ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1240 good R KOG2552 General function prediction only Major facilitator superfamily permease - Cdc91p
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1240 436221 437396 392
(392 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR459w [R] KOG2552 Major facilitator superfamily permease - Cdc91p 437 e-122
Hs17998700 [R] KOG2552 Major facilitator superfamily permease - ... 161 1e-39
7297430 [R] KOG2552 Major facilitator superfamily permease - Cdc91p 138 2e-32
At1g12730 [R] KOG2552 Major facilitator superfamily permease - C... 114 2e-25
CE06491 [R] KOG2552 Major facilitator superfamily permease - Cdc91p 65 2e-10
SPAC1952.01 [R] KOG2552 Major facilitator superfamily permease -... 53 9e-07
>YLR459w [R] KOG2552 Major facilitator superfamily permease - Cdc91p
Length = 394
Score = 437 bits (1124), Expect = e-122
Identities = 219/398 (55%), Positives = 296/398 (74%), Gaps = 10/398 (2%)
Query: 1 MVSSEWQVVWACFASRLAVSYLFPSLQQQLDRTVEFSTPVTSYRSLQEGAYLLLHNLPIY 60
M S+ +V C A RLAV+ LFPSLQQQLD++VEFSTPVTS+RSLQEG YLL +N+ +Y
Sbjct: 1 MDSTALKVALGCIAIRLAVNSLFPSLQQQLDQSVEFSTPVTSFRSLQEGIYLLRNNIQVY 60
Query: 61 DGGVVHHVPLLVALMAFVQQAEFLMPVLFAAMDTLIAYQLMQIAKIYQRQLQIPSYIPGV 120
+ GVVHH P+L+ ++ ++ L+ +++A +D LIAYQL ++ K + + L++ ++PG+
Sbjct: 61 NHGVVHHPPILIFFLSLFN-SDRLISLIYALIDGLIAYQLTEVTKAF-KNLKLKVWLPGL 118
Query: 121 VYAVNPLVLLSCVSQSTCLFVNLSISTSLLFALSR-QFSLSAICIALAGYLSPYAYLLLI 179
+YAVNPL LLSC+S+S+ +F N +IS+SL L+ LS++ I+++GYLS Y LLLI
Sbjct: 119 LYAVNPLTLLSCISRSSIIFTNFAISSSLYCILAEGNVLLSSVMISISGYLSVYPILLLI 178
Query: 180 PLAGICGSNSFGLVVKCTLVSI----VLQLISFK-LNNDNWNYLTSTYWILITFSKIRPN 234
PL G+ S+ + +VSI +L L S+ L + +W++LT Y +ITF K+ PN
Sbjct: 179 PLLGML--KSWRQRILSAIVSILSLLILLLFSYSILGSQSWSFLTQVYGSIITFEKVFPN 236
Query: 235 LGLWWYXXXXXXXXXXXXXKSVFNIFVVSFIPPFTIRFNQQSFYAFVLCLGWITLTKSYP 294
LGLWWY K+VFNIF+ FI PFT+R+++Q FYAF+LC+GWI LTK YP
Sbjct: 237 LGLWWYFFIEMFDTFIPFFKAVFNIFIAVFITPFTLRYHKQPFYAFILCIGWIVLTKPYP 296
Query: 295 TLGDGGFFLSFIPFFKPIFGYLRYPVISTLLFIHAIILSPIFYYLWIGLGSGNSNFFYAI 354
+LGD GFF SF+PFF P+FGYLRYP+IS LLF+HAI+L+PIFY+LW+ LGSGNSNFFYAI
Sbjct: 297 SLGDAGFFFSFLPFFTPLFGYLRYPIISALLFLHAIVLAPIFYHLWVVLGSGNSNFFYAI 356
Query: 355 SLVYALAISSVIVDLTWAMLRIEYDSGKPNLSLKLTQI 392
SLVYALAI+S++VDL WAMLRIEYD+G PN LK+TQI
Sbjct: 357 SLVYALAIASILVDLNWAMLRIEYDNGIPNFKLKVTQI 394
>Hs17998700 [R] KOG2552 Major facilitator superfamily permease - Cdc91p
Length = 435
Score = 161 bits (408), Expect = 1e-39
Identities = 111/395 (28%), Positives = 187/395 (47%), Gaps = 44/395 (11%)
Query: 25 SLQQQLDRTVEFSTPVTSYRSLQEGAYLLLHNLPIYDGGVVHHVPLLVALMAF-VQQAEF 83
SL + + VE +P++S++ + EG LL + Y G V H PL++ L F + AE
Sbjct: 23 SLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHETPLIIYLFHFLIDYAEL 82
Query: 84 LMPVLFAAMDTLIAYQLMQIAKI-YQRQ---LQIPSYIPGVV------------------ 121
+ + A + + + K+ +++Q L++ Y P V
Sbjct: 83 VFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEMRYIPLKVAL 142
Query: 122 -YAVNPLVLLSCVSQSTCLFVNLSISTSLLFALSRQFSLSAICIALAGYLSPYAYLLLIP 180
Y +NP +LSCV++STC N I+ +L + LSAI +ALA Y S Y L +P
Sbjct: 143 FYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLTLFVP 202
Query: 181 -----------------LAGICGSNSFGLVVKCTLVSIVLQLISFKLNNDNWNYLTSTYW 223
A S + ++ +LV I+ +SF L + +W+++ + Y
Sbjct: 203 GLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIIC--LSFFLLS-SWDFIPAVYG 259
Query: 224 ILITFSKIRPNLGLWWYXXXXXXXXXXXXXKSVFNIFVVSFIPPFTIRFNQQSFYAFVLC 283
+++ + PN+GL+WY VF I V + P I+ + + +
Sbjct: 260 FILSVPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQINVFFYTIPLAIKLKEHPIFFMFIQ 319
Query: 284 LGWITLTKSYPTLGDGGFFLSFIPFFKPIFGYLRYPVISTLLFIHAIILSPIFYYLWIGL 343
+ I + KSYPT+GD +++F P + ++ +LR + T + I +L P+ ++LWI
Sbjct: 320 IAVIAIFKSYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYA 379
Query: 344 GSGNSNFFYAISLVYALAISSVIVDLTWAMLRIEY 378
GS NSNFFYAI+L + + +I D +A LR EY
Sbjct: 380 GSANSNFFYAITLTFNVGQILLISDYFYAFLRREY 414
>7297430 [R] KOG2552 Major facilitator superfamily permease - Cdc91p
Length = 426
Score = 138 bits (347), Expect = 2e-32
Identities = 93/384 (24%), Positives = 176/384 (45%), Gaps = 32/384 (8%)
Query: 26 LQQQLDRTVEFSTPVTSYRSLQEGAYLLLHNLPIYDGGVVHHVPLLV-ALMAFVQQAEFL 84
L + VEF+TP+ S++ +QEG +LL + Y G +VH PL++ AL Q+
Sbjct: 24 LAPMIGNRVEFATPLNSHKRMQEGIFLLQSGIDPYLGDLVHESPLILSALSGLFQKYPQF 83
Query: 85 MPVLFAAMDTLIAYQL--MQIAKIYQRQ------------------------LQIPSYIP 118
+P+ + +D A L M + + Q+Q L IP +
Sbjct: 84 LPIFYIILDICTAALLYAMSLRFVKQKQDQQDKERKEYAKDTEELQFGPLDKLDIPELVI 143
Query: 119 GVVYAVNPLVLLSCVSQSTCLFVNLSISTSLLFALSRQFSLSAICIALAGYLSPYAYLLL 178
V Y +PL ++SC+ ++ + NL ++ + + +A S Y +L+
Sbjct: 144 -VAYLFSPLTVMSCIGMTSTVISNLFLAFFFYCLVKGMLIPCLLVLAFETVRSFYPIVLI 202
Query: 179 IPLAGICGSNSFGLVVKCTLVSIVLQLISFKLNN---DNWNYLTSTYWILITFSKIRPNL 235
PL + NS V + IV LI N ++WN+L T + F ++PN+
Sbjct: 203 APLLLVFSRNSVRRGVAIAALFIVSCLIVAVANYFVLNSWNFLDGTLGFIFYFRDLQPNI 262
Query: 236 GLWWYXXXXXXXXXXXXXKSVFNI-FVVSFIPPFTIRFNQQSFYAFVLCLGWITLTKSYP 294
GL+WY F + V ++ P +I+ ++ + + + + ++YP
Sbjct: 263 GLFWYFFTEMFEHFRTMFLITFQLNATVLYLVPLSIKLRKEPLLLATVLVALMAVFRAYP 322
Query: 295 TLGDGGFFLSFIPFFKPIFGYLRYPVISTLLFIHAIILSPIFYYLWIGLGSGNSNFFYAI 354
+LGD GF+L+ +P +K + ++ + + F+ + + ++LWI GS N+NF++
Sbjct: 323 SLGDVGFYLALLPLWKRCWKFMAHGFVVFTFFLVTLSMMGALWHLWIYAGSANANFYFGA 382
Query: 355 SLVYALAISSVIVDLTWAMLRIEY 378
+L ++ +I DL +A ++ E+
Sbjct: 383 TLAFSTGQIFLITDLLFAHVKREF 406
>At1g12730 [R] KOG2552 Major facilitator superfamily permease - Cdc91p
Length = 474
Score = 114 bits (286), Expect = 2e-25
Identities = 101/424 (23%), Positives = 170/424 (39%), Gaps = 74/424 (17%)
Query: 9 VWACFASRLAVSYLFPSLQQQLDRTVEFSTPVTSYRSLQEGAYLLLHNLPIYDGGVVHHV 68
+W ++ + +F L E STP TS R L EG +L +L Y G + H
Sbjct: 21 IWTLASTIFRLFLIFSPANINLSSRPEVSTPHTSLRRLAEGYWLKQSSLSPYAGSMYHGS 80
Query: 69 PLLVALMA--FVQQAEFLMP------VLFAAMDTLIAYQLMQIAKIYQRQLQIP------ 114
PLL++++ VQ +F++ V+ A D L A L I + Q+ ++
Sbjct: 81 PLLLSILGPLTVQSDKFVVAGSKGNRVIICA-DLLSALLLRAIGQKLQKSYRMNLRPLGV 139
Query: 115 ------------SYIPGVVYAVNPLVLLSCVSQSTCLFVNLSISTSLLFALSRQFSLSAI 162
I +VY NP +LSCV ST NL++ SL A++R+ L+A
Sbjct: 140 LRSSQDRGILPCGDIAALVYLWNPFTILSCVGLSTSPIENLAVIVSLYGAVTRRVPLAAF 199
Query: 163 CIALAGYLSPYAYLLLIPLAGICGSNSFGLVVKCTLVS---------------------- 200
+ +A +LS Y+ L+ PL + G +K L +
Sbjct: 200 GLIMATHLSLYSAPLVFPLIFLLGYGLDAPPIKKFLQTRHGGVETGSTSDVSKQEKLTPT 259
Query: 201 ------------------------IVLQLISFKLNNDNWNYLTSTYWILITFSKIRPNLG 236
+VL +S K TY ++ + PN+G
Sbjct: 260 TQLPFSWRTVLHFVFWVLVWSSYVLVLCSLSLKQYGGLEEMFKRTYGFILRIEDLSPNIG 319
Query: 237 LWWYXXXXXXXXXXXXXKSVFNIFVV-SFIPPFTIRFNQQSFYAFVLCLGWITLTKSYPT 295
++WY +FN++++ + IP R + + L + ++ KSYP+
Sbjct: 320 VFWYFFAEAFEFSRNYLLIIFNLYILLTSIPSLMFRLKHRPCFLAFAYLAFTSILKSYPS 379
Query: 296 LGDGGFFLSFIPFFKPIFGYLRYPVISTLLFIHAIILSPIFYYLWIGLGSGNSNFFYAIS 355
+GD +LS F + Y +I +LSP+ + WI G+GN+NF++ +
Sbjct: 380 VGDAALYLSLWALFVNELTDMEYSFFIFCGYIGFSLLSPVMHNFWIWRGTGNANFYFGNA 439
Query: 356 LVYA 359
+ YA
Sbjct: 440 MGYA 443
>CE06491 [R] KOG2552 Major facilitator superfamily permease - Cdc91p
Length = 326
Score = 65.1 bits (157), Expect = 2e-10
Identities = 30/117 (25%), Positives = 61/117 (51%), Gaps = 1/117 (0%)
Query: 264 FIP-PFTIRFNQQSFYAFVLCLGWITLTKSYPTLGDGGFFLSFIPFFKPIFGYLRYPVIS 322
F+P P T + + F + +++ YPTL L+F+P + RY ++
Sbjct: 192 FMPIPITFLIRKDTILHFTIIGFLVSIFFPYPTLNQVSLLLAFLPVHDVYKKHFRYTILI 251
Query: 323 TLLFIHAIILSPIFYYLWIGLGSGNSNFFYAISLVYALAISSVIVDLTWAMLRIEYD 379
+ + L P+ +++WI SGN+NFF+ ++VY +A+ ++++D+ + R + D
Sbjct: 252 AGTIVSTVFLMPVMWHMWIVSSSGNANFFFGTTIVYNVALINLVMDMIFVYSRRQID 308
>SPAC1952.01 [R] KOG2552 Major facilitator superfamily permease - Cdc91p
Length = 166
Score = 52.8 bits (125), Expect = 9e-07
Identities = 36/132 (27%), Positives = 64/132 (48%), Gaps = 10/132 (7%)
Query: 30 LDRTVEFSTPVTSYRSLQEGAYLLLHNLPIYDGGVVHHVPLLV------ALMAFVQQAEF 83
L R +E STPV+ + ++EG YL + L Y GGV + PLL+ L+ + F
Sbjct: 32 LYRRIEVSTPVSGFLRVREGLYLYENGLDPYSGGVFYQSPLLLILNYCCELLGGISVTRF 91
Query: 84 LMPVLFAAMDTLIAYQLMQIAKIYQRQLQIPSYIP---GVVYAVNPLVLLSCVSQSTCLF 140
+ + + M L Y + + A++ + + P V+Y +NPL L ++ S +
Sbjct: 92 VYTSI-STMGGLFVYLIAKQARVLDPNQVLSTCSPLWISVIYLLNPLTFLPGIACSADMI 150
Query: 141 VNLSISTSLLFA 152
+N + ++ FA
Sbjct: 151 LNFTTLMTIYFA 162
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.330 0.143 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,275,037
Number of Sequences: 60738
Number of extensions: 834112
Number of successful extensions: 2356
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 2337
Number of HSP's gapped (non-prelim): 7
length of query: 392
length of database: 30,389,216
effective HSP length: 108
effective length of query: 284
effective length of database: 23,829,512
effective search space: 6767581408
effective search space used: 6767581408
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)