ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV4933 check: MH Q KOG1205 Secondary metabolites biosynthesis, transport and catabolism Predicted dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV4933 1697166 1696363 -268
(268 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
Hs7657478 [Q] KOG1205 Predicted dehydrogenase 95 1e-19
Hs20149619 [Q] KOG1205 Predicted dehydrogenase 94 3e-19
Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 94 3e-19
HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 92 6e-19
7290108 [R] KOG0725 Reductases with broad range of substrate spe... 91 1e-18
YMR226c [Q] KOG1205 Predicted dehydrogenase 91 2e-18
7301818 [Q] KOG1205 Predicted dehydrogenase 91 2e-18
Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 91 2e-18
SPAC977.08 [Q] KOG1205 Predicted dehydrogenase 90 4e-18
SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reduct... 90 4e-18
SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase 90 4e-18
Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 89 6e-18
At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductas... 88 1e-17
At3g03330 [Q] KOG1205 Predicted dehydrogenase 82 8e-16
Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 81 2e-15
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 80 3e-15
CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 79 5e-15
Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase 79 9e-15
Hs7706318 [Q] KOG1205 Predicted dehydrogenase 78 1e-14
CE06649 [R] KOG0725 Reductases with broad range of substrate spe... 77 2e-14
At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase 77 2e-14
Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 77 3e-14
CE03954 [R] KOG0725 Reductases with broad range of substrate spe... 77 3e-14
SPCC162.03 [Q] KOG1205 Predicted dehydrogenase 76 4e-14
YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase ... 76 6e-14
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 75 7e-14
7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 75 1e-13
CE03132 [R] KOG0725 Reductases with broad range of substrate spe... 74 2e-13
Hs7705907 [R] KOG0725 Reductases with broad range of substrate s... 74 3e-13
Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 73 5e-13
Hs10337605 [R] KOG0725 Reductases with broad range of substrate ... 73 5e-13
CE03951 [R] KOG0725 Reductases with broad range of substrate spe... 72 6e-13
At3g55310 [R] KOG0725 Reductases with broad range of substrate s... 72 6e-13
At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 72 6e-13
At3g47360 [Q] KOG1205 Predicted dehydrogenase 72 8e-13
Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 72 1e-12
At3g47350 [Q] KOG1205 Predicted dehydrogenase 71 1e-12
7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase 71 2e-12
CE07539 [Q] KOG1205 Predicted dehydrogenase 70 3e-12
At2g29170 [R] KOG0725 Reductases with broad range of substrate s... 70 3e-12
CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 70 4e-12
CE07544 [Q] KOG1205 Predicted dehydrogenase 70 4e-12
At5g06060 [R] KOG0725 Reductases with broad range of substrate s... 69 7e-12
At1g54870 [R] KOG0725 Reductases with broad range of substrate s... 69 9e-12
7297069 [Q] KOG1205 Predicted dehydrogenase 69 9e-12
CE21095 [R] KOG0725 Reductases with broad range of substrate spe... 68 1e-11
CE12990 [R] KOG0725 Reductases with broad range of substrate spe... 68 2e-11
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 68 2e-11
At5g50700 [Q] KOG1205 Predicted dehydrogenase 68 2e-11
At5g50600 [Q] KOG1205 Predicted dehydrogenase 68 2e-11
SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase 67 2e-11
At1g63380 [R] KOG0725 Reductases with broad range of substrate s... 67 2e-11
CE19894 [R] KOG0725 Reductases with broad range of substrate spe... 67 3e-11
At3g46170 [R] KOG0725 Reductases with broad range of substrate s... 67 3e-11
SPAC922.06 [R] KOG0725 Reductases with broad range of substrate ... 67 3e-11
YIR035c [Q] KOG1204 Predicted dehydrogenase 66 4e-11
At1g10310 [R] KOG0725 Reductases with broad range of substrate s... 66 4e-11
At1g62610 [R] KOG0725 Reductases with broad range of substrate s... 66 6e-11
7290988 [Q] KOG1205 Predicted dehydrogenase 66 6e-11
Hs5031737 [R] KOG0725 Reductases with broad range of substrate s... 65 8e-11
Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and... 65 8e-11
CE27260 [R] KOG0725 Reductases with broad range of substrate spe... 65 8e-11
CE14538 [R] KOG0725 Reductases with broad range of substrate spe... 65 1e-10
7296705 [R] KOG0725 Reductases with broad range of substrate spe... 65 1e-10
7295621 [Q] KOG1205 Predicted dehydrogenase 65 1e-10
7295487 [R] KOG0725 Reductases with broad range of substrate spe... 65 1e-10
Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 65 1e-10
CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 65 1e-10
7296047 [Q] KOG1205 Predicted dehydrogenase 64 2e-10
CE27259 [R] KOG0725 Reductases with broad range of substrate spe... 64 2e-10
CE05801 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 64 2e-10
7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 64 2e-10
SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate ... 64 3e-10
7292690 [Q] KOG1205 Predicted dehydrogenase 64 3e-10
7292613 [Q] KOG1205 Predicted dehydrogenase 63 4e-10
Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 63 5e-10
SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase 62 6e-10
At3g05260 [R] KOG0725 Reductases with broad range of substrate s... 62 6e-10
At1g07440 [R] KOG0725 Reductases with broad range of substrate s... 62 6e-10
At2g29150 [R] KOG0725 Reductases with broad range of substrate s... 62 8e-10
At3g26770 [R] KOG0725 Reductases with broad range of substrate s... 62 1e-09
7300731 [Q] KOG1205 Predicted dehydrogenase 62 1e-09
CE02490_1 [R] KOG0725 Reductases with broad range of substrate s... 62 1e-09
YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 61 1e-09
YIR036c [Q] KOG1204 Predicted dehydrogenase 61 1e-09
At2g47120 [R] KOG0725 Reductases with broad range of substrate s... 61 1e-09
At2g29290 [R] KOG0725 Reductases with broad range of substrate s... 61 1e-09
SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase 61 2e-09
Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydrox... 61 2e-09
Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 61 2e-09
CE21092 [R] KOG0725 Reductases with broad range of substrate spe... 61 2e-09
At5g61830 [Q] KOG1208 Dehydrogenases with different specificitie... 61 2e-09
At2g29350 [R] KOG0725 Reductases with broad range of substrate s... 61 2e-09
At1g52340 [R] KOG0725 Reductases with broad range of substrate s... 61 2e-09
7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 61 2e-09
SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate ... 60 2e-09
CE05726 [R] KOG0725 Reductases with broad range of substrate spe... 60 2e-09
Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 60 3e-09
At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase a... 60 3e-09
At2g47130 [R] KOG0725 Reductases with broad range of substrate s... 60 4e-09
YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 59 5e-09
At5g51030 [Q] KOG1208 Dehydrogenases with different specificitie... 59 5e-09
7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 59 5e-09
7296706_2 [R] KOG0725 Reductases with broad range of substrate s... 59 5e-09
CE12594 [R] KOG0725 Reductases with broad range of substrate spe... 59 7e-09
CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 59 7e-09
At1g01800 [Q] KOG1208 Dehydrogenases with different specificitie... 59 7e-09
Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 59 9e-09
Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase 59 9e-09
CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 58 1e-08
At3g59710 [Q] KOG1208 Dehydrogenases with different specificitie... 58 1e-08
At3g42960 [R] KOG0725 Reductases with broad range of substrate s... 58 1e-08
At2g29260 [R] KOG0725 Reductases with broad range of substrate s... 58 1e-08
7300831 [Q] KOG1205 Predicted dehydrogenase 58 1e-08
CE20725 [R] KOG0725 Reductases with broad range of substrate spe... 58 2e-08
YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 57 2e-08
SPCC24B10.20 [R] KOG1611 Predicted short chain-type dehydrogenase 57 2e-08
CE05427 [R] KOG0725 Reductases with broad range of substrate spe... 57 3e-08
At4g10020 [Q] KOG1205 Predicted dehydrogenase 57 3e-08
Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 57 4e-08
At5g50690 [Q] KOG1205 Predicted dehydrogenase 57 4e-08
At5g50590 [Q] KOG1205 Predicted dehydrogenase 57 4e-08
CE09969 [R] KOG0725 Reductases with broad range of substrate spe... 56 5e-08
At2g29310 [R] KOG0725 Reductases with broad range of substrate s... 56 5e-08
7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 56 5e-08
At2g29370 [R] KOG0725 Reductases with broad range of substrate s... 56 6e-08
CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 55 8e-08
At3g26760 [R] KOG0725 Reductases with broad range of substrate s... 55 8e-08
At2g30670 [R] KOG0725 Reductases with broad range of substrate s... 55 8e-08
7294452 [Q] KOG1205 Predicted dehydrogenase 55 8e-08
CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 55 1e-07
7301617_1 [R] KOG0725 Reductases with broad range of substrate s... 55 1e-07
SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase 55 1e-07
CE13008 [R] KOG0725 Reductases with broad range of substrate spe... 55 1e-07
CE15574 [R] KOG0725 Reductases with broad range of substrate spe... 54 2e-07
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 54 3e-07
CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase 54 3e-07
7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 53 4e-07
SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 53 5e-07
At2g29360 [R] KOG0725 Reductases with broad range of substrate s... 53 5e-07
CE21093 [R] KOG0725 Reductases with broad range of substrate spe... 52 7e-07
At3g61220 [Q] KOG1208 Dehydrogenases with different specificitie... 52 9e-07
At2g24190 [Q] KOG1208 Dehydrogenases with different specificitie... 52 9e-07
CE02786 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 52 1e-06
CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 52 1e-06
At3g29260 [R] KOG0725 Reductases with broad range of substrate s... 52 1e-06
At2g29340 [R] KOG0725 Reductases with broad range of substrate s... 52 1e-06
Hs10047132 [R] KOG0725 Reductases with broad range of substrate ... 51 1e-06
At5g04900 [R] KOG0725 Reductases with broad range of substrate s... 51 1e-06
7303531 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 51 1e-06
7295622 [Q] KOG1205 Predicted dehydrogenase 51 1e-06
SPBC16H5.14c [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 51 2e-06
CE03613 [R] KOG1611 Predicted short chain-type dehydrogenase 51 2e-06
At2g37540 [Q] KOG1208 Dehydrogenases with different specificitie... 51 2e-06
7300387 [Q] KOG1208 Dehydrogenases with different specificities ... 51 2e-06
Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 50 3e-06
At4g03140 [R] KOG0725 Reductases with broad range of substrate s... 50 3e-06
At2g29330 [R] KOG0725 Reductases with broad range of substrate s... 50 3e-06
7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 50 3e-06
7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 50 3e-06
At3g29250 [R] KOG0725 Reductases with broad range of substrate s... 50 3e-06
7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 50 3e-06
7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 50 3e-06
CE08181 [Q] KOG1208 Dehydrogenases with different specificities ... 50 4e-06
CE26808_2 [R] KOG0725 Reductases with broad range of substrate s... 50 4e-06
Hs7705925 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 49 6e-06
CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 49 6e-06
Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 49 7e-06
Hs14754051 [R] KOG0725 Reductases with broad range of substrate ... 49 7e-06
CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase 49 7e-06
CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase 49 7e-06
7293189 [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 49 7e-06
Hs4503301 [R] KOG0725 Reductases with broad range of substrate s... 49 1e-05
At4g05530 [R] KOG0725 Reductases with broad range of substrate s... 49 1e-05
>Hs7657478 [Q] KOG1205 Predicted dehydrogenase
Length = 311
Score = 94.7 bits (234), Expect = 1e-19
Identities = 64/194 (32%), Positives = 101/194 (51%), Gaps = 16/194 (8%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDG---YEVFGTSRKGAQPNT---------NYSFKMVEL 52
+ VLI+G SSGIGL++A +L D Y+V T R + T + + +L
Sbjct: 6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQL 65
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
DV D SVA ++ + G++DVL+NNAG+G+ E S+ + +FDTN FG +R+
Sbjct: 66 DVCSDESVAQCLSCIQ---GEVDVLVNNAGMGLV-GPLEGLSLAAMQNVFDTNFFGAVRL 121
Query: 113 TQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVS 172
+AVLP M+ + V F +Y+ASK ALE + E+L ++ I +S
Sbjct: 122 VKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFIS 181
Query: 173 VIDPHLIKTPMFSK 186
+++P + T K
Sbjct: 182 LVEPGPVVTEFEGK 195
>Hs20149619 [Q] KOG1205 Predicted dehydrogenase
Length = 325
Score = 93.6 bits (231), Expect = 3e-19
Identities = 56/192 (29%), Positives = 100/192 (51%), Gaps = 15/192 (7%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGA-------QPNTNYSFK-------M 49
N VV+ITGA+SG+G + A+ G ++ R G + +++ K +
Sbjct: 52 NAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYL 111
Query: 50 VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGV 109
V D+T G++ A AE+++ G +D+L+NNAG+ +++++ K + +TN FG
Sbjct: 112 VTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYR-GTIMDTTVDVDKRVMETNYFGP 170
Query: 110 MRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGI 169
+ +T+A+LP M ++ + + F + Y+ASKHA +A+ + L E+ I
Sbjct: 171 VALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEI 230
Query: 170 RVSVIDPHLIKT 181
V+VI P I T
Sbjct: 231 EVTVISPGYIHT 242
>Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 93.6 bits (231), Expect = 3e-19
Identities = 73/282 (25%), Positives = 130/282 (45%), Gaps = 23/282 (8%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGT--SRKGAQP---NTNYSFKMVELDVTKDG 58
+K V ITG SG G +A +L G V + KGA+ T+ + V LDVTK
Sbjct: 29 DKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKME 88
Query: 59 SVATAVAEVMKNAGKIDV--LINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
S+A A V ++ G + L+NNAG+ E + E S + NL GV+++T ++
Sbjct: 89 SIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSM 148
Query: 117 LPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDP 176
LP +R G Y SK+ +EA+++ L E+++ G+++S+++P
Sbjct: 149 LPLVRRARGRIVNVSSILGRVAFFVGG--YCVSKYGVEAFSDILRREIQHFGVKISIVEP 206
Query: 177 HLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQ-------------LESAEETSVVTD 223
+T M + +R + E K + + +Q L + ++VTD
Sbjct: 207 GYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTD 266
Query: 224 TVLYSLQQTAPHIRYTPGRAKRFAYFRY-YAPSAIFDRVIQK 264
+ ++L P RY+ G +F + Y P+++ D ++ +
Sbjct: 267 CMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTR 308
>HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 92.4 bits (228), Expect = 6e-19
Identities = 81/283 (28%), Positives = 135/283 (47%), Gaps = 29/283 (10%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGT--SRKGAQP---NTNYSFKMVELDVTKDG 58
+K V ITG SG G +A +L G V + KGA+ T+ + V LDVTK
Sbjct: 29 DKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTE 88
Query: 59 SVATA---VAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
SVA A V E +++ G + L+NNAG+ + A E + + I D NL GV+ +T +
Sbjct: 89 SVAAAAQWVKECVRDKG-LWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLS 147
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVID 175
+LP +R+ FG Y SK+ +EA++++L E+ G++V++I+
Sbjct: 148 LLPLVRKARGRVVNVSSVMGRVS--LFGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIE 205
Query: 176 PHLIKTPMFSKDLEPDRPLSIYSETR---------------KRLATSMEKQLESAEETSV 220
P KT + SK+ L I+ + K+ A ME+ + ++ S+
Sbjct: 206 PGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQ--KCTQDLSL 263
Query: 221 VTDTVLYSLQQTAPHIRYTPGRAKRFAYF-RYYAPSAIFDRVI 262
VT+ + ++L P RY+ G + Y Y P+ + D ++
Sbjct: 264 VTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306
>7290108 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 91.3 bits (225), Expect = 1e-18
Identities = 65/180 (36%), Positives = 95/180 (52%), Gaps = 10/180 (5%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ-PNTNYSFK-----MVELDVTK 56
SNKVV++TGASSGIG IA+ L +G + R A T S K +V DVTK
Sbjct: 4 SNKVVIVTGASSGIGAAIAQVLAREGATLALVGRNVANLEATKKSLKGTQAEIVVADVTK 63
Query: 57 DGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
D V + + G+IDVL+NNAG+ + + IE+ + +TNL GV+ +T+AV
Sbjct: 64 DAD--AIVQQTLAKFGRIDVLVNNAGI-LGKGGLIDLDIEEFDAVLNTNLRGVILLTKAV 120
Query: 117 LPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDP 176
LPH+ + P A Y SK AL+ +T+ + E+ QG+RV+ ++P
Sbjct: 121 LPHLLKTKGAVVNVSSCAGIR-PFAGALSYGVSKAALDQFTKIVALEMAPQGVRVNSVNP 179
>YMR226c [Q] KOG1205 Predicted dehydrogenase
Length = 267
Score = 90.9 bits (224), Expect = 2e-18
Identities = 67/251 (26%), Positives = 118/251 (46%), Gaps = 18/251 (7%)
Query: 3 SNKVVLITGASSGIG----LDIAEKLQLDGYEVFGTSRKGA---------QPNTNYSFKM 49
+ K VLITGAS+GIG L+ E D + R Q N +
Sbjct: 12 AKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHV 71
Query: 50 VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGV 109
+LD+T+ + + + + ID+L+NNAG + + + E + +FDTN+ +
Sbjct: 72 AQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTAL 131
Query: 110 MRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGI 169
+ +TQAVLP + + G+IY ASK A+ A+T++L E+ N I
Sbjct: 132 INITQAVLPIFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKELINTKI 191
Query: 170 RVSVIDPHLIKT--PMFSKDLEPDRPLSIYSETRKRLATSMEKQL---ESAEETSVVTDT 224
RV +I P L++T + ++ ++Y +T +A + + S ++ +V+ DT
Sbjct: 192 RVILIAPGLVETEFSLVRYRGNEEQAKNVYKDTTPLMADDVADLIVYATSRKQNTVIADT 251
Query: 225 VLYSLQQTAPH 235
+++ Q +PH
Sbjct: 252 LIFPTNQASPH 262
>7301818 [Q] KOG1205 Predicted dehydrogenase
Length = 326
Score = 90.9 bits (224), Expect = 2e-18
Identities = 71/266 (26%), Positives = 119/266 (44%), Gaps = 23/266 (8%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ------------PNTNYSFKMVEL 52
KVVLITGASSG+G +A G V +R+ + + Y ++ L
Sbjct: 54 KVVLITGASSGLGESLAHVFYRAGCRVILAARRTQELERVKKDLLALDVDPAYPPTVLPL 113
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
D+ + S+ V V+ ++D+LINN G+ + A ++++ + N FG + +
Sbjct: 114 DLAELNSIPEFVTRVLAVYNQVDILINNGGISVR-ADVASTAVDVDLKVMVVNYFGSVAL 172
Query: 113 TQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVS 172
T+A+LP M ++ + A YSASKHA++A+ ++L EV N+ I VS
Sbjct: 173 TKALLPSMVKRGSGHICFISSVQGKFAIPQRAAYSASKHAMQAFADSLRAEVANKNINVS 232
Query: 173 VIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDTVLYSLQQT 232
+ P I+T + L S Y + + A M + + +L + +
Sbjct: 233 CVSPGYIRTQLSLNALTGSG--SSYGKVDETTAKGM--------SPDKLAERILQCILRK 282
Query: 233 APHIRYTPGRAKRFAYFRYYAPSAIF 258
P I + +AK Y R+ PS F
Sbjct: 283 EPDIIVSDVQAKIAYYLRHLCPSLYF 308
>Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 90.5 bits (223), Expect = 2e-18
Identities = 81/283 (28%), Positives = 133/283 (46%), Gaps = 29/283 (10%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGT--SRKGAQP---NTNYSFKMVELDVTKDG 58
+K V ITG SG G +A +L G V + KGA+ T+ + V LDVTK
Sbjct: 29 DKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTE 88
Query: 59 SVATA---VAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
SVA A V E +++ G + L+NNAG+ + A E + + I D NL GV+ +T
Sbjct: 89 SVAAAAQWVKECVRDKG-LWGLVNNAGISLPTAPNELLTKQDLLTILDVNLLGVIDVTLN 147
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVID 175
+LP +R FG Y SK+ +EA++++L E+ G++V++I+
Sbjct: 148 LLPLVRRARGRVVNVFSVMGRVS--LFGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIE 205
Query: 176 PHLIKTPMFSKDLEPDRPLSIYSETR---------------KRLATSMEKQLESAEETSV 220
P KT + SK+ L I+ + K+ A ME+ + ++ S+
Sbjct: 206 PGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQ--KCTQDLSL 263
Query: 221 VTDTVLYSLQQTAPHIRYTPGRAKRFAYF-RYYAPSAIFDRVI 262
VT+ + ++L P RY+ G + Y Y P+ + D ++
Sbjct: 264 VTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIM 306
>SPAC977.08 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 89.7 bits (221), Expect = 4e-18
Identities = 50/193 (25%), Positives = 99/193 (50%), Gaps = 2/193 (1%)
Query: 49 MVELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFG 108
+ +LDV S+ +V + + + G+IDVL+NNAG + ++ E ++ EQ IF+TN+FG
Sbjct: 18 VTQLDVNNFSSIKKSVEKAISHFGRIDVLLNNAGYSV-YSPLESTTEEQIHNIFNTNVFG 76
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
+ + +A+ P R Q + G +Y +K+A+E +EAL E+++ G
Sbjct: 77 ALEVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIG 136
Query: 169 IRVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDTVLYS 228
++V +I+P T F + + + Y +++L + +L++A + + +L +
Sbjct: 137 VKVKIIEPGFTATE-FRVEEGAGKHYAEYDNLKQKLYEDLLPKLKTATPPQKIAEVILQA 195
Query: 229 LQQTAPHIRYTPG 241
+ +RY G
Sbjct: 196 ATDESDELRYPTG 208
>SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 296
Score = 89.7 bits (221), Expect = 4e-18
Identities = 69/192 (35%), Positives = 98/192 (50%), Gaps = 6/192 (3%)
Query: 1 MSSNKVVLITGASSG-IGLDIAEKLQLDGYEVFGTSRKGAQPN--TNYSFKMVELDVTKD 57
M + K VLITG S G IG +A K +G++V T+R+ + + T + ++LDVT +
Sbjct: 1 MEAEKFVLITGCSEGGIGNALALKFHQEGFQVLATARQVERMDNLTKAGLQTLKLDVTDE 60
Query: 58 GSVATAVAEVMK-NAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
SV EV K G + LINNAG S A A + IE + D N +GV+RM +A
Sbjct: 61 DSVREVEQEVRKFTNGSLHYLINNAGAPCS-APAIDLDIEDVSKVMDVNFYGVIRMNKA- 118
Query: 117 LPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDP 176
H + VP AF A Y+ASK AL AY+ L E+ G++V+ I
Sbjct: 119 FQHQLIRAKGTIVNVNSLVSYVPFAFNAAYNASKAALLAYSNTLRIELAPFGVQVTSIMT 178
Query: 177 HLIKTPMFSKDL 188
++T + SK L
Sbjct: 179 GGVQTKIQSKPL 190
>SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 89.7 bits (221), Expect = 4e-18
Identities = 50/193 (25%), Positives = 99/193 (50%), Gaps = 2/193 (1%)
Query: 49 MVELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFG 108
+ +LDV S+ +V + + + G+IDVL+NNAG + ++ E ++ EQ IF+TN+FG
Sbjct: 18 VTQLDVNNFSSIKKSVEKAISHFGRIDVLLNNAGYSV-YSPLESTTEEQIHNIFNTNVFG 76
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
+ + +A+ P R Q + G +Y +K+A+E +EAL E+++ G
Sbjct: 77 ALEVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQSIG 136
Query: 169 IRVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDTVLYS 228
++V +I+P T F + + + Y +++L + +L++A + + +L +
Sbjct: 137 VKVKIIEPGFTATE-FRVEEGAGKHYAEYDNLKQKLYEDLLPKLKTATPPQKIAEVILQA 195
Query: 229 LQQTAPHIRYTPG 241
+ +RY G
Sbjct: 196 ATDESDELRYPTG 208
>Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 313
Score = 89.0 bits (219), Expect = 6e-18
Identities = 74/285 (25%), Positives = 130/285 (44%), Gaps = 23/285 (8%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGT--SRKGAQP---NTNYSFKMVELDVTKD 57
S K V ITG SG G +A++L G +V + +G+Q +T+Y + LDVTK
Sbjct: 24 SEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSYRLQTTLLDVTKS 83
Query: 58 GSVATAVAEVMKNAGK--IDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
S+ A V G+ + L+NNAGVG+ E + + + + NL G++ +T
Sbjct: 84 ESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVGLIEVTLH 143
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVID 175
+LP ++ + G Y SK +EA+++++ E+ G++V +I+
Sbjct: 144 MLPMVKRARGRVVNMSSSGGRVAVIGGG--YCVSKFGVEAFSDSIRRELYYFGVKVCIIE 201
Query: 176 PHLIKTPMFSKD-LE----------PDRPLSIYSETRKRLATSMEKQLESAEETSV--VT 222
P +T + K+ LE P Y E R+ T K + E V V
Sbjct: 202 PGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQVAEPRVRDVI 261
Query: 223 DTVLYSLQQTAPHIRYTPGRAKRFAYFRY-YAPSAIFDRVIQKFL 266
+++ +++ +P IRY PG + Y P+ + D ++ ++L
Sbjct: 262 NSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDFILSRYL 306
>At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 299
Score = 88.2 bits (217), Expect = 1e-17
Identities = 82/278 (29%), Positives = 123/278 (43%), Gaps = 31/278 (11%)
Query: 6 VVLITGASSG-IGLDIAEKLQLDGYEVFGTSR-KGAQPNTNYSFKMV--ELDVTKDGSVA 61
VVLITG S G IG +A + G V TSR + + ++ ELDV D +V+
Sbjct: 9 VVLITGCSQGGIGHALAREFTEKGCRVVATSRSRSTMTDLEQDSRLFVKELDVQSDQNVS 68
Query: 62 TAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFG------------- 108
++EV+ GKIDVL+NNAGV AE + I + F+TN+FG
Sbjct: 69 KVLSEVIDKFGKIDVLVNNAGVQCVGPLAE-TPISAMENTFNTNVFGNKDLIFSFNYYIY 127
Query: 109 -------VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALD 161
MRMTQAV+PHM + P + +Y+A+K A+ A T+ L
Sbjct: 128 WSFNSSGSMRMTQAVVPHMVSKKKGKIVNVGSITVMAPGPWAGVYTATKAAIHALTDTLR 187
Query: 162 HEVRNQGIRVSVIDPHLIKTPMFSKDLE-----PDRPLSIYSETRKRLATSMEKQLESAE 216
E+R GI V + P I+T + + + P+ L E R + +++
Sbjct: 188 LELRPFGIDVINVVPGGIRTNIANSAVATFNKMPELKLYKPYEEAIRERAFISQRMNPTP 247
Query: 217 ETSVVTDTVLYSLQQTAPHIRYTPGRAKRFAYFRYYAP 254
+ DTV L++ P ++ GR Y+ P
Sbjct: 248 AETFARDTVAAVLKKNPP-AWFSSGRYSTLMAVMYHMP 284
>At3g03330 [Q] KOG1205 Predicted dehydrogenase
Length = 345
Score = 82.0 bits (201), Expect = 8e-16
Identities = 63/191 (32%), Positives = 88/191 (45%), Gaps = 15/191 (7%)
Query: 5 KVVLITGASSGIGLDIAEKL-QLDGYEVFGTSRKGAQPNTNYSFK---------MVELDV 54
KVV ITGAS GIG +A++ LD + K K ++ LD+
Sbjct: 44 KVVWITGASRGIGEILAKQFASLDAKLILSARNKAELDRVKSELKGKFAPEDVKVLPLDL 103
Query: 55 TKDGSVATAVAE----VMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVM 110
V E + AG +D L++NA + A ++S E K FD N+FG +
Sbjct: 104 ASGEESLKHVVEQAVSLFPGAG-VDYLVHNAAFERPKSKASDASEETLKTTFDVNVFGTI 162
Query: 111 RMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIR 170
+T+ V PHM +Q VP AIYSASKHAL Y +L E +GI+
Sbjct: 163 SLTKLVAPHMLKQGGGHFVVISSAAGKVPSPGQAIYSASKHALHGYFHSLRSEFCQKGIK 222
Query: 171 VSVIDPHLIKT 181
V+V+ P I+T
Sbjct: 223 VTVVCPGPIET 233
>Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 405
Score = 80.9 bits (198), Expect = 2e-15
Identities = 70/294 (23%), Positives = 119/294 (39%), Gaps = 39/294 (13%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNT-------NYSFKMVELDVT 55
+ + VLITG SG G + A+KL G+ V T + P + +++++D+T
Sbjct: 81 ATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLT 140
Query: 56 KDGSVATAVAEVMKNAGKIDV--LINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
K G ++ + + + L+NNAG A AE S + + + N FG + +T
Sbjct: 141 KPGDISRLLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELT 200
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
+ +LP +R GA Y SK A+ + E+ G++VS+
Sbjct: 201 KGLLPLLRSSRGRIVTVGSPAGDMPYPCLGA-YGTSKAAVALLMDTFSCELLPWGVKVSI 259
Query: 174 IDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESA------------------ 215
I P KT E R + + + ++ L ++ ++L A
Sbjct: 260 IQPGCFKT-------ESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLR 312
Query: 216 ---EETSVVTDTVLYSLQQTAPHIRYTPGRAKRFAYF-RYYAPSAIFDRVIQKF 265
+ + V D + +L P RY PG+ YF YY P + R +Q F
Sbjct: 313 LAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAF 366
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 80.1 bits (196), Expect = 3e-15
Identities = 68/248 (27%), Positives = 113/248 (45%), Gaps = 16/248 (6%)
Query: 5 KVVLITGASSGIG----LDIAE----KLQLDGYEVFGTSRKGAQPNTNYSFKMV--ELDV 54
K +LITGASSGIG +IA+ KL L + + Y ++ +LDV
Sbjct: 7 KTILITGASSGIGKSTAFEIAKVAKVKLILAARRFSTVEEIAKELESKYEVSVLPLKLDV 66
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
+ S+ + + K IDVLINNAG+ + + +I+ + + TN+ G+M MT+
Sbjct: 67 SDLKSIPGVIESLPKEFADIDVLINNAGLALGTDKVIDLNIDDAVTMITTNVLGMMAMTR 126
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVI 174
AVLP + G++Y ++K AL +T AL E + IR+ +
Sbjct: 127 AVLPIFYSKNKGDILNVGSIAGRESYVGGSVYCSTKSALAQFTSALRKETIDTRIRIMEV 186
Query: 175 DPHLIKTPMFSKDLEPDRPL--SIYSETRKRLATSMEKQLESA---EETSVVTDTVLY-S 228
DP L++T D+ ++Y + + + + A E V+ DT+++ S
Sbjct: 187 DPGLVETEFSVVRFHGDKQKADNVYKNSEPLTPEDIAEVILFALTRRENVVIADTLVFPS 246
Query: 229 LQQTAPHI 236
Q A H+
Sbjct: 247 HQGGANHV 254
>CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 388
Score = 79.3 bits (194), Expect = 5e-15
Identities = 76/294 (25%), Positives = 126/294 (42%), Gaps = 34/294 (11%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFG---TSRKGAQPNTNYSFKM--------V 50
SS K V+ITG SG G +A L VF T + A ++ + K +
Sbjct: 30 SSGKYVMITGCDSGFGRLLATSLLDKHVNVFAACFTQQGMASLHSEWKLKKGPKGQLYTL 89
Query: 51 ELDVTKDGSVATA---VAEVMKNAG-KIDVLINNAGVGISWAAAEESSIEQSKFIFDTNL 106
+LDVT SV +A V +++K K+ L+NNAG+ + S+++ + N
Sbjct: 90 QLDVTSQASVDSAKSFVTKILKEQNSKLWGLVNNAGIFSIHGPDDWCSVDEYASSLNVNT 149
Query: 107 FGVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRN 166
G +RM A +P +++ + + A Y +K A+EAY + L E+R
Sbjct: 150 LGAVRMCHAFVPLIKKSRGRIVTMGSTAGRLHGL-YVAPYVTAKFAVEAYMDCLRLEMRP 208
Query: 167 QGIRVSVIDPHLIKTPMFSKDLEPDRPLSIYS----ETRKRLATSMEKQLESAEETSV-- 220
G+ V +++P KT + + D + R I++ ET++ E A E V
Sbjct: 209 FGVSVHILEPGCFKTELLNNDAQRMRIQKIWNSLSVETKEEYGEDYRNDFERAWEAGVNV 268
Query: 221 --------VTDTVLYSLQQTAPHIRYTPGRAKRFAYFRYYAPSAIFDRVIQKFL 266
V D ++L P +RY PG F + P +IF +Q ++
Sbjct: 269 VANPNIGWVVDCYSHALFSWWPRLRYCPGWDAIFMFI----PLSIFPTALQDWI 318
>Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase
Length = 244
Score = 78.6 bits (192), Expect = 9e-15
Identities = 71/241 (29%), Positives = 109/241 (44%), Gaps = 23/241 (9%)
Query: 6 VVLITGASSGIGLDIAEKLQLD---GYEVFGTSRKGAQPNTNY-----------SFKMVE 51
VVLITG SSGIGL +A +L D ++V+ T R + S + ++
Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
LDV SVA A V + G++DVL+ NAG+G+ E + + D N+ G +R
Sbjct: 65 LDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLL-GPLEALGEDAVASVLDVNVVGTVR 121
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRV 171
M QA LP M+ + + + F +Y ASK ALE E+L + G+ +
Sbjct: 122 MLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHL 181
Query: 172 SVIDPHLIKTPMFSKDL-EPDRPLS-----IYSETRKRLATSMEKQLESAEETSVVTDTV 225
S+I+ + T K L P+ L + + LA S + E+A+ V +
Sbjct: 182 SLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVF 241
Query: 226 L 226
L
Sbjct: 242 L 242
>Hs7706318 [Q] KOG1205 Predicted dehydrogenase
Length = 339
Score = 78.2 bits (191), Expect = 1e-14
Identities = 61/201 (30%), Positives = 101/201 (49%), Gaps = 18/201 (8%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ---------PNTNYSFK---MV 50
++ VV +TGASSGIG ++A +L G + ++R+ + N N K ++
Sbjct: 49 TDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVL 108
Query: 51 ELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVM 110
LD+T GS A V++ G+ID+L+NN G+ + ++S++ + + + N G +
Sbjct: 109 PLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMS-QRSLCMDTSLDVYRKLIELNYLGTV 167
Query: 111 RMTQAVLPHM--REQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRN-Q 167
+T+ VLPHM R+Q VP++ G Y ASKHAL + L E+
Sbjct: 168 SLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIG--YCASKHALRGFFNGLRTELATYP 225
Query: 168 GIRVSVIDPHLIKTPMFSKDL 188
GI VS I P +++ + L
Sbjct: 226 GIIVSNICPGPVQSNIVENSL 246
>CE06649 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 77.4 bits (189), Expect = 2e-14
Identities = 55/202 (27%), Positives = 95/202 (46%), Gaps = 21/202 (10%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK--------------GAQPNTNYSFK 48
S KVVLI+G+S GIG A K +G ++ R GA+P +
Sbjct: 7 SGKVVLISGSSKGIGQATAVKFAAEGAKIVLNGRSADDVEKTRKLCMEVGAKP---WDLL 63
Query: 49 MVELDVTKDGSVATAVAEVMKNAGKIDVLINNAG---VGISWAAAEESSIEQSKFIFDTN 105
D+T + V V V+ N GK+D+LINNAG V ++ E ++ +++N
Sbjct: 64 PTVGDITNEDFVKMMVNTVIHNFGKLDILINNAGTLEVDMTGKEGWEMGVDVMDRSWNSN 123
Query: 106 LFGVMRMTQAVLPHM-REQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEV 164
V+ +TQA +PH+ + + + V Y+ K AL+ + ++ HE
Sbjct: 124 FKSVLMLTQAAMPHLIKTKGDIVNVSTFLSSGPIGVMSMPYYAVPKAALDQMSRSMAHEY 183
Query: 165 RNQGIRVSVIDPHLIKTPMFSK 186
+G+R++ ++P L+ T F++
Sbjct: 184 MLKGVRLNTVNPGLVSTSFFAR 205
>At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 331
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/195 (32%), Positives = 91/195 (46%), Gaps = 17/195 (8%)
Query: 7 VLITGASSGIGLDIAEKLQLDGYEV---------FGTSRKGAQPNTNYSFKMVELDVTKD 57
V ITG SSGIGL +A + +G +V +++ Q T DV
Sbjct: 40 VFITGGSSGIGLALAHRAVSEGAKVSILARSTEKLAEAKRSIQLATGVEVATFSADVRDY 99
Query: 58 GSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVL 117
+V+ A+ E +G IDVLI N GV I E+ S E+ KF+ D NL G + +A L
Sbjct: 100 DAVSKAIDE----SGPIDVLIVNQGVFIG-KELEKQSPEEVKFMIDVNLTGSFNVIKAAL 154
Query: 118 PHMREQXXXXXXXXXXXXXXVPVA--FG-AIYSASKHALEAYTEALDHEVRNQGIRVSVI 174
P M+ + A +G YSASK L+ +AL EV + GI V+++
Sbjct: 155 PAMKAREGRGPASISLVSSQAGQAGIYGYTAYSASKFGLQGLAQALQQEVISDGIHVTLL 214
Query: 175 DPHLIKTPMFSKDLE 189
P TP F ++L+
Sbjct: 215 FPPDTDTPGFEQELK 229
>Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 343
Score = 77.0 bits (188), Expect = 3e-14
Identities = 68/266 (25%), Positives = 124/266 (46%), Gaps = 32/266 (12%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFG---------TSRKGAQPNTNYSFKMVELDV 54
+K VL+TG SG G +A+ L G+ VF K + + V+L+V
Sbjct: 55 SKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNV 114
Query: 55 TKDGSVATAVAEVMKNAGK-----IDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGV 109
V V E+++++ K + L+NNAG+ ++ E +S+E K + + NL+G
Sbjct: 115 CSSEEV-EKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLWGT 172
Query: 110 MRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGI 169
+RMT++ LP +R A + Y +K +EA+++ L +E+ G+
Sbjct: 173 VRMTKSFLPLIRRAKGRVVNISSMLGRMANPA-RSPYCITKFGVEAFSDCLRYEMYPLGV 231
Query: 170 RVSVIDP--HLIKTPMFS--------KDLEPDRPLSIYSETRKRLATSMEKQLES----- 214
+VSV++P + T ++S K + + P + + K+ ++E+
Sbjct: 232 KVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSG 291
Query: 215 AEETSVVTDTVLYSLQQTAPHIRYTP 240
+ +TS V D V ++L T P+ RY P
Sbjct: 292 STDTSPVIDAVTHALTATTPYTRYHP 317
>CE03954 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 274
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/211 (27%), Positives = 94/211 (44%), Gaps = 16/211 (7%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ-PNTNYSFKMVELDVTKDGSVA 61
++KV +ITG+S+GIG A L DG +V T R A+ T + + T SV
Sbjct: 5 TDKVAIITGSSNGIGRATAVLLATDGAKVTITGRDAARLEETRQAILKAGISATNVNSVV 64
Query: 62 T----------AVAEVMKNAGKIDVLINNAGVGISWAAAE---ESSIEQSKFIFDTNLFG 108
++ + GKI++LINNAG I + + + SIE +F NL
Sbjct: 65 ADVTTAEGQDLLISSTLDKFGKINILINNAGANIPDSQGQTRTKCSIENLTKMFQLNLQS 124
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
V+ M Q V PH+ + YS++K AL+ Y+ ++ ++G
Sbjct: 125 VVEMVQKVRPHLAKTRGEIVNISSIGAGPAAQPASPYYSSAKAALDQYSRCAAIDLISEG 184
Query: 169 IRVSVIDPHLIKT--PMFSKDLEPDRPLSIY 197
IR++V+ P + T ++ L D + Y
Sbjct: 185 IRINVVQPGFVSTGFSTAARGLSADESVKFY 215
>SPCC162.03 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 76.3 bits (186), Expect = 4e-14
Identities = 58/203 (28%), Positives = 97/203 (47%), Gaps = 4/203 (1%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKM-VELDVTKDGSV 60
S+ VLITG+S G+G + + GY V SR +S + ++LDVT SV
Sbjct: 3 STFSTVLITGSSKGLGYALVKVGLAQGYNVIACSRAPDTITIEHSKLLKLKLDVTDVKSV 62
Query: 61 ATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLPHM 120
TA + + G +D++INNAG G+ E +IE+ + N +GV +T+ L M
Sbjct: 63 ETAFKDAKRRFGNVDIVINNAGYGLV-GEFESYNIEEMHRQMNVNFWGVAYITKEALNLM 121
Query: 121 REQ-XXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEV-RNQGIRVSVIDPHL 178
RE P ++Y+ASK A+E ++ + E+ N I ++++ P
Sbjct: 122 RESGKGGRILQISSVAGYYPSPCLSMYNASKFAVEGLSQTIMRELDPNWNIAITIVQPGG 181
Query: 179 IKTPMFSKDLEPDRPLSIYSETR 201
++T S +++ +P Y R
Sbjct: 182 MQTEWASSNMQWAKPHPAYENDR 204
>YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 297
Score = 75.9 bits (185), Expect = 6e-14
Identities = 67/223 (30%), Positives = 107/223 (47%), Gaps = 26/223 (11%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNT-------NYSFKMVELDVTKD 57
K+ ++TGAS GIG ++ ++L +GY V+ +R+ +P N S K +LD++K
Sbjct: 10 KIAVVTGASGGIGYEVTKELARNGYLVYACARR-LEPMAQLAIQFGNDSIKPYKLDISKP 68
Query: 58 GSVATAVAEVMKNA--GKIDVLINNAGVGISWAA--AEESSIEQSKFIFDTNLFGVMRMT 113
+ T + N GK+D+L NNAG ++ A A ++++EQ F N+FG + M
Sbjct: 69 EEIVTFSGFLRANLPDGKLDLLYNNAGQSCTFPALDATDAAVEQ---CFKVNVFGHINMC 125
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRV-S 172
+ L + V FG+IYSASK A+ Y L E++ +RV +
Sbjct: 126 RE-LSEFLIKAKGTIVFTGSLAGVVSFPFGSIYSASKAAIHQYARGLHLEMKPFNVRVIN 184
Query: 173 VIDPHLIKTPMFSKDLEPDRPL---SIYSETRKRLATSMEKQL 212
I T + D+ RPL SIY+ R A + K +
Sbjct: 185 AI------TGGVATDIADKRPLPETSIYNFPEGREAFNSRKTM 221
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 75.5 bits (184), Expect = 7e-14
Identities = 53/193 (27%), Positives = 85/193 (43%), Gaps = 14/193 (7%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKM-----------VE 51
++KV +ITG+S+GIG A L +G +V T R + + + V
Sbjct: 5 TDKVAIITGSSNGIGQATARLLASEGAKVTVTGRNAERLEETKNILLGAGVPEGNVLVVV 64
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAE---ESSIEQSKFIFDTNLFG 108
D+T++ + + GKID+L+NNAG GI A + SI+ F+ N+
Sbjct: 65 GDITQESVQENLIKSTLDKFGKIDILVNNAGAGIPDAQGKSGVNQSIDTYHKTFELNVQS 124
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
V+ MTQ PH+ + YS +K AL+ YT ++ +G
Sbjct: 125 VIEMTQKARPHLAKTQGEIVNISSIGAGPAAQVASPYYSIAKAALDQYTRTAAIDLVPEG 184
Query: 169 IRVSVIDPHLIKT 181
IRV+ + P + T
Sbjct: 185 IRVNSVSPGAVST 197
>7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 242
Score = 75.1 bits (183), Expect = 1e-13
Identities = 57/184 (30%), Positives = 93/184 (49%), Gaps = 8/184 (4%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELD-VTKDGSVA 61
+ KV+L+TGA +GIG + ++L G V +RK Q +F V + + D S
Sbjct: 6 AGKVILVTGAGAGIGQALVKQLASAGATVIAVARKPEQLQQLVAFDPVHIQPLQLDLSGW 65
Query: 62 TAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLPHMR 121
AV E + +D L+NNAGV I EE + + FD N+ V +TQ++LP ++
Sbjct: 66 QAVREGLAKVPLLDGLVNNAGVAII-KPFEELTEQDFDTHFDVNIKAVFNVTQSLLPRLK 124
Query: 122 EQXXXXXXXXXXXXXXVPVAFG--AIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHLI 179
+ +FG YSA+K AL++ T++L E+ + IRV+ ++P ++
Sbjct: 125 DGASIVNVSSIASSR----SFGGHTAYSATKAALDSLTKSLALELGPRKIRVNSVNPTVV 180
Query: 180 KTPM 183
T M
Sbjct: 181 LTKM 184
>CE03132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 74.3 bits (181), Expect = 2e-13
Identities = 52/193 (26%), Positives = 88/193 (44%), Gaps = 14/193 (7%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNY-----------SFKMVE 51
S KV +ITG+SSGIG + A +G +V T R + +F +V
Sbjct: 6 SKKVAIITGSSSGIGRETALLFAKEGAKVTVTGRSEEKLEETKKALLDAGIKESNFLIVP 65
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAE---ESSIEQSKFIFDTNLFG 108
D+T +++ +K G+I++L+NNAG I A + IE + + N+
Sbjct: 66 ADITFSTGQDELISQTLKKFGRINILVNNAGASIPDAKKRTGIDQGIETYEQVMKLNVQS 125
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
V+ MTQ V PH+ + Y +K AL+ YT + + ++G
Sbjct: 126 VIEMTQKVRPHLAKSRGEIVNVSSVVALKAGWTRTPYYPLAKAALDQYTRSAAIALISEG 185
Query: 169 IRVSVIDPHLIKT 181
IRV+ ++P +++T
Sbjct: 186 IRVNTVNPGIVQT 198
>Hs7705907 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 73.6 bits (179), Expect = 3e-13
Identities = 58/204 (28%), Positives = 94/204 (45%), Gaps = 15/204 (7%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVF--------GTSRKGAQPNTNYSFKMVELDV 54
+ KVV++TG GIG I G V G + + P + + DV
Sbjct: 8 AGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVF----ILCDV 63
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
T++ V T V+E ++ G++D ++NNAG EE+S + + + + NL G +T+
Sbjct: 64 TQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTK 123
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVI 174
LP++R + + A Y A+K A+ A T+AL + G+RV+ I
Sbjct: 124 LALPYLR-KSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCI 182
Query: 175 DPHLIKTPMFSK--DLEPDRPLSI 196
P I TP++ + L PD SI
Sbjct: 183 SPGNIWTPLWEELAALMPDPRASI 206
>Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 319
Score = 72.8 bits (177), Expect = 5e-13
Identities = 69/283 (24%), Positives = 124/283 (43%), Gaps = 23/283 (8%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFG-----TSRKGAQPNTNYSFKMVELDVTKD 57
++K + ITG SG G A G+ V + + T+ + V LDVT
Sbjct: 28 TDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDP 87
Query: 58 GSVATAVAEVMKNAGKIDV--LINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
+V V G+ + LINNAGV A + ++E + + NLFG++ +T
Sbjct: 88 ENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLN 147
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVID 175
+LP +++ V G Y+ SK+A+E + ++L +++ G+ VS I+
Sbjct: 148 MLPLVKKAQGRVINVSSVGGRLAIVGGG--YTPSKYAVEGFNDSLRRDMKAFGVHVSCIE 205
Query: 176 PHLIKTPMFSKDLEPDRPLSIYSETRKRLATS-----MEKQLESAE--------ETSVVT 222
P L KT + ++ L+I+ + + +EK L+ + + S V
Sbjct: 206 PGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVV 265
Query: 223 DTVLYSLQQTAPHIRYTPGR-AKRFAYFRYYAPSAIFDRVIQK 264
+ + ++L P Y G+ AK F + P+A+ D ++ K
Sbjct: 266 ECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 308
>Hs10337605 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 72.8 bits (177), Expect = 5e-13
Identities = 63/200 (31%), Positives = 95/200 (47%), Gaps = 13/200 (6%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVE---LDVT---- 55
+NKV L+T ++ GIG IA +L DG V +SRK Q N + + ++ L VT
Sbjct: 13 ANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRK--QQNVDQAVATLQGEGLSVTGTVC 70
Query: 56 ---KDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
K VA +K G ID+L++NA V + + + + E D N+ M
Sbjct: 71 HVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALM 130
Query: 113 TQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVS 172
T+AV+P M ++ P + Y+ SK AL T+ L E+ + IRV+
Sbjct: 131 TKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVN 190
Query: 173 VIDPHLIKTPMFSKDLEPDR 192
+ P LIKT FS+ L D+
Sbjct: 191 CLAPGLIKT-SFSRMLWMDK 209
>CE03951 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 72.4 bits (176), Expect = 6e-13
Identities = 49/193 (25%), Positives = 90/193 (46%), Gaps = 14/193 (7%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPN-----------TNYSFKMVE 51
S KV +ITG+S GIG A +G +V T R + ++ +F +V
Sbjct: 6 SGKVAIITGSSFGIGRATALLFAKEGAKVTVTGRSEERLQGSKQALLDAGISDSNFLIVP 65
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWA---AAEESSIEQSKFIFDTNLFG 108
D+T +++ ++ G+I++L+NNAG I+ + A + I+ + + N+
Sbjct: 66 ADITTSSGQDALISKTLEKFGQINILVNNAGASIADSQNRAGLDQGIDTYEKVLKLNVQS 125
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
V+ MTQ + PH+ + Y +K AL+ YT + ++ +QG
Sbjct: 126 VIEMTQKIRPHLAKTRGEIVNVSSVAALKFAHVRNPYYPLAKAALDQYTRSAAIDLISQG 185
Query: 169 IRVSVIDPHLIKT 181
IRV+ ++P ++ T
Sbjct: 186 IRVNTVNPGVVAT 198
>At3g55310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 298
Score = 72.4 bits (176), Expect = 6e-13
Identities = 61/192 (31%), Positives = 90/192 (46%), Gaps = 14/192 (7%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPN-----------TNYSFKMVEL 52
+KVVL+TGASSGIG +I L G +V +R+ + N T +EL
Sbjct: 38 DKVVLVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQAAALEL 97
Query: 53 DVTKDGS-VATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
DV+ D + + AV E GKID LINNAG+ + + + S ++ +F+TNL G
Sbjct: 98 DVSSDAATIQKAVREAWDIFGKIDALINNAGIRGNVKLSLDLSEDEWDNVFNTNLKGPWL 157
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVP--VAFGAIYSASKHALEAYTEALDHEVRNQGI 169
+ + V MR+ V V G YS SK ++ + + E+ I
Sbjct: 158 VAKYVCVLMRDAKRGGSVINISSVAGVRSIVPGGLAYSCSKGGVDTMSRMMAIELGVHKI 217
Query: 170 RVSVIDPHLIKT 181
RV+ I P L K+
Sbjct: 218 RVNSIAPGLFKS 229
>At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 327
Score = 72.4 bits (176), Expect = 6e-13
Identities = 64/197 (32%), Positives = 88/197 (44%), Gaps = 18/197 (9%)
Query: 9 ITGASSGIGLDIAEKLQLDGYEVFGTSRKGA---------QPNTNYSFKMVELDVTKDGS 59
ITG SSGIGL +A + +G V +R G+ Q T DV +
Sbjct: 44 ITGGSSGIGLALAHRAASEGARVSILARSGSKLEEAKKSIQLATGVEVATFSADVRDYDA 103
Query: 60 VATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLPH 119
V+ A+ E +G IDVLI N GV + + S E KF D NL G + +A LP
Sbjct: 104 VSKAIDE----SGPIDVLIVNQGVFTAKELVKHSP-EDVKFTIDVNLVGSFNVIKAALPA 158
Query: 120 MR---EQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDP 176
M+ ++ V V A YSASK L+ +AL EV + I V++I P
Sbjct: 159 MKARKDRGPASISLVSSQAGQVGVYGYAAYSASKFGLQGLAQALQQEVISDDIHVTLIFP 218
Query: 177 HLIKTPMFSKDLEPDRP 193
TP F ++ + RP
Sbjct: 219 PDTNTPGFEEE-QKSRP 234
>At3g47360 [Q] KOG1205 Predicted dehydrogenase
Length = 309
Score = 72.0 bits (175), Expect = 8e-13
Identities = 57/194 (29%), Positives = 93/194 (47%), Gaps = 19/194 (9%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYE-------------VFGTSRKGAQPNTNYSFKM 49
+ KVVLITGASSGIG +A + G V TSR+ N +
Sbjct: 46 ARKVVLITGASSGIGEHVAYEYAKKGAYLALVARRRDRLEIVAETSRQLGSGNVI----I 101
Query: 50 VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGV 109
+ DV+ + E +++ GK+D LINNAGV + + + I+ + I D N +G
Sbjct: 102 IPGDVSNVEDCKKFIDETIRHFGKLDHLINNAGVFQTVLFEDFTQIQDANPIMDINFWGT 161
Query: 110 MRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGI 169
+T +PH+R + +P+ +IY+ASK AL + E L E+ + I
Sbjct: 162 TYITYFAIPHLR-KSKGKIVAITSGSANIPLPLASIYAASKAALLRFFETLRIEL-SPDI 219
Query: 170 RVSVIDPHLIKTPM 183
+++++ P ++ T M
Sbjct: 220 KITIVLPGVVSTDM 233
>Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 323
Score = 71.6 bits (174), Expect = 1e-12
Identities = 70/286 (24%), Positives = 125/286 (43%), Gaps = 25/286 (8%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFG-----TSRKGAQPNTNYSFKMVELDVTKD 57
++K + ITG SG G A G+ V + + T+ + V LDVT
Sbjct: 28 TDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDP 87
Query: 58 GSVATAVAEVMKNAGKIDV--LINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
+V V G+ + LINNAGV A + ++E + + NLFG++ +T
Sbjct: 88 ENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLN 147
Query: 116 VLPHMREQXXXXXXXXXXX---XXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVS 172
+LP +E +P + G Y+ SK+A+E + ++L +++ G+ VS
Sbjct: 148 MLPRPQEDQPGQGGTTLPSPCTAGKLP-SVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVS 206
Query: 173 VIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATS-----MEKQLESAE--------ETS 219
I+P L KT + ++ L+I+ + + +EK L+ + + S
Sbjct: 207 CIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLS 266
Query: 220 VVTDTVLYSLQQTAPHIRYTPGR-AKRFAYFRYYAPSAIFDRVIQK 264
V + + ++L P Y G+ AK F + P+A+ D ++ K
Sbjct: 267 PVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 312
>At3g47350 [Q] KOG1205 Predicted dehydrogenase
Length = 308
Score = 71.2 bits (173), Expect = 1e-12
Identities = 54/190 (28%), Positives = 92/190 (48%), Gaps = 11/190 (5%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKG---------AQPNTNYSFKMVELD 53
+ KVVLITGASSGIG +A + G ++ +R+ ++ + ++ D
Sbjct: 45 TGKVVLITGASSGIGEHVAYEYAKKGAKLALVARRKDRLEIVAETSRQLGSGDVIIIPGD 104
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
V+ + E + + GK+D LINNAGV + + + I+ + I D N +G +T
Sbjct: 105 VSNVEDCKKFIDETIHHFGKLDHLINNAGVPQTVIFEDFTQIQDANSIMDINFWGSTYIT 164
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
+PH+R + +P+ ++YSASK AL + E L E+ + I++++
Sbjct: 165 YFAIPHLR-KSKGKIVVISSATAIIPLQAASVYSASKAALVKFFETLRVEI-SPDIKITI 222
Query: 174 IDPHLIKTPM 183
P I T M
Sbjct: 223 ALPGFISTDM 232
>7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 336
Score = 70.9 bits (172), Expect = 2e-12
Identities = 58/200 (29%), Positives = 90/200 (45%), Gaps = 15/200 (7%)
Query: 7 VLITGASSGIGLDIAEKLQLDGYEVFGTSR-----KGA-------QPNTNYSFKMVELDV 54
V++TG S GIGL +A + + G V +R GA + + F+ LD+
Sbjct: 38 VVVTGGSKGIGLCLAVECAMKGANVTVIARDEKMLSGAVALMEVIRQRPDQKFQYRSLDI 97
Query: 55 TKD-GSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
+ D VA + E+ + G I LIN AG+ I EE S++ + + N FG T
Sbjct: 98 SGDYDQVAKVLGEIEDSFGPIYTLINCAGMAIC-GVFEEVSVQDVHKLMNVNFFGTYNCT 156
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
+ VLP M++ + YSA+K+AL A E + E R G+ V++
Sbjct: 157 RYVLPKMKKAGDGIIVITASQAAMFGIYGYGPYSATKYALRAMAETIAMESREHGVSVTL 216
Query: 174 IDPHLIKTPMFSKDLEPDRP 193
P TP F ++ E +P
Sbjct: 217 AMPCDTNTPGFEEE-EKSKP 235
>CE07539 [Q] KOG1205 Predicted dehydrogenase
Length = 537
Score = 70.1 bits (170), Expect = 3e-12
Identities = 58/213 (27%), Positives = 99/213 (46%), Gaps = 24/213 (11%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ------------PNTNYSFKMVE 51
NK+V+ITGASSG+G +A +L G +V +R + P
Sbjct: 78 NKIVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICAELTKTFPLNKNKPTYYF 137
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
D+T A K+DVLINNAG+ + + +++++ + +TNLFG ++
Sbjct: 138 FDITNPDKAPWA------QIPKVDVLINNAGMS-NRGSCQDTTMAIHRKAMETNLFGHVQ 190
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRV 171
+TQ++L + +P + YSASKHAL+ Y + L E +N + +
Sbjct: 191 VTQSLLSKLSPDGCIVVTSSIQGKVAIP--YRGSYSASKHALQGYFDCLRAEHKN--LHI 246
Query: 172 SVIDPHLIKTPMFSKDLEPD-RPLSIYSETRKR 203
V+ I T S+ L+ D + + + E +K+
Sbjct: 247 LVVSAGYINTGFGSRALDTDGKVVGVEDENQKK 279
>At2g29170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 70.1 bits (170), Expect = 3e-12
Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 20/196 (10%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVAEV 67
L+TG S G+G + E+L + G V +R Q + V K V T+V +V
Sbjct: 22 LVTGGSKGLGEAVVEELAMLGARVHTCARNETQLQ-----ECVREWQAKGFEVTTSVCDV 76
Query: 68 ---------MKNA-----GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
M+N GK+++L+NNAG GI+ E ++ + S F+ TNL ++
Sbjct: 77 SSRDQREKLMENVASIFQGKLNILVNNAGTGITKPTTEYTAQDYS-FLMATNLDSAFHLS 135
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
Q P ++ V + G+IY A+K A+ + L E IRV+
Sbjct: 136 QLAHPLLKASGSGSIVLMSSTAGVVHINVGSIYGATKGAMNQLAKNLACEWARDNIRVNS 195
Query: 174 IDPHLIKTPMFSKDLE 189
+ P I TP++ D E
Sbjct: 196 VCPWFIATPLYLNDEE 211
>CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 368
Score = 69.7 bits (169), Expect = 4e-12
Identities = 69/288 (23%), Positives = 120/288 (40%), Gaps = 30/288 (10%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFG--TSRKGAQPNTNYSFKMVE--------- 51
S + V ITG SG G +A K G VF + +G + + + K +
Sbjct: 68 SKRAVFITGCDSGFGRGLALKCLEQGMPVFAGCLTEQGIESLSAEARKSIGNGRSLDAFL 127
Query: 52 LDVTKD---GSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFG 108
+DVT D G VA + + + G + ++NNAG+ A + I + + + NL+G
Sbjct: 128 MDVTSDESVGEVAKRLEKKCEQYGGLHAVVNNAGITGKHIADDFLDINEYLKVANINLWG 187
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
+R T AV +++ G YS SK+ + AY + + E+R G
Sbjct: 188 PIRTTMAVKKLLKKARGRVVTVASICARVGLPGLGP-YSVSKYGVSAYCDVIRQELRPFG 246
Query: 169 IRVSVIDPHLIKTPMFSKD------LE-----PDRPLSIYSE---TRKRLATSMEKQLES 214
I V V++P TP+ +++ LE P+ Y E R +T + +
Sbjct: 247 ISVHVLEPGFFNTPLINREKIDAEILEAWKHAPNEVKQEYGEKFFNDARESTHLFLNSVA 306
Query: 215 AEETSVVTDTVLYSLQQTAPHIRYTPGRAKRFAYFRY-YAPSAIFDRV 261
+ + S+V D +++ P RY G + + Y P+ + D +
Sbjct: 307 SSQISLVVDAYFHAITSKHPRSRYQIGWDSILLFIPFSYLPTGLQDYI 354
>CE07544 [Q] KOG1205 Predicted dehydrogenase
Length = 262
Score = 69.7 bits (169), Expect = 4e-12
Identities = 58/214 (27%), Positives = 98/214 (45%), Gaps = 24/214 (11%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR------------KGAQPNTNYSFKMVE 51
NKVV+ITGASSG+G +A +L G +V +R K P
Sbjct: 47 NKVVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICEELKETFPLNQNEPIYYY 106
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
D+T A ++D+LINNAG+ + + +++++E + +TN FG +
Sbjct: 107 FDITDSEQAPWA------EIPRVDILINNAGMS-NRGSCQDTTMEIHRQAMETNYFGHVH 159
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRV 171
+TQA+L + +P + Y ASKHAL+ Y + L E +N + +
Sbjct: 160 VTQALLSKLSPDGCIVVTSSIQGKVAIP--YRGSYGASKHALQGYFDCLRAEHKN--LHI 215
Query: 172 SVIDPHLIKTPMFSKDLEPD-RPLSIYSETRKRL 204
V+ I T S+ L+P + + + E +K++
Sbjct: 216 LVVSAGYINTGFGSRALDPSGKVVGVEDENQKKV 249
>At5g06060 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 68.9 bits (167), Expect = 7e-12
Identities = 58/196 (29%), Positives = 89/196 (44%), Gaps = 10/196 (5%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYS-FKMVELDVTK---DG 58
+ K L+TG + GIG + E+L G +V SR + N + +K L V+ D
Sbjct: 10 AGKTALVTGGTRGIGRAVVEELAKFGAKVHTCSRNQEELNACLNDWKANGLVVSGSVCDA 69
Query: 59 SVATAVAEVMKNA-----GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
SV ++++ A GK+++LINN G + E SS E +K I TNL ++
Sbjct: 70 SVRDQREKLIQEASSAFSGKLNILINNVGTNVRKPTVEYSSEEYAK-IMSTNLESAFHLS 128
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
Q P ++ V ++ G+IY A+K AL T L E + IR +
Sbjct: 129 QIAHPLLKASGVGSIVFISSVAGLVHLSSGSIYGATKGALNQLTRNLACEWASDNIRTNC 188
Query: 174 IDPHLIKTPMFSKDLE 189
+ P IKT + LE
Sbjct: 189 VAPWYIKTSLVETLLE 204
>At1g54870 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 68.6 bits (166), Expect = 9e-12
Identities = 60/216 (27%), Positives = 91/216 (41%), Gaps = 17/216 (7%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPN----TNYSFKMVELDVTK---- 56
+V LITG SGIG + +G V T KG + T K V+ +K
Sbjct: 36 RVALITGGDSGIGRAVGYCFASEGATVAFTYVKGQEEKDAQETLQMLKEVKTSDSKEPIA 95
Query: 57 -------DGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGV 109
D + V EV+ G+IDVLINNA + EE + + +F TN+F
Sbjct: 96 IPTDLGFDENCKRVVDEVVNAFGRIDVLINNAAEQYESSTIEEIDEPRLERVFRTNIFSY 155
Query: 110 MRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGI 169
+T+ L HM+E Y+A+K A+ A+T L ++ +GI
Sbjct: 156 FFLTRHALKHMKEGSSIINTTSVNAYKGNASLLD--YTATKGAIVAFTRGLALQLAEKGI 213
Query: 170 RVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLA 205
RV+ + P I TP+ ++ + SE + A
Sbjct: 214 RVNGVAPGPIWTPLIPASFNEEKIKNFGSEVPMKRA 249
>7297069 [Q] KOG1205 Predicted dehydrogenase
Length = 246
Score = 68.6 bits (166), Expect = 9e-12
Identities = 64/253 (25%), Positives = 111/253 (43%), Gaps = 39/253 (15%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ---------PNTNYSFKMVELDV 54
NK+ ++TGAS GIG A + G V G +R+ A+ +F DV
Sbjct: 6 NKLAVVTGASGGIGAACARAMIGAGLRVVGLARREAKLKELRESLPRELQANFIPRRCDV 65
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
+K+ V ++ + + DVL+NNAG+ S+ ++ K + DTN+ GV+ T+
Sbjct: 66 SKEDQVQSSFDWIERELEGADVLLNNAGITRETELVTPSNTQKLKEVIDTNVMGVIWCTR 125
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPV--------AFGAIYSASKHALEAYTEAL--DHEV 164
+M+ + V +F IY A+K A+ A TE + ++
Sbjct: 126 EAFNNMKRRGGEGHVLIINSIAGHQVLNFIDVLPSFN-IYPATKFAITAITETYRQEFQL 184
Query: 165 RNQGIRVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDT 224
+ IRV+ I P + T +F +++ Y + RL E + + D
Sbjct: 185 HSNKIRVTGICPGAVNTNIFPEEIH------FYVKDMARL------------EPANIADA 226
Query: 225 VLYSLQQTAPHIR 237
V+Y+L +T PH++
Sbjct: 227 VMYAL-RTPPHVQ 238
>CE21095 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 68.2 bits (165), Expect = 1e-11
Identities = 56/204 (27%), Positives = 84/204 (40%), Gaps = 14/204 (6%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPN-----------TNYSFKMVE 51
SNK V+ITG+S+GIG A +G V T R + + V
Sbjct: 5 SNKTVIITGSSNGIGRTTAILFAQEGANVTITGRSSERLEETRQIILKSGVSEKQVNSVV 64
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWA---AAEESSIEQSKFIFDTNLFG 108
DVT + + +K GKIDVL+NNAG I A + I+ NL
Sbjct: 65 ADVTTEDGQDQIINSTLKQFGKIDVLVNNAGAAIPDAFGTTGTDQGIDIYHKTLKLNLQA 124
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
V+ MT+ V PH+ Y+ +K AL+ YT + ++ G
Sbjct: 125 VIEMTKKVKPHLVASKGEIVNVSSIVAGPQAQPDFLYYAIAKAALDQYTRSTAIDLAKFG 184
Query: 169 IRVSVIDPHLIKTPMFSKDLEPDR 192
IRV+ + P +++T + PD+
Sbjct: 185 IRVNSVSPGMVETGFTNAMGMPDQ 208
>CE12990 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 67.8 bits (164), Expect = 2e-11
Identities = 52/191 (27%), Positives = 81/191 (42%), Gaps = 12/191 (6%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ-----------PNTNYSFKMVE 51
+ K V+ITG+SSGIG A +G +V T R + T S +V
Sbjct: 5 AGKSVIITGSSSGIGRATAVLFAKNGAQVTITGRNAEKLEATKKKLLKVVKTPDSVNVVV 64
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGI-SWAAAEESSIEQSKFIFDTNLFGVM 110
++T + +K GKID+LINNAG + + SI+ F N V+
Sbjct: 65 ANLTDAQGQDQIIQSAVKKFGKIDILINNAGANVVDGTVNTDQSIDLYHKTFQINFQAVV 124
Query: 111 RMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIR 170
M + ++ E V+ Y+A+K AL YT + ++ QG+R
Sbjct: 125 EMVKKTKKYLIESKGEIVNVSSIAAGPQAVSMSPYYAAAKAALNQYTRCVALDLIKQGVR 184
Query: 171 VSVIDPHLIKT 181
V+ + P +I T
Sbjct: 185 VNSVSPGIIAT 195
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 67.8 bits (164), Expect = 2e-11
Identities = 58/225 (25%), Positives = 93/225 (40%), Gaps = 21/225 (9%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKG-----------AQPNTNYSFKMVE 51
+ KV +ITG+S+GIG A +G +V T R A + + V
Sbjct: 5 AEKVAIITGSSNGIGRATAVLFAREGAKVTITGRHAERLEETRQQILAAGVSEQNVNSVV 64
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAE---ESSIEQSKFIFDTNLFG 108
DVT D ++ + GK+D+L+NNAG I + ++ SIE + NL
Sbjct: 65 ADVTTDAGQDEILSTTLGKFGKLDILVNNAGAAIPDSQSKTGTAQSIESYDATLNLNLRS 124
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
V+ +T+ +PH+ YS +K A++ YT ++ G
Sbjct: 125 VIALTKKAVPHLSSTKGEIVNISSIASGLHATPDFPYYSIAKAAIDQYTRNTAIDLIQHG 184
Query: 169 IRVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLE 213
IRV+ I P L+ T S + + ET K+ ++M E
Sbjct: 185 IRVNSISPGLVATGFGS-------AMGMPEETSKKFYSTMATMKE 222
>At5g50700 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 67.8 bits (164), Expect = 2e-11
Identities = 54/192 (28%), Positives = 89/192 (46%), Gaps = 19/192 (9%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDG-------------YEVFGTSRKGAQPNTNYSFKMVE 51
KVVLITGASSGIG +A + G EV +R+ PN V
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNV----VTVH 103
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
DV+K V + + + G++D L+NNAG+ I ++K + DTN +G +
Sbjct: 104 ADVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSVY 163
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRV 171
T+A LP++R Q + + Y+ASK AL ++ E + E+ + +
Sbjct: 164 TTRAALPYLR-QSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELGGD-VHI 221
Query: 172 SVIDPHLIKTPM 183
+++ P I++ +
Sbjct: 222 TIVTPGYIESEL 233
>At5g50600 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 67.8 bits (164), Expect = 2e-11
Identities = 54/192 (28%), Positives = 89/192 (46%), Gaps = 19/192 (9%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDG-------------YEVFGTSRKGAQPNTNYSFKMVE 51
KVVLITGASSGIG +A + G EV +R+ PN V
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNV----VTVH 103
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
DV+K V + + + G++D L+NNAG+ I ++K + DTN +G +
Sbjct: 104 ADVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSVY 163
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRV 171
T+A LP++R Q + + Y+ASK AL ++ E + E+ + +
Sbjct: 164 TTRAALPYLR-QSNGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELGGD-VHI 221
Query: 172 SVIDPHLIKTPM 183
+++ P I++ +
Sbjct: 222 TIVTPGYIESEL 233
>SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase
Length = 247
Score = 67.4 bits (163), Expect = 2e-11
Identities = 58/188 (30%), Positives = 85/188 (44%), Gaps = 12/188 (6%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNY------SFKMVELDVT 55
++ KV+L+TG+S GIGL AE LQ +V SR SF V+ DVT
Sbjct: 4 TAEKVILLTGSSKGIGLATAEALQKKA-KVIAVSRSLTPELETLLIQNPDSFVHVKGDVT 62
Query: 56 KDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
+ G + A +K GK+D +I NAGV A ++ I + + +FD N F V+ +
Sbjct: 63 EVGKASIETA--IKKFGKLDSVILNAGVLEPIAKIADADINEWRKLFDINFFSVVETVKY 120
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVID 175
+PH+R+ V A+ A Y SK A+ L E I +
Sbjct: 121 AIPHLRKTKGTIVIVSSGAAVRVFPAWAA-YCCSKAAINMLVMNLGSE--EPDIMSVAVR 177
Query: 176 PHLIKTPM 183
P ++ TPM
Sbjct: 178 PGVVDTPM 185
>At1g63380 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 287
Score = 67.4 bits (163), Expect = 2e-11
Identities = 57/193 (29%), Positives = 94/193 (48%), Gaps = 15/193 (7%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYS-----------FKMVEL 52
+KVVL+TGASSGIG +I L G ++ +R+ + N+ S +EL
Sbjct: 24 DKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAVALEL 83
Query: 53 DVTKDG-SVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
DV+ + ++ AV E + GKIDVLINNAG+ + ++ + S E+ +F TNL G
Sbjct: 84 DVSSEADTIRKAVKEAWETFGKIDVLINNAGIRGNVKSSLDLSEEEWDKVFRTNLTGSWL 143
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVP---VAFGAIYSASKHALEAYTEALDHEVRNQG 168
+++ V MR+ + + G Y+ SK ++ T + E+
Sbjct: 144 ISKYVCLLMRDAERGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELAVYK 203
Query: 169 IRVSVIDPHLIKT 181
IRV+ I P + ++
Sbjct: 204 IRVNSIAPGIFRS 216
>CE19894 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 67.0 bits (162), Expect = 3e-11
Identities = 54/190 (28%), Positives = 88/190 (45%), Gaps = 13/190 (6%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVE-LDVTKDGSVATA 63
KV ++T A+ GIGL IAE+L +G V SR Q N + + + ++ +TK +A
Sbjct: 11 KVAIVTAATKGIGLAIAERLLDEGASVVIGSRN--QKNVDEAIEYLKNKGLTKVAGIAGH 68
Query: 64 VAEV----------MKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
+A ++ GKI++L+NN G+ ++ E S + +F+ N+ +MT
Sbjct: 69 IASTDDQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQMT 128
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
+ V PH+ ++ A Y +K L T AL + IRV+
Sbjct: 129 KLVHPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIRVNG 188
Query: 174 IDPHLIKTPM 183
I P +IKT M
Sbjct: 189 IAPGVIKTKM 198
>At3g46170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 288
Score = 67.0 bits (162), Expect = 3e-11
Identities = 57/195 (29%), Positives = 96/195 (49%), Gaps = 20/195 (10%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK-----------GAQPNTNYSFKMVEL 52
+KVVL+TGASSGIG +I L G ++ +R+ + +T ++L
Sbjct: 28 DKVVLVTGASSGIGREICLDLGKAGCKIIAVARRVDRLNSLCSEINSSSSTGIQAAALKL 87
Query: 53 DVTKDGSVATAVAEVMKNA----GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFG 108
DVT D A + +V++ A GKID LINNAG+ + ++ + S E+ +F TNL G
Sbjct: 88 DVTSD---AATIQKVVQGAWGIFGKIDALINNAGIRGNVKSSLDLSKEEWDNVFKTNLTG 144
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXV-PVAFGAI-YSASKHALEAYTEALDHEVRN 166
+++ V MR+ + + GA+ Y+ SK ++ ++ + E+
Sbjct: 145 PWLVSKYVCVLMRDAKLGGSVINISSIAGIRGILPGALAYACSKIGVDTMSKMMAVELGV 204
Query: 167 QGIRVSVIDPHLIKT 181
IRV+ I P + K+
Sbjct: 205 HKIRVNSIAPGIFKS 219
>SPAC922.06 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 66.6 bits (161), Expect = 3e-11
Identities = 60/187 (32%), Positives = 91/187 (48%), Gaps = 12/187 (6%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAV 64
+VVLITGA+ GIG + + G V G + + + + DV+K + TA+
Sbjct: 6 RVVLITGAAGGIGKVLCKMFTELGDRVAGIDIVDPSKVQDAALAL-QADVSKADQIETAI 64
Query: 65 AEVMKNAGKIDVLINNAGVGISWAAAEESSIEQ-SKFIFDTNLFGVMR---MTQA-VLPH 119
+V++ G IDVLINNAG+ A+++ EQ S +D ++ V+R +TQ V+PH
Sbjct: 65 EKVIQTLGPIDVLINNAGL------ADDTPFEQLSHESWDHDVSLVLRGNYLTQRYVIPH 118
Query: 120 MREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHLI 179
M +Q YSA+K LE T+AL GIRV+V P I
Sbjct: 119 MAKQGKGGSIVNIGSVNGHIYLGSPAYSAAKAGLENLTKALAVRYGPLGIRVNVCAPGTI 178
Query: 180 KTPMFSK 186
+P + +
Sbjct: 179 WSPAWDE 185
>YIR035c [Q] KOG1204 Predicted dehydrogenase
Length = 254
Score = 66.2 bits (160), Expect = 4e-11
Identities = 63/234 (26%), Positives = 100/234 (41%), Gaps = 12/234 (5%)
Query: 5 KVVLITGASSGIGLDIAEKL-QLD-GYEVFGTSRKGA-----QPNTNYSFKMVELDVTKD 57
KV+L+TG S GIG I + L LD V+G +R A + F V D+T+D
Sbjct: 3 KVILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEAPLKKLKEKYGDRFFYVVGDITED 62
Query: 58 GSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVL 117
+ V +K GKID L+ NAGV E + K ++D N F ++ + L
Sbjct: 63 SVLKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSLVGIAL 122
Query: 118 PHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPH 177
P +++ ++GA Y +SK AL + L +E R ++ + P
Sbjct: 123 PELKKTNGNVVFVSSDACNMYFSSWGA-YGSSKAALNHFAMTLANEERQ--VKAIAVAPG 179
Query: 178 LIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQ--LESAEETSVVTDTVLYSL 229
++ T M E P S+ +E K E L+S+ +V L+ +
Sbjct: 180 IVDTDMQVNIRENVGPSSMSAEQLKMFRGLKENNQLLDSSVPATVYAKLALHGI 233
>At1g10310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 242
Score = 66.2 bits (160), Expect = 4e-11
Identities = 50/188 (26%), Positives = 88/188 (46%), Gaps = 8/188 (4%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKG-------AQPNTNYSFKMVELDVTKD 57
+ VLITG S G+G +A +L G+ V G +R ++ +++ + ++ DV +
Sbjct: 18 RTVLITGVSKGLGRALALELAKRGHTVIGCARSQEKLTALQSELSSSTNHLLLTADVKSN 77
Query: 58 GSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVL 117
SV +++ G D+++NNAG + E S E + DTN+ GV + + +
Sbjct: 78 SSVEEMAHTIVEKKGVPDIIVNNAGTINKNSKIWEVSAEDFDNVMDTNVKGVANVLRHFI 137
Query: 118 PHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPH 177
P M + A A Y ASK A+E + A+ EV +G+ V ++P
Sbjct: 138 PLMLPRKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKEV-VEGMAVVALNPG 196
Query: 178 LIKTPMFS 185
+I T + +
Sbjct: 197 VINTELLT 204
>At1g62610 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 307
Score = 65.9 bits (159), Expect = 6e-11
Identities = 57/193 (29%), Positives = 93/193 (47%), Gaps = 15/193 (7%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYS-----------FKMVEL 52
+KVVL+TGASSGIG +I L G ++ +R+ + N+ S +EL
Sbjct: 46 DKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAAALEL 105
Query: 53 DVTKDG-SVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
DV+ D ++ AV E + G IDVLINNAG+ + ++ + S E+ +F TNL G
Sbjct: 106 DVSSDADTIRKAVKEAWEIFGTIDVLINNAGIRGNVKSSLDLSKEEWDKVFRTNLTGSWL 165
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVP---VAFGAIYSASKHALEAYTEALDHEVRNQG 168
+++ V MR+ + + G Y+ SK ++ T + E+
Sbjct: 166 ISKYVCLLMRDAKRGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIELAVYK 225
Query: 169 IRVSVIDPHLIKT 181
IRV+ I P + ++
Sbjct: 226 IRVNSIAPGIFRS 238
>7290988 [Q] KOG1205 Predicted dehydrogenase
Length = 249
Score = 65.9 bits (159), Expect = 6e-11
Identities = 72/250 (28%), Positives = 104/250 (40%), Gaps = 39/250 (15%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK---------GAQPNTNYSFKMVELDV 54
N+V +I+GASSGIG A L G +V G +R+ F + DV
Sbjct: 6 NRVAVISGASSGIGAACARLLVAAGLQVVGLARRTDRLEQLRQSLPAEQRMRFHQHKCDV 65
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
+++ V TA + K G IDVLINNAG+ + + + + + I TNL G + T+
Sbjct: 66 SQELQVDTAFEWIEKELGGIDVLINNAGIVLGGQLIDMPTKDINN-ILQTNLMGSIYCTK 124
Query: 115 AVLPHMREQXXXXXXXXXXXXXXV------PVAFGA-IYSASKHALEAYTEALDHEVRNQ 167
MR + V P Y+ SK AL A E E+ NQ
Sbjct: 125 LAASSMRRRQVAGHLIFVNSTAGVAGYKPDPADESLNAYTPSKFALTAVQEICRQELINQ 184
Query: 168 G--IRVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDTV 225
G I+ + I+P + T ++ PD ET+ +L E + V V
Sbjct: 185 GSKIKTTSINPGWVAT-----EIVPD-------ETKAKLG-------EVILQADDVAQAV 225
Query: 226 LYSLQQTAPH 235
LY+L T PH
Sbjct: 226 LYAL-STPPH 234
>Hs5031737 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 65.5 bits (158), Expect = 8e-11
Identities = 56/194 (28%), Positives = 90/194 (45%), Gaps = 14/194 (7%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVE----------L 52
+N+V ++TG++SGIG IA +L DG V +SRK Q N + + ++
Sbjct: 35 ANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRK--QQNVDRAMAKLQGEGLSVAGIVC 92
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
V K VA+ +++ G +D L+ +AGV + +S + I N+ +
Sbjct: 93 HVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALL 152
Query: 113 TQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVS 172
+LP+M + VA G +Y+ SK AL T L E+ + IRV+
Sbjct: 153 LSQLLPYMENRRGAVILVSSIAAYNPVVALG-VYNVSKTALLGLTRTLALELAPKDIRVN 211
Query: 173 VIDPHLIKTPMFSK 186
+ P +IKT FSK
Sbjct: 212 CVVPGIIKTD-FSK 224
>Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 266
Score = 65.5 bits (158), Expect = 8e-11
Identities = 59/217 (27%), Positives = 95/217 (43%), Gaps = 25/217 (11%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEV--------FGTSRKGAQPNTNYSFK--MVEL 52
+ KV L+TGA+ GIG AE L L G +V G K A K ++
Sbjct: 4 NGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKTLFIQC 63
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
DV + +V+ + G++D+L+NNAGV E + E++ NL V+
Sbjct: 64 DVADQQQLRDTFRKVVDHFGRLDILVNNAGVN------NEKNWEKT---LQINLVSVISG 114
Query: 113 TQAVLPHMREQ---XXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTE--ALDHEVRNQ 167
T L +M +Q +PVA +Y ASKH + +T AL + N
Sbjct: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNS 174
Query: 168 GIRVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRL 204
G+R++ I P + T + + +E + + Y E + +
Sbjct: 175 GVRLNAICPGFVNTAIL-ESIEKEENMGQYIEYKDHI 210
>CE27260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 206
Score = 65.5 bits (158), Expect = 8e-11
Identities = 55/188 (29%), Positives = 88/188 (46%), Gaps = 15/188 (7%)
Query: 6 VVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVA 65
V ++TGASSGIG A L + Y++ T R A N + ++V K+ + TAV
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALN-ELAGQIVSAGSDKNDVLVTAVE 61
Query: 66 EVMKNA------------GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
+ A G+ID LIN+AG+ + +S IE + + N+ ++R+T
Sbjct: 62 LASEEAPKTIVDATVQKFGRIDTLINSAGI-LRAGPVLDSGIEVYDELMNVNVRSLIRLT 120
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
+A LPH+ P A Y SK A++ +T+ L E+ G+RV+
Sbjct: 121 RAALPHI-ITTKGTVVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNA 179
Query: 174 IDPHLIKT 181
+ P +I T
Sbjct: 180 VCPGVIVT 187
>CE14538 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 65.1 bits (157), Expect = 1e-10
Identities = 53/211 (25%), Positives = 85/211 (40%), Gaps = 16/211 (7%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYS-----------FKMVE 51
+++V ++TG+S+GIG A L +G +V T R + + V
Sbjct: 6 TDEVAIVTGSSNGIGRATAILLASEGAKVTITGRNAERLEESRQALLKVGVPSGHINSVV 65
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAG---VGISWAAAEESSIEQSKFIFDTNLFG 108
DVT + +K GKI++LINNAG V + +E F N
Sbjct: 66 ADVTTGAGQDVLIDSTLKKFGKINILINNAGALIVDPEGKTNTSTGVETCLKTFQLNFQS 125
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
V+ MTQ + PH+ YSA+K AL+ Y+ ++ G
Sbjct: 126 VVEMTQKIRPHLANTHGEIVNVSSVGAGPAAENRFPYYSAAKAALDQYSRNTAIDLIPDG 185
Query: 169 IRVSVIDPHLIKT--PMFSKDLEPDRPLSIY 197
IRV+++ P + T + + PD +Y
Sbjct: 186 IRVNIVQPGFVATGFTTAASGMSPDASAKMY 216
>7296705 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 65.1 bits (157), Expect = 1e-10
Identities = 49/190 (25%), Positives = 89/190 (46%), Gaps = 13/190 (6%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYS---------FKMVELDV 54
+KV+++TGASSGIG + L G + R + N V D+
Sbjct: 6 DKVIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVAADI 65
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
+ V V+ + G+IDVL+NNAG+ + + E +S+EQ + +TN+ + ++T
Sbjct: 66 NSESDVQGIVSATLAKHGRIDVLVNNAGI-LELGSIENTSLEQFDRVMNTNVRSLYQLTH 124
Query: 115 AVLPHM-REQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
V P + + + P Y+ SK A++ +T + E+ +G+RV+
Sbjct: 125 LVTPELIKTKGNIVNVSSVNGIRSFPGVLA--YNVSKAAVDQFTRCVALELAPKGVRVNS 182
Query: 174 IDPHLIKTPM 183
++P +I T +
Sbjct: 183 VNPGVIITEL 192
>7295621 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 65.1 bits (157), Expect = 1e-10
Identities = 58/204 (28%), Positives = 91/204 (44%), Gaps = 22/204 (10%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ--------PNTNYS-FKMVELDV 54
N V ++TGASSGIG I KL G V +R+ + P S ++++ DV
Sbjct: 6 NCVAVVTGASSGIGAAITRKLISAGVMVVALARRMDRLEQLREELPQDRRSRLRIMQCDV 65
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
+ SV V + G +D+LINNAG +S S++ + + TN+ GV+ TQ
Sbjct: 66 SDVSSVNAVFDAVQGDLGNVDILINNAG-KLSGGQLLTMSVDTVQQMLQTNVMGVVYCTQ 124
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGAI---------YSASKHALEAYTEALDHEVR 165
MR++ + F + Y A+KHA+ A TE E+R
Sbjct: 125 RAFESMRQRQSKGHVVLINSIVGHYI-FNPLPGSQQELNMYPATKHAITALTELFRQEMR 183
Query: 166 N--QGIRVSVIDPHLIKTPMFSKD 187
+ ++V+ I P L+ T + D
Sbjct: 184 DFKTKVKVTSISPGLVDTELVPLD 207
>7295487 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 317
Score = 65.1 bits (157), Expect = 1e-10
Identities = 57/218 (26%), Positives = 95/218 (43%), Gaps = 12/218 (5%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNT--------NYSFKMVELDV 54
+ KV ++T ++ GIG IA++L DG V +SRK ++ N + ++ V
Sbjct: 70 AGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLKCHV 129
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
++ E + GK+++L++NA + E + IFD N+ + +
Sbjct: 130 SEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKSSYLLAK 189
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVI 174
LP +R+Q YS SK AL T+A ++ +GIRV+ +
Sbjct: 190 EALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKDLAPEGIRVNCL 249
Query: 175 DPHLIKTPMFSKDL---EPDRPLSIYSETRKRLATSME 209
P +I+T FSK L E ++ RL TS E
Sbjct: 250 APGVIRT-KFSKALYENESANEAALSKIPMGRLGTSEE 286
>Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 318
Score = 64.7 bits (156), Expect = 1e-10
Identities = 70/284 (24%), Positives = 120/284 (41%), Gaps = 26/284 (9%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFGT-----SRKGAQPNTNYSFKMVELDVTK 56
+SN V ITG SG G +A +L + V + + Q + F LD+T
Sbjct: 26 ASNAFVFITGCDSGFGRLLALQLDQKSFRVLASCLTPSGAEDLQGVASSGFNTTLLDITD 85
Query: 57 DGSVATAVAEV---MKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
S A V +K AG L+NNAGV + + + + + N G + +T
Sbjct: 86 PQSFQQAAKWVEMHVKEAGLFG-LVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVT 144
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
A+LP +++ A G Y SK LEA++++L +V + GIR S+
Sbjct: 145 LALLPLLQQARGRVINITSVLGRLA--ANGGGYCVSKFGLEAFSDSLRRDVAHFGIRESI 202
Query: 174 IDPHLIKTPM-----FSKDLE------PDRPLSIYSETRKRLATSMEKQLESA---EETS 219
++P +TP+ K L+ P + Y M++++ + + +
Sbjct: 203 VEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNLICDPDLT 262
Query: 220 VVTDTVLYSLQQTAPHIRYTPG-RAKRFAYFRYYAPSAIFDRVI 262
V+ + ++L P RY+PG AK Y P+++ D V+
Sbjct: 263 KVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVL 306
>CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 64.7 bits (156), Expect = 1e-10
Identities = 48/195 (24%), Positives = 88/195 (44%), Gaps = 20/195 (10%)
Query: 5 KVVLITGASSGIGLDIAEK------------LQLDGYEVFGTSRKGAQPNTNYSFKMVEL 52
K VLITGA +G+G +A+K + L + +G Q + E+
Sbjct: 41 KKVLITGAGNGLGKLLAQKFAARGATLILWDINLQSVDELKNEIRGNQGEAH----SYEV 96
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
++ G +A +V+ + GK+D+L+NNAG+ + + S E ++ FD N+
Sbjct: 97 NLCDPGKIAQVGQQVINDIGKVDILVNNAGIATAKMILDSSENEINR-SFDVNVKAHFYT 155
Query: 113 TQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEV---RNQGI 169
Q LP M + + + A YS++KHA + ++L E+ G+
Sbjct: 156 VQQFLPAMLKDNNGHIVTIASAAGKMGSSGLADYSSTKHAAVGFHDSLVAEIMESEKNGV 215
Query: 170 RVSVIDPHLIKTPMF 184
+ +++ P+ + T MF
Sbjct: 216 KTTLVCPYYVHTSMF 230
>7296047 [Q] KOG1205 Predicted dehydrogenase
Length = 321
Score = 64.3 bits (155), Expect = 2e-10
Identities = 56/195 (28%), Positives = 90/195 (45%), Gaps = 23/195 (11%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPN--------------TNYSFKMV 50
+VV ITGASSGIG +A L G ++ ++R+ Q ++
Sbjct: 47 QVVWITGASSGIGRALALSLARHGVKLVLSARRLEQLEQVQEECLAAARGLLATKDVLVI 106
Query: 51 ELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVG--ISWAAAEESSIEQSKFIFDTNLFG 108
++D+ T + V+ + ++DVL+NNAG SW E IE + +F+ ++F
Sbjct: 107 QMDMLDLDEHKTHLNTVLNHFHRLDVLVNNAGRSQRASWTEVE---IEVDRELFELDVFA 163
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXX--VPVAFGAIYSASKHALEAYTEALDHEVRN 166
V+ +++ V+ + EQ PV F Y A+KHAL AY +L E+R
Sbjct: 164 VVHLSRLVVRYFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVEMRK 223
Query: 167 QGIRVSVIDPHLIKT 181
+ VS+ P I T
Sbjct: 224 --LDVSLFAPGPIAT 236
>CE27259 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 501
Score = 63.9 bits (154), Expect = 2e-10
Identities = 57/211 (27%), Positives = 95/211 (45%), Gaps = 19/211 (9%)
Query: 6 VVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVA 65
V ++TGASSGIG A L + Y++ T R A N + ++V K+ + TAV
Sbjct: 3 VAIVTGASSGIGRAAALLLARNNYKLSLTGRNVAALN-ELAGQIVSAGSDKNDVLVTAVE 61
Query: 66 EVMKNA------------GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
+ A G+ID LIN+AG+ + +S IE + + N+ ++R+T
Sbjct: 62 LASEEAPKTIVDATVQKFGRIDTLINSAGI-LRAGPVLDSGIEVYDELMNVNVRSLIRLT 120
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAI--YSASKHALEAYTEALDHEVRNQGIRV 171
+A LPH+ P F + Y SK A++ +T+ L E+ G+RV
Sbjct: 121 RAALPHI---ITTKGTVVNVSSINGPCPFPNVTYYCMSKSAVDQFTKCLALEMAPNGVRV 177
Query: 172 SVIDPHLIKTPMFSKDLEPDRPLSIYSETRK 202
+ + P + T + + + S + E K
Sbjct: 178 NAVCPGVTVTNLHRTSGQDETTYSAFLERSK 208
>CE05801 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 374
Score = 63.9 bits (154), Expect = 2e-10
Identities = 71/312 (22%), Positives = 113/312 (35%), Gaps = 68/312 (21%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFG------TSRKGAQPNTNYSFKMVELDVTKD 57
++ +LITG +G G ++A+K +G+ VF ++ + N + V LDV+KD
Sbjct: 28 DRAILITGCDTGFGRELAKKCAKNGFLVFAGCLTTEAAKTLESESANPRLRTVPLDVSKD 87
Query: 58 GSVATAVAEVMKNAG--KIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
SV V V K+ G K+ ++NNAG+ + + + K D N GV+R+TQA
Sbjct: 88 ESVEKTVEFVKKSLGNHKLWGVVNNAGIFSCYGPDDWCRMNDYKLALDVNCLGVIRVTQA 147
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEAL--------------- 160
++ A G Y SK AY + +
Sbjct: 148 FKKLVKAAKGRIVTVTSVNGRLSTPAAGP-YVVSKFGAAAYMDCIRFVIGVLDILIKFSV 206
Query: 161 ------------------------------DHEVRNQGIRVSVIDPHLIKTPMFSKDLE- 189
E+ N G++VS+++P + +TP+ +
Sbjct: 207 FSFVFKNDIQLLPISNFSSLMFGFRIVQEYKQELYNFGVKVSILEPGIFRTPLLDEQAML 266
Query: 190 ----------PDRPLSIYSETRKRLATSM-EKQLESAEETSV--VTDTVLYSLQQTAPHI 236
D + Y ET K M K S T + V D ++L P
Sbjct: 267 KRVDHVWTQIDDETRTEYGETFKNYFAKMWNKTYISMSTTKIHYVVDNYYHALTAKYPRH 326
Query: 237 RYTPGRAKRFAY 248
RY G F Y
Sbjct: 327 RYYCGWDAIFVY 338
>7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 361
Score = 63.9 bits (154), Expect = 2e-10
Identities = 49/191 (25%), Positives = 84/191 (43%), Gaps = 13/191 (6%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYE--VFGTSRKGAQPNTNYSFKMVEL-------D 53
S KV L+TG SG+G +I +L G + V + KG K+ D
Sbjct: 91 SGKVALVTGGGSGLGREICLELARRGCKLAVVDVNSKGCYETVELLSKIPRCVAKAYKND 150
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
V+ + A+V K G +D+L+NNA + + + ++ I NL + T
Sbjct: 151 VSSPRELQLMAAKVEKELGPVDILVNNASL-MPMTSTPSLKSDEIDTILQLNLGSYIMTT 209
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG---IR 170
+ LP M + VP+ IY+A+K+ +E + E+L E+R +R
Sbjct: 210 KEFLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAELRLSDCDYVR 269
Query: 171 VSVIDPHLIKT 181
+V + +L++T
Sbjct: 270 TTVANAYLMRT 280
>SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 63.5 bits (153), Expect = 3e-10
Identities = 48/200 (24%), Positives = 83/200 (41%), Gaps = 12/200 (6%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELD--------- 53
+ K L+TG SGIG A +G ++ + + + + ++E +
Sbjct: 41 AEKKTLLTGGDSGIGKAAAVMFAREGSDLVISCLPEERDDAEVTRDLIEREGRNCWIWEG 100
Query: 54 -VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
+ K + V +K G IDVL+NN + E+ EQ F TN+F +
Sbjct: 101 KLDKSDNCRDLVDFALKKLGWIDVLVNNIAYQQVAQSIEDIDDEQWDLTFKTNIFSFFWV 160
Query: 113 TQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVS 172
T+A + HM+ P Y+++K A+ A+T L ++ GIRV+
Sbjct: 161 TKAAISHMKSGSSIVNCSSINAYVGRPDLLD--YTSTKGAITAFTRGLSNQYAQHGIRVN 218
Query: 173 VIDPHLIKTPMFSKDLEPDR 192
+ P I TP+ S ++
Sbjct: 219 AVAPGPIYTPLVSSTFPKEK 238
>7292690 [Q] KOG1205 Predicted dehydrogenase
Length = 251
Score = 63.5 bits (153), Expect = 3e-10
Identities = 60/212 (28%), Positives = 90/212 (42%), Gaps = 21/212 (9%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR--------KGAQPNTNYS-FKMVELDV 54
N+V ++TGASSGIG + L G V G +R K + P S F + DV
Sbjct: 6 NRVAVVTGASSGIGAACCKDLVSKGLVVVGLARREDRLQELKASLPADQASRFHGRKCDV 65
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAG-VGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
+++ V A A + G DVL+NNAG V + E + + I DTN+ GV T
Sbjct: 66 SQEQEVIDAFAWIDATLGGADVLVNNAGIVRLGVGITHEGNGADLRAILDTNVLGVSWCT 125
Query: 114 QAVLPHMREQ------XXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ 167
+ ++ + P +YS SK+A+ A TE L E N
Sbjct: 126 REAFKSLKRRNVNDGHILIVNSVAGHRVINNPGITMGMYSPSKYAVTALTEVLRQEFHNN 185
Query: 168 --GIRVSVIDPHLIKTPMFSKDL---EPDRPL 194
+++ I P + T + K+ PD P+
Sbjct: 186 KTQTKITSISPGAVDTEIIDKEALVGIPDFPM 217
>7292613 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 63.2 bits (152), Expect = 4e-10
Identities = 66/253 (26%), Positives = 106/253 (41%), Gaps = 40/253 (15%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK-------GAQPNTNYSFKMVEL--DV 54
N+V ++TGASSGIG IA+ L L G V G +R+ + K+ L DV
Sbjct: 6 NRVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRVKELQRELPAEKRGKLFALYCDV 65
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
+ SV A +++ G IDVL+NNAG + + + + + TN+ G++ TQ
Sbjct: 66 GNESSVNEAFDWIIQKLGAIDVLVNNAGT-LQPGYLVDMNPAVMQQVLQTNIMGIVLCTQ 124
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGA--------IYSASKHALEAYTEALDHEVRN 166
+ MRE+ +Y SKHA+ A E E
Sbjct: 125 RAVRSMRERKFDGHVVLINSILGHKTMTATEGVAPDVNVYPPSKHAVTALAEGYRQEFFG 184
Query: 167 QGIRVSV--IDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDT 224
G R+ + + P ++ T ++ PD SI + R+ S + +
Sbjct: 185 LGTRIKITSVSPGVVDT-----EIVPD---SIREAIKDRMLHSED-----------IAQG 225
Query: 225 VLYSLQQTAPHIR 237
VLY++ T PH++
Sbjct: 226 VLYAI-ATPPHVQ 237
>Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 179
Score = 62.8 bits (151), Expect = 5e-10
Identities = 50/181 (27%), Positives = 79/181 (43%), Gaps = 12/181 (6%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR-----KGAQPNTNYSFKMVELDVTKDG 58
+KV + G S GIG +A+ + GY + +R K A + DV K+
Sbjct: 2 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEH 61
Query: 59 SVATAVAEVMKNAGKIDVLINNAGV---GISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
V E+ K+ G+++ L+N AG+ G+ E + Q TNL G M +A
Sbjct: 62 DVQNTFEEMEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQ----LHTNLLGSMLTCKA 117
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVID 175
+ M +Q + ++YSASK L ++ AL EV + IRV+V+
Sbjct: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVA 177
Query: 176 P 176
P
Sbjct: 178 P 178
>SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 62.4 bits (150), Expect = 6e-10
Identities = 59/229 (25%), Positives = 100/229 (42%), Gaps = 19/229 (8%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQL-DGYEVFGTSRKGAQPN-------TNYSFKMVELD 53
++NKV I G + GIGL + ++L +G VF ++RK ++ + K VELD
Sbjct: 3 TTNKVYFIAGGNRGIGLSLVKELSSREGTTVFASARKPEAATELQEWSKSHPNVKTVELD 62
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
VT S A V K IDVL N+G+ S+ E+ E + TN+ G + +
Sbjct: 63 VTSQQSANEAAQSVAKAVDGIDVLWLNSGICQSYYTVMEAPEEVWNAHYQTNVLGPIHVF 122
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXV----PVAFGAIYSASKHALEAYTEALDHEVRNQGI 169
+A P + ++ + F A Y SK A+ + L E+ ++
Sbjct: 123 KAFYPLLTKKKTRQVIFTSSECGSMGDFRATGFSA-YGQSKAAINFTMKELSVELADEHF 181
Query: 170 RVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEET 218
I P ++KT M + ++ ++ET + T ++K EE+
Sbjct: 182 TFISIHPGVVKTDMNADAIKK------FTETSPEMLTYLKKVTIIPEES 224
>At3g05260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 289
Score = 62.4 bits (150), Expect = 6e-10
Identities = 59/223 (26%), Positives = 96/223 (42%), Gaps = 23/223 (10%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTN-------YSFK--------M 49
KV L+TG SGIG + L+G V T KG + + K M
Sbjct: 40 KVALVTGGDSGIGKAVCHCYALEGASVAFTYVKGREDKDAEETLRLLHEVKTREAKEPIM 99
Query: 50 VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVG--ISWAAAEESSIEQSKFIFDTNLF 107
+ D+ + + V EV+ + G+IDVL+N A +S +E+ +E+ +F TN+F
Sbjct: 100 IATDLGFEENCKRVVEEVVNSFGRIDVLVNCAAEQHEVSIEDIDEARLER---VFRTNIF 156
Query: 108 GVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ 167
+ + L HM+E Y+A+K A+ ++T L ++ +
Sbjct: 157 SQFFLVKYALKHMKEGSSIINTTSVVAYAGNSSLLE--YTATKGAIVSFTRGLALQLAPK 214
Query: 168 GIRVSVIDPHLIKTPMFSKDLEPDRPLSIYSET-RKRLATSME 209
GIRV+ + P + TP+ + SET KR A +E
Sbjct: 215 GIRVNGVAPGPVWTPLIPASFSEEAIKQFGSETPMKRAAQPVE 257
>At1g07440 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 266
Score = 62.4 bits (150), Expect = 6e-10
Identities = 63/242 (26%), Positives = 95/242 (39%), Gaps = 22/242 (9%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAV 64
K VL+TG + GIG I E+ G + +R + N S K + GSV A
Sbjct: 15 KTVLVTGGTKGIGHAIVEEFAGFGAVIHTCARNEYELNECLS-KWQKKGFQVTGSVCDAS 73
Query: 65 AEVMKN----------AGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
+ GK+D+LINN G I + + E F TNL ++Q
Sbjct: 74 LRPEREKLMQTVSSMFGGKLDILINNLGA-IRSKPTLDYTAEDFSFHISTNLESAYHLSQ 132
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVI 174
P ++ V + G+IYSA+K AL L E + GIR + +
Sbjct: 133 LAHPLLKASGCGNIIFMSSIAGVVSASVGSIYSATKGALNQLARNLACEWASDGIRANAV 192
Query: 175 DPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDTVLYSLQQTAP 234
P +I TP+ ++Y + K++ S K L E V+ V + A
Sbjct: 193 APAVIATPLAE---------AVYDDEFKKVVIS-RKPLGRFGEPEEVSSLVAFLCMPAAS 242
Query: 235 HI 236
+I
Sbjct: 243 YI 244
>At2g29150 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 62.0 bits (149), Expect = 8e-10
Identities = 61/243 (25%), Positives = 100/243 (41%), Gaps = 30/243 (12%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVAEV 67
L+TG S G+G + E+L + G V +R T ++ E K V T+V +V
Sbjct: 22 LVTGGSKGLGEAVVEELAMLGARVHTCARD----ETQLQERLREWQA-KGFEVTTSVCDV 76
Query: 68 MKNA--------------GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
GK+++L+NNAG GI + E ++ E F+ TNL ++
Sbjct: 77 SSREQREKLMETVSSVFQGKLNILVNNAGTGIIKPSTEYTA-EDYSFLMATNLESAFHLS 135
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
Q P ++ V +IY ASK A+ +L E + IRV+
Sbjct: 136 QIAHPLLKASGSGSIVFMSSVAGLVHTG-ASIYGASKGAMNQLGRSLACEWASDNIRVNS 194
Query: 174 IDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDTVLYSLQQTA 233
+ P +I TP+ S I+S+ + R A + + E + V+ V + A
Sbjct: 195 VCPWVITTPLTS---------FIFSDEKLRKAVEDKTPMGRVGEANEVSSLVAFLCFPAA 245
Query: 234 PHI 236
+I
Sbjct: 246 SYI 248
>At3g26770 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 61.6 bits (148), Expect = 1e-09
Identities = 62/236 (26%), Positives = 99/236 (41%), Gaps = 20/236 (8%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVF------GTSRKGAQPNTNYSFKMVELDVTKDG 58
KV LITG +SG+G A + G V T K A+ + V DVT +
Sbjct: 18 KVALITGGASGLGKATASEFLRHGARVVIADLDAETGTKTAK-ELGSEAEFVRCDVTVEA 76
Query: 59 SVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKF--IFDTNLFGVMRMTQAV 116
+A AV ++ GK+DV+ NNAG+ A S ++ ++F + N+FGV+ +
Sbjct: 77 DIAGAVEMTVERYGKLDVMYNNAGIVGPMTPASISQLDMTEFERVMRINVFGVV----SG 132
Query: 117 LPHMREQXXXXXXXXXXXXXXVPVAFGAI----YSASKHALEAYTEALDHEVRNQGIRVS 172
+ H + V G + Y+ SK ++ E+ G+R++
Sbjct: 133 IKHAAKFMIPARSGCILCTSSVAGVTGGLAPHSYTISKFTTPGIVKSAASELCEHGVRIN 192
Query: 173 VIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAE-ETSVVTDTVLY 227
I P + TP+ L+ P SE + R +L+ AE E + V LY
Sbjct: 193 CISPGTVATPLTLSYLQKVFPK--VSEEKLRETVKGMGELKGAECEEADVAKAALY 246
>7300731 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 61.6 bits (148), Expect = 1e-09
Identities = 54/198 (27%), Positives = 83/198 (41%), Gaps = 17/198 (8%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR--------KGAQPNTNYS-FKMVELDV 54
N+V ++TGAS+GIG L G V G +R K + P + F DV
Sbjct: 6 NRVAVVTGASAGIGAACCRDLVAKGMVVVGLARREKVLQDIKSSLPADQAARFHTRPCDV 65
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
+ + V A + + G DVL+NNAG+ + + + I D N+ GV T+
Sbjct: 66 SNEQQVIDTFAWIDRTLGGADVLVNNAGIIRQMNITDPENSADVRAILDVNVLGVTWCTR 125
Query: 115 ---AVLPHMREQXXXXXXXXXXXXXXVPVAFG---AIYSASKHALEAYTEALDHEVRNQG 168
L + VP G +Y+ SKHA+ A TE L E +G
Sbjct: 126 QWFLSLQRRKVNDGHVVVINSVVGHSVPAVEGFSLNMYAPSKHAITALTEILRQEFIKKG 185
Query: 169 --IRVSVIDPHLIKTPMF 184
+++ I P ++ T +F
Sbjct: 186 TQTKITSISPGVVATEIF 203
>CE02490_1 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 302
Score = 61.6 bits (148), Expect = 1e-09
Identities = 45/132 (34%), Positives = 66/132 (49%), Gaps = 16/132 (12%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ----PNTNYS-FKMVE-------- 51
+ VLITGAS GIG +IA KL DG + ++ P T YS + +E
Sbjct: 10 RTVLITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYSAAEEIEKAGGKALP 69
Query: 52 --LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGV 109
+DV + SV +V E +K G ID+LINNA IS E + +++ + N G
Sbjct: 70 CIVDVRDEASVKASVEEAVKKFGGIDILINNAS-AISLTDTENTEMKRYDLMHSINTRGT 128
Query: 110 MRMTQAVLPHMR 121
MT+ LP+++
Sbjct: 129 FLMTKTCLPYLK 140
>YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 900
Score = 61.2 bits (147), Expect = 1e-09
Identities = 59/220 (26%), Positives = 91/220 (40%), Gaps = 29/220 (13%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVEL---DVTKDGSV 60
++VV+ITGA G+G A G +V G + ++ K +L ++ K G +
Sbjct: 9 DRVVVITGAGGGLGKVYALAYASRGAKVVVNDLGGTLGGSGHNSKAADLVVDEIKKAGGI 68
Query: 61 ATA------------VAEVMKNAGKIDVLINNAGV--GISWAAAEESSIEQSKFIFDTNL 106
A A + +K G++DVLINNAG+ +S+A E + D +L
Sbjct: 69 AVANYDSVNENGEKIIETAIKEFGRVDVLINNAGILRDVSFAKMTEREFAS---VVDVHL 125
Query: 107 FGVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRN 166
G ++++A P+MR Q A YSA+K L E L E
Sbjct: 126 TGGYKLSRAAWPYMRSQKFGRIINTASPAGLFGNFGQANYSAAKMGLVGLAETLAKEGAK 185
Query: 167 QGIRVSVIDP-------HLIKTPMFSKDLEPDR--PLSIY 197
I V+ I P + P K L P++ PL +Y
Sbjct: 186 YNINVNSIAPLARSRMTENVLPPHILKQLGPEKIVPLVLY 225
>YIR036c [Q] KOG1204 Predicted dehydrogenase
Length = 263
Score = 61.2 bits (147), Expect = 1e-09
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 16/198 (8%)
Query: 5 KVVLITGASSGIGLDIAEKL--QLDGYEVFGTSRKGAQPNTNY------SFKMVELDVTK 56
KV+LITGAS GIGL + + + + D V+G +R A + F LD+T
Sbjct: 3 KVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQREYGADKFVYRVLDITD 62
Query: 57 DGSVATAVAEVMKNAGKIDVLINNAGV-----GISWAAAEESSIEQSKFIFDTNLFGVMR 111
+ V E+ + GK+D ++ NAG+ IS + +E I+Q + +FD N F ++
Sbjct: 63 RSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEH-DIKQWERLFDVNFFSIVS 121
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXV-PVAFGAIYSASKHALEAYTEALDHEVRNQGIR 170
+ LP ++ V P + Y SK AL + + E + +R
Sbjct: 122 LVALCLPLLKSSPFVGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPSDKVR 181
Query: 171 VSVIDPHLIKTPMFSKDL 188
I P ++ T M KD+
Sbjct: 182 AVCIAPGVVDTQM-QKDI 198
>At2g47120 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 61.2 bits (147), Expect = 1e-09
Identities = 55/205 (26%), Positives = 83/205 (39%), Gaps = 10/205 (4%)
Query: 5 KVVLITGASSGIGLDIAEKLQ--------LDGYEVFGTSRKGAQPNTNYSFKMVELDVTK 56
K+V+ITG +SGIG D A +D E G + SF DVT
Sbjct: 9 KIVIITGGASGIGADAARLFTDHGAKVVIVDVQEELGQNVAVLIGKDKASF--YRCDVTN 66
Query: 57 DGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
+ V AV ++ GK+DVL +NAGV + + +E+ I N+ G +
Sbjct: 67 ETEVEDAVKFTVEKHGKLDVLFSNAGVLEPLESFLDFDLERFDRIMAVNVRGAAAFIKHA 126
Query: 117 LPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDP 176
M E+ Y+ASKH L + ++ GIRV+ + P
Sbjct: 127 ARAMVEKGTRGSIVCTTSVSAEIGGGHHGYTASKHGLVGLIRSACGDLGKYGIRVNGVAP 186
Query: 177 HLIKTPMFSKDLEPDRPLSIYSETR 201
+ + TPM S D + L Y + +
Sbjct: 187 YAVATPMTSHDEVTGKQLEDYFDAK 211
>At2g29290 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 61.2 bits (147), Expect = 1e-09
Identities = 50/187 (26%), Positives = 80/187 (42%), Gaps = 10/187 (5%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNY-SFKMVELDVTK---DGSVATA 63
L+TG + GIG + E+L + G V +R Q ++ VT D S+
Sbjct: 13 LVTGGTKGIGEAVVEELSILGARVHTCARDETQLQERLREWQEKGFQVTTSICDVSLREQ 72
Query: 64 VAEVMKNA-----GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLP 118
++M+ GK+++L+NN G + E + E+ F+ TNL ++Q P
Sbjct: 73 REKLMETVSSLFQGKLNILVNNVGT-LMLKPTTEYTAEEFSFLMATNLDSAFHISQLAHP 131
Query: 119 HMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHL 178
++ V V G+IY A+K A+ L E + IR + I P L
Sbjct: 132 LLKASGSGSIVLMSSIAGVVHVGVGSIYGATKGAMNQLARNLACEWASDNIRTNAICPWL 191
Query: 179 IKTPMFS 185
I TP+ S
Sbjct: 192 ITTPLIS 198
>SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 60.8 bits (146), Expect = 2e-09
Identities = 47/191 (24%), Positives = 89/191 (45%), Gaps = 11/191 (5%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQ-LDGYEVFGTSRKGAQPN-------TNYSFKMVELD 53
++NK+ I G + GIGL + ++L +G VF ++RK ++ + +++LD
Sbjct: 3 TTNKIYFIAGGNRGIGLSLVKELSNREGTVVFASARKPEAATELQEWSKSHSNVHIIKLD 62
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
++ S A EV K GK+DVL N+G+ S+ + + + TN+ G + +
Sbjct: 63 ISSLESANEAAQEVAKAVGKVDVLWVNSGIFHSFNTVLNTPDDVWNSHYKTNVLGPIHVY 122
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAF---GAIYSASKHALEAYTEALDHEVRNQGIR 170
QA P +++ + F + Y SK AL + + E++++G
Sbjct: 123 QAFYPLVKKGESKIIVFTSSLVGSMGAFFPFNQSGYGQSKAALNFTMKEISFELQDEGFI 182
Query: 171 VSVIDPHLIKT 181
V I P +++T
Sbjct: 183 VISIHPGMVRT 193
>Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 261
Score = 60.8 bits (146), Expect = 2e-09
Identities = 53/198 (26%), Positives = 81/198 (40%), Gaps = 20/198 (10%)
Query: 6 VVLITGASSGIGLDIAEKLQLDGYEVF-------GTSRKGAQPNTNYSFKMVELDVTKDG 58
V +ITG +SG+GL AE+L G G + + N F DVT +
Sbjct: 12 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF--APADVTSEK 69
Query: 59 SVATAVAEVMKNAGKIDVLINNAGVGI-----SWAAAEESSIEQSKFIFDTNLFGVMRMT 113
V TA+A G++DV +N AG+ + + + ++E + + D NL G +
Sbjct: 70 DVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVI 129
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAF------GAIYSASKHALEAYTEALDHEVRNQ 167
+ V M + VA A YSASK + T + ++
Sbjct: 130 RLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPI 189
Query: 168 GIRVSVIDPHLIKTPMFS 185
GIRV I P L TP+ +
Sbjct: 190 GIRVMTIAPGLFGTPLLT 207
>Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 310
Score = 60.8 bits (146), Expect = 2e-09
Identities = 51/193 (26%), Positives = 91/193 (46%), Gaps = 14/193 (7%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK---------GAQPNTNYSFKMVEL 52
S + +ITGA GIG + +L G V SR + T S K+++
Sbjct: 46 SMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQA 105
Query: 53 DVTKDGSVATAVAEVMKNAG-KIDVLINNAGVGISWAAAEE-SSIEQSKFIFDTNLFGVM 110
D TKD + + E K AG +I +L+NN G+ + + ++ ++ + + N+ V+
Sbjct: 106 DFTKD-DIYEHIKE--KLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVV 162
Query: 111 RMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIR 170
+MTQ +L HM + P ++YSASK + A+++AL E + + +
Sbjct: 163 KMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVI 222
Query: 171 VSVIDPHLIKTPM 183
+ V+ P+ + T M
Sbjct: 223 IQVLTPYAVSTAM 235
>CE21092 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 60.8 bits (146), Expect = 2e-09
Identities = 52/194 (26%), Positives = 82/194 (41%), Gaps = 16/194 (8%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ-----------PNTNYSFKMVE 51
S+KV +ITG+SSGIG A L +G +V T R + ++ + +V
Sbjct: 5 SDKVAIITGSSSGIGRSTAVLLAQEGAKVTVTGRSSEKIQETVNEIHKNGGSSDNINIVL 64
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFD----TNLF 107
D+ + + + GKID+LINNAG + + + S E + IFD NL
Sbjct: 65 GDLNESECQDELIKSTLSRFGKIDILINNAGAAFADPSGKIGS-EAAIGIFDDMMKLNLR 123
Query: 108 GVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ 167
V+ + + PH+ P + Y K L+ T +L E+
Sbjct: 124 SVVELVKKCRPHLIASKGEIVNVSSIAAGPQPYIYYTYYGICKAGLDQLTRSLALELIPF 183
Query: 168 GIRVSVIDPHLIKT 181
+RV+ + P LI T
Sbjct: 184 DVRVNSVSPGLIST 197
>At5g61830 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 60.8 bits (146), Expect = 2e-09
Identities = 40/135 (29%), Positives = 68/135 (49%), Gaps = 22/135 (16%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMV----------- 50
S V ++TG++ GIG +IA +L + G V T+R N N + V
Sbjct: 34 SCENVAVVTGSNRGIGFEIARQLAVHGLTVVLTAR-----NVNAGLEAVKSLRHQEEGLK 88
Query: 51 ----ELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNL 106
+LDVT S+ + + G +D+L+NNAGV ++ ++++E ++ + TN
Sbjct: 89 VYFHQLDVTDSSSIREFGCWLKQTFGGLDILVNNAGV--NYNLGSDNTVEFAETVISTNY 146
Query: 107 FGVMRMTQAVLPHMR 121
G MT+A++P MR
Sbjct: 147 QGTKNMTKAMIPLMR 161
>At2g29350 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 60.8 bits (146), Expect = 2e-09
Identities = 50/190 (26%), Positives = 78/190 (40%), Gaps = 20/190 (10%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVAEV 67
L+TG S GIG + E+L + G +V +R T ++ E K V T+V +V
Sbjct: 21 LVTGGSKGIGEAVVEELAMLGAKVHTCARD----ETQLQERLREWQA-KGFQVTTSVCDV 75
Query: 68 MKN--------------AGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
GK+++L+NN G I + E + E F+ TNL ++
Sbjct: 76 SSRDQRVKLMETVSSLYQGKLNILVNNVGTSI-FKPTTEYTAEDFSFVMATNLESAFHLS 134
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
Q P ++ V V G+IY A+K A+ L E + IR +
Sbjct: 135 QLAHPLLKASGSGSIVLISSAAGVVHVNVGSIYGATKGAMNQLARNLACEWASDNIRTNS 194
Query: 174 IDPHLIKTPM 183
+ P I TP+
Sbjct: 195 VCPWYITTPL 204
>At1g52340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 285
Score = 60.8 bits (146), Expect = 2e-09
Identities = 53/193 (27%), Positives = 81/193 (41%), Gaps = 17/193 (8%)
Query: 5 KVVLITGASSGIGLDIAE------------KLQLD-GYEVFGTSRKGAQPNTNYSFKMVE 51
KV LITG ++GIG I LQ D G EV + +G T + +
Sbjct: 21 KVALITGGATGIGESIVRLFHKHGAKVCIVDLQDDLGGEVCKSLLRGESKETAF---FIH 77
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGV-GISWAAAEESSIEQSKFIFDTNLFGVM 110
DV + ++ AV +KN G +D+LINNAG+ G S+ + + FD N+ G
Sbjct: 78 GDVRVEDDISNAVDFAVKNFGTLDILINNAGLCGAPCPDIRNYSLSEFEMTFDVNVKGAF 137
Query: 111 RMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIR 170
+ M + V Y SKHA+ T ++ E+ GIR
Sbjct: 138 LSMKHAARVMIPEKKGSIVSLCSVGGVVGGVGPHSYVGSKHAVLGLTRSVAAELGQHGIR 197
Query: 171 VSVIDPHLIKTPM 183
V+ + P+ + T +
Sbjct: 198 VNCVSPYAVATKL 210
>7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 308
Score = 60.8 bits (146), Expect = 2e-09
Identities = 48/188 (25%), Positives = 83/188 (43%), Gaps = 13/188 (6%)
Query: 9 ITGASSGIGLDIAEKLQLDGYEVF----------GTSRKGAQPNTNYSFKMVELDVTKDG 58
+TGAS GIG + A++L V +++ A K+V D TK
Sbjct: 54 VTGASDGIGKEYAKELARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIADFTKGS 113
Query: 59 SVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLP 118
V + + N I +L+NN G+ + + + E+++ I DTN+ V ++++
Sbjct: 114 QVYEHIEKETANI-PISILVNNVGIATPKSLLKYNQ-EETQNIIDTNVVAVSQLSRIFFQ 171
Query: 119 HMREQXXXXXXXXXXXXXXV-PVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPH 177
M+ + P+ GA Y+ASK + T AL HE + GI V ++ P+
Sbjct: 172 RMKASKLKGAIVNVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQMLSPN 231
Query: 178 LIKTPMFS 185
+ T + S
Sbjct: 232 FVVTKINS 239
>SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 236
Score = 60.5 bits (145), Expect = 2e-09
Identities = 54/195 (27%), Positives = 92/195 (46%), Gaps = 18/195 (9%)
Query: 7 VLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVAE 66
VLITG SSG+G IA+ G++ R + + L V K +A+
Sbjct: 4 VLITGGSSGLGKRIAQIWSQKGHQCHIVGRN----EFHLKETLQSLSVAKGQQHTLTIAD 59
Query: 67 V---MKN------AGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ-AV 116
V MKN + +ID +++ AGV + + +S ++ I TNL +++++ A+
Sbjct: 60 VQSDMKNLKSIFESVEIDTVVHAAGV-LQSSLCVRTSEKEIDSIICTNLVSAIKLSKMAI 118
Query: 117 LPHMREQXXXXXXXXXXXXXXVP---VAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
L R + + + ++Y+ASK LE++T+ L EV ++GIRV+
Sbjct: 119 LEWFRNKNSERDRLILNISSRLSTYALPGTSVYAASKAGLESFTKVLAAEVASKGIRVNA 178
Query: 174 IDPHLIKTPMFSKDL 188
I P + TPM S +
Sbjct: 179 ISPGYVDTPMLSSQI 193
>CE05726 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 60.5 bits (145), Expect = 2e-09
Identities = 50/193 (25%), Positives = 79/193 (40%), Gaps = 16/193 (8%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR-------------KGAQPNTNYSFKM 49
S K V+ITG+S+GIG A +G +V T R K P +
Sbjct: 5 SGKSVIITGSSNGIGRSAAVIFAKEGAQVTITGRNEDRLEETKQQILKAGVPAEKIN--A 62
Query: 50 VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAE-ESSIEQSKFIFDTNLFG 108
V DVT+ + + GKID+L+NNAG ++ A + +E + F N
Sbjct: 63 VVADVTEASGQDDIINTTLAKFGKIDILVNNAGANLADGTANTDQPVELYQKTFKLNFQA 122
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
V+ MTQ H+ + + Y+ +K AL+ YT ++ G
Sbjct: 123 VIEMTQKTKEHLIKTKGEIVNVSSIVAGPQAHSGYPYYACAKAALDQYTRCTAIDLIQHG 182
Query: 169 IRVSVIDPHLIKT 181
+RV+ + P + T
Sbjct: 183 VRVNSVSPGAVAT 195
>Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 312
Score = 60.1 bits (144), Expect = 3e-09
Identities = 45/186 (24%), Positives = 83/186 (44%), Gaps = 10/186 (5%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKG-----AQPNTNYSFKMVELDVTKDGSVAT 62
++TG++ GIG AE+L G +V SR FK+ + D +
Sbjct: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113
Query: 63 AVAEVMKNAG--KIDVLINNAGVGISWAA--AEESSIEQS-KFIFDTNLFGVMRMTQAVL 117
++ +I +L+NN G+ + + ++ K + + N+ V +MTQ VL
Sbjct: 114 IYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVL 173
Query: 118 PHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPH 177
P M E+ +PV IYSA+K ++ +++ L E R++G+ V + P+
Sbjct: 174 PGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPY 233
Query: 178 LIKTPM 183
+ T +
Sbjct: 234 FVATKL 239
>At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 305
Score = 60.1 bits (144), Expect = 3e-09
Identities = 55/196 (28%), Positives = 89/196 (45%), Gaps = 21/196 (10%)
Query: 8 LITGASSGIG----LDIAEK---------LQLDGYEVFGTSRKG-AQPNTNYSFK---MV 50
L+TG +SGIG L +AEK + G E R+ A+ + SF V
Sbjct: 10 LVTGGASGIGRALCLALAEKGVFVTVADFSEEKGQETTSLVREANAKFHQGLSFPSAIFV 69
Query: 51 ELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVG--ISWAAAEESSIEQSKFIFDTNLFG 108
+ DVT G + A + + G +D+ INNAG+ + + + + K + +L
Sbjct: 70 KCDVTNRGDLLAAFDKHLATFGTLDICINNAGISTPLRFDKDDTDGSKSWKHTINVDLIA 129
Query: 109 VMRMTQAVLPHMR-EQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ 167
V+ TQ + M+ +Q P+ IY+ASK + +T +L + R Q
Sbjct: 130 VVEGTQLAIKAMKAKQKPGVIINMGSAAGLYPMPVDPIYAASKAGVVLFTRSLAY-YRRQ 188
Query: 168 GIRVSVIDPHLIKTPM 183
GIR++V+ P IKT +
Sbjct: 189 GIRINVLCPEFIKTDL 204
>At2g47130 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 59.7 bits (143), Expect = 4e-09
Identities = 58/207 (28%), Positives = 90/207 (43%), Gaps = 19/207 (9%)
Query: 5 KVVLITGASSGIGLDI--------AEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTK 56
K+ +ITG +SGIG + A+ + +D E G + + SF DVT
Sbjct: 9 KIAIITGGASGIGAEAVRLFTDHGAKVVIVDFQEELGQNVAVSVGKDKASF--YRCDVTN 66
Query: 57 DGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
+ V AV ++ GK+DVL +NAGV + + ++EQ FD + +R A
Sbjct: 67 EKEVENAVKFTVEKYGKLDVLFSNAGVMEQPGSFLDLNLEQ----FDRTMAVNVRGAAAF 122
Query: 117 LPHM-REQXXXXXXXXXXXXXXVPVAFGA----IYSASKHALEAYTEALDHEVRNQGIRV 171
+ H R V G Y+ASKHAL ++ + GIRV
Sbjct: 123 IKHAARAMVEKGTRGSIVCTTSVASEIGGPGPHAYTASKHALLGLVKSACGGLGKYGIRV 182
Query: 172 SVIDPHLIKTPMFSKDLEPDRPLSIYS 198
+ + P+ + T + S+D E R + YS
Sbjct: 183 NGVAPYAVATAINSRDEETVRMVEEYS 209
>YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 326
Score = 59.3 bits (142), Expect = 5e-09
Identities = 52/189 (27%), Positives = 87/189 (45%), Gaps = 9/189 (4%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVEL--DVTKDGSVA 61
N +VLITG S G+G I +L L Y P++ + ++ +L D++ D VA
Sbjct: 70 NGIVLITGGSKGLGRAIVSQL-LQDYSNLTILNVDICPSSVRNTRVKDLICDLSDDEEVA 128
Query: 62 TAVAEVMKNAGK--IDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLPH 119
A+ ++K K I +++NNAGV ++ + IF N F ++ Q + P
Sbjct: 129 -ALLNLLKRKYKNEIRLIVNNAGVRANFTGFNGMERDNLDKIFKINTFAPLQFIQELAPS 187
Query: 120 MREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG---IRVSVIDP 176
+ A A Y+ASK AL A+ ++ E++N+G IR ++ P
Sbjct: 188 RHSTRQCYIVNIASILGILTPAKVAAYAASKAALIAFHQSYSFELQNEGVRNIRTLLVTP 247
Query: 177 HLIKTPMFS 185
+ T MF+
Sbjct: 248 GQLNTEMFA 256
>At5g51030 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 314
Score = 59.3 bits (142), Expect = 5e-09
Identities = 39/128 (30%), Positives = 63/128 (48%), Gaps = 10/128 (7%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK---GAQP-----NTNYSFKMVELD 53
+S V ++TGA+ GIG ++ +L G V TSR G + ++ LD
Sbjct: 35 TSETVAVVTGANRGIGFEMVRQLAGHGLTVILTSRDENVGVEAAKILQEGGFNVDFHRLD 94
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
+ S+ + + G IDVLINNAGV ++ ++S+E S + TN +G +
Sbjct: 95 ILDSSSIQEFCEWIKEKYGFIDVLINNAGV--NYNVGSDNSVEFSHMVISTNYYGTKNII 152
Query: 114 QAVLPHMR 121
A++P MR
Sbjct: 153 NAMIPLMR 160
>7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 255
Score = 59.3 bits (142), Expect = 5e-09
Identities = 54/202 (26%), Positives = 87/202 (42%), Gaps = 18/202 (8%)
Query: 1 MSSNKVVLITGASSGIGLDIAEKLQLDGYEVFGT---SRKGAQPNTNYSFKMV--ELDVT 55
M N V L+TG +SG+G AE+L G V S KG + K+V +DVT
Sbjct: 1 MIKNAVSLVTGGASGLGRATAERLAKQGASVILADLPSSKGNEVAKELGDKVVFVPVDVT 60
Query: 56 KDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESS-----IEQSKFIFDTNL---F 107
+ V+ A+ G++D+ +N AG + + +E + + + N F
Sbjct: 61 SEKDVSAALQTAKDKFGRLDLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVININTVGTF 120
Query: 108 GVMRMTQAVL----PHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHE 163
V+R++ ++ P+ Q + A YSASK A+ T + +
Sbjct: 121 NVIRLSAGLMGANEPNQDGQRGVIVNTASVAAFDGQIGQAA-YSASKAAVVGMTLPIARD 179
Query: 164 VRNQGIRVSVIDPHLIKTPMFS 185
+ QGIR+ I P L TPM +
Sbjct: 180 LSTQGIRICTIAPGLFNTPMLA 201
>7296706_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 233
Score = 59.3 bits (142), Expect = 5e-09
Identities = 35/138 (25%), Positives = 70/138 (50%), Gaps = 4/138 (2%)
Query: 50 VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGV 109
++ D+TK+ V V + G+IDVL+NNAG+ + + E +S+EQ + +TN+ +
Sbjct: 37 LQADMTKEAEVQQIVGATLAKHGRIDVLVNNAGI-LETGSIEATSLEQFDRLMNTNVRSL 95
Query: 110 MRMTQAVLPHM-REQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
++T P + + + P Y+ SK A++ +T + E+ +G
Sbjct: 96 YQLTMLATPELVKTKGNIVNVSSVCGLRAFPGVLA--YNVSKAAVDQFTACIALELAPKG 153
Query: 169 IRVSVIDPHLIKTPMFSK 186
+RV+ ++P +I T + +
Sbjct: 154 VRVNAVNPGVIVTDIHKR 171
>CE12594 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 58.9 bits (141), Expect = 7e-09
Identities = 48/191 (25%), Positives = 79/191 (41%), Gaps = 12/191 (6%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ-PNTNYSFKMVELDVTKDGSVA 61
S K ++ITG+SSGIG A +G +V T R + T + K +V
Sbjct: 5 SGKSIIITGSSSGIGRSAAVIFAKEGAQVTITGRSADRLEETRLQILKAGVPAEKINAVV 64
Query: 62 TAVAEV----------MKNAGKIDVLINNAGVGISWAAAE-ESSIEQSKFIFDTNLFGVM 110
V E + GKID+L+NNAG ++ + + ++E + F N V+
Sbjct: 65 ADVCEASGQDEVIRTTLAKFGKIDILVNNAGALLTDGTSNTDQAVELYQKTFKLNFQAVV 124
Query: 111 RMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIR 170
MTQ ++ + Y+ +K AL+ YT ++ G+R
Sbjct: 125 EMTQKTKEYLIKTKGEIVNVSSIVAGPQAQPASPYYACAKAALDQYTRCTAIDLIQHGVR 184
Query: 171 VSVIDPHLIKT 181
V+ + P +I T
Sbjct: 185 VNSVSPGVIAT 195
>CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 258
Score = 58.9 bits (141), Expect = 7e-09
Identities = 52/194 (26%), Positives = 77/194 (38%), Gaps = 14/194 (7%)
Query: 6 VVLITGASSGIGLDIAEKLQLDGYEVFGTS---RKGAQPNTNYSFKMVELDVTKDGSVAT 62
V L+TG +SG+G AE L G +V KGA VT + V
Sbjct: 11 VALVTGGASGLGKGAAEVLAKAGAQVAILDLPQSKGADVAKEIGGIFTPASVTSEEEVRA 70
Query: 63 AVAEVMKNAGKIDVLINNAGVGISWAA-----AEESSIEQSKFIFDTNLFGVMRMTQAVL 117
A A+V G++D L+N AG+ ++ + E+ + D N+ G + + +
Sbjct: 71 AFAKVQAEYGRLDALVNCAGIAYAFKLYSVQKKKHVDFEKIRQTIDVNVLGTFNVIRHGV 130
Query: 118 PHMREQXXXXXXXXXXXXXXVPVAF------GAIYSASKHALEAYTEALDHEVRNQGIRV 171
M E VA + YSASK A+ T L + GIR
Sbjct: 131 ALMGEHEKDANGQRGVVINTASVAAFDGQTGQSAYSASKGAIVGMTLPLARDFAGDGIRF 190
Query: 172 SVIDPHLIKTPMFS 185
+ I P L+ TP+ S
Sbjct: 191 NTIAPGLMDTPLLS 204
>At1g01800 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 309
Score = 58.9 bits (141), Expect = 7e-09
Identities = 37/130 (28%), Positives = 68/130 (51%), Gaps = 15/130 (11%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR------------KGAQPNTNYSFKMVE 51
++V ++TG++ GIG +I +L +G V T+R K ++ +
Sbjct: 34 SRVAVVTGSNKGIGFEICRQLANNGITVVLTARDENKGLAAVQKLKTENGFSDQAISFHP 93
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFD---TNLFG 108
LDV+ ++A+ A V GK+D+L+NNAGVG + + + ++ + + TN +G
Sbjct: 94 LDVSNPDTIASLAAFVKTRFGKLDILVNNAGVGGANVNVDVLKAQIAEIVEECVKTNYYG 153
Query: 109 VMRMTQAVLP 118
V RM +A++P
Sbjct: 154 VKRMCEAMIP 163
>Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 387
Score = 58.5 bits (140), Expect = 9e-09
Identities = 65/281 (23%), Positives = 118/281 (41%), Gaps = 29/281 (10%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVF-------GTSRKGAQPNTNYSFKMVELDVTKD 57
K VL+TG G+G + + L G+ VF G + + + ++++D+TK
Sbjct: 83 KAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKP 142
Query: 58 GSVATA---VAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
+ A VA ++++ G + +INNAGV E + K N FG + +T+
Sbjct: 143 VQIKDAYSKVAAMLQDRG-LWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTK 201
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVI 174
LP +R + P+ A Y +SK A+ ++ + E+ GI+V+ I
Sbjct: 202 TFLPLLR-KSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASI 260
Query: 175 DPHLIKTPM---------FSKDLEPDRPLSIYSE------TRKRLATSMEKQLESAEETS 219
P T + KD+ P + + +R + L S + +
Sbjct: 261 QPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDFSP 320
Query: 220 VVTDTVLYSLQQTAPHIRYTPGR-AKRFAYFRYYAPSAIFD 259
V+ D + +++ +P YTPG+ A + +Y P I+D
Sbjct: 321 VLRD-IQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD 360
>Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 332
Score = 58.5 bits (140), Expect = 9e-09
Identities = 47/194 (24%), Positives = 85/194 (43%), Gaps = 14/194 (7%)
Query: 7 VLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQP------------NTNYSFKMVELDV 54
V++TG SSGIG IA + G + +R + N + +DV
Sbjct: 35 VVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDV 94
Query: 55 TKD-GSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
++D V + + + G +D+L+N AG+ +S E+ + + + N G + +
Sbjct: 95 SQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVS-GKFEDLEVSTFERLMSINYLGSVYPS 153
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
+AV+ M+E+ + + YSASK A+ EAL EV+ + ++V
Sbjct: 154 RAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITV 213
Query: 174 IDPHLIKTPMFSKD 187
P TP F+++
Sbjct: 214 AYPPDTDTPGFAEE 227
>CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 58.2 bits (139), Expect = 1e-08
Identities = 59/246 (23%), Positives = 96/246 (38%), Gaps = 28/246 (11%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVAEV 67
++TGA+ GIG A L G+ +F SR ++ K L+ D V A+ +
Sbjct: 57 VVTGATDGIGRSYALDLARRGFNIFLISRTKSKL---VKTKKQILNKYSDIEVRYAICDF 113
Query: 68 MK-------------NAGKIDVLINNAGVGISWAAA---EESSIEQSKFIFDTNLFGVMR 111
+ N I +LINN G+ E I+ + + N ++
Sbjct: 114 TRVSYEDYKRLLHSLNEVDIGILINNVGMCFDNPEVLHRVEGGIDTLTNVINVN---ILP 170
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRV 171
+T +LP M + + +A ++YSA+K +E +T L E N+GI
Sbjct: 171 LTAGILPQMMARKSGIIVNIGSAAGSIHMAKWSVYSATKKYIEWFTSILQKEYENEGIIC 230
Query: 172 SVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQL-ESAEETSVVTDTVLYSLQ 230
I P L+ T M L SI+ A S + S+ T +T + + L
Sbjct: 231 QTITPLLVSTNMIKNPLS-----SIFCPNSDSFAKSSLNTIGNSSSTTGYITHQIQFELI 285
Query: 231 QTAPHI 236
+ P I
Sbjct: 286 KFVPEI 291
>At3g59710 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 302
Score = 58.2 bits (139), Expect = 1e-08
Identities = 40/129 (31%), Positives = 66/129 (51%), Gaps = 11/129 (8%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR------KGAQPNTNYSFKMVE---L 52
S ++TGA+ GIG + ++L G V T+R + A+ F V L
Sbjct: 26 SEETTAVVTGANKGIGFAVVKRLLELGLTVVLTARNAENGSQAAESLRRIGFGNVHFCCL 85
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
D++ S+A + +N G +D+L+NNA V S+ A E+ I++ + I TN +G +
Sbjct: 86 DISDPSSIAAFASWFGRNLGILDILVNNAAV--SFNAVGENLIKEPETIIKTNFYGAKLL 143
Query: 113 TQAVLPHMR 121
T+A+LP R
Sbjct: 144 TEALLPLFR 152
>At3g42960 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 272
Score = 58.2 bits (139), Expect = 1e-08
Identities = 45/181 (24%), Positives = 75/181 (40%), Gaps = 4/181 (2%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTS---RKGAQPNTNYSFKMVELDVTKDGSVA 61
KV +ITG + GIG A +G V +G + V DV+K+ V
Sbjct: 11 KVAIITGGARGIGAATARLFTENGAYVIVADILENEGILVAESIGGCYVHCDVSKEADVE 70
Query: 62 TAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR-MTQAVLPHM 120
AV M+ G++DV+ NNAG+ ++ + ++ + N+ GV+ + A +
Sbjct: 71 AAVELAMRRKGRLDVMFNNAGMSLNEGSIMGMDVDMVNKLVSVNVNGVLHGIKHAAKAMI 130
Query: 121 REQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHLIK 180
+ + G Y+ SK A+ E+ + GIRV+ I PH +
Sbjct: 131 KGGRGGSIICTSSSSGLMGGLGGHAYTLSKGAINGVVRTTACELGSHGIRVNSISPHGVP 190
Query: 181 T 181
T
Sbjct: 191 T 191
>At2g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 322
Score = 58.2 bits (139), Expect = 1e-08
Identities = 57/203 (28%), Positives = 86/203 (42%), Gaps = 11/203 (5%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSR-----KGAQPNTNYSFKMVELDV--TKDGSV 60
L+TG + GIG I E+L G EV +R + + N S V V D S
Sbjct: 74 LVTGGTRGIGRAIVEELAGLGAEVHTCARNEYELENCLSDWNRSGFRVAGSVCDVSDRSQ 133
Query: 61 ATAVAEVMKNA--GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLP 118
A+ E + + GK+ +L+NN G I E ++ E S + TN V + Q P
Sbjct: 134 REALMETVSSVFEGKLHILVNNVGTNIRKPMVEFTAGEFST-LMSTNFESVFHLCQLAYP 192
Query: 119 HMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHL 178
+RE V + ++ S++K A+ T +L E IR++ + P
Sbjct: 193 LLRESKAGSVVFISSVSGFVSLKNMSVQSSTKGAINQLTRSLACEWAKDNIRINAVAPWY 252
Query: 179 IKTPMFSKDLEPDRPL-SIYSET 200
IKT M + L L +YS T
Sbjct: 253 IKTSMVEQVLSNKEYLEEVYSVT 275
>7300831 [Q] KOG1205 Predicted dehydrogenase
Length = 248
Score = 58.2 bits (139), Expect = 1e-08
Identities = 53/196 (27%), Positives = 85/196 (43%), Gaps = 15/196 (7%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK-----GAQPNTNYSFKMV--ELDVTK 56
NKV ++TGAS GIG A +L G V G +R+ + K+ + D+
Sbjct: 9 NKVAVVTGASVGIGATTAIELANAGMVVVGLARRVELIEALRDQVTGVGKIFARQCDLND 68
Query: 57 DGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
+ +A+A + + I VLI NAG+ + ES + K +FDTN+ +
Sbjct: 69 EEQLASAFNWIREKFQAIHVLICNAGI-LKANFLSESPTKDIKELFDTNVVATASCLREA 127
Query: 117 LPHM-----REQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVR--NQGI 169
L HM R VPV ++Y A+KHA+ A + + E+ I
Sbjct: 128 LKHMAAVKVRGHIVVMNSVLGHRIPEVPVPLFSVYPATKHAITALCQTVRQEIHFLKLNI 187
Query: 170 RVSVIDPHLIKTPMFS 185
+++ I P ++ T S
Sbjct: 188 KLTSICPGMVDTDFLS 203
>CE20725 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/194 (25%), Positives = 77/194 (39%), Gaps = 16/194 (8%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ-PNTNYSFK----------MVE 51
S KV LITG+S+GIG A G +V T R + T + K +
Sbjct: 5 SGKVALITGSSNGIGRAAAILFAQQGAKVTITGRNAERLKETRHEIKKSGIPAENILAIV 64
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDT----NLF 107
DV D + + ++ G +D+L+NNAG G A ++Q +FD N+
Sbjct: 65 ADVITDEGQMRLINDTVRKFGHLDILVNNAG-GALMDAQGRVGMDQDISVFDNTMQINMR 123
Query: 108 GVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ 167
V+ + Q H+ + Y SK AL+ +T + +
Sbjct: 124 SVVTLVQKAKEHLIKSKGEIINVSAMAAGHHGDPIATFYGMSKAALDQFTRSSAISLIQH 183
Query: 168 GIRVSVIDPHLIKT 181
G+RV+ + P KT
Sbjct: 184 GVRVNSVSPGFTKT 197
>YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 308
Score = 57.4 bits (137), Expect = 2e-08
Identities = 55/208 (26%), Positives = 86/208 (40%), Gaps = 19/208 (9%)
Query: 1 MSSNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKG----AQPNTNYSFKMVELDVTK 56
+S N LITG SSG+G ++A++L +V + AQ N F + D+T
Sbjct: 35 LSKNATALITGGSSGLGFELAKELSRRINKVIVADIQSFPTFAQVEYNNIF-YYQCDITS 93
Query: 57 DGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
+ + ++ G I+++INNAGV E + ++ + + D NL G R+
Sbjct: 94 LDEIKNLKKAIERDHGNINIIINNAGVA-HIKKLEHMTNKEVEQLIDINLIGAYRIISTF 152
Query: 117 LPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHA-------LEAYTEALDHEVRNQGI 169
M + + A Y ASK A + + +L E GI
Sbjct: 153 AEDMIDNREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLSTECNKTGI 212
Query: 170 RVSVIDPHLIKTPMF------SKDLEPD 191
+ ++ P IKT MF SK L PD
Sbjct: 213 KTLLVCPGKIKTNMFIDVPTPSKLLAPD 240
>SPCC24B10.20 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 254
Score = 57.4 bits (137), Expect = 2e-08
Identities = 57/232 (24%), Positives = 100/232 (42%), Gaps = 15/232 (6%)
Query: 6 VVLITGASSGIGLDIAEKLQ-LDGYEVFGTSRKGAQPN-------TNYSFKMVELDVTKD 57
V +I G + GIGL + ++L +G VF ++R + T+ + +++LDVT
Sbjct: 8 VYVIVGGNRGIGLSLVKELSNKEGVTVFASARGPGSASELKDWSKTHSNVHIIKLDVTSL 67
Query: 58 GSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVL 117
S A +V K IDVL N+G+ S+ ++S E + TN+ G + + QA
Sbjct: 68 RSAKDAAMQVEKVVKCIDVLWVNSGISKSFQPVLKTSDELWMSHYQTNVLGPIHVYQAFY 127
Query: 118 PHMREQXXXXXXXXXXXXXXV----PVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
++E + P + A Y SK AL + + E+ G V
Sbjct: 128 HLLKEGKLKNIVFTSSMAACMGGVRPNTYSA-YGQSKAALNYTMKEISFELEKDGFVVVS 186
Query: 174 IDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDTV 225
I P ++ T MF ++ + S Y E + + ++ +SA + D +
Sbjct: 187 IHPGVVNTDMFVNAMQ--KLASKYPEMVESIKSNAISPEQSASSMLKIVDNL 236
>CE05427 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 293
Score = 57.0 bits (136), Expect = 3e-08
Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 16/135 (11%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ----PNTNYSFKM--------- 49
+ K V ITGAS GIG +IA KL DG + ++ P T Y+
Sbjct: 12 AGKTVFITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYTAAAEIEKAGGHA 71
Query: 50 --VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLF 107
+DV + +V AV +K G ID+LINNA IS E++ +++ + N
Sbjct: 72 LPCVVDVRDEAAVKAAVDAAVKKFGGIDILINNAS-AISLTNTEDTDMKRYDLMHSINTR 130
Query: 108 GVMRMTQAVLPHMRE 122
G +T+ LP++++
Sbjct: 131 GTYLLTKTCLPYLKK 145
>At4g10020 [Q] KOG1205 Predicted dehydrogenase
Length = 389
Score = 57.0 bits (136), Expect = 3e-08
Identities = 48/180 (26%), Positives = 80/180 (43%), Gaps = 13/180 (7%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR----------KGAQPNTNYSFKMVELD 53
+KVV+ITGASS IG IA + G + +R K Q N+ ++ D
Sbjct: 49 DKVVVITGASSAIGEQIAYEYAKRGANLVLVARREQRLRVVSNKAKQIGANHVI-IIAAD 107
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
V K+ + + + G++D L+N A +G ++ E S + D N +G + T
Sbjct: 108 VIKEDDCRRFITQAVNYYGRVDHLVNTASLGHTFYFEEVSDTTVFPHLLDINFWGNVYPT 167
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ-GIRVS 172
LP++ Q +P+ ++YSA+K AL + E L E+ GI ++
Sbjct: 168 YVALPYL-HQTNGRIVVNASVENWLPLPRMSLYSAAKAALVNFYETLRFELNGDVGITIA 226
>Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 341
Score = 56.6 bits (135), Expect = 4e-08
Identities = 47/171 (27%), Positives = 71/171 (41%), Gaps = 13/171 (7%)
Query: 33 GTSRKGAQPNTNYSFKMVELDVTKDGSVATAVAEVMKNAGKIDVLINNAGV--GISWAAA 90
G + P+ N DV K +V V K G++ VL+NNAGV G
Sbjct: 98 GNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLEC 157
Query: 91 EESSIEQSKFIFDTNLFGVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASK 150
+ IE++ + N T+A LP M E A Y ASK
Sbjct: 158 PDELIERTMMV---NCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASK 214
Query: 151 HALEAYTEALDHEVR---NQGIRVSVIDPHLIKTPMF-----SKDLEPDRP 193
+ + E+L HE++ GI+ +++ P+L+ T MF K++EP P
Sbjct: 215 FGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLP 265
>At5g50690 [Q] KOG1205 Predicted dehydrogenase
Length = 303
Score = 56.6 bits (135), Expect = 4e-08
Identities = 55/200 (27%), Positives = 90/200 (44%), Gaps = 21/200 (10%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDG-------------YEVFGTSRKGAQPNTNYSFKM 49
+ KVV+ITG+SSGIG +A + G V RK P+ +
Sbjct: 46 NGKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDV----AV 101
Query: 50 VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGV 109
V DV+ V E + G++D L+NNAG+ + + S I I +TN +G
Sbjct: 102 VRGDVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGP 161
Query: 110 MRMTQAVLPHMRE-QXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
+ T +PH+++ + VP +IY+ASK A+ + E L E+ +
Sbjct: 162 VYATHFAIPHLKKTKGKIIAVASPAGWSGVPRM--SIYAASKAAMINFYETLRIELHPE- 218
Query: 169 IRVSVIDPHLIKTPMFSKDL 188
+ V+++ P LI+ + DL
Sbjct: 219 VGVTIVFPGLIENGNTNPDL 238
>At5g50590 [Q] KOG1205 Predicted dehydrogenase
Length = 299
Score = 56.6 bits (135), Expect = 4e-08
Identities = 55/200 (27%), Positives = 90/200 (44%), Gaps = 21/200 (10%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDG-------------YEVFGTSRKGAQPNTNYSFKM 49
+ KVV+ITG+SSGIG +A + G V RK P+ +
Sbjct: 46 NGKVVIITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDV----AV 101
Query: 50 VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGV 109
V DV+ V E + G++D L+NNAG+ + + S I I +TN +G
Sbjct: 102 VRGDVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGP 161
Query: 110 MRMTQAVLPHMRE-QXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
+ T +PH+++ + VP +IY+ASK A+ + E L E+ +
Sbjct: 162 VYATHFAIPHLKKTKGKIIAVASPAGWSGVPRM--SIYAASKAAMINFYETLRIELHPE- 218
Query: 169 IRVSVIDPHLIKTPMFSKDL 188
+ V+++ P LI+ + DL
Sbjct: 219 VGVTIVFPGLIENGNTNPDL 238
>CE09969 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 56.2 bits (134), Expect = 5e-08
Identities = 49/213 (23%), Positives = 93/213 (43%), Gaps = 16/213 (7%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELD-VTKDGSVA 61
+++V L+T ++ GIG IA++L G V SRK + N + + + L+ + G+ A
Sbjct: 10 TDRVALVTASTKGIGFAIAKQLGAAGASVVVCSRK--KENVDEAVAALRLENIDAHGTTA 67
Query: 62 ---------TAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
+ + K+D+L++NA V + + + Q + D N+ +
Sbjct: 68 HVGNKSDRTKLIDFTLDRFTKLDILVSNAAVNPHYGDLMKVTDSQWDKLLDLNVKSAFEL 127
Query: 113 TQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVS 172
T+ +PH+ P+ YS K L +++L + + IRV+
Sbjct: 128 TKEAVPHLEASGRGNVVFVSSVAGYSPMNEIGAYSVMKTTLTGLSKSLALNLARRNIRVN 187
Query: 173 VIDPHLIKTP----MFSKDLEPDRPLSIYSETR 201
I P +I+T +FS + E + LS ++ R
Sbjct: 188 SIAPGIIQTDFSQVLFSDESEKQKWLSQIAQRR 220
>At2g29310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 56.2 bits (134), Expect = 5e-08
Identities = 52/196 (26%), Positives = 79/196 (39%), Gaps = 20/196 (10%)
Query: 8 LITGASSGIGLDIAEKLQLDG--------------YEVFGTSRKGAQPNTNYSFKMVELD 53
L+TGA+SGIG I E+L G + +KG Q + + D
Sbjct: 13 LVTGAASGIGYAIVEELASFGAIIHICDISETLLSQSLSEWEKKGFQVSGSICDVASRPD 72
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
K +++ + GK+++L+NN GV I E E + TNL +
Sbjct: 73 REKLMQTVSSLFD-----GKLNILVNNVGV-IRGKPTTEYVAEDFSYHISTNLEPAFHFS 126
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
Q ++ V V G+IYS +K AL T L E GIR +
Sbjct: 127 QLSHLLLKASGFGSIVFMSSATGVVSVQCGSIYSLTKGALNQLTRNLACEWAKDGIRANA 186
Query: 174 IDPHLIKTPMFSKDLE 189
+ P+++KTP+ LE
Sbjct: 187 VAPNVVKTPLSQSYLE 202
>7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 399
Score = 56.2 bits (134), Expect = 5e-08
Identities = 58/193 (30%), Positives = 84/193 (43%), Gaps = 17/193 (8%)
Query: 6 VVLITGASSGIGLDIAEKLQLDGYEV--FGTSRKGAQPNTNYS------FKMVELDVTKD 57
+ LITG +G+G +AE+L G +V + ++KG K +D++K
Sbjct: 88 IALITGGGNGLGRLLAERLGKMGTKVVIWDINKKGIAETVQIVEEAGGYCKGYVVDISKK 147
Query: 58 GSVATAVAEVMKNAGKIDVLINNAGV--GISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
V A + G I +LINNAGV G+ + IE+S F+ N+ T+A
Sbjct: 148 EEVYKAADVIRDEVGDITLLINNAGVVSGLHLLDTPDHLIERS---FNVNVMAHFWTTKA 204
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG---IRVS 172
LP M E V ++ Y ASK A + EAL E+ G IR +
Sbjct: 205 FLPKMIENDRGHIATIASLAGHVGISKLVDYCASKFAAVGFDEALRLELEVLGHTNIRTT 264
Query: 173 VIDPHLIK-TPMF 184
I P I+ T MF
Sbjct: 265 CICPFFIQATGMF 277
>At2g29370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 55.8 bits (133), Expect = 6e-08
Identities = 56/223 (25%), Positives = 94/223 (42%), Gaps = 15/223 (6%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNY-SFKMVELDVTK---DGSVATA 63
L+TG S G+G + E+L + G V +R Q + ++ L VT D S
Sbjct: 22 LVTGGSKGLGKAVVEELAMLGARVHTCARDETQLQESLREWQAKGLQVTTSVCDVSSRDQ 81
Query: 64 VAEVMKNA-----GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLP 118
++M+ GK+ +L+ N G+G+ E + E+ FI TNL +Q P
Sbjct: 82 REKLMETVSSLFQGKLSILVPNVGIGVL-KPTTECTAEEFSFIIATNLESTFHFSQLAHP 140
Query: 119 HMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHL 178
++ V + +IY A+K A+ L E + IR + + P
Sbjct: 141 LLKASGSGNIVLMSSVAGVVNLGNTSIYGATKGAMNQLARNLACEWASDNIRANSVCPWF 200
Query: 179 IKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVV 221
I TP +KD D+ + E+ T + + E+ E +S+V
Sbjct: 201 ITTPS-TKDFLGDKDVKEKVES----VTPLRRVGEANEVSSLV 238
>CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 427
Score = 55.5 bits (132), Expect = 8e-08
Identities = 55/233 (23%), Positives = 96/233 (40%), Gaps = 16/233 (6%)
Query: 5 KVVLITGASSGIG----LDIAEKLQ----LDGYEVFGTSRKGAQPNTNYSFKMVELDVTK 56
+ V+ITG SG+G LD A++ +D + G K D++
Sbjct: 42 QTVIITGGGSGLGRAMALDFAKRKAKVAIIDVNKEGGLETVKTIAAEGNMAKFWYCDISD 101
Query: 57 DGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
++ E+ G ++++I NA + +S+ + E S E + D N+FG + +A
Sbjct: 102 VDNMKKTAKEIEDTFGDVNIVICNAAI-LSFTSFMEISDELLRKCLDVNIFGTINTIRAF 160
Query: 117 LPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRN---QGIRVSV 173
LP M + G Y SK A+ E+L E+R+ +GI+ +
Sbjct: 161 LPKMETKNDGHIVCVCSIAGWSGETMGLSYCTSKFAVRGAMESLQMELRDRGLEGIKTTT 220
Query: 174 IDPHLIKTPM-FSKDLEPD---RPLSIYSETRKRLATSMEKQLESAEETSVVT 222
+ P+ +TPM ++ P P KR+ S+ K+ A S +T
Sbjct: 221 LYPYFARTPMILENNMRPTCTWFPFMSIRSCSKRMVDSILKEKVHAFVPSYIT 273
>At3g26760 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 55.5 bits (132), Expect = 8e-08
Identities = 47/190 (24%), Positives = 81/190 (41%), Gaps = 15/190 (7%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTS---RKGAQPNTNY--SFKMVELDVTKDGS 59
KV +ITG +SGIG AE+ G +V G T + + DVT++
Sbjct: 8 KVAVITGGASGIGKATAEEFVSQGAQVIIVDIDEEAGHMVATELGSAAHFLRCDVTEEEQ 67
Query: 60 VATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKF--IFDTN----LFGVMRMT 113
+A AV + GK+DV++N+AG+ S + + ++ + + N + G+
Sbjct: 68 IAKAVETAVTRHGKLDVMLNSAGISCSISPPSIADLDMDTYDKVMRLNVRGTVLGIKHAA 127
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
+A++P P A YS SK + + + E+ G+R++
Sbjct: 128 RAMIPAGSGSILCLSSISGLMGGLGPHA----YSISKFTIPGVVKTVASELCKHGLRINC 183
Query: 174 IDPHLIKTPM 183
I P I TP+
Sbjct: 184 ISPAGIPTPL 193
>At2g30670 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 55.5 bits (132), Expect = 8e-08
Identities = 57/204 (27%), Positives = 87/204 (41%), Gaps = 23/204 (11%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYS------FKMVE--LDVTKDGS 59
L+TG +SGIG I E+L G ++ N + S F++ DV+
Sbjct: 13 LVTGGASGIGHAIVEELAGLGARIYVCDISETLLNQSLSEWEKKGFQVSGSICDVSSHSE 72
Query: 60 VATAVAEVMKNA-GKIDVLINNAGV-----GISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
T + V K GK+++L+NN GV I + AA+ S F TNL ++
Sbjct: 73 RETLMQTVSKMFDGKLNILVNNVGVVNPKPTIEYVAADFS------FSISTNLESAYHLS 126
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
Q P ++ V + G+IYS +K AL + L E GIR +
Sbjct: 127 QLSHPLLKASEFGSIIFISSVGGVVSMECGSIYSLTKGALNQLAKTLACEWARDGIRANS 186
Query: 174 IDPHLIKTPM---FSKDLEPDRPL 194
+ P+ I T M F KD + ++ L
Sbjct: 187 VAPNFIYTAMAQPFFKDADYEKSL 210
>7294452 [Q] KOG1205 Predicted dehydrogenase
Length = 266
Score = 55.5 bits (132), Expect = 8e-08
Identities = 47/204 (23%), Positives = 82/204 (40%), Gaps = 18/204 (8%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK---------GAQPNTNYSFKMVELDV 54
NKV +++GAS+GIG L G V G +R+ G ++ D+
Sbjct: 20 NKVAVVSGASAGIGAACTRALIGAGMIVVGLARRHERVEKLRSGLSLEQQSRLHAIKCDI 79
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
T++ V A + G +DVL++NAG+ + +E + +TN+ G + +
Sbjct: 80 TQEDQVLKAFDWTCRQLGGVDVLVSNAGIIGTGELSERDDGPAMRSTIETNIMGTVYCVR 139
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVA-FGA------IYSASKHALEAYTEALDHEVRNQ 167
M+ + V G IY A+K AL A E E +
Sbjct: 140 ESFRSMKRRGTEGHVVIVNSVAGYQVPNLGPQLPSLNIYPATKFALRAMNEIYRQEFQRH 199
Query: 168 --GIRVSVIDPHLIKTPMFSKDLE 189
+RVS + P ++ T + + ++
Sbjct: 200 KTAVRVSTVSPGIVDTVILPEQIQ 223
>CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 296
Score = 55.1 bits (131), Expect = 1e-07
Identities = 53/196 (27%), Positives = 87/196 (44%), Gaps = 20/196 (10%)
Query: 1 MSSNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK--------GAQPNTNYSFKMVEL 52
M S+K+ ++TG SGIG I +K G + K G P +S E+
Sbjct: 53 MLSSKLAIVTGGGSGIGQAICKKFAASGARLIVADLKKSAAEATAGNLPGNGHS--AFEI 110
Query: 53 DVTKDGSVATAVAEVMKNAGKI-DVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
DV+ VA + E +K++G+ VL+N AG+ A + S Q + + + NL V
Sbjct: 111 DVSDPEHVAR-LQEFIKSSGESPSVLVNCAGITKD-ATLLKMSQNQWQDVMNVNLNSVFL 168
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAI----YSASKHALEAYTEALDHEVRNQ 167
M+Q + RE + G Y+A+K + +T++ E+ +
Sbjct: 169 MSQMIA---RESVAAGSPLSIVNVSSIVGKIGNFGQTNYAATKSGVIGFTKSAARELATK 225
Query: 168 GIRVSVIDPHLIKTPM 183
IRV+ + P I+TPM
Sbjct: 226 NIRVNAVLPGFIRTPM 241
>7301617_1 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 302
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/191 (24%), Positives = 85/191 (44%), Gaps = 18/191 (9%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ----PNTNYS-FKMVE------ 51
+ + + ITGAS GIG +IA K DG + ++ P T YS + +E
Sbjct: 8 AGRTLFITGASRGIGKEIALKAARDGANIVVAAKTAEPHPKLPGTIYSAAEEIEKAGGKA 67
Query: 52 ----LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLF 107
+DV + V +AV + G ID++INNA IS ++ +++ + + N
Sbjct: 68 YPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNAS-AISLTNTPDTDMKRYDLMHNINTR 126
Query: 108 GVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFG--AIYSASKHALEAYTEALDHEVR 165
G +++ LP++++ P FG Y+ +K+ + + E +
Sbjct: 127 GTFLVSKVCLPYLKKSNHAHILNISPPLSMKPKWFGPHVAYTMAKYGMSMCVLGMAAEFK 186
Query: 166 NQGIRVSVIDP 176
++GI V+ + P
Sbjct: 187 DEGISVNALWP 197
>SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 54.7 bits (130), Expect = 1e-07
Identities = 48/191 (25%), Positives = 86/191 (44%), Gaps = 11/191 (5%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQ-LDGYEVFGTSRK-GAQPN------TNYSFKMVELD 53
++NK+ I G + GIGL + ++L G VF ++RK GA ++ + +++LD
Sbjct: 3 TTNKIYFIAGGNRGIGLSLVKELSNRKGTVVFASARKPGAATKLQEWSKSHSNVHIIKLD 62
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
V+ S A EV K +DVL N+ V S+ + + + TN+ G + +
Sbjct: 63 VSSLESANEAAQEVTKVVDAVDVLWVNSAVFHSFGPVVNTPDDVWNSHYKTNVLGPIHVY 122
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAF---GAIYSASKHALEAYTEALDHEVRNQGIR 170
QA P +++ + F + Y SK AL + + E++++G
Sbjct: 123 QAFYPLIKKGRSKIIVFTSSLAGSMGAFFPSSQSAYGQSKAALNYTMKEISFELQDEGFI 182
Query: 171 VSVIDPHLIKT 181
V I P ++T
Sbjct: 183 VISIHPGAVRT 193
>CE13008 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 247
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/243 (25%), Positives = 100/243 (41%), Gaps = 16/243 (6%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVAT 62
S K V++TG+SSGIG A G +V T R + KM+++ + +V
Sbjct: 5 SGKSVIVTGSSSGIGRATAVLFAKYGAQVTITGRDAGKLEATKK-KMLKV-MKNPENVCV 62
Query: 63 AVA---------EVMKNA----GKIDVLINNAGVGI-SWAAAEESSIEQSKFIFDTNLFG 108
VA E++++A G+IDVL+NNAG + + S E F N
Sbjct: 63 VVANLTDSDGQDEIVQSALDAFGRIDVLVNNAGANVVDGTFNTDQSTELYHKTFQINFEA 122
Query: 109 VMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG 168
V+ M + H+ E +A Y+ASK AL+ YT + ++ QG
Sbjct: 123 VIEMVKKTKNHLIESKGEIVNVSSVAAGPQALAPSPYYAASKAALDQYTRCVALDLILQG 182
Query: 169 IRVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQLESAEETSVVTDTVLYS 228
I + E L I+ RKR + + + + + TS+V+ +
Sbjct: 183 IEENFTSNRACIPAGVCGKPEDIAELIIFLADRKRSSYIIGQSIVADGGTSLVSGLTAQN 242
Query: 229 LQQ 231
+Q+
Sbjct: 243 IQR 245
>CE15574 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 53.9 bits (128), Expect = 2e-07
Identities = 52/199 (26%), Positives = 88/199 (44%), Gaps = 20/199 (10%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVAT 62
S KV L+TG+S+GIG A L +G +V T R AQ +++ V +D V +
Sbjct: 5 SGKVALVTGSSNGIGRATAILLAREGAKVTITGRN-AQRLEETKQEILRSGVPED-HVLS 62
Query: 63 AVAEVMKNAGKI-------------DVLINNAGVGISWAAAEESSIEQSKFIFDT----N 105
+A++ +G+I D+L+NNAG I+ + + +FD N
Sbjct: 63 IIADLATESGQIELMNSTVDIFGRLDILVNNAGAAITDLEGH-IGVGTNVSVFDKTMRIN 121
Query: 106 LFGVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVR 165
L V+ +TQ H+ + Y+ SK AL+ YT + ++
Sbjct: 122 LRSVVTLTQKAKEHLIKTKGEIVNVSSIAGGQHAQPELIYYAMSKSALDQYTRSAAIDLI 181
Query: 166 NQGIRVSVIDPHLIKTPMF 184
G+RV+ + P I+T ++
Sbjct: 182 QHGVRVNSVSPGDIRTGIY 200
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 53.5 bits (127), Expect = 3e-07
Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 16/194 (8%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDG--SV 60
S KV L+TG+S+GIG A L +G +V T R + ++++ V +D S+
Sbjct: 5 SGKVALVTGSSNGIGRATAVLLAQEGAKVTITGRNADRLEETRQ-EILKSGVPEDHVLSI 63
Query: 61 ATAVA----------EVMKNAGKIDVLINNAGVGIS---WAAAEESSIEQSKFIFDTNLF 107
AT +A ++ G++D+L+NNAG + + + I N+
Sbjct: 64 ATDLATEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDRIMQINMR 123
Query: 108 GVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ 167
V+ +TQ H+ + Y+ SK AL+ YT + ++
Sbjct: 124 SVVTLTQKAKEHLVKAKGEVVNVSSIGAGPQAQPTFMYYAMSKAALDQYTRSAAIDLIQY 183
Query: 168 GIRVSVIDPHLIKT 181
G+RV+ + P + T
Sbjct: 184 GVRVNSVSPGAVVT 197
>CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 249
Score = 53.5 bits (127), Expect = 3e-07
Identities = 53/205 (25%), Positives = 87/205 (41%), Gaps = 26/205 (12%)
Query: 5 KVVLITGASSGIGLDIAEKL--QLDGYEVFGTSRKGAQPNTNYSFK-----MVELDVTKD 57
K +LITGA+ GIGL + ++ D + GT R + S K +++LD+ D
Sbjct: 4 KSILITGANRGIGLGLLKQFIKNKDVQIIIGTCRDPSNATELNSIKDTRVHILQLDIDCD 63
Query: 58 GSVATAVAEVMKNAGK--IDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
S+ AEV K G+ + VLINNAG+ + + E S +TN + +TQ
Sbjct: 64 DSIRKLGAEVEKLVGEDGLTVLINNAGIFVPYDIDGEKSRSTLIRQLETNTISTVLITQE 123
Query: 116 VLPHMR----EQXXXXXXXXXXXXXXVPVAFGAI-------------YSASKHALEAYTE 158
+LP ++ + + G+I Y SK AL ++ +
Sbjct: 124 LLPLLKRAAAKNRGEGYSINRSAIINISSTAGSITKIDASYNIPLVAYRMSKSALNSFGK 183
Query: 159 ALDHEVRNQGIRVSVIDPHLIKTPM 183
+ ++ I V+ P +KT M
Sbjct: 184 SCSVDLAKYHILVTTFCPGWVKTDM 208
>7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 278
Score = 53.1 bits (126), Expect = 4e-07
Identities = 47/202 (23%), Positives = 85/202 (41%), Gaps = 29/202 (14%)
Query: 5 KVVLITGASSGIGLDIAEKLQL------------DGYEVFGTSRKGAQPNTNYSFKMVEL 52
K ++TG + GIGL ++++L D E F + A P S ++++
Sbjct: 23 KNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEF-VKLRAAHPTQ--SVMIIKM 79
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
DV V E+ K G ID+++N AG+ + ++++ + NL G++
Sbjct: 80 DVANKKGVEATYEEIAKTFGNIDIVVNVAGI------FNDKDVQRTLLV---NLGGIINS 130
Query: 113 TQAVLPHMREQXXXXXXXXXXXXXXV---PVAFGAIYSASKHALEAYTEALDHE--VRNQ 167
T + LP+M + V P+ +Y A+K + +T L +E +
Sbjct: 131 TLSALPYMGKDNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRS 190
Query: 168 GIRVSVIDPHLIKTPMFSKDLE 189
GI+ + P T MF+ E
Sbjct: 191 GIKFVTVCPGATMTDMFTNFTE 212
>SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 341
Score = 52.8 bits (125), Expect = 5e-07
Identities = 47/193 (24%), Positives = 80/193 (41%), Gaps = 17/193 (8%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSR---------KGAQPNTNYSFKMVELDVTKDG 58
++TGA+ GIG + A +L + G+ V SR K + + + +D TK
Sbjct: 61 VVTGATDGIGKEYATQLAMSGFNVVLISRTQEKLDALAKELETVAKVKTRTIAIDYTKTT 120
Query: 59 SVATAVAEVMKNAGKIDVLINNAGVGISWAAA-EESSIEQSKFIFDTNLFGVMRMTQAVL 117
+ I VLINN G + E+++++ I N FG + T+AVL
Sbjct: 121 AETFEKLHQDLVGTPITVLINNVGQSHYMPTSFAETTVKEMDDIMHINCFGTLHTTKAVL 180
Query: 118 PHMREQXXXXXX-------XXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIR 170
M + +P + + Y+ SK L ++ +L EV+ QGI
Sbjct: 181 SIMLRERQKNEKGPRCLILTMGSFAGLLPSPYLSTYAGSKAFLSNWSASLGEEVKKQGID 240
Query: 171 VSVIDPHLIKTPM 183
V + +L+ + M
Sbjct: 241 VWCFNSYLVVSAM 253
>At2g29360 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 271
Score = 52.8 bits (125), Expect = 5e-07
Identities = 47/195 (24%), Positives = 76/195 (38%), Gaps = 20/195 (10%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVAEV 67
L+TG S GIG + E+L G + +R Q + + K V T+V +V
Sbjct: 22 LVTGGSKGIGEAVVEELATLGARIHTCARDETQLQES-----LRKWQAKGFQVTTSVCDV 76
Query: 68 MKN--------------AGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
GK+++L+NN G I + ++ E F TNL ++
Sbjct: 77 SSRDKREKLMETVSTIFEGKLNILVNNVGTCIVKPTLQHTA-EDFSFTMATNLESAFHLS 135
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSV 173
Q P ++ V V +IY SK A+ L E + IR +
Sbjct: 136 QLAHPLLKASGSGSIVLISSVSGVVHVNGASIYGVSKGAMNQLGRNLACEWASDNIRTNS 195
Query: 174 IDPHLIKTPMFSKDL 188
+ P I+TP+ ++ L
Sbjct: 196 VCPWFIETPLVTESL 210
>CE21093 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 281
Score = 52.4 bits (124), Expect = 7e-07
Identities = 47/199 (23%), Positives = 79/199 (39%), Gaps = 26/199 (13%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDG---- 58
S KV L+TG+S+GIG A DG +V T R + + ++ K G
Sbjct: 6 SGKVALVTGSSNGIGRAAAVLFAKDGAKVTVTGRNAER------LEETRQEILKSGVPES 59
Query: 59 ---SVATAVA----------EVMKNAGKIDVLINNAGVGIS---WAAAEESSIEQSKFIF 102
SVAT +A ++ G++D+L+NNAG + + + I
Sbjct: 60 HVLSVATDLAAEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDKIM 119
Query: 103 DTNLFGVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDH 162
N+ V+ +TQ H+ + Y+ SK AL+ +T
Sbjct: 120 QINMRSVVTLTQKAKEHLVKAKGEIVNVSSIAGTAHAQPGVMYYAMSKSALDQFTRCAAI 179
Query: 163 EVRNQGIRVSVIDPHLIKT 181
++ G+RV+ + P + T
Sbjct: 180 DLIQYGVRVNSVSPGGVTT 198
>At3g61220 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 52.0 bits (123), Expect = 9e-07
Identities = 37/146 (25%), Positives = 61/146 (41%), Gaps = 29/146 (19%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSR------------KGAQPNTNYSFKMVEL 52
+ ++TGA+ GIG +I +L +G V TSR K ++ S +L
Sbjct: 7 RYAVVTGANRGIGFEICRQLASEGIRVVLTSRDENRGLEAVETLKKELEISDQSLLFHQL 66
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGV-----------------GISWAAAEESSI 95
DV S+ + V GK+D+L+NNAG+ G W +
Sbjct: 67 DVADPASITSLAEFVKTQFGKLDILVNNAGIGGIITDAEALRAGAGKEGFKWDEIITETY 126
Query: 96 EQSKFIFDTNLFGVMRMTQAVLPHMR 121
E ++ N +G RM +A +P ++
Sbjct: 127 ELTEECIKINYYGPKRMCEAFIPLLK 152
>At2g24190 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 52.0 bits (123), Expect = 9e-07
Identities = 40/145 (27%), Positives = 60/145 (40%), Gaps = 29/145 (20%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ------------PNTNYSFKMV 50
S + ++TG + GIG +I +L G V TSR Q ++ S
Sbjct: 5 SPRYAIVTGGNRGIGFEICRQLANKGIRVILTSRDEKQGLEAVETLKKELEISDQSIVFH 64
Query: 51 ELDVTKDGSVATAVAEVMKNAGKIDVLINNAGV-----------------GISWAAAEES 93
+LDV+ SV + V + GK+D+LINNAGV G W
Sbjct: 65 QLDVSDPVSVTSLAEFVKTHFGKLDILINNAGVGGVITDVDALRAGTGKEGFKWEETITE 124
Query: 94 SIEQSKFIFDTNLFGVMRMTQAVLP 118
+ E ++ N +G RM +A +P
Sbjct: 125 TYELAEECIKINYYGPKRMCEAFIP 149
>CE02786 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 305
Score = 51.6 bits (122), Expect = 1e-06
Identities = 47/182 (25%), Positives = 77/182 (41%), Gaps = 11/182 (6%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSV---A 61
K V I+G SG G +A +L G + +K + +F + L+V D SV
Sbjct: 20 KTVAISGCDSGFGRLLAVRLVKQGVPNGESLKKEVNTPSLLTFGI--LNVANDESVKEFV 77
Query: 62 TAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFI--FDTNLFGVMRMTQAVLPH 119
V + ++N G V+ N GI + + + +I N FGVMR Q +
Sbjct: 78 KLVEKTVENRGLWGVVAN---AGILGNSGPDDWLSAQDYINTMQVNTFGVMRFIQGLKKF 134
Query: 120 MREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHLI 179
+++Q G Y SKHA+EAY + + HE+ + + V +++P
Sbjct: 135 VKKQEGRVVIISSISGRTPRPTVGP-YCVSKHAVEAYADVIRHELIDFNVSVHLLEPGFF 193
Query: 180 KT 181
T
Sbjct: 194 TT 195
>CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 333
Score = 51.6 bits (122), Expect = 1e-06
Identities = 47/189 (24%), Positives = 74/189 (38%), Gaps = 13/189 (6%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPN----------TNYSFKMVELDVTKD 57
++TGA+ GIG A +L G+ V SR ++ + ++ + D T
Sbjct: 68 VVTGATDGIGKAYAFELARRGFNVLLVSRTQSKLDETKKEILEKYSSIEVRTAAFDFTNA 127
Query: 58 GSVATAVAEVMKNAGKIDVLINNAGVGISWAAA---EESSIEQSKFIFDTNLFGVMRMTQ 114
A N +I VLINN G+ + + IE+ I N ++
Sbjct: 128 APSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIERLANITTINTLPPTLLSA 187
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVI 174
+LP M + +A A+YSA+K + T L E +QGI V I
Sbjct: 188 GILPQMVARKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRKEYEHQGITVQTI 247
Query: 175 DPHLIKTPM 183
P ++ T M
Sbjct: 248 APMMVATKM 256
>At3g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 259
Score = 51.6 bits (122), Expect = 1e-06
Identities = 53/204 (25%), Positives = 84/204 (40%), Gaps = 15/204 (7%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTS-RKGAQPNTNYSFKM-----VELDVTKDG 58
K+V+ITG +SGIG + A G +V ++ N S + D+T +
Sbjct: 9 KIVIITGGASGIGAEAARLFTDHGAKVVIVDLQEELGQNVAVSIGLDKASFYRCDITDET 68
Query: 59 SVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLP 118
V AV ++ GK+DVL +NAGV + + +E FD + +R A +
Sbjct: 69 EVENAVKFTVEKHGKLDVLFSNAGVMEPHGSILDLDLE----AFDRTMAVNVRGAAAFIK 124
Query: 119 H-MREQXXXXXXXXXXXXXXVPVAFGA----IYSASKHALEAYTEALDHEVRNQGIRVSV 173
H R V G Y+ASKHAL + + GIRV+
Sbjct: 125 HAARSMVASGTRGSIVCTTSVTAEIGGPGPHSYTASKHALLGLVRSACGGLGKYGIRVNG 184
Query: 174 IDPHLIKTPMFSKDLEPDRPLSIY 197
+ P+ + T + S + E + + Y
Sbjct: 185 VAPYGVATGLTSYNEETVKMVEDY 208
>At2g29340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 51.6 bits (122), Expect = 1e-06
Identities = 48/192 (25%), Positives = 80/192 (41%), Gaps = 12/192 (6%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVA-- 65
L+TG +SGIG I E+L G + A+ N + S + + GSV +
Sbjct: 13 LVTGGASGIGYAIVEELAGFGARIHVCDISEAKLNQSLS-EWEKKGFQVSGSVCDVASRP 71
Query: 66 ---EVMKNA-----GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVL 117
E+M+ GK+++L++N GV I E + + F +N+ +Q
Sbjct: 72 EREELMQTVSSQFDGKLNILVSNVGV-IRSKPTTEYTEDDFAFHISSNVEAAYHFSQLSH 130
Query: 118 PHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPH 177
P ++ + G+IY +K AL + L E GIR + + P+
Sbjct: 131 PLLKASGYGSIIFVSSIAGVISFDAGSIYGLTKGALIQLAKNLACEWAKDGIRANAVAPN 190
Query: 178 LIKTPMFSKDLE 189
+I TP+ LE
Sbjct: 191 VINTPLSQSYLE 202
>Hs10047132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 245
Score = 51.2 bits (121), Expect = 1e-06
Identities = 52/215 (24%), Positives = 92/215 (42%), Gaps = 15/215 (6%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVE---LDVTKDGSVA 61
KV+++T A+ GIG A +G +V T ++ + ++ LDVTK +
Sbjct: 7 KVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEKYPGIQTRVLDVTKKKQID 66
Query: 62 TAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLPHMR 121
EV + +DVL N AG + + + F + N+ + M +A LP M
Sbjct: 67 QFANEVER----LDVLFNVAGF-VHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKML 121
Query: 122 EQXXXXXXXXXXXXXXVP-VAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHLIK 180
Q V V +YS +K A+ T+++ + QGIR + + P +
Sbjct: 122 AQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVD 181
Query: 181 TPMFSKDLE----PDRPLSIYSETRK--RLATSME 209
TP + ++ P+ + + + +K R AT+ E
Sbjct: 182 TPSLQERIQARGNPEEARNDFLKRQKTGRFATAEE 216
>At5g04900 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 341
Score = 51.2 bits (121), Expect = 1e-06
Identities = 53/194 (27%), Positives = 79/194 (40%), Gaps = 14/194 (7%)
Query: 7 VLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVEL---------DVTKD 57
+LITG++ GIG +A + G V SR + T E DVT+
Sbjct: 82 ILITGSTKGIGYALAREFLKAGDNVVICSRSAERVETAVQSLKEEFGEHVWGTKCDVTEG 141
Query: 58 GSVATAVAEVMKNAGKIDVLINNAGV-GISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
V VA KN ID+ INNAG S+ E+S E + TN G+M +
Sbjct: 142 KDVRELVAYSQKNLKYIDIWINNAGSNAYSFKPLAEASDEDLIEVVKTNTLGLMLCCREA 201
Query: 117 LPHMREQX--XXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVI 174
+ M Q P A Y A+K ++ T++L E++ Q ++ V+
Sbjct: 202 MNMMLTQSRGGHIFNIDGAGSDGRPTPRFAAYGATKRSVVHLTKSLQAELQMQDVKNVVV 261
Query: 175 DPHLIKTPMFSKDL 188
H + M + DL
Sbjct: 262 --HNLSPGMVTTDL 273
>7303531 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 388
Score = 51.2 bits (121), Expect = 1e-06
Identities = 66/269 (24%), Positives = 110/269 (40%), Gaps = 35/269 (13%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFG---------TSRKGAQPNTNYSFKMVEL 52
+S K VLITG + + +A+KL G+ V+ K + T+ K++ L
Sbjct: 93 ASGKGVLITGCEAPLAWYLAKKLDDLGFTVYAGFNTPIEESDEAKILKEVTSGRMKLLHL 152
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFI-----FDTNLF 107
DVT + ++ A V ++ + + W A E +E F D NL
Sbjct: 153 DVTSEKTILEAARYVSQHLPHGAEGLWSVVHCAHWIALGE--LEWIPFAVLRKSLDLNLL 210
Query: 108 GVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ 167
G R+TQ LP +R + VP I A++ A++ + L E+R +
Sbjct: 211 GSARLTQIFLPLVR-RAHGRVVFLTSGLNRVPSPVRGIQCATQAAVDCFAACLRQEMRTR 269
Query: 168 GIRVSVI--------DPHLIKTPMFSKDLEPDRPLSIYSETRKRLA--------TSMEKQ 211
G+ VSV+ + L +T + + + LS SE +K TS+EK
Sbjct: 270 GVDVSVVAAGEFAPGNGWLNETELRDQAKQMWNQLS--SEQKKTYGEDYYEAAMTSVEKY 327
Query: 212 LESAEETSVVTDTVLYSLQQTAPHIRYTP 240
A + ++ ++ +T P RYTP
Sbjct: 328 SRQAADIQPTLRVLIDAVTRTFPMARYTP 356
>7295622 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 51.2 bits (121), Expect = 1e-06
Identities = 49/197 (24%), Positives = 81/197 (40%), Gaps = 20/197 (10%)
Query: 4 NKVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQ---------PNTNYSFKMVELDV 54
++V ++TGASSGIG +A L G V G +R+ + P + DV
Sbjct: 6 DRVAVVTGASSGIGAAVARHLVSAGVIVVGLARRVDRMKAIKEQLPPELQGRLHAIHCDV 65
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
SV A + + G D+L+NNAG ++ +EQ + + + NL GV+ T+
Sbjct: 66 EDLDSVTAAFDWIEEQLGGCDILVNNAGC-LNPGQLLTLELEQLQQVLNVNLMGVVICTR 124
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGA--------IYSASKHALEAYTEALDHEVR- 165
M+++ + +Y +KH + A E L E+R
Sbjct: 125 RAFRSMQQREVDGHVILINSLTGRNIINPPGDELQVLNMYPLTKHGVTAMLEVLRQELRG 184
Query: 166 -NQGIRVSVIDPHLIKT 181
I+V+ I P + T
Sbjct: 185 FKTKIKVTSITPGVTDT 201
>SPBC16H5.14c [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 286
Score = 50.8 bits (120), Expect = 2e-06
Identities = 53/196 (27%), Positives = 84/196 (42%), Gaps = 10/196 (5%)
Query: 6 VVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNT----NYSFKMVELDVTKDGSVA 61
+++ITG S +G I ++ G+ V S +P + N F ++ ++TKD V
Sbjct: 37 LIVITGGSGILGHAIIQEALDRGFSV--ASLDSTEPASFLQYNSKFSALKCNITKDKDVE 94
Query: 62 TAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLPHMR 121
V + K LIN A + S E K F+TN+ G + +T A+ P +
Sbjct: 95 GCVHSLKKMNRTPFALINAAAIAPKNHLLSISRQELQK-CFETNVIGQLAITSALFPLLL 153
Query: 122 EQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ--GIRVSVIDPHLI 179
+ YS+SK AL + E L+ EV +Q + S+ I
Sbjct: 154 QDPNPHVVNIASSLAYFSAMGVGAYSSSKAALVSLHETLEEEVLSQHPNFKFSLYVLGQI 213
Query: 180 KTPMFSKDLEPDRPLS 195
K+ MF KD P+R L+
Sbjct: 214 KSTMFEKD-TPNRVLA 228
>CE03613 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 262
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/216 (23%), Positives = 83/216 (37%), Gaps = 31/216 (14%)
Query: 5 KVVLITGASSGIGLDIAEKL-QLDGYEVFGTSRKGAQP--------NTNYSFKMVELDVT 55
K V ITGA+ GIGL I KL ++ EV + + + + +DV
Sbjct: 4 KTVFITGANRGIGLGIVRKLLKVSEIEVIIAGARNLEAANELRELAKADNRLHAITVDVA 63
Query: 56 KDGSVATAVAEVMKNAGK--IDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
D +A +V +V G +++LINNAG + + S + S FD N G + +
Sbjct: 64 NDERLANSVKQVESLVGDRGLNLLINNAGCYELYETTDSPSRKASLKCFDVNAVGSLMAS 123
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGA------------------IYSASKHALEA 155
Q LP +++ + G+ Y SK A+ +
Sbjct: 124 QLFLPLLKKAAAHTHITGLSASRAAILNIGSDCSSQFLNGTPTVNDVSIAYKMSKVAMLS 183
Query: 156 YTEAL--DHEVRNQGIRVSVIDPHLIKTPMFSKDLE 189
+ +L D N + ++ I P + T M D E
Sbjct: 184 FARSLASDFRTLNIPVLIATIHPGWVLTEMGGSDAE 219
>At2g37540 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 321
Score = 50.8 bits (120), Expect = 2e-06
Identities = 53/215 (24%), Positives = 88/215 (40%), Gaps = 35/215 (16%)
Query: 2 SSNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR--KGA--------QPNTNYSFKMVE 51
+S+ +ITG +SGIGL+ A L + G V +R K A Q N N ++
Sbjct: 31 ASHLTAIITGGTSGIGLEAARVLAMRGAHVIIAARNPKAANESKEMILQMNPNARVDYLQ 90
Query: 52 LDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMR 111
+DV+ SV + V + + +++LINNAGV E IE F TN G
Sbjct: 91 IDVSSIKSVRSFVDQFLALNVPLNILINNAGVMFCPFKLTEDGIESQ---FATNHIGHFL 147
Query: 112 MTQAVLPHMRE---------QXXXXXXXXXXXXXXVPVAFGAI-----------YSASKH 151
+T +L M+ + + F I Y SK
Sbjct: 148 LTNLLLDKMKSTARESGVQGRIVNLSSIAHTYTYSEGIKFQGINDPAGYSERRAYGQSKL 207
Query: 152 ALEAYTEALDHEVRNQGIRVSV--IDPHLIKTPMF 184
+ ++ AL ++ +G+ +++ + P L+ T +F
Sbjct: 208 SNLLHSNALSRRLQEEGVNITINSVHPGLVTTNLF 242
>7300387 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 50.8 bits (120), Expect = 2e-06
Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 12/128 (9%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNT----------NYSFKMVELDV 54
K V+ITGA+SGIG + A+ L G + R N N + +LD+
Sbjct: 34 KTVIITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKETKNNKILVKKLDL 93
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
SV A+++K KIDVLI+NAG+ +++ ++S + + TN +G +T
Sbjct: 94 GSQKSVREFAADIVKTEPKIDVLIHNAGMALAFRG--QTSEDGVELTMATNHYGPFLLTH 151
Query: 115 AVLPHMRE 122
++ +++
Sbjct: 152 LLIDVLKK 159
>Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 309
Score = 50.4 bits (119), Expect = 3e-06
Identities = 44/186 (23%), Positives = 74/186 (39%), Gaps = 11/186 (5%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSR---------KGAQPNTNYSFKMVELDVTKDG 58
+++GA+ GIG AE+L G + SR K ++ D +
Sbjct: 50 VVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSGR 109
Query: 59 SVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKF-IFDTNLFGVMRMTQAVL 117
+ + E +K+ + +L+NN GV + E + I + N+ M VL
Sbjct: 110 EIYLPIREALKDKD-VGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVL 168
Query: 118 PHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPH 177
P M E+ P A +SASK L+ ++ AL +E ++GI V + P
Sbjct: 169 PGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPF 228
Query: 178 LIKTPM 183
+ M
Sbjct: 229 YVAASM 234
>At4g03140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 283
Score = 50.4 bits (119), Expect = 3e-06
Identities = 54/202 (26%), Positives = 77/202 (37%), Gaps = 20/202 (9%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTS-----RKGAQPNTNYSFKMVELDVTKDGS 59
KV LITG +SGIG A K G +V + + S DVTK+
Sbjct: 21 KVALITGGASGIGKATAGKFISHGAKVIIADIQPQIGRETEQELGPSCAYFPCDVTKESD 80
Query: 60 VATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFD----TNLFGVMRMTQA 115
+A AV + K+D++ NNAG+ S ++ +FD TN+ GVM A
Sbjct: 81 IANAVDFAVSLHTKLDIMYNNAGIP---CKTPPSIVDLDLNVFDKVINTNVRGVM----A 133
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAI----YSASKHALEAYTEALDHEVRNQGIRV 171
+ H V G + YS SK A+ + E+ IRV
Sbjct: 134 GIKHAARVMIPRNSGSIICAGSVTGMMGGLAQHTYSVSKSAVIGIVRSTASELCKHRIRV 193
Query: 172 SVIDPHLIKTPMFSKDLEPDRP 193
+ I P I T ++ P
Sbjct: 194 NCISPFAITTSFVMDEMRQIYP 215
>At2g29330 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 50.4 bits (119), Expect = 3e-06
Identities = 48/192 (25%), Positives = 73/192 (38%), Gaps = 12/192 (6%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVAEV 67
L+TG +SGIG I E+L G ++ N + S + + GSV A +
Sbjct: 13 LVTGGASGIGHAIVEELAGFGAKIHVCDISKTLLNQSLS-EWEKKGFQVSGSVCDASNRL 71
Query: 68 MKNA----------GKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVL 117
+ GK+++L+NN G I E E F+ TNL ++Q
Sbjct: 72 ERETLMQTVTTIFDGKLNILVNNVGT-IRTKPTIEYEAEDFSFLISTNLESAYHLSQLSH 130
Query: 118 PHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPH 177
P ++ V +IY +K AL L E GIR + + P+
Sbjct: 131 PLLKASGNGIITFISSAAGIVSFDAASIYGLTKGALNQLARNLACEWAKDGIRANAVAPN 190
Query: 178 LIKTPMFSKDLE 189
I T + LE
Sbjct: 191 FITTALAKPFLE 202
>7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 325
Score = 50.4 bits (119), Expect = 3e-06
Identities = 49/195 (25%), Positives = 85/195 (43%), Gaps = 13/195 (6%)
Query: 3 SNKVVLITGASSGIGLDIA---EKLQLD------GYEVFGTSRKGAQPNTNYSFKMVELD 53
S +VVLITG G+G IA +LQ E T+ + + K +D
Sbjct: 55 SGQVVLITGGGGGVGRLIALNFARLQARIVIWDINQEAIKTTVDLLAKHGYDNCKGYVVD 114
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
++ + ++V + G +D+LINNAG+ + E + ++ N+
Sbjct: 115 ISDREQIYQRASQVTEEVGPVDILINNAGI-VCCKPFWELHDRVIQNTYNINIISHYWTV 173
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQG---IR 170
+A LPHM + + Y+A+K+A + E+L +++ G I+
Sbjct: 174 KAFLPHMMRNNRGHIVTVGSVTGMLGTYGCSDYAATKYACIGFHESLLTDLKAHGYDQIQ 233
Query: 171 VSVIDPHLIKTPMFS 185
+S+I P+ I T MFS
Sbjct: 234 MSLICPYYINTGMFS 248
>7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 321
Score = 50.4 bits (119), Expect = 3e-06
Identities = 45/192 (23%), Positives = 81/192 (41%), Gaps = 20/192 (10%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNT---------NYSFKMVELDVTKDG 58
++TG++ GIG A++L G ++ SR + N +++++D T
Sbjct: 56 VVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGD 115
Query: 59 SVATAVAEVMKNAG-KIDVLINNAGVGISWAAAE------ESSIEQSKFIFDTNLFGVMR 111
+ + E K G + VL+NN VGIS+ E ++ + I N+ V
Sbjct: 116 EIYDKIRE--KTTGLNVGVLVNN--VGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTH 171
Query: 112 MTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRV 171
MT LP M Q +P ++YS++K + +++ L E + GI +
Sbjct: 172 MTALFLPGMISQRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILI 231
Query: 172 SVIDPHLIKTPM 183
+ P + T M
Sbjct: 232 QSVQPGFVATNM 243
>At3g29250 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 50.1 bits (118), Expect = 3e-06
Identities = 59/226 (26%), Positives = 93/226 (41%), Gaps = 20/226 (8%)
Query: 5 KVVLITGASSGIGLDI--------AEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTK 56
K+ +ITG +SGIG + A+ + +D E G + + SF +VT
Sbjct: 9 KIAIITGGASGIGAEAVRLFTDHGAKVVIVDIQEELGQNLAVSIGLDKASF--YRCNVTD 66
Query: 57 DGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAV 116
+ V AV ++ GK+DVL +NAGV ++ + + +E FD + +R A
Sbjct: 67 ETDVENAVKFTVEKHGKLDVLFSNAGVLEAFGSVLDLDLE----AFDRTMAVNVRGAAAF 122
Query: 117 LPH-MREQXXXXXXXXXXXXXXVPVAFGA----IYSASKHALEAYTEALDHEVRNQGIRV 171
+ H R + G Y+ASKHAL + + GIRV
Sbjct: 123 IKHAARSMVASGTRGSIVCTTSIAAEIGGPGPHSYTASKHALLGLIRSACAGLGQYGIRV 182
Query: 172 SVIDPHLIKTPMFSK-DLEPDRPLSIYSETRKRLATSMEKQLESAE 216
+ + P+ + T M S + E + L Y E L + K AE
Sbjct: 183 NGVAPYGVATGMTSAYNEEAVKMLEEYGEALGNLKGVVLKARHIAE 228
>7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 339
Score = 50.1 bits (118), Expect = 3e-06
Identities = 41/188 (21%), Positives = 78/188 (40%), Gaps = 15/188 (7%)
Query: 8 LITGASSGIGLDIAEKLQLDGYEVFGTSR---------KGAQPNTNYSFKMVELDVTKDG 58
++TGA+ GIG + A +L G + SR + K + D K
Sbjct: 74 VVTGATDGIGKEYARELARQGINLVLISRTKEKLIAVTNEIESQYKVKTKWIAADFAKGR 133
Query: 59 SVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFD---TNLFGVMRMTQA 115
V + + + + +L+NN VG+ + E + +++ N+ V +T+
Sbjct: 134 EVYDQIEKELAGID-VGILVNN--VGMMYEHPESLDLVSEDLLWNLLTVNMGSVTMLTRK 190
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVID 175
+LP M + P+ +Y+ASK + +++AL+ EV I V ++
Sbjct: 191 ILPQMIGRRKGAIVNLGSSSELQPLPNMTVYAASKKFVTYFSKALELEVAEHNIHVQLVM 250
Query: 176 PHLIKTPM 183
P+ + T M
Sbjct: 251 PNFVVTKM 258
>7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 320
Score = 50.1 bits (118), Expect = 3e-06
Identities = 47/192 (24%), Positives = 82/192 (42%), Gaps = 15/192 (7%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVF---------GTSRKGAQPNTNYSFKMVELD 53
+ KVVLITG G+G ++A + G + + K + N +F V +
Sbjct: 57 NGKVVLITGTGHGMGKEMALQYAKLGATILCWDVNEQTNNQTVKEIKNNGGKAFGYV-CN 115
Query: 54 VTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
VTK + +V K G I V++NNAG+ E + + + +++ N+ +
Sbjct: 116 VTKREELIELAQKVRKEHGFIHVVVNNAGIMPCHPLLEHTE-NEIRLMYEINVLSHFWII 174
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQ----GI 169
QA LP M E+ + Y +K A+ Y AL E+R + +
Sbjct: 175 QAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAALVEELRQKNPQNNV 234
Query: 170 RVSVIDPHLIKT 181
+++ I P++I T
Sbjct: 235 KLTTIYPYMIDT 246
>CE08181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 333
Score = 49.7 bits (117), Expect = 4e-06
Identities = 49/207 (23%), Positives = 86/207 (40%), Gaps = 33/207 (15%)
Query: 6 VVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPN-------------TNYSFKMVEL 52
V ++TG++ GIG + +L L +V+ R + N T F +E
Sbjct: 48 VAVVTGSNCGIGFETVRELNLRKADVYMLCRSEEKANEAKRMLVRQGCDATRLHF--IEC 105
Query: 53 DVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRM 112
D+T SV A E +++ ID+LINNA GI + + E + + + + +N G +
Sbjct: 106 DLTDFESVRRAAKETLESTDTIDILINNA--GIMFQSKHEQTKDGHEKTWQSNHLGPFLL 163
Query: 113 TQAVLPHMREQXXXXXXXXXX-----------XXXXVPVAFGAI--YSASKHALEAYTEA 159
T+ LP +++ +FG + Y SK A + A
Sbjct: 164 TELFLPAVKKSSYARIINVSSRIHLKSEKINLATVDDKKSFGMMKSYRQSKLANVMHARA 223
Query: 160 LDHEVRNQG---IRVSVIDPHLIKTPM 183
L E+R G + V+ + P ++ T +
Sbjct: 224 LTKELRKDGAEHVTVNSLHPGVVNTEL 250
>CE26808_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 550
Score = 49.7 bits (117), Expect = 4e-06
Identities = 44/190 (23%), Positives = 72/190 (37%), Gaps = 18/190 (9%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDGYEVFGTSR-------------KGAQPNTNYSFKM 49
S KV L+TG+S+GIG A G +V T R K P N
Sbjct: 220 SGKVALVTGSSNGIGRAAALLFAQQGAKVTITGRNAERLEETRQAILKSGVPAENVL--A 277
Query: 50 VELDVTKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAE---ESSIEQSKFIFDTNL 106
+ D+ D + ++ G++D+L+NNAG ++ + IE F N+
Sbjct: 278 IAADLATDQGQTDLINGTLQKFGRLDILVNNAGAAVNDPQGRMGIDQQIEDFDKTFQINM 337
Query: 107 FGVMRMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRN 166
V+ + Q H+ + Y SK AL+ +T + +
Sbjct: 338 RSVVTLVQKAKEHLIKTKGEIINVSSIGGGPHAQPDMMYYGMSKAALDQFTRSTAITLIQ 397
Query: 167 QGIRVSVIDP 176
G+RV+ + P
Sbjct: 398 HGVRVNSVSP 407
>Hs7705925 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 244
Score = 49.3 bits (116), Expect = 6e-06
Identities = 45/178 (25%), Positives = 76/178 (42%), Gaps = 2/178 (1%)
Query: 7 VLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVATAVAE 66
VL+TGA GIG + L G V SR A ++ V D A
Sbjct: 10 VLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATER 69
Query: 67 VMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLPHMREQXXX 126
+ + G +D+L+NNA V + E + E F+ NL V++++Q V + +
Sbjct: 70 ALGSVGPVDLLVNNAAVALLQPFLEVTK-EAFDRSFEVNLRAVIQVSQIVARGLIARGVP 128
Query: 127 XXXXXXXXXXXV-PVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHLIKTPM 183
V ++Y ++K AL+ T+ + E+ IRV+ ++P ++ T M
Sbjct: 129 GAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSM 186
>CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 307
Score = 49.3 bits (116), Expect = 6e-06
Identities = 50/193 (25%), Positives = 79/193 (40%), Gaps = 16/193 (8%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEV--FGTSRKGAQPNTNYSFK--------MVELDV 54
K VLITG+ SGIG +A + G EV + ++ GA+ N K +V+L
Sbjct: 40 KKVLITGSGSGIGRLMALEFAKLGAEVVIWDVNKDGAEETKNQVVKAGGKASTFVVDLSQ 99
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQ 114
KD + E + G ID+LINNAG+ ++ + E + N + +
Sbjct: 100 YKD--IHKVAKETKEAVGDIDILINNAGI-VTGKKLFDCPDELMEKTMAVNTNALFYTAK 156
Query: 115 AVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEV---RNQGIRV 171
LP M E+ Y ASKH +++ E+ + G+
Sbjct: 157 NFLPSMLEKDNGHLVTIASMAGKTGCVGLVDYCASKHGAIGCHDSIAMEILAQKKYGVNT 216
Query: 172 SVIDPHLIKTPMF 184
+++ P I T MF
Sbjct: 217 TLVCPFFIDTGMF 229
>Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 300
Score = 48.9 bits (115), Expect = 7e-06
Identities = 45/192 (23%), Positives = 79/192 (40%), Gaps = 16/192 (8%)
Query: 3 SNKVVLITGASSGIG-------LDIAEKLQLDGYEVFGTSRKGAQ-PNTNYSFKMVELDV 54
+ ++VLITGA GIG + KL L G A+ +D
Sbjct: 35 TGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDC 94
Query: 55 TKDGSVATAVAEVMKNAGKIDVLINNAGVGIS--WAAAEESSIEQSKFIFDTNLFGVMRM 112
+ + ++ +V G + +L+NNAGV + A ++ IE++ F+ N+
Sbjct: 95 SNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKT---FEVNVLAHFWT 151
Query: 113 TQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHE---VRNQGI 169
T+A LP M + V V F Y +SK A + + L E ++ G+
Sbjct: 152 TKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGV 211
Query: 170 RVSVIDPHLIKT 181
+ + + P+ + T
Sbjct: 212 KTTCLCPNFVNT 223
>Hs14754051 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 245
Score = 48.9 bits (115), Expect = 7e-06
Identities = 51/215 (23%), Positives = 91/215 (41%), Gaps = 15/215 (6%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVE---LDVTKDGSVA 61
KV+++T A+ GIG A +G +V T ++ + ++ LDVTK +
Sbjct: 7 KVIILTAAAQGIGQAAALAFVREGAKVIATDINVSKLQELEKYLGIQTRVLDVTKKKQID 66
Query: 62 TAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVLPHMR 121
EV + +DVL N AG + + + F + N+ M +A LP M
Sbjct: 67 QFANEVER----LDVLFNVAGF-VHHGTVLDCEEKDWDFSMNLNVRSTYLMIKAFLPKML 121
Query: 122 EQXXXXXXXXXXXXXXVP-VAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVIDPHLIK 180
Q + V +YS +K A+ T+++ + QGIR + + P +
Sbjct: 122 AQKSGNIITMFSVVSSIKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGIRCNCVCPGTVD 181
Query: 181 TPMFSKDLE----PDRPLSIYSETRK--RLATSME 209
TP + ++ P+ + + + +K R AT+ E
Sbjct: 182 TPSLQERIQARGNPEEARNDFLKRQKMGRFATAEE 216
>CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 48.9 bits (115), Expect = 7e-06
Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 27/208 (12%)
Query: 7 VLITGASSGIGLDIAEKLQLDGY--EVFGTSRKGAQPNTNYSFK-----MVELDVTKDGS 59
V++TGA+ GIGL + ++L D + T+R + S K ++ L VT D S
Sbjct: 6 VVVTGANRGIGLGLVQQLVKDKNIRHIIATARDVEKATELKSIKDSRVHVLPLTVTCDKS 65
Query: 60 VATAVAEVMKNAGK--IDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQAVL 117
+ T V++V + G + +LINNAGV +S+ E + D N V+ +TQ +L
Sbjct: 66 LDTFVSKVGEIVGSDGLSLLINNAGVLLSYGTNTEPNRAVIAEQLDVNTTSVVLLTQKLL 125
Query: 118 PHMR----EQXXXXXXXXXXXXXXVPVAFGAI--------------YSASKHALEAYTEA 159
P ++ ++ + G+I Y SK A+ +
Sbjct: 126 PLLKNAASKESGDQLSVSRAAVITISSGLGSITDNTSGSAQFPVLAYRMSKAAINMFGRT 185
Query: 160 LDHEVRNQGIRVSVIDPHLIKTPMFSKD 187
L ++++ + V P ++T + K+
Sbjct: 186 LAVDLKDDNVLVVNFCPGWVQTNLGGKN 213
>CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 48.9 bits (115), Expect = 7e-06
Identities = 51/235 (21%), Positives = 98/235 (41%), Gaps = 32/235 (13%)
Query: 3 SNKVVLITGASSGIGLDIAEKLQLDG--YEVFGTSRKGAQPN-----TNYSFKMVELDVT 55
S K V+ITGA+ GIGL + ++ D + T+R + ++ ++L+VT
Sbjct: 2 SPKSVVITGANRGIGLGLVQEFVKDKNIRHIIATARDVEKATDLKAISDPRVTALQLEVT 61
Query: 56 KDGSVATAVAEVMKNAGK--IDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMT 113
D S+ T V++V + G +++L+NNAG + + + + + N V+ +T
Sbjct: 62 CDKSMDTFVSKVEEIVGSDGLNLLVNNAGNAVDYPCKAKPNRALFAEQLNVNTTSVVILT 121
Query: 114 QAVLPHMREQXXXXXXXXXXXXXXVPVAFGA------------------IYSASKHALEA 155
Q ++P + + V + Y SK A+
Sbjct: 122 QKLMPLLIKASSKVSGDQLSASRAAVVTISSGLASMTDFATGGHAPNAFAYRISKAAINM 181
Query: 156 YTEALDHEVRNQGIRVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEK 210
+ AL +++++ I V+ I P +KT D+ ++ L ++ L S K
Sbjct: 182 FGRALANDMKDDHILVASIGPGWVKT-----DMGGEKALLTVEQSTAELVASFNK 231
>7293189 [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 598
Score = 48.9 bits (115), Expect = 7e-06
Identities = 54/230 (23%), Positives = 102/230 (43%), Gaps = 24/230 (10%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVEL---DVTKDGSVA 61
+V ++TGA +G+G + A G +V G S + ++ ++ K G A
Sbjct: 13 RVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEA 72
Query: 62 TA-----------VAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVM 110
A + +K G++D+L+NNAG+ + + ++S + + D +L G
Sbjct: 73 VADYNSVIDGAKVIETAIKAFGRVDILVNNAGI-LRDRSLVKTSEQDWNLVNDVHLKGSF 131
Query: 111 RMTQAVLPHMREQXXXXXXXXXXXXXXVPVAFGAI-YSASKHALEAYTEALDHEVRNQGI 169
+ TQA P+M++Q + FG + Y+A+K L L + V +G
Sbjct: 132 KCTQAAFPYMKKQ-NYGRIIMTSSNSGIYGNFGQVNYTAAKMGL----IGLANTVAIEGA 186
Query: 170 RVSVIDPHLIKTPMFSKDLEPDRPLSIYSETRKRLATSMEKQL--ESAEE 217
R +V+ ++ T S+ E P +++E + +L + L ES E+
Sbjct: 187 RNNVLCNVIVPTAA-SRMTEGILPDILFNELKPKLIAPVVAYLCHESCED 235
>Hs4503301 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 335
Score = 48.5 bits (114), Expect = 1e-05
Identities = 51/196 (26%), Positives = 78/196 (39%), Gaps = 11/196 (5%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRK---------GAQPNTNYSFKMVELDVT 55
KV ITG +G+G + L G + SRK T ++ DV
Sbjct: 60 KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119
Query: 56 KDGSVATAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
V V+E++K AG +++INNA G + E S K I D L G +T
Sbjct: 120 DPDMVQNTVSELIKVAGHPNIVINNAA-GNFISPTERLSPNAWKTITDIVLNGTAFVTLE 178
Query: 116 VLPHM-REQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVI 174
+ + + Q F +++K +EA +++L E G+R +VI
Sbjct: 179 IGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVI 238
Query: 175 DPHLIKTPMFSKDLEP 190
P IKT L+P
Sbjct: 239 QPGPIKTKGAFSRLDP 254
>At4g05530 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 254
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/186 (24%), Positives = 78/186 (41%), Gaps = 13/186 (6%)
Query: 5 KVVLITGASSGIGLDIAEKLQLDGYEVFGTSRKGAQPNTNYSFKMVELDVTKDGSVA--- 61
KV ++T ++ GIG I E+ L+G V +SRK A + + K+ + G V
Sbjct: 12 KVAIVTASTQGIGFGITERFGLEGASVVVSSRKQANVDEAVA-KLKSKGIDAYGIVCHVS 70
Query: 62 ------TAVAEVMKNAGKIDVLINNAGVGISWAAAEESSIEQSKFIFDTNLFGVMRMTQA 115
V + ++ GKID+++ NA S S +++ N+ + + Q
Sbjct: 71 NAQHRRNLVEKTVQKYGKIDIVVCNAAANPSTDPILSSKEAVLDKLWEINVKSSILLLQD 130
Query: 116 VLPHMREQXXXXXXXXXXXXXXVPVAFGAIYSASKHALEAYTEALDHEVRNQGIRVSVID 175
+ PH+ + P A+Y +K AL T+AL E+ RV+ +
Sbjct: 131 MAPHLEKGSSVIFITSIAGFS--PQGAMAMYGVTKTALLGLTKALAAEMA-PDTRVNAVA 187
Query: 176 PHLIKT 181
P + T
Sbjct: 188 PGFVPT 193
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.132 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,335,366
Number of Sequences: 60738
Number of extensions: 484720
Number of successful extensions: 2164
Number of sequences better than 1.0e-05: 174
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 168
Number of HSP's that attempted gapping in prelim test: 1836
Number of HSP's gapped (non-prelim): 186
length of query: 268
length of database: 30,389,216
effective HSP length: 105
effective length of query: 163
effective length of database: 24,011,726
effective search space: 3913911338
effective search space used: 3913911338
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)