ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1056 good O KOG1339 Posttranslational modification, protein turnover, chaperones Aspartyl protease
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1056 366535 368301 589
(589 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR120c [O] KOG1339 Aspartyl protease 455 e-128
YDR144c [O] KOG1339 Aspartyl protease 405 e-113
YLR121c [O] KOG1339 Aspartyl protease 317 4e-86
YIR039c [O] KOG1339 Aspartyl protease 259 8e-69
YIL015w [O] KOG1339 Aspartyl protease 233 8e-61
SPAC26A3.01 [O] KOG1339 Aspartyl protease 92 2e-18
YPL154c [O] KOG1339 Aspartyl protease 86 1e-16
Hs22063875 [O] KOG1339 Aspartyl protease 83 1e-15
Hs22063872 [O] KOG1339 Aspartyl protease 83 1e-15
Hs4505757 [O] KOG1339 Aspartyl protease 82 3e-15
SPCC1795.09 [O] KOG1339 Aspartyl protease 79 3e-14
7300254 [O] KOG1339 Aspartyl protease 77 6e-14
YDR349c [O] KOG1339 Aspartyl protease 71 5e-12
7290034 [O] KOG1339 Aspartyl protease 65 4e-10
7297427 [O] KOG1339 Aspartyl protease 63 1e-09
7296075 [O] KOG1339 Aspartyl protease 63 1e-09
Hs4503145 [O] KOG1339 Aspartyl protease 61 4e-09
7297765 [O] KOG1339 Aspartyl protease 59 2e-08
7304149 [O] KOG1339 Aspartyl protease 57 1e-07
7296076 [O] KOG1339 Aspartyl protease 57 1e-07
Hs4506475 [O] KOG1339 Aspartyl protease 56 1e-07
7300255 [O] KOG1339 Aspartyl protease 55 3e-07
Hs22063919 [O] KOG1339 Aspartyl protease 55 4e-07
Hs4758754 [O] KOG1339 Aspartyl protease 53 1e-06
Hs4503143 [O] KOG1339 Aspartyl protease 52 2e-06
YGL258w-a [O] KOG1339 Aspartyl protease 52 3e-06
CE21681 [O] KOG1339 Aspartyl protease 51 4e-06
7300253 [O] KOG1339 Aspartyl protease 51 4e-06
CE20430 [O] KOG1339 Aspartyl protease 51 6e-06
>YLR120c [O] KOG1339 Aspartyl protease
Length = 569
Score = 455 bits (1171), Expect = e-128
Identities = 246/500 (49%), Positives = 321/500 (64%), Gaps = 21/500 (4%)
Query: 31 EANKKHVFMSFDKLRGNDASEASLSKRRVGHLKKRADGYVDVEIDNQNTFYSVDLEIGTP 90
++N K V + F KL G+ K+ L KRADGY ++ I NQ +FYSVDLE+GTP
Sbjct: 33 DSNSKFVKLPFHKLYGDSLENVGSDKKPEVRLLKRADGYEEIIITNQQSFYSVDLEVGTP 92
Query: 91 AQKVGVLIDTGSSDLWVPGSGNPFCXXXXXXXXXXX----QDYTALLSSLLSVFGTDVAT 146
Q V VL+DTGSSDLW+ GS NP+C +D ++ SL++ D+
Sbjct: 93 PQNVTVLVDTGSSDLWIMGSDNPYCSSNSMGSSRRRVIDKRDDSSSGGSLIN----DINP 148
Query: 147 DYTYTGIASATGSAGTQTVPTALTSGTVAATSIRSVPSSLATLDCSEFGTFDTSKSSSWQ 206
TG SA G PTA G + T+ +SVP+S AT+DC ++GTF TS SS+++
Sbjct: 149 FGWLTGTGSAIG-------PTATGLGGGSGTATQSVPASEATMDCQQYGTFSTSGSSTFR 201
Query: 207 SNDTRFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYTDSQFGVLGIGLTGSEST 266
SN+T F ISY DGTFA G +G D + L D+NVTGLSFAV+N T+S GVLGIGL E T
Sbjct: 202 SNNTYFSISYGDGTFASGTFGTDVLDLSDLNVTGLSFAVANETNSTMGVLGIGLPELEVT 261
Query: 267 YSGQLSTYN--RYQYDNFPIVLQRNGVIEKNAYSVFLNDLDADSGSILFGAVDHSKYTGT 324
YSG ++++ Y+YDNFPIVL+ +G I+ N YS++LND DA G+ILFGAVDHSKYTGT
Sbjct: 262 YSGSTASHSGKAYKYDNFPIVLKNSGAIKSNTYSLYLNDSDAMHGTILFGAVDHSKYTGT 321
Query: 325 LYTVPMVNALRSIGYTEQIRLSITLQGIGVT-SSYGNETVTQTKYPALLDTGATFCYFPX 383
LYT+P+VN L + G++ I+ +T+ GIG++ S N+T+T TK PALLD+G T Y P
Sbjct: 322 LYTIPIVNTLSASGFSSPIQFDVTINGIGISDSGSSNKTLTTTKIPALLDSGTTLTYLPQ 381
Query: 384 XXXXXXXXXXXXXXXXXXGYYFVDCDSGSDYDLVFDFGGFHIISPLSDYIVTTSSSSQCV 443
GYY +DC S ++VFDFGGFHI +PLS +I++T ++ C+
Sbjct: 382 TVVSMIATELGAQYSSRIGYYVLDCPSDDSMEIVFDFGGFHINAPLSSFILSTGTT--CL 439
Query: 444 LGILPQSDNEIT-LGDAFLTSAYVVYDLEELEISLAQASYTSGDEKIEVIRDSVPSAVAA 502
LGI+P SD+ T LGD+FLT+AYVVYDLE LEIS+AQA Y + E IE+I SVPSAV A
Sbjct: 440 LGIIPTSDDTGTILGDSFLTNAYVVYDLENLEISMAQARYNTTSENIEIITSSVPSAVKA 499
Query: 503 PGYXXXXXXXXXXXXGGNIF 522
PGY GGNIF
Sbjct: 500 PGYTNTWSTSASIVTGGNIF 519
>YDR144c [O] KOG1339 Aspartyl protease
Length = 596
Score = 405 bits (1041), Expect = e-113
Identities = 225/502 (44%), Positives = 308/502 (60%), Gaps = 32/502 (6%)
Query: 32 ANKKHVFMSFDKLRGNDASEASLSKRRVGHLKKRADGYVDVEIDNQNTFYSVDLEIGTPA 91
+N+ +V M+F K G+ A + L R D Y VE+ NQN+FYSV+L+IGTP
Sbjct: 32 SNEVYVKMNFQKKYGSSFENALDDTKGRTRLMTRDDDYELVELTNQNSFYSVELDIGTPP 91
Query: 92 QKVGVLIDTGSSDLWVPGSGNPFCXXXXXXXXXXX---QDYTALLSSLLSVFGTDVATDY 148
QKV VL+DTGSSDLWV GS NP+C + AL S + SVF T+++ D
Sbjct: 92 QKVTVLVDTGSSDLWVTGSDNPYCSTKKKDTTGSSFKQVNKDALASVVESVF-TEISYD- 149
Query: 149 TYTGIASATGSAGTQTVPTALTSGTVAATSIRSVPSSLATLDCSEFGTFDTSKSSSWQSN 208
T+ T+ + T +T+ S+ +DC+ +GTF+TSKSS++ SN
Sbjct: 150 --------------TTIVTSEATATFDSTA-----STSQLIDCATYGTFNTSKSSTFNSN 190
Query: 209 DTRFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYTDSQFGVLGIGLTGSESTYS 268
+T F I+Y D TFA G WG D++ L+D+N+TGLSFAV+N T+S GVLGIGL G ESTYS
Sbjct: 191 NTEFSIAYGDTTFASGTWGHDQLSLNDLNITGLSFAVANETNSTVGVLGIGLPGLESTYS 250
Query: 269 G-QLSTYNR-YQYDNFPIVLQRNGVIEKNAYSVFLNDLDADSGSILFGAVDHSKYTGTLY 326
G LS+ + Y Y+NFP+VL+ +GVI+ AYS+F ND D+ G+ILFGAVDH KY G LY
Sbjct: 251 GVSLSSVQKSYTYNNFPMVLKNSGVIKSTAYSLFANDSDSKHGTILFGAVDHGKYAGDLY 310
Query: 327 TVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNE---TVTQTKYPALLDTGATFCYFPX 383
T+P++N L+ GY + I+ +TLQG+G + + T+T TK P LLD+G T Y P
Sbjct: 311 TIPIINTLQHRGYKDPIQFQVTLQGLGTSKGDKEDNLTTLTTTKIPVLLDSGTTISYMPT 370
Query: 384 XXXXXXXXXXXXXXXXXXGYYFVDC--DSGSDYDLVFDFGGFHIISPLSDY-IVTTSSSS 440
GYY +DC + + ++FDFGGF++ + LSD+ +VT S S+
Sbjct: 371 ELVKMLADQVGATYSSAYGYYIMDCIKEMEEESSIIFDFGGFYLSNWLSDFQLVTDSRSN 430
Query: 441 QCVLGILPQSDNEITLGDAFLTSAYVVYDLEELEISLAQASYTSGDEKIEVIRDSVPSAV 500
C+LGI PQSD I LGD FL + YVVYDL+ +EIS+AQA+++ E IE+I +VPSA+
Sbjct: 431 ICILGIAPQSDPTIILGDNFLANTYVVYDLDNMEISMAQANFSDDGEYIEIIESAVPSAL 490
Query: 501 AAPGYXXXXXXXXXXXXGGNIF 522
APGY GGN+F
Sbjct: 491 KAPGYSSTWSTYESIVSGGNMF 512
>YLR121c [O] KOG1339 Aspartyl protease
Length = 508
Score = 317 bits (811), Expect = 4e-86
Identities = 161/341 (47%), Positives = 224/341 (65%), Gaps = 6/341 (1%)
Query: 187 ATLDCSEFGTFDTSKSSSWQSNDTR-FYISYADGTFADGDWGVDEIHLDDVNVTGLSFAV 245
+ +DC ++G FD +KSS++++N + FY +Y DGT+A+G +G D++ ++++++GLSFAV
Sbjct: 99 SVMDCDQYGVFDKTKSSTFKANKSSPFYAAYGDGTYAEGAFGQDKLKYNELDLSGLSFAV 158
Query: 246 SNYTDSQFGVLGIGLTGSESTYSGQLSTYNR--YQYDNFPIVLQRNGVIEKNAYSVFLND 303
+N ++S FGVLGIGL+ E TYSG+++ ++ Y+YDNFP+ L+ +G I+ AYS+FLND
Sbjct: 159 ANESNSTFGVLGIGLSTLEVTYSGKVAIMDKRSYEYDNFPLFLKHSGAIDATAYSLFLND 218
Query: 304 LDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNETV 363
SGSILFGAVDHSKY G LYT+P+VN +S GY + +TLQG+G+ + N T+
Sbjct: 219 ESQSSGSILFGAVDHSKYEGQLYTIPLVNLYKSQGYQHPVAFDVTLQGLGLQTDKRNITL 278
Query: 364 TQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSGSD-YDLVFDFGG 422
T TK PALLD+G T Y P GYY C S + + FDFGG
Sbjct: 279 TTTKLPALLDSGTTLTYLPSQAVALLAKSLNASYSKTLGYYEYTCPSSDNKTSVAFDFGG 338
Query: 423 FHIISPLSDYIVTTSSSSQCVLGILPQSDNEIT-LGDAFLTSAYVVYDLEELEISLAQAS 481
F I +PLSD+ + TS + CVL I+PQ+ N LGD+FL +AYVVYDL+ EISLAQA
Sbjct: 339 FRINAPLSDFTMQTSVGT-CVLAIIPQAGNATAILGDSFLRNAYVVYDLDNYEISLAQAK 397
Query: 482 YTSGDEKIEVIRDSVPSAVAAPGYXXXXXXXXXXXXGGNIF 522
Y +G E +EVI+ +VPSA+ AP Y GGNIF
Sbjct: 398 YGTGKENVEVIKSTVPSAIRAPSYNNTWSNYASATSGGNIF 438
Score = 77.0 bits (188), Expect = 7e-14
Identities = 37/81 (45%), Positives = 52/81 (63%), Gaps = 10/81 (12%)
Query: 35 KHVFMSFDKLRGNDASEASLSKRRVGHLKKRADGYVDVEIDNQNTFYSVDLEIGTPAQKV 94
K+V + F K + D G L KR++G+ + N+ +FYSV+L IGTP+Q +
Sbjct: 27 KYVKIPFTKKKNGDN----------GELSKRSNGHEKFVLANEQSFYSVELAIGTPSQNL 76
Query: 95 GVLIDTGSSDLWVPGSGNPFC 115
VL+DTGS+DLWVPG GNP+C
Sbjct: 77 TVLLDTGSADLWVPGKGNPYC 97
>YIR039c [O] KOG1339 Aspartyl protease
Length = 537
Score = 259 bits (662), Expect = 8e-69
Identities = 165/430 (38%), Positives = 234/430 (54%), Gaps = 48/430 (11%)
Query: 81 YSVDLEIGTPAQKVGVLIDTGSSDLWVPGSGNPFCXXXXXXXXXXXQDYTALLSSLLSVF 140
Y V +EIGTP Q + + +DTGSSD+ V + +C
Sbjct: 67 YVVKMEIGTPPQTLYLQLDTGSSDMIVNNADIAYCKSMSD-------------------- 106
Query: 141 GTDVATDYTYTGIASATGSAGTQTVPTALTSGTVAATSIRSVPSSLATLDCSEFGTFDTS 200
G+D A+ Y A+ G L S T+++ + ++ CS +GTFD S
Sbjct: 107 GSDYASTDNYELTATFNG----------LPSTTISSEAYNTL--------CSYWGTFDAS 148
Query: 201 KSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYT-DSQFGVLGIG 259
SS++++N T F +Y DGT+ G +G D + +++ + +F VSN T + G+LGI
Sbjct: 149 NSSTFENNATFFNNTYGDGTYYAGTYGTDVVSFENITLNDFTFGVSNDTIGNPSGILGIS 208
Query: 260 LTGSESTYSGQLS-TYNR--YQYDNFPIVLQRNGVIEKNAYSVFLNDLDADSGSILFGAV 316
L +E T + + NR + YDNFP+ L+ G I K AYS+FLN DA GSILFGAV
Sbjct: 209 LPIAEFTDGIEYALALNRTPFIYDNFPMELKNQGKINKIAYSLFLNGPDAHFGSILFGAV 268
Query: 317 DHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGV-TSSYGNETVTQTKYPALLDTG 375
D SKYTG LYT+PM+ A ++G + IT Q + + S GN+TV+ ++P +LD+G
Sbjct: 269 DKSKYTGQLYTLPMLQAFNTLG--SNPGMIITAQSVAILDSESGNKTVSDIQFPVMLDSG 326
Query: 376 ATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSGSDYDLVFDFGGFHIISPLSDYIVT 435
TF Y P Y DC +D L DFGGF+I + +S+++
Sbjct: 327 TTFSYLPTEIAEAIGKSFDGEYSSDDQGYIFDCSKVNDTLLSVDFGGFNISANISNFV-- 384
Query: 436 TSSSSQCVLGILPQSDNEITLGDAFLTSAYVVYDLEELEISLAQASYTSGDEKIEVIRDS 495
TS+ +CVL + QS++ LGDAFL AYVVYDLE EIS+AQAS+ + +E IEVI D+
Sbjct: 385 TSAKDRCVLNV-KQSESTYMLGDAFLVDAYVVYDLENYEISIAQASFNNQEEDIEVISDT 443
Query: 496 VPSAVAAPGY 505
VP A APGY
Sbjct: 444 VPGATPAPGY 453
>YIL015w [O] KOG1339 Aspartyl protease
Length = 587
Score = 233 bits (593), Expect = 8e-61
Identities = 149/431 (34%), Positives = 220/431 (50%), Gaps = 61/431 (14%)
Query: 77 QNTFYSVDLEIGTPAQKVGVLIDTGSSDLWVPGSGNPFCXXXXXXXXXXXQDYTALLSSL 136
+ +Y+ L+IGTP+Q + VL DTGS+D WV S NPFC
Sbjct: 41 EEMYYATTLDIGTPSQSLTVLFDTGSADFWVMDSSNPFC--------------------- 79
Query: 137 LSVFGTDVATDYTYTGIASATGSAGTQTVPTALTSGTVAATSIRSVPSSLATLDCSEFGT 196
L T ++ TY G + P+ +DC T
Sbjct: 80 LPNSNTSSYSNATYNG---------EEVKPS---------------------IDCRSMST 109
Query: 197 FDTSKSSSWQSNDT-RFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNY-TDSQFG 254
++ +SS++Q + RFYI+YADGTFADG WG + + ++ +++ + F V+ Y T G
Sbjct: 110 YNEHRSSTYQYLENGRFYITYADGTFADGSWGTETVSINGIDIPNIQFGVAKYATTPVSG 169
Query: 255 VLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQRNGVIEKNAYSVFLNDLDADSGSILFG 314
VLGIG ES G N Y Y NFP +L+ +I+ AYS+FLN D+ +GSI+FG
Sbjct: 170 VLGIGFPRRESV-KGYEGAPNEY-YPNFPQILKSEKIIDVVAYSLFLNSPDSGTGSIVFG 227
Query: 315 AVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGV--TSSYGNETVTQTKYPALL 372
A+D SK++G L+T PMVN +I L++T+QG+G SS +ET T TKYP LL
Sbjct: 228 AIDESKFSGDLFTFPMVNEYPTI-VDAPATLAMTIQGLGAQNKSSCEHETFTTTKYPVLL 286
Query: 373 DTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCD-SGSDYDLVFDFGGFHIISPLSD 431
D+G + P G Y +DC S D + FDFG I PLS
Sbjct: 287 DSGTSLLNAPKVIADKMASFVNASYSEEEGIYILDCPVSVGDVEYNFDFGDLQISVPLSS 346
Query: 432 YIVT-TSSSSQCVLGILPQSDNEITLGDAFLTSAYVVYDLEELEISLAQASYTSGDEKIE 490
I++ + S C + P +D+ + LGD FL+SAYVV+DL+ +ISLAQA++ + + +
Sbjct: 347 LILSPETEGSYCGFAVQPTNDS-MVLGDVFLSSAYVVFDLDNYKISLAQANWNASEVSKK 405
Query: 491 VIRDSVPSAVA 501
++ +++
Sbjct: 406 LVNIQTDGSIS 416
>SPAC26A3.01 [O] KOG1339 Aspartyl protease
Length = 514
Score = 92.0 bits (227), Expect = 2e-18
Identities = 97/370 (26%), Positives = 157/370 (42%), Gaps = 41/370 (11%)
Query: 133 LSSLLSVFGTDVATDYTYTGIASATGSAGTQTVPTALTSGTVAATSIRSVPSSLATLDCS 192
L S V+ + T YT + + +A + + + T G A S S + T C+
Sbjct: 82 LGSNERVYSLTLDTGSPYTWVTAKNITALSASEIWSDTDGVDAGRST----SDIRTNACT 137
Query: 193 EFGTFDTSKSSSWQSNDTR--FYISYADGTFADGDWGVDEIHLDDVNVTGLSF--AVSNY 248
+ FD S +++ ++N + F SY D T G VD + + + G F A Y
Sbjct: 138 NYTCFDYSSTTARRTNSSTIGFLASYGDNTTVLGYNMVDNAYFAGLTLPGFEFGLATREY 197
Query: 249 TDSQF----GVLGIGLTGSESTYSGQLSTYNRYQYDNFPIV--LQRNGVIEKNAYSVFLN 302
SQ G++G+ + T +G S + IV L VI+ A+ ++LN
Sbjct: 198 DSSQISVTPGIIGLSVA---MTITGISSDDKVVAFTPPTIVDQLVSANVIDTPAFGIYLN 254
Query: 303 DLDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNET 362
+ D G ++FG D +K G+++ V + ++ S Y S+ L+ I VT+S +
Sbjct: 255 E---DVGELIFGGYDKAKINGSVHWVNISSSDDSTFY------SVNLESITVTNSTSSNN 305
Query: 363 VTQTKYPA---------LLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSGSD 413
V +K + LDTG + Y P GY + CDS SD
Sbjct: 306 VQSSKRSSKDIEVNTTVTLDTGTVYIYLPEDTVESIADQYQGIVSEY-GYVVIYCDSFSD 364
Query: 414 YDLV-FDFGG---FHI-ISPLSDYIVTTSSSSQCVLGILPQSDNEITLGDAFLTSAYVVY 468
D + F+FG FH+ ++ L Y ++S C L + + LG FL Y +Y
Sbjct: 365 SDYISFNFGSDADFHVSVNDLVIYRQESTSGDICYLALFEGDTSSYLLGQYFLQYVYSIY 424
Query: 469 DLEELEISLA 478
D + +I LA
Sbjct: 425 DWDAQKIGLA 434
>YPL154c [O] KOG1339 Aspartyl protease
Length = 405
Score = 86.3 bits (212), Expect = 1e-16
Identities = 84/320 (26%), Positives = 135/320 (41%), Gaps = 53/320 (16%)
Query: 182 VPSS-LATLDCSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNVT- 239
VPS+ +L C +D SSS+++N T F I Y G+ +G D + + D+ +
Sbjct: 117 VPSNECGSLACFLHSKYDHEASSSYKANGTEFAIQYGTGSL-EGYISQDTLSIGDLTIPK 175
Query: 240 ----------GLSFAVSNYTDSQFGVLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQRN 289
GL+FA + G+LG+G + S YN Q D
Sbjct: 176 QDFAEATSEPGLTFAFGKFD----GILGLGYD-TISVDKVVPPFYNAIQQD--------- 221
Query: 290 GVIEKNAYSVFLNDLDADS---GSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLS 346
++++ ++ +L D D+ G FG +D SK+ G + +P+ R Y E
Sbjct: 222 -LLDEKRFAFYLGDTSKDTENGGEATFGGIDESKFKGDITWLPV----RRKAYWE----- 271
Query: 347 ITLQGIGVTSSYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFV 406
+ +GIG+ G+E + A +DTG + P G Y +
Sbjct: 272 VKFEGIGL----GDEYAELESHGAAIDTGTSLITLPSGLAEMINAEIGAKKGWT-GQYTL 326
Query: 407 DCDSGSDY-DLVFDFGGFHIISPLSDYIVTTSSSSQCVLGILPQSDNE-----ITLGDAF 460
DC++ + DL+F+F G++ DY + S S C+ I P E +GDAF
Sbjct: 327 DCNTRDNLPDLIFNFNGYNFTIGPYDYTLEVSGS--CISAITPMDFPEPVGPLAIVGDAF 384
Query: 461 LTSAYVVYDLEELEISLAQA 480
L Y +YDL + LA+A
Sbjct: 385 LRKYYSIYDLGNNAVGLAKA 404
>Hs22063875 [O] KOG1339 Aspartyl protease
Length = 325
Score = 82.8 bits (203), Expect = 1e-15
Identities = 84/342 (24%), Positives = 137/342 (39%), Gaps = 41/342 (11%)
Query: 151 TGIASATGSAGTQTVPTALTSGTVAATSIRSVPSSLA-TLDCSEFGTFDTSKSSSWQSND 209
T I S + + ++ +P S A P S A L + F+ SS++QS
Sbjct: 8 TWIWSTSALSASELLPRISPSSLTPAPPTCGCPQSTAPVLPAANHNRFNPEDSSTYQSTS 67
Query: 210 TRFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYTDSQF-------GVLGIGLTG 262
I+Y G+ G G D + + ++ T F +S F G+LG+
Sbjct: 68 ETVSITYGTGSMT-GILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPS 126
Query: 263 SESTYSGQLSTYNRYQYDNFPIVLQRNGVIEKNAYSVFLNDLDADSGSILFGAVDHSKYT 322
S+ + + +DN + G++ ++ +SV+L+ D ++FG +D S YT
Sbjct: 127 ISSSGATPV-------FDN----IWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYT 175
Query: 323 GTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNETVTQTKYPALLDTGATFCYFP 382
G+L VP+ GY + SIT+ G + + G + A++DTG + P
Sbjct: 176 GSLNWVPVTVE----GYWQITVDSITMNGEAIACAEGCQ--------AIVDTGTSLLTGP 223
Query: 383 XXXXXXXXXXXXXXXXXXXGYYFVDCDSGSDY-DLVFDFGGFHIISPLSDYIVTTSSSSQ 441
G V C + S D+VF G P S YI+ S
Sbjct: 224 -TSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYIL--QSEGS 280
Query: 442 CVLGI----LPQSDNEI-TLGDAFLTSAYVVYDLEELEISLA 478
C+ G LP E+ LGD F+ + V+D ++ LA
Sbjct: 281 CISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLA 322
>Hs22063872 [O] KOG1339 Aspartyl protease
Length = 325
Score = 82.8 bits (203), Expect = 1e-15
Identities = 84/342 (24%), Positives = 137/342 (39%), Gaps = 41/342 (11%)
Query: 151 TGIASATGSAGTQTVPTALTSGTVAATSIRSVPSSLA-TLDCSEFGTFDTSKSSSWQSND 209
T I S + + ++ +P S A P S A L + F+ SS++QS
Sbjct: 8 TWIWSTSALSASELLPRISLSSLTPAPPTCGCPQSTAPVLPAANHNRFNPEDSSTYQSTS 67
Query: 210 TRFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYTDSQF-------GVLGIGLTG 262
I+Y G+ G G D + + ++ T F +S F G+LG+
Sbjct: 68 ETVSITYGTGSMT-GILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPS 126
Query: 263 SESTYSGQLSTYNRYQYDNFPIVLQRNGVIEKNAYSVFLNDLDADSGSILFGAVDHSKYT 322
S+ + + +DN + G++ ++ +SV+L+ D ++FG +D S YT
Sbjct: 127 ISSSGATPV-------FDN----IWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYT 175
Query: 323 GTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNETVTQTKYPALLDTGATFCYFP 382
G+L VP+ GY + SIT+ G + + G + A++DTG + P
Sbjct: 176 GSLNWVPVTVE----GYWQITVDSITMNGEAIACAEGCQ--------AIVDTGTSLLTGP 223
Query: 383 XXXXXXXXXXXXXXXXXXXGYYFVDCDSGSDY-DLVFDFGGFHIISPLSDYIVTTSSSSQ 441
G V C + S D+VF G P S YI+ S
Sbjct: 224 -TSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYIL--QSEGS 280
Query: 442 CVLGI----LPQSDNEI-TLGDAFLTSAYVVYDLEELEISLA 478
C+ G LP E+ LGD F+ + V+D ++ LA
Sbjct: 281 CISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLA 322
>Hs4505757 [O] KOG1339 Aspartyl protease
Length = 388
Score = 81.6 bits (200), Expect = 3e-15
Identities = 81/309 (26%), Positives = 130/309 (41%), Gaps = 47/309 (15%)
Query: 191 CSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVS---- 246
C+ F+ S+SS++ +N F + Y G+ G +G D + + + V F +S
Sbjct: 109 CTSHSRFNPSESSTYSTNGQTFSLQYGSGSLT-GFFGYDTLTVQSIQVPNQEFGLSENEP 167
Query: 247 --NYTDSQF-GVLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQ---RNGVIEKNAYSVF 300
N+ +QF G++G+ Y D +Q + G + +SV+
Sbjct: 168 GTNFVYAQFDGIMGLA--------------YPALSVDEATTAMQGMVQEGALTSPVFSVY 213
Query: 301 LNDLDADSG-SILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYG 359
L++ SG +++FG VD S YTG +Y P+ L QI + L G G S +
Sbjct: 214 LSNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQEL-----YWQIGIEEFLIG-GQASGWC 267
Query: 360 NETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSGSDY-DLVF 418
+E A++DTG + P G + V+C+S + L F
Sbjct: 268 SEGC-----QAIVDTGTSLLTVP-QQYMSALLQATGAQEDEYGQFLVNCNSIQNLPSLTF 321
Query: 419 DFGGFHIISPLSDYIVTTSSSSQCVLGILP-----QSDNEI-TLGDAFLTSAYVVYDLEE 472
G P S YI+ S++ C +G+ P Q+ + LGD FL S Y VYDL
Sbjct: 322 IINGVEFPLPPSSYIL--SNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGN 379
Query: 473 LEISLAQAS 481
+ A A+
Sbjct: 380 NRVGFATAA 388
>SPCC1795.09 [O] KOG1339 Aspartyl protease
Length = 521
Score = 78.6 bits (192), Expect = 3e-14
Identities = 80/326 (24%), Positives = 132/326 (39%), Gaps = 29/326 (8%)
Query: 190 DCSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEI---HLDDVNVTGLSFAVS 246
D FG + S S + ++ + F+I Y D G D + H + +
Sbjct: 130 DSCYFG--NASSSFHFVTSPSTFFIRYDDNITVAGINVQDSLSYSHYQALPDFQFGITLK 187
Query: 247 NYTDSQF----GVLGIGLTGSEST--YSGQLSTYNRYQYDNFPIVLQRNGVIEKNAYSVF 300
Y S GVLG+ + ++ YS +S+++ F L + ++ A+S++
Sbjct: 188 EYVPSSMLPYKGVLGLAASTEINSIDYSDSISSFSP---PTFLEQLVKEDILAYPAFSMY 244
Query: 301 LNDLDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGN 360
L++ +GS+L GAVD SKY G AL+ T ++Q + T
Sbjct: 245 LDN--QGNGSLLLGAVDTSKYQGQFV------ALKQTKLTHYAVSIYSVQFLNSTFFSNY 296
Query: 361 ETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDS-GSDYDLVFD 419
+T A T T+ Y P GY+ ++CD + L+F
Sbjct: 297 SIITD----AYFQTRETYIYLPAELAYSVMDNAGAYLSE--GYFALNCDEIDLEAALIFQ 350
Query: 420 FGGFHIISPLSDYIVTTSSSSQCVLGILPQSDNEITLGDAFLTSAYVVYDLEELEISLAQ 479
FG I +V S+ C+LGI P +D+EI LG F +AY Y + I++ Q
Sbjct: 351 FGCNSTIKVPISLLVIGQVSNICLLGIRPSTDSEIVLGLLFFRNAYTFYHQSQKMIAIGQ 410
Query: 480 ASYTSGDEKIEVIRDSVPSAVAAPGY 505
A Y + ++ +P A+ Y
Sbjct: 411 AFYNATSNLSAIVDQHIPGALTCSQY 436
>7300254 [O] KOG1339 Aspartyl protease
Length = 309
Score = 77.4 bits (189), Expect = 6e-14
Identities = 84/306 (27%), Positives = 123/306 (39%), Gaps = 26/306 (8%)
Query: 177 TSIRSVPSSLATLDCSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDV 236
T + SV ++ C +++S+SSS+ + F + Y G G D +H+
Sbjct: 27 TWLPSVNCPMSNSACQNHRKYNSSRSSSYIPDGRNFTLRYGSGMVV-GYLSKDTMHIAGA 85
Query: 237 NVTGLSFAVSNYTDSQFGVLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQRNGVIEKNA 296
+ +F S + F + G G LS N F +L ++EK
Sbjct: 86 ELPHFTFGESLFLQ-HFAFSSVKFDGLVGLGLGVLSWSNTTP---FLELLCAQRLLEKCV 141
Query: 297 YSVFLNDLDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTS 356
+SV+L D I+FG D SK+ G L+ VP+ S +T +++S S
Sbjct: 142 FSVYLR---RDPREIVFGGFDESKFEGKLHYVPV-----SQWHTWSLQIS--------KS 185
Query: 357 SYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSGSDYDL 416
S G + + K A+LDTG + P GY+ V C SGS ++
Sbjct: 186 SVGTKQIGG-KSNAILDTGTSLVLVPQQTYHNLLNTLSAKLQN--GYFVVACKSGSLPNI 242
Query: 417 VFDFGGFHIISPLSDYI--VTTSSSSQCVLGILPQSDNEITLGDAFLTSAYVVYDLEELE 474
G SDYI V CVL I P + LGD FL Y V+D E
Sbjct: 243 NILIGDKVFPLTSSDYIMEVLLDRKPACVLAIAPINRGFWVLGDIFLRRYYTVFDATEKR 302
Query: 475 ISLAQA 480
I LA+A
Sbjct: 303 IGLAKA 308
>YDR349c [O] KOG1339 Aspartyl protease
Length = 596
Score = 70.9 bits (172), Expect = 5e-12
Identities = 76/307 (24%), Positives = 124/307 (39%), Gaps = 46/307 (14%)
Query: 234 DDVNVTGLSFAVSNYT-----DSQFGVLGI-GLTGSESTYSGQLSTYNRYQYDNFPIVLQ 287
D+V S ++SN + S F G+ GL+G + + + + F +L+
Sbjct: 162 DNVQFNSGSLSISNVSFFDIQSSNFKTSGLLGLSGKVTNPGNAIDSSQYTEQSYFLSLLK 221
Query: 288 RNGVIEKNAYSVFL----------NDLDADSGSILFGAVDHSKYTGTL-------YTVPM 330
+IE ++YS++L D ++ G +L G VD S +TGTL Y P+
Sbjct: 222 DADIIESSSYSLWLAGDTSTYKTYRDPISNCGKLLLGGVDPSLFTGTLGKFDLIPYVDPV 281
Query: 331 VNALRSIGYTEQIRLSITLQGIGVTSSYG---NETVTQTKYPALLDTGATFCYFPXXXXX 387
NA+ S+GY + L I + S+ G N T PALLD+ ++ Y P
Sbjct: 282 SNAV-SVGYP-----IVPLGPIYIVSNSGQSLNMTSKDFLSPALLDSTSSVSYLPTSTII 335
Query: 388 XXXXXXXXXXXXXXGYYFVDCD-SGSDYDLVFDFGGFHIISPLSDYIVTT---------- 436
+ V C + L F I PL D + +T
Sbjct: 336 QIAVQIAATYVESLDRWLVQCSIADMGVSLGFRLRELTIEIPLRDLLSSTYDTSTNSSMF 395
Query: 437 --SSSSQCVLGILPQSDNEIT-LGDAFLTSAYVVYDLEELEISLAQASYTSGDEKIEVIR 493
S C L + ++ + LG+AF+ + Y+ DLE+ I++AQA D E
Sbjct: 396 FSSGQEACFLTLYANTNTGVNILGEAFIKNIYMAMDLEDNTIAIAQAKKVEDDAVTEETN 455
Query: 494 DSVPSAV 500
++ S +
Sbjct: 456 ETTASTI 462
>7290034 [O] KOG1339 Aspartyl protease
Length = 407
Score = 64.7 bits (156), Expect = 4e-10
Identities = 73/315 (23%), Positives = 121/315 (38%), Gaps = 43/315 (13%)
Query: 184 SSLATLDCSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNVTGLSF 243
SS + C + F +KSS++ +N T F I+Y G+ + G VD + + + +F
Sbjct: 106 SSCISTACQDHQVFYKNKSSTYVANGTAFSITYGTGSVS-GYLSVDCVGFAGLTIQSQTF 164
Query: 244 AV------SNYTDSQF-GVLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQRNGVIEKNA 296
+N+ D+ F G+LG+G G T+ + + G+++
Sbjct: 165 GEVTTEQGTNFVDAYFDGILGMGFPSL--AVDGVTPTFQN---------MMQQGLVQSPV 213
Query: 297 YSVFLNDLDADS---GSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIG 353
+S FL D + + G ++ G D S Y+G+L V +V A T+ I+ +G
Sbjct: 214 FSFFLRDNGSVTFYGGELILGGSDPSLYSGSLTYVNVVQAAYWKFQTDYIK-------VG 266
Query: 354 VTSSYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSGSD 413
TS T A+ DTG + P +C S S
Sbjct: 267 STS-------ISTFAQAIADTGTSLIIAPQAQYDQISQLFNANSEG-----LFECSSTSY 314
Query: 414 YDLVFDFGGFHIISPLSDYIVTTSSSSQCVLGILPQSDNEITLGDAFLTSAYVVYDLEEL 473
DL+ + G P YI+ C L I + + +GD FL Y +D+
Sbjct: 315 PDLIININGVDFKIPAKYYII--EEEDFCSLAIQSINQDFWIMGDVFLGRIYTEFDVGNQ 372
Query: 474 EISLAQASYTSGDEK 488
+ A + G K
Sbjct: 373 RLGFAPVNSAVGLRK 387
>7297427 [O] KOG1339 Aspartyl protease
Length = 372
Score = 63.2 bits (152), Expect = 1e-09
Identities = 71/308 (23%), Positives = 119/308 (38%), Gaps = 44/308 (14%)
Query: 182 VPSSLATLD-CSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNVTG 240
VPS+ D C +D+S SS++ +N F I Y G+ G D + ++ +++
Sbjct: 95 VPSNTCKSDACLTHNQYDSSASSTYVANGESFSIQYGTGSLT-GYLSTDTVDVNGLSIQS 153
Query: 241 LSFAVS------NYTDSQF-GVLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQRNGVIE 293
+FA S N+ D+ F G+LG+ S + YN + G+++
Sbjct: 154 QTFAESTNEPGTNFNDANFDGILGMAYE-SLAVDGVAPPFYN----------MVSQGLVD 202
Query: 294 KNAYSVFL--NDLDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQG 351
+ +S +L + G ++FG D S Y+G L VP + GY + ++ G
Sbjct: 203 NSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVP----ISEQGYWQFTMAGSSIDG 258
Query: 352 IGVTSSYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSG 411
+ A+ DTG + P ++DC S
Sbjct: 259 YSLCDD----------CQAIADTGTSLIVAPYNAYITLSEILNVGEDG-----YLDCSSV 303
Query: 412 SDY-DLVFDFGGFHIISPLSDYIVTTSSSSQCVLGILPQSDNEITLGDAFLTSAYVVYDL 470
S D+ F+ GG + + S YI+ S C+ + LGD F+ Y +DL
Sbjct: 304 SSLPDVTFNIGGTNFVLKPSAYII--QSDGNCMSAFEYMGTDFWILGDVFIGQYYTEFDL 361
Query: 471 EELEISLA 478
I A
Sbjct: 362 GNNRIGFA 369
>7296075 [O] KOG1339 Aspartyl protease
Length = 410
Score = 62.8 bits (151), Expect = 1e-09
Identities = 77/316 (24%), Positives = 130/316 (40%), Gaps = 47/316 (14%)
Query: 183 PSSLATLDCSEFGTFDTSKSSSWQSNDTRFYISYA----DGTFA-DGDWGVDEIHLDDVN 237
P S+A C+ +++S S+++++ +T F I+Y +G A G D ++ +
Sbjct: 122 PDSVAP--CANRIKYNSSASTTYRAINTAFNIAYGSNSEEGPIALSGFQSQDTVNFAGYS 179
Query: 238 VTGLSFA-VSNYTDSQF------GVLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQRNG 290
+ FA ++N ++ F G+LG+G S + S YN L G
Sbjct: 180 IKNQIFAEITNAPETAFLKSQLDGILGLGFA-SIAINSITPPFYN----------LMAQG 228
Query: 291 VIEKNAYSVFLNDLDADS---GSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSI 347
++ ++ +S++LN ++ G ++ G D Y+G L VP+ +A GY + S
Sbjct: 229 LVNRSVFSIYLNRNGTNAINGGELILGGSDSGLYSGCLTYVPVSSA----GYWQFTMTSA 284
Query: 348 TLQGIGVTSSYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXX-XXXXGYYFV 406
L G + A+LD G + P G + V
Sbjct: 285 NLNGFQFCENC----------EAILDVGTSLIVVPEQVLDTINQILGVLNPTASNGVFLV 334
Query: 407 DCDSGSDY-DLVFDFGGFHIISPLSDYIVTTSSSSQCVLGILPQSDNEIT-LGDAFLTSA 464
DC S D D+VF SDY++ ++ CV G + N + LG+ FL +
Sbjct: 335 DCSSIGDLPDIVFTVARRKFPLKSSDYVLRYGNT--CVSGFTSMNGNSLLILGEIFLGAY 392
Query: 465 YVVYDLEELEISLAQA 480
Y YD+ I LA A
Sbjct: 393 YTTYDIVYKLIGLAPA 408
>Hs4503145 [O] KOG1339 Aspartyl protease
Length = 396
Score = 61.2 bits (147), Expect = 4e-09
Identities = 81/317 (25%), Positives = 133/317 (41%), Gaps = 44/317 (13%)
Query: 182 VPSSLATLD-CSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNVTG 240
VPS T C F S+SS++ F I Y G+ + G G D++ ++ + V G
Sbjct: 104 VPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLS-GIIGADQVSVEGLTVVG 162
Query: 241 LSFAVS------NYTDSQF-GVLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQRNGVIE 293
F S + D++F G+LG+G S G ++ +DN + +++
Sbjct: 163 QQFGESVTEPGQTFVDAEFDGILGLGYP---SLAVGGVTPV----FDN----MMAQNLVD 211
Query: 294 KNAYSVFLN-DLDADSGS-ILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQG 351
+SV+++ + + +GS ++FG DHS ++G+L VP+ T+Q I L
Sbjct: 212 LPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPV---------TKQAYWQIALDN 262
Query: 352 IGVTSSYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSG 411
I V G A++DTG + P G Y V+C +
Sbjct: 263 IQVG---GTVMFCSEGCQAIVDTGTSLITGP--SDKIKQLQNAIGAAPVDGEYAVECANL 317
Query: 412 SDY-DLVFDFGGF-HIISP----LSDYI--VTTSSSSQCVLGILPQSDNEITLGDAFLTS 463
+ D+ F G + +SP L D++ + SS L I P + LGD F+
Sbjct: 318 NVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQ 377
Query: 464 AYVVYDLEELEISLAQA 480
Y V+D + LA A
Sbjct: 378 FYSVFDRGNNRVGLAPA 394
>7297765 [O] KOG1339 Aspartyl protease
Length = 423
Score = 59.3 bits (142), Expect = 2e-08
Identities = 73/315 (23%), Positives = 127/315 (40%), Gaps = 42/315 (13%)
Query: 179 IRSVPSSLATLDCSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNV 238
+ SV S C + +++S SSS + F I Y G+ + G D + +D + +
Sbjct: 100 VPSVKCSSTNEACQKHNKYNSSASSSHVEDGKGFSIQYGSGSLS-GFLSTDTVDIDGMVI 158
Query: 239 TGLSFAV------SNYTDSQF-GVLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQRNGV 291
+FA S + ++ F G++G+ ++ SG ++T +DN + R G+
Sbjct: 159 RNQTFAEAIDEPGSAFVNTIFDGIIGMAF----ASISGGVTT----PFDN----IIRQGL 206
Query: 292 IEKNAYSVFL--NDLDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITL 349
++ +SV+L + G +++G +D S Y G + VP+ Y + S+ +
Sbjct: 207 VKHPVFSVYLRRDGTSQSGGEVIWGGIDRSIYRGCINYVPVSMP----AYWQFTANSVKI 262
Query: 350 QGIGVTSSYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCD 409
+GI + + A+ DTG + P G FVDC
Sbjct: 263 EGILLCNGC----------QAIADTGTSLIAVPLRAYKAINKVLNATDAGD-GEAFVDCS 311
Query: 410 SGSDYDLV-FDFGGFHIISPLSDYIVTTSSSSQ---CVLGILPQSDNEI-TLGDAFLTSA 464
S V + GG DYI + + C+ G N + LGD FL
Sbjct: 312 SLCRLPNVNLNIGGTTYTLTPKDYIYKVQADNNQTLCLSGFTYLQGNLLWILGDIFLGKV 371
Query: 465 YVVYDLEELEISLAQ 479
Y V+D+ + I A+
Sbjct: 372 YTVFDVGKERIGFAK 386
>7304149 [O] KOG1339 Aspartyl protease
Length = 392
Score = 56.6 bits (135), Expect = 1e-07
Identities = 70/316 (22%), Positives = 113/316 (35%), Gaps = 40/316 (12%)
Query: 182 VPSS---LATLDCSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNV 238
VPS L + C +D SKS ++ N T F I Y G+ + + D V++
Sbjct: 99 VPSKKCHLTNIACLMHNKYDASKSKTYTKNGTEFAIQYGSGSLS------GYLSTDTVSI 152
Query: 239 TGLSFAVSNYTDSQFGVLGIGLTGSESTYSGQLST-YNRYQYDNFP---IVLQRNGVIEK 294
GL + ++ + GL + + G L YN D + G+I
Sbjct: 153 AGLDIKDQTFAEA---LSEPGLVFVAAKFDGILGLGYNSISVDKVKPPFYAMYEQGLISA 209
Query: 295 NAYSVFLN--DLDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGI 352
+S +LN + G I+FG D + YTG +P+ QI++
Sbjct: 210 PVFSFYLNRDPASPEGGEIIFGGSDPNHYTGEFTYLPVTRKA-----YWQIKMD------ 258
Query: 353 GVTSSYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSGS 412
+S G+ + + + DTG + P G Y V CD
Sbjct: 259 --AASIGDLQLCKGGCQVIADTGTSLIAAP-LEEATSINQKIGGTPIIGGQYVVSCDLIP 315
Query: 413 DYDLV-FDFGGFHIISPLSDYIVTTSSSSQCV-------LGILPQSDNEITLGDAFLTSA 464
++ F GG DYI+ + + + L I P + LGD F+
Sbjct: 316 QLPVIKFVLGGKTFELEGKDYILRVAQMGKTICLSGFMGLDIPPPNGPLWILGDVFIGKY 375
Query: 465 YVVYDLEELEISLAQA 480
Y +D+ + A A
Sbjct: 376 YTEFDMGNDRVGFADA 391
>7296076 [O] KOG1339 Aspartyl protease
Length = 405
Score = 56.6 bits (135), Expect = 1e-07
Identities = 77/315 (24%), Positives = 123/315 (38%), Gaps = 49/315 (15%)
Query: 182 VPSS--LAT-LDCSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNV 238
VPS+ LAT + C + +++S SS++ S+ F I Y G+ G +D + ++ + +
Sbjct: 119 VPSAQCLATDVACQQHNQYNSSASSTFVSSGQNFSIQYGTGS-VSGYLAIDTVTINGLAI 177
Query: 239 TGLSF--AVS----NYTDSQF-GVLGIGLTGSESTYSGQLSTYNRYQYDNF--PIV-LQR 288
+F AVS ++TD F G+LG+G Y + DN P L
Sbjct: 178 ANQTFGEAVSQPGASFTDVAFDGILGMG--------------YQQIAEDNVVPPFYNLYE 223
Query: 289 NGVIEKNAYSVFL--NDLDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLS 346
G+I++ + +L N D G + G D + G + P+ GY + +
Sbjct: 224 EGLIDEPVFGFYLARNGSAVDGGQLTLGGTDQNLIAGEMTYTPVTQQ----GYWQFAVNN 279
Query: 347 ITLQGIGVTSSYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFV 406
IT G TV + A+ DTG + P G Y+V
Sbjct: 280 ITWNG----------TVISSGCQAIADTGTSLIAAP--SAAYIQLNNLIGGVPIQGDYYV 327
Query: 407 DCDSGSDYD-LVFDFGGFHIISPLSDYI--VTTSSSSQCVLGILPQSDNEITLGDAFLTS 463
C + S L + GG + P S YI T + + C+ LGD FL
Sbjct: 328 PCSTVSSLPVLTINIGGTNFYLPPSVYIQTYTEGNYTTCMSTFTDIGTGFWILGDVFLGQ 387
Query: 464 AYVVYDLEELEISLA 478
Y +D + + A
Sbjct: 388 YYSEFDFGQNRVGFA 402
>Hs4506475 [O] KOG1339 Aspartyl protease
Length = 406
Score = 56.2 bits (134), Expect = 1e-07
Identities = 86/344 (25%), Positives = 131/344 (38%), Gaps = 47/344 (13%)
Query: 158 GSAGTQTVPTALTSGTVAATSIRSVPSSLAT---LDCSEFGTFDTSKSSSWQSNDTRFYI 214
G G T P +S VPSS + C FD S SSS++ N T +
Sbjct: 88 GEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTL 147
Query: 215 SYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYTDSQF------GVLGIGLTGSESTYS 268
Y+ GT G D I + + VT + V+ F GV+G+G
Sbjct: 148 RYSTGT-VSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFI---EQAI 203
Query: 269 GQLSTYNRYQYDNFPIVLQRNGVIEKNAYSVFLNDLDADS----GSILFGAVDHSKYTGT 324
G+++ +DN I+ Q GV++++ +S + N +S G I+ G D Y G
Sbjct: 204 GRVTPI----FDN--IISQ--GVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGN 255
Query: 325 LYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNETVTQTKYPALLDTGATFCYFPXX 384
+ + ++ G + I ++G+ V SS + + AL+DTGA+ Y
Sbjct: 256 FHYINLIKT----GVWQ-----IQMKGVSVGSS---TLLCEDGCLALVDTGAS--YISGS 301
Query: 385 XXXXXXXXXXXXXXXXXGYYFVDCDSGSDY-DLVFDFGGFHIISPLSDYIVTTSSSSQ-- 441
Y V C+ G D+ F GG +DY+ S SS+
Sbjct: 302 TSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKL 361
Query: 442 CVLG-----ILPQSDNEITLGDAFLTSAYVVYDLEELEISLAQA 480
C L I P + LG F+ Y +D I A A
Sbjct: 362 CTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALA 405
>7300255 [O] KOG1339 Aspartyl protease
Length = 395
Score = 55.1 bits (131), Expect = 3e-07
Identities = 72/317 (22%), Positives = 122/317 (37%), Gaps = 42/317 (13%)
Query: 179 IRSVPSSLATLDCSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNV 238
+ S S ++ C ++ S SS++ + RF I+Y G+ + G D + + + V
Sbjct: 107 VPSAECSPKSVACHHHHRYNASASSTFVPDGRRFSIAYGTGSLS-GRLAQDTVAIGQLVV 165
Query: 239 TGLSFAVSN------YTDSQF-GVLGIGLTGSESTYSGQL--STYNRYQYDN--FPIVLQ 287
+F ++ + D+ F G++G+G L S ++ D F L+
Sbjct: 166 QNQTFGMATHEPGPTFVDTNFAGIVGLGFRPIAELGIKPLFESMCDQQLVDECVFSFYLK 225
Query: 288 RNGVIEKNAYSVFLNDLDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSI 347
RNG K G +LFG VD +K++G+L VP+ +A GY +
Sbjct: 226 RNGSERKG-------------GELLFGGVDKTKFSGSLTYVPLTHA----GYWQ-----F 263
Query: 348 TLQGIGVTSSYGNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVD 407
L I V + N+ A+ DTG + P Y
Sbjct: 264 PLDVIEVAGTRINQ-----NRQAIADTGTSLLAAPPREYLIINSLLGGLPTSNNEYLLNC 318
Query: 408 CDSGSDYDLVFDFGGFHIISPLSDYIVTTSS---SSQCVLGILPQSDNEITLGDAFLTSA 464
+ S ++VF GG DY+++ ++ SS C+ LGD F+
Sbjct: 319 SEIDSLPEIVFIIGGQRFGLQPRDYVMSATNDDGSSICLSAFTLMDAEFWILGDVFIGRY 378
Query: 465 YVVYDLEELEISLAQAS 481
Y +D + I A A+
Sbjct: 379 YTAFDAGQRRIGFAPAA 395
>Hs22063919 [O] KOG1339 Aspartyl protease
Length = 267
Score = 54.7 bits (130), Expect = 4e-07
Identities = 52/182 (28%), Positives = 77/182 (41%), Gaps = 22/182 (12%)
Query: 302 NDLDADSGSI-LFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGN 360
++LD SGS+ +FG +D S YTG+L VP+ GY + SIT+ G + + G
Sbjct: 98 SNLDDQSGSVVIFGGIDSSYYTGSLNWVPVTVE----GYWQITVDSITMNGEAIACAEGC 153
Query: 361 ETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSGSDY-DLVFD 419
+ A++DTG + P G V C + S D+VF
Sbjct: 154 Q--------AIVDTGTSLLTGP-TSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFT 204
Query: 420 FGGFHIISPLSDYIVTTSSSSQCVLGI----LPQSDNEI-TLGDAFLTSAYVVYDLEELE 474
G P S YI+ S C+ G LP E+ LGD F+ + V+D +
Sbjct: 205 INGVQYPVPPSAYIL--QSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQ 262
Query: 475 IS 476
I+
Sbjct: 263 IT 264
>Hs4758754 [O] KOG1339 Aspartyl protease
Length = 420
Score = 53.1 bits (126), Expect = 1e-06
Identities = 84/355 (23%), Positives = 132/355 (36%), Gaps = 53/355 (14%)
Query: 158 GSAGTQTVPTALTSGTVAATSIRSVPSSLA---TLDCSEFGTFDTSKSSSWQSNDTRFYI 214
G G T P T +S VPS ++ C FD SSS+Q+N T+F I
Sbjct: 80 GEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFAI 139
Query: 215 SYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYTDSQF-------GVLGIG--LTGSES 265
Y G DG D++ + + + F + + S G+LG+G + E
Sbjct: 140 QYGTGR-VDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEG 198
Query: 266 TYSGQLSTYNRYQYDNFPIVLQRNGVIEKNAYSVFLN--DLDADSGSILFGAVDHSKYTG 323
R D VL G+++K +S +LN + D G ++ G D + Y
Sbjct: 199 V---------RPPMD----VLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIP 245
Query: 324 TLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNETVTQTKYPALLDTGATFCYFPX 383
L VP+ ++ QI + G G+ T+ A+LDTG + P
Sbjct: 246 PLTFVPV-----TVPAYWQIHMERVKVGPGL-------TLCAKGCAAILDTGTSLITGP- 292
Query: 384 XXXXXXXXXXXXXXXXXXGYYFVDCDSGSDYDLV-FDFGGFHIISPLSDYIVTTSSSS-- 440
G Y + C V F GG DY++ T+ +
Sbjct: 293 TEEIRALHAAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVR 352
Query: 441 QCVLG-----ILPQSDNEITLGDAFLTSAYVVYDLEELE----ISLAQASYTSGD 486
C+ G + P + LGD FL + V+D +++ + LA+A D
Sbjct: 353 LCLSGFQALDVPPPAGPFWILGDVFLGTYVAVFDRGDMKSSARVGLARARTRGAD 407
>Hs4503143 [O] KOG1339 Aspartyl protease
Length = 412
Score = 52.4 bits (124), Expect = 2e-06
Identities = 79/344 (22%), Positives = 132/344 (37%), Gaps = 34/344 (9%)
Query: 158 GSAGTQTVPTALTSGTVAATSIRSVPS---SLATLDCSEFGTFDTSKSSSWQSNDTRFYI 214
G G T P T +S VPS L + C +++ KSS++ N T F I
Sbjct: 81 GEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDI 140
Query: 215 SYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYTDSQ-FG--VLGIGLTGSESTYSGQL 271
Y G+ + G D + + + + S + Q FG G+T + + G L
Sbjct: 141 HYGSGSLS-GYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGIL 199
Query: 272 S-TYNRYQYDN-FPIV--LQRNGVIEKNAYSVFLN-DLDAD-SGSILFGAVDHSKYTGTL 325
Y R +N P+ L + ++++N +S +L+ D DA G ++ G D Y G+L
Sbjct: 200 GMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSL 259
Query: 326 YTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNETVTQTKYPALLDTGATFCYFPXXX 385
+ T + + L + V S T+ + A++DTG + P
Sbjct: 260 ---------SYLNVTRKAYWQVHLDQVEVASGL---TLCKEGCEAIVDTGTSLMVGPVDE 307
Query: 386 XXXXXXXXXXXXXXXXGYYFVDCDSGSDYDLV-FDFGGFHIISPLSDYIVTTSSSSQ--C 442
G Y + C+ S + GG DY + S + + C
Sbjct: 308 VRELQKAIGAVPLIQ-GEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLC 366
Query: 443 VLGIL-----PQSDNEITLGDAFLTSAYVVYDLEELEISLAQAS 481
+ G + P S LGD F+ Y V+D + + A+A+
Sbjct: 367 LSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410
>YGL258w-a [O] KOG1339 Aspartyl protease
Length = 77
Score = 51.6 bits (122), Expect = 3e-06
Identities = 31/72 (43%), Positives = 42/72 (58%), Gaps = 3/72 (4%)
Query: 284 IVLQRNGVIEKN-AYSVFLNDLDADSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQ 342
+ +R G IEK +YS+FLN + GSILFGAVD SKY L T PM A ++
Sbjct: 1 MAFERQGKIEKKISYSLFLNGPNVHFGSILFGAVDKSKYAEELCTHPMRQAYNTL--DSN 58
Query: 343 IRLSITLQGIGV 354
R+ IT+Q + +
Sbjct: 59 SRIIITVQSVAI 70
>CE21681 [O] KOG1339 Aspartyl protease
Length = 396
Score = 51.2 bits (121), Expect = 4e-06
Identities = 67/301 (22%), Positives = 109/301 (35%), Gaps = 43/301 (14%)
Query: 197 FDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYTDSQF--- 253
FDT+KS+++ +F I Y G+ +G G D ++ + V F VS + F
Sbjct: 117 FDTTKSTTFVKETRKFSIQYGSGS-CNGYLGKDVLNFGGLTVQSQEFGVSTHLADVFGYQ 175
Query: 254 ---GVLGIG--LTGSESTYSGQLSTYNRYQYDN--FPIVLQRNGVIEKNAYSVFLNDLDA 306
G+LG+G + + + Q D F + L RN I +
Sbjct: 176 PVDGILGLGWPALAVDQVVPPMQNLIAQKQLDAPLFTVWLDRNLQIAQG----------T 225
Query: 307 DSGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNETVTQT 366
G I +GA+D VN + + Y + LS ++ T ++T
Sbjct: 226 PGGLITYGAID------------TVNCAKQVTY---VPLSAKTYWQFPLDAFAVGTYSET 270
Query: 367 KYPALL-DTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDS-GSDYDLVFDFGGFH 424
K ++ DTG ++ P Y VDC + + DL+F GG
Sbjct: 271 KKDQVISDTGTSWLGAPNTIVSAIVKQTKAVFDWSTELYTVDCSTMKTQPDLIFTIGGAQ 330
Query: 425 IISPLSDYIVTTS-SSSQCVLGILPQSDNEI----TLGDAFLTSAYVVYDLEELEISLAQ 479
+Y++ +C L + LGD F+ VYD+ +I A
Sbjct: 331 FPVKSVEYVLDLQLGGGKCALAVFSMGSGGFGPSWILGDTFIRQYCNVYDIGNGQIGFAT 390
Query: 480 A 480
A
Sbjct: 391 A 391
>7300253 [O] KOG1339 Aspartyl protease
Length = 465
Score = 51.2 bits (121), Expect = 4e-06
Identities = 66/309 (21%), Positives = 117/309 (37%), Gaps = 44/309 (14%)
Query: 191 CSEFGTFDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVSN--- 247
C + + +KSS++ N F I+Y G+ A G D + + + VT +FA++
Sbjct: 186 CKKHKQYHPAKSSTYVKNGKSFAITYGSGSVA-GVLAKDTVRIAGLVVTNQTFAMTTKEP 244
Query: 248 ---YTDSQF-GVLGIGLTGSESTYSGQLSTYNRYQYDNFPIVLQR---NGVIEKNAYSVF 300
+ S F G+LG+G Y DN ++Q VI +++
Sbjct: 245 GTTFVTSNFDGILGLG--------------YRSIAVDNVKTLVQNMCSEDVITSCKFAIC 290
Query: 301 LNDLDADS--GSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSY 358
+ + S G+I+FG+ + S Y+G+ N+ T++ TLQ I Y
Sbjct: 291 MKGGGSSSRGGAIIFGSSNTSAYSGS-------NSYTYTPVTKKGYWQFTLQDI-----Y 338
Query: 359 GNETVTQTKYPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDSGSDYDLVF 418
T A++D+G + P G ++ C D F
Sbjct: 339 VGGTKVSGSVQAIVDSGTSLITAPTAIYNKINKVIGCRATSS-GECWMKCAKKIP-DFTF 396
Query: 419 DFGGFHII---SPLSDYIVTTSSSSQCVLGILPQSDNEITLGDAFLTSAYVVYDLEELEI 475
G + + + + T + C+ + D + LGDAF+ +DL I
Sbjct: 397 VIAGKKFVVKGNKMKLKVRTNRGRTVCISAVTEVPDEPVILGDAFIRHFCTEFDLANNRI 456
Query: 476 SLAQASYTS 484
A +Y++
Sbjct: 457 GFAATTYST 465
>CE20430 [O] KOG1339 Aspartyl protease
Length = 638
Score = 50.8 bits (120), Expect = 6e-06
Identities = 65/299 (21%), Positives = 112/299 (36%), Gaps = 38/299 (12%)
Query: 197 FDTSKSSSWQSNDTRFYISYADGTFADGDWGVDEIHLDDVNVTGLSFAVSNYTDSQFGVL 256
F+T+KS+S+ ++ +F I Y G G G D + + + + F V+N D FG
Sbjct: 110 FNTTKSTSFVKSNRKFNIQYGSGE-CSGYLGTDTVEIGGLKIQKQEFGVANIVDYDFGTR 168
Query: 257 GI-GLTGSESTYSGQLSTYNRYQYDNFPIVLQR---NGVIEKNAYSVFLNDLDAD----- 307
I G+ G + D +Q ++ +++F + D D
Sbjct: 169 PIDGIFG---------LAWPALSVDQVTPPMQNLVSQNQLDAPIFTIFFDKRDPDYYYPS 219
Query: 308 SGSILFGAVDHSKYTGTLYTVPMVNALRSIGYTEQIRLSITLQGIGVTSSYGNETVTQTK 367
+G I +G +D + VP+ + + + G V G T +
Sbjct: 220 NGLITYGGLDTKNCNANISYVPV---------SSKTYWQFKVDGFQV----GTYNRTVNR 266
Query: 368 YPALLDTGATFCYFPXXXXXXXXXXXXXXXXXXXGYYFVDCDS-GSDYDLVFDFGG--FH 424
A++DTG+++ P Y V C + S DLVF G F
Sbjct: 267 DQAIMDTGSSWFGLPYSVIAGIATQTNATWDLYASVYTVPCSTMNSLPDLVFTIGAEKFP 326
Query: 425 IISP--LSDYIVTTSSSSQCVLGILPQS-DNEITLGDAFLTSAYVVYDLEELEISLAQA 480
I +P + D + + + + GI +TLG+ F+ V+D+ I A A
Sbjct: 327 ISAPEYVEDVGLDDGTCALAMYGIDASGFGPSVTLGNIFIRRYCSVFDVGNARIGFADA 385
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,685,970
Number of Sequences: 60738
Number of extensions: 1167722
Number of successful extensions: 2940
Number of sequences better than 1.0e-05: 29
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 2874
Number of HSP's gapped (non-prelim): 55
length of query: 589
length of database: 30,389,216
effective HSP length: 112
effective length of query: 477
effective length of database: 23,586,560
effective search space: 11250789120
effective search space used: 11250789120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)