ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1127 good K KOG2150 Transcription CCR4-NOT transcriptional regulation complex, NOT5 subunit
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1127 391816 394089 758
(758 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIL038c [K] KOG2150 CCR4-NOT transcriptional regulation complex ... 553 e-157
SPAC1B3.05 [K] KOG2150 CCR4-NOT transcriptional regulation compl... 181 3e-45
Hs7657387 [K] KOG2150 CCR4-NOT transcriptional regulation comple... 180 8e-45
7302229 [K] KOG2150 CCR4-NOT transcriptional regulation complex ... 175 2e-43
At5g18230 [K] KOG2150 CCR4-NOT transcriptional regulation comple... 165 2e-40
YPR072w [K] KOG2150 CCR4-NOT transcriptional regulation complex ... 164 4e-40
CE22572 [K] KOG2150 CCR4-NOT transcriptional regulation complex ... 157 6e-38
Hs5453642 [D] KOG0018 Structural maintenance of chromosome prote... 54 7e-07
Hs14764231 [D] KOG0018 Structural maintenance of chromosome prot... 54 7e-07
>YIL038c [K] KOG2150 CCR4-NOT transcriptional regulation complex NOT5
subunit
Length = 836
Score = 553 bits (1425), Expect = e-157
Identities = 345/870 (39%), Positives = 479/870 (54%), Gaps = 151/870 (17%)
Query: 1 MAHRKLQQEIDRVFKKVNEGLEIFDMYYERHENCVNNPSQKDKLESDLKREVKKLQRLRE 60
MAHRKLQQE+DRVFKK+NEGLEIF+ YYERHE+C NNPSQKDKLESDLKREVKKLQRLRE
Sbjct: 1 MAHRKLQQEVDRVFKKINEGLEIFNSYYERHESCTNNPSQKDKLESDLKREVKKLQRLRE 60
Query: 61 QIKSWQSSPEVKDKDSLLNHRRSVEVAMEKYKAVEKASKEKAYSNISLKRSDVLDPLEKE 120
QIKSWQSSP++KDKDSLL++RRSVE+AMEKYKAVEKASKEKAYSNISLK+S+ LDP E+E
Sbjct: 61 QIKSWQSSPDIKDKDSLLDYRRSVEIAMEKYKAVEKASKEKAYSNISLKKSETLDPQERE 120
Query: 121 RRDVEEFLSNQIEELERQFDLLQIDVDRLILLQKKRKTATPENEKELQRFKDLQGRYRYH 180
RRD+ E+LS I+ELERQ+D LQ+++D+L+LL KK+KT++ N+++ +++K Q RYR+H
Sbjct: 121 RRDISEYLSQMIDELERQYDSLQVEIDKLLLLNKKKKTSSTTNDEKKEQYKRFQARYRWH 180
Query: 181 QQQMELALRLIANEELEPQQVRDIEEEILFYVEENQTEGFVEDDSIYEGLDLQSNEX-XX 239
QQQMELALRL+ANEEL+PQ V++++++I ++VE NQ FVED++IY+GL+LQSNE
Sbjct: 181 QQQMELALRLLANEELDPQDVKNVQDDINYFVESNQDPDFVEDETIYDGLNLQSNEAIAH 240
Query: 240 XXXXXXXXXXXXXXXSGDDNESKD--GKLSKKELRRLEREXXXXXXXXXXXXX------- 290
+ D NES KLSKKE R+LERE
Sbjct: 241 EVAQYFASQNAEDNNTSDANESLQDISKLSKKEQRKLEREAKKAAKLAAKNATGAAIPVA 300
Query: 291 -LDENPTPVITGKKLPDLANEMQEADSQDXXXXXXXXXXXXXXXXXXXXXXXAGSANVPL 349
P+PVI + D + E + + S S P
Sbjct: 301 GPSSTPSPVI---PVADASKETERSPSSSPIHNATKPEEAVKT-----------SIKSPR 346
Query: 350 TTANTTAPSKPHTPLAKSAHLSSNPTSQASLSPDSQPHGFTHIHQSLNGLT-TTTLKPA- 407
++A+ PS +P +S +P++ + THIHQ+ NG+T TTLKPA
Sbjct: 347 SSADNLLPSLQKSP--------------SSATPETPTNVHTHIHQTPNGITGATTLKPAT 392
Query: 408 -PVKPISENKWXXXXXXXXXXXXXXXXXXXPVTTKVSLTPTNM----------------- 449
P KP E KW ++ + TPT
Sbjct: 393 LPAKPAGELKWAVAASQAVEKDRKVTSASSTISNTSTKTPTTAAATTTSSNANSRIGSAL 452
Query: 450 -LPGASTVALPM-----------------------------------VSKPLEPTLSISN 473
P ST +L + +S P +S++
Sbjct: 453 NTPKLSTSSLSLQPDNTGASSSAATAAAVLAAGAAAVHQNNQAFYRNMSSSHHPLVSLAT 512
Query: 474 SIKIIPQELQGNNTVKQHTGDATEPDLILDDYDAESTDD----------------ELENE 517
+ K E + TV Q+ G +++ + ES ++ E + +
Sbjct: 513 NPK---SEHEVATTVNQN-GPENTTKKVMEQKEEESPEERNKLQVPTFGVFDDDFESDRD 568
Query: 518 PTPEIFTAEQISSRLTLSNEVQDSLYSDL--------ELLTLPAGIKDFVMGSVISKNKL 569
E EQ S+ LS E +++ +++ E L LP+G+++F+M S + +++
Sbjct: 569 SETEPEEEEQPSTPKYLSLEQREAKTNEIKKEFVSDFETLLLPSGVQEFIMSSELYNSQI 628
Query: 570 YPNDGKLGGYRRYYDICQPCRLNEIPSGVFPPQPLDVARCTQQWDQVILSLNIDGLTVET 629
+ K+ Y+R D+C+ RL E+P GV PP PLD R TQQWD + SL + E
Sbjct: 629 ---ESKI-TYKRSRDMCEISRLVEVPQGVNPPSPLDAFRSTQQWDVMRCSLRDIIIGSER 684
Query: 630 VPKE-----------FENLETFTLFYHYYFSVTPLEQRICALLLKQREWRVLKTGDCWFL 678
+ ++ F LE F+LFY+YYF++TPLE+ I +L +R+W+V K G WFL
Sbjct: 685 LKEDSSSIYAKILENFRTLEMFSLFYNYYFAITPLEREIAYKILNERDWKVSKDGTMWFL 744
Query: 679 RQGAVKFSNDQCEVADYKIFKMDIWTVVDKLNFKLDYSLL-------ADVASLGQVDHAD 731
RQG VKF N+ CEV DYKIFK+D WTV+DK+NF+LDYS L ++V + ++
Sbjct: 745 RQGEVKFFNEICEVGDYKIFKLDDWTVIDKINFRLDYSFLQPPVDTASEVRDVSVDNNNV 804
Query: 732 HADSSVNLP------TFGKQLLQTLKHGKV 755
+ S+V L + GKQLL+ LK GK+
Sbjct: 805 NDQSNVTLEQQKQEISHGKQLLKQLKQGKI 834
>SPAC1B3.05 [K] KOG2150 CCR4-NOT transcriptional regulation complex NOT5
subunit
Length = 630
Score = 181 bits (460), Expect = 3e-45
Identities = 93/217 (42%), Positives = 150/217 (68%), Gaps = 8/217 (3%)
Query: 19 EGLEIFDMYYERHENCVNNPSQKDKLESDLKREVKKLQRLREQIKSWQSSPEVKDKDSLL 78
E + IFD YE+ + N+ SQK+KLE DLK ++KKLQRLR+QIK+W SS ++KDK +LL
Sbjct: 9 EKIAIFDEVYEKL-SASNSVSQKEKLEGDLKTQIKKLQRLRDQIKTWASSNDIKDKKALL 67
Query: 79 NHRRSVEVAMEKYKAVEKASKEKAYSNISLKRSDVLDPLEKERRDVEEFLSNQIEELERQ 138
+RR +E ME++KAVE+ K KA+S L + LDP EKE++D +++SN +EELERQ
Sbjct: 68 ENRRLIEAKMEEFKAVEREMKIKAFSKEGLSIASKLDPKEKEKQDTIQWISNAVEELERQ 127
Query: 139 FDLLQIDVDRLILLQKKRKTATPENEKELQRFKDLQG---RYRYHQQQMELALRLIANEE 195
+L++ + + L K+ K ++ +L +L+ R+++HQ ++EL +R + N +
Sbjct: 128 AELIEAEAESLKATFKRGK----KDLSKLSHLSELESRIERHKWHQDKLELIMRRLENSQ 183
Query: 196 LEPQQVRDIEEEILFYVEENQTEGFVEDDSIYEGLDL 232
+ P+ V DI+E+I++YVE +Q+E F ED+++Y+ L+L
Sbjct: 184 ISPEAVNDIQEDIMYYVECSQSEDFAEDENLYDELNL 220
>Hs7657387 [K] KOG2150 CCR4-NOT transcriptional regulation complex NOT5
subunit
Length = 753
Score = 180 bits (456), Expect = 8e-45
Identities = 89/230 (38%), Positives = 153/230 (65%), Gaps = 2/230 (0%)
Query: 4 RKLQQEIDRVFKKVNEGLEIFDMYYERHENCVNNPSQKDKLESDLKREVKKLQRLREQIK 63
RKLQ EIDR KKV+EG+E F+ +++ N N +QK+K E+DLK+E+KKLQRLR+QIK
Sbjct: 5 RKLQGEIDRCLKKVSEGVEQFEDIWQKLHNAAN-ANQKEKYEADLKKEIKKLQRLRDQIK 63
Query: 64 SWQSSPEVKDKDSLLNHRRSVEVAMEKYKAVEKASKEKAYSNISLKRSDVLDPLEKERRD 123
+W +S E+KDK L+++R+ +E ME++K VE+ +K KAYS L + +DP +KE+ +
Sbjct: 64 TWVASNEIKDKRQLIDNRKLIETQMERFKVVERETKTKAYSKEGLGLAQKVDPAQKEKEE 123
Query: 124 VEEFLSNQIEELERQFDLLQIDVDRLILLQKKRKTATPENEKELQRFKDLQGRYRYHQQQ 183
V ++L+N I+ L Q D + +V+ L +Q ++K + + ++ K ++RYH +
Sbjct: 124 VGQWLTNTIDTLNMQVDQFESEVESL-SVQTRKKKGDKDKQDRIEGLKRHIEKHRYHVRM 182
Query: 184 MELALRLIANEELEPQQVRDIEEEILFYVEENQTEGFVEDDSIYEGLDLQ 233
+E LR++ N+ + +R I++++ +YV+ +Q F E++ +Y+ LDL+
Sbjct: 183 LETILRMLDNDSILVDAIRKIKDDVEYYVDSSQDPDFEENEFLYDDLDLE 232
>7302229 [K] KOG2150 CCR4-NOT transcriptional regulation complex NOT5
subunit
Length = 948
Score = 175 bits (444), Expect = 2e-43
Identities = 98/240 (40%), Positives = 156/240 (64%), Gaps = 15/240 (6%)
Query: 2 AHRKLQQEIDRVFKKVNEGLEIFDMYYERHENCVN-NPSQK---DKLESDLKREVKKLQR 57
A RKLQ EIDR KKV EG+E F+ +++ N N N QK +K E+DLK+E+KKLQR
Sbjct: 3 ATRKLQGEIDRCLKKVAEGVETFEDIWKKVHNATNTNQKQKHLQEKYEADLKKEIKKLQR 62
Query: 58 LREQIKSWQSSPEVKDKDSLLNHRRSVEVAMEKYKAVEKASKEKAYSNISLKRSDVLDPL 117
LR+QIKSW +S E+KDK SLL +RR +E ME++K VE+ +K KAYS L + +DP
Sbjct: 63 LRDQIKSWIASAEIKDKSSLLENRRLIETQMERFKVVERETKTKAYSKEGLGAAQKMDPA 122
Query: 118 EKERRDVEEFLSNQIEELERQFDLLQIDVDRLILLQKKRKTATPENEKELQRFKDLQG-- 175
++ + D +L++ I L+ Q D + +++ L+ +KKR + +K+ +R DL+G
Sbjct: 123 QRIKDDARNWLTSSISSLQIQIDQYESEIESLLAGKKKRL----DRDKQ-ERMDDLRGKL 177
Query: 176 -RYRYHQQQMELALRLIANEELEPQQVRDIEEEILFYVEENQTEGFVEDDSIYE---GLD 231
R+++H ++E LRL+ N+ +E +QV I++++ +Y++ +Q F E++ IY+ GLD
Sbjct: 178 DRHKFHITKLETLLRLLDNDGVEAEQVNKIKDDVEYYIDSSQEPDFEENEFIYDDIIGLD 237
>At5g18230 [K] KOG2150 CCR4-NOT transcriptional regulation complex NOT5
subunit
Length = 889
Score = 165 bits (418), Expect = 2e-40
Identities = 98/244 (40%), Positives = 148/244 (60%), Gaps = 16/244 (6%)
Query: 2 AHRKLQQEIDRVFKKVNEGLEIFDMYYERHENCVNNPSQKDKLESDLKREVKKLQRLREQ 61
A RKLQ EIDRV KKV EG+++FD + + + +N +QK+K E+DLK+E+KKLQR R+Q
Sbjct: 3 ASRKLQGEIDRVLKKVQEGVDVFDSIWNKVYD-TDNVNQKEKFEADLKKEIKKLQRYRDQ 61
Query: 62 IKSWQSSPEVKDK-------DSLLNHRRSVEVAMEKYKAVEKASKEKAYSNISLKRSDVL 114
IK+W S E+KDK SL++ R+ +E ME++K EK +K KA+S L +
Sbjct: 62 IKTWIQSSEIKDKKVSASYEQSLVDARKLIEKEMERFKICEKETKTKAFSKEGLGQQPKT 121
Query: 115 DPLEKERRDVEEFLSNQIEELERQFDLLQIDVDRLILLQKKRKTATPENEKELQRFKDLQ 174
DP EK + + ++L+N + ELE Q D + +++ L + KK KT P L +
Sbjct: 122 DPKEKAKSETRDWLNNVVSELESQIDSFEAELEGLSV--KKGKTRPP----RLTHLETSI 175
Query: 175 GRYRYHQQQMELALRLIANEELEPQQVRDIEEEILFYVEENQT--EGFVEDDSIYEGLDL 232
R++ H ++EL LRL+ N+EL P+QV D+++ + YVE NQ + F + D +Y L L
Sbjct: 176 TRHKDHIIKLELILRLLDNDELSPEQVNDVKDFLDDYVERNQDDFDEFSDVDELYSTLPL 235
Query: 233 QSNE 236
E
Sbjct: 236 DEVE 239
>YPR072w [K] KOG2150 CCR4-NOT transcriptional regulation complex NOT5
subunit
Length = 560
Score = 164 bits (416), Expect = 4e-40
Identities = 104/324 (32%), Positives = 172/324 (52%), Gaps = 31/324 (9%)
Query: 1 MAHRKLQQEIDRVFKKVNEGLEIFDMYYERHENC-VNNPSQKDKLESDLKREVKKLQRLR 59
M+ RKLQQ+ID++ KKV EG+E FD YE+ ++ +N S ++KLESDLKRE+KKLQ+ R
Sbjct: 1 MSQRKLQQDIDKLLKKVKEGIEDFDDIYEKFQSTDPSNSSHREKLESDLKREIKKLQKHR 60
Query: 60 EQIKSWQSSPEVKDKDS-LLNHRRSVEVAMEKYKAVEKASKEKAYSNISLKRSDVL-DPL 117
+QIK+W S +VKDK S L+ +RR +E ME++K+VEK K K +S +L D++ DP
Sbjct: 61 DQIKTWLSKEDVKDKQSVLMTNRRLIENGMERFKSVEKLMKTKQFSKEALTNPDIIKDPK 120
Query: 118 EKERRDVEEFLSNQIEELERQFDLLQIDVDRLILLQKKRKTATPENEKELQRFKDLQGRY 177
E ++RD F+ + ++EL++Q + + ENE++ + R+
Sbjct: 121 ELKKRDQVLFIHDCLDELQKQLEQYE----------------AQENEEQTE-------RH 157
Query: 178 RYHQQQMELALRLIANEELEPQQVRDIEEEILFYVEENQTEGFVEDDSIYE--GLDLQ-- 233
+H +E L+ + N E++P+ V + +++I +YVE N F+E D+IYE G ++Q
Sbjct: 158 EFHIANLENILKKLQNNEMDPEPVEEFQDDIKYYVENNDDPDFIEYDTIYEDMGCEIQPS 217
Query: 234 SNEXXXXXXXXXXXXXXXXXXSGDDNESKDGKLSKKELRRLEREXX-XXXXXXXXXXXLD 292
S+ S S K ++++ +R +
Sbjct: 218 SSNNEAPKEGNNQTSLSSIRSSKKQERSPKKKAPQRDVSISDRATTPIAPGVESASQSIS 277
Query: 293 ENPTPVITGKKLPDLANEMQEADS 316
PTPV T L + ++ + D+
Sbjct: 278 STPTPVSTDTPLHTVKDDSIKFDN 301
>CE22572 [K] KOG2150 CCR4-NOT transcriptional regulation complex NOT5
subunit
Length = 513
Score = 157 bits (397), Expect = 6e-38
Identities = 88/245 (35%), Positives = 150/245 (60%), Gaps = 17/245 (6%)
Query: 4 RKLQQEIDRVFKKVNEGLEIFDMYYER-HENCVNNPSQKDKLESDLKREVKKLQRLREQI 62
RKL EID+ FKK++EG+E+F+ E+ HE N+ +Q+DK + DLK+E+KKLQRLR+Q+
Sbjct: 5 RKLLAEIDKCFKKIDEGVELFEETMEKMHE--ANSDNQRDKYQDDLKKEIKKLQRLRDQV 62
Query: 63 KSWQSSPEVKDKDSLLNHRRSVEVAMEKYKAVEKASKEKAYSNISLKRSDVLDPLEKERR 122
K+WQ++ E+KDKD L ++R+ +E ME++K VE+ +K K +S + L + LDP EKE+
Sbjct: 63 KNWQNASEIKDKDKLNSYRKLIEQRMEQFKDVERENKTKPHSKLGLSAEEKLDPKEKEKA 122
Query: 123 DVEEFLSNQIEELERQFDLLQIDVDRLILLQ-------KKRKTATP-ENEKELQRFKDLQ 174
+ +++ +QI L + D ++ ++ L KK T E EK ++ K
Sbjct: 123 ETMDWIQHQIRSLNEEVDRTEMQLESLSNTDTGKGKRGKKEDAKTKNEREKRVEGLKHHL 182
Query: 175 GRYRYHQQQMELALRLIANEELEPQQVRD-IEEEILFYV-----EENQTEGFVEDDSIYE 228
R +H +++E+ +R+I+NE L + V + ++E I YV E+++ + D Y+
Sbjct: 183 ERINFHIEKLEICMRMISNESLNAKMVLETLKEPIETYVEMMNEEDSEEADNYDPDDAYD 242
Query: 229 GLDLQ 233
L+L+
Sbjct: 243 ELNLE 247
>Hs5453642 [D] KOG0018 Structural maintenance of chromosome protein 1 (sister
chromatid cohesion complex Cohesin subunit SMC1)
Length = 1233
Score = 54.3 bits (129), Expect = 7e-07
Identities = 60/229 (26%), Positives = 111/229 (48%), Gaps = 32/229 (13%)
Query: 3 HRKLQQEIDR------VFKKVNEGLEIFDMYYE---RHENCVNNPSQKDKLESDLKREVK 53
+++L+ E+ R +FK + +EI + E +++ + + DK+E +LK + K
Sbjct: 209 YQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK 268
Query: 54 KL-QRLREQIKSWQSSPEVKDKDSLLNHRR-----SVEVAMEKYKAVEKASK--EKAYSN 105
+L + +REQ Q E+K+KDS LN +R + E K K +E A K + A +
Sbjct: 269 ELGKMMREQ---QQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 325
Query: 106 ISLKRSDVLDPLEKE-------RRDVEEFLSNQIEELERQFDLLQIDVDRLILLQKKRKT 158
++ D +D LEKE R++ EE + + + R L + V + L+++
Sbjct: 326 YKKRKGD-MDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASK 384
Query: 159 ATPENEKELQRFKDLQGRYRYHQQQMELALR-LIANEELEPQQVRDIEE 206
+EL++F Q + Q +++L R + E Q++R+IEE
Sbjct: 385 RAATLAQELEKFNRDQ---KADQDRLDLEERKKVETEAKIKQKLREIEE 430
>Hs14764231 [D] KOG0018 Structural maintenance of chromosome protein 1 (sister
chromatid cohesion complex Cohesin subunit SMC1)
Length = 1233
Score = 54.3 bits (129), Expect = 7e-07
Identities = 60/229 (26%), Positives = 111/229 (48%), Gaps = 32/229 (13%)
Query: 3 HRKLQQEIDR------VFKKVNEGLEIFDMYYE---RHENCVNNPSQKDKLESDLKREVK 53
+++L+ E+ R +FK + +EI + E +++ + + DK+E +LK + K
Sbjct: 209 YQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKK 268
Query: 54 KL-QRLREQIKSWQSSPEVKDKDSLLNHRR-----SVEVAMEKYKAVEKASK--EKAYSN 105
+L + +REQ Q E+K+KDS LN +R + E K K +E A K + A +
Sbjct: 269 ELGKMMREQ---QQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 325
Query: 106 ISLKRSDVLDPLEKE-------RRDVEEFLSNQIEELERQFDLLQIDVDRLILLQKKRKT 158
++ D +D LEKE R++ EE + + + R L + V + L+++
Sbjct: 326 YKKRKGD-MDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASK 384
Query: 159 ATPENEKELQRFKDLQGRYRYHQQQMELALR-LIANEELEPQQVRDIEE 206
+EL++F Q + Q +++L R + E Q++R+IEE
Sbjct: 385 RAATLAQELEKFNRDQ---KADQDRLDLEERKKVETEAKIKQKLREIEE 430
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.313 0.132 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,989,572
Number of Sequences: 60738
Number of extensions: 1849412
Number of successful extensions: 6888
Number of sequences better than 1.0e-05: 9
Number of HSP's better than 0.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 6848
Number of HSP's gapped (non-prelim): 17
length of query: 758
length of database: 30,389,216
effective HSP length: 114
effective length of query: 644
effective length of database: 23,465,084
effective search space: 15111514096
effective search space used: 15111514096
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)