ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1024 check: MH T KOG3601 Signal transduction mechanisms Adaptor protein GRB2, contains SH2 and SH3 domains
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1024 355362 354703 -220
(220 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPR154w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 139 4e-33
YGR136w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 107 1e-23
SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH... 82 4e-16
Hs4504111 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 67 2e-11
CE01784 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 63 4e-10
Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin 62 5e-10
SPBC1734.08 [T] KOG2199 Signal transducing adaptor protein STAM/... 62 6e-10
Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin 62 6e-10
Hs4557787 [T] KOG4225 Sorbin and SH3 domain-containing protein 59 5e-09
Hs7661670 [S] KOG1843 Uncharacterized conserved protein 58 9e-09
CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin 58 9e-09
SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding prot... 57 3e-08
Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein 57 3e-08
CE05763 [Z] KOG0162 Myosin class I heavy chain 56 4e-08
YHR016c [S] KOG1843 Uncharacterized conserved protein 55 8e-08
Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 55 1e-07
Hs11321634 [T] KOG4348 Adaptor protein CMS/SETA 55 1e-07
YDR388w [U] KOG3771 Amphiphysin 54 1e-07
Hs22060285 [T] KOG4348 Adaptor protein CMS/SETA 54 2e-07
Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA 54 2e-07
CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 54 2e-07
Hs4505195 [T] KOG0192 Tyrosine kinase specific for activated (GT... 53 3e-07
7298751 [TU] KOG1029 Endocytic adaptor protein intersectin 53 3e-07
YFR024c-a [S] KOG1843 Uncharacterized conserved protein 53 4e-07
YFR024c [S] KOG1843 Uncharacterized conserved protein 53 4e-07
Hs4506931 [IT] KOG1118 Lysophosphatidic acid acyltransferase end... 53 4e-07
Hs4506929 [IT] KOG1118 Lysophosphatidic acid acyltransferase end... 53 4e-07
Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein 53 4e-07
Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein 53 4e-07
Hs20070146 [IT] KOG1118 Lysophosphatidic acid acyltransferase en... 52 6e-07
CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endop... 52 6e-07
7300449 [IT] KOG1118 Lysophosphatidic acid acyltransferase endop... 52 6e-07
7296156 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH... 52 6e-07
Hs4505347 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and ... 52 8e-07
Hs18552166 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and... 52 8e-07
7301982 [T] KOG4348 Adaptor protein CMS/SETA 52 8e-07
Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin 52 8e-07
SPBC21D10.12 [U] KOG3771 Amphiphysin 51 1e-06
SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein 51 1e-06
7302199 [T] KOG0197 Tyrosine kinases 51 1e-06
Hs5453754 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and ... 50 2e-06
Hs5729856 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 50 2e-06
Hs4758476 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 50 2e-06
Hs16418431 [R] KOG4429 Uncharacterized conserved protein contain... 50 2e-06
CE29645 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH... 50 2e-06
CE29644 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH... 50 2e-06
CE00538 [T] KOG4225 Sorbin and SH3 domain-containing protein 50 2e-06
YHL002w [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 50 3e-06
Hs7661700 [T] KOG4225 Sorbin and SH3 domain-containing protein 50 3e-06
Hs5454056 [T] KOG4225 Sorbin and SH3 domain-containing protein 50 3e-06
Hs4507743 [T] KOG0197 Tyrosine kinases 50 3e-06
7303308 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 50 3e-06
Hs4557377 [T] KOG0197 Tyrosine kinases 49 4e-06
Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 49 4e-06
CE25944 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 49 4e-06
Hs4885611 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 49 7e-06
Hs4505573 [F] KOG2070 Guanine nucleotide exchange factor 49 7e-06
Hs22027528 [F] KOG2070 Guanine nucleotide exchange factor 49 7e-06
Hs4507429 [T] KOG0197 Tyrosine kinases 48 9e-06
Hs20533142 [O] KOG2177 Predicted E3 ubiquitin ligase 48 9e-06
CE16651 [T] KOG4225 Sorbin and SH3 domain-containing protein 48 9e-06
7300664_2 [TUZ] KOG2856 Adaptor protein PACSIN 48 9e-06
>YPR154w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 215
Score = 139 bits (349), Expect = 4e-33
Identities = 82/218 (37%), Positives = 104/218 (47%), Gaps = 9/218 (4%)
Query: 4 VEESVATIKSELKYLKEQGALAELAYKDIESLLP-RVRPQPPVADTMGQNNEIVEALYAF 62
+ S+ I++EL +LK ++ Y I LP + P + + E VEALY F
Sbjct: 6 INRSLTNIRTELDFLKGSNVISNDVYDQINKSLPAKWDPANAPRNASPASLEYVEALYQF 65
Query: 63 QPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKDVEKRSSSATP 122
PQQDGDL LKPGDK+++LEKLSPEWYKG CNG+ G+FP+NYVK S +
Sbjct: 66 DPQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGIFPANYVKPA--------FSGSNG 117
Query: 123 VANLPQYAAYTXXXXXXXXXXXXXXXXXXXXXFTGXXXXXXXXXXXXXXXXXXXXXXXXX 182
+NLP Y F
Sbjct: 118 PSNLPPPPQYKAQELQQIPTQNSAASSYQQQPFPPPSTNYYQQPQQQPQQAPPPQQQQQQ 177
Query: 183 XSSHQGSAAFKKFGSKLGNAAIFGAGATIGSDLVNSIF 220
+ K FGSKLGNAAIFGAGA+IGSD+VN+IF
Sbjct: 178 QQHQSSHSHLKSFGSKLGNAAIFGAGASIGSDIVNNIF 215
>YGR136w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 241
Score = 107 bits (267), Expect = 1e-23
Identities = 55/121 (45%), Positives = 79/121 (64%), Gaps = 8/121 (6%)
Query: 4 VEESVATIKSELKYLKEQGALAELAYKDIESLLPRV----RPQPPVADTMGQNNEIVEAL 59
V S+ I++EL++LKE ++ ++ I S LP + P ADT E VEAL
Sbjct: 6 VNRSLKNIRNELEFLKESNVISGDIFELINSKLPEKWDGNQRSPQNADT----EEYVEAL 61
Query: 60 YAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKDVEKRSSS 119
Y F+ QQDGDL+LK GDKI++LEK+SP+WY+GK N ++G+FP+NYVK T+ +S+
Sbjct: 62 YDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGKSNNKIGIFPANYVKPAFTRSASPKSAE 121
Query: 120 A 120
A
Sbjct: 122 A 122
Score = 58.2 bits (139), Expect = 9e-09
Identities = 28/36 (77%), Positives = 31/36 (85%)
Query: 185 SHQGSAAFKKFGSKLGNAAIFGAGATIGSDLVNSIF 220
S S+AFK FGSKLGNAAIFGAG+ IGSD+VNSIF
Sbjct: 206 SSGASSAFKSFGSKLGNAAIFGAGSAIGSDIVNSIF 241
>SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 296
Score = 82.4 bits (202), Expect = 4e-16
Identities = 55/180 (30%), Positives = 79/180 (43%), Gaps = 13/180 (7%)
Query: 41 PQPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVF 100
P P +T +N E V A+Y F GDL G+ I +LE ++ +W++G+ NG+ G+F
Sbjct: 130 PSYPGPNTAHKNVERVLAMYDFPGPDAGDLGFHAGEVIIVLEHVNNDWWRGELNGKEGIF 189
Query: 101 PSNYVKSVDTKDVEKRSSSATPVANLPQYAAYTXXXXXXXXXXXXXXXXXXXXXFTGXXX 160
PSNYV+ ++ V+ + P N P A+ +
Sbjct: 190 PSNYVRLLEDSAVKAQPPPPPPQQNYPPAAS-----------SSAPPMQYQQTAYPPQQA 238
Query: 161 XXXXXXXXXXXXXXXXXXXXXXXSSHQGSAAFKKFGSKLGNAAIFGAGATIGSDLVNSIF 220
H + FKK GS LG+A +FGAGAT G+DLVNSIF
Sbjct: 239 PYPPVQAYPQAPQQPIVVAQPTEHKHSST--FKKIGSGLGSAFVFGAGATAGADLVNSIF 296
>Hs4504111 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 217
Score = 67.0 bits (162), Expect = 2e-11
Identities = 27/59 (45%), Positives = 39/59 (65%)
Query: 51 QNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVD 109
Q V+AL+ F PQ+DG+L + GD I +++ P W+KG C+GQ G+FP NYV V+
Sbjct: 156 QQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVN 214
>CE01784 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 228
Score = 62.8 bits (151), Expect = 4e-10
Identities = 30/77 (38%), Positives = 46/77 (58%), Gaps = 3/77 (3%)
Query: 49 MGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
M + V+AL+ F PQ+ G+LA K GD I ++ K P W++G+ N + G+FPSNYV
Sbjct: 152 MNVETKFVQALFDFNPQESGELAFKRGDVITLINKDDPNWWEGQLNNRRGIFPSNYVCPY 211
Query: 109 DTKDVEKRSSSATPVAN 125
++ K +S+ P N
Sbjct: 212 NS---NKSNSNVAPGFN 225
>Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 223
Score = 62.4 bits (150), Expect = 5e-10
Identities = 29/71 (40%), Positives = 42/71 (58%), Gaps = 1/71 (1%)
Query: 42 QPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFP 101
+PP + + +++ +Y + Q D +LA G I IL K P+W+KG+ NGQVG+FP
Sbjct: 150 EPPKSTALAAVCQVI-GMYDYTAQNDDELAFNKGQIINILNKEDPDWWKGEVNGQVGLFP 208
Query: 102 SNYVKSVDTKD 112
SNYVK D
Sbjct: 209 SNYVKLTTDMD 219
>SPBC1734.08 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 373
Score = 62.0 bits (149), Expect = 6e-10
Identities = 28/65 (43%), Positives = 40/65 (61%)
Query: 56 VEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKDVEK 115
V ALY F + G+L+ K GD I +LE + +W+KG C VG+FP NYV+ V +E+
Sbjct: 220 VRALYDFAATEQGELSFKKGDIILVLESVYKDWWKGSCKNAVGIFPVNYVQRVVEPTIEQ 279
Query: 116 RSSSA 120
+ SA
Sbjct: 280 QRQSA 284
>Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1221
Score = 62.0 bits (149), Expect = 6e-10
Identities = 28/71 (39%), Positives = 42/71 (58%), Gaps = 1/71 (1%)
Query: 42 QPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFP 101
+PP + + +++ +Y + Q D +LA G I +L K P+W+KG+ NGQVG+FP
Sbjct: 1147 EPPKSTALAAVCQVI-GMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFP 1205
Query: 102 SNYVKSVDTKD 112
SNYVK D
Sbjct: 1206 SNYVKLTTDMD 1216
>Hs4557787 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 526
Score = 58.9 bits (141), Expect = 5e-09
Identities = 25/59 (42%), Positives = 40/59 (67%)
Query: 56 VEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKDVE 114
VEAL++++ Q DL + GD I +L K++ EW +G+C G+VG+FP +V+ T D+E
Sbjct: 462 VEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLE 520
>Hs7661670 [S] KOG1843 Uncharacterized conserved protein
Length = 246
Score = 58.2 bits (139), Expect = 9e-09
Identities = 27/63 (42%), Positives = 42/63 (65%), Gaps = 4/63 (6%)
Query: 47 DTMGQNNEIVE--ALYAFQPQQDGDLALKPGDKIEILEKLSP--EWYKGKCNGQVGVFPS 102
+ +G N+ +E ALY+F+ QQ GDL + GD+I ++ K +W++GK GQ G+FP+
Sbjct: 181 ERVGNLNQPIEVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPA 240
Query: 103 NYV 105
NYV
Sbjct: 241 NYV 243
>CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 58.2 bits (139), Expect = 9e-09
Identities = 33/87 (37%), Positives = 49/87 (55%), Gaps = 8/87 (9%)
Query: 46 ADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYV 105
A ++ +Y F+ + DLAL GD I +LEK + EW+KG+CNG+ G+FP+NYV
Sbjct: 889 ASETAPQQQLYTVIYDFEAVETTDLALHVGDTILVLEK-NDEWWKGRCNGREGIFPANYV 947
Query: 106 K-SVDTKDVEKRSSSATPVANLPQYAA 131
+ SV +++ TP P AA
Sbjct: 948 EISV------QQAGDPTPPTQAPTPAA 968
>SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding proteins
Length = 857
Score = 56.6 bits (135), Expect = 3e-08
Identities = 23/66 (34%), Positives = 41/66 (61%)
Query: 43 PPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPS 102
PP G + V+A+Y +Q Q+D +L+ + I ++ + P W++G+C+G G+FPS
Sbjct: 792 PPAEPQAGGPGKSVKAIYDYQAQEDNELSFFEDEIIANVDCVDPNWWEGECHGHRGLFPS 851
Query: 103 NYVKSV 108
NYV+ +
Sbjct: 852 NYVEEI 857
>Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 790
Score = 56.6 bits (135), Expect = 3e-08
Identities = 22/50 (44%), Positives = 34/50 (68%)
Query: 59 LYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
L+ F +Q DL L G+ + +LEK+ +WY+G C Q+G+FP+NYVK +
Sbjct: 503 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI 552
Score = 50.8 bits (120), Expect = 1e-06
Identities = 28/82 (34%), Positives = 44/82 (53%), Gaps = 5/82 (6%)
Query: 30 KDIESLLPRV--RPQPPVADTM---GQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKL 84
+D E + P V RP P A +M +ALY F+ + + +L+ K GD I LE +
Sbjct: 704 QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESV 763
Query: 85 SPEWYKGKCNGQVGVFPSNYVK 106
+W G+ G+ G+FP NY++
Sbjct: 764 DDDWMSGELMGKSGIFPKNYIQ 785
Score = 50.8 bits (120), Expect = 1e-06
Identities = 21/53 (39%), Positives = 36/53 (67%)
Query: 54 EIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVK 106
E EAL++F + DL+ K GD+I+ILE+L +W +G+ + G+FP+ +V+
Sbjct: 664 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 716
>CE05763 [Z] KOG0162 Myosin class I heavy chain
Length = 1100
Score = 55.8 bits (133), Expect = 4e-08
Identities = 25/67 (37%), Positives = 42/67 (62%), Gaps = 3/67 (4%)
Query: 40 RPQPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGV 99
+P PP + N +V A+Y ++ Q +L+ + G +IE++ K + W++GK N +VG+
Sbjct: 1036 KPPPPAKPKL---NPVVIAVYPYEAQDVDELSFEAGAEIELMNKDASGWWQGKVNNRVGL 1092
Query: 100 FPSNYVK 106
FP NYVK
Sbjct: 1093 FPGNYVK 1099
>YHR016c [S] KOG1843 Uncharacterized conserved protein
Length = 468
Score = 55.1 bits (131), Expect = 8e-08
Identities = 26/51 (50%), Positives = 35/51 (67%), Gaps = 2/51 (3%)
Query: 58 ALYAFQPQQDGDLALKPGDKIEILEKLSPE--WYKGKCNGQVGVFPSNYVK 106
ALY F +Q GDLA K GD I IL+K + W+ G+ NG+ G+FP+NYV+
Sbjct: 416 ALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWWTGRTNGKEGIFPANYVR 466
>Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 540
Score = 54.7 bits (130), Expect = 1e-07
Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 5 EESVATIKSELKYLKEQGALAELAYKDIESLLPRVRPQPPVADTMGQNNEIVEALYAFQP 64
E+ I+ LK ++Q Y SLL + + V A+Y F+
Sbjct: 174 EDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHE----------GRKVRAIYDFEA 223
Query: 65 QQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKDVE 114
+D +L K G+ I +L+ P W+KG+ + +G+FPSN+V + T + E
Sbjct: 224 AEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPE 273
>Hs11321634 [T] KOG4348 Adaptor protein CMS/SETA
Length = 639
Score = 54.7 bits (130), Expect = 1e-07
Identities = 31/116 (26%), Positives = 59/116 (50%), Gaps = 11/116 (9%)
Query: 8 VATIKSELKYLKEQGALAELAYKDIESLLPRV----------RPQPPVADTMGQNNEI-V 56
V IK E ++ + + + ++ SL+ R+ +P P + + +
Sbjct: 54 VKEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQC 113
Query: 57 EALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKD 112
+ L+ + PQ + +L LK GD I+I E++ W+ G N ++G+FPSN+VK ++ D
Sbjct: 114 KVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTD 169
>YDR388w [U] KOG3771 Amphiphysin
Length = 482
Score = 54.3 bits (129), Expect = 1e-07
Identities = 29/66 (43%), Positives = 37/66 (55%), Gaps = 2/66 (3%)
Query: 43 PPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSP--EWYKGKCNGQVGVF 100
P A E V ALY +Q Q GDL+ G IEI+++ EW+ G+ NGQ GVF
Sbjct: 413 PAAAVAAAPGVETVTALYDYQAQAAGDLSFPAGAVIEIVQRTPDVNEWWTGRYNGQQGVF 472
Query: 101 PSNYVK 106
P NYV+
Sbjct: 473 PGNYVQ 478
>Hs22060285 [T] KOG4348 Adaptor protein CMS/SETA
Length = 150
Score = 53.5 bits (127), Expect = 2e-07
Identities = 21/58 (36%), Positives = 38/58 (65%)
Query: 57 EALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKDVE 114
+ +++ PQ D +L LK GD IE++ ++ W++G NG+ G+FPSN++K + + E
Sbjct: 45 QVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDE 102
>Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA
Length = 665
Score = 53.5 bits (127), Expect = 2e-07
Identities = 21/58 (36%), Positives = 38/58 (65%)
Query: 57 EALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKDVE 114
+ +++ PQ D +L LK GD IE++ ++ W++G NG+ G+FPSN++K + + E
Sbjct: 104 QVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDE 161
Score = 48.9 bits (115), Expect = 5e-06
Identities = 27/95 (28%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 30 KDIESLLPRVRPQPPVA----DTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEK-- 83
K I LP P + D+ ++ + + ++ ++ Q D +L +K GD + ++ K
Sbjct: 242 KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDC 301
Query: 84 LSPEWYKGKCNGQVGVFPSNYVKSVDTKDVEKRSS 118
+ W++G+ NG+ GVFP N+VK + D EK +
Sbjct: 302 IDVGWWEGELNGRRGVFPDNFVKLL-PPDFEKEGN 335
>CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 449
Score = 53.5 bits (127), Expect = 2e-07
Identities = 38/122 (31%), Positives = 59/122 (48%), Gaps = 8/122 (6%)
Query: 5 EESVA-TIKSELKYLKEQGALAELAYKDIESLLPRVRPQPPVADTMGQNNEI-VEALYAF 62
EE++A I + L ++Q E A K ++ P + P T E V ALY F
Sbjct: 167 EEAIAKAIAASLADAEKQ----EKAKKSTSTMYPSAKASSPAVQTNSNIPEKNVRALYDF 222
Query: 63 QPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV--DTKDVEKRSSSA 120
+ + +L+ GD I I ++ +P W+ G+ Q G+FPS++V + D K E SS
Sbjct: 223 EAAESNELSFVAGDIITITDESNPHWWTGRIGTQQGLFPSSFVTNQLDDLKSKETDSSQK 282
Query: 121 TP 122
P
Sbjct: 283 AP 284
>Hs4505195 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 847
Score = 53.1 bits (126), Expect = 3e-07
Identities = 25/61 (40%), Positives = 40/61 (64%), Gaps = 5/61 (8%)
Query: 50 GQNNEIVEALYAFQPQQDGDLALKPGDKIEILEK---LSPE--WYKGKCNGQVGVFPSNY 104
G N + AL+ ++P +LAL+ GD++E+L + +S + W+ G+ GQVG+FPSNY
Sbjct: 40 GYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNY 99
Query: 105 V 105
V
Sbjct: 100 V 100
>7298751 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 53.1 bits (126), Expect = 3e-07
Identities = 25/66 (37%), Positives = 38/66 (56%)
Query: 56 VEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKDVEK 115
V ALY ++ Q D +L+ D I +L + PEW++G+ NG G+FPSNYV T
Sbjct: 1030 VIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSGKPA 1089
Query: 116 RSSSAT 121
+++ T
Sbjct: 1090 KANGTT 1095
Score = 49.7 bits (117), Expect = 3e-06
Identities = 27/82 (32%), Positives = 45/82 (53%), Gaps = 9/82 (10%)
Query: 58 ALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKDVEKRS 117
A Y ++ ++GDL+ G+ + +++K EW+ G + G+FPSNYV+ D +
Sbjct: 786 AAYPYESAEEGDLSFSAGEMVMVIKK-EGEWWTGTIGSRTGMFPSNYVQKADVGTAS--T 842
Query: 118 SSATPVANLPQ------YAAYT 133
++A PV +L Q AAYT
Sbjct: 843 AAAEPVESLDQETTLNGNAAYT 864
>YFR024c-a [S] KOG1843 Uncharacterized conserved protein
Length = 451
Score = 52.8 bits (125), Expect = 4e-07
Identities = 24/53 (45%), Positives = 36/53 (67%), Gaps = 2/53 (3%)
Query: 58 ALYAFQPQQDGDLALKPGDKIEILEKLSPE--WYKGKCNGQVGVFPSNYVKSV 108
ALY+F ++ GDL + GD I IL+K + W+ G+ NG+ G+FP+NYV+ V
Sbjct: 399 ALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV 451
>YFR024c [S] KOG1843 Uncharacterized conserved protein
Length = 373
Score = 52.8 bits (125), Expect = 4e-07
Identities = 24/53 (45%), Positives = 36/53 (67%), Gaps = 2/53 (3%)
Query: 58 ALYAFQPQQDGDLALKPGDKIEILEKLSPE--WYKGKCNGQVGVFPSNYVKSV 108
ALY+F ++ GDL + GD I IL+K + W+ G+ NG+ G+FP+NYV+ V
Sbjct: 321 ALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV 373
>Hs4506931 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 352
Score = 52.8 bits (125), Expect = 4e-07
Identities = 21/49 (42%), Positives = 31/49 (62%)
Query: 58 ALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVK 106
ALY F+P+ +G+L K GD I + ++ WY+G +G G FP NYV+
Sbjct: 297 ALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVE 345
>Hs4506929 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 368
Score = 52.8 bits (125), Expect = 4e-07
Identities = 21/50 (42%), Positives = 32/50 (64%)
Query: 57 EALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVK 106
+ALY F+P+ DG+L GD I + ++ WY+G +GQ G FP +YV+
Sbjct: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYVE 361
>Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 666
Score = 52.8 bits (125), Expect = 4e-07
Identities = 21/52 (40%), Positives = 36/52 (68%)
Query: 57 EALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
+A+Y F+ Q +L+ K GD + IL K+ WY+G+ +G+VG+FP +YV+ +
Sbjct: 435 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 486
Score = 52.0 bits (123), Expect = 6e-07
Identities = 31/89 (34%), Positives = 50/89 (55%), Gaps = 6/89 (6%)
Query: 32 IESLLPRVRPQPPVADTMGQNNEIVEAL--YAFQPQQDGDLALKPGDKIEILEKLSPEWY 89
+E L P + QP Q EI EA+ Y F + +L+L+ GD++ +L+++ WY
Sbjct: 483 VEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWY 542
Query: 90 KGKCNG--QVGVFPSNYVKSV--DTKDVE 114
+GK G + G+FP +YV+ V +TK E
Sbjct: 543 EGKIPGTNRQGIFPVSYVEVVKKNTKGAE 571
>Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 1100
Score = 52.8 bits (125), Expect = 4e-07
Identities = 21/52 (40%), Positives = 36/52 (68%)
Query: 57 EALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
+A+Y F+ Q +L+ K GD + IL K+ WY+G+ +G+VG+FP +YV+ +
Sbjct: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920
Score = 52.0 bits (123), Expect = 6e-07
Identities = 31/89 (34%), Positives = 50/89 (55%), Gaps = 6/89 (6%)
Query: 32 IESLLPRVRPQPPVADTMGQNNEIVEAL--YAFQPQQDGDLALKPGDKIEILEKLSPEWY 89
+E L P + QP Q EI EA+ Y F + +L+L+ GD++ +L+++ WY
Sbjct: 917 VEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWY 976
Query: 90 KGKCNG--QVGVFPSNYVKSV--DTKDVE 114
+GK G + G+FP +YV+ V +TK E
Sbjct: 977 EGKIPGTNRQGIFPVSYVEVVKKNTKGAE 1005
>Hs20070146 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 355
Score = 52.0 bits (123), Expect = 6e-07
Identities = 24/68 (35%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 45 VADTMGQN----NEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVF 100
V T G N LY F+P+ G+L K GD I + ++ WY+G +G+ G F
Sbjct: 283 VVKTTGSNIPMDQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFF 342
Query: 101 PSNYVKSV 108
P NYV+ +
Sbjct: 343 PINYVEVI 350
>CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 443
Score = 52.0 bits (123), Expect = 6e-07
Identities = 23/64 (35%), Positives = 37/64 (56%), Gaps = 3/64 (4%)
Query: 43 PPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPS 102
PP++ Q AL+ F Q +G+L K G IE++ ++ WY+G+ NG+ G+FP
Sbjct: 377 PPLSQ---QQKPQCRALFDFDAQSEGELDFKEGTLIELVSQIDENWYEGRVNGKTGLFPV 433
Query: 103 NYVK 106
YV+
Sbjct: 434 TYVQ 437
>7300449 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 368
Score = 52.0 bits (123), Expect = 6e-07
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 1/92 (1%)
Query: 18 LKEQGALAELAYKDIESLLPRVRPQPPVADT-MGQNNEIVEALYAFQPQQDGDLALKPGD 76
L E G + ++ P P +A T Q +ALY F+P+ G+LA K D
Sbjct: 271 LNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFEPENPGELAFKEND 330
Query: 77 KIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
I +L ++ W++G NG+ G FP + V V
Sbjct: 331 IITLLNRVDDNWFEGAVNGRTGYFPQSRVSFV 362
>7296156 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 548
Score = 52.0 bits (123), Expect = 6e-07
Identities = 24/59 (40%), Positives = 41/59 (68%), Gaps = 3/59 (5%)
Query: 54 EIVEALYAFQPQQDGDLALKPGDKIEILEK--LSPEWYKGKCN-GQVGVFPSNYVKSVD 109
+IV ALY+F D +L+ + GD++EI+++ P+WYK + N GQVG+ P NY++ ++
Sbjct: 327 DIVVALYSFTSNNDQELSFEKGDRLEIVDRPASDPDWYKARNNQGQVGLVPRNYLQELN 385
>Hs4505347 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 381
Score = 51.6 bits (122), Expect = 8e-07
Identities = 23/59 (38%), Positives = 38/59 (63%), Gaps = 1/59 (1%)
Query: 60 YAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYV-KSVDTKDVEKRS 117
+A+ +++ +L+L G ++ ++EK S W++G NGQ+G FPSNYV + VD E S
Sbjct: 121 FAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPS 179
>Hs18552166 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 380
Score = 51.6 bits (122), Expect = 8e-07
Identities = 23/59 (38%), Positives = 38/59 (63%), Gaps = 1/59 (1%)
Query: 60 YAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYV-KSVDTKDVEKRS 117
+A+ +++ +L+L G ++ ++EK S W++G NGQ+G FPSNYV + VD E S
Sbjct: 120 FAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPS 178
>7301982 [T] KOG4348 Adaptor protein CMS/SETA
Length = 352
Score = 51.6 bits (122), Expect = 8e-07
Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 10/96 (10%)
Query: 36 LPRVRPQPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPE--WYKGKC 93
+P + P+P E + + PQ D +L LK D I ++ P+ W+KG+
Sbjct: 246 VPMLPPKP--------QREFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKGEI 297
Query: 94 NGQVGVFPSNYVKSVDTKDVEKRSSSATPVANLPQY 129
G+VGVFP N+VK + +V P N Q+
Sbjct: 298 RGKVGVFPDNFVKMLAPSEVSTSHQCIFPPLNWRQF 333
Score = 51.6 bits (122), Expect = 8e-07
Identities = 22/67 (32%), Positives = 38/67 (55%)
Query: 47 DTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVK 106
D +N + +Y++ D +L L GD IE L ++ W++G+ +VGVFPSN+V+
Sbjct: 89 DKSATSNRRCKVIYSYTQVNDDELTLAVGDVIEFLGEVEEGWWRGRLRSKVGVFPSNFVQ 148
Query: 107 SVDTKDV 113
++ V
Sbjct: 149 HIEPSPV 155
>Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1177
Score = 51.6 bits (122), Expect = 8e-07
Identities = 21/57 (36%), Positives = 33/57 (57%)
Query: 56 VEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSVDTKD 112
V A+Y + + +L+ G I ++ K P+W++G+ NG G+FPSNYVK D
Sbjct: 1116 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD 1172
>SPBC21D10.12 [U] KOG3771 Amphiphysin
Length = 466
Score = 51.2 bits (121), Expect = 1e-06
Identities = 27/68 (39%), Positives = 36/68 (52%), Gaps = 2/68 (2%)
Query: 41 PQPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKL--SPEWYKGKCNGQVG 98
P P A E V ALY + Q GDL+ GD+IE++ + EW+ G+ NG G
Sbjct: 397 PPPAPAPAAAPAAEHVVALYDYAAQAAGDLSFHAGDRIEVVSRTDNQNEWWIGRLNGAQG 456
Query: 99 VFPSNYVK 106
FP NYV+
Sbjct: 457 QFPGNYVQ 464
>SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein
Length = 430
Score = 50.8 bits (120), Expect = 1e-06
Identities = 24/62 (38%), Positives = 40/62 (63%), Gaps = 4/62 (6%)
Query: 47 DTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLS--PEWYKGKCNGQVGVFPSNY 104
D++G N A+Y+F +Q GDL+ + GD I+I+E+ +W+ G+ + G+FP+NY
Sbjct: 369 DSLGPNQ--ARAMYSFAGEQPGDLSFQKGDIIDIVERSGSHDDWWTGRIGYREGIFPANY 426
Query: 105 VK 106
VK
Sbjct: 427 VK 428
>7302199 [T] KOG0197 Tyrosine kinases
Length = 517
Score = 50.8 bits (120), Expect = 1e-06
Identities = 26/76 (34%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 41 PQPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWY--KGKCNGQVG 98
PQ P ++T G N +I ALY + + D DL+ + G+ +EIL +W+ + K G
Sbjct: 53 PQIPESETAGANAKIFVALYDYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTRSEG 112
Query: 99 VFPSNYVKSVDTKDVE 114
PSNYV + + + E
Sbjct: 113 YIPSNYVAKLKSIEAE 128
>Hs5453754 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 377
Score = 50.4 bits (119), Expect = 2e-06
Identities = 26/59 (44%), Positives = 36/59 (60%), Gaps = 3/59 (5%)
Query: 50 GQNNEIVEALYAFQPQQDGDLALKPGDKIEILEK--LSPEWYK-GKCNGQVGVFPSNYV 105
GQ +V+ALY F D +L + GD ++++EK PEW+K K NG VG+ P NYV
Sbjct: 189 GQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYV 247
Score = 49.3 bits (116), Expect = 4e-06
Identities = 20/46 (43%), Positives = 32/46 (69%)
Query: 60 YAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYV 105
+ + +++ +L+L G K+ ++EK S W++G NGQVG FPSNYV
Sbjct: 115 FNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYV 160
>Hs5729856 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 217
Score = 50.1 bits (118), Expect = 2e-06
Identities = 21/52 (40%), Positives = 33/52 (63%)
Query: 57 EALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
+A + F Q L+ + GD IE+LE+ P W++G+ G+VG FP +YV+ V
Sbjct: 164 QAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPV 215
>Hs4758476 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 330
Score = 50.1 bits (118), Expect = 2e-06
Identities = 18/48 (37%), Positives = 33/48 (68%)
Query: 58 ALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYV 105
ALY F+ +D +L G+ +E+L+ +P W+ G+ + ++G+FP+NYV
Sbjct: 278 ALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYV 325
>Hs16418431 [R] KOG4429 Uncharacterized conserved protein contains SH3 and FCH
domains
Length = 428
Score = 50.1 bits (118), Expect = 2e-06
Identities = 23/57 (40%), Positives = 37/57 (64%)
Query: 52 NNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
++ + +ALY+FQ +QD +L L+ GD + I EK W+ G NG+ G FP+ YV+ +
Sbjct: 361 SSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYVEEL 417
>CE29645 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 286
Score = 50.1 bits (118), Expect = 2e-06
Identities = 25/71 (35%), Positives = 42/71 (58%), Gaps = 7/71 (9%)
Query: 60 YAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKC-NGQVGVFPSNYVKSVDTK------D 112
+ ++P+ + +L L GD + ++EK + W+KG+ NG VG FPSNYV+ V+
Sbjct: 11 FTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYVEEVEASTNGNQGS 70
Query: 113 VEKRSSSATPV 123
+E R+ +A V
Sbjct: 71 IENRNPAAAAV 81
>CE29644 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 398
Score = 50.1 bits (118), Expect = 2e-06
Identities = 25/71 (35%), Positives = 42/71 (58%), Gaps = 7/71 (9%)
Query: 60 YAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKC-NGQVGVFPSNYVKSVDTK------D 112
+ ++P+ + +L L GD + ++EK + W+KG+ NG VG FPSNYV+ V+
Sbjct: 123 FTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYVEEVEASTNGNQGS 182
Query: 113 VEKRSSSATPV 123
+E R+ +A V
Sbjct: 183 IENRNPAAAAV 193
>CE00538 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 467
Score = 50.1 bits (118), Expect = 2e-06
Identities = 24/90 (26%), Positives = 45/90 (49%), Gaps = 3/90 (3%)
Query: 41 PQPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVF 100
P P A + + A+Y + + GDL G +I + +++ EW +G+C G+ G+F
Sbjct: 235 PPRPAAPSGSSSGTYATAIYDYNSNEAGDLNFAVGSQIMVTARVNEEWLEGECFGRSGIF 294
Query: 101 PSNYVKSVDTKDVEKRSSSATPVANLPQYA 130
PS +V + V + S+ ++ P Y+
Sbjct: 295 PSQFVDCPNLYQVPMKQSAP---SSAPSYS 321
>YHL002w [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 452
Score = 49.7 bits (117), Expect = 3e-06
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 3/66 (4%)
Query: 56 VEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV---DTKD 112
V ALY + +L+ + GD I +LE++ +W+KG G +G+FP NYV + ++
Sbjct: 222 VRALYDLTTNEPDELSFRKGDVITVLEQVYRDWWKGALRGNMGIFPLNYVTPIVEPSKEE 281
Query: 113 VEKRSS 118
+EK +
Sbjct: 282 IEKEKN 287
>Hs7661700 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 816
Score = 49.7 bits (117), Expect = 3e-06
Identities = 22/52 (42%), Positives = 33/52 (63%), Gaps = 2/52 (3%)
Query: 57 EALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKG--KCNGQVGVFPSNYVK 106
+ALY++ PQ D +L L+ GD ++++EK W+ G + Q G FP NYVK
Sbjct: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
>Hs5454056 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 684
Score = 49.7 bits (117), Expect = 3e-06
Identities = 22/52 (42%), Positives = 33/52 (63%), Gaps = 2/52 (3%)
Query: 57 EALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKG--KCNGQVGVFPSNYVK 106
+ALY++ PQ D +L L+ GD ++++EK W+ G + Q G FP NYVK
Sbjct: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
>Hs4507743 [T] KOG0197 Tyrosine kinases
Length = 527
Score = 49.7 bits (117), Expect = 3e-06
Identities = 27/68 (39%), Positives = 42/68 (61%), Gaps = 2/68 (2%)
Query: 40 RPQPPVADTMGQNNEI-VEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCN-GQV 97
+P PP+ + +I V+ALY F P++ +LAL+ ++ ILEK +P W+K + G
Sbjct: 70 KPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNE 129
Query: 98 GVFPSNYV 105
G+ PSNYV
Sbjct: 130 GLIPSNYV 137
>7303308 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 211
Score = 49.7 bits (117), Expect = 3e-06
Identities = 19/51 (37%), Positives = 32/51 (62%)
Query: 55 IVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYV 105
+V+ALY F PQ+ G+L + GD I + ++ W+ G+ + G+FP+ YV
Sbjct: 156 LVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYV 206
>Hs4557377 [T] KOG0197 Tyrosine kinases
Length = 659
Score = 49.3 bits (116), Expect = 4e-06
Identities = 26/70 (37%), Positives = 37/70 (52%), Gaps = 1/70 (1%)
Query: 41 PQPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGK-CNGQVGV 99
P+P A + V ALY + P DL L+ GD+ ILE+ + W++ + NGQ G
Sbjct: 204 PEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGY 263
Query: 100 FPSNYVKSVD 109
PSNYV +
Sbjct: 264 IPSNYVTEAE 273
>Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 475
Score = 49.3 bits (116), Expect = 4e-06
Identities = 33/107 (30%), Positives = 51/107 (46%), Gaps = 9/107 (8%)
Query: 2 PSVEESVATIKSELKYLKEQGALAELAYKDIESLLPRVRPQPPVADTMGQNNEIVEALYA 61
P +ES Y +E+ A+ E Y D P PP A E V A+Y
Sbjct: 373 PVFDESPPPPPPPEDYEEEEAAVVE--YSD-----PYAEEDPPWAPR--SYLEKVVAIYD 423
Query: 62 FQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
+ ++ +L+ + G I +++K WY+G NG G+FP NYV+S+
Sbjct: 424 YTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESI 470
>CE25944 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 883
Score = 49.3 bits (116), Expect = 4e-06
Identities = 33/90 (36%), Positives = 50/90 (54%), Gaps = 10/90 (11%)
Query: 40 RPQPPVADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPE--WYKGKCNGQV 97
R PP+ + ++ A Y ++ Q+D +L L G I ++ + E WY+G+ NG+V
Sbjct: 63 RESPPI-----RASKAFVASYEYEAQKDDELNLPLGAIITLVTVETNEDGWYRGELNGKV 117
Query: 98 GVFPSNYVKSVDTKD--VE-KRSSSATPVA 124
G+FPSNY + V KD VE K+ PVA
Sbjct: 118 GLFPSNYAREVTYKDNLVEFKQDEIMLPVA 147
>Hs4885611 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 508
Score = 48.5 bits (114), Expect = 7e-06
Identities = 21/55 (38%), Positives = 33/55 (59%)
Query: 54 EIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
E V A+Y + +D +L+ G I +++K WY+G CN G+FP NYV+S+
Sbjct: 449 EKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVESI 503
>Hs4505573 [F] KOG2070 Guanine nucleotide exchange factor
Length = 646
Score = 48.5 bits (114), Expect = 7e-06
Identities = 25/75 (33%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Query: 48 TMGQNNE-IVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVK 106
T NN+ +V A + FQ + +L+ GD I + W++G NG+ G FPSNYV+
Sbjct: 2 TDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR 61
Query: 107 SVDTKDVEKRSSSAT 121
V + S T
Sbjct: 62 EVKASEKPVSPKSGT 76
>Hs22027528 [F] KOG2070 Guanine nucleotide exchange factor
Length = 782
Score = 48.5 bits (114), Expect = 7e-06
Identities = 25/75 (33%), Positives = 37/75 (49%), Gaps = 1/75 (1%)
Query: 48 TMGQNNE-IVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCNGQVGVFPSNYVK 106
T NN+ +V A + FQ + +L+ GD I + W++G NG+ G FPSNYV+
Sbjct: 159 TDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVR 218
Query: 107 SVDTKDVEKRSSSAT 121
V + S T
Sbjct: 219 EVKASEKPVSPKSGT 233
>Hs4507429 [T] KOG0197 Tyrosine kinases
Length = 631
Score = 48.1 bits (113), Expect = 9e-06
Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 40 RPQPPVA-DTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKCN-GQV 97
RP PP+ + + EIV A+Y FQ + DL L+ G + ILEK W++ + G
Sbjct: 167 RPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNE 226
Query: 98 GVFPSNYVKSVDTKDVEK 115
G PSNYV + ++++
Sbjct: 227 GYIPSNYVTGKKSNNLDQ 244
>Hs20533142 [O] KOG2177 Predicted E3 ubiquitin ligase
Length = 888
Score = 48.1 bits (113), Expect = 9e-06
Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 5/93 (5%)
Query: 20 EQGALAELAYKDIESLL----PRVRPQPPVADTMGQNNEIVEALYAFQPQQDGDLALKPG 75
+ +A + KD++S PRV+ P + Q +ALY ++ ++ GDL G
Sbjct: 100 QSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQL-PCAKALYNYEGKEPGDLKFSKG 158
Query: 76 DKIEILEKLSPEWYKGKCNGQVGVFPSNYVKSV 108
D I + ++ WY G+ NG G FP+N+V+ +
Sbjct: 159 DIIILRRQVDENWYHGEVNGIHGFFPTNFVQII 191
>CE16651 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 408
Score = 48.1 bits (113), Expect = 9e-06
Identities = 23/63 (36%), Positives = 36/63 (56%), Gaps = 2/63 (3%)
Query: 46 ADTMGQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPEWYKGKC--NGQVGVFPSN 103
A + + +E+ A+Y +QPQ++ +L L D I ++EK W+ G G G+FP N
Sbjct: 344 ASLIPKGSEMYRAVYPYQPQKEDELQLYTNDIIFVVEKCDDGWFIGTSLRTGDFGIFPGN 403
Query: 104 YVK 106
YVK
Sbjct: 404 YVK 406
>7300664_2 [TUZ] KOG2856 Adaptor protein PACSIN
Length = 481
Score = 48.1 bits (113), Expect = 9e-06
Identities = 23/59 (38%), Positives = 37/59 (61%), Gaps = 1/59 (1%)
Query: 50 GQNNEIVEALYAFQPQQDGDLALKPGDKIEILEKLSPE-WYKGKCNGQVGVFPSNYVKS 107
G+ V+ALY ++ + +L K GD E LE + W KG+ NG+VG++P+NYV++
Sbjct: 422 GEPGVPVKALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRMNGRVGLYPANYVET 480
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.311 0.131 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,193,588
Number of Sequences: 60738
Number of extensions: 379706
Number of successful extensions: 1151
Number of sequences better than 1.0e-05: 62
Number of HSP's better than 0.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 1019
Number of HSP's gapped (non-prelim): 121
length of query: 220
length of database: 30,389,216
effective HSP length: 102
effective length of query: 118
effective length of database: 24,193,940
effective search space: 2854884920
effective search space used: 2854884920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)