ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV0264 check: MH T KOG1450 Signal transduction mechanisms Predicted Rho GTPase-activating protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV0264 92292 98294 2001
(2001 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YER155c [T] KOG1450 Predicted Rho GTPase-activating protein 1616 0.0
Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein 110 3e-23
Hs11038641 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 104 1e-21
Hs11038639 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 104 2e-21
Hs14210510 [T] KOG1450 Predicted Rho GTPase-activating protein 101 1e-20
Hs20977541 [R] KOG4407 Predicted Rho GTPase-activating protein 99 7e-20
Hs11641401 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 99 9e-20
Hs10835201 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 96 8e-19
CE06642 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 96 8e-19
CE06641 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 96 8e-19
CE26357 [R] KOG4407 Predicted Rho GTPase-activating protein 93 5e-18
Hs5902012_2 [T] KOG1453 Chimaerin and related Rho GTPase activat... 92 6e-18
7289304 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 92 1e-17
7295587 [R] KOG4407 Predicted Rho GTPase-activating protein 91 1e-17
Hs4502813 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 90 4e-17
Hs13775230 [T] KOG4270 GTPase-activator protein 90 4e-17
CE00918 [T] KOG1450 Predicted Rho GTPase-activating protein 87 3e-16
7290597 [T] KOG1453 Chimaerin and related Rho GTPase activating ... 87 4e-16
Hs20536040 [T] KOG4270 GTPase-activator protein 84 3e-15
SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein 82 9e-15
Hs5803145 [T] KOG4370 Ral-GTPase effector RLIP76 81 1e-14
Hs4757980 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 80 4e-14
Hs22050706 [T] KOG4271 Rho-GTPase activating protein 79 7e-14
Hs16163690 [Z] KOG3565 Cdc42-interacting protein CIP4 77 4e-13
Hs4758750_2 [T] KOG1453 Chimaerin and related Rho GTPase activat... 77 4e-13
YPL115c [T] KOG4269 Rac GTPase-activating protein BCR/ABR 75 1e-12
CE16059 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr 75 1e-12
7302107 [T] KOG1452 Predicted Rho GTPase-activating protein 74 2e-12
Hs7661882 [T] KOG4270 GTPase-activator protein 72 9e-12
7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr 72 1e-11
SPAC26A3.09 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 71 2e-11
7294614 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 70 3e-11
CE03768 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 70 3e-11
7293122 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activa... 70 4e-11
Hs4758882 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 67 4e-10
Hs21361736 [T] KOG4270 GTPase-activator protein 65 8e-10
CE20680 [Z] KOG3565 Cdc42-interacting protein CIP4 65 8e-10
Hs22040999 [Z] KOG3565 Cdc42-interacting protein CIP4 65 1e-09
CE28644 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activa... 65 1e-09
YBR260c [T] KOG1450 Predicted Rho GTPase-activating protein 64 2e-09
Hs7662208 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-acti... 64 2e-09
SPBC28E12.03_2 [T] KOG1453 Chimaerin and related Rho GTPase acti... 64 2e-09
Hs13491176 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 64 2e-09
Hs7656904 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 64 3e-09
Hs22045949 [T] KOG1449 Predicted Rho GTPase-activating protein C... 64 3e-09
Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 64 3e-09
HsM19923515 [T] KOG4270 GTPase-activator protein 63 5e-09
Hs21264597 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 63 5e-09
Hs16975484 [TZ] KOG1117 Rho- and Arf-GTPase activating protein A... 63 5e-09
Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4 63 5e-09
Hs7662242 [T] KOG4270 GTPase-activator protein 62 7e-09
Hs4502221 [T] KOG4271 Rho-GTPase activating protein 62 7e-09
SPAC29A4.11_2 [T] KOG1453 Chimaerin and related Rho GTPase activ... 62 1e-08
Hs16445031 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 61 2e-08
7293370 [T] KOG4271 Rho-GTPase activating protein 61 2e-08
Hs7706107 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 61 2e-08
Hs5174427 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 60 3e-08
Hs22065906 [T] KOG4724 Predicted Rho GTPase-activating protein 60 3e-08
CE23779_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 60 5e-08
Hs4757766 [TZ] KOG4406 CDC42 Rho GTPase-activating protein 59 6e-08
Hs4505507 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-acti... 59 6e-08
Hs7706137_1 [T] KOG4270 GTPase-activator protein 59 1e-07
HsM7019433 [R] KOG3564 GTPase-activating protein 58 1e-07
Hs21361397 [R] KOG3564 GTPase-activating protein 58 1e-07
Hs21314774 [T] KOG4724 Predicted Rho GTPase-activating protein 58 1e-07
Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 58 1e-07
Hs20270373 [T] KOG4724 Predicted Rho GTPase-activating protein 58 1e-07
YDR379w_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 58 1e-07
CE21517 [T] KOG4270 GTPase-activator protein 58 2e-07
7300563 [T] KOG4270 GTPase-activator protein 58 2e-07
Hs14765644 [T] KOG1453 Chimaerin and related Rho GTPase activati... 55 1e-06
YOR127w_2 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 55 1e-06
CE02727_2 [T] KOG1452 Predicted Rho GTPase-activating protein 54 2e-06
Hs7661982 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 53 6e-06
CE27576 [TZ] KOG2710 Rho GTPase-activating protein 53 6e-06
CE11336 [TZ] KOG2710 Rho GTPase-activating protein 53 6e-06
CE09612 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3 52 1e-05
>YER155c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 2167
Score = 1616 bits (4184), Expect = 0.0
Identities = 931/2139 (43%), Positives = 1270/2139 (58%), Gaps = 202/2139 (9%)
Query: 13 NEDKHKGS-----GHSIGTSSNSAPSSHRGSTTSTNSGLSISRHGSLPKSASNLYXXXXX 67
N DK K S TSS+ S T+T S SI+ +L + ++
Sbjct: 76 NRDKRKSSVFPPSKQYTSTSSSQVNLGMYHSDTNTRSSRSIA--STLKDDSPSVCSEDEI 133
Query: 68 XXXXXXXXXXXXXHDLQTVTDEESIDSI-PGHSNSLTPVISSNKDSMTINGGSGSTYAIN 126
+ S DS+ P S+SL+P S T+ S +T I+
Sbjct: 134 SNSSSQKSNAQDETPIAYKKSAHSKDSLLPSRSSSLSPPQSRCSTGTTLEK-SLNTSGIS 192
Query: 127 NLTYDNKHASSVSNNDQSNADIRSESLDRSHTPALQLNSDNFDSMVFKTGWMNKSHG--- 183
N SS +NN+ SN + +E R+ + LNS+N+D+ VFKTGW+NKSHG
Sbjct: 193 N--------SSGTNNNNSNNNNDNEQKQRN---VIHLNSENYDTTVFKTGWVNKSHGQTV 241
Query: 184 --------TVHTPXXXXXXXXXRN-----HRESRIYGXXXXXXXXXXXXXXXXQ------ 224
T + RN +RESR YG
Sbjct: 242 ATNYNSSMTAPSSSSSSSSQNLRNDAYSRNRESRFYGNDGSSLKNDDSSSTTATNSGNDV 301
Query: 225 ----------------EYRLYKAQLKGCVLNLYKSGI-SNAKFLDPTLDPPDTKHEHEED 267
+YRLY+AQLKGCVLNLYKSG+ SN KF DPTL ++ +E
Sbjct: 302 ASARSSMAIDPQMLVPDYRLYRAQLKGCVLNLYKSGLNSNIKFFDPTLPASNSSIANENH 361
Query: 268 PQLPTPPLMTDIPVSTSKEQNSSKEAGPISSPSSKQSTVSAIQTKDNETNVSKDIT-EIK 326
Q K+Q ++ Q+ A+ K + + + IT ++K
Sbjct: 362 QQ--------------KKQQTNN------------QAQAEALHQKQSFGQMGEPITLDLK 395
Query: 327 YLSEIYPHPNLKIDKHDQIVFGTVESICHAVLF-------------SVTLETKKIVDLIL 373
YLSE+YPHP+L+ D +I+ GT+ES+CH VLF S++ + +++L+L
Sbjct: 396 YLSEVYPHPDLRQDSDGKIISGTIESLCHTVLFYPGPKQSDVPNEKSLSKTHRAVINLLL 455
Query: 374 MLPLIEDFSLFFQCFCLYGKTFSKNSEKLTNDSKQFHKVSPATDELMTQRLALVVKTVLD 433
M PL++ F F + F +G +F+KN +LTN+S QF+ +SPA D+ MTQRLAL KT+LD
Sbjct: 456 MFPLLDHFIKFLKVFNQFGLSFTKNKSRLTNNSTQFYNISPAVDDSMTQRLALTAKTILD 515
Query: 434 VFPGFLLDDTTFNHIINLLDIISLHDDEISNSLKLAIAESHNKLNKLVSFSKK----PVD 489
VFPGFLLD+ II+LLD ISLH+DEISN+LK+ IA HN+L KL +F++
Sbjct: 516 VFPGFLLDEPMLKTIISLLDTISLHNDEISNNLKIKIANKHNELMKLTAFTRSLPMATSS 575
Query: 490 QNAISKFVDVKEFLKLDNAILADQIHAINLTYNKIWSPQKDYSLLYDSAF-NKNYIDLNP 548
+ + +D FL LD LAD++H INL ++K+W+P+ DYSLLYDS F N+ + LNP
Sbjct: 576 THELEIILDPSHFLSLDITTLADEVHHINLKFDKVWAPKFDYSLLYDSKFINRRIVSLNP 635
Query: 549 LVFNNRSNIHYVSRLLIEHLFKQID--GTPLHPKERALVLTKWVQLGCTFEKIGDMVSWL 606
LVFNN NIH++ RLLI HLF + PK RA +L KWVQ+GC FE +GDMVSWL
Sbjct: 636 LVFNNDQNIHFLGRLLISHLFPTNPEFSKKVTPKVRAELLDKWVQIGCRFEHLGDMVSWL 695
Query: 607 AIATIICSTPILRLSLTWQYISDQTLKIIFKDWVPTIVQLERRQLSFRTTNSVFILAPPN 666
A+ATIICS P+LR S +W+Y+ DQ+LK IFKDWVPTI+QLERRQ + ++T+SVFILAPPN
Sbjct: 696 AVATIICSIPVLRSS-SWKYVPDQSLKTIFKDWVPTIIQLERRQRTSKSTSSVFILAPPN 754
Query: 667 LNEKSIRENVIPYFGDLTIHTNDLTQDTMFRYLEKKIYRTKNAFQKWQQRLPPIEMANIQ 726
L++ R NVI YFGDL IH +DL DT F+YLEKKI RTKNAF KWQQRL I+ +
Sbjct: 755 LDDDFTRANVISYFGDLLIHADDLPSDTKFKYLEKKINRTKNAFHKWQQRLQAIDSTRHK 814
Query: 727 STP-------QNPDVDFHHYLNYHVSRSRLNVENIMEMSXXXXXXXXXXXXAFANLSKRS 779
+ +P+ + +H+S+ LN+E IM++S S+RS
Sbjct: 815 TNSTENVRDNDSPNNVVYQLWKFHLSQPPLNIEGIMKLSVQHEPPIIDQKAYSTIGSQRS 874
Query: 780 SLLNGSYLPILFNQLFLDYSLFSQTALIGAAGAQNNRQSFVQTNTLSRSGKTLSVSGPLG 839
+L+ GSYLPILFN+LF +YSLF + L+GAA + + +R K+LS+S P+
Sbjct: 875 ALVTGSYLPILFNELFPNYSLFPKNTLVGAA----SDAKLPPPRSSARLSKSLSISEPIP 930
Query: 840 I----------------SPEDKSLITGIDRIDEPVVRELSTKQSNKQMLLKSIRDVFSIN 883
I S D + +TG+ +ID PV++E+S+KQSNKQ LLKS+RDVF+I+
Sbjct: 931 IASNSHTMGSLTDDAMSSKNDNNKVTGVGKIDGPVIKEMSSKQSNKQRLLKSVRDVFNID 990
Query: 884 MDLFHVLDDLTFKSVDDWDKKSRPASVVIETPKRFSVQSS-------------RDSQEVI 930
MD+FH+ D+L FKSV D D KSRPAS+VIETPKRFS SS RDS +
Sbjct: 991 MDVFHISDELVFKSVYDNDGKSRPASMVIETPKRFSQHSSMLINNPATPNQKMRDSLDTT 1050
Query: 931 NRLSVGVENMDFFKNISKTTDSWDEAVINVVLKSASLEKLFDVLVLTSSVFSKLVSINDI 990
RLS +ENMDFF NI + +DS E++I VVLKS+SLEK+FD+LVLTS++FSKLV D+
Sbjct: 1051 GRLSKTLENMDFFNNIGQVSDSLKESIIRVVLKSSSLEKIFDLLVLTSNIFSKLVDTKDL 1110
Query: 991 SAFF-----KNHQGKYNEGNGAGLLDYAIVKLCMDNDLXXXXXXXXXXXXXXXASLLENL 1045
++ + H + + GLLDYA VKL MDND+ ++LEN+
Sbjct: 1111 ENYYYHQRQRGHSTRGLSDDNIGLLDYAFVKLTMDNDIFTETFFNTYKSFTTTTTVLENM 1170
Query: 1046 AKRFIGAKSCAVSIERLV--KDDSRKKATD-----LSGTTNNKFLCWDSASSEFGKEHYL 1098
AKR++GAKSC+VSI +++ DDS+ K + S + F WD ++ + +
Sbjct: 1171 AKRYVGAKSCSVSISKILDRSDDSKMKINEDTNLVSSSLYDQNFPVWDMKVTDDENINLI 1230
Query: 1099 HAAKIQIGTAEALFYLINEHYSDFNDDMHNNKLLLDIIKIMDQEIIDEWDLRITALSDSV 1158
+ AKIQIG AEA+ +L+ HYSDF DD+ NN LLDIIKIM+QE+ EW RI + +
Sbjct: 1231 YMAKIQIGAAEAILHLVKNHYSDFTDDLCNNSTLLDIIKIMEQEVSTEWPTRIA--NSKL 1288
Query: 1159 EKSEAEKSLVIDLNSYHDKLKELLQKIKSSYQRQLYRPVGVSRHNRNTMKILNSFNTITM 1218
+KS E + VI+ + L +L IKS+YQ+QLYRP+GV+R + ILNSFNT +
Sbjct: 1289 QKSLPE-NFVIETENLLTTLTDLFHGIKSAYQKQLYRPIGVNRTQKRITDILNSFNTFSF 1347
Query: 1219 EELNKFALDNSLDDPMVSSFQKLKTDSYGEILNWMYQLDDLILSHLKLATVKEWMVVSQL 1278
+LN D S D M+ SFQKL + +Y +IL W+YQLD+ I L + K+W+V+ Q
Sbjct: 1348 TDLNNIIDDPSFSDDMIRSFQKLHSTNYEDILEWIYQLDNFISKKFNLVSKKDWIVLFQE 1407
Query: 1279 LEGFSYESLSSLFKYSQLDHSYSQITSGNAHPDDLEIVNVFTWLASLV----NGREESLF 1334
LE S ESL S F Y S I G + EI N+FTW+++L+ NG E F
Sbjct: 1408 LELLSKESLVSFFNYPLHFKSSKLINPGYLQLHEFEISNLFTWISTLILKDDNGTESLFF 1467
Query: 1335 KKLPYSIQLITNLHISLTNFFVVQIAQLEKTYESRLETCCIILQMLGFSRYKNSSIDLFQ 1394
+KLP SI+L+ LH SLT FFV++I+ + K+ RL TC +ILQ+L + R+KN S+DLF
Sbjct: 1468 EKLPQSIKLLIKLHTSLTTFFVMEISNVNKSSSERLTTCKVILQILNYIRWKNGSLDLFD 1527
Query: 1395 ATTD-SGSTISPHLPSFIESALINSILSPESRKFEISWKNASEKLGN----TTSLKSVYN 1449
+ D S I PH+P+FIE+A+ ++I+SPESR +E+SW ASEKL + T +L+S+ N
Sbjct: 1528 SEEDESPHAICPHIPAFIETAIAHAIISPESRNYELSWIKASEKLSDPTKGTQNLRSISN 1587
Query: 1450 ILDCV-DASIKKFIEFDGIAPRH-KNFCPCPGWFIGRLLEISQLVPNMSIENSKLINFDK 1507
+L+ + D IK+FIE D + ++ KN CPCPGWFI RLLEISQ VPNMSI NSKLINFDK
Sbjct: 1588 VLEKIDDIHIKRFIEIDDVFSKNCKNLCPCPGWFISRLLEISQFVPNMSITNSKLINFDK 1647
Query: 1508 RRFTFNLVLNYQQLLQTN-----DVDLNIQSP----TFGLIL-NHYEIDPNHSFRNRAKD 1557
RRF N++ N L+ D++++ ++P TFG IL N++E D N +R + K
Sbjct: 1648 RRFVNNIISNVLDLIPNEREFPLDIEMSDENPSKRTTFGRILFNNFE-DVNKVYRKKTKK 1706
Query: 1558 VATSETKLMKYQLRGIFNEVLIAEMYKIKREQKKREHLISQEKELKRSQSLQQVMKQK-- 1615
V+ SE ++Q +G+FNE+L+ E+ KIKRE +K E L+ QEK LK S +L Q + +K
Sbjct: 1707 VSESEAISERFQEQGVFNEILVNEIEKIKREARKLEVLLDQEKILKNSAALHQAVPKKNR 1766
Query: 1616 ----------------SIDMQNSVLAQVXXXXXXXXXXXXXXXXXXXXXXXXXXYTATNS 1659
+I+ + + +S
Sbjct: 1767 KSVIISGTHSDNDHSYNINKNTGQTPSLGSVMESNNSARNRRDSRASFSTNRSSVVSNSS 1826
Query: 1660 GNGVGRKIGGFFKRPXXXXXXXXXXXXXXXXXMLVNSIQQNGAVAPIDLPKISKEELQEQ 1719
NGV +KIGGFF+RP +L + N ++ P LP++ +L +
Sbjct: 1827 HNGVSKKIGGFFRRPFSIGGFNTSSSNYSLNSILSQEVSSNKSILPSILPEVDSMQLHDL 1886
Query: 1720 KPVLSIKTFDIKKCINVNNFSSDASMIYCFKILMENGNEHLIQTIDSHDLSQWLKTIALS 1779
KP S+KTF+IK + + N + + Y FKI+M+NG+E+LIQT S DL++W+K I S
Sbjct: 1887 KPSYSLKTFEIKSIMEIINHRNIPAYYYAFKIVMQNGHEYLIQTASSSDLTEWIKMIKAS 1946
Query: 1780 KRYSFHSKKYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPG 1839
KR+SFHSKKYKGKT NK+FGVP+ED+CERE TL PTIV KLLEEIELRGLDEVGLYR+PG
Sbjct: 1947 KRFSFHSKKYKGKTHNKIFGVPLEDVCERENTLIPTIVVKLLEEIELRGLDEVGLYRIPG 2006
Query: 1840 SVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFI 1899
S+GSIN LKNAFD+EGA N FTLEDDRWFE+N IAGCFK+YLRELP+SLF++ + DF
Sbjct: 2007 SIGSINALKNAFDEEGATDNSFTLEDDRWFEVNAIAGCFKMYLRELPDSLFSHAMVNDFT 2066
Query: 1900 QLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLA 1959
L +++ + E + ++ + L+ LP Y +KRI HL++VH H+ N+MDASNLA
Sbjct: 2067 DLAIKYKAHAMVNEEYKRMMNELLQKLPTCYYQTLKRIVFHLNKVHQHVVNNKMDASNLA 2126
Query: 1960 IVFSMSFINQDDLANSMXXXXXXXXXXXXKFIRYPDTYF 1998
IVFSMSFINQ+DLANSM FI+ P+ YF
Sbjct: 2127 IVFSMSFINQEDLANSMGSRLGAVQTILQDFIKNPNDYF 2165
>Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 316
Score = 110 bits (274), Expect = 3e-23
Identities = 66/212 (31%), Positives = 113/212 (53%), Gaps = 12/212 (5%)
Query: 1761 IQTIDSHDLSQWLKTIA--LSKRYSFHSKKYKGKTSNKVFGVPIEDICEREGTLTPTIVH 1818
+ +IDS + + K + L++R + + + KG ++VFG + ++C+RE P V
Sbjct: 85 VSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVK 144
Query: 1819 KLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCF 1878
+E +E GLD G+YRV G++ I L+ A + + L D +W +I+ I G
Sbjct: 145 LCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHD----EKLDLNDSKWEDIHVITGAL 200
Query: 1879 KLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIF 1938
K++ RELPE LFT DF+ ++Q ++ A +L+RQ LP N ++ +F
Sbjct: 201 KMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVA--AVKDLIRQ----LPKPNQDTMQILF 254
Query: 1939 QHLHRVHNHMDTNRMDASNLAIVFSMSFINQD 1970
+HL RV + + NRM ++AIVF + + +
Sbjct: 255 RHLRRVIENGEKNRMTYQSIAIVFGPTLLKPE 286
>Hs11038641 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1227
Score = 104 bits (260), Expect = 1e-21
Identities = 78/228 (34%), Positives = 111/228 (48%), Gaps = 23/228 (10%)
Query: 1755 NGNEHLIQTIDSHDLSQWLKTIA--------LSKRYS---FHSKKYKGKTSNKVFGVPIE 1803
N NE Q + D W +T+ LS +++ F K+ + VFGV I
Sbjct: 957 NWNELDPQALQDRD---WQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKIA 1013
Query: 1804 DICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTL 1863
+ +RE + P IV + +EEIE RG++EVG+YRV G I LK AFD +V
Sbjct: 1014 VVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMS 1073
Query: 1864 EDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKL 1923
E D +N IAG KLY RELPE LFT+E P+F + + +D + +E+ + L
Sbjct: 1074 EMD----VNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIA--LSDPVAKES---CMLNLL 1124
Query: 1924 RTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQDD 1971
+LP N + HL RV N+M NLA VF + + +
Sbjct: 1125 LSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1172
>Hs11038639 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1271
Score = 104 bits (259), Expect = 2e-21
Identities = 69/188 (36%), Positives = 96/188 (50%), Gaps = 9/188 (4%)
Query: 1784 FHSKKYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGS 1843
F K+ + VFGV I + +RE + P IV + +EEIE RG++EVG+YRV G
Sbjct: 1038 FSLKRMPSRKQTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATD 1097
Query: 1844 INLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVE 1903
I LK AFD +V E D +N IAG KLY RELPE LFT+E P+F + +
Sbjct: 1098 IQALKAAFDVNNKDVSVMMSEMD----VNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIA 1153
Query: 1904 QFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFS 1963
+D + +E+ + L +LP N + HL RV N+M NLA VF
Sbjct: 1154 --LSDPVAKES---CMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFG 1208
Query: 1964 MSFINQDD 1971
+ + +
Sbjct: 1209 PTLLRPSE 1216
>Hs14210510 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 750
Score = 101 bits (252), Expect = 1e-20
Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 19/199 (9%)
Query: 1778 LSKRYSFHSKKYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRV 1837
++KR S + +G ++VFG +E +C+REG P+ + + ++ RGLD G+YRV
Sbjct: 520 IAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRV 579
Query: 1838 PGSVGSINLLKNAFDDEGAVHN----VF----------TLEDDRWFEINTIAGCFKLYLR 1883
G++ + L+ D E AV + VF L+ W +I+ + G KL+LR
Sbjct: 580 SGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLR 639
Query: 1884 ELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHR 1943
ELP+ L LP F + +++Q + +++ + ++P N+ ++ + +HL R
Sbjct: 640 ELPQPLVPPLLLPHFRAALALSESEQCLSQ-----IQELIGSMPKPNHDTLRYLLEHLCR 694
Query: 1944 VHNHMDTNRMDASNLAIVF 1962
V H D NRM NL IVF
Sbjct: 695 VIAHSDKNRMTPHNLGIVF 713
>Hs20977541 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 1957
Score = 99.0 bits (245), Expect = 7e-20
Identities = 71/239 (29%), Positives = 116/239 (47%), Gaps = 20/239 (8%)
Query: 1768 DLSQWLKTIALSKRYSFHSKKYKGKTSNKVFGVPIEDICEREGT--LTPTIVHKLLEEIE 1825
D W K I R +F K T+ FGV ++D C T P IV + +E
Sbjct: 1118 DKGTWRKGIPSIMRKTFEKKP----TATGTFGVRLDD-CPPAHTNRYIPLIVDICCKLVE 1172
Query: 1826 LRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLREL 1885
RGL+ G+YRVPG+ +I+ ++ + A ++ +DD+W ++N I+ K + R+L
Sbjct: 1173 ERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDI---QDDKWRDLNVISSLLKSFFRKL 1229
Query: 1886 PESLFTNEKLPDFIQLVEQFQTDQITEEAFDEL--VRQKLRTLPIYNYHMIKRIFQHLHR 1943
PE LFTN+K DFI+ + E+ D L +++ + LP ++Y +K + HL
Sbjct: 1230 PEPLFTNDKYADFIEANRK-------EDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKT 1282
Query: 1944 VHNHMDTNRMDASNLAIVFSMSFI-NQDDLANSMXXXXXXXXXXXXKFIRYPDTYFVYE 2001
V + + N+M+ NLAIVF + + +D M I++ D +F E
Sbjct: 1283 VAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEE 1341
>Hs11641401 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 859
Score = 98.6 bits (244), Expect = 9e-20
Identities = 64/186 (34%), Positives = 94/186 (50%), Gaps = 9/186 (4%)
Query: 1787 KKYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINL 1846
K+ K VFGV I + +RE + P IV + +EE+E RG++EVG+YR+ G I
Sbjct: 634 KRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQA 693
Query: 1847 LKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQ 1906
LK FD ++ + D +IN IAG KLY RELPE L T+ P F++ +
Sbjct: 694 LKAVFDANN--KDILLMLSD--MDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA--L 747
Query: 1907 TDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSF 1966
+D +E + LR+LP N + +HL RV N+M NLA VF +
Sbjct: 748 SDPAAKE---NCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTL 804
Query: 1967 INQDDL 1972
+ ++
Sbjct: 805 LRPSEV 810
>Hs10835201 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 822
Score = 95.5 bits (236), Expect = 8e-19
Identities = 63/186 (33%), Positives = 93/186 (49%), Gaps = 9/186 (4%)
Query: 1787 KKYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINL 1846
K+ K VFGV I + +RE P IV + +EE+E RG++EVG+YR+ G I
Sbjct: 597 KRTPSKKQTGVFGVKISVVTKREVQGAPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQA 656
Query: 1847 LKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQ 1906
LK FD ++ + D +IN IAG KLY RELPE L T+ P F++ +
Sbjct: 657 LKAVFDANN--KDILLMLSD--MDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA--L 710
Query: 1907 TDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSF 1966
+D +E + +R+LP N + +HL RV N+M NLA VF +
Sbjct: 711 SDPAAKE---NCMMHLVRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTL 767
Query: 1967 INQDDL 1972
+ ++
Sbjct: 768 LRPSEV 773
>CE06642 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 634
Score = 95.5 bits (236), Expect = 8e-19
Identities = 63/180 (35%), Positives = 93/180 (51%), Gaps = 18/180 (10%)
Query: 1797 VFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAF----- 1851
+FGVP++ + E + P I+ K +++++ RGL G+YR G I + NAF
Sbjct: 176 IFGVPLKGLLEHQNRHIPLIIEKSIDQLQRRGLRAKGIYRTCGVKSKIEEICNAFERSSS 235
Query: 1852 DDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQIT 1911
DDE + N + +A KLYLR+LPE L T E DF++L + + Q +
Sbjct: 236 DDEVCLDNENPMN---------LASVVKLYLRKLPEPLLTFELYDDFVRLGTECCSAQAS 286
Query: 1912 ----EEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
EE E +RQ R LP++NY +K I HL+RV + N M SNL+ V + S I
Sbjct: 287 GSNCEEERVEQLRQLARKLPVHNYETLKFIMLHLNRVSWFHEVNLMSTSNLSTVIAPSLI 346
>CE06641 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 863
Score = 95.5 bits (236), Expect = 8e-19
Identities = 63/180 (35%), Positives = 93/180 (51%), Gaps = 18/180 (10%)
Query: 1797 VFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAF----- 1851
+FGVP++ + E + P I+ K +++++ RGL G+YR G I + NAF
Sbjct: 405 IFGVPLKGLLEHQNRHIPLIIEKSIDQLQRRGLRAKGIYRTCGVKSKIEEICNAFERSSS 464
Query: 1852 DDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQIT 1911
DDE + N + +A KLYLR+LPE L T E DF++L + + Q +
Sbjct: 465 DDEVCLDNENPM---------NLASVVKLYLRKLPEPLLTFELYDDFVRLGTECCSAQAS 515
Query: 1912 ----EEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
EE E +RQ R LP++NY +K I HL+RV + N M SNL+ V + S I
Sbjct: 516 GSNCEEERVEQLRQLARKLPVHNYETLKFIMLHLNRVSWFHEVNLMSTSNLSTVIAPSLI 575
>CE26357 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 1388
Score = 92.8 bits (229), Expect = 5e-18
Identities = 61/184 (33%), Positives = 94/184 (50%), Gaps = 19/184 (10%)
Query: 1797 VFGVPIEDI----CEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD 1852
V GV I D CE P IV + IE G+D VG+YR+PG+ ++N LK +
Sbjct: 728 VLGVRIADCPTGSCEDH---VPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNALKESLS 784
Query: 1853 DEGA----VHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTD 1908
+ G + V +L D RW ++N ++ K++LR+LPE L T++ P FI +
Sbjct: 785 NRGFDSVDLSKVESL-DPRWRDVNVVSSLLKMFLRKLPEPLLTDKLYPFFID------AN 837
Query: 1909 QI-TEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
+I T +R LR LP +Y ++ + HL + H D N+M+ NLA++F S +
Sbjct: 838 RISTHHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIV 897
Query: 1968 NQDD 1971
D
Sbjct: 898 RPSD 901
>Hs5902012_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1223
Score = 92.4 bits (228), Expect = 6e-18
Identities = 66/194 (34%), Positives = 99/194 (51%), Gaps = 18/194 (9%)
Query: 1786 SKKYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSIN 1845
SKKY + S++ FGV + + + T+ P +V KL+ IE+ GL G+YR GS I
Sbjct: 724 SKKYDPELSSRQFGVELSRLTSEDRTV-PLVVEKLINYIEMHGLYTEGIYRKSGSTNKIK 782
Query: 1846 LLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQ---LV 1902
L+ D + N+ DD + I+ IA FK +LR+LP L T E +F++ L
Sbjct: 783 ELRQGLDTDAESVNL----DD--YNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQ 836
Query: 1903 EQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF 1962
E+ +T + D+L R L TL +R+ HL R+ DTNRM A+ LAIVF
Sbjct: 837 ERKETIRGVYSVIDQLSRTHLNTL--------ERLIFHLVRIALQEDTNRMSANALAIVF 888
Query: 1963 SMSFINQDDLANSM 1976
+ + D + +
Sbjct: 889 APCILRCPDTTDPL 902
>7289304 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 718
Score = 91.7 bits (226), Expect = 1e-17
Identities = 61/183 (33%), Positives = 93/183 (50%), Gaps = 6/183 (3%)
Query: 1789 YKGKTS-NKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLL 1847
++G T +FG + + +RE P I+ + E+E RG+ EVG YRV GS + L
Sbjct: 500 FRGSTKPGALFGAKMSQVLKREKRDIPFIIGACIREVERRGMLEVGCYRVSGSASDLAKL 559
Query: 1848 KNAFD--DEGAVHNVFTLED-DRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQ 1904
K AF+ + A+ + + E R +I+++ G K +LRELPE+LFT++ P F
Sbjct: 560 KKAFESGEYMALMDAYEAEQLLREVDIHSVTGILKTFLRELPEALFTDQLYPRFFDTFSA 619
Query: 1905 FQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSM 1964
F + +EL++ LP N I I HL RVH N+M NLA+VF
Sbjct: 620 FSNNN-ESTRINELLK-VFEELPQANKASITSILDHLIRVHEKETDNKMSLHNLAMVFGP 677
Query: 1965 SFI 1967
+ +
Sbjct: 678 TLL 680
>7295587 [R] KOG4407 Predicted Rho GTPase-activating protein
Length = 2110
Score = 91.3 bits (225), Expect = 1e-17
Identities = 52/170 (30%), Positives = 89/170 (51%), Gaps = 8/170 (4%)
Query: 1799 GVPIEDI-CEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAV 1857
GVP+ + P +V +E +GL VG+YR+PG+ +I+ L + +
Sbjct: 1198 GVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQ 1257
Query: 1858 HNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDE 1917
DDRW ++N ++ KL++R LP++L +FI+ ++F ++I
Sbjct: 1258 FESCA-SDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADKKFGLERIV------ 1310
Query: 1918 LVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
L+R+ + +LP + Y +K + +HL RV + D NRM+ NLAI+F S I
Sbjct: 1311 LLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSII 1360
>Hs4502813 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 459
Score = 89.7 bits (221), Expect = 4e-17
Identities = 58/181 (32%), Positives = 88/181 (48%), Gaps = 8/181 (4%)
Query: 1792 KTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAF 1851
K KV+ + + + T P +V + EIE RGL+ GLYRV G I +K AF
Sbjct: 260 KHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAF 319
Query: 1852 DDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQIT 1911
D +G ++ + + +IN I G KLY R+LP L T + P FI+ + D+
Sbjct: 320 DRDGEKADISV---NMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQL 376
Query: 1912 EEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQDD 1971
E + + L+ LP + ++ + HL RV H N M+A NL IVF + + +
Sbjct: 377 -----ETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPE 431
Query: 1972 L 1972
L
Sbjct: 432 L 432
>Hs13775230 [T] KOG4270 GTPase-activator protein
Length = 655
Score = 89.7 bits (221), Expect = 4e-17
Identities = 56/175 (32%), Positives = 90/175 (51%), Gaps = 13/175 (7%)
Query: 1797 VFGVPIEDICERE----GTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD 1852
+FG +ED E L P +V + ++ I RGL E GL+R+PG + L++AFD
Sbjct: 39 IFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFD 98
Query: 1853 DEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITE 1912
D +++T+A KLYLRELPE + K DF+ + ++ E
Sbjct: 99 CGEKP------SFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEE--E 150
Query: 1913 EAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
EL +Q +++LP+ NY+++K I + L V ++ N+M NLA VF + +
Sbjct: 151 AGVKELAKQ-VKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNIL 204
>CE00918 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 837
Score = 87.0 bits (214), Expect = 3e-16
Identities = 59/192 (30%), Positives = 93/192 (47%), Gaps = 12/192 (6%)
Query: 1781 RYSFHSKKYKG-KTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPG 1839
R + S K KG VFG + IC+ E +L P + + E IE +GL+ G+YRV G
Sbjct: 590 RPTVESLKEKGIYKPEPVFGSTLSAICQHENSLVPKFIRVITEVIESKGLETDGIYRVSG 649
Query: 1840 SVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFI 1899
++ ++ ++ D + + E+D I+ + G KL+ REL + LF ++
Sbjct: 650 NLSAVQKIRCQADQDN--YKALVSEED----IHVLTGALKLFFRELTDPLFPISLHKEYT 703
Query: 1900 QLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLA 1959
+ Q + F+EL L LP N +K + +HL+RV +H NRM NLA
Sbjct: 704 SAM-QMPNATTRFKKFEEL----LSRLPNENRETLKMLLRHLNRVASHSSQNRMQQHNLA 758
Query: 1960 IVFSMSFINQDD 1971
IVF + + D
Sbjct: 759 IVFGPTLFHNGD 770
>7290597 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 494
Score = 86.7 bits (213), Expect = 4e-16
Identities = 57/172 (33%), Positives = 92/172 (53%), Gaps = 9/172 (5%)
Query: 1797 VFGVPIEDICEREGT-LTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEG 1855
VFG + + + E P +V + +EE+E RG+ + G+YRV G I LK A D EG
Sbjct: 301 VFGTDLTTMVQLEPHHQIPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREG 360
Query: 1856 AVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAF 1915
+ + + + +N IAG KLYLR LP L T + P F + +T + E+
Sbjct: 361 EKTD---MSETAYGNVNVIAGTLKLYLRLLPVPLITFQAYPSF---MAAGRTGKQAEQR- 413
Query: 1916 DELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
+L+ + +R LP ++ ++ + +HL RV +H N+M+ NLA VF+ + I
Sbjct: 414 -QLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTLI 464
>Hs20536040 [T] KOG4270 GTPase-activator protein
Length = 364
Score = 83.6 bits (205), Expect = 3e-15
Identities = 59/176 (33%), Positives = 96/176 (54%), Gaps = 15/176 (8%)
Query: 1790 KGKTSNKVFGVPIEDICEREGTLT---PTIVHKLLEEIELRGLDEVGLYRVPGSVGSINL 1846
K T K+FGV ++++ ER+G P +V ++E + GL + GL+RV G+V +
Sbjct: 43 KDFTYQKLFGVSLQEL-ERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQ 101
Query: 1847 LKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQ 1906
L+ F+ V E + ++ + A KL+LRELP+SL T+ P FIQL + +
Sbjct: 102 LRLKFESGVPV------ELGKDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGR 155
Query: 1907 TDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF 1962
D + E + +L+++ LP +Y ++K + Q L +V H NRM+ NLA VF
Sbjct: 156 ND-VQESSLRDLIKE----LPDTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVF 206
>SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 695
Score = 82.0 bits (201), Expect = 9e-15
Identities = 52/179 (29%), Positives = 90/179 (50%), Gaps = 11/179 (6%)
Query: 1793 TSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD 1852
T + +FG ++ I RE + P IV + ++E GL+ G+YRVP S +N+L++ F+
Sbjct: 499 TKSLLFGARLDAIILREHSNIPNIVMQCTSQVENFGLNLQGIYRVPSSSARVNMLRSQFE 558
Query: 1853 DEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQL--VEQFQTDQI 1910
+ + +D +++ +A K++ REL E L + DFI VE
Sbjct: 559 NNPLLQ--LHTPEDYENDVHAVADLLKIFFRELREPLIPDNHQRDFIDAGNVED------ 610
Query: 1911 TEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQ 1969
E + V + + LP NY I+ + HL ++ + D N+M +NLAI++ + I Q
Sbjct: 611 -ESRRRDAVHRAINDLPDANYSTIRHLTIHLAKIKENSDVNKMSTNNLAIIWGPTIIKQ 668
>Hs5803145 [T] KOG4370 Ral-GTPase effector RLIP76
Length = 655
Score = 81.3 bits (199), Expect = 1e-14
Identities = 55/173 (31%), Positives = 94/173 (53%), Gaps = 20/173 (11%)
Query: 1797 VFGVPIEDICER----EGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD 1852
+FG+P+ D ER +G P + + ++ +E G+ G+YRV G ++ LK A+D
Sbjct: 189 IFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYD 248
Query: 1853 DEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLV-EQFQTDQIT 1911
E + + LED +E NT+A K YLR+LPE+L T E +P F + +T+++
Sbjct: 249 REESTN----LED---YEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQ 301
Query: 1912 EEAFDELVRQKLRTLPIYNYHMIKRIFQHL-HRVHNHMDTNRMDASNLAIVFS 1963
E ++ L+ LP NY +I + H+ H + ++T +M+ N++IV S
Sbjct: 302 E------FQRLLKELPECNYLLISWLIVHMDHVIAKELET-KMNIQNISIVLS 347
>Hs4757980 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 468
Score = 79.7 bits (195), Expect = 4e-14
Identities = 55/171 (32%), Positives = 81/171 (47%), Gaps = 8/171 (4%)
Query: 1792 KTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAF 1851
K KV+ + + + T P +V + EIE RGL GLYRV G I +K AF
Sbjct: 269 KRIKKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAF 328
Query: 1852 DDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQIT 1911
D +G ++ + + +IN I G KLY R+LP + T + FI + D+
Sbjct: 329 DRDGEKADI---SANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERL 385
Query: 1912 EEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF 1962
E V + L LP +Y ++ + HL +V + N M+A NL IVF
Sbjct: 386 -----EAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVF 431
>Hs22050706 [T] KOG4271 Rho-GTPase activating protein
Length = 1499
Score = 79.0 bits (193), Expect = 7e-14
Identities = 52/181 (28%), Positives = 88/181 (47%), Gaps = 11/181 (6%)
Query: 1790 KGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKN 1849
K + FGVP+ + E + P + + +E IE GL G+YRV G+ + L+
Sbjct: 1239 KATWESNYFGVPLTTVVTPEKPI-PIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQR 1297
Query: 1850 AFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQ 1909
FD + HN+ E D F +NT+AG K + ELP+ L I LVE + +
Sbjct: 1298 QFDQD---HNLDLAEKD--FTVNTVAGAMKSFFSELPDPLVPYNMQ---IDLVEAHKIND 1349
Query: 1910 ITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQ 1969
++ +++ L+ P N+ + K + HL++V ++ N M + NL+I F + +
Sbjct: 1350 REQKL--HALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRP 1407
Query: 1970 D 1970
D
Sbjct: 1408 D 1408
>Hs16163690 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 1022
Score = 76.6 bits (187), Expect = 4e-13
Identities = 53/154 (34%), Positives = 78/154 (50%), Gaps = 11/154 (7%)
Query: 1810 GTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRW- 1868
G + P IV + I L GL G++RV GS +N +KN+F+ L DD+
Sbjct: 453 GQVIPLIVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNSFE-----RGENPLADDQSN 507
Query: 1869 FEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPI 1928
+IN++AG KLY R L LF E+ D I + + D + E A +R+ L TLP
Sbjct: 508 HDINSVAGVLKLYFRGLENPLFPKERFNDLISCI---RIDNLYERALH--IRKLLLTLPR 562
Query: 1929 YNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF 1962
+++ +F L+ + + D N MD NLAI F
Sbjct: 563 SVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICF 596
>Hs4758750_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 878
Score = 76.6 bits (187), Expect = 4e-13
Identities = 57/176 (32%), Positives = 88/176 (49%), Gaps = 16/176 (9%)
Query: 1798 FGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAV 1857
FGV ++ + + ++ P ++ KLLE +E+ GL GLYR G+ L+ A + A
Sbjct: 554 FGVCVDSLTSDKASV-PIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAA 612
Query: 1858 HNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDE 1917
LE+ F I+ I G K +LRELPE L T + DF++ VE E ++
Sbjct: 613 ---VKLEN---FPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVE-------LPEKQEQ 659
Query: 1918 L--VRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQDD 1971
L + L LP N++ ++R+ HL +V D NRM LAI+F+ + D
Sbjct: 660 LAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPD 715
>YPL115c [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1128
Score = 75.1 bits (183), Expect = 1e-12
Identities = 51/162 (31%), Positives = 88/162 (53%), Gaps = 14/162 (8%)
Query: 1814 PTIVHKLLEEI-ELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAV-----HNVFTLEDDR 1867
P++V++ LE + + RG+ E G++R+ GS I L+ FD E V + +DD
Sbjct: 927 PSVVYRCLEYLYKNRGIQEEGIFRLSGSSTVIKTLQERFDKEYDVDLCRYNESIEAKDDE 986
Query: 1868 -----WFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQI-TEEAFDELVRQ 1921
+ +NT++G KLYLR+LP LF +E+ F ++V++ + + F EL+
Sbjct: 987 ASPSLYIGVNTVSGLLKLYLRKLPHLLFGDEQFLSFKRVVDENHNNPVQISLGFKELIES 1046
Query: 1922 KLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFS 1963
L +P N ++ +F+ L R++ + N+M+ NL IVFS
Sbjct: 1047 GL--VPHANLSLMYALFELLVRINENSKFNKMNLRNLCIVFS 1086
>CE16059 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 718
Score = 75.1 bits (183), Expect = 1e-12
Identities = 54/175 (30%), Positives = 87/175 (48%), Gaps = 9/175 (5%)
Query: 1789 YKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLK 1848
++ + +FG+ + D+ R G P IV K IE +G+ G+YR G +I L+
Sbjct: 228 FRNRRREPIFGLELTDLYMRTGKKVPVIVEKCCASIEDQGI-VTGIYRQCGIQSNIQRLR 286
Query: 1849 NAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTD 1908
FD GA + L + +I +++ K Y R+LP LFT + P I+ E+ D
Sbjct: 287 AKFDS-GAEPD---LHEFGQRDIYSVSSLLKQYFRQLPNPLFTYQAYPKLIEAFEK--ED 340
Query: 1909 QITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFS 1963
++E+ E +R L T+P +Y K + +HL R+ M + NLAIV+S
Sbjct: 341 SLSEKV--ESLRFSLETMPEAHYRTAKFLMEHLTRLCKSKSLTDMTSKNLAIVWS 393
>7302107 [T] KOG1452 Predicted Rho GTPase-activating protein
Length = 1844
Score = 73.9 bits (180), Expect = 2e-12
Identities = 61/192 (31%), Positives = 87/192 (44%), Gaps = 14/192 (7%)
Query: 1776 IALSKRYSFHSKKYKGKTSNKVFGVPIEDICEREG------TLTPTIVHKLLEEIELRGL 1829
+AL KR S + T +FG +E + RE P ++ + +EE+E RGL
Sbjct: 902 LALYKRRGLPSLRAGYPT---LFGADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRGL 958
Query: 1830 DEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESL 1889
D +GLYR+ GS LL+ AF+ L + +IN I G K YLRELPE L
Sbjct: 959 DIIGLYRLCGSATKKRLLREAFERNS---RAVELTPEHVPDINVITGVLKDYLRELPEPL 1015
Query: 1890 FTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMD 1949
FT + + D E +L+ L LP N + + HL V ++ +
Sbjct: 1016 FTRCLFQMTVDALAVCLPDD--PEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSE 1073
Query: 1950 TNRMDASNLAIV 1961
N+M A LA V
Sbjct: 1074 RNKMSAQALATV 1085
>Hs7661882 [T] KOG4270 GTPase-activator protein
Length = 638
Score = 72.0 bits (175), Expect = 9e-12
Identities = 50/156 (32%), Positives = 79/156 (50%), Gaps = 9/156 (5%)
Query: 1812 LTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEI 1871
L P +V K E I G +E G++R+PG + L++AFD F DR ++
Sbjct: 168 LVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFD--AGERPSF----DRDTDV 221
Query: 1872 NTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNY 1931
+T+A KLYLR+LPE + + F+ + D+ +A EL++Q L LP NY
Sbjct: 222 HTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADE--AKAQQELMKQ-LSILPRDNY 278
Query: 1932 HMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
++ I + LH + + N+M NLA V ++ I
Sbjct: 279 SLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLI 314
>7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 1817
Score = 71.6 bits (174), Expect = 1e-11
Identities = 51/185 (27%), Positives = 92/185 (49%), Gaps = 7/185 (3%)
Query: 1788 KYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLL 1847
K G +VF + + G P ++ E IE G+ + G+YR+ G +I L
Sbjct: 412 KQSGIYRERVFNCDLSEHLLNSGQDIPMVLRSCAEFIENYGVID-GIYRLSGITSNIQRL 470
Query: 1848 KNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQT 1907
+ AFD+E V ++ E + +I+ ++ K+Y RELP L T + +F++ + Q +
Sbjct: 471 RRAFDEE-RVPDLGNPEMKQ--DIHAVSSLLKMYFRELPNPLCTYQLYDNFVEAI-QVKA 526
Query: 1908 DQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
D+ E L+++ + LP +Y +K + +HL++V H M NLAIV++ + +
Sbjct: 527 DEADERL--RLMKETVLKLPPPHYRTLKYLAEHLYKVSQHHGRTGMTDKNLAIVWAPNLL 584
Query: 1968 NQDDL 1972
L
Sbjct: 585 RSPAL 589
>SPAC26A3.09 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1275
Score = 71.2 bits (173), Expect = 2e-11
Identities = 52/172 (30%), Positives = 85/172 (49%), Gaps = 13/172 (7%)
Query: 1797 VFGVPIEDICEREGTLT----PTIVHKLLEEIE-LRGLDEVGLYRVPGSVGSINLLKNAF 1851
+FG+P+ + P +V++ +E +E R E G+YR+ GS +I LK F
Sbjct: 1062 IFGLPLNEAVNISTQFNDSGLPIVVYRCIEYLESCRAEKEEGIYRLSGSASTIKHLKEQF 1121
Query: 1852 DDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQIT 1911
+ EG +++ L D F+++ IAG KLYLR LP +L + + +L+ D
Sbjct: 1122 N-EGVDYDL--LSSDEEFDVHVIAGLLKLYLRNLPTNLL-DTSMHKLFELLPNVPND--- 1174
Query: 1912 EEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFS 1963
A EL + LP N+ ++ + HL R+ N+M+ N+ IVFS
Sbjct: 1175 SAALGELC-DVISKLPPENFALLDSLLHHLRRIIAFEKVNKMNIRNVCIVFS 1225
>7294614 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 476
Score = 70.5 bits (171), Expect = 3e-11
Identities = 59/187 (31%), Positives = 97/187 (51%), Gaps = 22/187 (11%)
Query: 1787 KKYKGKTSNKVFGVPIEDICEREGTLT--PTIVHKLLEEIELRG-LDEVGLYRVPGSVGS 1843
+++K T+++ FGVP++ I L P IV K ++ + + G +D G++R G+
Sbjct: 264 QQHKMATTHQ-FGVPLKFIVMNSPCLNSIPPIVRKCVDSLSITGVIDTEGIFRRSGNHSE 322
Query: 1844 INLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPD---FIQ 1900
I LK + V D + ++ IAG K +LR+L E L T E D F+
Sbjct: 323 IMALKERVNRGEDV-------DLKSVNVHVIAGLLKSFLRDLAEPLLTFELYEDVTGFLD 375
Query: 1901 LVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAI 1960
++ ++ +T+ L+R+KL P NY + K I + L RV + D N+M +SNLAI
Sbjct: 376 WPKEERSRNVTQ-----LIREKL---PEENYELFKYIVEFLVRVMDCEDLNKMTSSNLAI 427
Query: 1961 VFSMSFI 1967
VF +F+
Sbjct: 428 VFGPNFL 434
>CE03768 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 444
Score = 70.1 bits (170), Expect = 3e-11
Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 8/167 (4%)
Query: 1798 FGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAV 1857
FGVP+E I G P IV +L+E +E L G++R ++GSI L++ + +
Sbjct: 247 FGVPLEFILSHCGGNIPPIVDQLIEYLEAHALTMEGVFRKSANIGSIKRLQDRINKGEKI 306
Query: 1858 --HNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAF 1915
N +D+ + + K + R L E L TN P L E +T++
Sbjct: 307 DFENDPEYKDNEYVASLHASVLLKTFFRSLGEPLTTNRLYPKLAALSEVSKTEK------ 360
Query: 1916 DELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF 1962
V++ ++ LP NY ++K + + L RV + N M A+NL++VF
Sbjct: 361 SAAVKEFVKLLPRENYILLKTVIKFLTRVAENSKVNLMTANNLSVVF 407
>7293122 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins
Length = 903
Score = 69.7 bits (169), Expect = 4e-11
Identities = 47/154 (30%), Positives = 77/154 (49%), Gaps = 10/154 (6%)
Query: 1817 VHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRW---FEINT 1873
+ + ++ +E+RGL++ G+YR G I+ L ++ +VF DD++ E NT
Sbjct: 349 IRRCIQVLEIRGLEDEGIYRKSGVGTKISKLLALGLNQKESDDVFV--DDKYRDLMESNT 406
Query: 1874 IAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHM 1933
IA K+YLR L E L T + DFI+ +Q +Q E V + + LP N+ M
Sbjct: 407 IASALKMYLRNLNEPLMTYQYHSDFIEAAKQETLNQRVNE-----VHKLVYKLPQPNFQM 461
Query: 1934 IKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
+ + HL V + N+M NL +VF + +
Sbjct: 462 LDMVICHLTDVSRKYEKNKMSVFNLGVVFGPTLL 495
>Hs4758882 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1261
Score = 66.6 bits (161), Expect = 4e-10
Identities = 54/190 (28%), Positives = 80/190 (41%), Gaps = 25/190 (13%)
Query: 1797 VFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGA 1856
+FG + ++E P I+ EIE R L G+YRV G+ I K E
Sbjct: 668 LFGAEFTLVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGN--KIKTEKLCLALENG 725
Query: 1857 VHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFD 1916
+H L D F + I KLYLR+LPE +FI L ++ Q +E
Sbjct: 726 MH----LVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKK 781
Query: 1917 ELVRQK-------------------LRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASN 1957
+ K LR LP N++ + + HL RV +H + N+M++ N
Sbjct: 782 NSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKN 841
Query: 1958 LAIVFSMSFI 1967
L ++F S I
Sbjct: 842 LGVIFGPSLI 851
>Hs21361736 [T] KOG4270 GTPase-activator protein
Length = 803
Score = 65.5 bits (158), Expect = 8e-10
Identities = 53/232 (22%), Positives = 101/232 (42%), Gaps = 15/232 (6%)
Query: 1774 KTIALSKRYSFHSKKYKGKTSNK-VFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEV 1832
K +A+ ++ + ++ K + K FG P+E+ +R G + + + G+ E
Sbjct: 225 KALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEE 284
Query: 1833 GLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTN 1892
GL+R+ + LK A D + + F + + + +AG K YLRELPE L T
Sbjct: 285 GLFRIGAGASKLKKLKAALDCSTSHLDEF------YSDPHAVAGALKSYLRELPEPLMTF 338
Query: 1893 EKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNR 1952
++ Q+ D+ ++ + + + LP N+ + + + L ++ D N+
Sbjct: 339 NLYEEWTQVASVQDQDKKLQDLW-----RTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNK 393
Query: 1953 MDASNLAIVFSMSFI---NQDDLANSMXXXXXXXXXXXXKFIRYPDTYFVYE 2001
M SN+AIV + + + N+ LA I++ D +F E
Sbjct: 394 MTPSNIAIVLAPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEE 445
>CE20680 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 1059
Score = 65.5 bits (158), Expect = 8e-10
Identities = 49/172 (28%), Positives = 82/172 (47%), Gaps = 9/172 (5%)
Query: 1796 KVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEG 1855
K+FG +++ E G P +V + + L GL+RV GS IN + A++
Sbjct: 523 KLFGGSLDEYVEATGEEIPLLVQSAIAYLSRYSLRNQGLFRVSGSQSEINRFREAYE--- 579
Query: 1856 AVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAF 1915
++F DD + N+ AG KLY REL E +F + F Q + +++ TE F
Sbjct: 580 RGEDLFQYLDD-GSDANSAAGVLKLYFRELREPIF---PIFMFEQFCDCAKSESPTE--F 633
Query: 1916 DELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
R+ + LP+ + +++ +F L + D N M+ NLAI F + +
Sbjct: 634 VRRARELVSKLPVSHVLLLRFLFAFLSHLCEFADENMMEPHNLAICFGPTLL 685
>Hs22040999 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 918
Score = 65.1 bits (157), Expect = 1e-09
Identities = 72/288 (25%), Positives = 118/288 (40%), Gaps = 49/288 (17%)
Query: 1707 DLPKISKEELQEQKPVLSIKTFDIKKCINVNN------------FSSDASM--------- 1745
++ K + LQ + +++++ FD+ C +N F S S+
Sbjct: 233 EVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQE 292
Query: 1746 ---IYCFKILMENGNEHLIQTIDS-HDLSQWLKTIALSKRYSFHSKKYKGKTSNKVFGVP 1801
Y K+ +LI + + HDL Q KT+ S+R S + T K
Sbjct: 293 TEQFYFTKMKEYLEGRNLITKLQAKHDLLQ--KTLGESQRTDC-SLARRSSTVRK----- 344
Query: 1802 IEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD-DEGAVHNV 1860
+ P +V + I GL G++RV GS +N +KNAF+ E +
Sbjct: 345 -----QDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAG- 398
Query: 1861 FTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVR 1920
D ++++IAG KLY R L LF + D + V D + E A +R
Sbjct: 399 ----DQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTM---DNLQERALH--IR 449
Query: 1921 QKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFIN 1968
+ L LP +++ +F L+ + + N MD NLAI F S ++
Sbjct: 450 KVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMS 497
>CE28644 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins
Length = 910
Score = 65.1 bits (157), Expect = 1e-09
Identities = 60/249 (24%), Positives = 105/249 (42%), Gaps = 20/249 (8%)
Query: 1722 VLSIKTFDIKKCINVNNFSSDASMIYCFKILMENGNEHL-IQTIDSHDLSQWLKTIALSK 1780
V TF K C S D +CF + +E N+ + +Q + DL +W+ + +K
Sbjct: 328 VAQTATFKFKSCSRRPMDSIDKR--FCFDVCVEEKNDVMTMQALSEKDLCEWIDAMDGAK 385
Query: 1781 RYSFHSKKYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGS 1840
+ S+ + + ++ K ++DI V + ++ +E G+ E G+YR G
Sbjct: 386 QNSYTAGENPSCSTYKQ--TQLDDIGFE-------FVQQCIDILEESGIHEQGVYRNCGV 436
Query: 1841 VGSINLLKNAFDD--EGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDF 1898
+ + D + + L DD W E TI+ K +LR LPE L T E F
Sbjct: 437 TSKVQKMMMLGLDRRKASEKGGLNLRDDEW-ETKTISSAVKTFLRNLPEPLMTFELHNVF 495
Query: 1899 IQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNL 1958
I + + + + LP + M++ + +HL RV + + N M SNL
Sbjct: 496 INAAKMGDATMRIDH-----IHFYVHQLPAQHLRMLEIVVRHLKRVADLSNENLMTVSNL 550
Query: 1959 AIVFSMSFI 1967
+ F + +
Sbjct: 551 GVCFGPTLL 559
>YBR260c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 666
Score = 64.3 bits (155), Expect = 2e-09
Identities = 50/179 (27%), Positives = 85/179 (46%), Gaps = 8/179 (4%)
Query: 1796 KVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD-DE 1854
K FGVP+E + E E + P IV + + I+ GLD+ G+YR +V ++ LK D D
Sbjct: 468 KTFGVPLESLIEFEQDMVPAIVRQCIYVIDKFGLDQEGIYRKSANVLDVSKLKEEIDKDP 527
Query: 1855 GAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEA 1914
+ + + +I + K + LP+S+ + L I++ Q + D T +
Sbjct: 528 ANISMILPSKPHSDSDIYLVGSLLKTFFASLPDSVLP-KALSSEIKVCLQIE-DPTTRKN 585
Query: 1915 FDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF--SMSFINQDD 1971
F + + LP Y ++ + HL RV H NRM+ L I++ +++ N DD
Sbjct: 586 F---MHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLRALCIIWGPTIAPANPDD 641
>Hs7662208 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins
Length = 814
Score = 64.3 bits (155), Expect = 2e-09
Identities = 44/158 (27%), Positives = 71/158 (44%), Gaps = 8/158 (5%)
Query: 1815 TIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTI 1874
+I+ K + +E RG++E GLYR+ G + L + D T W EI TI
Sbjct: 391 SIIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEW-EIKTI 449
Query: 1875 AGCFKLYLRELPESLFTNEKLPDFIQLVE-QFQTDQITEEAFDELVRQKLRTLPIYNYHM 1933
K YLR LP L + FI+ + + Q +++E + + LP N M
Sbjct: 450 TSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSE------IHSLVHRLPEKNRQM 503
Query: 1934 IKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQDD 1971
++ + HL V N+ N M +NL +VF + + +
Sbjct: 504 LQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQE 541
>SPBC28E12.03_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 804
Score = 64.3 bits (155), Expect = 2e-09
Identities = 53/190 (27%), Positives = 88/190 (45%), Gaps = 19/190 (10%)
Query: 1787 KKYKGKTSNK-VFGVPIEDICEREGTL--TPTIVHKLLEEIELRGLDEVGLYRVPGSVGS 1843
++Y+ K S V+ + +D + TL PT++ + IE G+D GLYR G+
Sbjct: 602 RQYQSKKSESPVWALNPDDFDQNRLTLLRVPTLIVSCINFIESYGMDFEGLYRKSGATSQ 661
Query: 1844 INLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVE 1903
+ + +E V D +I+ + FK YLR LP + T ++ FI
Sbjct: 662 MKKIVALLRNEDTVL-------DPSEDISAVTSVFKQYLRNLPNPIITYDQYFPFITAAN 714
Query: 1904 --QFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIV 1961
FQ + D + +++LP + +++ I +HL RV + NRM + NLA+V
Sbjct: 715 CASFQ------DKLDGFI-MVIKSLPPAHAEILQLIIRHLARVAAYSHANRMTSKNLAVV 767
Query: 1962 FSMSFINQDD 1971
FS + I D
Sbjct: 768 FSPTLIRDPD 777
>Hs13491176 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 383
Score = 63.9 bits (154), Expect = 2e-09
Identities = 47/185 (25%), Positives = 86/185 (46%), Gaps = 18/185 (9%)
Query: 1786 SKKYKGKTSNKVFGVPIEDICERE-----GTLTPTIVHKLLEEIELRGLDEVGLYRVPGS 1840
++K KG+ N +FGVP+ + + + G P ++ K E++E GL+ G++R+ G
Sbjct: 28 TEKVKGR-DNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGC 86
Query: 1841 VGSINLLKNAFDDEGAVHNVFTLEDDRWFEI--NTIAGCFKLYLRELPESLFTNEKLPDF 1898
+ + D + F + +W ++ A K + RELP SLF E +P F
Sbjct: 87 TAKVKQYREELDAK------FNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAF 140
Query: 1899 IQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNL 1958
I L+E+ ++ +A +V LP N + + ++V + NRM N+
Sbjct: 141 ISLMERGPHVKVQFQALHLMV----MALPDANRDAAQALMTFFNKVIANESKNRMSLWNI 196
Query: 1959 AIVFS 1963
+ V +
Sbjct: 197 STVMA 201
>Hs7656904 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 464
Score = 63.5 bits (153), Expect = 3e-09
Identities = 46/171 (26%), Positives = 87/171 (49%), Gaps = 13/171 (7%)
Query: 1798 FGVPIEDICER-EGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGA 1856
FGV ++ + ++ +G L P ++ + + +GL GL+R SV ++ ++ ++
Sbjct: 224 FGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKP 283
Query: 1857 VHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFD 1916
V+ D + +I+ A K +LRELP+ L T + + + + ++T
Sbjct: 284 VNF------DDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTG---- 333
Query: 1917 ELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
RQ LR+LP +NY +++ + LH V N+M++SNLA VF ++ I
Sbjct: 334 --CRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLI 382
>Hs22045949 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 1444
Score = 63.5 bits (153), Expect = 3e-09
Identities = 48/189 (25%), Positives = 84/189 (44%), Gaps = 15/189 (7%)
Query: 1787 KKYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINL 1846
+K K K + FG + + E G P ++ E IE G+ + G+YR+ G +I
Sbjct: 8 QKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQR 66
Query: 1847 LKNAFDDEGA---VHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVE 1903
L+ F + V+ L+D I+ + KLY RELP L T E F + V
Sbjct: 67 LRQEFGSDQCPDLTREVY-LQD-----IHCVGSLCKLYFRELPNPLLTYELYEKFTEAVS 120
Query: 1904 QFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFS 1963
EE ++ ++ LP +Y ++ + +HL + + M A NLA+V++
Sbjct: 121 H-----CPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Query: 1964 MSFINQDDL 1972
+ + ++
Sbjct: 176 PNLLRSKEI 184
>Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 618
Score = 63.5 bits (153), Expect = 3e-09
Identities = 56/181 (30%), Positives = 87/181 (47%), Gaps = 15/181 (8%)
Query: 1788 KYKGKTSNKVFGVPIEDICERE-----GTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVG 1842
K K K S +F VP+ + E++ G P I KL+ IE RGL+ GL R+PG+
Sbjct: 268 KIKTKDSG-LFCVPLTALLEQDQRKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAI 326
Query: 1843 SINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLV 1902
I L + + F E + + A KL++RELP+ L + E L F Q V
Sbjct: 327 RIKNLCQELEAK-FYEGTFNWESVKQHD---AASLLKLFIRELPQPLLSVEYLKAF-QAV 381
Query: 1903 EQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF 1962
+ T + +A + LV LP N +K + + L RV ++ + N+M N+A+V
Sbjct: 382 QNLPTKKQQLQALNLLV----ILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVM 437
Query: 1963 S 1963
+
Sbjct: 438 A 438
>HsM19923515 [T] KOG4270 GTPase-activator protein
Length = 726
Score = 62.8 bits (151), Expect = 5e-09
Identities = 52/232 (22%), Positives = 99/232 (42%), Gaps = 15/232 (6%)
Query: 1774 KTIALSKRYSFHSKKYKGKTSNK-VFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEV 1832
K +A+ ++ + ++ K + K FG P+ + +R G + + + G+ E
Sbjct: 148 KALAVLEKTLPEMRAHQDKWAEKPAFGTPLAEHLKRSGREIALPIEACVMLLLETGMKEE 207
Query: 1833 GLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTN 1892
GL+R+ + LK A D + + F + + + +AG K YLRELPE L T
Sbjct: 208 GLFRIGAGASKLKKLKAALDCSTSHLDEF------YSDPHAVAGALKSYLRELPEPLMTF 261
Query: 1893 EKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNR 1952
++ Q+ D+ ++ + + + LP N+ + + + L ++ D N+
Sbjct: 262 NLYEEWTQVASVQDQDKKLQDLW-----RTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNK 316
Query: 1953 MDASNLAIVFSMSFI---NQDDLANSMXXXXXXXXXXXXKFIRYPDTYFVYE 2001
M SN+AIV + + N+ LA I++ D +F E
Sbjct: 317 MTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEE 368
>Hs21264597 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1205
Score = 62.8 bits (151), Expect = 5e-09
Identities = 46/158 (29%), Positives = 76/158 (47%), Gaps = 11/158 (6%)
Query: 1814 PTIVHKLLEEIELRGLDEVGLYRVPGSVGSIN-LLKNAFDDEGAVHNVFTLEDDRWFEIN 1872
P IV++ ++ I GL G+YR G LL++ D +VH L++ ++
Sbjct: 726 PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH----LKEGEQ-HVD 780
Query: 1873 TIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYH 1932
++ K +LR+LP+ LFT + +++ E ++ + LVR LP N
Sbjct: 781 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVR-----LPPVNRA 835
Query: 1933 MIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQD 1970
+K + HL+ V DTN+M+ NLAIVF + D
Sbjct: 836 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 873
>Hs16975484 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1210
Score = 62.8 bits (151), Expect = 5e-09
Identities = 46/158 (29%), Positives = 76/158 (47%), Gaps = 11/158 (6%)
Query: 1814 PTIVHKLLEEIELRGLDEVGLYRVPGSVGSIN-LLKNAFDDEGAVHNVFTLEDDRWFEIN 1872
P IV++ ++ I GL G+YR G LL++ D +VH L++ ++
Sbjct: 731 PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH----LKEGEQ-HVD 785
Query: 1873 TIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYH 1932
++ K +LR+LP+ LFT + +++ E ++ + LVR LP N
Sbjct: 786 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVR-----LPPVNRA 840
Query: 1933 MIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQD 1970
+K + HL+ V DTN+M+ NLAIVF + D
Sbjct: 841 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 878
>Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 946
Score = 62.8 bits (151), Expect = 5e-09
Identities = 48/176 (27%), Positives = 84/176 (47%), Gaps = 13/176 (7%)
Query: 1794 SNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD- 1852
+ ++FG +E + G P +V + I L GL G++RV G+ ++ +++AF+
Sbjct: 501 NQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFER 560
Query: 1853 DEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPD-FIQLVEQFQTDQIT 1911
E + T D ++++AG KLY R L LF PD F +L+ + +
Sbjct: 561 GEDPLVEGCTAHD-----LDSVAGVLKLYFRSLEPPLFP----PDLFGELLASSELEATA 611
Query: 1912 EEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
E E V + L LP +++ +F L+ + + D N MD NLA+ F + +
Sbjct: 612 ERV--EHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLL 665
>Hs7662242 [T] KOG4270 GTPase-activator protein
Length = 818
Score = 62.4 bits (150), Expect = 7e-09
Identities = 53/204 (25%), Positives = 89/204 (42%), Gaps = 14/204 (6%)
Query: 1798 FGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAV 1857
FG P+E+ G + + + G+ E GL+RV S + LK A D V
Sbjct: 253 FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDC--CV 310
Query: 1858 HNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDE 1917
+V D + IAG K YLRELPE L T E ++IQ + D+ + ++
Sbjct: 311 VDVQEYSADP----HAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNA 366
Query: 1918 LVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI---NQDDLAN 1974
+ LP N++ I+ + + L ++ + D N+M SN+AIV + + + ++
Sbjct: 367 CEK-----LPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITE 421
Query: 1975 SMXXXXXXXXXXXXKFIRYPDTYF 1998
M I++ D +F
Sbjct: 422 MMTTVSLQIVGIIEPIIQHADWFF 445
>Hs4502221 [T] KOG4271 Rho-GTPase activating protein
Length = 1499
Score = 62.4 bits (150), Expect = 7e-09
Identities = 48/174 (27%), Positives = 85/174 (48%), Gaps = 13/174 (7%)
Query: 1798 FGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAV 1857
FG+P++D+ E + P V K +E IE GL LYRV G+ ++ F + +
Sbjct: 1257 FGMPLQDLVTAEKPI-PLFVEKCVEFIEDTGLCTERLYRVSGNKTDQENIQKQFVQDHNI 1315
Query: 1858 HNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVE-QFQTDQITEEAFD 1916
N+ ++E +N +AG K + +LP+ L P+ ++ + +T+++ A
Sbjct: 1316 -NLVSME----VTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERL--HALK 1368
Query: 1917 ELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQD 1970
E+V+ + P+ NY + + + HL+RV N M A NL+I F + D
Sbjct: 1369 EIVK---KFHPV-NYDVFRYVITHLNRVSQQHKINLMTADNLSICFGQPLMRPD 1418
>SPAC29A4.11_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 841
Score = 61.6 bits (148), Expect = 1e-08
Identities = 44/186 (23%), Positives = 91/186 (48%), Gaps = 15/186 (8%)
Query: 1794 SNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDD 1853
S +FG +E+ + EG++ P ++ + ++ GL+ G+YR+ GS + +L + F++
Sbjct: 646 SPTMFGRSLENQLKIEGSVLPQVIAMCVSCVDAHGLEVEGIYRISGSASQVRVLVDEFEN 705
Query: 1854 EGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEE 1913
G++ D + K YL LPE + + + ++ E+ + EE
Sbjct: 706 -GSIRMEHLTSD-----LFACTSVLKTYLHRLPEPVIPGTQYEELLE-AEKIE----KEE 754
Query: 1914 AFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSF----INQ 1969
E V + ++TL + + + + HL RV H + N M++ N++ VF+ + +N+
Sbjct: 755 EKIERVVEVMKTLHPAHLSVFRFLIAHLGRVCKHAEKNLMNSKNVSTVFAPTLMRDKVNR 814
Query: 1970 DDLANS 1975
DL ++
Sbjct: 815 FDLQHA 820
>Hs16445031 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 995
Score = 61.2 bits (147), Expect = 2e-08
Identities = 50/180 (27%), Positives = 86/180 (47%), Gaps = 14/180 (7%)
Query: 1789 YKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLK 1848
YK K VFGVP+ +R G P + + L + LD+VGL+R G I+ L+
Sbjct: 537 YKDKA---VFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALR 593
Query: 1849 NAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTD 1908
+E NV ED ++ +A K + R+LPE LFTN+ F+ + +
Sbjct: 594 QM--NENFPENV-NYEDQSAYD---VADMVKQFFRDLPEPLFTNKLSETFLHIYQ----- 642
Query: 1909 QITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFIN 1968
+++E + V+ + L N +++ + L+ V N ++ N+M NLA+ + S +
Sbjct: 643 YVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFH 702
>7293370 [T] KOG4271 Rho-GTPase activating protein
Length = 553
Score = 61.2 bits (147), Expect = 2e-08
Identities = 44/165 (26%), Positives = 80/165 (47%), Gaps = 13/165 (7%)
Query: 1814 PTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINT 1873
P ++K +E IE GLD G+YRVPGS +++L F+++ T D +N
Sbjct: 356 PIFLNKCVEFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEED-----TNTEIDALDIPVNA 410
Query: 1874 IAGCFKLYLRELPESLFTNEKLPDFIQLV-------EQFQTDQITEEAFDEL-VRQKLRT 1925
+A K + + LF+ + + + ++ + + T+ + + ++ L+
Sbjct: 411 VATALKDFFSKRLPPLFSKDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQK 470
Query: 1926 LPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQD 1970
LP N+ ++K IFQH V ++ N MD+ NLAI + + I D
Sbjct: 471 LPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPID 515
>Hs7706107 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 970
Score = 60.8 bits (146), Expect = 2e-08
Identities = 52/182 (28%), Positives = 81/182 (43%), Gaps = 13/182 (7%)
Query: 1797 VFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGA 1856
+FGV + P +V K EIE R LD G+YRV GS + L AF++ A
Sbjct: 548 LFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRA 607
Query: 1857 VHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQI----TE 1912
+ L + +++++ K +L+EL E + FI L + D T
Sbjct: 608 L---VELSGNSPHDVSSV---LKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTP 661
Query: 1913 EAFDELVRQK---LRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQ 1969
+++R L LP NY+ ++ + HL RV N+M A+NL IVF + +
Sbjct: 662 SPSPDVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRP 721
Query: 1970 DD 1971
D
Sbjct: 722 PD 723
>Hs5174427 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 1091
Score = 60.5 bits (145), Expect = 3e-08
Identities = 47/176 (26%), Positives = 82/176 (45%), Gaps = 11/176 (6%)
Query: 1797 VFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGA 1856
VFGVP+ +R G P + + + + LD+VGL++ G I L+ +EGA
Sbjct: 638 VFGVPLTVNVQRTGQPLPQSIQQAMRYLRNHCLDQVGLFKKSGVKSRIQALRQM--NEGA 695
Query: 1857 VHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFD 1916
+ V E +++ A K Y R+LPE L TN+ F+Q+ + DQ
Sbjct: 696 IDCV-NYEGQSAYDV---ADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRL----- 746
Query: 1917 ELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQDDL 1972
+ ++ + LP N +++ + L V + N+M +NLA+ + S + + L
Sbjct: 747 QAIKAAIMLLPDENRVVLQTLLYFLCDVTAAVKENQMTPTNLAVCLAPSLFHLNTL 802
>Hs22065906 [T] KOG4724 Predicted Rho GTPase-activating protein
Length = 975
Score = 60.5 bits (145), Expect = 3e-08
Identities = 45/172 (26%), Positives = 84/172 (48%), Gaps = 14/172 (8%)
Query: 1796 KVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEG 1855
++FG+ + +ICE + P + +L + +G G++R +V S LK +
Sbjct: 145 QLFGISLPNICENDNLPKPVL--DMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGV 202
Query: 1856 AVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAF 1915
VH L+ + F IA K +LR +P S+F+++ ++ ++ DQ +E
Sbjct: 203 EVH----LDCESIF---VIASVLKDFLRNIPGSIFSSDLYDHWVSVM-----DQGNDEEK 250
Query: 1916 DELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
V++ L LP N +++ +F LH + H +N+M A NLA+ + S +
Sbjct: 251 INTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSIL 302
>CE23779_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 837
Score = 59.7 bits (143), Expect = 5e-08
Identities = 47/183 (25%), Positives = 84/183 (45%), Gaps = 16/183 (8%)
Query: 1796 KVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEG 1855
+ FG + I + + T+ PT++ +L IE R L G+YR GS+ + ++ +
Sbjct: 495 RFFGASLVSIVDDDHTV-PTLLDRLFFAIETRALFVEGVYRKSGSLPQVRSIRKVIESTA 553
Query: 1856 AVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAF 1915
+V LED ++ + K + REL E + + +F+ + E E
Sbjct: 554 DADSV-NLED---IGVHVLTTLVKAFFRELAEPIIIFDLYENFLNVSEV--------EDM 601
Query: 1916 DELVR---QKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQDDL 1972
E VR + LP N ++ R+ HL RV + N+M +NLA++F + + D
Sbjct: 602 GERVRCLSVMIELLPKPNRAVLDRLMYHLARVADQEAVNKMGCNNLALIFGPCVLRRQDS 661
Query: 1973 ANS 1975
A++
Sbjct: 662 AHA 664
>Hs4757766 [TZ] KOG4406 CDC42 Rho GTPase-activating protein
Length = 439
Score = 59.3 bits (142), Expect = 6e-08
Identities = 42/181 (23%), Positives = 87/181 (47%), Gaps = 14/181 (7%)
Query: 1795 NKVFGVPIEDICER--EGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD 1852
N+ FGV ++ + E+ E P ++ + + ++ L G++R + + ++ ++
Sbjct: 239 NQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYN 298
Query: 1853 DEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITE 1912
++ D++ E++ A K +LRELPE L T + P + + ++ ++
Sbjct: 299 MG------LPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPA 352
Query: 1913 EAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQDDL 1972
Q L+TLP NY +++ + L ++ H D N+M +NLA+VF + + D
Sbjct: 353 TL------QVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDA 406
Query: 1973 A 1973
A
Sbjct: 407 A 407
>Hs4505507 [T] KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins
Length = 802
Score = 59.3 bits (142), Expect = 6e-08
Identities = 48/161 (29%), Positives = 71/161 (43%), Gaps = 8/161 (4%)
Query: 1817 VHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAG 1876
V K + IE +G+ GLYR GS + L NAF D +V D ++I TI
Sbjct: 390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSD--WDIKTITS 447
Query: 1877 CFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKR 1936
K YLR L E + T + + + D A LV + LP N M++
Sbjct: 448 SLKFYLRNLSEPVMTYRLHKELVSAAKSDNLD-YRLGAIHSLVYK----LPEKNREMLEL 502
Query: 1937 IFQHLHRVHNHMDTNRMDASNLAIVFSMSFIN-QDDLANSM 1976
+ +HL V H N M SN+ ++F + + Q+D +M
Sbjct: 503 LIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAM 543
>Hs7706137_1 [T] KOG4270 GTPase-activator protein
Length = 262
Score = 58.5 bits (140), Expect = 1e-07
Identities = 44/172 (25%), Positives = 86/172 (49%), Gaps = 14/172 (8%)
Query: 1794 SNKVFGVPIEDICE--REGTLTPTIVHKLLEEIELRG-LDEVGLYRVPGSVGSINLLKNA 1850
+NK+FG+P++++ + P IV +++ IE G L++ GL++V G+ ++ L+
Sbjct: 17 ANKIFGIPLDELQQGGHPDIEVPFIVRHVVDYIEEHGGLEQQGLFQVNGNAETVEWLRQR 76
Query: 1851 FDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQI 1910
+D V V + ++ + + +L+ELPE + +QL + +
Sbjct: 77 YDSGEEVDLV------KEADVPSAISLLRFFLQELPEPVIPGSLHIHLMQLSQDYN---- 126
Query: 1911 TEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF 1962
E+ F +R L+ LP NY ++K + + L V +H + A++LA VF
Sbjct: 127 NEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAVF 177
>HsM7019433 [R] KOG3564 GTPase-activating protein
Length = 632
Score = 58.2 bits (139), Expect = 1e-07
Identities = 49/166 (29%), Positives = 72/166 (42%), Gaps = 11/166 (6%)
Query: 1802 IEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVF 1861
+ D + + P+IV + EIE RGL E GLYR+ G ++ LK F V +
Sbjct: 351 LADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLS 410
Query: 1862 TLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQ 1921
++D I+ I K +LR L E L T F++ E D + Q
Sbjct: 411 KVDD-----IHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMY-----Q 460
Query: 1922 KLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
+ LP N + + HL RV T +MD +NLA VF + +
Sbjct: 461 AVGELPQANRDTLAFLMIHLQRVAQSPHT-KMDVANLAKVFGPTIV 505
>Hs21361397 [R] KOG3564 GTPase-activating protein
Length = 632
Score = 58.2 bits (139), Expect = 1e-07
Identities = 49/166 (29%), Positives = 72/166 (42%), Gaps = 11/166 (6%)
Query: 1802 IEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVF 1861
+ D + + P+IV + EIE RGL E GLYR+ G ++ LK F V +
Sbjct: 351 LADFVSQTSPMIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLS 410
Query: 1862 TLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQ 1921
++D I+ I K +LR L E L T F++ E D + Q
Sbjct: 411 KVDD-----IHAICSLLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMY-----Q 460
Query: 1922 KLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFI 1967
+ LP N + + HL RV T +MD +NLA VF + +
Sbjct: 461 AVGELPQANRDTLAFLMIHLQRVAQSPHT-KMDVANLAKVFGPTIV 505
>Hs21314774 [T] KOG4724 Predicted Rho GTPase-activating protein
Length = 731
Score = 58.2 bits (139), Expect = 1e-07
Identities = 52/192 (27%), Positives = 88/192 (45%), Gaps = 26/192 (13%)
Query: 1797 VFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGA 1856
+F P+ IC TL P + +L + L+G G++R + + LK + A
Sbjct: 85 LFDQPLSIICGDSDTL-PRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDA 143
Query: 1857 VHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVE-QFQTDQITEEAF 1915
V D ++ +A FK +LR +P L +++ +++ +E Q + D+I
Sbjct: 144 V-------DLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRI----- 191
Query: 1916 DELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF-----------SM 1964
E ++Q LP N ++K + LH + + + NRMD+SNLAI S+
Sbjct: 192 -EALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQSL 250
Query: 1965 SFINQDDLANSM 1976
SF Q DL N +
Sbjct: 251 SFEAQKDLNNKV 262
>Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 710
Score = 58.2 bits (139), Expect = 1e-07
Identities = 52/193 (26%), Positives = 89/193 (45%), Gaps = 20/193 (10%)
Query: 1786 SKKYKGKTSN-KVFGVPIEDICERE-----GTLTPTIVHKLLEEIELRGLDEVGLYRVPG 1839
SK K K + ++FGVP++ + E + T P ++ LL +E RGLD G+ RVPG
Sbjct: 227 SKAGKWKAAETRLFGVPLDSLLEADHKVLPSTQVPLVLQALLSCLEKRGLDMEGILRVPG 286
Query: 1840 SVGSINLLKNAFDDEGAVHNVFTLEDDRWFEI--NTIAGCFKLYLRELPESLFTNEKLPD 1897
S + L+ + + F W E+ N + K ++R+LP L T E LP
Sbjct: 287 SQARVKGLEQKLERD------FYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPA 340
Query: 1898 FIQLVEQFQTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASN 1957
F + Q +++ + LP N + +K + + L +V N+M N
Sbjct: 341 FAVVPNIPNLKQRL-----QVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRN 395
Query: 1958 LAIVFSMS-FINQ 1969
++ V + + F++Q
Sbjct: 396 VSTVMAPNLFLHQ 408
>Hs20270373 [T] KOG4724 Predicted Rho GTPase-activating protein
Length = 266
Score = 58.2 bits (139), Expect = 1e-07
Identities = 52/192 (27%), Positives = 88/192 (45%), Gaps = 26/192 (13%)
Query: 1797 VFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGA 1856
+F P+ IC TL P + +L + L+G G++R + + LK + A
Sbjct: 85 LFDQPLSIICGDSDTL-PRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDA 143
Query: 1857 VHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVE-QFQTDQITEEAF 1915
V D ++ +A FK +LR +P L +++ +++ +E Q + D+I
Sbjct: 144 V-------DLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRI----- 191
Query: 1916 DELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVF-----------SM 1964
E ++Q LP N ++K + LH + + + NRMD+SNLAI S+
Sbjct: 192 -EALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQSL 250
Query: 1965 SFINQDDLANSM 1976
SF Q DL N +
Sbjct: 251 SFEAQKDLNNKV 262
>YDR379w_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 868
Score = 58.2 bits (139), Expect = 1e-07
Identities = 50/201 (24%), Positives = 88/201 (42%), Gaps = 31/201 (15%)
Query: 1797 VFGVPIEDICEREGTLTPTIVHKLLEEIELR--GLDEVGLYRVPGSVGSINLLKNAFDDE 1854
++G ++ C E + P I+ ++ IE GL+ GLYR GS + ++N F
Sbjct: 644 LYGSSLQARCAYEKSTVPIIIRCCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIENEFAQN 703
Query: 1855 GAVH--------NVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQ 1906
++H N +D I+ +A K YLR+LP+ + + I LV Q
Sbjct: 704 NSLHSDTLSPKLNALLNQD-----IHAVASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQ 758
Query: 1907 T------------DQITEEAFDELVRQKL----RTLPIYNYHMIKRIFQHLHRVHNHMDT 1950
D + E+V + L + LP+ + ++K + H+ +V +
Sbjct: 759 LIERLPLNNDKFLDSPQKVTIYEMVLKSLLEIFKILPVEHQEVLKVLAAHIGKVRRCSER 818
Query: 1951 NRMDASNLAIVFSMSFINQDD 1971
N M+ NL++VF+ S I+ D
Sbjct: 819 NLMNLHNLSLVFAPSLIHDFD 839
>CE21517 [T] KOG4270 GTPase-activator protein
Length = 604
Score = 57.8 bits (138), Expect = 2e-07
Identities = 63/283 (22%), Positives = 118/283 (41%), Gaps = 43/283 (15%)
Query: 1694 VNSIQQNGAVAPIDLPKISKEELQEQKPVLSIKTFDIKKCINVNNFSSDASMIYCFKILM 1753
+N + + +A DL K + QE + +K +K + + F+S S +
Sbjct: 142 LNLVSTDLEIAQKDLEKENSMTHQESLDAIQMKYEGMKDALVTDIFASSVSKEFQL---- 197
Query: 1754 ENGNEHLIQTIDSHDLSQWLKTIALSKRYSFHSKKYKG-------KTSNKVFGVPIEDIC 1806
NEH++ +++ LK K Y + K VFGVP+++
Sbjct: 198 ---NEHMLTSMN-------LKRDYFKKMYEMYEKAIPEVERMIATALPRPVFGVPLDEHL 247
Query: 1807 EREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD------DEGAVHNV 1860
+ ++ K + + G++E G++RV G+ I ++ A D DE +N
Sbjct: 248 SIQKERISGVLTKCCDFLRQNGMNERGIFRVSGNASKIKRIRAALDAGQFDADEKHYNN- 306
Query: 1861 FTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVR 1920
+ + +A K YLRELP+ L + D+++ + + EE F + R
Sbjct: 307 ---------DPHAVASTLKAYLRELPDPLTMDSLQSDWVEAI-----NLEGEERFSAIDR 352
Query: 1921 QKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFS 1963
+ + ++I + + L + + M+ASNLAIVF+
Sbjct: 353 CLKKMTRGHRQNLI-YLMKFLCDLEAKREETSMNASNLAIVFA 394
>7300563 [T] KOG4270 GTPase-activator protein
Length = 740
Score = 57.8 bits (138), Expect = 2e-07
Identities = 46/141 (32%), Positives = 71/141 (49%), Gaps = 11/141 (7%)
Query: 1828 GLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPE 1887
GL+E GL RV + + +K+A + A H L D + + + I KLYLRELPE
Sbjct: 279 GLEEEGLLRVGCASTKLRRMKHALE---AQHVKTPLPLD-YQDPHVIGSILKLYLRELPE 334
Query: 1888 SLFTNEKLPDFIQLVEQF-QTDQITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHN 1946
L T DFI++ E+ + ++ TE ++ L LP NY ++ + + L V
Sbjct: 335 PLLTYNLYKDFIRIAERHSEAERKTE------IKAILTKLPKENYANLRYLTRFLSIVQQ 388
Query: 1947 HMDTNRMDASNLAIVFSMSFI 1967
N+M + NLAIV S + +
Sbjct: 389 RSALNKMSSQNLAIVMSPNML 409
>Hs14765644 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1136
Score = 54.7 bits (130), Expect = 1e-06
Identities = 52/198 (26%), Positives = 80/198 (40%), Gaps = 25/198 (12%)
Query: 1787 KKYKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINL 1846
KK +G+ ++FG P IV K + EIE R L G+YRV G +
Sbjct: 750 KKLQGRL--QLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEK 807
Query: 1847 LKNAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQ 1906
L AF+ N L + + I+ KLYLR+LPE L + + + L +
Sbjct: 808 LCQAFE------NGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSL 861
Query: 1907 TDQITEEAFDE-----------------LVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMD 1949
+ +A +R+ LR LP N ++ + +HL R+
Sbjct: 862 KAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQ 921
Query: 1950 TNRMDASNLAIVFSMSFI 1967
N+M NL IVF + +
Sbjct: 922 DNKMTPGNLGIVFGPTLL 939
>YOR127w_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 884
Score = 54.7 bits (130), Expect = 1e-06
Identities = 46/191 (24%), Positives = 83/191 (43%), Gaps = 18/191 (9%)
Query: 1795 NKVFGVPIEDICEREGTLTPTIVHKLLEEIEL--RGLDEVGLYRVPGSVGSINLLKNAFD 1852
+ ++G + C E P I+ ++ IE + G+YR GS I ++ F
Sbjct: 663 SNLYGSSLVARCNYENNEIPMILSVCIDFIESDEENMRSEGIYRKSGSQLVIEEIEKQFS 722
Query: 1853 DEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQ-------- 1904
N T ++N + G K YLR+LP +FT + ++LV+
Sbjct: 723 AWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIFTFQIYEPLMRLVKSKKMMENLP 782
Query: 1905 FQTDQITEEAFDE--------LVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDAS 1956
F +++ EA + ++ L LP +Y +++ + +H+ +V + NRM
Sbjct: 783 FVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSEHIEKVTRYSHWNRMTLY 842
Query: 1957 NLAIVFSMSFI 1967
NLA+VF+ I
Sbjct: 843 NLALVFAPGLI 853
>CE02727_2 [T] KOG1452 Predicted Rho GTPase-activating protein
Length = 448
Score = 54.3 bits (129), Expect = 2e-06
Identities = 45/174 (25%), Positives = 81/174 (45%), Gaps = 15/174 (8%)
Query: 1795 NKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLK-----N 1849
N VFG+ + + +RE TP ++ +L++EIE RG+D GLY + GSV +L+ N
Sbjct: 188 NGVFGISLSRLVQRERRDTPIVLTRLIQEIEKRGVDYSGLYVLCGSVEKKKMLRAELESN 247
Query: 1850 AFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQ 1909
E A ++ + N IA K +LRELPE L + + ++ +
Sbjct: 248 PLGTELAAESI--------PDTNVIACLIKDFLRELPEPLISPQIHGMLLEAASVALPND 299
Query: 1910 ITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFS 1963
+ + LV + + L + + + + HL V N + + L+++F+
Sbjct: 300 V--QTNRHLVLKIIDCLQLSAKNCLLLVLDHLSTVLCSSPHNGLTPTRLSLIFA 351
>Hs7661982 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 1023
Score = 52.8 bits (125), Expect = 6e-06
Identities = 47/180 (26%), Positives = 83/180 (46%), Gaps = 15/180 (8%)
Query: 1789 YKGKTSNKVFGVPIEDICEREGTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLK 1848
Y+G+ VFGVP +R G P + + + + + LD+VG++R G I L+
Sbjct: 564 YRGQ---HVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQNLR 620
Query: 1849 NAFDDEGAVHNVFTLEDDRWFEINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTD 1908
+E + NV E +++ A K Y R+LPE +FT++ F+Q+ + D
Sbjct: 621 QM--NETSPDNV-CYEGQSAYDV---ADLLKQYFRDLPEPIFTSKLTTTFLQIYQLLPKD 674
Query: 1909 QITEEAFDELVRQKLRTLPIYNYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFIN 1968
Q A + LP N +++ + L + + + N+M A NLA+ + S +
Sbjct: 675 QWLAAA-----QAATLLLPDENREVLQTLLYFLSDIAS-AEENQMTAGNLAVCLAPSIFH 728
>CE27576 [TZ] KOG2710 Rho GTPase-activating protein
Length = 793
Score = 52.8 bits (125), Expect = 6e-06
Identities = 50/172 (29%), Positives = 76/172 (44%), Gaps = 26/172 (15%)
Query: 1814 PTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD--DEGAVHNVFTLEDDRWFEI 1871
P IV + + GL +VGL+RV G+ L+NA + GAV N +E+ ++
Sbjct: 336 PKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVINDNMVENTTSHDV 395
Query: 1872 NTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQI--TEEAFDELVRQKLRTLPIY 1929
T+ K Y R+LP+SL E +I + ++I F LV L TL +
Sbjct: 396 ATL---LKEYFRDLPQSLLPGEHYSAYIGAAKLNVDERIEAIRLLFALLVSPILDTLFV- 451
Query: 1930 NYHMIKRIFQHLHRVHNH-----------MDTNRMDASNLAIVFSMSFINQD 1970
+ + LH V H + N+MDA NLA +F+ S + D
Sbjct: 452 -------LLKFLHEVSCHSQDRHDEDGELLSGNKMDARNLATIFAPSILRVD 496
>CE11336 [TZ] KOG2710 Rho GTPase-activating protein
Length = 553
Score = 52.8 bits (125), Expect = 6e-06
Identities = 50/172 (29%), Positives = 76/172 (44%), Gaps = 26/172 (15%)
Query: 1814 PTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFD--DEGAVHNVFTLEDDRWFEI 1871
P IV + + GL +VGL+RV G+ L+NA + GAV N +E+ ++
Sbjct: 96 PKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVINDNMVENTTSHDV 155
Query: 1872 NTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQI--TEEAFDELVRQKLRTLPIY 1929
T+ K Y R+LP+SL E +I + ++I F LV L TL +
Sbjct: 156 ATL---LKEYFRDLPQSLLPGEHYSAYIGAAKLNVDERIEAIRLLFALLVSPILDTLFV- 211
Query: 1930 NYHMIKRIFQHLHRVHNH-----------MDTNRMDASNLAIVFSMSFINQD 1970
+ + LH V H + N+MDA NLA +F+ S + D
Sbjct: 212 -------LLKFLHEVSCHSQDRHDEDGELLSGNKMDARNLATIFAPSILRVD 256
>CE09612 [TZ] KOG1117 Rho- and Arf-GTPase activating protein ARAP3
Length = 1003
Score = 52.0 bits (123), Expect = 1e-05
Identities = 37/161 (22%), Positives = 63/161 (38%), Gaps = 8/161 (4%)
Query: 1810 GTLTPTIVHKLLEEIELRGLDEVGLYRVPGSVGSINLLKNAFDDEGAVHNVFTLEDDRWF 1869
G P IV K + + G+ G+YR G V + ++ + D+
Sbjct: 582 GDNIPVIVDKCIRFVSAYGMKCEGIYRRNGKVTEAKTILTKLTEDPVGYYPVHENDET-- 639
Query: 1870 EINTIAGCFKLYLRELPESLFTNEKLPDFIQLVEQFQTDQITEEAFDELVRQKLRTLPIY 1929
+ +A + + R+L LF + D L + Q+D++ Q + T +
Sbjct: 640 -VYAVADVLRQFFRKLDAPLFPSSSQADLFDLATESQSDELCAR-----YAQLINTFELV 693
Query: 1930 NYHMIKRIFQHLHRVHNHMDTNRMDASNLAIVFSMSFINQD 1970
+ +K++ HL V H NR NLA VF+ S D
Sbjct: 694 HRSTLKKLIGHLKNVSEHAQENRASVENLAKVFAASLFLTD 734
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 109,828,686
Number of Sequences: 60738
Number of extensions: 4584476
Number of successful extensions: 16839
Number of sequences better than 1.0e-05: 77
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 16627
Number of HSP's gapped (non-prelim): 139
length of query: 2001
length of database: 30,389,216
effective HSP length: 122
effective length of query: 1879
effective length of database: 22,979,180
effective search space: 43177879220
effective search space used: 43177879220
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)