ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1277 good O KOG0959 Posttranslational modification, protein turnover, chaperones N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1277 447645 450656 1004
(1004 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR389c [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 1185 0.0
Hs4826770 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 674 0.0
SPACUNK4.12c [O] KOG0959 N-arginine dibasic convertase NRD1 and ... 643 0.0
7296294 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 625 e-178
CE10402 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 548 e-155
At2g41790 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 542 e-153
At3g57470 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 504 e-142
CE06756 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 486 e-137
CE06755 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 484 e-136
At1g06900 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 473 e-133
Hs4505453 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 431 e-120
7292708 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 348 2e-95
CE01818 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 310 6e-84
ECU06g0750 [O] KOG0959 N-arginine dibasic convertase NRD1 and re... 238 5e-62
7296373 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 211 5e-54
YPR122w [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 149 3e-35
CE16673 [O] KOG0959 N-arginine dibasic convertase NRD1 and relat... 110 8e-24
YLR163c [O] KOG0960 Mitochondrial processing peptidase beta subu... 64 9e-10
At3g02090 [O] KOG0960 Mitochondrial processing peptidase beta su... 57 2e-07
At3g57460 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 56 2e-07
At5g42390 [O] KOG0959 N-arginine dibasic convertase NRD1 and rel... 53 2e-06
Hs4758734 [O] KOG0960 Mitochondrial processing peptidase beta su... 51 8e-06
>YLR389c [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 988
Score = 1185 bits (3066), Expect = 0.0
Identities = 554/937 (59%), Positives = 726/937 (77%), Gaps = 4/937 (0%)
Query: 26 LTSRYRFLHYNTKMSNKYRTLGTDSEFLKPDLDDRKYRYIQLPNNLKALLISXXXXXXXX 85
L+ Y YN M++ ++T D FLKPDLD+R YR+I+LPN LKALLI
Sbjct: 42 LSRYYTTNPYN--MTSNFKTFNLD--FLKPDLDERSYRFIELPNKLKALLIQDPKADKAA 97
Query: 86 XXXXVNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNT 145
VNIG+F+DP++LPGLAHFCEHLLFMG+EK+PDEN+YSS+LSKHGGSSNAYT SQNT
Sbjct: 98 ASLDVNIGAFEDPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNT 157
Query: 146 NYYFHLNHENLYPALDRFSGFFSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKS 205
NY+F +NH++L+ ALDRFSGFFSCPLFNK STDKEINAV+SENKKNLQNDIWR+YQLDKS
Sbjct: 158 NYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKS 217
Query: 206 LTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRNELLDFHKNNYSANLMKLCVLGREDLDTL 265
LTN +HPYHKFSTGNI+TLG +PK G+++R+ELL FHKN YSANLMKLC+LGREDLDTL
Sbjct: 218 LTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTL 277
Query: 266 ADWVYELFKDVPNLNKQVPYYPARLYTESQLKKMVYCKPVKDLKKIEFTFPTPDMDPYWE 325
+DW Y+LFKDV N ++VP Y + L+K++ +PVKDLKK+E +F PDM+ +WE
Sbjct: 278 SDWTYDLFKDVANNGREVPLYAEPIMQPEHLQKIIQVRPVKDLKKLEISFTVPDMEEHWE 337
Query: 326 SKPNHYLSHLIGHEGNGSLLAFLKEKGWAVELSAGSHTISKDNAVFGIEIDLTDDGMNHV 385
SKP LSHLIGHEG+GSLLA LK+ GWA ELSAG HT+SK NA F ++IDLTD+G+ H
Sbjct: 338 SKPPRILSHLIGHEGSGSLLAHLKKLGWANELSAGGHTVSKGNAFFAVDIDLTDNGLTHY 397
Query: 386 NEIIISTFQYLEMLKVTLPEEWIHNELKSTSVSSFKFKQKDPPSSTVSNMARCLEKEYIP 445
++I+ FQY+EMLK +LP++WI NEL+ S ++FKFKQ PSSTVS++A+CLEK+YIP
Sbjct: 398 RDVIVLIFQYIEMLKNSLPQKWIFNELQDISNATFKFKQAGSPSSTVSSLAKCLEKDYIP 457
Query: 446 VVDILSTSLIREYNPSMIKKYVQSLNWENSRIMLTGQNLPVDCKEQWYGTEYKVTDYPES 505
V IL+ L+ +Y P ++ +Y +L ENSR+ L ++L D E+WYGT YKV DYP
Sbjct: 458 VSRILAMGLLTKYEPDLLTQYTDALVPENSRVTLISRSLETDSAEKWYGTAYKVVDYPAD 517
Query: 506 LLKKLPNVGLNPKFHLPRPNEFICTKFEVNKLDNVKPLDEPFLLKDDHYSKLWYKKDDRF 565
L+K + + GLNP LPRPNEF+ T F+V+K+D +KPLDEP LL D SKLWYKKDDRF
Sbjct: 518 LIKNMKSPGLNPALTLPRPNEFVSTNFKVDKIDGIKPLDEPVLLLSDDVSKLWYKKDDRF 577
Query: 566 WVPKGHIYVSMKLPHTFSSVVNSMLTSLYVDMIKDALVDLQYDASCADLRITLGKTNQGI 625
W P+G+IY+S KLPHT +S++NSML++LY + DAL D+QYDA+CADLRI+ KTNQG+
Sbjct: 578 WQPRGYIYLSFKLPHTHASIINSMLSTLYTQLANDALKDVQYDAACADLRISFNKTNQGL 637
Query: 626 DIQASGYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPYNQISNVFN 685
I ASG+NEKL ILLTRFL+G+ SF+PK+ RF ++K++ ++ L N Y+VPY+Q+SN +N
Sbjct: 638 AITASGFNEKLIILLTRFLQGVNSFEPKKDRFEILKDKTIRHLKNLLYEVPYSQMSNYYN 697
Query: 686 SLVNERSWTTKAKLDVTKDLTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAYEINQLVDI 745
+++NERSW+T KL V + LTFE L +F+PTIYE ++ E+L+ GN E A E++ L+
Sbjct: 698 AIINERSWSTAEKLQVFEKLTFEQLINFIPTIYEGVYFETLIHGNIKHEEALEVDSLIKS 757
Query: 746 LVVDRIPNLEVKNNKLRSYILPEESAFRYEYMLEDKANVNSCIQYLIQLGAYSEELAAKA 805
L+ + I NL+V NN+LRSY+LP+ FRYE L+D NVNSCIQ++ QL YSE+L+A +
Sbjct: 758 LIPNNIHNLQVSNNRLRSYLLPKGKTFRYETALKDSQNVNSCIQHVTQLDVYSEDLSALS 817
Query: 806 SLVSQLIHEPCFDTLRTKEQLGYIVFSAVANTHGTTNLRVLVQSERDSAYVESRIVKFLN 865
L +QLIHEPCFDTLRTKEQLGY+VFS+ N HGT N+R+L+QSE + Y+E RI F
Sbjct: 818 GLFAQLIHEPCFDTLRTKEQLGYVVFSSSLNNHGTANIRILIQSEHTTPYLEWRINNFYE 877
Query: 866 SFGEALKEMPEEAFEKHKSGLIKNLLQKLTNLRQEYDRFTTAIYLADYNFCSYQRRADII 925
+FG+ L++MPEE FEKHK L +LLQK N+ +E R+T AIYL DYNF Q++A ++
Sbjct: 878 TFGQVLRDMPEEDFEKHKEALCNSLLQKFKNMAEESARYTAAIYLGDYNFTHRQKKAKLV 937
Query: 926 TKLSKEDMVEFYKNFVLSPRSSRLAIHLKSQIEKKST 962
++K+ M++FY+N+++S +S+L +HLKSQ+E KS+
Sbjct: 938 ANITKQQMIDFYENYIMSENASKLILHLKSQVETKSS 974
>Hs4826770 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1019
Score = 674 bits (1739), Expect = 0.0
Identities = 367/954 (38%), Positives = 551/954 (57%), Gaps = 27/954 (2%)
Query: 58 DDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLLFMGNE 117
D R+YR ++L N +K LL+S V+IGS DP ++ GL+HFCEH+LF+G +
Sbjct: 60 DKREYRGLELANGIKVLLMSDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTK 119
Query: 118 KYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCPLFNKAST 177
KYP EN+YS FLS+H GSSNA+T ++TNYYF ++HE+L ALDRF+ FF CPLF+++
Sbjct: 120 KYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCK 179
Query: 178 DKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRN 237
D+E+NAVDSE++KN+ ND WR++QL+K+ N +HP+ KF TGN TL P +GID+R
Sbjct: 180 DREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQ 239
Query: 238 ELLDFHKNNYSANLMKLCVLGREDLDTLADWVYELFKDVPNLNKQVPYYPARLYTESQLK 297
ELL FH YS+NLM +CVLGRE LD L + V +LF +V N N +P +P + E LK
Sbjct: 240 ELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299
Query: 298 KMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLAFLKEKGWAVEL 357
++ P+KD++ + TFP PD+ Y++S P HYL HLIGHEG GSLL+ LK KGW L
Sbjct: 300 QLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTL 359
Query: 358 SAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEEWIHNELKSTSV 417
G ++ F I +DLT++G+ HV +II+ FQY++ L+ P+EW+ E K +
Sbjct: 360 VGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNA 419
Query: 418 SSFKFKQKDPPSSTVSNMARCLEKEYIPVVDILSTS-LIREYNPSMIKKYVQSLNWENSR 476
+F+FK K+ P S +A L Y P+ ++L+ L+ E+ P +I+ + L EN R
Sbjct: 420 VAFRFKDKERPRGYTSKIAGIL--HYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVR 477
Query: 477 IMLTGQNL--PVDCKEQWYGTEYKVTDYPESLLKKLPNVGLNPKFHLPRPNEFICTKFEV 534
+ + ++ D E+WYGT+YK P+ ++KK N LN KF LP NEFI T FE+
Sbjct: 478 VAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEI 537
Query: 535 NKLDNVKPLDEPFLLKDDHYSKLWYKKDDRFWVPKGHIYVSMKLPHTFSSVVNSMLTSLY 594
L+ + P L+KD SKLW+K+DD+ PK + P + ++ + LY
Sbjct: 538 LPLEK-EATPYPALIKDTVMSKLWFKQDDKKKKPKACLNFEFFSPFAYVDPLHCNMAYLY 596
Query: 595 VDMIKDALVDLQYDASCADLRITLGKTNQGIDIQASGYNEKLTILLTRFLEGIKSFQPKE 654
++++KD+L + Y A A L L T G+ + GYN+K ILL + +E + +F+ E
Sbjct: 597 LELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDE 656
Query: 655 SRFNVIKNRLLQKLSNQQYDVPYNQISNVFNSLVNERSWTTKAKLDVTKDLTFEHLKSFV 714
RF +IK ++ L+N + + P+ L+ E +WT + D+T LK+F+
Sbjct: 657 KRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFI 716
Query: 715 PTIYEQLFHESLVLGNFSVEMAYEINQLVDILVVDRI---PNLEVKNNKLRSYILPEESA 771
P + +L E+L+ GN + + A I Q+V+ +++ P L + + R LP+
Sbjct: 717 PQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGW 776
Query: 772 FRYEYMLEDKANVNSCIQYLIQLGAYSEELAAKASLVSQLIHEPCFDTLRTKEQLGYIVF 831
F Y+ E N I Y + + SE + + L Q+I EPCF+TLRTKEQLGYIVF
Sbjct: 777 FVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLE--LFCQIISEPCFNTLRTKEQLGYIVF 834
Query: 832 SAVANTHGTTNLRVLVQSERDSAYVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNLL 891
S +G +LR ++QSE+ Y+ESR+ FL + +++++M EEAF+KH L L
Sbjct: 835 SGPRRANGIQSLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRL 894
Query: 892 QKLTNLRQEYDRFTTAIYLADYNFCSYQRRADIITKLSKEDMVEFYKNF--VLSPRSSRL 949
K L E ++ I YNF + L+KED+++FYK V +PR ++
Sbjct: 895 DKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKV 954
Query: 950 AIHLKSQIEKKSTEEVVE-------------GFPTGTLISDIDEFKSNLFLAPV 990
++H+ ++ E S V E P +I ++ EFK L L P+
Sbjct: 955 SVHVLAR-EMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPL 1007
>SPACUNK4.12c [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 969
Score = 643 bits (1659), Expect = 0.0
Identities = 354/955 (37%), Positives = 557/955 (58%), Gaps = 10/955 (1%)
Query: 55 PDLDDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLLFM 114
P+LDDR+YR I+L N+L+ LL+ V+IGS +P L GLAHFCEHLLFM
Sbjct: 17 PNLDDREYRLIKLENDLEVLLVRDPETDNASAAIDVHIGSQSNPRELLGLAHFCEHLLFM 76
Query: 115 GNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCPLFNK 174
G +KYPDEN+Y +L H G SNAYT S NTNYYF ++H+ LY ALDRF+ FF PLF +
Sbjct: 77 GTKKYPDENEYRKYLESHNGISNAYTASNNTNYYFEVSHDALYGALDRFAQFFIDPLFLE 136
Query: 175 ASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGID 234
D+EI AVDSE+ KNLQ+D WR ++L L+N + + KF+TGNI+TLGD+PK G+D
Sbjct: 137 ECKDREIRAVDSEHCKNLQSDSWRFWRLYSVLSNPKSVFSKFNTGNIETLGDVPKELGLD 196
Query: 235 IRNELLDFHKNNYSANLMKLCVLGREDLDTLADWVYELFKDVPNLNKQVPYYPARLYTES 294
+R ELL F+ YSAN+MKL ++GRE LD L DW ELF + N +P +P YT++
Sbjct: 197 VRQELLKFYDKYYSANIMKLVIIGREPLDVLQDWAAELFSPIKNKAVPIPKFPDPPYTDN 256
Query: 295 QLKKMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLAFLKEKGWA 354
+++K+ Y KPVK+L++++ FP P ++ +P Y+ HL+GHEG GS LA+LK G A
Sbjct: 257 EVRKICYVKPVKNLRRLDIVFPIPGQYHKYKCRPAEYVCHLLGHEGEGSYLAYLKSLGLA 316
Query: 355 VELSAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEEWIHNELKS 414
L A + +I++D + + LT++G+ +I F+Y+ +L T +++ E +
Sbjct: 317 TSLIAFNVSITEDADIIVVSTFLTEEGLTDYQRVIKILFEYIRLLDQTNAHKFLFEETRI 376
Query: 415 TSVSSFKFKQKDPPSSTVSNMARCLEKEYIPVVDILSTSLIREYNPSMIKKYVQSLNWEN 474
S + FK +QK P +A L++EY + +S++ E++P I++ V+SL N
Sbjct: 377 MSEAQFKTRQKTPAYQYAHVVASKLQREYPRDKVLYYSSVLTEFDPKGIQEVVESLRPNN 436
Query: 475 SRIMLTGQNLP--VDCKEQWYGTEYKVTDYPESLLKKLPNVGLNPKFHLPRPNEFICTKF 532
+L ++ +D KE++YG +Y + D + L ++ + + +LP NEFI
Sbjct: 437 FFAILAAHSIEKGLDNKEKFYGIDYGLEDLDSQFIDSLLHIKTSSELYLPLANEFIPWSL 496
Query: 533 EVNKLDNVKPLDEPFLLKDDHYSKLWYKKDDRFWVPKGHIYVSMKLPHTFSSVVNSMLTS 592
EV K L P L+++D + +LW+KKDD FWVPK +++++ P S S+ T+
Sbjct: 497 EVEKQPVTTKLKVPNLVRNDKFVRLWHKKDDTFWVPKANVFINFISPIARRSPKVSVSTT 556
Query: 593 LYVDMIKDALVDLQYDASCADLRITLGKTNQGIDIQASGYNEKLTILLTRFLEGIKSFQP 652
LY +I+DAL + Y AS A L +L + +GI + SG+ +KL +LL + + ++ +
Sbjct: 557 LYTRLIEDALGEYSYPASLAGLSFSLSPSTRGIILCISGFTDKLHVLLEKVVAMMRDLKV 616
Query: 653 KESRFNVIKNRLLQKLSNQQYDVPYNQISNVFNSLVNERSWTTKAKLDVTKDLTFEHLKS 712
RF ++KNRL Q+L + Y++ ++V L SW+ + KD+ +
Sbjct: 617 HPQRFEILKNRLEQELKDYDALEAYHRSNHVLTWLSEPHSWSNAELREAIKDVQVGDMSD 676
Query: 713 FVPTIYEQLFHESLVLGNFSVEMAYEINQLVDILVVDRIPNLEVKNNKLRSYILPEESAF 772
F+ + +Q F ESLV GN++ E A + + L +D P + ++ R+ I+PE +
Sbjct: 677 FISDLLKQNFLESLVHGNYTEEDAKNLIESAQKL-IDPKPVFASQLSRKRAIIVPEGGNY 735
Query: 773 RYEYMLEDKANVNSCIQYLIQLGAYSEELA-AKASLVSQLIHEPCFDTLRTKEQLGYIVF 831
Y+ ++ +K NS I Y +Q+ +E + A L Q++ EP F LRTKEQLGYIVF
Sbjct: 736 IYKTVVPNKEEKNSAIMYNLQISQLDDERSGALTRLARQIMKEPTFSILRTKEQLGYIVF 795
Query: 832 SAVANTHGTTNLRVLVQSERDSAYVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNLL 891
+ V NL + VQSER S Y+ESRI L+ F EM +E F KHKS LI +L
Sbjct: 796 TLVRQVTPFINLNIFVQSERSSTYLESRIRALLDQFKSEFLEMSDEDFSKHKSSLINFML 855
Query: 892 QKLTNLRQEYDRFTTAIYLADYNFCSYQRRADIITKLSKEDMVEFYKNFV--LSPRSSRL 949
+K TNL++E + I Y+F +++A+I++ ++K++ F+ N + + ++
Sbjct: 856 EKHTNLKEESSMYWLRICDGFYDFTRLEKQAEIVSTITKDEFYSFFINNIHYEGENTKKI 915
Query: 950 AIHLKSQIEKKSTEEVVEGFPTGTLISDIDEFKSNLFLAPVRQAVKQYEPTNARL 1004
++H+ SQ + +EV E P T+I + + FK ++ L+ +K ++ + L
Sbjct: 916 SVHVVSQ---RCEDEVYE-IPNVTIIENGNMFKESMTLSKAAFPLKPFDEIDRSL 966
>7296294 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 990
Score = 625 bits (1612), Expect = e-178
Identities = 341/947 (36%), Positives = 540/947 (57%), Gaps = 19/947 (2%)
Query: 58 DDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLLFMGNE 117
D R YR +QL N LK LLIS V +G DP +LPGLAHFCEH+LF+G E
Sbjct: 33 DTRDYRGLQLENGLKVLLISDPNTDVSAAALSVQVGHMSDPTNLPGLAHFCEHMLFLGTE 92
Query: 118 KYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCPLFNKAST 177
KYP EN Y+++LS+ GGSSNA T T Y+FH+ + L ALDRF+ FF PLF ++T
Sbjct: 93 KYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSAT 152
Query: 178 DKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRN 237
++EINAV+SE++KNL +D+WR+ Q+++ L +H Y KF +GN TL +IPK K ID+R+
Sbjct: 153 EREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRD 212
Query: 238 ELLDFHKNNYSANLMKLCVLGREDLDTLADWVYELFKDVPNLNKQVPYYPARLYTESQLK 297
ELL FHK YSAN+M L V+G+E LD L V E F ++ N N +VP +P Y E +
Sbjct: 213 ELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEERYG 272
Query: 298 KMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLAFLKEKGWAVEL 357
+ V P+KD++ + +F T D+ +++S P++YL+HLIGHEG GS+L+ L+ GW +L
Sbjct: 273 QKVKIVPIKDIRSLTISFTTDDLTQFYKSGPDNYLTHLIGHEGKGSILSELRRLGWCNDL 332
Query: 358 SAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEEWIHNELKSTSV 417
AG F I +DLT +G+ HV++I+ FQYLEML+ P++WI +E +
Sbjct: 333 MAGHQNTQNGFGFFDIVVDLTQEGLEHVDDIVKIVFQYLEMLRKEGPKKWIFDECVKLNE 392
Query: 418 SSFKFKQKDPPSSTVSNMARCLEKEYIPVVDIL-STSLIREYNPSMIKKYVQSLNWENSR 476
F+FK+K+ P + V++ + + P+ ++L + L E+ P +IK + L SR
Sbjct: 393 MRFRFKEKEQPENLVTHAVSSM--QIFPLEEVLIAPYLSNEWRPDLIKGLLDELVPSKSR 450
Query: 477 IMLTGQNLPVDC--KEQWYGTEYKVTDYPESLLKKLPNVGLNPKFHLPRPNEFICTKFEV 534
I++ Q+ DC E +Y T+Y +T + ++ N LN L PN FI T F++
Sbjct: 451 IVIVSQSFEPDCDLAEPYYKTKYGITRVAKDTVQSWENCELNENLKLALPNSFIPTNFDI 510
Query: 535 NKLDNVKPLDEPFLLKDDHYSKLWYKKDDRFWVPKGHIYVSMKLPHTFSSVVNSMLTSLY 594
+ + P P ++ D ++W+K+D++F PK + M P + +N L +
Sbjct: 511 SDVPADAP-KHPTIILDTPILRVWHKQDNQFNKPKACMTFDMSNPIAYLDPLNCNLNHMM 569
Query: 595 VDMIKDALVDLQYDASCADLRITLGKTNQGIDIQASGYNEKLTILLTRFLEGIKSFQPKE 654
V ++KD L + YDA A L++++ + GID G+++K +LL + L+ + F E
Sbjct: 570 VMLLKDQLNEYLYDAELASLKLSVMGKSCGIDFTIRGFSDKQVVLLEKLLDHLFDFSIDE 629
Query: 655 SRFNVIKNRLLQKLSNQQYDVPYNQISNVFNSLVNERSWTTKAKLDVTKDLTFEHLKSFV 714
RF+++K ++ L N + + PY L+ E +W LD + +T++ + +F
Sbjct: 630 KRFDILKEEYVRSLKNFKAEQPYQHSIYYLALLLTENAWANMELLDAMELVTYDRVLNFA 689
Query: 715 PTIYEQLFHESLVLGNFSVEMAYEI----NQLVDILVVDRIPNLEVKNNKLRSYILPEES 770
+++L E + GN + + A +I N ++ ++P L + K R Y L
Sbjct: 690 KEFFQRLHTECFIFGNVTKQQATDIAGRVNTRLEATNASKLPILARQMLKKREYKLLAGD 749
Query: 771 AFRYEYMLEDKANVNSCIQYLIQLGAYSEELAAKASLVSQLIHEPCFDTLRTKEQLGYIV 830
++ +E E++ + +SC Q +Q GA ++ +LVSQ++ EPC+D LRTKEQLGYIV
Sbjct: 750 SYLFE--KENEFHKSSCAQLYLQCGAQTDHTNIMVNLVSQVLSEPCYDCLRTKEQLGYIV 807
Query: 831 FSAVANTHGTTNLRVLVQSERDSAYVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNL 890
FS V +G +R++VQS + +YVE RI FL ++ + +++MP + FE+HK L
Sbjct: 808 FSGVRKVNGANGIRIIVQSAKHPSYVEDRIENFLQTYLQVIEDMPLDEFERHKEALAVKK 867
Query: 891 LQKLTNLRQEYDRFTTAIYLADYNFCSYQRRADIITKLSKEDMVEFYKNFVLSPRSSR-- 948
L+K + Q++ +F I + Y+F + I+ K+SK D V+++K F+ R
Sbjct: 868 LEKPKTIFQQFSQFYGEIAMQTYHFEREEAEVAILRKISKADFVDYFKKFIAKDGEERRV 927
Query: 949 LAIHLKS-QIEKKSTEEV----VEGFPTGTLISDIDEFKSNLFLAPV 990
L++H+ S Q ++ +T E + ISDI FKS L P+
Sbjct: 928 LSVHIVSQQTDENATSEAEPVEITNMERHKPISDIVTFKSCKELYPI 974
>CE10402 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1067
Score = 548 bits (1413), Expect = e-155
Identities = 317/938 (33%), Positives = 503/938 (52%), Gaps = 34/938 (3%)
Query: 58 DDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLLFMGNE 117
D R+YR ++L N ++ LL+S V +G DP LPGLAHFCEH+LF+G
Sbjct: 81 DAREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHMLFLGTA 140
Query: 118 KYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCPLFNKAST 177
KYP EN+YS FL+ H GSSNAYT S +TNY+F + + L ALDRF FF P F +++T
Sbjct: 141 KYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQFTESAT 200
Query: 178 DKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRN 237
++E+ AVDSE+ NL ND+WR Q+D+S + H Y KF TGN +TL + + KGI+ R+
Sbjct: 201 EREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKKGIEPRD 260
Query: 238 ELLDFHKNNYSANLMKLCVLGREDLDTLADWVYEL-FKDVPNLNKQVPYYPARLYTESQL 296
LL FHK YS+++M C++G+E L+ L ++ L F + N + + Y QL
Sbjct: 261 ALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFPYGPDQL 320
Query: 297 KKMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLAFLKEKGWAVE 356
K + P+KD + + +FP PD++ + S+P HY+SHLIGHEG GSLL+ LK GW
Sbjct: 321 AKRIDVVPIKDTRLVSISFPFPDLNGEFLSQPGHYISHLIGHEGPGSLLSELKRLGWVSS 380
Query: 357 LSAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEEWIHNELKSTS 416
L + SHT + V+ + +DL+ +G+ HV+EII F Y+ ML+ P++W+H+EL S
Sbjct: 381 LQSDSHTQAAGFGVYNVTMDLSTEGLEHVDEIIQLMFNYIGMLQSAGPKQWVHDELAELS 440
Query: 417 VSSFKFKQKDPPSSTVSNMARCLEKEYIPVVDILSTS-LIREYNPSMIKKYVQSLNWENS 475
F+FK K+ P + N+A L +YIP ILS+ L+ +Y P IK+ + L+ N
Sbjct: 441 AVKFRFKDKEQPMTMAINVAASL--QYIPFEHILSSRYLLTKYEPERIKELLSMLSPANM 498
Query: 476 RIMLTGQNL---PVDCKEQWYGTEYKVTDYPESLLKKLPNV--GLNPKFHLPRPNEFICT 530
++ + Q + E YGTE KVTD +KK N + HLP NE+I T
Sbjct: 499 QVRVVSQKFKGQEGNTNEPVYGTEMKVTDISPETMKKYENALKTSHHALHLPEKNEYIAT 558
Query: 531 KFEVNKLDNVKPLDEPFLLKDDHYSKLWYKKDDRFWVPKGHIYVSMKLPHTFSSVVNSML 590
F+ ++VK + P L+ DD +S++W+K+DD + +PK +++ P + S+L
Sbjct: 559 NFDQKPRESVKN-EHPRLISDDGWSRVWFKQDDEYNMPKQETKLALTTPMVAQNPRMSLL 617
Query: 591 TSLYVDMIKDALVDLQYDASCADLRITLGKTNQGIDIQAS----------------GYNE 634
+SL++ + D L + Y+A A L+ L + G+ ++ S GY+E
Sbjct: 618 SSLWLWCLSDTLAEETYNADLAGLKCQLESSPFGVQMRVSNRREAERHASLTLHVYGYDE 677
Query: 635 KLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPYNQISNVFNSLVNERSWT 694
K + + +F+ ++RF+V+ L + L+N + PY + L+ ++ W+
Sbjct: 678 KQALFAKHLANRMTNFKIDKTRFDVLFESLKRALTNHAFSQPYLLTQHYNQLLIVDKVWS 737
Query: 695 TKAKLDVTKDLTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAYEIN-QLVDIL---VVDR 750
+ L V +T E ++ F + + E V GN + + A +++ +L+D+L +
Sbjct: 738 KEQLLAVCDSVTLEDVQGFAKEMLQAFHMELFVHGNSTEKEAIQLSKELMDVLKSAAPNS 797
Query: 751 IPNLEVKNNKLRSYILPEESAFRYEYMLEDKANVNSCIQYLIQLGAYSEELAAKASLVSQ 810
P ++N R L + Y ++ K + C++ Q+G + A L+ Q
Sbjct: 798 RPLYRNEHNPRRELQLNNGDEYVYRHL--QKTHDVGCVEVTYQIGVQNTYDNAVVGLIDQ 855
Query: 811 LIHEPCFDTLRTKEQLGYIVFSAVANTHGTTNLRVLVQSERDSAYVESRIVKFLNSFGEA 870
LI EP F+TLRT E LGYIV++ GT L V+VQ + +V RI FL S +
Sbjct: 856 LIREPAFNTLRTNEALGYIVWTGSRLNCGTVALNVIVQGPKSVDHVLERIEVFLESVRKE 915
Query: 871 LKEMPEEAFEKHKSGLIKNLLQKLTNLRQEYDRFTTAIYLADYNFCSYQRRADIITKLSK 930
+ EMP+E F+ SG+I L +K L + RF I YNF + ++ + K
Sbjct: 916 IAEMPQEEFDNQVSGMIARLEEKPKTLSSRFRRFWNEIECRQYNFARREEEVALLKTIKK 975
Query: 931 EDMVEFYKNFVLSPRSSR--LAIHLKSQIEKKSTEEVV 966
+D++E + + + R LA+ + + E + +
Sbjct: 976 DDVLELFDKKIRKDAAERRKLAVFVHGKNEDQEAVNTI 1013
>At2g41790 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 970
Score = 542 bits (1396), Expect = e-153
Identities = 321/949 (33%), Positives = 507/949 (52%), Gaps = 22/949 (2%)
Query: 51 EFLKPDLDDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEH 110
E LKP D+R+YR I L N L+ LLIS V++GSF DP+ L GLAHF EH
Sbjct: 14 EILKPRTDNREYRMIVLKNLLQVLLISDPDTDKCAASMSVSVGSFSDPQGLEGLAHFLEH 73
Query: 111 LLFMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCP 170
+LF +EKYP+E+ YS ++++HGGS+NAYT S+ TNY+F +N + ALDRF+ FF P
Sbjct: 74 MLFYASEKYPEEDSYSKYITEHGGSTNAYTASEETNYHFDVNADCFDEALDRFAQFFIKP 133
Query: 171 LFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKL 230
L + +T +EI AVDSEN+KNL +D WR+ QL K L+ +HPYHKFSTGN+ TL P+
Sbjct: 134 LMSADATMREIKAVDSENQKNLLSDGWRIRQLQKHLSKEDHPYHKFSTGNMDTLHVRPQA 193
Query: 231 KGIDIRNELLDFHKNNYSANLMKLCVLGREDLDTLADWVYELFKDVPNLNKQVPYYPARL 290
KG+D R+EL+ F++ +YSAN+M L V G+E LD + D V +F+++ N NK VP +P +
Sbjct: 194 KGVDTRSELIKFYEEHYSANIMHLVVYGKESLDKIQDLVERMFQEIQNTNKVVPRFPGQP 253
Query: 291 YTESQLKKMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLAFLKE 350
T L+ +V P+K K+ ++P +++ P+ YL HLIGHEG GSL LK
Sbjct: 254 CTADHLQILVKAIPIKQGHKLGVSWPVTPSIHHYDEAPSQYLGHLIGHEGEGSLFHALKT 313
Query: 351 KGWAVELSAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEEWIHN 410
GWA LSAG + D + F + IDLTD G H+ EI+ F Y+++L+ T +WI +
Sbjct: 314 LGWATGLSAGEGEWTLDYSFFKVSIDLTDAGHEHMQEILGLLFNYIQLLQQTGVCQWIFD 373
Query: 411 ELKSTSVSSFKFKQKDPPSSTVSNMARCLEKEYIPVVD-ILSTSLIREYNPSMIKKYVQS 469
EL + + F ++ K PP S + ++A + P D ++ +SL ++NP++++K V
Sbjct: 374 ELSAICETKFHYQDKIPPMSYIVDIAS--NMQIYPTKDWLVGSSLPTKFNPAIVQKVVDE 431
Query: 470 LNWENSRIMLTGQNL--PVDCKEQWYGTEYKVTDYPESLLKKLPNVGLNPKFHLPRPNEF 527
L+ N RI Q D E WY T Y + S +++ + HLP PN F
Sbjct: 432 LSPSNFRIFWESQKFEGQTDKAEPWYNTAYSLEKITSSTIQEWVQSAPDVHLHLPAPNVF 491
Query: 528 ICTKFEVNKLDNVKPLDEPFLLKDDHYSKLWYKKDDRFWVPKGHIYVSMKLPHTFSSVVN 587
I T + D+ + + P LL+ +S+LWYK D F PK ++ + P SS
Sbjct: 492 IPTDLSLKDADDKETV--PVLLRKTPFSRLWYKPDTMFSKPKAYVKMDFNCPLAVSSPDA 549
Query: 588 SMLTSLYVDMIKDALVDLQYDASCADLRITLGKTNQGIDIQASGYNEKLTILLTRFLEGI 647
++LT ++ ++ D L + Y A A L + ++ G ++ GYN KL ILL + I
Sbjct: 550 AVLTDIFTRLLMDYLNEYAYYAQVAGLYYGVSLSDNGFELTLLGYNHKLRILLETVVGKI 609
Query: 648 KSFQPKESRFNVIKNRLLQKLSNQQYDVPYNQISNVFNSLVNERSWTTKAKLDVTKDLTF 707
+F+ K RF VIK + ++ N ++ PY+Q + ++ +++W +LDV L
Sbjct: 610 ANFEVKPDRFAVIKETVTKEYQNYKFRQPYHQAMYYCSLILQDQTWPWTEELDVLSHLEA 669
Query: 708 EHLKSFVPTIYEQLFHESLVLGNF-SVEMAYEINQLVDILVVD-------RIPNLEVKNN 759
E + FVP + + F E + GN + E + + D+L D P+ + N
Sbjct: 670 EDVAKFVPMLLSRTFIECYIAGNVENNEAESMVKHIEDVLFNDPKPICRPLFPSQHLTNR 729
Query: 760 KLRSYILPEESAFRYEYMLEDKANVNSCIQYLIQLGAYSEELAAKASLVSQLIHEPCFDT 819
++ L E + Y + ++ NS + + IQ+ + K L + + F
Sbjct: 730 VVK---LGEGMKYFYHQDGSNPSDENSALVHYIQVHRDDFSMNIKLQLFGLVAKQATFHQ 786
Query: 820 LRTKEQLGYIVFSAVANTHGTTNLRVLVQSE-RDSAYVESRIVKFLNSFGEALKEMPEEA 878
LRT EQLGYI A N G ++ ++QS + +++SR+ L +F L EM E
Sbjct: 787 LRTVEQLGYITALAQRNDSGIYGVQFIIQSSVKGPGHIDSRVESLLKNFESKLYEMSNED 846
Query: 879 FEKHKSGLIKNLLQKLTNLRQEYDRFTTAIYLADYNFCSYQRRADIITKLSKEDMVEFYK 938
F+ + + LI L+K NL++E + I F + + +L K+++++F+
Sbjct: 847 FKSNVTALIDMKLEKHKNLKEESRFYWREIQSGTLKFNRKEAEVSALKQLQKQELIDFFD 906
Query: 939 NFVL--SPRSSRLAIHLKSQIEKKSTEEVVEGFPTGTL-ISDIDEFKSN 984
++ + R L+I + K + P+ ++ I DI F+ +
Sbjct: 907 EYIKVGAARKKSLSIRVYGSQHLKEMASDKDEVPSPSVEIEDIVGFRKS 955
>At3g57470 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 989
Score = 504 bits (1298), Expect = e-142
Identities = 316/976 (32%), Positives = 511/976 (51%), Gaps = 45/976 (4%)
Query: 47 GTDSEFLKPDLDDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAH 106
G E LKP D R+YR I L N+L+ LLIS V++GSF DPE L GLAH
Sbjct: 12 GECGEILKPRTDKREYRRIVLKNSLEVLLISDPETDKCAASMNVSVGSFTDPEGLEGLAH 71
Query: 107 FCEHLLFMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGF 166
F EH+LF +EKYP+E+ YS ++++HGGS+NAYT S++TNY+F +N ++ Y ALDRF+ F
Sbjct: 72 FLEHMLFYASEKYPEEDSYSKYITEHGGSTNAYTSSEDTNYHFDINTDSFYEALDRFAQF 131
Query: 167 FSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGD 226
F PL + +T +EI AVDSE++ NL +D WRM QL K L+ +HPYHKFSTGN+ TL
Sbjct: 132 FIQPLMSTDATMREIKAVDSEHQNNLLSDSWRMAQLQKHLSREDHPYHKFSTGNMDTLHV 191
Query: 227 IPKLKGIDIRNELLDFHKNNYSANLMKLCVLGREDLDTLADWVYELFKDVPNLNKQVPYY 286
P+ G+D R+EL+ F+ +YSAN+M L V G+E+LD V LF+ + N N+ +P +
Sbjct: 192 RPEENGVDTRSELIKFYDEHYSANIMHLVVYGKENLDKTQGLVEALFQGIRNTNQGIPRF 251
Query: 287 PARLYTESQLKKMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLA 346
P + T L+ +V P+ ++ ++P ++E P YL LIGHEG GSL
Sbjct: 252 PGQPCTLDHLQVLVKAVPIMQGHELSVSWPVTPSISHYEEAPCRYLGDLIGHEGEGSLFH 311
Query: 347 FLKEKGWAVELSAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEE 406
LK GWA L AG S + + F + IDLTD G H+ +I+ F+Y+++L+ + +
Sbjct: 312 ALKILGWATGLYAGEADWSMEYSFFNVSIDLTDAGHEHMQDILGLLFEYIKVLQQSGVSQ 371
Query: 407 WIHNELKSTSVSSFKFKQKDPPSSTVSNMARCLEKEYIPVVDILSTSLIREYNPSMIKKY 466
WI +EL + + F ++ K P S +++ + K Y ++ +SL ++NP++++K
Sbjct: 372 WIFDELSAICEAEFHYQAKIDPISYAVDISSNM-KIYPTKHWLVGSSLPSKFNPAIVQKV 430
Query: 467 VQSLNWENSRI--MLTGQNLPV------DC--------KEQWYGTEY---KVTDYP-ESL 506
+ L+ N + +L NL V DC E WY T Y K+T + +
Sbjct: 431 LDELSPNNPSVPNVLCSYNLHVVQALNPDCLRPRQTDKVEPWYNTAYSLEKITKFTIQEW 490
Query: 507 LKKLPNVGLNPKFHLPRPNEFICTKFEVNKLDNVKPLDEPFLLKDDHYSKLWYKKDDRFW 566
++ P+V L LP PN FI T F + L + P LL+ YS+LWYK D +F+
Sbjct: 491 MQSAPDVNL----LLPTPNVFIPTDFSLKDLKDKDIF--PVLLRKTSYSRLWYKPDTKFF 544
Query: 567 VPKGHIYVSMKLPHTFSSVVNSMLTSLYVDMIKD-----ALVDLQ----YDASCADLRIT 617
PK ++ + P SS ++L+ ++V ++ D AL++L Y A A L
Sbjct: 545 KPKAYVKMDFNCPLAVSSPDAAVLSDIFVWLLVDYLNEYALINLDYVSAYYAQAAGLDYG 604
Query: 618 LGKTNQGIDIQASGYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPY 677
L ++ G ++ +G+N KL ILL ++ I F+ K RF+VIK + + N ++ P+
Sbjct: 605 LSLSDNGFELSLAGFNHKLRILLEAVIQKIAKFEVKPDRFSVIKETVTKAYQNNKFQQPH 664
Query: 678 NQISNVFNSLVNERSWTTKAKLDVTKDLTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAY 737
Q +N + ++ ++ W +LD L E L +FVP + + F E + GN + A
Sbjct: 665 EQATNYCSLVLQDQIWPWTEELDALSHLEAEDLANFVPMLLSRTFVECYIAGNVEKDEAE 724
Query: 738 E-INQLVDILVVDRIPNLE--VKNNKLRSYILPEESAFRYEYMLE--DKANVNSCIQYLI 792
+ + D+L D P + L + + + ++ Y E + ++ NS + + I
Sbjct: 725 SMVKHIEDVLFTDSKPICRPLFPSQFLTNRVTELGTGMKHFYYQEGSNSSDENSALVHYI 784
Query: 793 QLGAYSEELAAKASLVSQLIHEPCFDTLRTKEQLGYIVFSAVANTHGTTNLRVLVQSE-R 851
Q+ + +K L + + F LRT EQLGYI +++N G ++ ++QS +
Sbjct: 785 QVHKDEFSMNSKLQLFELIAKQDTFHQLRTIEQLGYITSLSLSNDSGVYGVQFIIQSSVK 844
Query: 852 DSAYVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNLLQKLTNLRQEYDRFTTAIYLA 911
+++SR+ L M +E F+ + + LI L+K NL +E + I
Sbjct: 845 GPGHIDSRVESLLKDLESKFYNMSDEEFKSNVTNLIDMKLEKDKNLDEESWFYWAEIQTG 904
Query: 912 DYNFCSYQRRADIITKLSKEDMVEFYKNFVL--SPRSSRLAIHLKSQIEKKSTEEVVEGF 969
F + L K++ ++F+ ++ +P L+I + K +
Sbjct: 905 TLKFNRIDAEVAALRLLKKDEWIDFFDEYIKVDAPNKKSLSICVYGNQHLKEMRNDKDKI 964
Query: 970 PTGTL-ISDIDEFKSN 984
P+ ++ I DI F+ +
Sbjct: 965 PSTSIEIEDIVCFRKS 980
>CE06756 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 845
Score = 486 bits (1251), Expect = e-137
Identities = 285/807 (35%), Positives = 442/807 (54%), Gaps = 36/807 (4%)
Query: 50 SEFLKPDLDDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCE 109
+ +K D+R+ R ++L N L+ LL+S V G DP LPGLAHFCE
Sbjct: 14 NSIVKGPQDERECRGLELTNGLRVLLVSDPTTDKSAVSLAVKAGHLMDPWELPGLAHFCE 73
Query: 110 HLLFMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSC 169
H+LF+G KYP EN+++ FLS + GS NA T +T Y+F + + LY ALDRF FF C
Sbjct: 74 HMLFLGTSKYPLENEFTKFLSDNAGSYNACTEPDHTYYHFDVKPDQLYGALDRFVQFFLC 133
Query: 170 PLFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPK 229
P F K++T++E+ AVDSE+ NL +D WR+ Q+D+SL+ H KF TGN KTL + +
Sbjct: 134 PQFTKSATEREVCAVDSEHLSNLNSDYWRILQVDRSLSRPGHDNRKFCTGNKKTLLEDAR 193
Query: 230 LKGIDIRNELLDFHKNNYSANLMKLCVLGREDLDTLADWVYEL-FKDVPNLNKQVPYYPA 288
KGI+ R+ LL+F+K YS+N+M C++G+E LD L ++ L F + N + +
Sbjct: 194 KKGIEPRDALLEFYKKWYSSNIMTCCIIGKESLDVLESYLRTLEFDAIQNKKAESKVWAE 253
Query: 289 RLYTESQLKKMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLAFL 348
Y QL K + P+KD K + FP PD++ + S+P HY++HLIGH+G GS+ + L
Sbjct: 254 FQYGPDQLAKKIDVVPIKDKKLVSIIFPFPDLNNEYLSQPGHYIAHLIGHKGPGSISSEL 313
Query: 349 KEKGWAVELSAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEEWI 408
K GWA L S TI+ F + +DL+ +G+ HV+EII F Y+ ML+ P++WI
Sbjct: 314 KRLGWASSLKPESKTIAAGFGYFNVTMDLSTEGLEHVDEIIQLMFNYIGMLQSAGPQQWI 373
Query: 409 HNELKSTSVSSFKFKQKDPPSSTVSNMARCLEKEYIPVVDILSTS-LIREYNPSMIKKYV 467
H EL S F+FK ++P + +AR L +YIP ILS+ L+ +YNP IK+ +
Sbjct: 374 HEELAELSAIEFRFKDREPLTKNAIKVARNL--QYIPFEHILSSRYLLTKYNPERIKELL 431
Query: 468 QSLNWENSRIMLTGQNLPV---DCKEQWYGTEYKVTDYPESLLKKLPNV--GLNPKFHLP 522
+L N + + + + E YGTE KVTD +KK N + HLP
Sbjct: 432 STLTPSNMLVRVVSKKFKEQEGNTNEPVYGTEMKVTDISPEKMKKYENALKTSHHALHLP 491
Query: 523 RPNEFICTKFEVNKLDNVKPLDEPFLLKDDHYSKLWYKKDDRFWVPKGHIYVSMKLPHTF 582
NE+I TKF+ ++VK + P L+ DD +S++W+K+DD + +PK ++ P
Sbjct: 492 EKNEYIVTKFDQKPRESVKN-EHPRLISDDGWSRVWFKQDDEYNMPKQETKLAFTTPIVA 550
Query: 583 SSVVNSMLTSLYVDMIKDALVDLQYDASCADLRITLGKTNQGIDIQAS------------ 630
+ + S+++SL++ + D L + Y+A+ A L+ L + G+ QA
Sbjct: 551 QNPIMSLISSLWLWCLNDTLTEETYNAAIAGLKFQLESGHNGVHEQAGNWLDPERHASIT 610
Query: 631 ----GYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPYNQISNVFNS 686
GY+EK + + + + +F+ +RF+V+ L + L+N + PY +S FN
Sbjct: 611 LHVYGYDEKQPLFVKHLTKCMTNFKIDRTRFDVVFESLKRSLTNHAFSQPY-MLSKYFNE 669
Query: 687 -LVNERSWTTKAKLDVTKDLTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAYEI-NQLVD 744
LV E+ W+ + L V T E ++ F +++ E V GN + + A ++ N+L+D
Sbjct: 670 LLVVEKVWSKEQLLAVCDSATLEDVQGFSKELFQAFHLELFVHGNSTEKKAIQLSNELMD 729
Query: 745 ILVVDRIPNLEV----KNNKLRSYILPEESAFRYEYMLEDKANVNSCIQYLIQLGAYSEE 800
IL PN + ++N R + L + Y ++ K + C++ + G +
Sbjct: 730 IL-KSAAPNSRLLYRNEHNPRREFQLNNGDEYIYRHL--QKTHDAGCVEVTFKFGVQNTY 786
Query: 801 LAAKASLVSQLIHEPCFDTLRTKEQLG 827
A A L+SQLI +P F TLRTKE LG
Sbjct: 787 DNALAGLISQLIRQPAFSTLRTKESLG 813
>CE06755 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 980
Score = 484 bits (1247), Expect = e-136
Identities = 307/978 (31%), Positives = 492/978 (49%), Gaps = 69/978 (7%)
Query: 58 DDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLLFMGNE 117
DDR+YR ++L N ++ LL+S V +G DP LPGLAHFCEH+LF+G
Sbjct: 22 DDREYRGLELTNGIRVLLVSDPTTDKSAAALDVKVGHLMDPWELPGLAHFCEHMLFLGTA 81
Query: 118 KYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCPLFNKAST 177
KYP EN+YS FL+ + G NA T S +TNY+F + + L ALDRF FF P F +++T
Sbjct: 82 KYPTENEYSKFLTDNAGHRNAVTASDHTNYHFDVKPDQLRGALDRFVQFFLSPQFTESAT 141
Query: 178 DKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRN 237
++E+ AVDSE+ NL ND+WR+ Q+D+SL+ H Y KF TGN KTL + + KG++ R+
Sbjct: 142 EREVCAVDSEHSNNLNNDLWRLSQVDRSLSKPGHDYAKFGTGNKKTLLEEARKKGVEPRD 201
Query: 238 ELLDFHKNNYSANLMKLCVLGREDLDTLADWVYEL-FKDVPNLNKQVPYYPARLYTESQL 296
LL F+K YS+N+M C++G+E LD L + L F + N + + Y QL
Sbjct: 202 ALLQFYKKWYSSNIMTCCIIGKESLDVLQSHLKTLEFDTIENKKVERKVWNENPYGPEQL 261
Query: 297 KKMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLAFLKEKGWAVE 356
K + K + +HLI H+G GSLL LK GW
Sbjct: 262 GKRIDRK---------------------------FFAHLIRHKGPGSLLVELKRLGWVNS 294
Query: 357 LSAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEEWIHNELKSTS 416
L + S+TI+ + + +DL+ G+ +V+EII Y+ MLK P++WIH+EL S
Sbjct: 295 LKSDSNTIAAGFGILNVTMDLSTGGLENVDEIIQLMLNYIGMLKSFGPQQWIHDELADLS 354
Query: 417 VSSFKFKQKDPPSSTVSNMARCLEKEYIPVVDILSTS-LIREYNPSMIKKYVQSLNWENS 475
F+FK K+ P N+A L+ YIP+ ILS+ L+ +Y P IK+ + +L N
Sbjct: 355 DVKFRFKDKEQPMKMAINIAASLQ--YIPIEHILSSRYLLTKYEPERIKELLSTLTPSNM 412
Query: 476 RIMLTGQNLPV---DCKEQWYGTEYKVTDYPESLLKKLPNV--GLNPKFHLPRPNEFICT 530
+ + Q + E YGTE KVTD +KK N + HLP NE+I T
Sbjct: 413 LVRVVSQKFKEQEGNTNEPVYGTEMKVTDISPEKMKKYENALKTSHHALHLPEKNEYIAT 472
Query: 531 KFEVNKLDNVKPLDEPFLLKDDHYSKLWYKKDDRFWVPKGHIYVSMKLPHTFSSVVNSML 590
F ++VK + P L+ DD +S++W+K+DD + +PK ++ P + S++
Sbjct: 473 NFGQKPRESVKN-EHPKLISDDGWSRVWFKQDDEYNMPKQETKFALTTPIVSQNPRISLI 531
Query: 591 TSLYVDMIKDALVDLQYDASCADLRITLGKTNQGIDIQAS----------------GYNE 634
+SL++ D L + Y+A+ A L + G+ Q++ GY+E
Sbjct: 532 SSLWLWCFCDILSEETYNAALAGLGCQFELSPFGVQKQSTDGREAERHASLTLHVYGYDE 591
Query: 635 KLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPYNQISNVFNSLVNERSWT 694
K + + + +F+ +RF V+ L + L+N + PY + L+ ++ W+
Sbjct: 592 KQPLFVKHLTSCMINFKIDRTRFEVLFESLKRTLTNHAFSQPYLLTQHYNQLLIVDKVWS 651
Query: 695 TKAKLDVTKDLTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAYEIN-QLVDIL---VVDR 750
+ L V +T E+++ F + + E V GN + + A +++ +L+DIL +
Sbjct: 652 KEQLLAVCDSVTLENVQGFAREMLQAFHMELFVHGNSTEKEAIQLSKELMDILKSAAPNS 711
Query: 751 IPNLEVKNNKLRSYILPEESAFRYEYMLEDKANVNSCIQYLIQLGAYSEELAAKASLVSQ 810
P ++N R + L + Y ++ K + C++ Q+G ++ A L+ Q
Sbjct: 712 RPLYRNEHNPRREFQLNNGDEYIYRHL--QKTHDAGCVEVTYQIGVQNKYDNAVVGLIDQ 769
Query: 811 LIHEPCFDTLRTKEQLGYIVFSAVANTHGTTNLRVLVQSERDSAYVESRIVKFLNSFGEA 870
LI EP FDTLRT E LGYIV++ G L + VQ + YV RI FL S +
Sbjct: 770 LIKEPVFDTLRTNEALGYIVWTGCRFNCGAVALNIFVQGPKSVDYVLERIEVFLESVRKE 829
Query: 871 LKEMPEEAFEKHKSGLIKNLLQKLTNLRQEYDRFTTAIYLADYNFCSYQRRADIITKLSK 930
+ EMP++ FEK +G+I L +K L + RF I Y+F ++ ++ + K
Sbjct: 830 IIEMPQDEFEKKVAGMIARLEEKPKTLSNRFKRFWYQIECRQYDFARREKEVKVLKSIGK 889
Query: 931 EDMVEFY----KNFVLSPRSSRLAIHLKSQIEKKSTEEVVEGFPTGTLISDIDEFKSNLF 986
+D++ + + + R + +H K ++ + + +G +I L
Sbjct: 890 DDVIALFDKKIRKNAVERRKLVVLVHGKIDDQETLNRIIKKNVESGKKEKEI------LN 943
Query: 987 LAPVRQAVKQYEPTNARL 1004
L +RQ++ Y+ NA +
Sbjct: 944 LDQLRQSLPVYDLPNAAI 961
>At1g06900 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1023
Score = 473 bits (1217), Expect = e-133
Identities = 294/905 (32%), Positives = 487/905 (53%), Gaps = 36/905 (3%)
Query: 90 VNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYF 149
V++GSF DP GLAHF EH+LFMG+ ++PDEN+Y S+LSKHGGSSNAYT ++T Y+F
Sbjct: 113 VSMGSFLDPPEAQGLAHFLEHMLFMGSTEFPDENEYDSYLSKHGGSSNAYTEMEHTCYHF 172
Query: 150 HLNHENLYPALDRFSGFFSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNW 209
+ E L AL RFS FF PL + ++E+ AVDSE + LQND R+ QL +
Sbjct: 173 EVKREFLQGALKRFSQFFVAPLMKTEAMEREVLAVDSEFNQALQNDACRLQQLQCYTSAK 232
Query: 210 EHPYHKFSTGNIKTLGDIPKLKGIDIRNELLDFHKNNYSANLMKLCVLGREDLDTLADWV 269
HP+++F+ G + G+D+R ++ +K Y LMKL V+G E LD L WV
Sbjct: 233 GHPFNRFAWGKDTAVLSGAMENGVDLRECIVKLYKEYYHGGLMKLVVIGGESLDMLESWV 292
Query: 270 YELFKDVPNLNKQVPYYPAR--LYTESQLKKMVYCKPVKDLKKIEFTFPTPDMDPYWESK 327
ELF DV N +K P A ++ +L ++ + VKD+ ++ T+ P + + K
Sbjct: 293 VELFGDVKNGSKIRPTLEAEGPIWKGGKLYRL---EAVKDVHILDLTWTLPPLRSAYVKK 349
Query: 328 PNHYLSHLIGHEGNGSLLAFLKEKGWAVELSA--GSHTISKDNA--VFGIEIDLTDDGMN 383
P YL+HL+GHEG GSL +FLK KGWA LSA G I++ + VFG+ I LTD G+
Sbjct: 350 PEDYLAHLLGHEGRGSLHSFLKAKGWATSLSAGVGDDGINRSSLAYVFGMSIHLTDSGLE 409
Query: 384 HVNEIIISTFQYLEMLKVTLPEEWIHNELKSTSVSSFKFKQKDPPSSTVSNMARCLEKEY 443
+ +II +QYL++L+ P+EWI EL+ F+F ++ P + ++ +
Sbjct: 410 KIYDIIGYIYQYLKLLRDVSPQEWIFKELQDIGNMDFRFAEEQPADDYAAELSENMLAYP 469
Query: 444 IPVVDILSTSLIREYNPSMIKKYVQSLNWENSRIMLTGQNLPVD--CKEQWYGTEYKVTD 501
+ V I + + ++P +I+ + +N RI + +++ + +E W+G+ Y D
Sbjct: 470 VEHV-IYGDYVYQTWDPKLIEDLMGFFTPQNMRIDVVSKSIKSEEFQQEPWFGSSYIEED 528
Query: 502 YPESLLKKLPNVG-LNPKFHLPRPNEFICTKFEVNKLD---NVKPLDEPFLLKDDHYSKL 557
P SL++ N ++ HLP N+FI F + ++ + K P + D+ + K
Sbjct: 529 VPLSLMESWSNPSEVDNSLHLPSKNQFIPCDFSIRAINSDVDPKSQSPPRCIIDEPFMKF 588
Query: 558 WYKKDDRFWVPKGHIYVSMKLPHTFSSVVNSMLTSLYVDMIKDALVDLQYDASCADLRIT 617
WYK D+ F VP+ + Y + L ++SV N +LT LY++++KD L ++ Y A+ L +
Sbjct: 589 WYKLDETFKVPRANTYFRINLKGAYASVKNCLLTELYINLLKDELNEIIYQAT--KLETS 646
Query: 618 LGKTNQGIDIQASGYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPY 677
L ++++ G+NEK+ LL++ L KSF P RF VIK + + N P
Sbjct: 647 LSMYGDKLELKVYGFNEKIPALLSKILAIAKSFMPNLERFKVIKENMERGFRNTNMK-PL 705
Query: 678 NQISNVFNSLVNERSWTTKAKLDVTKDLTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAY 737
N + + L+ +R + + KL V DL+ + L SF+P + Q+F E+L GN S + A
Sbjct: 706 NHSTYLRLQLLCKRIYDSDEKLSVLNDLSLDDLNSFIPELRSQIFIEALCHGNLSEDEAV 765
Query: 738 EINQLV-DILVVDRIPNLEVKNNKLRSYILPEESAFRYEYMLEDKANVNSCIQYLIQL-- 794
I+ + D L V+ +P+ ++ + P + + +++K+ NS ++ Q+
Sbjct: 766 NISNIFKDSLTVEPLPSKCRHGEQITCF--PMGAKLVRDVNVKNKSETNSVVELYYQIEP 823
Query: 795 -GAYSEELAAKASLVSQLIHEPCFDTLRTKEQLGYIVFSAVANTHGTTNLRVLVQSER-D 852
A S A L ++I EP F+ LRTKEQLGY+V T+ VQS +
Sbjct: 824 EEAQSTRTKAVLDLFHEIIEEPLFNQLRTKEQLGYVVECGPRLTYRVHGFCFCVQSSKYG 883
Query: 853 SAYVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNLLQKLTNLRQEYDRFTTAIYLAD 912
++ R+ F+ L+++ +E++E ++SG+I LL+K +L E + + I
Sbjct: 884 PVHLLGRVDNFIKDIEGLLEQLDDESYEDYRSGMIARLLEKDPSLLSETNDLWSQIVDKR 943
Query: 913 YNFCSYQRRADIITKLSKEDMVEFYKNFV--LSPRSSRLAIHL--------KSQIEKKST 962
Y F + A+ + + K+D++ +YK + SP+ RLA+ + ++Q ++K+
Sbjct: 944 YMFDFSHKEAEELRSIQKKDVISWYKTYFRESSPKCRRLAVRVWGCDTNMKETQTDQKAV 1003
Query: 963 EEVVE 967
+ + +
Sbjct: 1004 QVIAD 1008
>Hs4505453 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1219
Score = 431 bits (1107), Expect = e-120
Identities = 298/944 (31%), Positives = 461/944 (48%), Gaps = 47/944 (4%)
Query: 90 VNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYF 149
V +GSF DP+ LPGLAHF EH++FMG+ KYPDEN + +FL KHGGS NA T + T + F
Sbjct: 285 VGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQF 344
Query: 150 HLNHENLYPALDRFSGFFSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNW 209
+ + ALDR++ FF PL + + D+E+ AVDSE + +D R L SL
Sbjct: 345 DVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARP 404
Query: 210 EHPYHKFSTGNIKTLGDIPKLKGIDIRNELLDFHKNNYSANLMKLCVLGREDLDTLADWV 269
HP KF GN +TL P+ ID L +F YS++ M L V +E LDTL WV
Sbjct: 405 GHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWV 464
Query: 270 YELFKDVPNLNKQVPYYP--ARLYTESQLKKMVYCKPVKDLKKIEFTFPTPDMDPYWESK 327
E+F +PN P + + K+ P++ + + T+ P ++ K
Sbjct: 465 TEIFSQIPNNGLPRPNFGHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVK 524
Query: 328 PNHYLSHLIGHEGNGSLLAFLKEKGWAVELSAGSHTISKDN----AVFGIEIDLTDDGMN 383
P HY+S L+GHEG GS+L+FL++K WA+ L G+ + +VF I I LTD+G
Sbjct: 525 PLHYISWLVGHEGKGSILSFLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYE 584
Query: 384 HVNEIIISTFQYLEMLKVTLPEEWIHNELKSTSVSSFKFKQKDPPSSTVSNMARCLEKEY 443
H E+ + F YL+ML+ PE+ I E++ + F ++++ P V NM C +
Sbjct: 585 HFYEVAYTVFLYLKMLQKLGPEKRIFEEIRKIEDNEFHYQEQTDPVEYVENM--CENMQL 642
Query: 444 IPVVDILS-TSLIREYNPSMIKKYVQSLNWENSR-IMLTGQNL-PVDCKEQWYGTEYKVT 500
P+ DIL+ L+ EY P +I + + L + + ++L+G N D KE+W+GT+Y +
Sbjct: 643 YPLQDILTGDQLLFEYKPEVIGEALNQLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIE 702
Query: 501 DYPESLLKKL-PNVGLNPKFHLPRPNEFICTKFEVNKLDNVKPLDEPFLLKDDHYSKLWY 559
D S + N LNP HLP N++I T F + D + P + + LWY
Sbjct: 703 DIENSWAELWNSNFELNPDLHLPAENKYIATDFTLKAFD-CPETEYPVKIVNTPQGCLWY 761
Query: 560 KKDDRFWVPKGHIYVSMKLPHTFSSVVNSMLTSLYVDMIKDALVDLQYDASCADLRITLG 619
KKD++F +PK +I + P S N +L ++V+++ L + Y+A A L L
Sbjct: 762 KKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLA 821
Query: 620 KTNQGIDIQASGYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPYNQ 679
G+ I+ G+N KL +L ++ + F + F +I +L + N P
Sbjct: 822 AGEHGLIIRVKGFNHKLPLLFQLIIDYLAEFNSTPAVFTMITEQLKKTYFNILIK-PETL 880
Query: 680 ISNVFNSLVNERSWTTKAKLDVTKD-LTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAYE 738
+V ++ W+ K D L+ E L SFV QLF E LV GN + + +
Sbjct: 881 AKDVRLLILEYARWSMIDKYQALMDGLSLESLLSFVKEFKSQLFVEGLVQGNVTSTESMD 940
Query: 739 INQLVDILVVDRIPNLEVKNNKLRSYILPEESAFRYEYMLE--DKANVNSCIQYLIQLGA 796
+ VVD++ ++ + + E + + ++ +K + NS + Q G
Sbjct: 941 FLK----YVVDKLNFKPLEQEMPVQFQVVELPSGHHLCKVKALNKGDANSEVTVYYQSGT 996
Query: 797 YSEELAAKASLVSQLIHEPCFDTLRTKEQLGYIVFSAVANTHGTTNLRVLVQSER---DS 853
S L+ + EPCFD LRTK+ LGY V+ NT G V V ++ +S
Sbjct: 997 RSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNS 1056
Query: 854 AYVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNLLQKLTNLRQEYDRFTTAIYLADY 913
V+ +I +FL+SF E ++ + EEAF + LIK + T+L +E DR + Y
Sbjct: 1057 EVVDKKIEEFLSSFEEKIENLTEEAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQY 1116
Query: 914 NFCSYQRRADIITKLSKEDMVEFYKNFVLSPRSSRLAIHL-------------KSQIEKK 960
F + + SK D+V ++K P S L++H+ S +
Sbjct: 1117 LFDRLAHEIEALKSFSKSDLVNWFKAH-RGPGSKMLSVHVVGYGKYELEEDGSPSSEDSN 1175
Query: 961 STEEVVE--GFPTGTL-------ISDIDEFKSNLFLAPVRQAVK 995
S+ EV++ PT L I+DI F + L L P + VK
Sbjct: 1176 SSCEVMQLTYLPTSPLLADCIIPITDIRAFTTTLNLLPYHKIVK 1219
>7292708 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1077
Score = 348 bits (894), Expect = 2e-95
Identities = 242/870 (27%), Positives = 423/870 (47%), Gaps = 53/870 (6%)
Query: 90 VNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYF 149
++ GSF +P GLAHF EH++FMG+EKYP EN + + + K GG +NA T ++T +YF
Sbjct: 100 IDYGSFAEPTKYQGLAHFLEHMIFMGSEKYPKENIFDAHIKKCGGFANANTDCEDTLFYF 159
Query: 150 HLNHENLYPALDRFSGFFSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNW 209
+ ++L +LD F+ PL + + +E +AVDSE ++ LQ+D R QL SL
Sbjct: 160 EVAEKHLDSSLDYFTALMKAPLMKQEAMQRERSAVDSEFQQILQDDETRRDQLLASLATK 219
Query: 210 EHPYHKFSTGNIKTLGDIPKLKGIDIRNELLDFHKNNYSANLMKLCVLGREDLDTLADWV 269
P+ F+ GN+K+L + + ++ L + K +Y AN M +C+ R +D L V
Sbjct: 220 GFPHGTFAWGNMKSLKE--NVDDAELHKILHEIRKEHYGANRMYVCLQARLPIDELESLV 277
Query: 270 YELFKDVPNLNKQVPYYPARLYTESQL----KKMVYCKPVKDLKKIEFTFPTPDMDPYWE 325
F +P+ + P + Y ++ +++ + KPV++ K+E T+ P++ Y+
Sbjct: 278 VRHFSGIPHNEVKAPDLSSFNYKDAFKAEFHEQVFFVKPVENETKLELTWVLPNVRQYYR 337
Query: 326 SKPNHYLSHLIGHEGNGSLLAFLKEKGWAVELSAG----SHTISKDNAVFGIEIDLTDDG 381
SKP+ +LS+L+G+EG GSL A+L+ + WA++L AG ++ ++F I I LTD+G
Sbjct: 338 SKPDQFLSYLLGYEGRGSLCAYLRRRLWALQLIAGIDENGFDMNSMYSLFNICIYLTDEG 397
Query: 382 MNHVNEIIISTFQYLEMLKVTLPEEWIHNELKSTSVSSFKFKQKDPPSSTVSNMARCLEK 441
+++E++ +TF Y+++ + ++ E + + F+F + P V + L
Sbjct: 398 FKNLDEVLAATFAYVKLFANCGSMKDVYEEQQRNEETGFRFHAQRPAFDNVQELV--LNL 455
Query: 442 EYIPVVDILS-TSLIREYNPSMIKKYVQSLNWENSRIMLTGQN-----LPVDCKEQWYGT 495
+Y P DIL+ L EYN +K+ + LN +M+T + D E+W+GT
Sbjct: 456 KYFPPKDILTGKELYYEYNEEHLKELISHLNEMKFNLMVTSRRKYDDISAYDKTEEWFGT 515
Query: 496 EYKVTDYPESLLKKLPNVGLNPKFHLPRPNEFICTKFEV--NKLDNVKPLDEPFLLKDDH 553
EY PE K + P+ LP N+++ F + + + + D P LL
Sbjct: 516 EYATIPMPEKWRKLWEDSVPLPELFLPESNKYVTDDFTLHWHSMGRPEVPDSPKLLIKTD 575
Query: 554 YSKLWYKKDDRFWVPKGHIYVSMKLPHTFSSVVNSMLTSLYVDMIKDALVDLQYDASCAD 613
+LW+++DD+F +P+ H+ P + N + SLY +M++ + + Y A A
Sbjct: 576 TCELWFRQDDKFDLPEAHMAFYFISPMQRQNAKNDAMCSLYEEMVRFHVCEELYPAISAG 635
Query: 614 LRITLGKTNQGIDIQASGYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQY 673
L +L +G+ ++ GYNEKL +++ EG+ + + +N L + NQ+
Sbjct: 636 LSYSLSTIEKGLLLKVCGYNEKLHLIVEAIAEGMLNVAE-----TLDENMLSAFVKNQR- 689
Query: 674 DVPYNQISNVFNSLVNERS--------------WTTKAKLDVTKDLTFEHLKSFVPTIYE 719
FN+L+ ++ W K + E ++ F +
Sbjct: 690 -------KAFFNALIKPKALNRDIRLCVLERIRWLMINKYKCLSSVILEDMREFAHQFPK 742
Query: 720 QLFHESLVLGNFSVEMAYEI-NQLVDILVVDRIPNLEVKNNKLRSYILPEESAFRYEYML 778
+L+ +SL+ GN++ E A+ + N L+ L +I + + S R +
Sbjct: 743 ELYIQSLIQGNYTEESAHNVMNSLLSRLNCKQIRERGRFLEDITVKLPVGTSIIRCHAL- 801
Query: 779 EDKANVNSCIQYLIQLGAYSEELAAKASLVSQLIHEPCFDTLRTKEQLGYIVFSAVANTH 838
+ + N+ I Q+G + + + L+ + EP FD LRTKEQLGY V + V +
Sbjct: 802 -NVQDTNTVITNFYQIGPNTVRVESILDLLMMFVDEPLFDQLRTKEQLGYHVGATVRLNY 860
Query: 839 GTTNLRVLVQSERDSA---YVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNLLQKLT 895
G ++V S+ YVE RI F + L+ +P++ +E + LIK L
Sbjct: 861 GIAGYSIMVNSQETKTTADYVEGRIEVFRAKMLQILRHLPQDEYEHTRDSLIKLKLVADL 920
Query: 896 NLRQEYDRFTTAIYLADYNFCSYQRRADII 925
L E R I Y F +R+ ++I
Sbjct: 921 ALSTEMSRNWDEIINESYLFDRRRRQIEVI 950
>CE01818 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 745
Score = 310 bits (795), Expect = 6e-84
Identities = 149/371 (40%), Positives = 228/371 (61%), Gaps = 1/371 (0%)
Query: 53 LKPDLDDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLL 112
+K D +KYR ++L N L+ LL+S V +G DP LPGLAHFCEH+L
Sbjct: 18 VKGSQDTKKYRGLELTNGLRVLLVSDSKTRVSAVALDVKVGHLMDPWELPGLAHFCEHML 77
Query: 113 FMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCPLF 172
F+G KYP E +Y +L+ + G SNAYT + +TNY F + E LY ALDRF+ FF P F
Sbjct: 78 FLGTAKYPSEREYFKYLAANNGDSNAYTDTDHTNYSFEVRSEKLYGALDRFAQFFLDPQF 137
Query: 173 NKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKG 232
+++T++E+ AV+ E + D WR Q+++SL+ H Y KF+ GN KTL + P+ KG
Sbjct: 138 TESATEREVCAVNCEYLDKVNEDFWRCLQVERSLSKPGHDYSKFAIGNKKTLLEDPRTKG 197
Query: 233 IDIRNELLDFHKNNYSANLMKLCVLGREDLDTLADWVYEL-FKDVPNLNKQVPYYPARLY 291
I+ R+ LLDF+KN YS+++M C++G+E LD L ++ F + N K+ + +
Sbjct: 198 IEPRDVLLDFYKNWYSSDIMTCCIVGKESLDVLESYLGSFKFDAIKNTRKERKIWKDSPF 257
Query: 292 TESQLKKMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLAFLKEK 351
QL K + P+++ ++ FP PD++ + S+P Y++HLIGHEG GSLL+ LK
Sbjct: 258 GPDQLAKRIEIVPIQNTGQVSIKFPFPDLNGEFLSQPGDYIAHLIGHEGPGSLLSELKRL 317
Query: 352 GWAVELSAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEEWIHNE 411
GW + L A +HTI+ VF + +DL+ +G+ HV+++I F ++ LK + P++WIH+E
Sbjct: 318 GWVISLEADNHTIASGFGVFSVTMDLSTEGLEHVDDVIQLVFNFIGFLKSSGPQKWIHDE 377
Query: 412 LKSTSVSSFKF 422
L + F+F
Sbjct: 378 LAELNAVDFRF 388
Score = 115 bits (288), Expect = 3e-25
Identities = 81/345 (23%), Positives = 156/345 (44%), Gaps = 9/345 (2%)
Query: 600 DALVDLQYDASCADLRITLGKTNQGIDIQASGYNEKLTILLTRFLEGIKSFQPKESRFNV 659
D +++ Y+A A L ++ G+ I+ GY+EK ++ + + +FQ F++
Sbjct: 391 DTIIEETYNARLAGLECQFESSSSGVQIRVFGYDEKQSLFAKHLVNRMANFQVNRLCFDI 450
Query: 660 IKNRLLQKLSNQQYDVPYNQISNVFNSLVNERSWTTKAKLDVTKDLTFEHLKSFVPTIYE 719
L + L+N + P++ ++ + LV + W+ + L V +T E + F + +
Sbjct: 451 SFESLKRTLTNHAFSQPHDLSAHFIDLLVVDNIWSKEQLLAVCDSVTLEDVHGFAIKMLQ 510
Query: 720 QLFHESLVLGNF----SVEMAYEINQLVDILVVDRIPNLEVKNNKLRSYILPEESAFRYE 775
E V GN +++++ E++ ++ + + P ++N R L Y
Sbjct: 511 AFHMELFVHGNSTEKDTLQLSKELSDILKSVAPNSRPLKRDEHNPHRELQLINGHEHVYR 570
Query: 776 YMLEDKANVNSCIQYLIQLGAYSEELAAKASLVSQLIHEPCFDTLRTKEQLGYIVFSAVA 835
+ K + C++ Q+G S + L+++LI P + LRT E LGY V +
Sbjct: 571 HF--QKTHDVGCVEVAFQIGVQSTYNNSVNKLLNELIKNPAYTILRTNEALGYNVSTESR 628
Query: 836 NTHGTTNLRVLVQSERDSAYVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNLLQKLT 895
G L V+VQ + +V RI FL S E + MP+E F+ + K +
Sbjct: 629 LNDGNVYLHVIVQGPESADHVLERIEVFLESAREEIVAMPQEDFDYQVWAMFK---ENPP 685
Query: 896 NLRQEYDRFTTAIYLADYNFCSYQRRADIITKLSKEDMVEFYKNF 940
L Q + F + I+ YNF + I +++KE+++ F+ +
Sbjct: 686 TLSQCFSMFWSEIHSRQYNFGRNKEVRGISKRITKEEVINFFDRY 730
>ECU06g0750 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 882
Score = 238 bits (606), Expect = 5e-62
Identities = 224/866 (25%), Positives = 375/866 (42%), Gaps = 87/866 (10%)
Query: 58 DDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLLFMGNE 117
D +Y Y+++PN ++AL++S V +GSF DP GLAHF EH+LFMG E
Sbjct: 23 DTTRYEYVEIPNGMRALIMSDPGLDKCSCAVSVRVGSFDDPADAQGLAHFLEHMLFMGTE 82
Query: 118 KYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCPLFNKAST 177
KYP E+ S FLSK+ G NA T + T YYF + E A+D F+ FF PL + S
Sbjct: 83 KYPVEDGLSYFLSKNNGGYNATTYGEATVYYFDVRPEAFEEAVDMFADFFKSPLLKRDSV 142
Query: 178 DKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRN 237
++E++AV+SE L ND WR +++ K E KFSTGN T L+ I
Sbjct: 143 EREVSAVNSEFCNGLNNDGWRTWRMMKKCCKKEQALSKFSTGNYDT------LRRDGIWE 196
Query: 238 ELLDFHKNNYSANLMKLCVLGREDLDTLADWVYELFKDVPNLNKQVPYYPA--------- 288
E+ +F YS++ M + + G + L + + + F+ VP + +
Sbjct: 197 EMKEFWSRKYSSDKMCVVIYGNKSPGELKELLGK-FEGVPKGHGEDSCDKKDRKCRLDEG 255
Query: 289 -RLYTESQLKKMVYCKPVKDLKKIEFTFPTPDMDPYWESKPNHYLSHLIGHEGNGSLLAF 347
++ E + + +P+ D + I +++ P Y+ ++I +
Sbjct: 256 WSVFDEEYTNRWIRIQPIADTRSIMVMMTVESGYKMFKNNPYEYVLNMILRNDSKGFACK 315
Query: 348 LKEKGWAVELSAGSHTISKDNAVFGIEIDLTDDGMNHVNEIIISTFQYLEMLKVTLPEEW 407
+K+ G +E+ G D +V I + L+ G E ++ +YL+ + V L E
Sbjct: 316 VKDMGLVLEVE-GDLCDYTDYSVMIITMHLSAAGNKRPKEAVLELVKYLKTMPVCLDE-- 372
Query: 408 IHNELKSTSVSSFKFKQKDPPSSTVSNMARCLEKEYIPVVDILS-TSLIREYNPSMIKKY 466
+ EL+ S FK+ +KD P +A + ++ PV ++L ++ I+
Sbjct: 373 -YAELQKRSRYLFKYDEKDDPMYQTRRVA--VNMQFYPVENVLDHEHCFERFDGDEIRGV 429
Query: 467 VQSL----NWENSRIMLTGQNLPVDCKEQWYGTEYKVTDYPESLLKKLPNVGLNPKFHLP 522
V + W I D +E+ YG Y V D + +
Sbjct: 430 VLLMADFSRWVVFHIAKDAGTF--DMREEIYGVRYGVGD------------RIFEAEDID 475
Query: 523 RPNEFICTKFEVNKLDNVKPLDEPFLLKDDHYSKLWYKKDDRFWVPKGHIYVSMKLPHTF 582
N + E + P D L K+ K+ Y +D + VPK ++ ++
Sbjct: 476 AENSGVVEWKEGEMIRTEIPSD--ILTKELPGGKISYLFNDSYKVPKVFAGYLIRTENSS 533
Query: 583 SSVVNSMLTSLYVDMIKDALVDLQYDASC--ADLRITLGKTNQGIDIQASGYNEKLTILL 640
S VVN M + KD +YD S + I + ++G++I+ +N +++ +
Sbjct: 534 SDVVNMMFLARNA---KDQFFK-RYDGSLYKTGVEIDVRVESRGVEIRIECFNH-MSVEV 588
Query: 641 TRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQYDVPYNQISN------VFNSLVNERSWT 694
+R I +P SR ++IK + +L ++ PY + + V L+ E +
Sbjct: 589 SRMFFDILFGEPDGSRRHLIKEEIWNELEVKRTSNPYKRCRDGMKWMKVPGHLMAEEAME 648
Query: 695 TKAKLDVTKDLTFEHLKSFVPTIYEQLFHESLVLGNFSVEMAYEINQLVDILVVDRIPNL 754
+D L+ + F E V+GN A ++ + V +
Sbjct: 649 RLDSVDTKSRLS------------RKFFLEMFVVGNIEYSDAEKMFRHV-------LTKQ 689
Query: 755 EVKNNKLRSYILPEESAFRYEYMLEDKANVNSCIQYLIQLGAYSEELAAKASLVSQLIHE 814
E ++ R+ +L + +R + D+ N + Y G Y K V+ L+H
Sbjct: 690 EEIHSCGRNELL--DGRYRCDINTCDERNNACALSY--YCGRYGNH---KDVAVAHLVHH 742
Query: 815 PC----FDTLRTKEQLGYIVFSAVANTHGTTNLRVLVQSERDSAYVESRIVKFLNSFGEA 870
C FD LRTKE+LGY+V S V + +VQSE+D ++E RI +F+
Sbjct: 743 SCKAMFFDQLRTKEELGYVVISNVTYIDDEQYITFVVQSEKDVEFLEKRIRRFVEELEGY 802
Query: 871 LKEMPEEAFEKHKSGLIKNLLQKLTN 896
KEM E FEK KSG+I + ++ N
Sbjct: 803 FKEMSLEDFEKFKSGVISSFRERKKN 828
>7296373 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 908
Score = 211 bits (537), Expect = 5e-54
Identities = 133/433 (30%), Positives = 227/433 (51%), Gaps = 44/433 (10%)
Query: 54 KPDLDDRKYRYIQLPNNLKALLISXXXXXX----------------------XXXXXXVN 91
K D D + YR + L N L+A+LIS V
Sbjct: 42 KSDGDSKLYRALTLSNGLRAMLISDSYIDEPSIHRASRESLNSSTENFNGKLAACAVLVG 101
Query: 92 IGSFQDPEHLPGLAHFCEHLLFMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHL 151
+GSF +P+ GLAHF EH++FMG+EK+P EN++ SF++K GG SNA+T ++ T +YF L
Sbjct: 102 VGSFSEPQQYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFEL 161
Query: 152 NHENLYPALDRFSGFFSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEH 211
+ +L +D F PL + +E +AV SE ++ D R Q+ SL + +
Sbjct: 162 DQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLASEGY 221
Query: 212 PYHKFSTGNIKTLGDIPKLKGID---IRNELLDFHKNNYSANLMKLCVLGREDLDTLADW 268
P+ FS GN KTL + G+D + EL F++++Y +N M + + + LD L +
Sbjct: 222 PHGTFSWGNYKTLKE-----GVDDSSLHKELHKFYRDHYGSNRMVVALQAQLSLDELEEL 276
Query: 269 VYELFKDVPNLNK------QVPYYPARLYTESQLKKMVYCKPVKDLKKIEFTFPTPDMDP 322
+ D+P + Q+ Y A + + K + +PV+D+ K+E T+ P M
Sbjct: 277 LVRHCADIPTSQQNSIDVSQLNYQKA--FRDQFYKDVFLVQPVEDVCKLELTWVLPPMKN 334
Query: 323 YWESKPNHYLSHLIGHEGNGSLLAFLKEKGWAVELSAGSHTISKDN----AVFGIEIDLT 378
++ SKP+ ++S LIG+EG GSL A+L+ W + + AG S D+ ++F I I L+
Sbjct: 335 FYRSKPDMFISQLIGYEGVGSLCAYLRHHLWCISVVAGVAESSFDSNSIYSLFNICIYLS 394
Query: 379 DDGMNHVNEIIISTFQYLEMLKVTLPEEWIHNELKSTSVSSFKFKQKDPPSSTVSNMARC 438
DDG +H++E++ +TF +++++ + + + E + ++F+F+ + PP V ++
Sbjct: 395 DDGFDHIDEVLEATFAWVKLIINSDQLQDSYKESQQIENNNFRFQIEPPPIDHVQSIVES 454
Query: 439 LEKEYIPVVDILS 451
Y+P D+L+
Sbjct: 455 F--NYLPSKDVLT 465
Score = 104 bits (260), Expect = 6e-22
Identities = 91/387 (23%), Positives = 186/387 (47%), Gaps = 18/387 (4%)
Query: 607 YDASCADLRITLGKTNQGIDIQASGYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQ 666
Y A A L L ++G+ ++ SGYNEKL +L+ L +++ + + N K+ +
Sbjct: 478 YPALEAGLTYGLYIGDKGLVMRVSGYNEKLPLLVEIILNMMQTIELDIGQVNAFKDLKKR 537
Query: 667 KLSNQQYDVPYNQISNVFNSLVNERSWTTKAKLDVTKDLTFEHLKSFVPTIYEQLFHESL 726
++ N + + + L N+R ++ +K + D+T + +KSF +++++ + L
Sbjct: 538 QIYNALINGKSLNLDLRLSILENKR-FSMISKYESVDDITMDDIKSFKENFHKKMYVKGL 596
Query: 727 VLGNFSVEMAYEINQ-LVDILVVDRIPNLEVKNNKLRSYILPEESAF-RYEYMLEDKANV 784
+ GNF+ + A ++ Q ++D +++ NL +N L +P S + R + + ED +
Sbjct: 597 IQGNFTEDQATDLMQKVLDTYKSEKLDNLSALDNHLLQ--IPLGSYYLRAKTLNEDDS-- 652
Query: 785 NSCIQYLIQLGAYSEELAAKASLVSQLIHEPCFDTLRTKEQLGYIVFSAVANTHGTTNLR 844
N+ I Q+G ++ LV ++ EP F+ LRT+EQLGY + +G
Sbjct: 653 NTIITNYYQIGPSDLKMECIMDLVELIVEEPFFNQLRTQEQLGYSLGIHQRIGYGVLAFL 712
Query: 845 VLV---QSERDSAYVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNLLQKLTNLRQEY 901
+ + +++ + YVE RI F + E + +M + F+ + LI T+L +E
Sbjct: 713 ITINTQETKHRADYVEQRIEAFRSRMAELVSQMSDTEFKNIRETLINGKKLGDTSLDEEV 772
Query: 902 DRFTTAIYLADYNFCSYQRRADIITKLSKEDMVEFYKNFVLSPRSSRLAIHLKSQI---E 958
R + I +Y F + + +++ L+KED++ F L+ L Q+
Sbjct: 773 LRNWSEIVTKEYFFNRIETQIQMLSHLTKEDVLNF-----LNDNDKNNLRKLSVQVVGNH 827
Query: 959 KKSTEEVVEGFPTGTLISDIDEFKSNL 985
+++ + +G+L +D+ + N+
Sbjct: 828 NQTSNSTAQASRSGSLSDLLDDVQDNM 854
>YPR122w [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1208
Score = 149 bits (375), Expect = 3e-35
Identities = 80/234 (34%), Positives = 128/234 (54%), Gaps = 7/234 (2%)
Query: 50 SEFLKPDLDDRKYRYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCE 109
S ++ +R ++ +LPN + AL+IS V GS DP+ + GLAH CE
Sbjct: 12 SFYIPLSYSNRTHKVCKLPNGILALIISDPTDTSSSCSLTVCTGSHNDPKDIAGLAHLCE 71
Query: 110 HLLFM-GNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYFHL-----NHENLYPA-LDR 162
H++ G++KYPD + + ++K+ GS NA+T + T +YF L N E + + LD
Sbjct: 72 HMILSAGSKKYPDPGLFHTLIAKNNGSQNAFTTGEQTTFYFELPNTQNNGEFTFESILDV 131
Query: 163 FSGFFSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIK 222
F+ FF PLFN KEI A+ SE++ N+ + Y + L N +HP+ +FSTGNI
Sbjct: 132 FASFFKEPLFNPLLISKEIYAIQSEHEGNISSTTKIFYHAARILANPDHPFSRFSTGNIH 191
Query: 223 TLGDIPKLKGIDIRNELLDFHKNNYSANLMKLCVLGREDLDTLADWVYELFKDV 276
+L IP+LK I +++ L + +NN+ + LC+ G + ++ L F D+
Sbjct: 192 SLSSIPQLKKIKLKSSLNTYFENNFFGENITLCIRGPQSVNILTKLALSKFGDI 245
>CE16673 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 301
Score = 110 bits (276), Expect = 8e-24
Identities = 86/288 (29%), Positives = 139/288 (47%), Gaps = 19/288 (6%)
Query: 720 QLFH-ESLVLGNFSVEMAYEINQ-LVDILVVDRIPNLEVKNNKLRSYILPEE----SAFR 773
Q FH E LV GN + + ++++ L+DIL + + N+ +IL E +
Sbjct: 3 QAFHLELLVYGNSTEKETIQLSKDLIDILKSAAPSSRPLFRNE---HILRREIQLNNGDE 59
Query: 774 YEYMLEDKANVNSCIQYLIQLGAYSEELAAKASLVSQLIHEPCFDTLRTKEQLGYIVFSA 833
Y Y + C+Q Q+G + A L+ LI EP FDTLRTKE LGYIV++
Sbjct: 60 YIYRHLQTTHDVGCVQVTYQIGVQNTYDNAVIGLIKNLITEPAFDTLRTKESLGYIVWTR 119
Query: 834 VANTHGTTNLRVLVQSERDSAYVESRIVKFLNSFGEALKEMPEEAFEKHKSGLIKNLLQK 893
GT L++LVQ + +V RI FL S + + EMP+E FE SGLI L +K
Sbjct: 120 THFNCGTVALQILVQGPKSVDHVLERIEAFLESVRKEIVEMPQEEFENRVSGLIAQLEEK 179
Query: 894 LTNLRQEYDRFTTAIYLADYNFCSYQRRADIITKLSKEDMVEFYKNFVLSPRSSR----L 949
L + +F I YNF + +++ + KED++ + + + R +
Sbjct: 180 PKTLSCRFKKFWDEIECRQYNFTRIEEDVELLKTIKKEDVIALFDKKIRKGAAERRKLAV 239
Query: 950 AIHLKSQIEKKSTEEVVEGFPTGTLISDIDEFKSNLFLAPVRQAVKQY 997
+H KS+ ++ + E+++ + D + K L+L +RQ + Y
Sbjct: 240 IVHGKSE-DRAAVNEIIKKH-----LEDGKKKKEVLYLDQLRQFLPLY 281
>YLR163c [O] KOG0960 Mitochondrial processing peptidase beta subunit and
related enzymes (insulinase superfamily)
Length = 462
Score = 64.3 bits (155), Expect = 9e-10
Identities = 54/224 (24%), Positives = 90/224 (40%), Gaps = 12/224 (5%)
Query: 63 RYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDE 122
R +LPN L V+ GS + G AHF EHL F G + +
Sbjct: 27 RTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTAHFLEHLAFKGTQNRSQQ 86
Query: 123 NDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCPLFNKASTDKEIN 182
+ G NAYT +NT YY E++ A+D S + + + ++ ++E +
Sbjct: 87 G-IELEIENIGSHLNAYTSRENTVYYAKSLQEDIPKAVDILSDILTKSVLDNSAIERERD 145
Query: 183 AV--DSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRNELL 240
+ +SE + +++ ++ +T + P + G IK + I R +L
Sbjct: 146 VIIRESEEVDKMYDEV--VFDHLHEITYKDQPLGRTILGPIKNIKSI-------TRTDLK 196
Query: 241 DFHKNNYSANLMKLCVLGREDLDTLADWVYELFKDVPNLNKQVP 284
D+ NY + M L G D + L + + F VP VP
Sbjct: 197 DYITKNYKGDRMVLAGAGAVDHEKLVQYAQKYFGHVPKSESPVP 240
>At3g02090 [O] KOG0960 Mitochondrial processing peptidase beta subunit and
related enzymes (insulinase superfamily)
Length = 531
Score = 56.6 bits (135), Expect = 2e-07
Identities = 53/239 (22%), Positives = 97/239 (40%), Gaps = 13/239 (5%)
Query: 63 RYIQLPNNLKALLISXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDE 122
R LPN L+ S ++ GS + + G AHF EH++F G ++
Sbjct: 98 RVTTLPNGLRVATESNLSAKTATVGVWIDAGSRFESDETNGTAHFLEHMIFKGTDR-RTV 156
Query: 123 NDYSSFLSKHGGSSNAYTGSQNTNYYFHLNHENLYPALDRFSGFFSCPLFNKASTDKEIN 182
+ GG NAYT + T YY + N+ ALD + F + ++E +
Sbjct: 157 RALEEEIEDIGGHLNAYTSREQTTYYAKVLDSNVNQALDVLADILQNSKFEEQRINRERD 216
Query: 183 AVDSENKK-NLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRNELLD 241
+ E ++ Q D + L + +++ LG +K I R +L +
Sbjct: 217 VILREMQEVEGQTD-------EVVLDHLHATAFQYTPLGRTILGPAQNVKSI-TREDLQN 268
Query: 242 FHKNNYSANLMKLCVLGREDLDTLADWVYELFKDV---PNLNKQVPYYPARLYTESQLK 297
+ K +Y+A+ M + G + + + V +LF + P Q+ +T S+++
Sbjct: 269 YIKTHYTASRMVIAAAGAVKHEEVVEQVKKLFTKLSSDPTTTSQLVANEPASFTGSEVR 327
>At3g57460 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 356
Score = 56.2 bits (134), Expect = 2e-07
Identities = 33/115 (28%), Positives = 60/115 (51%), Gaps = 2/115 (1%)
Query: 558 WYKKDDRFWVPKGHIYVSMKLPHTFSSVVNSMLTSLYVDMIKDALVDLQYDASCADLRIT 617
WY ++ + K I + P SS +L++ V ++ D L + Y A A L
Sbjct: 174 WYNTAEK--IIKFTIQMDFNCPLAVSSPATVVLSNSSVWLLVDYLNEYAYYAQAARLHYG 231
Query: 618 LGKTNQGIDIQASGYNEKLTILLTRFLEGIKSFQPKESRFNVIKNRLLQKLSNQQ 672
L ++ G ++ +G+N KL ILL ++ + +FQ K RF+V+K +L++L ++
Sbjct: 232 LSLSDNGFELSLTGFNHKLRILLEAVIQKMANFQVKPDRFSVVKVTVLRELKKEE 286
>At5g42390 [O] KOG0959 N-arginine dibasic convertase NRD1 and related
Zn2+-dependent endopeptidases insulinase superfamily
Length = 1265
Score = 53.1 bits (126), Expect = 2e-06
Identities = 56/215 (26%), Positives = 98/215 (45%), Gaps = 24/215 (11%)
Query: 66 QLPNNLKALLI-SXXXXXXXXXXXXVNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDEND 124
QL N L+ L++ + V++GS + E G+AH EH+ F+G++K
Sbjct: 199 QLKNGLRYLILPNKVPPNRFEAHMEVHVGSIDEEEDEQGIAHMIEHVAFLGSKK------ 252
Query: 125 YSSFLSKHGGSSNAYTGSQNTNYYFHL------NHENLYPA-LDRFSGFFSCPLFNKAST 177
L G SNAYT +T ++ H + ++L+P+ LD + P F +
Sbjct: 253 -REKLLGTGARSNAYTDFHHTVFHIHSPTHTKDSEDDLFPSVLDALNEIAFHPKFLSSRV 311
Query: 178 DKEINAVDSENKKNLQNDIWRMYQLDKSLTNWEHPYHKFSTGNIKTLGDIPKLKGIDIRN 237
+KE A+ SE + N I Y++D L H +K G +G ++K D+ +
Sbjct: 312 EKERRAILSE--LQMMNTI--EYRVDCQLLQHLHSENKL--GRRFPIGLEEQIKKWDV-D 364
Query: 238 ELLDFHKNNYSANLMKLCVLGREDLDTLADWVYEL 272
++ FH+ Y L ++G D+D + V+ +
Sbjct: 365 KIRKFHERWYFPANATLYIVG--DIDNIPRIVHNI 397
>Hs4758734 [O] KOG0960 Mitochondrial processing peptidase beta subunit and
related enzymes (insulinase superfamily)
Length = 489
Score = 51.2 bits (121), Expect = 8e-06
Identities = 51/210 (24%), Positives = 89/210 (42%), Gaps = 11/210 (5%)
Query: 90 VNIGSFQDPEHLPGLAHFCEHLLFMGNEKYPDENDYSSFLSKHGGSSNAYTGSQNTNYYF 149
++ GS + E G AHF EH+ F G +K + D + G NAYT + T YY
Sbjct: 85 IDAGSRYENEKNNGTAHFLEHMAFKGTKK-RSQLDLELEIENMGAHLNAYTSREQTVYYA 143
Query: 150 HLNHENLYPALDRFSGFFSCPLFNKASTDKEINAVDSENKKNLQNDIWRMYQLDKSLTNW 209
++L A++ + +A ++E + E ++ N L + + ++
Sbjct: 144 KAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETN-------LQEVVFDY 196
Query: 210 EHPYHKFSTGNIKT-LGDIPKLKGIDIRNELLDFHKNNYSANLMKLCVLGREDLDTLADW 268
H +T +T LG +K I R +L+D+ +Y + L G D L D
Sbjct: 197 LHATAYQNTALGRTILGPTENIKSIS-RKDLVDYITTHYKGPRIVLAAAGGVSHDELLDL 255
Query: 269 VYELFKDVPNLNK-QVPYYPARLYTESQLK 297
F D +K ++P P +T S+++
Sbjct: 256 AKFHFGDSLCTHKGEIPALPPCKFTGSEIR 285
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,209,666
Number of Sequences: 60738
Number of extensions: 2759098
Number of successful extensions: 7108
Number of sequences better than 1.0e-05: 22
Number of HSP's better than 0.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 6992
Number of HSP's gapped (non-prelim): 33
length of query: 1004
length of database: 30,389,216
effective HSP length: 116
effective length of query: 888
effective length of database: 23,343,608
effective search space: 20729123904
effective search space used: 20729123904
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)