ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV0822 good E KOG0785 Amino acid transport and metabolism Isocitrate dehydrogenase, alpha subunit
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV0822 288825 289928 368
(368 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR136w [E] KOG0785 Isocitrate dehydrogenase alpha subunit 578 e-165
SPBC902.05c [E] KOG0785 Isocitrate dehydrogenase alpha subunit 419 e-117
7293593 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 348 5e-96
Hs5031777 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 328 8e-90
CE10354 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 328 1e-89
At5g03290 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 311 7e-85
At3g09805 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 304 2e-82
YNL037c [E] KOG0784 Isocitrate dehydrogenase gamma subunit 262 7e-70
At4g35260 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 253 4e-67
At4g35650 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 250 3e-66
At2g17130 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 249 5e-66
SPAC11G7.03 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 244 1e-64
Hs4758582 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 229 5e-60
7300799 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 226 5e-59
7301367 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 223 5e-58
CE16887 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 218 9e-57
Hs5901982 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 218 1e-56
CE08620 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 212 6e-55
CE00970 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 204 2e-52
7291785 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 168 1e-41
SPAC31G5.04 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 163 3e-40
YIL094c [E] KOG0785 Isocitrate dehydrogenase alpha subunit 160 4e-39
At1g32480 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 127 3e-29
At1g80560 [E] KOG0786 3-isopropylmalate dehydrogenase 122 8e-28
At5g14200 [E] KOG0786 3-isopropylmalate dehydrogenase 117 2e-26
At1g31180 [E] KOG0786 3-isopropylmalate dehydrogenase 115 1e-25
YCL018w [E] KOG0786 3-isopropylmalate dehydrogenase 91 4e-18
SPBC1A4.02c [E] KOG0786 3-isopropylmalate dehydrogenase 76 7e-14
7302952 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 74 3e-13
>YOR136w [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 369
Score = 578 bits (1491), Expect = e-165
Identities = 291/359 (81%), Positives = 317/359 (88%)
Query: 10 SCRFLATKKQPSIGRYTGKPNPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWES 69
S RFLAT KQPSIGRYTGKPNP TGKYTVSFIEGDG+GPEISKSVK IFSAA VPIEWES
Sbjct: 11 SRRFLATVKQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWES 70
Query: 70 CDVSPIFVNGLTTIPDPAVASINKNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRP 129
CDVSPIFVNGLTTIPDPAV SI KNL+ALKGPLATPIGKGHRSLNLTLRKTFGLFANVRP
Sbjct: 71 CDVSPIFVNGLTTIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRP 130
Query: 130 AKSIEGYKTTYENVNLVLIRENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEY 189
AKSIEG+KTTYENV+LVLIRENTEGEYSGIEH+V PGVVQSIKLIT+DASERVIRYAFEY
Sbjct: 131 AKSIEGFKTTYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEY 190
Query: 190 ARAVDRSKVLVVHKSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAY 249
ARA+ R +V+VVHKSTIQRLADGLFV+VAK+LS EYPD+ L+TEL+DN+VLK V +P AY
Sbjct: 191 ARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAY 250
Query: 250 DDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHTVSIFEAVHGSAPDIAGQNKANP 309
D V VCPNLYGDI ANIGH +SIFEAVHGSAPDIAGQ+KANP
Sbjct: 251 TDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKISIFEAVHGSAPDIAGQDKANP 310
Query: 310 TALLLSSVMMLNHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
TALLLSSVMMLNHMGLT HAD+I+ AVL+TIAS +NRTGDL G+A+TSSFT+AVI+RL
Sbjct: 311 TALLLSSVMMLNHMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKRL 369
>SPBC902.05c [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 378
Score = 419 bits (1077), Expect = e-117
Identities = 220/359 (61%), Positives = 263/359 (72%), Gaps = 4/359 (1%)
Query: 10 SCRFLATKKQPSIGRYTGKPNPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWES 69
S RF +TK + G Y G N G YTV+ I GDG+GPEI++SV+ IF AAKVPIEWE
Sbjct: 23 SFRFSSTKA--AAGTYEGVKNAN-GNYTVTMIAGDGIGPEIAQSVERIFKAAKVPIEWER 79
Query: 70 CDVSPIFVNGLTTIPDPAVASINKNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRP 129
V PI NG TTIPD A S+ KN +ALKGPLATPIGKGH S+NLTLR+TFGLFANVRP
Sbjct: 80 VKVYPILKNGTTTIPDDAKESVRKNKVALKGPLATPIGKGHVSMNLTLRRTFGLFANVRP 139
Query: 130 AKSIEGYKTTYENVNLVLIRENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEY 189
SI GYKT Y+NVN VLIRENTEGEYSGIEH V PGVVQSIKLIT+ ASERVIRYAF+Y
Sbjct: 140 CVSITGYKTPYDNVNTVLIRENTEGEYSGIEHEVIPGVVQSIKLITRAASERVIRYAFQY 199
Query: 190 ARAVDRSKVLVVHKSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAY 249
AR ++ + VVHK+TI R+ADGLF++ AK+L+ EYPDIEL+ E+LDN LK V P Y
Sbjct: 200 ARQTGKNNITVVHKATIMRMADGLFLECAKELAPEYPDIELREEILDNACLKIVTDPVPY 259
Query: 250 DDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHTVSIFEAVHGSAPDIAGQNKANP 309
++ V+V PNLYGDI NIG+ SIFEAVHG+APDIAG+ ANP
Sbjct: 260 NNTVMVMPNLYGDI-VSDMCAGLIGGLGLTPSGNIGNQASIFEAVHGTAPDIAGKGLANP 318
Query: 310 TALLLSSVMMLNHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
TALLLSSVMML HM L ++A +IE A+ T+A++ RT DLGG ++ +TDA+I +L
Sbjct: 319 TALLLSSVMMLKHMNLNDYAKRIESAIFDTLANNPDARTKDLGGKSNNVQYTDAIISKL 377
>7293593 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 377
Score = 348 bits (894), Expect = 5e-96
Identities = 185/359 (51%), Positives = 245/359 (67%), Gaps = 9/359 (2%)
Query: 15 ATKKQPSIGRYTGKP----NPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESC 70
A P++ + P + +G V+ I GDG+GPEIS +V+ IF+AA VPIEWE+
Sbjct: 23 AVTATPAVSQVNATPAASRSYSSGTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAV 82
Query: 71 DVSPIF-VNGLTTIPDPAVASINKNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRP 129
DV+P+ +G IP A+ S+N N I LKGPL TP+GKGHRSLNL LRK F L+ANVRP
Sbjct: 83 DVTPVRGPDGKFGIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLALRKEFNLYANVRP 142
Query: 130 AKSIEGYKTTYENVNLVLIRENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEY 189
+S+EGYKT Y++V++V IRENTEGEYSGIEH + GVVQSIKLIT++AS+RV YAF+Y
Sbjct: 143 CRSLEGYKTLYDDVDVVTIRENTEGEYSGIEHEIVDGVVQSIKLITEEASKRVAEYAFQY 202
Query: 190 ARAVDRSKVLVVHKSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAY 249
A+ +R KV VVHK+ I R++DGLF+ + ++ ++P+I+ + + LD L VQ+P Y
Sbjct: 203 AKNNNRKKVTVVHKANIMRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKY 262
Query: 250 DDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHTVSIFEAVHGSAPDIAGQNKANP 309
D V+V PNLYGDI N+G ++FE+VHG+APDIAG++ ANP
Sbjct: 263 D--VLVMPNLYGDI-LSDMCAGLVGGLGLTPSGNMGLNGALFESVHGTAPDIAGKDLANP 319
Query: 310 TALLLSSVMMLNHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
TALLLS+VMML HM L +ADKIE+A TI + K TGDLGG A S FT+ + +L
Sbjct: 320 TALLLSAVMMLRHMELNTYADKIERAAFETI-KEGKYLTGDLGGRAKCSEFTNEICAKL 377
>Hs5031777 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 366
Score = 328 bits (841), Expect = 8e-90
Identities = 182/337 (54%), Positives = 225/337 (66%), Gaps = 6/337 (1%)
Query: 34 GKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIF-VNGLTTIPDPAVASIN 92
G TV+ I GDG+GPEIS +V IF AAK PI+WE +V+ I G IP A S++
Sbjct: 30 GVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMD 89
Query: 93 KNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENT 152
KN + LKGPL TPI GH S+NL LRKTF L+ANVRP SIEGYKT Y +VN+V IRENT
Sbjct: 90 KNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENT 149
Query: 153 EGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLADG 212
EGEYSGIEHV+ GVVQSIKLIT+ AS+R+ +AFEYAR RS V VHK+ I R++DG
Sbjct: 150 EGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDG 209
Query: 213 LFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXXX 272
LF+ ++++ DI+ LD L VQ P +D V+V PNLYGDI
Sbjct: 210 LFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFD--VLVMPNLYGDI-LSDLCAGL 266
Query: 273 XXXXXXXXXANIG-HTVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHADK 331
NIG + V+IFE+VHG+APDIAG++ ANPTALLLS+VMML HMGL +HA +
Sbjct: 267 IGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAR 326
Query: 332 IEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
IE A TI D K+ T DLGG+A S FT+ + R+
Sbjct: 327 IEAACFATI-KDGKSLTKDLGGNAKCSDFTEEICRRV 362
>CE10354 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 374
Score = 328 bits (840), Expect = 1e-89
Identities = 179/348 (51%), Positives = 228/348 (65%), Gaps = 21/348 (6%)
Query: 38 VSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFV-NGLTTIPDPAVASINKNLI 96
V+ I GDG+GPEIS SV+ IF AA PI W+ DV+P+ +G+ IP + ++ N +
Sbjct: 27 VTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPVKGRDGVFRIPSRCIELMHANKV 86
Query: 97 ALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENTEGEY 156
LKGPL TPIGKGHRSLNL +RK F L+ANVRP +S+EG+KT Y+NV++V IRENTEGEY
Sbjct: 87 GLKGPLETPIGKGHRSLNLAVRKEFSLYANVRPCRSLEGHKTLYDNVDVVTIRENTEGEY 146
Query: 157 SGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLADGLFVD 216
SGIEH + PGVVQSIKLIT+ AS V +AFEYAR R V VHK+ I R +DGLF+
Sbjct: 147 SGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTAVHKANIMRQSDGLFLS 206
Query: 217 VAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXXXXXXX 276
+ ++ ++ YPDI+ + LD L VQ P YD V+V PNLYGDI
Sbjct: 207 ICREQAALYPDIKFKEAYLDTVCLNMVQDPSQYD--VLVMPNLYGDI-LSDLCAGLVGGL 263
Query: 277 XXXXXANIGHTVSIFE----------------AVHGSAPDIAGQNKANPTALLLSSVMML 320
NIG ++F+ +VHG+APDIAGQ+KANPTALLLS+VMML
Sbjct: 264 GVTPSGNIGKGAAVFDEIQFFIQTKLTKFLYRSVHGTAPDIAGQDKANPTALLLSAVMML 323
Query: 321 NHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
+M L +HA +IEKAV IA D + +TGDLGG+ + SSFT V R+
Sbjct: 324 RYMNLPQHAARIEKAVFDAIA-DGRAKTGDLGGTGTCSSFTADVCARV 370
>At5g03290 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 372
Score = 311 bits (798), Expect = 7e-85
Identities = 167/341 (48%), Positives = 227/341 (65%), Gaps = 12/341 (3%)
Query: 33 TGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWES----CDVSPIFVNGLTTIPDPAV 88
T T + GDG+GPEI++SVK +F+ A VPIEWE ++ P + LT ++
Sbjct: 39 TTPITATLFPGDGIGPEIAESVKKVFTTAGVPIEWEEHYVGTEIDPRTQSFLTW---ESL 95
Query: 89 ASINKNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLI 148
S+ +N + LKGP+ATPIGKGHRSLNLTLRK L+ANVRP S+ GYKT Y++V+L+ I
Sbjct: 96 ESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITI 155
Query: 149 RENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQR 208
RENTEGEYSG+EH V GVV+S+K+IT+ AS RV YAF YA+ R +V +HK+ I +
Sbjct: 156 RENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFLYAKTHGRERVSAIHKANIMQ 215
Query: 209 LADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXX 268
DGLF+ ++++ +YP+I + ++DN + V++P +D V+V PNLYGDI
Sbjct: 216 KTDGLFLKCCREVAEKYPEITYEEVVIDNCCMMLVKNPALFD--VLVMPNLYGDI-ISDL 272
Query: 269 XXXXXXXXXXXXXANIGHT-VSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTE 327
NIG V++ EAVHGSAPDIAG+N ANPTALLLS VMML H+ E
Sbjct: 273 CAGLVGGLGLTPSCNIGEDGVALAEAVHGSAPDIAGKNLANPTALLLSGVMMLRHLKFNE 332
Query: 328 HADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
A++I A++ TIA + K RT DLGGS++T+ FT A+ + L
Sbjct: 333 QAEQIHSAIINTIA-EGKYRTADLGGSSTTTEFTKAICDHL 372
>At3g09805 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 374
Score = 304 bits (778), Expect = 2e-82
Identities = 165/331 (49%), Positives = 223/331 (66%), Gaps = 12/331 (3%)
Query: 43 GDGVGPEISKSVKAIFSAAKVPIEWES----CDVSPIFVNGLTTIPDPAVASINKNLIAL 98
GDG+GPEI++SVK +F+AA V I+W+ +V P + LT + S+ KN + L
Sbjct: 51 GDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTW---DNLQSVLKNKVGL 107
Query: 99 KGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENTEGEYSG 158
KGP+ATPIGKGHRSLNLTLRK L+ANVRP S+ GYKT Y++V+L+ IRENTEGEYSG
Sbjct: 108 KGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSG 167
Query: 159 IEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLADGLFVDVA 218
+EH V GVV+S+K+IT+ AS RV YAF YA+ R KV +HK+ I + DGLF+
Sbjct: 168 LEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCC 227
Query: 219 KKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXXXXXXXXX 278
+++++YP+I + ++DN + V++P +D V+V PNLYGDI
Sbjct: 228 DEVAAKYPEIYYEKVVIDNCCMMLVKNPALFD--VLVMPNLYGDI-ISDLCAGLVGGLGL 284
Query: 279 XXXANIGHT-VSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHADKIEKAVL 337
NIG +++ EAVHGSAPDIAG N ANPTALLLS VMML H+ L + A++I A++
Sbjct: 285 TPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAII 344
Query: 338 TTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
TIA + K RT DLGGS++T+ FT A+ + L
Sbjct: 345 NTIA-EGKYRTADLGGSSTTTDFTKAICDHL 374
>YNL037c [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 360
Score = 262 bits (669), Expect = 7e-70
Identities = 146/344 (42%), Positives = 217/344 (62%), Gaps = 12/344 (3%)
Query: 29 PNPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPI-FVNGLTTIPDPA 87
P G++TV+ I GDGVG EI+ SV+ IF A +PI+WE+ ++ G+ A
Sbjct: 22 PKKYGGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVYE----A 77
Query: 88 VASINKNLIALKGPLATPIGK-GHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLV 146
V S+ +N I LKG TP + GH SLN+ LRK ++ANV KS++G KT +++L+
Sbjct: 78 VESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLI 137
Query: 147 LIRENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTI 206
+IRENTEGE+SG+EH PGVV+S+K++T+ +ER+ R+AF++A+ +R V VHK+ I
Sbjct: 138 VIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANI 197
Query: 207 QRLADGLFVDVAKKL-SSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXX 265
+L DGLF ++ ++ EYPDI++ + ++DN ++ V P +D V+V P++YG I
Sbjct: 198 MKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD--VLVTPSMYGTI-L 254
Query: 266 XXXXXXXXXXXXXXXXANIGHTVSIFE-AVHGSAPDIAGQNKANPTALLLSSVMMLNHMG 324
AN G ++FE DI GQN ANPTA++LSS +MLNH+G
Sbjct: 255 GNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLG 314
Query: 325 LTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
L E+A +I KAV TIA + K+ T D+GGS+ST+ FT+ +I +L
Sbjct: 315 LNEYATRISKAVHETIA-EGKHTTRDIGGSSSTTDFTNEIINKL 357
>At4g35260 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 367
Score = 253 bits (645), Expect = 4e-67
Identities = 146/348 (41%), Positives = 208/348 (58%), Gaps = 13/348 (3%)
Query: 26 TGKPNPKTGK-YTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIP 84
T P P G V+ I GDG+GP ++ +V+ + A PI +E DV ++ +P
Sbjct: 27 TYMPRPGDGAPRAVTLIPGDGIGPLVTNAVEQVMEAMHAPIFFEKYDVH----GEMSRVP 82
Query: 85 DPAVASINKNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVN 144
+ SI KN + LKG L TP+G G SLN+ LRK LFA++ ++ G T +ENV+
Sbjct: 83 PEVMESIRKNKVCLKGGLKTPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVD 142
Query: 145 LVLIRENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKS 204
+V+IRENTEGEY+G+EH V PGVV+S+K+IT+ SER+ +YAFEYA +R KV VHK+
Sbjct: 143 IVVIRENTEGEYAGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKA 202
Query: 205 TIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIX 264
I +LADGLF++ ++++ +YP I ++DN ++ V PE +D V+V PNLYG++
Sbjct: 203 NIMKLADGLFLESCREVAKKYPSITYNEIIVDNCCMQLVAKPEQFD--VMVTPNLYGNL- 259
Query: 265 XXXXXXXXXXXXXXXXXANIGHTVSIFE----AVHGSAPDIAGQNKANPTALLLSSVMML 320
N+G ++FE A + I +NKANP ALLLSS MML
Sbjct: 260 VANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVGKDKIVLENKANPVALLLSSAMML 319
Query: 321 NHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
H+ AD++E AV IA + K RT DLGG+++T DAVI +L
Sbjct: 320 RHLQFPSFADRLETAVKKVIA-EGKCRTKDLGGTSTTQEVVDAVIAKL 366
>At4g35650 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 368
Score = 250 bits (638), Expect = 3e-66
Identities = 149/365 (40%), Positives = 211/365 (56%), Gaps = 16/365 (4%)
Query: 12 RFLATKKQP--SIGR-YTGKPNPKTGK-YTVSFIEGDGVGPEISKSVKAIFSAAKVPIEW 67
R LA P S+ R T P P G TV+ I GDG+GP ++ +V+ + A P+ +
Sbjct: 11 RLLANPPSPFTSLSRSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHF 70
Query: 68 ESCDVSPIFVNGLTTIPDPAVASINKNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANV 127
E +V + + +P+ + S+ +N + LKG LATP+G G SLN+ LRK +FA++
Sbjct: 71 ERYEV----LGNMRKVPEEVIESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASL 126
Query: 128 RPAKSIEGYKTTYENVNLVLIRENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAF 187
++ G T +ENV++V+IRENTEGEYSG+EH V PGVV+S+K+IT+ SER+ RYAF
Sbjct: 127 VNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAF 186
Query: 188 EYARAVDRSKVLVVHKSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPE 247
EYA +R KV VHK+ I +LADGLF++ ++++ Y I ++DN ++ V PE
Sbjct: 187 EYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPE 246
Query: 248 AYDDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHTVSIFE----AVHGSAPDIAG 303
+D V+V PNLYG++ N+G +IFE A + +
Sbjct: 247 QFD--VMVTPNLYGNL-IANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVE 303
Query: 304 QNKANPTALLLSSVMMLNHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDA 363
Q KANP ALLLSS MML H+ AD++E AV I + K RT DLGG +T DA
Sbjct: 304 QKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVI-KEGKYRTKDLGGDCTTQEVVDA 362
Query: 364 VIERL 368
VI L
Sbjct: 363 VIAAL 367
>At2g17130 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 367
Score = 249 bits (636), Expect = 5e-66
Identities = 151/377 (40%), Positives = 221/377 (58%), Gaps = 20/377 (5%)
Query: 1 MFRQSI-VKQSCRFLATKKQPSIGRYTGKPNPKTGK-YTVSFIEGDGVGPEISKSVKAIF 58
M RQS + ++ R +A+ + T P P GK V+ I GDGVGP ++ +V+ +
Sbjct: 1 MSRQSFSLLKNLRSIASGSKIQTRSVTYMPRPGDGKPRPVTLIPGDGVGPLVTNAVQQVM 60
Query: 59 SAAKVPIEWESCDVSPIFVNG-LTTIPDPAVASINKNLIALKGPLATPIGKGHRSLNLTL 117
A P+ +E P V+G + ++P+ + SI KN + LKG L TP+G G SLN+ L
Sbjct: 61 EAMHAPVYFE-----PFEVHGDMKSLPEGLLESIKKNKVCLKGGLKTPVGGGVSSLNVNL 115
Query: 118 RKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENTEGEYSGIEHVVAPGVVQSIKLITQD 177
RK LFA++ ++ G + +ENV++V+IRENTEGEY+G+EH V PGVV+S+K+IT+
Sbjct: 116 RKELDLFASLVNCFNLPGLASRHENVDIVVIRENTEGEYAGLEHEVVPGVVESLKVITKF 175
Query: 178 ASERVIRYAFEYARAVDRSKVLVVHKSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDN 237
SER+ +YAFEYA +R KV VHK+ I +LADGLF++ ++++ +YP I ++DN
Sbjct: 176 CSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCQEVAKKYPSIAYNEIIVDN 235
Query: 238 TVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHTVSIFEAVHGS 297
++ V PE +D V+V PNLYG++ N+G ++FE G+
Sbjct: 236 CCMQLVARPEQFD--VMVTPNLYGNL-VANTAAGIAGGTGVMPGGNVGAEYAVFE--QGA 290
Query: 298 APDIAG------QNKANPTALLLSSVMMLNHMGLTEHADKIEKAVLTTIASDAKNRTGDL 351
+ G Q ANP ALLLSS MML H+ AD++E AV IA + RT DL
Sbjct: 291 SAGNVGKDTTEEQKNANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIA-EGNCRTEDL 349
Query: 352 GGSASTSSFTDAVIERL 368
GG+++T DAVI L
Sbjct: 350 GGNSTTQEVVDAVIANL 366
>SPAC11G7.03 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 356
Score = 244 bits (624), Expect = 1e-64
Identities = 140/339 (41%), Positives = 203/339 (59%), Gaps = 8/339 (2%)
Query: 34 GKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTT--IPDPAVASI 91
GKYTV+ I GDG+G E S +V IF A VPIE+E DV+ + N ++ A+ S+
Sbjct: 19 GKYTVTLIPGDGIGRETSNAVTEIFKTANVPIEFEEIDVTGMEKNNKSSGDALHEAIQSL 78
Query: 92 NKNLIALKGPLATPIGKG-HRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRE 150
+N + LKG L TP KG H S N+ LRK ++A++ K+I G+KT ++NV+ +IRE
Sbjct: 79 KRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKTRHDNVDFAIIRE 138
Query: 151 NTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLA 210
NTEGEYSG+EH PGVV+S+K+IT+ S+R+ ++AF++A R V +HK+ I +LA
Sbjct: 139 NTEGEYSGLEHQSVPGVVESLKIITEYKSKRIAQFAFDFALQNGRKSVTCIHKANIMKLA 198
Query: 211 DGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXX 270
DGLF +++ Y I + ++DN ++ V P+ +D V+V PNLYG I
Sbjct: 199 DGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFD--VLVMPNLYGSI-LSNIGS 255
Query: 271 XXXXXXXXXXXANIGHTVSIFE-AVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHA 329
AN G ++FE I G+ +ANPTA +LS+ +ML H+GL ++A
Sbjct: 256 ALVGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPTAAILSACLMLRHLGLKDYA 315
Query: 330 DKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
D I A + I + K T DLGGSAST FT A++ER+
Sbjct: 316 DLINAATYSVI-EEGKTLTKDLGGSASTGDFTHAILERM 353
>Hs4758582 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 393
Score = 229 bits (584), Expect = 5e-60
Identities = 131/338 (38%), Positives = 200/338 (58%), Gaps = 10/338 (2%)
Query: 34 GKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIPDPAVASINK 93
G++TV+ I GDG+GPE+ VK++F A VP+++E VS N A+ +I +
Sbjct: 53 GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSS---NADEEDIRNAIMAIRR 109
Query: 94 NLIALKGPLATP--IGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIREN 151
N +ALKG + T + H+S N LR + L+ANV KS+ G T +++++++++REN
Sbjct: 110 NRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVREN 169
Query: 152 TEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLAD 211
TEGEYS +EH GVV+S+K+IT+ S R+ YAF+ A+ R KV VHK+ I +L D
Sbjct: 170 TEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGD 229
Query: 212 GLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXX 271
GLF+ +++++ YP I + ++DNT ++ V P+ +D V+V PNLYG+I
Sbjct: 230 GLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFD--VMVMPNLYGNI-VNNVCAG 286
Query: 272 XXXXXXXXXXANIGHTVSIFE-AVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHAD 330
AN GH ++FE A + IA +N ANPTA LL+S MML+H+ L +A
Sbjct: 287 LVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYAT 346
Query: 331 KIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
I KAVL ++ ++ T D+GG +TS VI +
Sbjct: 347 SIRKAVLASMDNE-NMHTPDIGGQGTTSEAIQDVIRHI 383
>7300799 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 370
Score = 226 bits (575), Expect = 5e-59
Identities = 128/343 (37%), Positives = 197/343 (57%), Gaps = 15/343 (4%)
Query: 30 NPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWES---CDVSPIFVNGLTTIPDP 86
N + T + I GDGVGPE+ S++ +F AA VP+++E +++P+ L+ +
Sbjct: 32 NYGANRTTCTLIPGDGVGPELVYSLQEVFKAASVPVDFECYFLSEINPV----LSAKLED 87
Query: 87 AVASINKNLIALKGPLATP----IGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYEN 142
VASI KN + +KG LATP +G ++LN+ LR L+ANV +S+ G KT + N
Sbjct: 88 VVASIQKNKVCIKGVLATPDYSNVGD-LQTLNMKLRNDLDLYANVVHVRSLPGVKTRHTN 146
Query: 143 VNLVLIRENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVH 202
++ V+IRE TEGEYS +EH PG+V+ +K+IT S R+ ++AF+YA R KV VH
Sbjct: 147 IDTVIIREQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYATKNQRKKVTAVH 206
Query: 203 KSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGD 262
K+ I +L DGLF+ +++S YP I+ + ++DNT ++ V +P +D V+V PNLYG
Sbjct: 207 KANIMKLGDGLFLRSCEEVSRLYPRIQFEKMIVDNTTMQMVSNPNQFD--VMVTPNLYGA 264
Query: 263 IXXXXXXXXXXXXXXXXXXANIGHTVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNH 322
I + +V + + G+N ANPTA+LL V +L H
Sbjct: 265 IVDNLASGLVGGAGVVAGASYSSESVVFEPGARHTFAEAVGKNVANPTAMLLCGVKLLRH 324
Query: 323 MGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVI 365
+ L + + I+ A+ + +D K RT DLGG ++T FT A+I
Sbjct: 325 INLPTYGEIIQNAI-NKVLNDGKVRTKDLGGQSTTQDFTRAII 366
>7301367 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 393
Score = 223 bits (567), Expect = 5e-58
Identities = 132/368 (35%), Positives = 211/368 (56%), Gaps = 11/368 (2%)
Query: 6 IVKQSCRFLATKKQPSIGRYTGKPNPKT---GKYTVSFIEGDGVGPEISKSVKAIFSAAK 62
+ K+ +A K + TG P G++ V+ + G G+GPE+ V+ IF
Sbjct: 25 VTKEKTEDVAHTKSALQKKVTGTDIPSAQYGGRHAVTMLPGGGIGPELMGYVREIFRYCG 84
Query: 63 VPIEWESCDVSPIFVNGLTTIPDPAVASINKNLIALKGPLATPIGK-GHRSLNLTLRKTF 121
PI++E D+ P G + D A+ SI +N +ALKG + T S N+ +R
Sbjct: 85 APIDFEVIDIDPS-TEGNDDL-DYAITSIKRNGVALKGNIETKSQSLTEVSRNVAIRNEL 142
Query: 122 GLFANVRPAKSIEGYKTTYENVNLVLIRENTEGEYSGIEHVVAPGVVQSIKLITQDASER 181
L+ NV KS G + ++++VLIR+NT+GEY+ +EH PG+V+S+K++T + +ER
Sbjct: 143 DLYVNVVHCKSYPGIPARHHDIDVVLIRQNTDGEYAMLEHESVPGIVESMKVVTVENAER 202
Query: 182 VIRYAFEYARAVDRSKVLVVHKSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLK 241
V RYAFE+AR +R KV +HK+ I +L+DGLF++VA ++ +YP++E ++DNT ++
Sbjct: 203 VARYAFEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYPELEHNNMIIDNTCMQ 262
Query: 242 TVQHPEAYDDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHTVSIFE-AVHGSAPD 300
+V +P +D V+ NLYG I N G +IFE +
Sbjct: 263 SVSNPHQFD--VMNMTNLYGTI-VSNVLCGLMGGAGLISGRNYGDHYAIFEPGTRNTGTA 319
Query: 301 IAGQNKANPTALLLSSVMMLNHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSF 360
IAG+N ANP A++ +S+ MLNH+G EHA+ I++AV TI +DA RT D+GG+ S++
Sbjct: 320 IAGKNIANPVAMISASIDMLNHLGHKEHANVIQEAVYQTIVNDA-IRTPDIGGTNSSTDV 378
Query: 361 TDAVIERL 368
+ +++ L
Sbjct: 379 VENILKIL 386
>CE16887 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 373
Score = 218 bits (556), Expect = 9e-57
Identities = 123/337 (36%), Positives = 195/337 (57%), Gaps = 9/337 (2%)
Query: 34 GKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIPDPAVASINK 93
G++TV + GDG+GPE+ ++ IFS P+ +E VS ++G D A+ +I +
Sbjct: 34 GRHTVCALPGDGIGPEMIAHIRNIFSFCHAPVNFEEVQVSSSLLDGDM---DAAMLAIER 90
Query: 94 NLIALKGPLATPIGKGH-RSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENT 152
N +A+KG + T S N+ LR L+AN+ +I T + +++VLIRENT
Sbjct: 91 NGVAIKGNIETKHDDPQFNSRNVELRTKLDLYANILHCVTIPTVPTRHSGIDIVLIRENT 150
Query: 153 EGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLADG 212
EGEYSG+EH PG+V+SIK++T++ ER+ R AFEYA+A R KV VHK+ IQ+L DG
Sbjct: 151 EGEYSGLEHEAVPGIVESIKIVTREKIERISRMAFEYAKANGRKKVTAVHKANIQKLGDG 210
Query: 213 LFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXXX 272
LF+ V + +S +Y DI+ + ++DN ++ V P+ +D V+V PNLYG+I
Sbjct: 211 LFLKVVRDMSEDYKDIKFEAMIVDNASMQLVSKPQQFD--VMVMPNLYGNI-ISNIACGL 267
Query: 273 XXXXXXXXXANIGHTVSIFE-AVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHADK 331
N+G ++FE + +AG++ ANPTA + +SV ML ++G HA+
Sbjct: 268 VGGPGLVSGMNLGDKYAVFETGTRNTGTSLAGKDIANPTAFIRASVDMLRYLGCHYHANI 327
Query: 332 IEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
I A+ + + + T D+GG+ S S +A ++ +
Sbjct: 328 ISDALWKALV-EQRIHTADIGGNNSASDVINATLQNI 363
>Hs5901982 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 385
Score = 218 bits (555), Expect = 1e-56
Identities = 129/339 (38%), Positives = 200/339 (58%), Gaps = 9/339 (2%)
Query: 34 GKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIPDPAVASINK 93
G + V+ + GDGVGPE+ +VK +F AA VP+E++ +S + + ++S+ +
Sbjct: 47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
Query: 94 NLIALKGPLATPIG-KGH-RSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIREN 151
N +A+ G + TP+ KG S ++ LR+ LFANV KS+ GY T + N++LV+IRE
Sbjct: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
Query: 152 TEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLAD 211
TEGEYS +EH A GV++ +K++T+ S+R+ ++AF+YA R KV VHK+ I +L D
Sbjct: 167 TEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGD 226
Query: 212 GLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXX 271
GLF+ ++++ YP I+ +T ++DN ++ VQ+P +D V+V PNLYG+I
Sbjct: 227 GLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFD--VLVMPNLYGNI-IDNLAAG 283
Query: 272 XXXXXXXXXXANIGHTVSIFE--AVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHA 329
+ ++FE A H A + G+N ANPTA+LLS+ ML H+ L H+
Sbjct: 284 LVGGAGVVPGESYSAEYAVFETGARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHS 342
Query: 330 DKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
I AV I K RT D+GG ++T+ F +VI L
Sbjct: 343 SMIADAVKKVI-KVGKVRTRDMGGYSTTTDFIKSVIGHL 380
>CE08620 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 379
Score = 212 bits (540), Expect = 6e-55
Identities = 128/346 (36%), Positives = 202/346 (57%), Gaps = 12/346 (3%)
Query: 29 PNPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIPDPAV 88
P K V+ I GDGVGPE+ +V+ I +PIE+E +S + ++I + AV
Sbjct: 36 PTELNQKLKVTIIPGDGVGPELIYTVQDIVKQTGIPIEFEEIFLSEVHYTRSSSIEN-AV 94
Query: 89 ASINKNL-IALKGPL---ATPIGKGH-RSLNLTLRKTFGLFANVRPAKSIEGYKTTY-EN 142
SI +N +ALKG + A +G + LN+ LR++ LFANV K+++G KT + +
Sbjct: 95 ESIGRNNNVALKGAIEESAVLHTEGELQGLNMRLRRSLDLFANVVHIKTLDGIKTRHGKQ 154
Query: 143 VNLVLIRENTEGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVH 202
++ V++RE TEGEYS +EH + PGV++ +K+ T+ +ER+ ++AF+YA R KV VH
Sbjct: 155 LDFVIVREQTEGEYSSLEHELVPGVIECLKISTRTKAERIAKFAFDYATKTGRKKVTAVH 214
Query: 203 KSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGD 262
K+ I +L DGLF+ + ++ +YP I+ ++ ++DNT ++ V PE +D V+V PNLYG+
Sbjct: 215 KANIMKLGDGLFLRTCEGVAKQYPKIQFESMIIDNTCMQLVSKPEQFD--VMVMPNLYGN 272
Query: 263 IXXXXXXXXXXXXXXXXXXANIGHTVSIFE-AVHGSAPDIAGQNKANPTALLLSSVMMLN 321
I ++G IFE S + G++ ANPTA++L + MLN
Sbjct: 273 I-IDNLAAGLVGGAGVVPGQSVGRDFVIFEPGSRHSFQEAMGRSIANPTAMILCAANMLN 331
Query: 322 HMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVIER 367
H+ L + + +AV + + K RT DLGG A+T F DAVI++
Sbjct: 332 HLHLDAWGNSLRQAV-ADVVKEGKVRTRDLGGYATTVDFADAVIDK 376
>CE00970 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 380
Score = 204 bits (519), Expect = 2e-52
Identities = 125/351 (35%), Positives = 197/351 (55%), Gaps = 25/351 (7%)
Query: 18 KQPSIGRYTGKPNPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFV 77
+ P + T K G++ V+ + GDG+GPE+ V+ I SA + P+++E V
Sbjct: 34 RSPVLQTNTTKLARYGGRHNVTVLPGDGIGPEMLHHVERILSAVQAPVDFE--------V 85
Query: 78 NGLTTIPDP------AVASINKNLIALKGPLATPIGK-GHRSLNLTLRKTFGLFANVRPA 130
LT+ D A+ +I +N +ALKG + T S NL LR+ L+ANV
Sbjct: 86 VNLTSKEDASEDLAEAITAIKRNGVALKGNIETKFDNPSFVSRNLELRRQLNLYANVLHC 145
Query: 131 KSIEGYKTTYENVNLVLIRENTEGEYSGIEHVVA----PGVVQSIKLITQDASERVIRYA 186
+I + + +++V+IRENTEGEYSG EH P VV+S+K++T++ SE++ R+A
Sbjct: 146 STIPTVPSRHTGIDMVIIRENTEGEYSGNEHEAVNAPHPRVVESLKVVTREKSEQITRFA 205
Query: 187 FEYARAVDRSKVLVVHKSTIQRLADGLFVDVAKKLS-SEYPDIELQTELLDNTVLKTVQH 245
F++A+ R KV VHK+ IQ+L DGLF+ VA ++ +EYPDIE ++DN ++ V
Sbjct: 206 FQFAKKYGRKKVTAVHKANIQKLGDGLFLKVATDIAKAEYPDIEFNAMIVDNASMQLVSR 265
Query: 246 PEAYDDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHTVSIFE-AVHGSAPDIAGQ 304
P+ +D V++ PNLYG+I NIG ++FE + +AG+
Sbjct: 266 PQQFD--VMLMPNLYGNI-ISNIACGLVGGPGLVSGMNIGEDYAVFETGTRNTGTTLAGK 322
Query: 305 NKANPTALLLSSVMMLNHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSA 355
+ ANPTA + ++V ML +GL HAD I ++ T+ D + T D+GG++
Sbjct: 323 DLANPTAFIRAAVDMLRFLGLQSHADMISDSLFRTLV-DKRIHTADIGGTS 372
>7291785 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 391
Score = 168 bits (425), Expect = 1e-41
Identities = 103/332 (31%), Positives = 171/332 (51%), Gaps = 13/332 (3%)
Query: 38 VSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIPDPAVASINKNLIA 97
V+ I G+GVG E+ +V+ + A K PIEW+ D + + S+ N +
Sbjct: 72 VTLINGEGVGRELMDAVQEVICAVKAPIEWDVHD--EFKAKDSDDVSPEVLKSLRANKVG 129
Query: 98 LKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENTEGEYS 157
+KGP+ + R +RK F FA V IEG + Y + ++V+IR+ EG+YS
Sbjct: 130 IKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYGDFDVVIIRDQMEGDYS 183
Query: 158 GIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLADGLFVDV 217
GIEH+V PGV+Q+IK+ T + R+ + F YA R ++ V HK+ I R+ DG F++
Sbjct: 184 GIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFLEA 243
Query: 218 AKKLSSEY-PDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXXXXXXX 276
+ + ++ D+ + LD +LK + P D V+V ++YGD+
Sbjct: 244 MRAEADKHVDDVLFEERYLDTCILKILLKPHKCD--VMVSSSMYGDVLRVIAGGMMGVPG 301
Query: 277 XXXXXANIGHTVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHADKIEKAV 336
++ ++F+ + +AG++ ANPT LLS+ +ML H+ + + AD+++ A+
Sbjct: 302 ICPGY-SVSSLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAI 360
Query: 337 LTTIASDAKNRTGDLGGSASTSSFTDAVIERL 368
+ D RT D+GG A S F AV + L
Sbjct: 361 -RKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 391
>SPAC31G5.04 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 362
Score = 163 bits (413), Expect = 3e-40
Identities = 120/363 (33%), Positives = 186/363 (51%), Gaps = 33/363 (9%)
Query: 33 TGKYTVSFIEGDGVGPEISKSVKAIFS--AAKVPIEWESCDVSP---IFVNGLTTIPDPA 87
T + + I DG+G E+ + + + AK ++++ D+ F +P+
Sbjct: 4 TRRIVLGLIPADGIGKEVVPAARRLMENLPAKHKLKFDFIDLDAGWGTFERTGKALPERT 63
Query: 88 VASINKNL-IALKGPLATPIGK--GHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVN 144
V + AL G + +P K G+ S + LRK GL+ANVRP KS++G K + V+
Sbjct: 64 VERLKTECNAALFGAVQSPTHKVAGYSSPIVALRKKMGLYANVRPVKSLDGAKG--KPVD 121
Query: 145 LVLIRENTEGEYSGIEHVV--APG--VVQSIKLITQDASERVIRYAFEYARAVDRSK--- 197
LV++RENTE Y E +V PG V ++I+ I+++AS ++ + AFE A++ + +
Sbjct: 122 LVIVRENTECLYVKEERMVQNTPGKRVAEAIRRISEEASTKIGKMAFEIAKSRQKIRESG 181
Query: 198 ---------VLVVHKSTIQRLADGLFVDV---AKKLSSEYPDIELQTELLDNTVLKTVQH 245
V ++HKS + + DGLF + A+ L Y I + +++D+ V + +
Sbjct: 182 TYSIHKKPLVTIIHKSNVMSVTDGLFRESCRHAQSLDPSYASINVDEQIVDSMVYRLFRE 241
Query: 246 PEAYDDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHTVSIFEAVHGSAPDIAGQN 305
PE +D VVV PNLYGDI AN+G + E VHGSAPDIAG+
Sbjct: 242 PECFD--VVVAPNLYGDILSDGAASLIGSLGLVPS-ANVGDNFVMSEPVHGSAPDIAGRG 298
Query: 306 KANPTALLLSSVMMLNHMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAVI 365
ANP A S +ML MG + A I AV + ++ K T DLGG + T+ TDAV+
Sbjct: 299 IANPVATFRSVALMLEFMGHQDAAADIYTAV-DKVLTEGKVLTPDLGGKSGTNEITDAVL 357
Query: 366 ERL 368
+
Sbjct: 358 ANI 360
>YIL094c [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 371
Score = 160 bits (404), Expect = 4e-39
Identities = 128/390 (32%), Positives = 192/390 (48%), Gaps = 41/390 (10%)
Query: 1 MFRQSIVKQS-CRFLATKKQPSIGRYTGKPNPKTGKYTVSFIEGDGVGPEISKSVKAIFS 59
MFR + S CR LA+ N T+ I GDG+G E+ + K +
Sbjct: 1 MFRSVATRLSACRGLAS-------------NAARKSLTIGLIPGDGIGKEVIPAGKQVLE 47
Query: 60 A--AKVPIEWESCDVSPIFVNGLTT---IPDPAVASINKNLI-ALKGPLATPIGK--GHR 111
+K + + D+ F T +PD V + + AL G + +P K G+
Sbjct: 48 NLNSKHGLSFNFIDLYAGFQTFQETGKALPDETVKVLKEQCQGALFGAVQSPTTKVEGYS 107
Query: 112 SLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENTEGEYSGIEHVV---APG-- 166
S + LR+ GLFANVRP KS+EG K + +++V++RENTE Y IE A G
Sbjct: 108 SPIVALRREMGLFANVRPVKSVEGEKG--KPIDMVIVRENTEDLYIKIEKTYIDKATGTR 165
Query: 167 VVQSIKLITQDASERVIRYAFEYA----RAVDRSKVLVVHKSTIQRLADGLFVDVAKKL- 221
V + K I++ A+ R+ A + A + ++ + V HKS + +DGLF ++ K++
Sbjct: 166 VADATKRISEIATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVY 225
Query: 222 ---SSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXXXXXXXXX 278
+Y I+ +++D+ V + + P+ +D V+V PNLYGDI
Sbjct: 226 ESNKDKYGQIKYNEQIVDSMVYRLFREPQCFD--VIVAPNLYGDILSDGAAALVGSLGVV 283
Query: 279 XXXANIGHTVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHADKIEKAVLT 338
AN+G + I E HGSAPDIAG+ ANP A + S+ +ML +G E A I KAV
Sbjct: 284 PS-ANVGPEIVIGEPCHGSAPDIAGKGIANPIATIRSTALMLEFLGHNEAAQDIYKAVDA 342
Query: 339 TIASDAKNRTGDLGGSASTSSFTDAVIERL 368
+ + +T DLGG AST D V+ RL
Sbjct: 343 NL-REGSIKTPDLGGKASTQQVVDDVLSRL 371
>At1g32480 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 294
Score = 127 bits (318), Expect = 3e-29
Identities = 98/326 (30%), Positives = 159/326 (48%), Gaps = 43/326 (13%)
Query: 46 VGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIPDPAVASINKNLIALKGPLATP 105
+ ++ +V + A + P+ +E+ + +N LT V SI KN + L G +
Sbjct: 8 IDSNVTNAVHQVMDAMQAPVYFETYIIKGKNMNHLTW---EVVDSIRKNKVCLNGRVNNS 64
Query: 106 IGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENTEGEYSGIEHVVAP 165
+ G RK LFA++ ++ G + +ENV++V+IRENTEGEY+G EH V P
Sbjct: 65 LCGG-------ARKELDLFASLVDCFNLNGQPSRHENVDIVVIRENTEGEYAGREHEVVP 117
Query: 166 GVVQSIKL-ITQDASERVIRYAFEYARAVDRSKVLVVHKS-TIQRLADGLFVDVAKKLSS 223
GV++S ++ +T+ S+R+ +YAFEYA R KV VH + ++LAD F++ ++++
Sbjct: 118 GVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAK 177
Query: 224 EYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXAN 283
YP+I + + + ++ + + N+ + +
Sbjct: 178 MYPNITYNE--IASRETRAIRRHSNSKSLWAIIANIASGV----------------AGGS 219
Query: 284 IGHTVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGLTEHADKIEKAVLTTIASD 343
G +IFE V GS N NP ALL SSVMML H+ L AD+++ AV I+
Sbjct: 220 FGDDYAIFEQV-GSV-----GNHKNPVALLFSSVMMLRHLLLPLFADRLKTAVTRVISE- 272
Query: 344 AKNRTGDLGGS-ASTSSFTDAVIERL 368
G G S +T D+VI L
Sbjct: 273 -----GKCGNSNTTTQEVVDSVIANL 293
>At1g80560 [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 405
Score = 122 bits (306), Expect = 8e-28
Identities = 108/383 (28%), Positives = 179/383 (46%), Gaps = 56/383 (14%)
Query: 7 VKQSCRFLATKKQPSIGRYTGK---PNPKTGKYTVSFIEGDGVGPEISKSVKAI------ 57
VK F A KQ S+ + + +P +YT++ + GDG+GPE+ K +
Sbjct: 12 VKVPATFRAVSKQ-SLAPFRVRCAVASPGKKRYTITLLPGDGIGPEVVSIAKNVLQQAGS 70
Query: 58 -----FSAAKVPIEWESCDVSPIFVNGLTTIPDPAVASINKNLIALKGPLATPIGKGHRS 112
F+ ++PI + D+ + +P+ +++ ++ L G + G++
Sbjct: 71 LEGVEFNFREMPIGGAALDLVGV------PLPEETISAAKESDAVLLGAIG-----GYKW 119
Query: 113 LN-----------LTLRKTFGLFANVRPAKSIEGY-------KTTYENVNLVLIRENTEG 154
N L +R +FAN+RPA + + E V+L+++RE T G
Sbjct: 120 DNNEKHLRPEKGLLQIRAALKVFANLRPATVLPQLVDASTLKREVAEGVDLMVVRELTGG 179
Query: 155 EYSGIEHVVAPG-----VVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRL 209
Y G + V + ++ +R+ R AFE AR R K+ V K+ +
Sbjct: 180 IYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFETARK-RRGKLCSVDKANVLE- 237
Query: 210 ADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXX 269
A L+ L+SEYPD+EL +DN ++ V+ P+ +D +V N++GDI
Sbjct: 238 ASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVT--NNIFGDILSDEAS 295
Query: 270 XXXXXXXXXXXXANIGHTVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNH-MGLTEH 328
+ +FE +HGSAPDIAGQ+KANP A +LS+ M+L + +G +
Sbjct: 296 MITGSIGMLPSASLSDSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKA 355
Query: 329 ADKIEKAVLTTIASDAKNRTGDL 351
A +IE AVL +A + RTGD+
Sbjct: 356 AKRIEDAVL--VALNNGFRTGDI 376
>At5g14200 [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 409
Score = 117 bits (294), Expect = 2e-26
Identities = 107/351 (30%), Positives = 166/351 (46%), Gaps = 40/351 (11%)
Query: 30 NPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNG----LTTIPD 85
+P +Y ++ + GDG+GPE+ K + A +E D + V G L +P
Sbjct: 41 SPGKKRYNIALLPGDGIGPEVISVAKNVLQKAG-SLEGLEFDFKEMPVGGAALDLVGVPL 99
Query: 86 PA---VASINKNLIALKGPLATPIGKGHRSLN-----LTLRKTFGLFANVRPAKSIEGY- 136
P A+ + I L K + L LR+ +FAN+RPA +
Sbjct: 100 PEETFTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLV 159
Query: 137 ------KTTYENVNLVLIRENTEGEYSGIEHVVAPG-----VVQSIKLITQDASERVIRY 185
K E V+++++RE T G Y G + V S ++ +R+ R
Sbjct: 160 DASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARV 219
Query: 186 AFEYARAVDRSKVLVVHKSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQH 245
AFE AR R K+ V K+ + A L+ L+SEYPD+EL +DN ++ ++
Sbjct: 220 AFETARK-RRGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRD 277
Query: 246 PEAYDDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHT-VSIFEAVHGSAPDIAGQ 304
P+ +D +V N++GDI A++G + +FE +HGSAPDIAGQ
Sbjct: 278 PKQFDTIVT--NNIFGDILSDEASMITGSIGMLPS-ASLGESGPGLFEPIHGSAPDIAGQ 334
Query: 305 NKANPTALLLSSVMMLNH-MGLTEHADKIEKAVLTTIASDAKN---RTGDL 351
+KANP A +LS+ M+L + +G + A +IE AV+ DA N RTGD+
Sbjct: 335 DKANPLATILSAAMLLKYGLGEEKAAKRIEDAVV-----DALNKGFRTGDI 380
>At1g31180 [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 404
Score = 115 bits (288), Expect = 1e-25
Identities = 104/351 (29%), Positives = 166/351 (46%), Gaps = 40/351 (11%)
Query: 30 NPKTGKYTVSFIEGDGVGPEISKSVKAIFSAAKVPIEWESCDVSPIFVNG----LTTIPD 85
+P +Y ++ + GDG+GPE+ K + A ++ D + G L +P
Sbjct: 38 SPVKKRYNITLLPGDGIGPEVISVAKNVLQKAGF-LQGLEFDFQEMPFGGAALDLVGVPL 96
Query: 86 P---AVASINKNLIALKGPLATPIGKGHRSLN-----LTLRKTFGLFANVRPAKSIEGY- 136
P + A+ + I L K + L L +R+ +FAN+RPA +
Sbjct: 97 PEETSTAAKQSDAILLGAIGGYKWDKNEKHLRPEMGLLNIRRDLNVFANLRPATVLPQLV 156
Query: 137 ------KTTYENVNLVLIRENTEGEYSGIEHVVAPG-----VVQSIKLITQDASERVIRY 185
K + V+++++RE T G Y G + V + ++ +R+ R
Sbjct: 157 DASTLKKEVAQGVDMMIVRELTGGIYFGEPRGITINENGEEVGFNTEIYAAHEIDRIARV 216
Query: 186 AFEYARAVDRSKVLVVHKSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQH 245
AFE AR R K+ V K+ + A L+ L+SEYPD+EL +DN ++ V+
Sbjct: 217 AFETARK-RRGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRD 274
Query: 246 PEAYDDVVVVCPNLYGDIXXXXXXXXXXXXXXXXXXANIGHT-VSIFEAVHGSAPDIAGQ 304
P+ +D +V N++GDI A++G + +FE +HGSAPDIAGQ
Sbjct: 275 PKQFDTIVT--NNIFGDILSDEASMITGSIGMLPS-ASLGESGPGLFEPIHGSAPDIAGQ 331
Query: 305 NKANPTALLLSSVMMLNH-MGLTEHADKIEKAVLTTIASDAKN---RTGDL 351
+KANP A +LS+ M+L + +G + A IE AV+ DA N RTGD+
Sbjct: 332 DKANPLATILSAAMLLKYGLGEEKAAKMIEDAVV-----DALNKGFRTGDI 377
>YCL018w [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 364
Score = 90.5 bits (223), Expect = 4e-18
Identities = 99/364 (27%), Positives = 159/364 (43%), Gaps = 50/364 (13%)
Query: 41 IEGDGVGPEIS-------KSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIPDPAVASINK 93
+ GD VG EI+ K++ + S K E + I G+ +PD A+ + K
Sbjct: 10 LPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVP-LPDEALEASKK 68
Query: 94 NLIALKGPLATPIGKGHRSLN-----LTLRKTFGLFANVRPAK-------SIEGYKTTY- 140
L G + P G S+ L +RK L+AN+RP + K +
Sbjct: 69 ADAVLLGAVGGPKW-GTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKPQFA 127
Query: 141 ENVNLVLIRENTEGEYSGI-EHVVAPGVVQSIKLITQDASERVIRYAFEYAR-------- 191
+ + V++RE G Y G + GV + T +R+ R A A
Sbjct: 128 KGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQHEPPLPI 187
Query: 192 -AVDRSKVLVVHKSTIQRLADGLFVDVAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYD 250
++D++ VL S + R V + + +E+P +++Q +L+D+ + V++P +
Sbjct: 188 WSLDKANVLA--SSRLWRKT------VEETIKNEFPTLKVQHQLIDSAAMILVKNPTHLN 239
Query: 251 DVVVVCPNLYGDIXXXXXXXXXXX-----XXXXXXXANIGHTVSIFEAVHGSAPDIAGQN 305
+++ N++GDI + ++E HGSAPD+ +N
Sbjct: 240 GIIITS-NMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLP-KN 297
Query: 306 KANPTALLLSSVMMLN-HMGLTEHADKIEKAVLTTIASDAKNRTGDLGGSASTSSFTDAV 364
K NP A +LS+ MML + L E IE AV + DA RTGDLGGS ST+ DAV
Sbjct: 298 KVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVL--DAGIRTGDLGGSNSTTEVGDAV 355
Query: 365 IERL 368
E +
Sbjct: 356 AEEV 359
>SPBC1A4.02c [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 220
Score = 76.3 bits (186), Expect = 7e-14
Identities = 52/164 (31%), Positives = 78/164 (46%), Gaps = 13/164 (7%)
Query: 217 VAKKLSSEYPDIELQTELLDNTVLKTVQHPEAYDDVVVVCPNLYGDIXXXXXXXXXXXXX 276
VAK EYP + L+ +L+D+ + V+ P + VV+ NL+GDI
Sbjct: 54 VAKIFKEEYPHLTLKNQLIDSAAMLLVKSPRTLNGVVLT-DNLFGDIISDEASVIPGSLG 112
Query: 277 XXXXXANIG-------HTVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNH-MGLTEH 328
+ G + E +HGSAPDIAG+ NP +LS+ ++L + + +
Sbjct: 113 LLPSASLSGVVGKSEEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPKE 172
Query: 329 ADKIEKAVLTTIASDAKNRTG----DLGGSASTSSFTDAVIERL 368
A+ IE AV + + G DLGG AST+ T AV+E L
Sbjct: 173 AEAIEAAVRKVLDDTSIGGRGLYTRDLGGEASTADITKAVVEEL 216
>7302952 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 368
Score = 73.9 bits (180), Expect = 3e-13
Identities = 49/219 (22%), Positives = 108/219 (48%), Gaps = 13/219 (5%)
Query: 34 GKYTVSFIEGDGV-GPEISKSVKAIFSAAKVPIEWESCDVSPIFVNGLTTIPDPAVASIN 92
G TVS + G + G + ++ V ++ S+++VP+E + + D S+
Sbjct: 42 GINTVSLVTGTTIIGQQGAQFVSSLLSSSRVPVEVQVIEAGQ---------DDEYFHSVL 92
Query: 93 KNLIALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGYKTTYENVNLVLIRENT 152
+N A+ ++L + L+ +S G+K + V++ LI +N
Sbjct: 93 RNRTAVHVDNQADAEAKQKALKIC--NDLDLYVFKTRTRSFPGFKCRFPGVDIQLIGQNN 150
Query: 153 EGEYSGIEHVVAPGVVQSIKLITQDASERVIRYAFEYARAVDRSKVLVVHKSTIQRLADG 212
G ++ +E+ GVV+++ +++Q +++ +RYAF+ A R +V +++K+ ++DG
Sbjct: 151 MGIFNELEYSPVEGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPISDG 210
Query: 213 LFVDVAKKLSSEYPD-IELQTELLDNTVLKTVQHPEAYD 250
V+ A++L Y D +EL+ ++ + + + P +D
Sbjct: 211 SLVEAAQRLHCHYKDCLELELMEVEEAISRLMTEPTYFD 249
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.133 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,348,481
Number of Sequences: 60738
Number of extensions: 740743
Number of successful extensions: 1933
Number of sequences better than 1.0e-05: 29
Number of HSP's better than 0.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1803
Number of HSP's gapped (non-prelim): 30
length of query: 368
length of database: 30,389,216
effective HSP length: 108
effective length of query: 260
effective length of database: 23,829,512
effective search space: 6195673120
effective search space used: 6195673120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)