ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV0799 good U KOG3771 Intracellular trafficking, secretion, and vesicular transport Amphiphysin
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV0799 281543 282826 428
(428 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR388w [U] KOG3771 Amphiphysin 551 e-157
SPBC21D10.12 [U] KOG3771 Amphiphysin 349 5e-96
SPBC725.09c [U] KOG3771 Amphiphysin 89 2e-17
YCR009c [U] KOG3771 Amphiphysin 72 2e-12
Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 64 3e-10
YFR024c-a [S] KOG1843 Uncharacterized conserved protein 63 1e-09
YFR024c [S] KOG1843 Uncharacterized conserved protein 63 1e-09
Hs4885611 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 60 6e-09
YHR016c [S] KOG1843 Uncharacterized conserved protein 59 1e-08
7299844 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 59 1e-08
Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin 58 3e-08
Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin 57 4e-08
Hs4757748 [U] KOG3771 Amphiphysin 57 5e-08
CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin 57 5e-08
Hs7706487 [U] KOG3771 Amphiphysin 56 9e-08
Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin 56 1e-07
SPBC12C2.05c [Z] KOG3565 Cdc42-interacting protein CIP4 55 2e-07
Hs21536417 [U] KOG3771 Amphiphysin 55 2e-07
Hs21536415 [U] KOG3771 Amphiphysin 55 2e-07
Hs21536413 [U] KOG3771 Amphiphysin 55 2e-07
Hs21536411 [U] KOG3771 Amphiphysin 55 2e-07
Hs21536409 [U] KOG3771 Amphiphysin 55 2e-07
Hs21536407 [U] KOG3771 Amphiphysin 55 2e-07
SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH... 54 3e-07
Hs4826844 [Z] KOG0162 Myosin class I heavy chain 54 3e-07
Hs22051526 [Z] KOG0162 Myosin class I heavy chain 54 3e-07
CE29545 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 54 4e-07
CE05763 [Z] KOG0162 Myosin class I heavy chain 54 4e-07
SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein 53 1e-06
Hs7662296 [Z] KOG3565 Cdc42-interacting protein CIP4 53 1e-06
7298751 [TU] KOG1029 Endocytic adaptor protein intersectin 52 1e-06
Hs7705296 [U] KOG3771 Amphiphysin 52 2e-06
Hs7661670 [S] KOG1843 Uncharacterized conserved protein 52 2e-06
Hs4505869 [I] KOG1264 Phospholipase C 52 2e-06
CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endop... 51 3e-06
7303429 [U] KOG3771 Amphiphysin 51 3e-06
7294461 [Z] KOG3655 Drebrins and related actin binding proteins 51 4e-06
Hs4885609 [T] KOG0197 Tyrosine kinases 50 5e-06
Hs11321634 [T] KOG4348 Adaptor protein CMS/SETA 50 5e-06
7297777 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 50 5e-06
SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding prot... 50 8e-06
Hs20536136 [T] KOG0192 Tyrosine kinase specific for activated (G... 50 8e-06
>YDR388w [U] KOG3771 Amphiphysin
Length = 482
Score = 551 bits (1420), Expect = e-157
Identities = 290/481 (60%), Positives = 334/481 (69%), Gaps = 54/481 (11%)
Query: 1 MSFKGFTKAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAV 60
MSFKGFTKAV+RAPQSFRQK MG+QT DPVYEDA+RRF+ELE ETKKLS+ESKRY AV
Sbjct: 1 MSFKGFTKAVSRAPQSFRQKFKMGEQTEDPVYEDAERRFQELEQETKKLSEESKRYSTAV 60
Query: 61 NGMLEHQIGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPD 120
NGML HQIGF+K+M EIFKPISGKMSDPNA +PEDNP+GIEASEQY AIV+ELQ TLKPD
Sbjct: 61 NGMLTHQIGFAKSMEEIFKPISGKMSDPNATIPEDNPQGIEASEQYRAIVAELQETLKPD 120
Query: 121 LTLIDEKIVKPAQELLNIINYIRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKK 180
L L++EKIV P QELL II YIRKM+TKRNHKKLDLDR LNTYNK+E+K+ PT KDEE+
Sbjct: 121 LALVEEKIVTPCQELLKIITYIRKMATKRNHKKLDLDRHLNTYNKHEKKKEPTAKDEERL 180
Query: 181 YKAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLNIFYTLYNRFQD 240
YKA+AQV V QQEYDYYND+LKT+LPILF LE+EFVKPLFVSFY+MQLNIFYTLYNR QD
Sbjct: 181 YKAQAQVEVAQQEYDYYNDLLKTQLPILFSLEAEFVKPLFVSFYFMQLNIFYTLYNRLQD 240
Query: 241 MKIPYFDLDTDILEAFQAKRGNIEEQTDALTITHFKLGYSKAKLDLTRRRYG--ATDDXX 298
MKIPYFDL++DI+E++ AK+GN+EEQTDALTITHFKLGYSKAKL++TRR+YG +
Sbjct: 241 MKIPYFDLNSDIVESYIAKKGNVEEQTDALTITHFKLGYSKAKLEMTRRKYGVATAEGSP 300
Query: 299 XXXXXXXXAYGQTY--GQPEQPQQMGYD----------SKLXXXXXXXXYPXXXXXXXXX 346
YG Y P GY
Sbjct: 301 VSGASSGVGYGAGYDPATATSPTPTGYGYGAAAPSYAAQPAAQYGTAAAVGTAAAVGTAA 360
Query: 347 XXXYNSVPTTATQ--ASYTPP-------------------------------------TS 367
+VP T Q A+ +PP +
Sbjct: 361 GAAAGAVPGTYPQYAAAQSPPLTGLGFQQSPQQQQGPPPAYSNPLTSPVAGTPAAAVAAA 420
Query: 368 AGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRS-DAAGWWVGVYNGVQGVFPGNYVELS 426
GVET TALYDY AQA GDL+FPAGA+I++V R+ D WW G YNG QGVFPGNYV+L+
Sbjct: 421 PGVETVTALYDYQAQAAGDLSFPAGAVIEIVQRTPDVNEWWTGRYNGQQGVFPGNYVQLN 480
Query: 427 K 427
K
Sbjct: 481 K 481
>SPBC21D10.12 [U] KOG3771 Amphiphysin
Length = 466
Score = 349 bits (895), Expect = 5e-96
Identities = 191/465 (41%), Positives = 261/465 (56%), Gaps = 40/465 (8%)
Query: 1 MSFKGFTKAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAV 60
MS+KGFTKA+AR PQ+ R K N+G+ T DP+YEDA RRFK LE+E KKL++++K+Y +A+
Sbjct: 1 MSWKGFTKALARTPQTLRSKFNVGEITKDPIYEDAGRRFKSLETEAKKLAEDAKKYTDAI 60
Query: 61 NGMLEHQIGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPD 120
NG+L HQIGF+ A EI+KPISG+ SDP + E N EGIEA+E Y IV +LQ L +
Sbjct: 61 NGLLNHQIGFADACIEIYKPISGRASDPESYEQEGNAEGIEAAEAYKEIVYDLQKNLASE 120
Query: 121 LTLIDEKIVKPAQELLNIINYIRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKK 180
+ +I+ +IV P ELL I+ + K+ KR+HK+LD DR +++ K ++K++ + KDE+K
Sbjct: 121 MDVINTRIVNPTGELLKIVKDVDKLLLKRDHKQLDYDRHRSSFKKLQEKKDKSLKDEKKL 180
Query: 181 YKAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLNIFYTLYNRFQD 240
Y+AE QEY+YYN+MLK ELP LF L F+ PLF FYYMQLN++Y LY +
Sbjct: 181 YEAETAFEQSSQEYEYYNEMLKEELPKLFALAQSFIAPLFQGFYYMQLNVYYVLYEKMSH 240
Query: 241 MKIPYFDLDTDILEAFQAKRGNIEEQTDALTITHFKL--------GYSKAKLDLT----- 287
+I YFD +TDILE+++ +RG+++++ +ALTIT FK G D T
Sbjct: 241 CEIQYFDFNTDILESYERRRGDVKDRAEALTITKFKTAKPTYKRPGMGPGGKDATASSSS 300
Query: 288 ----RRRYGATDDXXXXXXXXXXAY-------GQTYGQPEQPQQMGYDSKLXXXXXXXXY 336
+R A + Y Y P Q + Y
Sbjct: 301 SFSSKREEAAAEPSSSTATDIPPPYSTPSVAGASDYSTPSAGYQTVQTTTTTTEAAAAQY 360
Query: 337 PXXX--------XXXXXXXXXYNSVPTTATQASY-------TPPTSAGVETCTALYDYTA 381
P + P A A+ P + E ALYDY A
Sbjct: 361 PQAAFPPPPVMPQPAAAAVTTPVAAPVAAAAAAVPVPPPAPAPAAAPAAEHVVALYDYAA 420
Query: 382 QAEGDLTFPAGAIIQVVDRSDAAG-WWVGVYNGVQGVFPGNYVEL 425
QA GDL+F AG I+VV R+D WW+G NG QG FPGNYV+L
Sbjct: 421 QAAGDLSFHAGDRIEVVSRTDNQNEWWIGRLNGAQGQFPGNYVQL 465
>SPBC725.09c [U] KOG3771 Amphiphysin
Length = 264
Score = 88.6 bits (218), Expect = 2e-17
Identities = 70/248 (28%), Positives = 108/248 (43%), Gaps = 20/248 (8%)
Query: 1 MSFKGFTKAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAV 60
MS+ GF KAV RA S K ++TVD +E +RR++ +ES KKL E+K Y +A+
Sbjct: 1 MSWHGFKKAVNRAGTSVMMKTGHVERTVDREFETEERRYRTMESAAKKLQKEAKGYLDAL 60
Query: 61 NGMLEHQIGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQA-TLKP 119
M Q + + + K +G+ A Y +V +L A T+K
Sbjct: 61 RAMTASQTRIANTIDAFYGDAGSK-------------DGVSA--YYRQVVEDLDADTVKE 105
Query: 120 DLTLIDEKIVKPAQELLNIINYIRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEK 179
++ P + I TKRNHK LD D K K + D K
Sbjct: 106 LDGPFRTTVLDPISRFCSYFPDINAAITKRNHKLLDHDAMRAKVQKLVDKPS---NDTTK 162
Query: 180 KYKAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLNIFYTLYNRFQ 239
+ E + A+ ++ Y+ N+ L +ELP L L ++ P F + +QL Y +
Sbjct: 163 LPRTEKEAAMAKEVYETLNNQLVSELPQLIALRVPYLDPSFEALVKIQLRFCREGYEKMA 222
Query: 240 DMKIPYFD 247
++ YFD
Sbjct: 223 QVQ-QYFD 229
>YCR009c [U] KOG3771 Amphiphysin
Length = 265
Score = 72.0 bits (175), Expect = 2e-12
Identities = 61/246 (24%), Positives = 110/246 (43%), Gaps = 23/246 (9%)
Query: 1 MSFKGFTKAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAV 60
MS++GF KA+ RA S K N+ +T+D Y+ +RR+K L+ + L E+K + +++
Sbjct: 1 MSWEGFKKAINRAGHSVIIK-NV-DKTIDKEYDMEERRYKVLQRAGEALQKEAKGFLDSL 58
Query: 61 NGMLEHQIGFSKAMSEIF---KPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQA-T 116
+ Q ++ +S ++ K ++G G Y V + + T
Sbjct: 59 RAVTASQTTIAEVISNLYDDSKYVAGG--------------GYNVGNYYLQCVQDFDSET 104
Query: 117 LKPDLTLIDEKIVKPAQELLNIINYIRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKD 176
+K + E ++ P + I + KR+HKK D D + + K KD
Sbjct: 105 VKQLDGPLRETVLDPITKFSTYFKEIEEAIKKRDHKKQDFDAAKAKVRRLVDKP---AKD 161
Query: 177 EEKKYKAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLNIFYTLYN 236
K +AE ++++ + ++ N+ LKTELP L L + P F + +QL Y
Sbjct: 162 ASKLPRAEKELSLAKDIFENLNNQLKTELPQLVSLRVPYFDPSFEALIKIQLRFCTDGYT 221
Query: 237 RFQDMK 242
R ++
Sbjct: 222 RLAQIQ 227
>Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 475
Score = 64.3 bits (155), Expect = 3e-10
Identities = 30/55 (54%), Positives = 39/55 (70%), Gaps = 1/55 (1%)
Query: 370 VETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYVE 424
+E A+YDYT E +L+F GAII V+ ++D GW+ GV NGV G+FPGNYVE
Sbjct: 415 LEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDD-GWYEGVMNGVTGLFPGNYVE 468
>YFR024c-a [S] KOG1843 Uncharacterized conserved protein
Length = 451
Score = 62.8 bits (151), Expect = 1e-09
Identities = 32/77 (41%), Positives = 44/77 (56%), Gaps = 4/77 (5%)
Query: 352 SVPTTATQASYTPPTSAGVET--CTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAG-WWV 408
S P T+ Q +T PTS + ALY + + GDL F G +I ++ +SD+ WW
Sbjct: 375 STPQTS-QGRFTAPTSPSTSSPKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWT 433
Query: 409 GVYNGVQGVFPGNYVEL 425
G NG +G+FP NYVEL
Sbjct: 434 GRVNGREGIFPANYVEL 450
>YFR024c [S] KOG1843 Uncharacterized conserved protein
Length = 373
Score = 62.8 bits (151), Expect = 1e-09
Identities = 32/77 (41%), Positives = 44/77 (56%), Gaps = 4/77 (5%)
Query: 352 SVPTTATQASYTPPTSAGVET--CTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAG-WWV 408
S P T+ Q +T PTS + ALY + + GDL F G +I ++ +SD+ WW
Sbjct: 297 STPQTS-QGRFTAPTSPSTSSPKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWT 355
Query: 409 GVYNGVQGVFPGNYVEL 425
G NG +G+FP NYVEL
Sbjct: 356 GRVNGREGIFPANYVEL 372
>Hs4885611 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 508
Score = 60.1 bits (144), Expect = 6e-09
Identities = 28/55 (50%), Positives = 38/55 (68%), Gaps = 1/55 (1%)
Query: 370 VETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYVE 424
+E A+YDYT + +L+F GAII V+ ++D GW+ GV N V G+FPGNYVE
Sbjct: 448 IEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDD-GWYEGVCNRVTGLFPGNYVE 501
>YHR016c [S] KOG1843 Uncharacterized conserved protein
Length = 468
Score = 59.3 bits (142), Expect = 1e-08
Identities = 25/62 (40%), Positives = 38/62 (60%), Gaps = 1/62 (1%)
Query: 366 TSAGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAG-WWVGVYNGVQGVFPGNYVE 424
T++ T ALY++ + GDL F G +I ++ +SD+ WW G NG +G+FP NYV
Sbjct: 407 TNSATPTAVALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWWTGRTNGKEGIFPANYVR 466
Query: 425 LS 426
+S
Sbjct: 467 VS 468
>7299844 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 473
Score = 59.3 bits (142), Expect = 1e-08
Identities = 25/55 (45%), Positives = 38/55 (68%), Gaps = 1/55 (1%)
Query: 370 VETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYVE 424
+E A+YDY A + +L+F +++ V+ ++D GWW GV +GV G+FPGNYVE
Sbjct: 417 IEKVVAIYDYYADKDDELSFQESSVLYVLKKNDD-GWWEGVMDGVTGLFPGNYVE 470
>Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1221
Score = 57.8 bits (138), Expect = 3e-08
Identities = 32/76 (42%), Positives = 42/76 (55%), Gaps = 4/76 (5%)
Query: 354 PTTATQASYTPPTS---AGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGV 410
P T+ PP S A V +YDYTAQ + +L F G II V+++ D WW G
Sbjct: 1138 PGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKED-PDWWKGE 1196
Query: 411 YNGVQGVFPGNYVELS 426
NG G+FP NYV+L+
Sbjct: 1197 VNGQVGLFPSNYVKLT 1212
>Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 223
Score = 57.4 bits (137), Expect = 4e-08
Identities = 31/76 (40%), Positives = 42/76 (54%), Gaps = 4/76 (5%)
Query: 354 PTTATQASYTPPTS---AGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGV 410
P T+ PP S A V +YDYTAQ + +L F G II ++++ D WW G
Sbjct: 141 PGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINILNKED-PDWWKGE 199
Query: 411 YNGVQGVFPGNYVELS 426
NG G+FP NYV+L+
Sbjct: 200 VNGQVGLFPSNYVKLT 215
>Hs4757748 [U] KOG3771 Amphiphysin
Length = 454
Score = 57.0 bits (136), Expect = 5e-08
Identities = 99/475 (20%), Positives = 161/475 (33%), Gaps = 101/475 (21%)
Query: 8 KAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAVNGMLEHQ 67
K + RA + QKL +T D +E + F + +E +L + + Y +V M E
Sbjct: 20 KKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEAS 79
Query: 68 IGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPDLTLIDEK 127
++ + E+++P + N + E+N DL +D
Sbjct: 80 KKLNECLQEVYEPDWPGRDEANK-IAENN-----------------------DLLWMDYH 115
Query: 128 IVKPAQELLNIINY------IRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKKY 181
Q LL + Y I+ KR K +D D + + YE Q KDE K
Sbjct: 116 QKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYD---SARHHYESLQTAKKKDEAKIA 172
Query: 182 KAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLNIFYTLYNRFQDM 241
KAE ++ Q+ ++ N L+ ELP L+ F F S ++ N + Q++
Sbjct: 173 KAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNL 232
Query: 242 KIPYFDLDTDILEAFQAKRGNIEEQTDALTITHFKLGYSKAKLDLTRRRYGATDDXXXXX 301
D+L +E+Q + T T K+KL RR +D+
Sbjct: 233 --------NDVLV-------GLEKQHGSNTFTVKAQPRKKSKLFSRLRRKKNSDNAPAKG 277
Query: 302 XXXXX--------------------AYGQTYGQ--PEQPQQMGYDSKLXXXXXXXXYPXX 339
A G T G P+ P Q S++
Sbjct: 278 NKSPSPPDGSPAATPEIRVNHEPEPAGGATPGATLPKSPSQPAEASEVAGGTQPAAGAQE 337
Query: 340 XXXXXXXXXXYNSVPTTATQASYTPPTSAGVE----------------TCTALYDYTAQA 383
+S+P + ++ + VE A +DYTA
Sbjct: 338 PGETAASEAASSSLPAVVVE-TFPATVNGTVEGGSGAGRLDLPPGFMFKVQAQHDYTATD 396
Query: 384 EGDLTFPAGAIIQVV----DRSDAAGWWVGVYNG----------VQGVFPGNYVE 424
+L AG ++ V+ GW +GV +GVFP N+ E
Sbjct: 397 TDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTE 451
>CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 57.0 bits (136), Expect = 5e-08
Identities = 33/80 (41%), Positives = 45/80 (56%), Gaps = 6/80 (7%)
Query: 350 YNSVPTTAT-QASYTPPTSAGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWV 408
Y+ VP+ T QAS T P + T +YD+ A DL G I V++++D WW
Sbjct: 878 YDVVPSDVTLQASETAPQQ---QLYTVIYDFEAVETTDLALHVGDTILVLEKNDE--WWK 932
Query: 409 GVYNGVQGVFPGNYVELSKQ 428
G NG +G+FP NYVE+S Q
Sbjct: 933 GRCNGREGIFPANYVEISVQ 952
>Hs7706487 [U] KOG3771 Amphiphysin
Length = 565
Score = 56.2 bits (134), Expect = 9e-08
Identities = 51/206 (24%), Positives = 84/206 (40%), Gaps = 21/206 (10%)
Query: 4 KGFTKAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAVNGM 63
K K +RA + QKL +T D +E + F + ++E KL + K + +AV M
Sbjct: 15 KQVQKKFSRAQEKVLQKLGKAVETKDERFEQSANNFYQQQAEGHKLYKDLKNFLSAVKVM 74
Query: 64 LEHQIGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPDLTL 123
E S+ + EI+ + E+ AIV +
Sbjct: 75 HESSKRVSETLQEIYS------------------SEWDGHEELKAIVWNNDLLWEDYEEK 116
Query: 124 IDEKIVKPAQELLNIINYIRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKKYKA 183
+ ++ V+ + + + I++ KR K +D D + + E QN KDE K KA
Sbjct: 117 LADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYD---SARHHLEAVQNAKKKDEAKTAKA 173
Query: 184 EAQVAVMQQEYDYYNDMLKTELPILF 209
E + Q ++ N L ELPIL+
Sbjct: 174 EEEFNKAQTVFEDLNQELLEELPILY 199
>Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1177
Score = 55.8 bits (133), Expect = 1e-07
Identities = 24/52 (46%), Positives = 35/52 (67%), Gaps = 1/52 (1%)
Query: 375 ALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYVELS 426
A+YDY A E +L+F G +I V+++ D WW G NGV G+FP NYV+++
Sbjct: 1118 AMYDYAANNEDELSFSKGQLINVMNKDDP-DWWQGEINGVTGLFPSNYVKMT 1168
>SPBC12C2.05c [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 642
Score = 55.5 bits (132), Expect = 2e-07
Identities = 26/49 (53%), Positives = 33/49 (67%)
Query: 375 ALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYV 423
ALY YTAQ++ +L+ G IIQV +R+ GW G+ NGV G FP NYV
Sbjct: 591 ALYAYTAQSDMELSIQEGDIIQVTNRNAGNGWSEGILNGVTGQFPANYV 639
>Hs21536417 [U] KOG3771 Amphiphysin
Length = 409
Score = 55.1 bits (131), Expect = 2e-07
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 33/228 (14%)
Query: 8 KAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAVNGMLEHQ 67
K + RA + QKL +T D +E + F + +E +L + + Y +V M E
Sbjct: 20 KKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEAS 79
Query: 68 IGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPDLTLIDEK 127
++ + E+++P + N + E+N DL +D
Sbjct: 80 KKLNECLQEVYEPDWPGRDEANK-IAENN-----------------------DLLWMDYH 115
Query: 128 IVKPAQELLNIINY------IRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKKY 181
Q LL + Y I+ KR K +D D + + YE Q KDE K
Sbjct: 116 QKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYD---SARHHYESLQTAKKKDEAKIA 172
Query: 182 KAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLN 229
KAE ++ Q+ ++ N L+ ELP L+ F F S ++ N
Sbjct: 173 KAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEEN 220
>Hs21536415 [U] KOG3771 Amphiphysin
Length = 439
Score = 55.1 bits (131), Expect = 2e-07
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 33/228 (14%)
Query: 8 KAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAVNGMLEHQ 67
K + RA + QKL +T D +E + F + +E +L + + Y +V M E
Sbjct: 20 KKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEAS 79
Query: 68 IGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPDLTLIDEK 127
++ + E+++P + N + E+N DL +D
Sbjct: 80 KKLNECLQEVYEPDWPGRDEANK-IAENN-----------------------DLLWMDYH 115
Query: 128 IVKPAQELLNIINY------IRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKKY 181
Q LL + Y I+ KR K +D D + + YE Q KDE K
Sbjct: 116 QKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYD---SARHHYESLQTAKKKDEAKIA 172
Query: 182 KAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLN 229
KAE ++ Q+ ++ N L+ ELP L+ F F S ++ N
Sbjct: 173 KAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEEN 220
>Hs21536413 [U] KOG3771 Amphiphysin
Length = 475
Score = 55.1 bits (131), Expect = 2e-07
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 33/228 (14%)
Query: 8 KAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAVNGMLEHQ 67
K + RA + QKL +T D +E + F + +E +L + + Y +V M E
Sbjct: 20 KKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEAS 79
Query: 68 IGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPDLTLIDEK 127
++ + E+++P + N + E+N DL +D
Sbjct: 80 KKLNECLQEVYEPDWPGRDEANK-IAENN-----------------------DLLWMDYH 115
Query: 128 IVKPAQELLNIINY------IRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKKY 181
Q LL + Y I+ KR K +D D + + YE Q KDE K
Sbjct: 116 QKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYD---SARHHYESLQTAKKKDEAKIA 172
Query: 182 KAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLN 229
KAE ++ Q+ ++ N L+ ELP L+ F F S ++ N
Sbjct: 173 KAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEEN 220
>Hs21536411 [U] KOG3771 Amphiphysin
Length = 482
Score = 55.1 bits (131), Expect = 2e-07
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 33/228 (14%)
Query: 8 KAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAVNGMLEHQ 67
K + RA + QKL +T D +E + F + +E +L + + Y +V M E
Sbjct: 20 KKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEAS 79
Query: 68 IGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPDLTLIDEK 127
++ + E+++P + N + E+N DL +D
Sbjct: 80 KKLNECLQEVYEPDWPGRDEANK-IAENN-----------------------DLLWMDYH 115
Query: 128 IVKPAQELLNIINY------IRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKKY 181
Q LL + Y I+ KR K +D D + + YE Q KDE K
Sbjct: 116 QKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYD---SARHHYESLQTAKKKDEAKIA 172
Query: 182 KAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLN 229
KAE ++ Q+ ++ N L+ ELP L+ F F S ++ N
Sbjct: 173 KAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEEN 220
>Hs21536409 [U] KOG3771 Amphiphysin
Length = 518
Score = 55.1 bits (131), Expect = 2e-07
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 33/228 (14%)
Query: 8 KAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAVNGMLEHQ 67
K + RA + QKL +T D +E + F + +E +L + + Y +V M E
Sbjct: 20 KKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEAS 79
Query: 68 IGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPDLTLIDEK 127
++ + E+++P + N + E+N DL +D
Sbjct: 80 KKLNECLQEVYEPDWPGRDEANK-IAENN-----------------------DLLWMDYH 115
Query: 128 IVKPAQELLNIINY------IRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKKY 181
Q LL + Y I+ KR K +D D + + YE Q KDE K
Sbjct: 116 QKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYD---SARHHYESLQTAKKKDEAKIA 172
Query: 182 KAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLN 229
KAE ++ Q+ ++ N L+ ELP L+ F F S ++ N
Sbjct: 173 KAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEEN 220
>Hs21536407 [U] KOG3771 Amphiphysin
Length = 497
Score = 55.1 bits (131), Expect = 2e-07
Identities = 55/228 (24%), Positives = 90/228 (39%), Gaps = 33/228 (14%)
Query: 8 KAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAVNGMLEHQ 67
K + RA + QKL +T D +E + F + +E +L + + Y +V M E
Sbjct: 20 KKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEAS 79
Query: 68 IGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPDLTLIDEK 127
++ + E+++P + N + E+N DL +D
Sbjct: 80 KKLNECLQEVYEPDWPGRDEANK-IAENN-----------------------DLLWMDYH 115
Query: 128 IVKPAQELLNIINY------IRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKKY 181
Q LL + Y I+ KR K +D D + + YE Q KDE K
Sbjct: 116 QKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYD---SARHHYESLQTAKKKDEAKIA 172
Query: 182 KAEAQVAVMQQEYDYYNDMLKTELPILFQLESEFVKPLFVSFYYMQLN 229
KAE ++ Q+ ++ N L+ ELP L+ F F S ++ N
Sbjct: 173 KAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEEN 220
>SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 296
Score = 54.3 bits (129), Expect = 3e-07
Identities = 29/67 (43%), Positives = 38/67 (56%), Gaps = 3/67 (4%)
Query: 361 SYTPPTSA--GVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVF 418
SY P +A VE A+YD+ GDL F AG +I V++ + WW G NG +G+F
Sbjct: 131 SYPGPNTAHKNVERVLAMYDFPGPDAGDLGFHAGEVIIVLEHVNN-DWWRGELNGKEGIF 189
Query: 419 PGNYVEL 425
P NYV L
Sbjct: 190 PSNYVRL 196
>Hs4826844 [Z] KOG0162 Myosin class I heavy chain
Length = 1109
Score = 54.3 bits (129), Expect = 3e-07
Identities = 26/60 (43%), Positives = 33/60 (54%), Gaps = 1/60 (1%)
Query: 364 PPTSAGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYV 423
P V C ALY Y AQ +L+F A II ++ + D +GWW G G G+FP NYV
Sbjct: 1048 PKPKPQVPQCKALYAYDAQDTDELSFNANDIIDII-KEDPSGWWTGRLRGKPGLFPNNYV 1106
>Hs22051526 [Z] KOG0162 Myosin class I heavy chain
Length = 1077
Score = 54.3 bits (129), Expect = 3e-07
Identities = 23/52 (44%), Positives = 33/52 (63%), Gaps = 1/52 (1%)
Query: 373 CTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYVE 424
C ALY Y Q +L+F +I+++ D +GWW G +G +G+FPGNYVE
Sbjct: 1025 CRALYQYVGQDVDELSFNVNEVIEIL-MEDPSGWWKGRLHGQEGLFPGNYVE 1075
>CE29545 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 469
Score = 53.9 bits (128), Expect = 4e-07
Identities = 33/78 (42%), Positives = 44/78 (56%), Gaps = 11/78 (14%)
Query: 356 TATQASYTPP----TSAG------VETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAG 405
T + +S PP TSAG +E LYDY A E +LT AI+ V+ ++D
Sbjct: 390 TESYSSSQPPSLFDTSAGWMPNEYLEKVRVLYDYDAAKEDELTLRENAIVYVLKKNDD-D 448
Query: 406 WWVGVYNGVQGVFPGNYV 423
W+ GV +GV G+FPGNYV
Sbjct: 449 WYEGVLDGVTGLFPGNYV 466
>CE05763 [Z] KOG0162 Myosin class I heavy chain
Length = 1100
Score = 53.9 bits (128), Expect = 4e-07
Identities = 25/50 (50%), Positives = 36/50 (72%), Gaps = 1/50 (2%)
Query: 375 ALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYVE 424
A+Y Y AQ +L+F AGA I+++++ DA+GWW G N G+FPGNYV+
Sbjct: 1051 AVYPYEAQDVDELSFEAGAEIELMNK-DASGWWQGKVNNRVGLFPGNYVK 1099
>SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein
Length = 430
Score = 52.8 bits (125), Expect = 1e-06
Identities = 25/61 (40%), Positives = 35/61 (56%), Gaps = 1/61 (1%)
Query: 367 SAGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDA-AGWWVGVYNGVQGVFPGNYVEL 425
S G A+Y + + GDL+F G II +V+RS + WW G +G+FP NYV+L
Sbjct: 370 SLGPNQARAMYSFAGEQPGDLSFQKGDIIDIVERSGSHDDWWTGRIGYREGIFPANYVKL 429
Query: 426 S 426
S
Sbjct: 430 S 430
>Hs7662296 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 684
Score = 52.8 bits (125), Expect = 1e-06
Identities = 31/76 (40%), Positives = 43/76 (55%), Gaps = 2/76 (2%)
Query: 351 NSVPTTATQASYTPPTSAGVETCTALYDYTAQAEGDLTFPAGAIIQVVDR--SDAAGWWV 408
+S T A S + A V ALYDY Q + +L+FP GAII+++++ D G+W
Sbjct: 494 SSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWE 553
Query: 409 GVYNGVQGVFPGNYVE 424
G +NG GVFP VE
Sbjct: 554 GEFNGRIGVFPSVLVE 569
>7298751 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 52.4 bits (124), Expect = 1e-06
Identities = 27/75 (36%), Positives = 42/75 (56%), Gaps = 3/75 (4%)
Query: 351 NSVPTTATQASYTPPTSAG-VETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVG 409
+++ T++ A+ T+AG VE A Y Y + EGDL+F AG ++ V+ + WW G
Sbjct: 761 DNINTSSIPAASADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKE--GEWWTG 818
Query: 410 VYNGVQGVFPGNYVE 424
G+FP NYV+
Sbjct: 819 TIGSRTGMFPSNYVQ 833
Score = 51.6 bits (122), Expect = 2e-06
Identities = 29/73 (39%), Positives = 37/73 (49%), Gaps = 1/73 (1%)
Query: 351 NSVPTTATQASYTPPTSAGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGV 410
NS T S T ++ ALY Y AQ + +L+F II V+ R D WW G
Sbjct: 1008 NSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGR-DEPEWWRGE 1066
Query: 411 YNGVQGVFPGNYV 423
NG+ G+FP NYV
Sbjct: 1067 LNGLSGLFPSNYV 1079
>Hs7705296 [U] KOG3771 Amphiphysin
Length = 564
Score = 52.0 bits (123), Expect = 2e-06
Identities = 51/206 (24%), Positives = 84/206 (40%), Gaps = 22/206 (10%)
Query: 4 KGFTKAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAVNGM 63
K K +RA + QKL +T D +E + F + ++E KL + K + +AV M
Sbjct: 15 KQVQKKFSRAQEKVLQKLGKAVETKDERFEQSASNFYQQQAEGHKLYKDLKNFLSAVKVM 74
Query: 64 LEHQIGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPDLTL 123
E S+ + EI+ + E+ AIV +
Sbjct: 75 HESSKRVSETLQEIYS------------------SEWDGHEELKAIVWNNDLLWEDYEEK 116
Query: 124 IDEKIVKPAQELLNIINYIRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKKYKA 183
+ ++ V+ + + + I++ KR K +D D + + E QN KDE K KA
Sbjct: 117 LADQAVRTMEIYVAQFSEIKERIAKRGRKLVDYD---SARHHLEAVQN-AKKDEAKTAKA 172
Query: 184 EAQVAVMQQEYDYYNDMLKTELPILF 209
E + Q ++ N L ELPIL+
Sbjct: 173 EEEFNKAQTVFEDLNQELLEELPILY 198
>Hs7661670 [S] KOG1843 Uncharacterized conserved protein
Length = 246
Score = 52.0 bits (123), Expect = 2e-06
Identities = 24/54 (44%), Positives = 32/54 (58%), Gaps = 1/54 (1%)
Query: 374 TALYDYTAQAEGDLTFPAGAIIQVVDRSDA-AGWWVGVYNGVQGVFPGNYVELS 426
TALY + Q GDL F AG I V+ ++D+ WW G G G+FP NYV ++
Sbjct: 193 TALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVTMN 246
>Hs4505869 [I] KOG1264 Phospholipase C
Length = 1290
Score = 51.6 bits (122), Expect = 2e-06
Identities = 27/51 (52%), Positives = 34/51 (65%), Gaps = 2/51 (3%)
Query: 375 ALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGV-FPGNYVE 424
AL+DY AQ E +LTF AIIQ V++ + GWW G Y G + + FP NYVE
Sbjct: 798 ALFDYKAQREDELTFIKSAIIQNVEKQE-GGWWRGDYGGKKQLWFPSNYVE 847
>CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 443
Score = 51.2 bits (121), Expect = 3e-06
Identities = 23/53 (43%), Positives = 35/53 (65%), Gaps = 1/53 (1%)
Query: 373 CTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYVEL 425
C AL+D+ AQ+EG+L F G +I++V + D W+ G NG G+FP YV++
Sbjct: 387 CRALFDFDAQSEGELDFKEGTLIELVSQID-ENWYEGRVNGKTGLFPVTYVQV 438
>7303429 [U] KOG3771 Amphiphysin
Length = 602
Score = 51.2 bits (121), Expect = 3e-06
Identities = 44/209 (21%), Positives = 76/209 (36%), Gaps = 19/209 (9%)
Query: 1 MSFKGFTKAVARAPQSFRQKLNMGQQTVDPVYEDADRRFKELESETKKLSDESKRYFNAV 60
M K K RA + Q L +T D +++D F ++ +L E Y V
Sbjct: 8 MLAKSVQKHAGRAKEKILQNLGKVDRTADEIFDDHLNNFNRQQASANRLQKEFNNYIRCV 67
Query: 61 NGMLEHQIGFSKAMSEIFKPISGKMSDPNAAVPEDNPEGIEASEQYSAIVSELQATLKPD 120
++ EI++P G +A + + L A
Sbjct: 68 RAAQAASKTLMDSVCEIYEP---------------QWSGYDALQAQTGASESLWADFAHK 112
Query: 121 LTLIDEKIVKPAQELLNIINYIRKMSTKRNHKKLDLDRSLNTYNKYEQKQNPTPKDEEKK 180
L ++++ P ++K KRN K +D D +++ + N KD+ K
Sbjct: 113 L---GDQVLIPLNTYTGQFPEMKKKVEKRNRKLIDYDGQRHSFQNLQANANKR-KDDVKL 168
Query: 181 YKAEAQVAVMQQEYDYYNDMLKTELPILF 209
K Q+ ++ Y+ N L ELP L+
Sbjct: 169 TKGREQLEEARRTYEILNTELHDELPALY 197
>7294461 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 531
Score = 50.8 bits (120), Expect = 4e-06
Identities = 25/52 (48%), Positives = 34/52 (65%), Gaps = 2/52 (3%)
Query: 375 ALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVY-NGVQGVFPGNYVEL 425
ALYDY A E ++TF G +I +D+ D GWW G+ +G G+FP NYVE+
Sbjct: 479 ALYDYQAADETEITFDPGDVITHIDQIDE-GWWQGLGPDGTYGLFPANYVEI 529
>Hs4885609 [T] KOG0197 Tyrosine kinases
Length = 536
Score = 50.4 bits (119), Expect = 5e-06
Identities = 26/70 (37%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 356 TATQASYTPPTSAGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWV--GVYNG 413
T T P + GV T ALYDY ++ E DL+F G +Q+V+ ++ WW+ + G
Sbjct: 72 TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTE-GDWWLAHSLSTG 130
Query: 414 VQGVFPGNYV 423
G P NYV
Sbjct: 131 QTGYIPSNYV 140
>Hs11321634 [T] KOG4348 Adaptor protein CMS/SETA
Length = 639
Score = 50.4 bits (119), Expect = 5e-06
Identities = 23/53 (43%), Positives = 30/53 (56%), Gaps = 1/53 (1%)
Query: 371 ETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDA-AGWWVGVYNGVQGVFPGNY 422
E C L+ Y E +LTF G II ++ + AGWW G NG +GVFP N+
Sbjct: 272 EYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNF 324
>7297777 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 689
Score = 50.4 bits (119), Expect = 5e-06
Identities = 25/49 (51%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 375 ALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQGVFPGNYV 423
ALYD+ A E +LTF AG II V+D SD WW G +G+FP N+V
Sbjct: 239 ALYDFEAAEENELTFFAGEIIHVLDDSD-PNWWKGYNQRGEGLFPSNFV 286
>SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding proteins
Length = 857
Score = 49.7 bits (117), Expect = 8e-06
Identities = 27/69 (39%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Query: 356 TATQASYTPPTSAGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAAGWWVGVYNGVQ 415
TA P ++ A+YDY AQ + +L+F II VD D WW G +G +
Sbjct: 788 TANNPPAEPQAGGPGKSVKAIYDYQAQEDNELSFFEDEIIANVDCVDP-NWWEGECHGHR 846
Query: 416 GVFPGNYVE 424
G+FP NYVE
Sbjct: 847 GLFPSNYVE 855
>Hs20536136 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 1036
Score = 49.7 bits (117), Expect = 8e-06
Identities = 24/61 (39%), Positives = 33/61 (53%), Gaps = 4/61 (6%)
Query: 367 SAGVETCTALYDYTAQAEGDLTFPAGAIIQVVDRSDAA----GWWVGVYNGVQGVFPGNY 422
SAG ALYDY A+ E +L+ G +++V+ + A GWW G G+FP NY
Sbjct: 37 SAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANY 96
Query: 423 V 423
V
Sbjct: 97 V 97
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.314 0.132 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,789,224
Number of Sequences: 60738
Number of extensions: 959556
Number of successful extensions: 3240
Number of sequences better than 1.0e-05: 42
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 3170
Number of HSP's gapped (non-prelim): 73
length of query: 428
length of database: 30,389,216
effective HSP length: 109
effective length of query: 319
effective length of database: 23,768,774
effective search space: 7582238906
effective search space used: 7582238906
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)