ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV0399 good O KOG1463 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN6/PSMD11
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV0399 138197 139471 425
(425 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDL097c [O] KOG1463 26S proteasome regulatory complex subunit RP... 631 0.0
SPAC23G3.11 [O] KOG1463 26S proteasome regulatory complex subuni... 397 e-110
7303147 [O] KOG1463 26S proteasome regulatory complex subunit RP... 341 1e-93
Hs4506219 [O] KOG1463 26S proteasome regulatory complex subunit ... 335 8e-92
At1g29150 [O] KOG1463 26S proteasome regulatory complex subunit ... 309 4e-84
CE25011 [O] KOG1463 26S proteasome regulatory complex subunit RP... 291 1e-78
CE00232 [O] KOG1463 26S proteasome regulatory complex subunit RP... 208 1e-53
ECU07g0590 [O] KOG1463 26S proteasome regulatory complex subunit... 207 3e-53
Hs4759264 [OT] KOG1464 COP9 signalosome subunit CSN2 105 1e-22
7297479 [OT] KOG1464 COP9 signalosome subunit CSN2 95 2e-19
At2g26990 [OT] KOG1464 COP9 signalosome subunit CSN2 82 2e-15
CE27562 [OT] KOG1464 COP9 signalosome subunit CSN2 70 6e-12
At3g61140 [OT] KOG0686 COP9 signalosome subunit CSN1 54 4e-07
>YDL097c [O] KOG1463 26S proteasome regulatory complex subunit RPN6/PSMD11
Length = 434
Score = 631 bits (1628), Expect = 0.0
Identities = 318/427 (74%), Positives = 365/427 (85%), Gaps = 4/427 (0%)
Query: 3 LEEARNLVGKEDYEKAEAQFLAVLN----HQDAAQPQSISNKDAQEKEQCILELGQLYGT 58
LEEAR LV ++ Y +AE +L++L+ AA S+ +K E+E ILELGQLY T
Sbjct: 8 LEEARRLVNEKQYNEAEQVYLSLLDKDSSQSSAAAGASVDDKRRNEQETSILELGQLYVT 67
Query: 59 THQLKKLAEFVPRSREYMMKVAKSKIAKVLKTLLNDFELIPDSLDTQIEICEDSIDFATK 118
KL EF+P S EYMM+ AKSK KVLKTL+ FE +PDSLD QI +CE SI+FA +
Sbjct: 68 MGAKDKLREFIPHSTEYMMQFAKSKTVKVLKTLIEKFEQVPDSLDDQIFVCEKSIEFAKR 127
Query: 119 EKRIFLKHSLSIRLATLYYQKTHYNESLQLINDLLRQFKKLDDKSSLLEVHLLECKVYHK 178
EKR+FLKHSLSI+LATL+YQK Y +SL LINDLLR+FKKLDDK SL++VHLLE KVYHK
Sbjct: 128 EKRVFLKHSLSIKLATLHYQKKQYKDSLALINDLLREFKKLDDKPSLVDVHLLESKVYHK 187
Query: 179 LRNLTKSKAALTSARTSANSIYCPTLTMAELDLMSGILHCEDKDYKTAFSYFYESFEAFH 238
LRNL KSKA+LT+ART+ANSIYCPT T+AELDLMSGILHCEDKDYKTAFSYF+ESFE++H
Sbjct: 188 LRNLAKSKASLTAARTAANSIYCPTQTVAELDLMSGILHCEDKDYKTAFSYFFESFESYH 247
Query: 239 SQTGSNTFGKACQVLKYMLLSKIMLNLIDEVKTILNAKYTKETYQSRGIDAMKAVAEAYN 298
+ T N++ KACQVLKYMLLSKIMLNLID+VK ILNAKYTKETYQSRGIDAMKAVAEAYN
Sbjct: 248 NLTTHNSYEKACQVLKYMLLSKIMLNLIDDVKNILNAKYTKETYQSRGIDAMKAVAEAYN 307
Query: 299 NRSLLEFNTAMQNYKTELMGDELIRSHFNALYDTLLESNLSKIIEPFECVEVSHISKIIG 358
NRSLL+FNTA++ Y+ ELMGDEL RSHFNALYDTLLESNL KIIEPFECVE+SHISKIIG
Sbjct: 308 NRSLLDFNTALKQYEKELMGDELTRSHFNALYDTLLESNLCKIIEPFECVEISHISKIIG 367
Query: 359 LDAQQVEGKLSQMILDKVFFGVLDQGNGWLYIYETPQQDATYDSSLELINQLNGVVEQLF 418
LD QQVEGKLSQMILDK+F+GVLDQGNGWLY+YETP QDATYDS+LEL+ QLN VV+QLF
Sbjct: 368 LDTQQVEGKLSQMILDKIFYGVLDQGNGWLYVYETPNQDATYDSALELVGQLNKVVDQLF 427
Query: 419 EKAAVLY 425
EKA+VLY
Sbjct: 428 EKASVLY 434
>SPAC23G3.11 [O] KOG1463 26S proteasome regulatory complex subunit RPN6/PSMD11
Length = 421
Score = 397 bits (1019), Expect = e-110
Identities = 208/421 (49%), Positives = 286/421 (67%), Gaps = 9/421 (2%)
Query: 2 SLEEARNLVGKEDYEKAEAQFLAVLNHQDAAQPQSISNKDAQEKEQCILELGQLYGTTHQ 61
SLE A N V D EKA + VLN + S K A E+EQ + L LY ++
Sbjct: 6 SLELANNAVKSNDIEKAIDLYKEVLN-----KGVSKDEKVANEQEQALTNLSDLYVRENR 60
Query: 62 LKKLAEFVPRSREYMMKVAKSKIAKVLKTLLNDFELIPDSLDTQIEICEDSIDFATKEKR 121
LA+ V +SR M +K+K AK+++TL++ F SL QIE+ D I +A KEKR
Sbjct: 61 HNDLAQLVQQSRPLMANFSKAKSAKIVRTLIDKFSGEKKSLPLQIEVANDCIKWAIKEKR 120
Query: 122 IFLKHSLSIRLATLYYQKTHYNESLQLINDLLRQFKKLDDKSSLLEVHLLECKVYHKLRN 181
FL+ +L +L +LYY + Y +++ LIN LL + K++DDK L EVHLLE KVYH +RN
Sbjct: 121 TFLRQALETKLISLYYDNSSYTDAINLINTLLSELKRMDDKMLLTEVHLLESKVYHAIRN 180
Query: 182 LTKSKAALTSARTSANSIYCPTLTMAELDLMSGILHCEDKDYKTAFSYFYESFEAFHSQT 241
+ K++A+LT+A+TSAN++YCP + LDL SGILH +D D+KTA+SYFYE++E F T
Sbjct: 181 IPKARASLTAAKTSANAVYCPPMLQGNLDLQSGILHADDMDFKTAYSYFYEAYEGF---T 237
Query: 242 GSNTFGKACQVLKYMLLSKIMLNLIDEVKTILNAKYTKETYQSRGIDAMKAVAEAYNNRS 301
+ KA LKYMLLS+IMLN + EVK++L K+ Y R I+AM+A+A+A+ NRS
Sbjct: 238 SLDDDKKALSSLKYMLLSQIMLNSVSEVKSLLTGKHAIR-YAGRDIEAMRAIAQAHENRS 296
Query: 302 LLEFNTAMQNYKTELMGDELIRSHFNALYDTLLESNLSKIIEPFECVEVSHISKIIGLDA 361
L +F A+Q+YK EL D +IRSH ++LYD LLE NL +++EPF VEVSHI+++IGL
Sbjct: 297 LADFEKALQDYKPELASDPIIRSHLSSLYDNLLEQNLLRVVEPFSRVEVSHIAELIGLST 356
Query: 362 QQVEGKLSQMILDKVFFGVLDQGNGWLYIYETPQQDATYDSSLELINQLNGVVEQLFEKA 421
QVEGKLSQMILDK+F+G+LDQG+G L +Y+ PQQD TY+++LE+I + VV+ L E
Sbjct: 357 VQVEGKLSQMILDKIFYGILDQGSGCLIVYDEPQQDKTYEAALEVIKNMGTVVDLLIENK 416
Query: 422 A 422
A
Sbjct: 417 A 417
>7303147 [O] KOG1463 26S proteasome regulatory complex subunit RPN6/PSMD11
Length = 422
Score = 341 bits (874), Expect = 1e-93
Identities = 194/430 (45%), Positives = 274/430 (63%), Gaps = 23/430 (5%)
Query: 9 LVGKEDYEKAEAQFLAVLNHQDAAQPQSISNKDAQE-------------KEQCILELGQL 55
+ G +E+A+A L+ +N ++ Q S+ NK ++ KEQ IL+ G+L
Sbjct: 1 MAGATLFERAQA--LSSVNREE--QDSSLLNKLVRDQEGAENDEERIRIKEQGILQQGEL 56
Query: 56 YGTTHQLKKLAEFVPRSREYMMKVAKSKIAKVLKTLLNDFELIPDSLDTQIEICEDSIDF 115
Y + K+LA+ + +R ++ ++K+K AK++++L++ F + ++++C+D I++
Sbjct: 57 YKQEGKAKELADLIKVTRPFLSSISKAKAAKLVRSLVDMFLDMDAGTGIEVQLCKDCIEW 116
Query: 116 ATKEKRIFLKHSLSIRLATLYYQKTHYNESLQLINDLLRQFKKLDDKSSLLEVHLLECKV 175
A +EKR FL+ SL RL LY+ Y E+L L LLR+ KKLDDK+ L+EV LLE K
Sbjct: 117 AKQEKRTFLRQSLEARLIALYFDTALYTEALALGAQLLRELKKLDDKNLLVEVQLLESKT 176
Query: 176 YHKLRNLTKSKAALTSARTSANSIYCPTLTMAELDLMSGILHCED-KDYKTAFSYFYESF 234
YH L NL K++AALTSART+AN+IYCP LDL SGILH D +D+KTAFSYFYE+F
Sbjct: 177 YHALSNLPKARAALTSARTTANAIYCPPKVQGALDLQSGILHAADERDFKTAFSYFYEAF 236
Query: 235 EAFHSQTGSNTFGKACQVLKYMLLSKIMLNLIDEVKTILNAKYTKETYQSRGIDAMKAVA 294
E F S KA LKYMLL KIML D+V +++ K TY R IDAMK+VA
Sbjct: 237 EGFDSVDSV----KALTSLKYMLLCKIMLGQSDDVNQLVSGKLA-ITYSGRDIDAMKSVA 291
Query: 295 EAYNNRSLLEFNTAMQNYKTELMGDELIRSHFNALYDTLLESNLSKIIEPFECVEVSHIS 354
EA + RSL +F A++ YK EL D ++++H LYDT+LE NL +IIEP+ V+V+H++
Sbjct: 292 EASHKRSLADFQAALKEYKKELAEDVIVQAHLGTLYDTMLEQNLCRIIEPYSRVQVAHVA 351
Query: 355 KIIGLDAQQVEGKLSQMILDKVFFGVLDQGNGWLYIYETPQQDATYDSSLELINQLNGVV 414
+ I L QVE KLSQMILDK F G+LDQG G L ++E D TY+ LE I + VV
Sbjct: 352 ESIQLPMPQVEKKLSQMILDKKFSGILDQGEGVLIVFEETPVDKTYERVLETIQSMGKVV 411
Query: 415 EQLFEKAAVL 424
+ L++KA L
Sbjct: 412 DTLYQKAKKL 421
>Hs4506219 [O] KOG1463 26S proteasome regulatory complex subunit RPN6/PSMD11
Length = 422
Score = 335 bits (859), Expect = 8e-92
Identities = 184/398 (46%), Positives = 257/398 (64%), Gaps = 14/398 (3%)
Query: 36 SISNKDAQE--------KEQCILELGQLYGTTHQLKKLAEFVPRSREYMMKVAKSKIAKV 87
SI +D QE KEQ ILELG L T Q +L + R ++ ++K+K A++
Sbjct: 29 SIVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARL 88
Query: 88 LKTLLNDFELIPDSLDTQIEICEDSIDFATKEKRIFLKHSLSIRLATLYYQKTHYNESLQ 147
+++LL+ F + + ++E+C +SI++A EKR FL+ +L RL +LY+ Y E+L
Sbjct: 89 VRSLLDLFLDMEAATGQEVELCLESIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALH 148
Query: 148 LINDLLRQFKKLDDKSSLLEVHLLECKVYHKLRNLTKSKAALTSARTSANSIYCPTLTMA 207
L + LLR+ KK+DDK+ L+EV LLE K YH L NL K++AALTSART+AN+IYCP A
Sbjct: 149 LGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQA 208
Query: 208 ELDLMSGILH-CEDKDYKTAFSYFYESFEAFHSQTGSNTFGKACQVLKYMLLSKIMLNLI 266
LD+ SGI+H E+KD+KTA+SYFYE+FE + S KA LKYMLL KIMLN
Sbjct: 209 TLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSP----KAITSLKYMLLCKIMLNTP 264
Query: 267 DEVKTILNAKYTKETYQSRGIDAMKAVAEAYNNRSLLEFNTAMQNYKTELMGDELIRSHF 326
++V+ +++ K Y R +A+K VA+A NRSL +F A+ +Y+ EL D +I +H
Sbjct: 265 EDVQALVSGKLALR-YAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHL 323
Query: 327 NALYDTLLESNLSKIIEPFECVEVSHISKIIGLDAQQVEGKLSQMILDKVFFGVLDQGNG 386
LYD LLE NL ++IEPF V++ HIS +I L VE KLSQMILDK F G+LDQG G
Sbjct: 324 AKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEG 383
Query: 387 WLYIYETPQQDATYDSSLELINQLNGVVEQLFEKAAVL 424
L I++ P D TY+++LE I ++ VV+ L+ KA L
Sbjct: 384 VLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKL 421
>At1g29150 [O] KOG1463 26S proteasome regulatory complex subunit RPN6/PSMD11
Length = 419
Score = 309 bits (792), Expect = 4e-84
Identities = 165/380 (43%), Positives = 248/380 (64%), Gaps = 9/380 (2%)
Query: 45 KEQCILELGQLYGTTHQLKKLAEFVPRSREYMMKVAKSKIAKVLKTLLNDFELIPDSLDT 104
KEQ I L + + L + + + R + + K+K AK+++ +++ IP + D
Sbjct: 43 KEQAITNLCDRLTEEKRGEDLRKLLTKLRPFFSLIPKAKTAKIVRGIIDAVAKIPGTTDL 102
Query: 105 QIEICEDSIDFATKEKRIFLKHSLSIRLATLYYQKTHYNESLQLINDLLRQFKKLDDKSS 164
QI +C++ +++ EKR FL+ + RLA L + Y E+L L++ L+++ ++LDDK
Sbjct: 103 QITLCKEMVEWTRAEKRTFLRQRVEARLAALLMENKEYVEALALLSTLVKEVRRLDDKLL 162
Query: 165 LLEVHLLECKVYHKLRNLTKSKAALTSARTSANSIYCPTLTMAELDLMSGILHCEDKDYK 224
L+++ LLE K++ LRNL K+KAALT+ART+AN+IY P +DL SGILH E+KDYK
Sbjct: 163 LVDIDLLESKLHFSLRNLPKAKAALTAARTAANAIYVPPAQQGTIDLQSGILHAEEKDYK 222
Query: 225 TAFSYFYESFEAFHSQTGSNTFG--KACQVLKYMLLSKIMLNLIDEVKTILNAKYTKETY 282
T +SYF+E+FE+F N G +A LKYMLL KIM++ D+V I+++K + Y
Sbjct: 223 TGYSYFFEAFESF------NALGDPRAVFSLKYMLLCKIMVSQADDVAGIISSKAGLQ-Y 275
Query: 283 QSRGIDAMKAVAEAYNNRSLLEFNTAMQNYKTELMGDELIRSHFNALYDTLLESNLSKII 342
+DAMKAVA+A++ RSL F A+++YK +L D ++ H ++LYDTLLE NL ++I
Sbjct: 276 VGPDLDAMKAVADAHSKRSLKLFENALRDYKAQLEDDPIVHRHLSSLYDTLLEQNLCRLI 335
Query: 343 EPFECVEVSHISKIIGLDAQQVEGKLSQMILDKVFFGVLDQGNGWLYIYETPQQDATYDS 402
EPF VE++HI+++IGL VE KLSQMILDK F G LDQG G L I+E P+ DA Y +
Sbjct: 336 EPFSRVEIAHIAELIGLPLDHVEKKLSQMILDKKFAGTLDQGAGCLIIFEDPKADAIYSA 395
Query: 403 SLELINQLNGVVEQLFEKAA 422
+LE I + VV+ L+ ++A
Sbjct: 396 TLETIANMGKVVDSLYVRSA 415
>CE25011 [O] KOG1463 26S proteasome regulatory complex subunit RPN6/PSMD11
Length = 438
Score = 291 bits (745), Expect = 1e-78
Identities = 158/384 (41%), Positives = 244/384 (63%), Gaps = 6/384 (1%)
Query: 41 DAQEKEQCILELGQLYGTTHQLKKLAEFVPRSREYMMKVAKSKIAKVLKTLLNDFELIPD 100
D ++KE I+ELG + Q ++L + ++R +++ + K+K AK+++ L++ I D
Sbjct: 56 DIKKKEDSIMELGNILAQNKQTEELRNMIEQTRPFLVSLGKAKAAKLVRDLVDLCLKIDD 115
Query: 101 SL-DTQIEICEDSIDFATKEKRIFLKHSLSIRLATLYYQKTHYNESLQLINDLLRQFKKL 159
D ++ + ++ I +AT++ R FL+ +L+ RL LY Y ++L L DL+R+ KK+
Sbjct: 116 QDGDIKVGLVKECIQWATEQNRTFLRQTLTARLVRLYNDLQRYTQALPLAADLIRELKKV 175
Query: 160 DDKSSLLEVHLLECKVYHKLRNLTKSKAALTSARTSANSIYCPTLTMAELDLMSGILHCE 219
DDK L+EV L E K Y+ L N+ +++A+LT ART+AN+IY A LDL SGILH
Sbjct: 176 DDKDVLVEVELEESKAYYNLSNIGRARASLTGARTTANAIYVNPRMQAALDLQSGILHAA 235
Query: 220 D-KDYKTAFSYFYESFEAFHSQTGSNTFGKACQVLKYMLLSKIMLNLIDEVKTILNAKYT 278
D KD+KTAFSYFYE+FE + S + A LKYMLL K+ML+L DEV ++L+AK
Sbjct: 236 DEKDFKTAFSYFYEAFEGYDSVDEKVS---ALTALKYMLLCKVMLDLPDEVNSLLSAKLA 292
Query: 279 KETYQSRGIDAMKAVAEAYNNRSLLEFNTAMQNYKTELMGDELIRSHFNALYDTLLESNL 338
+ Y +DAMKA+A A RSL +F A ++ EL D ++R HF++L + +LE +L
Sbjct: 293 LK-YNGSDLDAMKAIAAAAQKRSLKDFQVAFGSFPQELQMDPVVRKHFHSLSERMLEKDL 351
Query: 339 SKIIEPFECVEVSHISKIIGLDAQQVEGKLSQMILDKVFFGVLDQGNGWLYIYETPQQDA 398
+IIEP+ V++ H+++ IG+D +VE KLSQMILD+ G LDQG G L ++E D
Sbjct: 352 CRIIEPYSFVQIEHVAQQIGIDRSKVEKKLSQMILDQKLSGSLDQGEGMLIVFEIAVPDE 411
Query: 399 TYDSSLELINQLNGVVEQLFEKAA 422
Y ++L+ I+ + VV+ L+ A+
Sbjct: 412 AYQTALDTIHAMGEVVDALYSNAS 435
>CE00232 [O] KOG1463 26S proteasome regulatory complex subunit RPN6/PSMD11
Length = 456
Score = 208 bits (530), Expect = 1e-53
Identities = 127/392 (32%), Positives = 211/392 (53%), Gaps = 12/392 (3%)
Query: 31 AAQPQSISNKDAQEKEQCILELGQLYGTTHQLKKLAEFVPRSREYMMKVAKSKIAKVLKT 90
+AQ S + + E IL + + + V R + V K++ +K+++
Sbjct: 68 SAQTAKSSEAEVKRCEDLILSYSRQLAKEKDITGIRTLVESIRSFYDLVGKARASKLIRD 127
Query: 91 LLNDFELIPDSLDT--------QIEICEDSIDFATKEKRIFLKHSLSIRLATLYYQKTHY 142
++ I + +I++ + I +AT KR FL+ SL RL LY +
Sbjct: 128 IVEHALTIDQGVGPALDHGKKEKIDLLTNCIGWATSNKREFLRRSLQARLIRLYNDIRDF 187
Query: 143 NESLQLINDLLRQFKKLDDKSSLLEVHLLECKVYHKLRNLTKSKAALTSARTSANSIYCP 202
+ +L DL ++ KKL+D+ L+EV + E K L NL K+K AL +A+T+ NS +
Sbjct: 188 TNAQKLAQDLSKELKKLEDRELLIEVSVEESKSSFNLNNLAKAKTALLTAKTNTNSAFAS 247
Query: 203 TLTMAELDLMSGILH-CEDKDYKTAFSYFYESFEAFHSQTGSNTFGKACQVLKYMLLSKI 261
A +D+ SG+L+ E++DYKT+FSYFYE+FE F S G A LKYM+L KI
Sbjct: 248 PQLQASVDMQSGVLYSAEERDYKTSFSYFYEAFEGFAS-IGDKI--NATSALKYMILCKI 304
Query: 262 MLNLIDEVKTILNAKYTKETYQSRGIDAMKAVAEAYNNRSLLEFNTAMQNYKTELMGDEL 321
MLN +++ +L AK +S I A++++A+A+ RSL +F A+ +K EL+ D++
Sbjct: 305 MLNETEQLAGLLAAKEIVAYQKSPRIIAIRSMADAFRKRSLKDFVKALAEHKIELVEDKV 364
Query: 322 IRSHFNALYDTLLESNLSKIIEPFECVEVSHISKIIGLDAQQVEGKLSQMILDKVFFGVL 381
+ H L +LE +S++IEP+ +E+S+I+++IG+ VE +++MILDK G +
Sbjct: 365 VAVHSQNLERNMLEKEISRVIEPYSEIELSYIARVIGMTVPPVERAIARMILDKKLMGSI 424
Query: 382 DQGNGWLYIYETPQQDATYDSSLELINQLNGV 413
DQ + +Y + SL+ I +L V
Sbjct: 425 DQHGDTVVVYPKADAANQFTRSLKTIRELTKV 456
>ECU07g0590 [O] KOG1463 26S proteasome regulatory complex subunit RPN6/PSMD11
Length = 389
Score = 207 bits (526), Expect = 3e-53
Identities = 118/391 (30%), Positives = 215/391 (54%), Gaps = 19/391 (4%)
Query: 37 ISNKDA--QEKEQCILELGQLYGTTHQLKKLAEFVPRSREYMMKVAKSKIAKVLKTLLND 94
+ +K+A +EKE +LE+ ++ + + + + RE V +I K++++L
Sbjct: 9 LGSKEATLEEKEATVLEIFKILISKGDYCSIGDTITSLREAWEDVTTPRITKIIRSL--- 65
Query: 95 FELIP---DSLDTQIEICEDSIDFATKEKRIFLKHSLSIRLATLYYQKTHYNESLQLIND 151
FE+IP D+ + +++ +++A +E + L+ L + + Y+E+L I
Sbjct: 66 FEMIPYSSDNFEDVLKLLTALVEWADRENKKMLRLELECKRIYALLKTGKYSEALAQIGP 125
Query: 152 LLRQFKKLDDKSSLLEVHLLECKVYHKLRNLTKSKAALTSARTSANSIYCPTLTMAELDL 211
+ + KK DDK +L+ +++ E K ++++++++KSK++LTSAR A S YCP A++DL
Sbjct: 126 VAHELKKYDDKINLITLYVYESKAFYEIKSVSKSKSSLTSARVLAVSAYCPPQLQAQIDL 185
Query: 212 MSGILHCEDKDYKTAFSYFYESFEAFHSQTGSNTFGK----ACQVLKYMLLSKIMLNLID 267
++GI C++++Y A SYF E+ E F T GK AC L+Y++LSKIM N +
Sbjct: 186 LNGIYICDERNYGVASSYFIEALEGF-------TLGKMDVEACVSLRYLILSKIMANRRE 238
Query: 268 EVKTILNAKYTKETYQSRGIDAMKAVAEAYNNRSLLEFNTAMQNYKTELMGDELIRSHFN 327
E+ ++ K T + I + V+E++ NR L ++ + Y ++ D IR H
Sbjct: 239 EIGAVMRNKNTLKHLDDEMIRVLLKVSESFGNRDLKSYSDVLAQYSDQIHQDSFIRDHLQ 298
Query: 328 ALYDTLLESNLSKIIEPFECVEVSHISKIIGLDAQQVEGKLSQMILDKVFFGVLDQGNGW 387
LYD LL+ N+ KIIEP+ V++ I+ ++G D +E KL +MILDK G LD +
Sbjct: 299 YLYDVLLDKNIVKIIEPYSVVKIRFIADVLGFDVNVIEKKLRKMILDKAVDGTLDHIDEC 358
Query: 388 LYIYETPQQDATYDSSLELINQLNGVVEQLF 418
L ++ ++ D ++ + L+ +V +
Sbjct: 359 LILHGEKAKNNFADECMKQVEALDCIVSSRY 389
>Hs4759264 [OT] KOG1464 COP9 signalosome subunit CSN2
Length = 443
Score = 105 bits (263), Expect = 1e-22
Identities = 99/408 (24%), Positives = 186/408 (45%), Gaps = 39/408 (9%)
Query: 35 QSISNKDAQEKEQCILELGQLYGTTHQLKKLAEFVPRSREYMM----KVAKSKIAKVLKT 90
Q + + ++ E L Q+ +L E + R ++ + V ++ K + +
Sbjct: 55 QKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINS 114
Query: 91 LLN------DFELIPDSLDTQIEICEDSIDFATKEKRIFLKHSLSIRLATLYYQKTHYNE 144
+L+ +L+ + +T +E +D+ K R++ K + +L LY ++ Y +
Sbjct: 115 ILDYISTSKQMDLLQEFYETTLEALKDA-----KNDRLWFK--TNTKLGKLYLEREEYGK 167
Query: 145 SLQLINDLLRQFKKLDDK-------SSLLEVHLLECKVYHKLRNLTKSKAALTSARTSAN 197
LQ I L Q + DD + LLE++ LE ++Y +N K KA + +
Sbjct: 168 -LQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKS 226
Query: 198 SIYCPTLTMAELDLMSGILHCEDKDYKTAFSYFYESFEAFHSQTGSNTFGKACQVLKYML 257
+I P L M + G +H + +++ A + F+E+F+ + ++GS + LKY++
Sbjct: 227 AIPHP-LIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNY-DESGSP---RRTTCLKYLV 281
Query: 258 LSKIMLNLIDEVKTILNAKYTKETYQSRG---IDAMKAVAEAYNNRSLLEFNTAMQNYKT 314
L+ +++ K+ +N ++E + I AM + AY N + EF ++ +
Sbjct: 282 LANMLM------KSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHS 335
Query: 315 ELMGDELIRSHFNALYDTLLESNLSKIIEPFECVEVSHISKIIGLDAQQVEGKLSQMILD 374
+M D IR H L + L K+I+P+ + + ISK + +D VE L Q ILD
Sbjct: 336 NIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILD 395
Query: 375 KVFFGVLDQGNGWLYIYETPQQDATYDSSLELINQLNGVVEQLFEKAA 422
G +DQ N L + + A Y + + NQLN + + + K A
Sbjct: 396 NTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA 443
>7297479 [OT] KOG1464 COP9 signalosome subunit CSN2
Length = 444
Score = 94.7 bits (234), Expect = 2e-19
Identities = 78/323 (24%), Positives = 154/323 (47%), Gaps = 22/323 (6%)
Query: 110 EDSIDFATKEKRIFLKHSLSIRLATLYYQKTHYNESLQLINDLLRQFKKLDDK------- 162
E ++D K L + +L LY+ ++ + + LQ I L Q + DD
Sbjct: 134 ETTLDALRDAKNDRLWFKTNTKLGKLYFDRSDFTK-LQKILKQLHQSCQTDDGEDDLKKG 192
Query: 163 SSLLEVHLLECKVYHKLRNLTKSKAALTSARTSANSIYCPTLTMAELDLMSGILHCEDKD 222
+ LLE++ LE ++Y +N K KA + ++I P L M + G +H + +
Sbjct: 193 TQLLEIYALEIQMYTVQKNNKKLKALYEQSLHIKSAIPHP-LIMGVIRECGGKMHLREGE 251
Query: 223 YKTAFSYFYESFEAFHSQTGSNTFGKACQVLKYMLLSKIMLNLIDEVKTILNAKYTKETY 282
++ A + F+E+F+ + ++GS + LKY++L+ +++ K+ +N ++E
Sbjct: 252 FEKAHTDFFEAFKNY-DESGSP---RRTTCLKYLVLANMLM------KSGINPFDSQEAK 301
Query: 283 QSRG---IDAMKAVAEAYNNRSLLEFNTAMQNYKTELMGDELIRSHFNALYDTLLESNLS 339
+ I AM + +Y N + EF T ++ +++ +M D+ IR H L + L
Sbjct: 302 PYKNDPEILAMTNLVNSYQNNDINEFETILRQHRSNIMADQFIREHIEDLLRNIRTQVLI 361
Query: 340 KIIEPFECVEVSHISKIIGLDAQQVEGKLSQMILDKVFFGVLDQGNGWLYIYETPQQDAT 399
K+I P++ + + I+ + ++ +VE L ILD G +DQ N L + + +
Sbjct: 362 KLIRPYKNIAIPFIANALNIEPAEVESLLVSCILDDTIKGRIDQVNQVLQLDKINSSASR 421
Query: 400 YDSSLELINQLNGVVEQLFEKAA 422
Y++ + NQ+ + + +K A
Sbjct: 422 YNALEKWSNQIQSLQFAVVQKMA 444
>At2g26990 [OT] KOG1464 COP9 signalosome subunit CSN2
Length = 433
Score = 82.0 bits (201), Expect = 2e-15
Identities = 72/323 (22%), Positives = 151/323 (46%), Gaps = 21/323 (6%)
Query: 72 SREYMMKVAKSKIAKVLKTLLNDFELIPDSLDTQIEICEDSIDFATKEKRIFLKHSLSIR 131
+R Y K + + V + + L+ + T ++ E++ K +R++ K +L +
Sbjct: 92 TRNYSEKCINNIMDFVSGSASQNTGLLQEFYQTTLKALEEA-----KNERLWFKTNL--K 144
Query: 132 LATLYYQKTHYNESLQLINDLLRQFKKLDDK------SSLLEVHLLECKVYHKLRNLTKS 185
L +++ Y +++ +L + +K D S LLEV+ +E ++Y + ++ K
Sbjct: 145 LCNIWFDIGEYRRMTKILKELHKSCQKEDGTDDQKKGSQLLEVYAIEIQIYTETKDNKKL 204
Query: 186 KAALTSARTSANSIYCPTLTMAELDLMSGILHCEDKDYKTAFSYFYESFEAFHSQTGSNT 245
K A ++I P + M + G +H ++ ++ A + F+E+F+ + + G+
Sbjct: 205 KQLYHKALAIKSAIPHPRI-MGIIRECGGKMHMAERQWEEAATDFFEAFKNY-DEAGNQ- 261
Query: 246 FGKACQVLKYMLLSKIMLNLIDEVKTILNAKYTKETYQSRGIDAMKAVAEAYNNRSLLEF 305
+ Q LKY++L+ +++ EV + + K I AM + AY ++EF
Sbjct: 262 --RRIQCLKYLVLANMLME--SEVNPF-DGQEAKPYKNDPEILAMTNLIAAYQRNEIIEF 316
Query: 306 NTAMQNYKTELMGDELIRSHFNALYDTLLESNLSKIIEPFECVEVSHISKIIGLDAQQVE 365
+++ + +M D IR++ L + L K+I+P+ + + ISK + + V
Sbjct: 317 ERILKSNRRTIMDDPFIRNYMEDLLKKVRTQVLLKLIKPYTKIGIPFISKELNVPETDVT 376
Query: 366 GKLSQMILDKVFFGVLDQGNGWL 388
L +ILD G +D+ N +L
Sbjct: 377 ELLVSLILDSRIDGHIDEMNRYL 399
>CE27562 [OT] KOG1464 COP9 signalosome subunit CSN2
Length = 495
Score = 70.1 bits (170), Expect = 6e-12
Identities = 72/342 (21%), Positives = 154/342 (44%), Gaps = 25/342 (7%)
Query: 60 HQLKKLAEFVPRSREYMMK-VAKSKIAKVLKTLLNDFELIPDSLDTQIEICEDSIDFATK 118
++L+K+ E+ + Y+ V K+ K + +L D+ +D E ++D
Sbjct: 80 NRLEKMLEYYRQLLTYIKSAVTKNYSEKSINAIL-DYISTSRQMDLLQHFYETTLDALKD 138
Query: 119 EKRIFLKHSLSIRLATLYYQKTHYNESLQLINDLLRQFKKLDDK------SSLLEVHLLE 172
K L + +L L++ + + +++ L K + + LLE++ LE
Sbjct: 139 AKNERLWFKTNTKLGKLFFDLHEFTKLEKIVKQLKVSCKNEQGEEDQRKGTQLLEIYALE 198
Query: 173 CKVYHKLRNLTKSK---AALTSARTSANSIYCPTLTMAELDLMSGILHCEDKDYKTAFSY 229
++Y + +N K T A + ++I P L + + G +H D + A +
Sbjct: 199 IQMYTEQKNNKALKWVYELATQAIHTKSAIPHP-LILGTIRECGGKMHLRDGRFLDAHTD 257
Query: 230 FYESFEAFHSQTGSNTFGKACQVLKYMLLSKIMLNLIDEVKTILNAKYTKETYQSRG--- 286
F+E+F+ + ++GS + LKY++L+ ++ +K+ +N ++E +
Sbjct: 258 FFEAFKNY-DESGSP---RRTTCLKYLVLANML------IKSDINPFDSQEAKPFKNEPE 307
Query: 287 IDAMKAVAEAYNNRSLLEFNTAMQNYKTELMGDELIRSHFNALYDTLLESNLSKIIEPFE 346
I AM + +AY + + F M ++ +M D IR H L + + L ++I P+
Sbjct: 308 IVAMTQMVQAYQDNDIQAFEQIMAAHQDSIMADPFIREHTEELMNNIRTQVLLRLIRPYT 367
Query: 347 CVEVSHISKIIGLDAQQVEGKLSQMILDKVFFGVLDQGNGWL 388
V +S++S+ + + ++V L ILD +++ +G +
Sbjct: 368 NVRISYLSQKLKVSQKEVIHLLVDAILDDGLEAKINEESGMI 409
>At3g61140 [OT] KOG0686 COP9 signalosome subunit CSN1
Length = 440
Score = 53.9 bits (128), Expect = 4e-07
Identities = 51/227 (22%), Positives = 96/227 (41%), Gaps = 22/227 (9%)
Query: 207 AELDLMSGILHCEDKDYKTAFSYFYE-------SFEAFHSQTGSNTFGKACQVLKYMLLS 259
A+L SG+ H E K YK A F + S+ + T+G C + +
Sbjct: 215 AKLRCASGLAHLELKKYKLAARKFLDVNPELGNSYNEVIAPQDIATYGGLCALASFDR-- 272
Query: 260 KIMLNLIDEVKTILNAKYTKETYQSRGIDAMKAVAEAYNNR--SLLEFNTAMQNYKTELM 317
E+K ++ + D + + + Y++R S LE+ + + K+ L+
Sbjct: 273 -------SELKAFID-NINFRNFLELVPDVRELINDFYSSRYASCLEY---LASLKSNLL 321
Query: 318 GDELIRSHFNALYDTLLESNLSKIIEPFECVEVSHISKIIGLDAQQVEGKLSQMILDKVF 377
D + H + LYD + + L + PF V++S ++ +E +L +I D
Sbjct: 322 LDIHLHDHVDTLYDQIRKKALIQYTLPFVSVDLSRMADAFKTSVSGLEKELEALITDNQI 381
Query: 378 FGVLDQGNGWLYIYETPQQDATYDSSLELINQLNGVVEQLFEKAAVL 424
+D N LY Q++AT+ L++ N+ + V + +A +L
Sbjct: 382 QARIDSHNKILYARHADQRNATFQKVLQMGNEFDRDVRAMLLRANLL 428
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.133 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,862,769
Number of Sequences: 60738
Number of extensions: 912233
Number of successful extensions: 2954
Number of sequences better than 1.0e-05: 13
Number of HSP's better than 0.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2924
Number of HSP's gapped (non-prelim): 13
length of query: 425
length of database: 30,389,216
effective HSP length: 109
effective length of query: 316
effective length of database: 23,768,774
effective search space: 7510932584
effective search space used: 7510932584
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)