ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV0811 good TZ KOG2710 Cytoskeleton Rho GTPase-activating protein
r_klactV0811 good TZ KOG2710 Signal transduction mechanisms Rho GTPase-activating protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV0811 284154 285812 553
(553 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR389w [TZ] KOG2710 Rho GTPase-activating protein 361 2e-99
YOR134w [TZ] KOG2710 Rho GTPase-activating protein 221 2e-57
SPBC17F3.01c [TZ] KOG2710 Rho GTPase-activating protein 105 2e-22
Hs7382484 [TZ] KOG2710 Rho GTPase-activating protein 67 5e-11
Hs7382482 [TZ] KOG2710 Rho GTPase-activating protein 67 5e-11
Hs7382480 [TZ] KOG2710 Rho GTPase-activating protein 67 5e-11
Hs7382478 [TZ] KOG2710 Rho GTPase-activating protein 67 5e-11
Hs4502223 [TZ] KOG2710 Rho GTPase-activating protein 67 5e-11
Hs7706107 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 64 5e-10
Hs13775230 [T] KOG4270 GTPase-activator protein 64 8e-10
Hs5902012_2 [T] KOG1453 Chimaerin and related Rho GTPase activat... 62 2e-09
7304324 [TZ] KOG2710 Rho GTPase-activating protein 59 1e-08
Hs7661882 [T] KOG4270 GTPase-activator protein 58 4e-08
Hs4758882 [T] KOG1453 Chimaerin and related Rho GTPase activatin... 58 4e-08
Hs22050706 [T] KOG4271 Rho-GTPase activating protein 55 3e-07
CE27576 [TZ] KOG2710 Rho GTPase-activating protein 55 4e-07
CE11336 [TZ] KOG2710 Rho GTPase-activating protein 55 4e-07
Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 54 5e-07
Hs4758750_2 [T] KOG1453 Chimaerin and related Rho GTPase activat... 54 5e-07
Hs14765644 [T] KOG1453 Chimaerin and related Rho GTPase activati... 53 1e-06
SPAC26A3.09 [T] KOG4269 Rac GTPase-activating protein BCR/ABR 53 1e-06
Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 52 2e-06
Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein 52 2e-06
At5g61530 [T] KOG4270 GTPase-activator protein 52 2e-06
SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein 51 4e-06
Hs21450649 [TZ] KOG2710 Rho GTPase-activating protein 51 4e-06
Hs20536040 [T] KOG4270 GTPase-activator protein 51 5e-06
CE21517 [T] KOG4270 GTPase-activator protein 51 5e-06
7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr 50 7e-06
Hs5803145 [T] KOG4370 Ral-GTPase effector RLIP76 50 9e-06
CE16171 [T] KOG4271 Rho-GTPase activating protein 50 9e-06
>YDR389w [TZ] KOG2710 Rho GTPase-activating protein
Length = 654
Score = 361 bits (926), Expect = 2e-99
Identities = 254/646 (39%), Positives = 333/646 (51%), Gaps = 119/646 (18%)
Query: 18 SPSKNQLTNWWRQFRNNPKSVSSETLSENR------------------------------ 47
SPSK + ++W+QF NNPKS+SSE ++ R
Sbjct: 16 SPSKGHVPSFWKQFINNPKSMSSENITVPRSPTSLSRNAQPTTLKRPPLSSRPYSYNTPT 75
Query: 48 --RKGNGSSVSRTNGHGSIPAFRDPSDEDFKEYRDAFLNQRHGFSGQVFNVPLSQSLSVA 105
RK S + N + + + P E FK YRD FL+ R+GF+G+VF V L++SLSVA
Sbjct: 76 KDRKSFSKSAKQNNNNNNANSGTSPHAE-FKNYRDMFLSNRNGFTGRVFGVTLAESLSVA 134
Query: 106 SAEVIVQTELSSFGRIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNY 165
SAEVIVQ+EL SFGRIPIVVAKCGAYLK GLETSGIFRIAGN KR+K LQYIFS+PP+Y
Sbjct: 135 SAEVIVQSELVSFGRIPIVVAKCGAYLKANGLETSGIFRIAGNGKRVKALQYIFSSPPDY 194
Query: 166 GAKFSNWDEFTVHDVASLLRRFLNHLQEPLIPLALYDSFRKPLIDRPRIIQHL--KKASN 223
G KF++W+ +TVHDVASLLRR+LN+L EPLIPL+LY+ FR PL RPRI++H+ + S+
Sbjct: 195 GTKFNDWETYTVHDVASLLRRYLNNLAEPLIPLSLYEQFRNPLRSRPRILRHMLTHEVSH 254
Query: 224 DGSSQQSDEADDPEPREVEDYDVQEGAEINSAAK--ELXXXXXXXXXXXLAKDIKNAIKD 281
+++ ++ + D +G AK E L +DI+ AIK+
Sbjct: 255 PNANKTNNVTVKSSRQNYNDDGANDGDIEKEDAKDDEEKRRRKIRHKRRLTRDIRAAIKE 314
Query: 282 YDQLFELLPDDPRQXXXXXXXXXXXFAQQSDKNLMTSANLAAIFQPSMISHPDHDMDPRE 341
Y++LF L +D +Q FA+QS NLM+ NLAAIFQPS++SHP HDMDP+E
Sbjct: 315 YEELFVTLSNDTKQLTIYLLDLLSLFARQSQFNLMSGRNLAAIFQPSILSHPQHDMDPKE 374
Query: 342 YEISRLVVEFLLCYSYXXXXXXXXXXXXXPQSITII------SDKEKPSP-------SPD 388
YE+SRLVVEFL+ YSY Q DK+K P S D
Sbjct: 375 YELSRLVVEFLIEYSYKLLPHLLKLAKREQQERLSTENKKNNGDKQKTDPIEIPKITSSD 434
Query: 389 CDEDVEPSK------ENXXXXXXXXXXXXXXXKFNESDI---GVLTPPDPHYLEVPKTRP 439
V +K N N SD+ +L PP + RP
Sbjct: 435 SPPIVSSNKNPPAIDNNNKLDHTTLSPISTSIPENSSDLQTSKMLKPP-------KQRRP 487
Query: 440 YSKSLSSANAPSDMIAS--RRHSKIPFLNKL-FVSDTEDEYDSSS--------------- 481
+SKS S P D+IAS RR S P+L+K +SDT D D ++
Sbjct: 488 HSKSFGSTPVPPDVIASNKRRTSLFPWLHKPGILSDTGDNGDLTATEAEGDDYEEENVDP 547
Query: 482 ---RPSS--------------PMLRKT---GSTNSAKMLQLPSIVGISKDDFPT------ 515
PSS P + ++ STNS+ + S++ S +D
Sbjct: 548 YGQSPSSVHSGSLPKQHYLPIPRMNRSLSGNSTNSSFNTRPISMILTSGNDNSADQLELL 607
Query: 516 SKTDSD---------FEDGQEERQPRSKKRESWLQRLKSHSRSSIR 552
S T S+ ED +ER RS+KRESW QRL S S S+ R
Sbjct: 608 SNTHSNNERSNALPLTEDDGDERNSRSRKRESWFQRLTSRSGSANR 653
>YOR134w [TZ] KOG2710 Rho GTPase-activating protein
Length = 409
Score = 221 bits (563), Expect = 2e-57
Identities = 158/482 (32%), Positives = 227/482 (46%), Gaps = 102/482 (21%)
Query: 71 SDEDFKEYRDAFLNQRHGFSGQVFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAKCGA 130
S + K+ RD F N ++ F G+VF V L +SL VA EVI+Q + G IP+V+AK G
Sbjct: 25 SSVEGKKDRDTFTNLQNEFDGKVFGVSLEESLKVAQEEVIIQKSTNEIGSIPVVIAKSGK 84
Query: 131 YLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRFLNH 190
YLK+ L+T+GIFRIAG+ KR++ELQ +FS PP+YG KF W +F VHD+A+LL+R+LN
Sbjct: 85 YLKENALDTTGIFRIAGSNKRVRELQAVFSKPPDYGRKFEGWCDFNVHDIATLLKRYLNS 144
Query: 191 LQEPLIPLALYDSFRKPLIDRPRIIQHLKKASNDGSSQQSDEADDPEPREVEDYDVQEGA 250
L EPL+PLALYD FR P+++ P+I +H ++ ++DY+
Sbjct: 145 LSEPLVPLALYDIFRNPILENPKINEHKEQI-------------------IKDYE----- 180
Query: 251 EINSAAKELXXXXXXXXXXXLAKDIKNAIKDYDQLFELLPDDPRQXXXXXXXXXXXFAQQ 310
++ LLP R FA+
Sbjct: 181 ---------------------------------DIYMLLPQQNRHLILYLAALLNLFARN 207
Query: 311 SDKNLMTSANLAAIFQPSMISHPDHDMDPREYEISRLVVEFLLCY-SYXXXXXXXXXXXX 369
KNLM+++NLAAI QPS++SHP +M P+EYE SR V+EFL+ + S
Sbjct: 208 EKKNLMSASNLAAIVQPSLLSHPKDEMCPKEYEASRTVIEFLILHASDIIPNTEKANKDT 267
Query: 370 XPQSITIISDKEKPSPSPDCDEDVEPSKENXXXXXXXXXXXXXXXKFNESDIGVLTPPDP 429
P + T+ P D D E F I D
Sbjct: 268 MPHAGTVAKFNNITVPEMAIDSDEE--------------------DFVHPSI------DD 301
Query: 430 HYLEVPKTRPYSKSLSSANAPSDMIASRRHSKIPFLNKLFVSDTEDEYDSSSRPSSPMLR 489
H L P S++LS +N + I H + LF S + + + S P S
Sbjct: 302 HML------PRSRALSDSN--NFTIHHHHHHH----HALFPSPIDFDNNGLSVPRS---- 345
Query: 490 KTGSTNSAKML--QLPSIVGISKDDFPTSKTDSDFEDGQEERQPRSKKRESWLQRLKSHS 547
G T SA+ L +L ++G + T D + E + + K+R+SWL+RL S S
Sbjct: 346 FKGRTLSAESLSPRLSKLLGNVGNSSNTGIKDPTERVPRGEHKTKHKQRQSWLRRLTSPS 405
Query: 548 RS 549
R+
Sbjct: 406 RT 407
>SPBC17F3.01c [TZ] KOG2710 Rho GTPase-activating protein
Length = 327
Score = 105 bits (262), Expect = 2e-22
Identities = 52/120 (43%), Positives = 80/120 (66%), Gaps = 4/120 (3%)
Query: 92 QVFNVPLSQSLSVASAEVIVQT---ELSSFGRIPIVVAKCGAYLKQQGLETSGIFRIAGN 148
++F + L+++L V+ + + E +G IP VVAKCG +LKQ + GIFR+ G+
Sbjct: 35 KLFGLSLTRALEVSKVAIFLTRRDGEKVFYGYIPAVVAKCGFFLKQNATQVKGIFRVNGS 94
Query: 149 TKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRFLNHLQEPLIPLALYDSFRKPL 208
+KRI+ LQ FST P+YG F +W+ +TVHD A++ RRF+N + E +IPL Y+ FR+P+
Sbjct: 95 SKRIQILQKAFSTGPDYGRSF-DWEGYTVHDAANVFRRFINLMPEHVIPLEYYERFREPM 153
Score = 63.5 bits (153), Expect = 8e-10
Identities = 31/75 (41%), Positives = 46/75 (61%)
Query: 279 IKDYDQLFELLPDDPRQXXXXXXXXXXXFAQQSDKNLMTSANLAAIFQPSMISHPDHDMD 338
++ Y + + LP RQ FA S KNLMT+ NLAAIFQP ++SHPDH++
Sbjct: 164 VEMYRRRIDELPIPNRQLLLYLLDLLSVFAMNSSKNLMTADNLAAIFQPGILSHPDHEVY 223
Query: 339 PREYEISRLVVEFLL 353
++Y+IS+ + FL+
Sbjct: 224 SKDYQISQTALLFLI 238
>Hs7382484 [TZ] KOG2710 Rho GTPase-activating protein
Length = 765
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/205 (26%), Positives = 88/205 (42%), Gaps = 17/205 (8%)
Query: 10 ADGFSHSQSPSKNQLTNWWRQFRNNPKSVSSETLSENRRKGNGSSVSRTNGHG--SIPAF 67
A F S P N+ N N+ S +SET +E+ R G S+ +
Sbjct: 308 ASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSI 367
Query: 68 RDPSDEDFKEYRDAFLNQRHGFSGQVFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAK 127
D D NQ ++P A + + ++P +V
Sbjct: 368 TDLDD-----------NQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS 416
Query: 128 CGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRF 187
C +L++ GL+T GIFR+ + KR+++L+ F G S +E +VHDVA+LL+ F
Sbjct: 417 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR----GIDVSLEEEHSVHDVAALLKEF 472
Query: 188 LNHLQEPLIPLALYDSFRKPLIDRP 212
L + +PL+ LY +F L+ P
Sbjct: 473 LRDMPDPLLTRELYTAFINTLLLEP 497
>Hs7382482 [TZ] KOG2710 Rho GTPase-activating protein
Length = 974
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/205 (26%), Positives = 88/205 (42%), Gaps = 17/205 (8%)
Query: 10 ADGFSHSQSPSKNQLTNWWRQFRNNPKSVSSETLSENRRKGNGSSVSRTNGHG--SIPAF 67
A F S P N+ N N+ S +SET +E+ R G S+ +
Sbjct: 308 ASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSI 367
Query: 68 RDPSDEDFKEYRDAFLNQRHGFSGQVFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAK 127
D D NQ ++P A + + ++P +V
Sbjct: 368 TDLDD-----------NQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS 416
Query: 128 CGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRF 187
C +L++ GL+T GIFR+ + KR+++L+ F G S +E +VHDVA+LL+ F
Sbjct: 417 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR----GIDVSLEEEHSVHDVAALLKEF 472
Query: 188 LNHLQEPLIPLALYDSFRKPLIDRP 212
L + +PL+ LY +F L+ P
Sbjct: 473 LRDMPDPLLTRELYTAFINTLLLEP 497
>Hs7382480 [TZ] KOG2710 Rho GTPase-activating protein
Length = 771
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/205 (26%), Positives = 88/205 (42%), Gaps = 17/205 (8%)
Query: 10 ADGFSHSQSPSKNQLTNWWRQFRNNPKSVSSETLSENRRKGNGSSVSRTNGHG--SIPAF 67
A F S P N+ N N+ S +SET +E+ R G S+ +
Sbjct: 105 ASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSI 164
Query: 68 RDPSDEDFKEYRDAFLNQRHGFSGQVFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAK 127
D D NQ ++P A + + ++P +V
Sbjct: 165 TDLDD-----------NQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS 213
Query: 128 CGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRF 187
C +L++ GL+T GIFR+ + KR+++L+ F G S +E +VHDVA+LL+ F
Sbjct: 214 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR----GIDVSLEEEHSVHDVAALLKEF 269
Query: 188 LNHLQEPLIPLALYDSFRKPLIDRP 212
L + +PL+ LY +F L+ P
Sbjct: 270 LRDMPDPLLTRELYTAFINTLLLEP 294
>Hs7382478 [TZ] KOG2710 Rho GTPase-activating protein
Length = 562
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/205 (26%), Positives = 88/205 (42%), Gaps = 17/205 (8%)
Query: 10 ADGFSHSQSPSKNQLTNWWRQFRNNPKSVSSETLSENRRKGNGSSVSRTNGHG--SIPAF 67
A F S P N+ N N+ S +SET +E+ R G S+ +
Sbjct: 105 ASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSI 164
Query: 68 RDPSDEDFKEYRDAFLNQRHGFSGQVFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAK 127
D D NQ ++P A + + ++P +V
Sbjct: 165 TDLDD-----------NQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS 213
Query: 128 CGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRF 187
C +L++ GL+T GIFR+ + KR+++L+ F G S +E +VHDVA+LL+ F
Sbjct: 214 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR----GIDVSLEEEHSVHDVAALLKEF 269
Query: 188 LNHLQEPLIPLALYDSFRKPLIDRP 212
L + +PL+ LY +F L+ P
Sbjct: 270 LRDMPDPLLTRELYTAFINTLLLEP 294
>Hs4502223 [TZ] KOG2710 Rho GTPase-activating protein
Length = 480
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/205 (26%), Positives = 88/205 (42%), Gaps = 17/205 (8%)
Query: 10 ADGFSHSQSPSKNQLTNWWRQFRNNPKSVSSETLSENRRKGNGSSVSRTNGHG--SIPAF 67
A F S P N+ N N+ S +SET +E+ R G S+ +
Sbjct: 130 ASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRGAMSVDSI 189
Query: 68 RDPSDEDFKEYRDAFLNQRHGFSGQVFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAK 127
D D NQ ++P A + + ++P +V
Sbjct: 190 TDLDD-----------NQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDS 238
Query: 128 CGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRF 187
C +L++ GL+T GIFR+ + KR+++L+ F G S +E +VHDVA+LL+ F
Sbjct: 239 CCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR----GIDVSLEEEHSVHDVAALLKEF 294
Query: 188 LNHLQEPLIPLALYDSFRKPLIDRP 212
L + +PL+ LY +F L+ P
Sbjct: 295 LRDMPDPLLTRELYTAFINTLLLEP 319
>Hs7706107 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 970
Score = 64.3 bits (155), Expect = 5e-10
Identities = 32/84 (38%), Positives = 49/84 (58%), Gaps = 4/84 (4%)
Query: 121 IPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDV 180
+P VV KC A ++ + L+ GI+R++G+ R++ L F G + HDV
Sbjct: 564 VPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFEN----GRALVELSGNSPHDV 619
Query: 181 ASLLRRFLNHLQEPLIPLALYDSF 204
+S+L+RFL L EP+IP LYD+F
Sbjct: 620 SSVLKRFLQELTEPVIPFHLYDAF 643
>Hs13775230 [T] KOG4270 GTPase-activator protein
Length = 655
Score = 63.5 bits (153), Expect = 8e-10
Identities = 34/83 (40%), Positives = 50/83 (59%), Gaps = 4/83 (4%)
Query: 122 PIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVA 181
P++V +C +++Q+GL+ G+FR+ G +KELQ F + G K S VH VA
Sbjct: 60 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAF----DCGEKPSFDSNTDVHTVA 115
Query: 182 SLLRRFLNHLQEPLIPLALYDSF 204
SLL+ +L L EP+IP A Y+ F
Sbjct: 116 SLLKLYLRELPEPVIPYAKYEDF 138
>Hs5902012_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1223
Score = 62.0 bits (149), Expect = 2e-09
Identities = 31/88 (35%), Positives = 53/88 (60%), Gaps = 4/88 (4%)
Query: 121 IPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDV 180
+P+VV K Y++ GL T GI+R +G+T +IKEL+ T A+ N D++ +H +
Sbjct: 750 VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDT----DAESVNLDDYNIHVI 805
Query: 181 ASLLRRFLNHLQEPLIPLALYDSFRKPL 208
AS+ +++L L PL+ LY+ F + +
Sbjct: 806 ASVFKQWLRDLPNPLMTFELYEEFLRAM 833
>7304324 [TZ] KOG2710 Rho GTPase-activating protein
Length = 205
Score = 59.3 bits (142), Expect = 1e-08
Identities = 33/86 (38%), Positives = 49/86 (56%), Gaps = 4/86 (4%)
Query: 121 IPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDV 180
+PI V C YL+ GL+ G+FR++ + KR+K+L+ F +G + HDV
Sbjct: 2 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISV----DTCPHDV 57
Query: 181 ASLLRRFLNHLQEPLIPLALYDSFRK 206
A+LL+ FL L EPL+ LY +F K
Sbjct: 58 ATLLKEFLRDLPEPLLCNTLYLTFLK 83
>Hs7661882 [T] KOG4270 GTPase-activator protein
Length = 638
Score = 57.8 bits (138), Expect = 4e-08
Identities = 30/84 (35%), Positives = 47/84 (55%), Gaps = 4/84 (4%)
Query: 121 IPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDV 180
+PI+V KC ++ + G GIFR+ G +K+L+ F G + S + VH V
Sbjct: 169 VPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDA----GERPSFDRDTDVHTV 224
Query: 181 ASLLRRFLNHLQEPLIPLALYDSF 204
ASLL+ +L L EP++P + Y+ F
Sbjct: 225 ASLLKLYLRDLPEPVVPWSQYEGF 248
>Hs4758882 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1261
Score = 57.8 bits (138), Expect = 4e-08
Identities = 91/429 (21%), Positives = 144/429 (33%), Gaps = 81/429 (18%)
Query: 121 IPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDV 180
IP ++ C + ++ + L GI+R+ GN + ++L G + EF+ HD+
Sbjct: 684 IPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCLALEN----GMHLVDISEFSSHDI 739
Query: 181 ASLLRRFLNHLQEPLIPLALYDSFRKPLIDRPRIIQHLKKASNDGSSQQSDEADDPEPRE 240
+L+ +L L EP I LY F ID + IQH+ +E + +
Sbjct: 740 CDVLKLYLRQLPEPFILFRLYKEF----IDLAKEIQHV------------NEEQETKKNS 783
Query: 241 VEDYDVQEGAEINSAAKELXXXXXXXXXXXLAKDIKNAIKDYDQLFELLPDDPRQXXXXX 300
+ED + +I + L LP
Sbjct: 784 LED----------------------KKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFL 821
Query: 301 XXXXXXFAQQSDKNLMTSANLAAIFQPSMI-----SHPDHDMDPREYEISRLVVEFLLCY 355
+++N M S NL IF PS+I + P EY +VEFL+ Y
Sbjct: 822 IVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPQTAPITISSLAEYSNQARLVEFLITY 881
Query: 356 SYXXXXXXXXXXXXXPQ----SITIISDKEKPSP--SPDCDEDVE--------PSKENXX 401
S PQ SI ++ P P SP+ + D+E SKE+
Sbjct: 882 S-----QKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPE-ERDIERSMKSLFFSSKEDIH 935
Query: 402 XXXXXXXXXXXXXKFNESD--------IGVLTPPDPHYLEVPKTRPYSKSLSSANAP--- 450
F ES+ L + S+ + AP
Sbjct: 936 TSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKAPKPL 995
Query: 451 ---SDMIASRRHSKIPFLNKLFVSDTEDEYDSSSRPSSPMLRKTGSTNSAKMLQLPSIVG 507
SD + P VS D +S P+ R G+ N K + P+ G
Sbjct: 996 SLKSDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEG 1055
Query: 508 ISKDDFPTS 516
+++ D T+
Sbjct: 1056 VNRKDAATT 1064
>Hs22050706 [T] KOG4271 Rho-GTPase activating protein
Length = 1499
Score = 55.1 bits (131), Expect = 3e-07
Identities = 27/77 (35%), Positives = 43/77 (55%), Gaps = 3/77 (3%)
Query: 121 IPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDV 180
IPI + +C Y++ GL T GI+R++GN ++ LQ F N +FTV+ V
Sbjct: 1261 IPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEK---DFTVNTV 1317
Query: 181 ASLLRRFLNHLQEPLIP 197
A ++ F + L +PL+P
Sbjct: 1318 AGAMKSFFSELPDPLVP 1334
>CE27576 [TZ] KOG2710 Rho GTPase-activating protein
Length = 793
Score = 54.7 bits (130), Expect = 4e-07
Identities = 30/86 (34%), Positives = 45/86 (51%), Gaps = 1/86 (1%)
Query: 120 RIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTV-H 178
++P +V C YL GL G+FR+AGNTKR ++L+ N E T H
Sbjct: 334 QVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVINDNMVENTTSH 393
Query: 179 DVASLLRRFLNHLQEPLIPLALYDSF 204
DVA+LL+ + L + L+P Y ++
Sbjct: 394 DVATLLKEYFRDLPQSLLPGEHYSAY 419
>CE11336 [TZ] KOG2710 Rho GTPase-activating protein
Length = 553
Score = 54.7 bits (130), Expect = 4e-07
Identities = 30/86 (34%), Positives = 45/86 (51%), Gaps = 1/86 (1%)
Query: 120 RIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTV-H 178
++P +V C YL GL G+FR+AGNTKR ++L+ N E T H
Sbjct: 94 QVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALEKVGGGAVINDNMVENTTSH 153
Query: 179 DVASLLRRFLNHLQEPLIPLALYDSF 204
DVA+LL+ + L + L+P Y ++
Sbjct: 154 DVATLLKEYFRDLPQSLLPGEHYSAY 179
>Hs15723376 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 618
Score = 54.3 bits (129), Expect = 5e-07
Identities = 30/86 (34%), Positives = 46/86 (52%), Gaps = 2/86 (2%)
Query: 120 RIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHD 179
RIP++ K + ++++GLET G+ RI G RIK L G NW+ HD
Sbjct: 296 RIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGT--FNWESVKQHD 353
Query: 180 VASLLRRFLNHLQEPLIPLALYDSFR 205
ASLL+ F+ L +PL+ + +F+
Sbjct: 354 AASLLKLFIRELPQPLLSVEYLKAFQ 379
>Hs4758750_2 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 878
Score = 54.3 bits (129), Expect = 5e-07
Identities = 35/126 (27%), Positives = 63/126 (49%), Gaps = 15/126 (11%)
Query: 109 VIVQTELSSFGRIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAK 168
V V + S +PIV+ K +++ GL T G++R +G R +EL+ T P K
Sbjct: 556 VCVDSLTSDKASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDP-AAVK 614
Query: 169 FSNWDEFTVHDVASLLRRFLNHLQEPLIPLALYDSFRKPLIDRPR----------IIQHL 218
N F +H + +L+++L L EPL+ A Y F + ++ P +++HL
Sbjct: 615 LEN---FPIHAITGVLKQWLRELPEPLMTFAQYGDFLR-AVELPEKQEQLAAIYAVLEHL 670
Query: 219 KKASND 224
+A+++
Sbjct: 671 PEANHN 676
>Hs14765644 [T] KOG1453 Chimaerin and related Rho GTPase activating proteins
Length = 1136
Score = 53.1 bits (126), Expect = 1e-06
Identities = 46/210 (21%), Positives = 80/210 (37%), Gaps = 44/210 (20%)
Query: 121 IPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDV 180
+P +V KC ++++ L T GI+R+ G R+++L F G + + + HD+
Sbjct: 774 VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFEN----GKELVELSQASPHDI 829
Query: 181 ASLLRRFLNHLQEPLIPLALYDSFRKPLIDRPRIIQHLKKASNDGSSQQSDEADDPEPRE 240
+++L+ +L L EPLI LY D + K AS
Sbjct: 830 SNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGR--------------- 874
Query: 241 VEDYDVQEGAEINSAAKELXXXXXXXXXXXLAKDIKNAIKDYDQLFELLPDDPRQXXXXX 300
Q+G+E + A LA ++ ++D LP + R
Sbjct: 875 ------QDGSESEAVA------------VALAGRLRELLRD-------LPPENRASLQYL 909
Query: 301 XXXXXXFAQQSDKNLMTSANLAAIFQPSMI 330
+ N MT NL +F P+++
Sbjct: 910 LRHLRRIVEVEQDNKMTPGNLGIVFGPTLL 939
>SPAC26A3.09 [T] KOG4269 Rac GTPase-activating protein BCR/ABR
Length = 1275
Score = 52.8 bits (125), Expect = 1e-06
Identities = 34/113 (30%), Positives = 65/113 (57%), Gaps = 10/113 (8%)
Query: 93 VFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAKCGAYLKQQGLETS-GIFRIAGNTKR 151
+F +PL+++++++ T+ + G +PIVV +C YL+ E GI+R++G+
Sbjct: 1062 IFGLPLNEAVNIS-------TQFNDSG-LPIVVYRCIEYLESCRAEKEEGIYRLSGSAST 1113
Query: 152 IKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRFLNHLQEPLIPLALYDSF 204
IK L+ F+ +Y S+ +EF VH +A LL+ +L +L L+ +++ F
Sbjct: 1114 IKHLKEQFNEGVDYDLLSSD-EEFDVHVIAGLLKLYLRNLPTNLLDTSMHKLF 1165
>Hs20559247 [T] KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1
Length = 710
Score = 52.4 bits (124), Expect = 2e-06
Identities = 34/113 (30%), Positives = 60/113 (53%), Gaps = 9/113 (7%)
Query: 92 QVFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAKCGAYLKQQGLETSGIFRIAGNTKR 151
++F VPL SL A +V+ T+ +P+V+ + L+++GL+ GI R+ G+ R
Sbjct: 238 RLFGVPLD-SLLEADHKVLPSTQ------VPLVLQALLSCLEKRGLDMEGILRVPGSQAR 290
Query: 152 IKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRFLNHLQEPLIPLALYDSF 204
+K L+ ++ A +WDE +D + LL+RF+ L PL+ +F
Sbjct: 291 VKGLEQ--KLERDFYAGLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAF 341
>Hs19923546 [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 316
Score = 52.4 bits (124), Expect = 2e-06
Identities = 29/114 (25%), Positives = 54/114 (46%), Gaps = 10/114 (8%)
Query: 119 GRIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVH 178
G +P V C ++++ GL+ GI+R++GN I++L++ + S W++ +H
Sbjct: 137 GTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWED--IH 194
Query: 179 DVASLLRRFLNHLQEPLIPLALYDSFRKPLIDRPR--------IIQHLKKASND 224
+ L+ F L EPL ++ F + PR +I+ L K + D
Sbjct: 195 VITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQD 248
>At5g61530 [T] KOG4270 GTPase-activator protein
Length = 384
Score = 52.4 bits (124), Expect = 2e-06
Identities = 37/116 (31%), Positives = 59/116 (49%), Gaps = 5/116 (4%)
Query: 108 EVIVQTELSSFGRIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGA 167
E+ VQ + SS IP+++ KC YL GL + +F+ G+ K I++L ++ P
Sbjct: 150 EITVQRQESS-RPIPLILVKCADYLILTGLNSPNLFKAEGDRKLIQQLVSAYNQDP---- 204
Query: 168 KFSNWDEFTVHDVASLLRRFLNHLQEPLIPLALYDSFRKPLIDRPRIIQHLKKASN 223
+ S + DVA+LL+ +L L PL LY+ + R+ Q L+K SN
Sbjct: 205 RASIPEGVNPVDVAALLKYYLASLPTPLTTFELYNEIKDARSSIHRMRQSLQKLSN 260
>SPBC23G7.08c [T] KOG1450 Predicted Rho GTPase-activating protein
Length = 695
Score = 51.2 bits (121), Expect = 4e-06
Identities = 36/114 (31%), Positives = 55/114 (47%), Gaps = 7/114 (6%)
Query: 97 PLSQSLSVASAEVIVQTELSSFGRIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQ 156
P L A + I+ E S+ IP +V +C + ++ GL GI+R+ ++ R+ L+
Sbjct: 498 PTKSLLFGARLDAIILREHSN---IPNIVMQCTSQVENFGLNLQGIYRVPSSSARVNMLR 554
Query: 157 YIFSTPPNYGAKFSNWDEFTVHDVASLLRRFLNHLQEPLIPLALYDSFRKPLID 210
F P E VH VA LL+ F L+EPLIP D+ ++ ID
Sbjct: 555 SQFENNPLLQLHTPEDYENDVHAVADLLKIFFRELREPLIP----DNHQRDFID 604
>Hs21450649 [TZ] KOG2710 Rho GTPase-activating protein
Length = 411
Score = 51.2 bits (121), Expect = 4e-06
Identities = 29/85 (34%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 120 RIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHD 179
+IP VV C ++++ GL GIF + + +R+++L+ F + G D VHD
Sbjct: 98 QIPQVVEACCQFIEKHGLSAVGIFTLEYSVQRVRQLREEF----DQGLDVVLDDNQNVHD 153
Query: 180 VASLLRRFLNHLQEPLIPLALYDSF 204
VA+LL+ F +++ L+P LY SF
Sbjct: 154 VAALLKEFFRDMKDSLLPDDLYMSF 178
>Hs20536040 [T] KOG4270 GTPase-activator protein
Length = 364
Score = 50.8 bits (120), Expect = 5e-06
Identities = 48/153 (31%), Positives = 69/153 (44%), Gaps = 25/153 (16%)
Query: 73 EDFKEYRDAFLNQRHGFSGQ-VFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAKCGAY 131
ED K+ LN++ F+ Q +F V L + + + L+ G IP VV Y
Sbjct: 29 EDMKKIVAVPLNEQKDFTYQKLFGVSLQE---------LERQGLTENG-IPAVVWNIVEY 78
Query: 132 LKQQGLETSGIFRIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRFLNHL 191
L Q GL G+FR+ GN K +++L+ F + G + V ASLL+ FL L
Sbjct: 79 LTQHGLTQEGLFRVNGNVKVVEQLRLKFES----GVPVELGKDGDVCSAASLLKLFLREL 134
Query: 192 QEPLIPLALYDSFRKPLIDRPRIIQHLKKASND 224
+ LI AL +PR IQ + ND
Sbjct: 135 PDSLITSAL----------QPRFIQLFQDGRND 157
>CE21517 [T] KOG4270 GTPase-activator protein
Length = 604
Score = 50.8 bits (120), Expect = 5e-06
Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 14/103 (13%)
Query: 93 VFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRI 152
VF VPL + LS+ RI V+ KC +L+Q G+ GIFR++GN +I
Sbjct: 238 VFGVPLDEHLSIQKE------------RISGVLTKCCDFLRQNGMNERGIFRVSGNASKI 285
Query: 153 KELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRFLNHLQEPL 195
K ++ + A +++ H VAS L+ +L L +PL
Sbjct: 286 KRIRAALDA-GQFDADEKHYNN-DPHAVASTLKAYLRELPDPL 326
>7298628 [T] KOG1449 Predicted Rho GTPase-activating protein CdGAPr
Length = 1817
Score = 50.4 bits (119), Expect = 7e-06
Identities = 38/124 (30%), Positives = 59/124 (46%), Gaps = 18/124 (14%)
Query: 83 LNQRHGFSGQVFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAKCGAYLKQQGLETSGI 142
L Q + +VFN LS+ L L+S IP+V+ C +++ G+ GI
Sbjct: 411 LKQSGIYRERVFNCDLSEHL------------LNSGQDIPMVLRSCAEFIENYGV-IDGI 457
Query: 143 FRIAGNTKRIKELQYIFSTP--PNYGAKFSNWDEFTVHDVASLLRRFLNHLQEPLIPLAL 200
+R++G T I+ L+ F P+ G D +H V+SLL+ + L PL L
Sbjct: 458 YRLSGITSNIQRLRRAFDEERVPDLGNPEMKQD---IHAVSSLLKMYFRELPNPLCTYQL 514
Query: 201 YDSF 204
YD+F
Sbjct: 515 YDNF 518
>Hs5803145 [T] KOG4370 Ral-GTPase effector RLIP76
Length = 655
Score = 50.1 bits (118), Expect = 9e-06
Identities = 29/114 (25%), Positives = 60/114 (52%), Gaps = 13/114 (11%)
Query: 93 VFNVPLSQSLSVASAEVIVQTELSSFGRIPIVVAKCGAYLKQQGLETSGIFRIAGNTKRI 152
+F +PL A+ + +T + R+P V +C Y+++ G++ GI+R++G ++
Sbjct: 189 IFGIPL--------ADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKV 240
Query: 153 KELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRFLNHLQEPLIPLALYDSFRK 206
EL+ + + +N +++ + VASLL+++L L E L+ L F +
Sbjct: 241 DELKAAYDREES-----TNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEE 289
>CE16171 [T] KOG4271 Rho-GTPase activating protein
Length = 1124
Score = 50.1 bits (118), Expect = 9e-06
Identities = 36/118 (30%), Positives = 57/118 (47%), Gaps = 6/118 (5%)
Query: 87 HGFSGQVFNVPLSQSLS--VASAEVIVQTELSSFGRIPIVVAKCGAYLKQQG-LETSGIF 143
H S + N P S S +A+ E + S +IPI + KC +++Q G E G++
Sbjct: 917 HDLSTSLINYPASTSTQGVIAANETLETLCSKSPSQIPIYLEKCIQFIEQNGGFEQEGLY 976
Query: 144 RIAGNTKRIKELQYIFSTPPNYGAKFSNWDEFTVHDVASLLRRFLNHLQEPLIPLALY 201
R+ GN + E++ F YG + + VH A+ L+ F + L E LIP A +
Sbjct: 977 RVPGNQTHLAEVEKRFL---KYGEFDVSSFDTPVHVAATALKSFFSCLPESLIPTAYH 1031
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.312 0.130 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,552,242
Number of Sequences: 60738
Number of extensions: 1356368
Number of successful extensions: 4158
Number of sequences better than 1.0e-05: 31
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 4102
Number of HSP's gapped (non-prelim): 57
length of query: 553
length of database: 30,389,216
effective HSP length: 111
effective length of query: 442
effective length of database: 23,647,298
effective search space: 10452105716
effective search space used: 10452105716
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)