGIYRVPGQVRTVNVLLDELRSKT--VPNVGLHDVEV 489
Query: 813 LSDLLKKFLRELPNPLLTFSLYNHWINATKL--SDQKRKERALELLYTMLPRYYRNVAEV 870
++D LK+FLR+L +PL+ + I A L +D AL + LP+ R+ +
Sbjct: 490 ITDTLKRFLRDLKDPLIPRTSRQELIVAANLYSTDPDNGRLALNRVICELPQANRDT--L 547
Query: 871 IFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVL 906
+ F++W + S +KM+ ++ ++AP V+
Sbjct: 548 AYLFIHWRKVIAQ---SSRNKMNCEAMARMVAPAVM 580
>CE04392 [TZ] KOG2272 Focal adhesion protein PINCH-1 contains LIM domains
Length = 348
Score = 55.8 bits (133), Expect = 3e-07
Identities = 34/141 (24%), Positives = 62/141 (43%), Gaps = 6/141 (4%)
Query: 45 CADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFTR 104
C C +PI + ALG H+H VC ++C+ + + + K + C++H+
Sbjct: 205 CGACHRPIEERVIAALGKHWHVEHFVC----SVCEKPFLGHRHYERKG-LPYCEQHFHKL 259
Query: 105 NNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYD-NLYCKYHFLKY 163
LC C +P G F K + + F CS C +K F+ +D CK + ++
Sbjct: 260 FGNLCFKCGDPCCGEVFQALQKTWCVKCFSCSFCDKKLDQKTKFYEFDMKPTCKRCYDRF 319
Query: 164 LSRRCEGCGYPISDQYIEFQK 184
+ + + D+ +E Q+
Sbjct: 320 PTELKKRISESLKDRDVENQR 340
>Hs16445031 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 995
Score = 55.5 bits (132), Expect = 4e-07
Identities = 56/244 (22%), Positives = 105/244 (42%), Gaps = 27/244 (11%)
Query: 664 YYSELTSEQYYILQIIAFSLLNSEGFDMQQIKPPDFPHKMSNNNGLWTKFKTIMGGXXXX 723
+ S T+ Q +LQ FSLL M++ H MSN +G M
Sbjct: 486 HISSQTASQLSLLQ--RFSLLRLTAI-MEK-------HSMSNKHGWTWSVPKFMKRMKVP 535
Query: 724 XXXXXXVFGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNG 783
VFG PL G +P + + + LR + G+FRK+G
Sbjct: 536 DYKDKAVFGVPLIVHVQRTGQP-----------LPQSIQQALRYLRSNCLDQVGLFRKSG 584
Query: 784 NIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKL 843
R+ L + +N P++ + ++ ++D++K+F R+LP PL T L +++ +
Sbjct: 585 VKSRIHALRQMNENFPENV-NYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQY 643
Query: 844 SDQKRKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAP 903
++++ +A++ +L R V + + FL V+ ++M NL+ +AP
Sbjct: 644 VSKEQRLQAVQAAILLLADENREVLQTLLCFLN-----DVVNLVEENQMTPMNLAVCLAP 698
Query: 904 NVLY 907
++ +
Sbjct: 699 SLFH 702
>CE17831 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 769
Score = 55.5 bits (132), Expect = 4e-07
Identities = 44/169 (26%), Positives = 75/169 (44%), Gaps = 11/169 (6%)
Query: 743 GVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHC 802
GV D+ + +P + E++ LR + G+FRKNG R+ L I++ +
Sbjct: 389 GVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNT 448
Query: 803 PDLSKENVIQ------LSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELL 856
EN++ ++DLLK++ R+LP PL+T + + N + + AL+
Sbjct: 449 DVFVGENLLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYA 508
Query: 857 YTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNV 905
+LP R + + FL S S V + M NLS P++
Sbjct: 509 ILLLPDENREALKTLLLFLKEVSRNSQV-----NNMTAQNLSVCFTPSL 552
>CE01007 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 649
Score = 55.5 bits (132), Expect = 4e-07
Identities = 44/169 (26%), Positives = 75/169 (44%), Gaps = 11/169 (6%)
Query: 743 GVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHC 802
GV D+ + +P + E++ LR + G+FRKNG R+ L I++ +
Sbjct: 269 GVGLDVIFNRTGYFLPRPILEVMKFLRNIAPETVGIFRKNGVKSRIAELRSIIESYSGNT 328
Query: 803 PDLSKENVIQ------LSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELL 856
EN++ ++DLLK++ R+LP PL+T + + N + + AL+
Sbjct: 329 DVFVGENLLDSTQVHDVADLLKQYFRDLPEPLMTVKMSEVFANICSVVPDVERITALQYA 388
Query: 857 YTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNV 905
+LP R + + FL S S V + M NLS P++
Sbjct: 389 ILLLPDENREALKTLLLFLKEVSRNSQV-----NNMTAQNLSVCFTPSL 432
>Hs7661882 [T] KOG4270 GTPase-activator protein
Length = 638
Score = 55.1 bits (131), Expect = 5e-07
Identities = 42/159 (26%), Positives = 83/159 (51%), Gaps = 10/159 (6%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKE-NVIQLSD 815
+PILV++ + + + EG+FR G +K L + D + P ++ +V ++
Sbjct: 169 VPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGER--PSFDRDTDVHTVAS 226
Query: 816 LLKKFLRELPNPLLTFSLYNHWINATKL--SDQKRKERALELLYTMLPRYYRNVAEVIFS 873
LLK +LR+LP P++ +S Y ++ +L +D+ + ++ L ++LPR ++ I
Sbjct: 227 LLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICR 286
Query: 874 FLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADN 912
FL+ V +KM + NL+TVI N++ + ++
Sbjct: 287 FLHEIQLNCAV-----NKMSVDNLATVIGVNLIRSKVED 320
>Hs22055163 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 727
Score = 55.1 bits (131), Expect = 5e-07
Identities = 43/173 (24%), Positives = 68/173 (38%), Gaps = 14/173 (8%)
Query: 42 TRQCADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHY 101
T C C I L A+G +H C A CK + + V C++ Y
Sbjct: 548 TPLCGHCNNVIRGPFLVAMGRSWHPEEFTC----AYCKTSLADVCFVEEQNNVY-CERCY 602
Query: 102 FTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNL-YCKYHF 160
LC+ C + G + + + F C+ C +K + FH D YC+ +
Sbjct: 603 EQFFAPLCAKCNTKIMGEVMHALRQTWHTTCFVCAAC-KKPFGNSLFHMEDGEPYCEKDY 661
Query: 161 LKYLSRRCEGCGYPI--SDQYIEFQKGDKMECWHTECYGIHKYWHVTISPEDF 211
+ S +C GC +P+ D++IE WH C+ I HV + + F
Sbjct: 662 INLFSTKCHGCDFPVEAGDKFIEALG----HTWHDTCF-ICAVCHVNLEGQPF 709
>Hs19924173 [TZR] KOG1704 FOG: LIM domain
Length = 284
Score = 55.1 bits (131), Expect = 5e-07
Identities = 40/163 (24%), Positives = 70/163 (42%), Gaps = 15/163 (9%)
Query: 44 QCADCKKPIH--SNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHY 101
+C CK+ I S ++ G+++HE C VC +C K P +S + C +
Sbjct: 101 KCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTK--PLISKESGNYCVPCFEKE 158
Query: 102 FTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHFL 161
F C+ CK+ ++ +L+ ++ F CS C + ++ D +C +
Sbjct: 159 FAH---YCNFCKKVITSGGITFCDQLWHKECFLCSGCRKDLCEEQFMSRDDYPFCVDCYN 215
Query: 162 KYLSRRCEGCGYPISD----QYIEFQKGDKMECWHTECYGIHK 200
+ +C C PIS ++I FQ WH+EC+ K
Sbjct: 216 HLYANKCVACSKPISGLTGAKFICFQDSQ----WHSECFNCGK 254
Score = 54.7 bits (130), Expect = 7e-07
Identities = 42/156 (26%), Positives = 57/156 (35%), Gaps = 13/156 (8%)
Query: 45 CADCKKPIHSNA--LKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYF 102
C +CKKPI S++ L H+HE C C C K F +K+ LLC + Y
Sbjct: 41 CEECKKPIESDSKDLCYKDRHWHEGCFKCTKCNHSLVEKPFA-----AKDERLLCTECYS 95
Query: 103 TRNNLLCSVCKEPL--SGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYHF 160
+ C CK + G + E F C C + YC F
Sbjct: 96 NECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCENCRQPIGTKPLISKESGNYCVPCF 155
Query: 161 LKYLSRRCEGCGYPISDQYIEFQKGDKMECWHTECY 196
K + C C I+ I F + WH EC+
Sbjct: 156 EKEFAHYCNFCKKVITSGGITFCD----QLWHKECF 187
>CE16059 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 718
Score = 54.3 bits (129), Expect = 9e-07
Identities = 46/168 (27%), Positives = 80/168 (47%), Gaps = 15/168 (8%)
Query: 756 KIPILVDELISSLRQLDMSVEGVFRKNG---NIRRLKLLVEEIDNQPQHCPDLSKENVIQ 812
K+P++V++ +S+ + V G++R+ G NI+RL+ + H + + ++
Sbjct: 251 KVPVIVEKCCASIEDQGI-VTGIYRQCGIQSNIQRLRAKFDSGAEPDLH--EFGQRDIYS 307
Query: 813 LSDLLKKFLRELPNPLLTFSLYNHWINATKLSD--QKRKERALELLYTMLPRYYRNVAEV 870
+S LLK++ R+LPNPL T+ Y I A + D ++ E L TM +YR +
Sbjct: 308 VSSLLKQYFRQLPNPLFTYQAYPKLIEAFEKEDSLSEKVESLRFSLETMPEAHYRTAKFL 367
Query: 871 IFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSNFQT 918
+ S S D M NL+ V +PN L+R ++ T
Sbjct: 368 MEHLTRLCKSKSLTD------MTSKNLAIVWSPN-LFRPPPTLNGADT 408
>7292937 [T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM
proteins
Length = 728
Score = 54.3 bits (129), Expect = 9e-07
Identities = 40/164 (24%), Positives = 69/164 (41%), Gaps = 19/164 (11%)
Query: 45 CADCKKPIHS--NALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHY- 101
C C + + A +A+G+ YH NC +C CG + K F Y++ + C++ Y
Sbjct: 516 CHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGKAF-YNVHGR----VYCEEDYM 570
Query: 102 ---FTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDN-LYCK 157
F + C++C + + GK Y F C +C E D+ +YC
Sbjct: 571 YSGFQQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCV 630
Query: 158 YHFLKYLSRRCEGCGYPI-----SDQYIEFQKGDKMECWHTECY 196
+ + + +C CG I +D+ + DK +H +CY
Sbjct: 631 NDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDK--DFHVDCY 672
>7302107 [T] KOG1452 Predicted Rho GTPase-activating protein
Length = 1844
Score = 53.9 bits (128), Expect = 1e-06
Identities = 47/191 (24%), Positives = 83/191 (42%), Gaps = 25/191 (13%)
Query: 730 VFGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLK 789
+FG LE + V + P +PI++ + + + + + G++R G+ + +
Sbjct: 920 LFGADLETV-----VNRESKNAPGSAPVPIVLRRCVEEVERRGLDIIGLYRLCGSATKKR 974
Query: 790 LLVEEIDNQ-------PQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATK 842
LL E + P+H PD+ NVI + +LK +LRELP PL T L+ ++A
Sbjct: 975 LLREAFERNSRAVELTPEHVPDI---NVI--TGVLKDYLRELPEPLFTRCLFQMTVDALA 1029
Query: 843 L---SDQKRKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLST 899
+ D + + + + LPR R + L V +KM L+T
Sbjct: 1030 VCLPDDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLV-----VSNSERNKMSAQALAT 1084
Query: 900 VIAPNVLYREA 910
V+ P ++ A
Sbjct: 1085 VMGPPLMLHSA 1095
>YOR127w_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 884
Score = 53.9 bits (128), Expect = 1e-06
Identities = 46/201 (22%), Positives = 94/201 (45%), Gaps = 49/201 (24%)
Query: 738 LTSHCGVESDLGVGPSKLKIPILVDELISSLR--QLDMSVEGVFRKNGNIRRLKLLVEEI 795
L + C E++ +IP+++ I + + +M EG++RK+G+ +L++EEI
Sbjct: 670 LVARCNYENN--------EIPMILSVCIDFIESDEENMRSEGIYRKSGS----QLVIEEI 717
Query: 796 DNQ--------PQHCPD-LSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQ 846
+ Q P+ L+++++ ++ +LK++LR+LPNP+ TF +Y + K
Sbjct: 718 EKQFSAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKM 777
Query: 847 KR---------------------KERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVD 885
+ AL+ + LPR + V V+ + + +SH
Sbjct: 778 MENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSH-- 835
Query: 886 GHSGSKMDIHNLSTVIAPNVL 906
++M ++NL+ V AP ++
Sbjct: 836 ---WNRMTLYNLALVFAPGLI 853
>Hs7656904 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 464
Score = 53.5 bits (127), Expect = 2e-06
Identities = 49/179 (27%), Positives = 86/179 (47%), Gaps = 21/179 (11%)
Query: 731 FGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKL 790
FG L+YL D G IP ++ ++ LR+ + EG+FR++ +++ ++
Sbjct: 224 FGVSLQYL-------KDKNQGEL---IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVRE 273
Query: 791 LVEEIDNQ--PQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKR 848
++ + NQ P + D ++ + +LK FLRELP PLLTF Y + T + R
Sbjct: 274 -IQRLYNQGKPVNFDDYGDIHIPAV--ILKTFLRELPQPLLTFQAYEQILGITCVESSLR 330
Query: 849 KERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLY 907
++L + LP + V + FL+ S S +KM+ NL+ V N+++
Sbjct: 331 VTGCRQILRS-LPEHNYVVLRYLMGFLHAVSRESIF-----NKMNSSNLACVFGLNLIW 383
>Hs5453714 [TZ] KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins
Length = 596
Score = 53.5 bits (127), Expect = 2e-06
Identities = 30/118 (25%), Positives = 49/118 (41%), Gaps = 7/118 (5%)
Query: 44 QCADCKKPIHSNALKALGSHYHENCLVCYDCGAICKPKYFPYDLPDSKETVLLCQKHYFT 103
+C C++ I + AL +H +C VC CG + F L D + C+ Y+
Sbjct: 478 ECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIRNNVF--HLEDGEP---YCETDYYA 532
Query: 104 RNNLLCSVCKEPLSG--IYFNTFGKLYDEQHFCCSLCGEKCKVDECFHHYDNLYCKYH 159
+C C+ P+ ++ G + + F CS+C E + F D CK H
Sbjct: 533 LFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 590
Score = 53.1 bits (126), Expect = 2e-06
Identities = 47/185 (25%), Positives = 69/185 (36%), Gaps = 23/185 (12%)
Query: 17 PNTEEVLPNRTESYMAVKSKSSPRPTRQCADCKKPIHSNALKALGSHYHENCLVCYDCGA 76
P+ ++ L R E A K T CA C + I L ALG +H C A
Sbjct: 398 PSDQDTLVQRAEHIPAGKR------TPMCAHCNQVIRGPFLVALGKSWHPEEFNC----A 447
Query: 77 ICKPKYFPYDLPDSKETVL--LCQKHYFTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFC 134
CK + K + LC + +F C C+ + G N + + F
Sbjct: 448 HCKNTMAYIGFVEEKGALYCELCYEKFFAPE---CGRCQRKILGEVINALKQTWHVSCFV 504
Query: 135 CSLCGEKCKVDECFHHYD-NLYCKYHFLKYLSRRCEGCGYPI--SDQYIEFQKGDKMECW 191
C CG+ + + FH D YC+ + C GC +PI D ++E W
Sbjct: 505 CVACGKPIR-NNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALG----YTW 559
Query: 192 HTECY 196
H C+
Sbjct: 560 HDTCF 564
>Hs22056100_1 [TZ] KOG2710 Rho GTPase-activating protein
Length = 233
Score = 53.5 bits (127), Expect = 2e-06
Identities = 42/131 (32%), Positives = 62/131 (47%), Gaps = 33/131 (25%)
Query: 776 EGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDLLKKFLRELPNPLLTFSLYN 835
EG+FRK+G++ RLK L KF RELP P+L L+
Sbjct: 55 EGLFRKSGSVIRLKAL---------------------------KFFRELPEPILPADLHE 87
Query: 836 HWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIH 895
+ A +L ++ K +A+ LL +L + +V F+FL S S S +KMD
Sbjct: 88 ALLKAQQLGTEE-KNKAILLLSCLLADHTVHVLRYFFNFLRNVSLRS-----SENKMDSS 141
Query: 896 NLSTVIAPNVL 906
NL+ + APN+L
Sbjct: 142 NLAVIFAPNLL 152
>Hs7662330 [TZ] KOG1044 Actin-binding LIM Zn-finger protein Limatin involved
in axon guidance
Length = 683
Score = 52.4 bits (124), Expect = 3e-06
Identities = 33/111 (29%), Positives = 48/111 (42%), Gaps = 15/111 (13%)
Query: 34 KSKSSPRPTR-----QCADCKKPI-HSNALKALGSHYHENCLVCYDCGAICKPKYFPYDL 87
+S +S +P + CA CK+ I H +L AL +H +C C C I +Y
Sbjct: 135 QSMASSKPIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILTGEYI---- 190
Query: 88 PDSKETVLLCQKHYFTRNNLLCSVCKEPLSGIYFNTFGKLYDEQHFCCSLC 138
SK+ V C+ Y + + C C +SG GK Y H C+ C
Sbjct: 191 --SKDGVPYCESDYHAQFGIKCETCDRYISGRVLEAGGKHY---HPTCARC 236
>CE21517 [T] KOG4270 GTPase-activator protein
Length = 604
Score = 52.4 bits (124), Expect = 3e-06
Identities = 45/177 (25%), Positives = 79/177 (44%), Gaps = 18/177 (10%)
Query: 730 VFGTPLEYLTSHCGVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLK 789
VFG PL+ H ++ + +I ++ + LRQ M+ G+FR +GN ++K
Sbjct: 238 VFGVPLD---EHLSIQKE--------RISGVLTKCCDFLRQNGMNERGIFRVSGNASKIK 286
Query: 790 LLVEEIDNQPQHCPDLSKENVIQ-LSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKR 848
+ +D + N ++ LK +LRELP+PL SL + W+ A L ++R
Sbjct: 287 RIRAALDAGQFDADEKHYNNDPHAVASTLKAYLRELPDPLTMDSLQSDWVEAINLEGEER 346
Query: 849 KERALELLYTMLPRYYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNV 905
A++ + R +R + FL + + M+ NL+ V AP +
Sbjct: 347 FS-AIDRCLKKMTRGHRQNLIYLMKFLCDLEA-----KREETSMNASNLAIVFAPTM 397
>ECU05g0710 [TZ] KOG2710 Rho GTPase-activating protein
Length = 287
Score = 52.0 bits (123), Expect = 5e-06
Identities = 37/154 (24%), Positives = 72/154 (46%), Gaps = 9/154 (5%)
Query: 764 LISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKE--------NVIQLSD 815
L ++ LD V G+FR +I +K V+ I++ S+ NVI L+
Sbjct: 97 LTETVLSLDCRVGGIFRVRNSITTIKECVKAINSCVDRNLSYSEARRLLIRDFNVIDLTT 156
Query: 816 LLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFL 875
K+ LRE ++ SL + K+ +++ + ++L+ +P+ R+V E FL
Sbjct: 157 AFKEILREYSTTIIPESLIDTMFKIAKVENEEDQVILCQMLFISMPKTNRHVLEATIYFL 216
Query: 876 YWASSFSHVDG-HSGSKMDIHNLSTVIAPNVLYR 908
Y + G + M++ +ST++ PN++ +
Sbjct: 217 YVIHDIATDKGKNHKDNMNMEGISTIMMPNLVIK 250
>Hs7706107 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 970
Score = 51.6 bits (122), Expect = 6e-06
Identities = 40/164 (24%), Positives = 77/164 (46%), Gaps = 20/164 (12%)
Query: 756 KIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSD 815
++P +V + + + + V+G++R +G+ R++ L + +N + +LS + +S
Sbjct: 563 EVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENG-RALVELSGNSPHDVSS 621
Query: 816 LLKKFLRELPNPLLTFSLYNHWINATKL------------SDQKRKERALELLYTMLP-R 862
+LK+FL+EL P++ F LY+ +I+ K S R+L+ L LP
Sbjct: 622 VLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPDVIRSLKTLLVQLPDS 681
Query: 863 YYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVL 906
Y + ++ A+ F +KM +NL V P +L
Sbjct: 682 NYNTLRHLVAHLFRVAARFME------NKMSANNLGIVFGPTLL 719
>Hs7661982 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 1023
Score = 51.6 bits (122), Expect = 6e-06
Identities = 35/151 (23%), Positives = 72/151 (47%), Gaps = 7/151 (4%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDL 816
+P + + + LR + G+FRK+G R++ L + + P + ++ ++DL
Sbjct: 585 LPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLRQMNETSPDNVC-YEGQSAYDVADL 643
Query: 817 LKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVIFSFLY 876
LK++ R+LP P+ T L ++ +L + + A + +LP R V + + FL
Sbjct: 644 LKQYFRDLPEPIFTSKLTTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFL- 702
Query: 877 WASSFSHVDGHSGSKMDIHNLSTVIAPNVLY 907
S + ++M NL+ +AP++ +
Sbjct: 703 -----SDIASAEENQMTAGNLAVCLAPSIFH 728
>YBR260c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 666
Score = 51.2 bits (121), Expect = 8e-06
Identities = 68/298 (22%), Positives = 116/298 (38%), Gaps = 58/298 (19%)
Query: 639 IPGTNKDFTASGDNVPTKKATNSNIYYSELTSEQYYILQI------IAFSLLNSEGFDMQ 692
+P T +S N + +S+I S+ TS L I L+NS D
Sbjct: 390 LPPTMASSISSTSNAAGAMSPSSSIVTSDTTSSITKTLDPGNNSPQIPEELINSLDSDRP 449
Query: 693 QIKPPDFPHKMSNNN---GLWTKFKTIMGGXXXXXXXXXXVFGTPLEYLTSHCGVESDLG 749
H +NNN G+ FKT FG PLE L E D+
Sbjct: 450 ------ISHIQTNNNMPPGVQKNFKT---------------FGVPLESLIEF---EQDM- 484
Query: 750 VGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDL---- 805
+P +V + I + + + EG++RK+ N+ + L EEID P + +
Sbjct: 485 -------VPAIVRQCIYVIDKFGLDQEGIYRKSANVLDVSKLKEEIDKDPANISMILPSK 537
Query: 806 --SKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALE-LLYTMLPR 862
S ++ + LLK F LP+ +L +L + ++ D ++ + L+Y +
Sbjct: 538 PHSDSDIYLVGSLLKTFFASLPDSVLPKALSSEIKVCLQIEDPTTRKNFMHGLIYNLPDA 597
Query: 863 YYRNVAEVIFSFLYWASSFSHVDGHSG-SKMDIHNLSTVIAPNVLYREADNVS--NFQ 917
Y + ++F V H ++M++ L + P + D+ + NFQ
Sbjct: 598 QYWTLRALVF-------HLKRVLAHEAQNRMNLRALCIIWGPTIAPANPDDANDVNFQ 648
>Hs5174427 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 1091
Score = 51.2 bits (121), Expect = 8e-06
Identities = 45/235 (19%), Positives = 102/235 (43%), Gaps = 7/235 (2%)
Query: 743 GVESDLGVGPSKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHC 802
GV + V + +P + + + LR + G+F+K+G R++ L +++ C
Sbjct: 640 GVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVGLFKKSGVKSRIQAL-RQMNEGAIDC 698
Query: 803 PDLSKENVIQLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPR 862
+ ++ ++D+LK++ R+LP PL+T L ++ + + ++ +A++ +LP
Sbjct: 699 VNYEGQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPD 758
Query: 863 YYRNVAEVIFSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSNFQ-TTTQ 921
R V + + FL ++ ++M NL+ +AP++ + N Q
Sbjct: 759 ENRVVLQTLLYFLCDVTA-----AVKENQMTPTNLAVCLAPSLFHLNTLKRENSSPRVMQ 813
Query: 922 AETYVDXXXXXXXXXXXXXXXXXGYLITNNEKLSMVPKYLSDLLDQAEQQQINSL 976
+ + ++I +KL VP+ +S + +Q++ L
Sbjct: 814 RKQSLGKPDQKDLNENLAATQGLAHMIAECKKLFQVPEEMSRCRNSYTEQELKPL 868
>Hs14765644 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1136
Score = 51.2 bits (121), Expect = 8e-06
Identities = 24/86 (27%), Positives = 51/86 (58%), Gaps = 1/86 (1%)
Query: 757 IPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQHCPDLSKENVIQLSDL 816
+P +V + + + + + +G++R NG R++ L + +N + +LS+ + +S++
Sbjct: 774 VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKE-LVELSQASPHDISNV 832
Query: 817 LKKFLRELPNPLLTFSLYNHWINATK 842
LK +LR+LP PL++F LY+ + K
Sbjct: 833 LKLYLRQLPEPLISFRLYHELVGLAK 858
>At5g61530 [T] KOG4270 GTPase-activator protein
Length = 384
Score = 51.2 bits (121), Expect = 8e-06
Identities = 41/166 (24%), Positives = 77/166 (45%), Gaps = 14/166 (8%)
Query: 753 SKLKIPILVDELISSLRQLDMSVEGVFRKNGNIRRLKLLVEEIDNQPQ-HCPDLSKENVI 811
S IP+++ + L ++ +F+ G+ + ++ LV + P+ P+ N +
Sbjct: 158 SSRPIPLILVKCADYLILTGLNSPNLFKAEGDRKLIQQLVSAYNQDPRASIPE--GVNPV 215
Query: 812 QLSDLLKKFLRELPNPLLTFSLYNHWINATKLSDQKRKERALELLYTMLPRYYRNVAEVI 871
++ LLK +L LP PL TF LYN ++ D + + L N E I
Sbjct: 216 DVAALLKYYLASLPTPLTTFELYN------EIKDARSSIHRMRQSLQKLSNVNYNTLEFI 269
Query: 872 FSFLYWASSFSHVDGHSGSKMDIHNLSTVIAPNVLYREADNVSNFQ 917
+ L S S + +KMD H+L+ +AP +++RE + +++
Sbjct: 270 TALLLRVSQKSLL-----NKMDSHSLAMEMAPVIMWREDNRPESYR 310
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.135 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,503,086
Number of Sequences: 60738
Number of extensions: 2677421
Number of successful extensions: 8241
Number of sequences better than 1.0e-05: 98
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 93
Number of HSP's that attempted gapping in prelim test: 7925
Number of HSP's gapped (non-prelim): 239
length of query: 990
length of database: 30,389,216
effective HSP length: 116
effective length of query: 874
effective length of database: 23,343,608
effective search space: 20402313392
effective search space used: 20402313392
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)