ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1474 good TU KOG0998 Intracellular trafficking, secretion, and vesicular transport Synaptic vesicle protein EHS-1 and related EH domain proteins
r_klactV1474 good TU KOG0998 Signal transduction mechanisms Synaptic vesicle protein EHS-1 and related EH domain proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1474 515081 518764 1228
(1228 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBL047c [TU] KOG0998 Synaptic vesicle protein EHS-1 and related ... 730 0.0
SPBC800.10c [TU] KOG0998 Synaptic vesicle protein EHS-1 and rela... 214 9e-55
Hs10864047 [TU] KOG0998 Synaptic vesicle protein EHS-1 and relat... 125 3e-28
SPBC83.01 [TU] KOG0998 Synaptic vesicle protein EHS-1 and relate... 113 2e-24
Hs4503593 [TU] KOG0998 Synaptic vesicle protein EHS-1 and relate... 93 2e-18
7291848 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related ... 92 5e-18
Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin 84 2e-15
7298751 [TU] KOG1029 Endocytic adaptor protein intersectin 83 2e-15
CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin 79 4e-14
CE02903 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related ... 78 1e-13
YIR006c [TU] KOG0998 Synaptic vesicle protein EHS-1 and related ... 63 3e-09
Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin 61 1e-08
7296991 [DY] KOG0977 Nuclear envelope protein lamin intermediate... 61 1e-08
HsM7657054 [TU] KOG1954 Endocytosis/signaling protein EHD1 60 3e-08
Hs21361462 [TU] KOG1954 Endocytosis/signaling protein EHD1 60 3e-08
7297819 [U] KOG1955 Ral-GTPase effector RALBP1 59 4e-08
At1g21630 [TU] KOG0998 Synaptic vesicle protein EHS-1 and relate... 58 8e-08
CE28509 [TU] KOG1954 Endocytosis/signaling protein EHD1 58 1e-07
CE25148 [TU] KOG1954 Endocytosis/signaling protein EHD1 58 1e-07
CE25147 [TU] KOG1954 Endocytosis/signaling protein EHD1 58 1e-07
CE25146 [TU] KOG1954 Endocytosis/signaling protein EHD1 58 1e-07
Hs15313972 [Z] KOG0161 Myosin class II heavy chain 57 1e-07
Hs13124879 [Z] KOG0161 Myosin class II heavy chain 57 1e-07
Hs13124875 [Z] KOG0161 Myosin class II heavy chain 57 1e-07
At1g20760 [TU] KOG0998 Synaptic vesicle protein EHS-1 and relate... 57 1e-07
Hs4758200 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific prote... 56 3e-07
YKR092c [Y] KOG2992 Nucleolar GTPase/ATPase p130 55 5e-07
Hs18578080 [TU] KOG1954 Endocytosis/signaling protein EHD1 54 1e-06
7299673 [TU] KOG1954 Endocytosis/signaling protein EHD1 54 2e-06
Hs21264315 [TU] KOG1954 Endocytosis/signaling protein EHD1 54 2e-06
7291892 [Z] KOG0161 Myosin class II heavy chain 54 2e-06
Hs7657056 [TU] KOG1954 Endocytosis/signaling protein EHD1 53 3e-06
Hs5803009 [TU] KOG1954 Endocytosis/signaling protein EHD1 53 3e-06
Hs20532997 [Z] KOG0161 Myosin class II heavy chain 52 6e-06
CE09349 [Z] KOG0161 Myosin class II heavy chain 52 6e-06
Hs12667788 [Z] KOG0161 Myosin class II heavy chain 52 8e-06
CE04618 [Z] KOG0161 Myosin class II heavy chain 52 8e-06
>YBL047c [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 1381
Score = 730 bits (1884), Expect = 0.0
Identities = 505/1441 (35%), Positives = 720/1441 (49%), Gaps = 273/1441 (18%)
Query: 1 MSGIAFRVPLTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICD 60
M+ I FR PL+S+E+ ++Q F +LD E LG+VTGEA+RPLF+ SGL Q LSQ+W D
Sbjct: 1 MASITFRTPLSSQEQAFYNQKFHQLDTEDLGVVTGEAVRPLFASSGLPGQLLSQVWATVD 60
Query: 61 TENAGFLTVDQFNAALRMVAHLQENPGAQVTLELYQTPASKLPSFGQSQKFNSASTQPSI 120
+N GFL +++F+AALRM+A LQ P ++ LY++ ++L SF
Sbjct: 61 IDNKGFLNLNEFSAALRMIAQLQNAPNQPISAALYESTPTQLASF--------------- 105
Query: 121 PPPSNQSHSVQRVPSVINRSVSRTNTGSSPTYSVIPVCTPHDYAKFAQLFDRSTEESGFL 180
S+ + P+ + + NT ++ IP + +D AKF+QLFDR+ + + +
Sbjct: 106 --------SINQNPAPMQSGSATGNTNNTD----IPALSSNDIAKFSQLFDRTAKGAQTV 153
Query: 181 AGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLP 240
AG+KA++IFLKA+LP QTLG IW LCDR SG LDK EF+MAM+LIQL + + ++ P
Sbjct: 154 AGDKAKDIFLKARLPNQTLGEIWALCDRDASGVLDKSEFIMAMYLIQLCMSHHPSMNTPP 213
Query: 241 STLPNYLWXXXXXXXXXXXXXXXXXNXXXXXXXXXXXVVRNPGIIRKPSLSRLPSGTFSN 300
+ LP LW N + R ++SRL +G FSN
Sbjct: 214 AVLPTQLWDSIRLEPVVV-------NQPNRTTPLSANSTGVSSLTRHSTISRLSTGAFSN 266
Query: 301 AATDWTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLADIHN 360
AA+DW+L+ EKKQQFDAIFDSLDK+ GSL S VLVPFFL+S+L Q+ LAT+WDLADIHN
Sbjct: 267 AASDWSLSFEKKQQFDAIFDSLDKQHAGSLSSAVLVPFFLSSRLNQETLATIWDLADIHN 326
Query: 361 SPVFTKVEFAIAMFLIQKKNAGIELPDVVPDQLLNSPALGLY--------HXXXXXXXXX 412
+ FTK+EFAIAMFLIQKKNAG+ELPDV+P++LL SPALGLY
Sbjct: 327 NAEFTKLEFAIAMFLIQKKNAGVELPDVIPNELLQSPALGLYPPNPLPQQQSAPQIAIPS 386
Query: 413 RISVASTGDAGQ-------NYQNFAAPVQAQKTSNSALDDLLGLNESFTXXXXXXXXXXX 465
R S S D N Q V Q ++N +L+DLL LN SF+
Sbjct: 387 RASKPSLQDMPHQVSAPAVNTQPTVPQVLPQNSNNGSLNDLLALNPSFSSPSPTKAQTVV 446
Query: 466 XXXXXX------------------------THLAPNARKFRPSSTFGQTIIPEEGGNDXX 501
TH + +KF P+S FGQ+II EE
Sbjct: 447 QNNTNNSFSYDNNNGQATLQQQQPQQPPPLTHSSSGLKKFTPTSNFGQSIIKEEPEEQEQ 506
Query: 502 XXXXXXXXXXXYMQTAPTHVGSAAPPPPPTARNSSLPSVPNFGGVSVPSREVTS------ 555
P V A P +++LP VPNF S+P+ TS
Sbjct: 507 LRESSDT-----FSAQPPPVPKHASSPVKRTASTTLPQVPNFSVFSMPAGAATSAATGAA 561
Query: 556 -----------------------NNREIVPP----ASLSQATTELANLSTQVSSLTTQAT 588
N+++ A LS ATTE+ANLS QV+SL+ QA+
Sbjct: 562 VGAAVGAAALGASAFSRSSNNAFKNQDLFADGEASAQLSNATTEMANLSNQVNSLSKQAS 621
Query: 589 KVHEEKTAAQNELTRITNMKASIETKLIGLRASYNEEVRQTEEIQTQLNALRAQNEELSQ 648
+++K+ A EL R+T MK SI+ KL LR+++++ V+QTE+++ Q+ + +NE L+Q
Sbjct: 622 ITNDKKSRATQELKRVTEMKNSIQIKLNNLRSTHDQNVKQTEQLEAQVLQVNKENETLAQ 681
Query: 649 QASVAEANYHAVXXXXXXXXXXXXXXXXXXXXXXXXXXXFNTLSSQLQQQLAEVQENAKA 708
Q +V+EANYHA N++++ LQ QL E Q+ K
Sbjct: 682 QLAVSEANYHAAESKLNELTTDLQESQTKNAELKEQITNLNSMTASLQSQLNEKQQQVKQ 741
Query: 709 ERSRVDIHAKQLELSEMTANNLQTEIQSLEQTLGIYLSKHKELDDYKATIEAQHAEMENK 768
ERS VD+++KQLEL+++T NLQ EI L + + +YL+K KEL+DY+ T+E QHA+++ K
Sbjct: 742 ERSMVDVNSKQLELNQVTVANLQKEIDGLGEKISVYLTKQKELNDYQKTVEEQHAQLQAK 801
Query: 769 HKQYLATSEEVHARELEVQSRTAEIEKQEQLYRDQVSRLQELFNDLNKRKSEFEAANAEF 828
++ ++ RE +++ R +IE+QE LY VS+LQE+F+DL++RK+ FE A+ E
Sbjct: 802 YQDLSNKDTDLTDREKQLEERNRQIEEQENLYHQHVSKLQEMFDDLSQRKASFEKADQEL 861
Query: 829 EKQQYDYADRVQKFSENQMKLAMGETPDD-----------------EYTN---------- 861
+++ +YA+ V++ SE QM LAMG+ P+D E T+
Sbjct: 862 KERNIEYANNVRELSERQMNLAMGQLPEDAKDIIAKSASNTDTTTKEATSRGNVHEDTVS 921
Query: 862 ---ELIQKRLQIQTAQPAEEEEKPE----SVFDKDVPTPVSQTEPXXXXXXXXXXXXXXX 914
E + + + ++EEK E VFD+DVPT SQ++
Sbjct: 922 KFVETTVENSNLNVNRVKDDEEKTERTESDVFDRDVPTLGSQSD-----------SENAN 970
Query: 915 XXXXXXXGNDEV---AAEAMADSFEGSLNEYGIPR----TESVTSSTANNPPQSV----- 962
GN+ E ++D F+G LNEYGIPR T SV ++ + V
Sbjct: 971 TNNGTQSGNETANPNLTETLSDRFDGDLNEYGIPRSQSLTSSVANNAPQSVRDDVELPET 1030
Query: 963 ---RDEVESEPKENAVLDIDQ--------------QLEDAENNDITKQGSETVQPASTDE 1005
RD + + + ++ + E ++ + GS T + S ++
Sbjct: 1031 LEERDTINNTANRDNTGNLSHIPGEWEATPATASTDVLSNETTEVIEDGSTTKRANSNED 1090
Query: 1006 PLPGGWSTGSTLEKDQIS-DSDADSIKKT--PILETQDKVSDAQGAEID-------IPAI 1055
G S S E +IS A +I + PI E SD+ ++ D IP+
Sbjct: 1091 ----GESVSSIQESPKISAQPKAKTINEEFPPIQELHIDESDSSSSDDDEFEDTREIPSA 1146
Query: 1056 QDLKLE---DTQVSSEDEKH-EQV-------------ESSAKNVSSKPDTP--------- 1089
L+ + Q +S E H EQV E ++K S+ P
Sbjct: 1147 TVKTLQTPYNAQPTSSLEIHTEQVIKYPAPGTSPSHNEGNSKKASTNSILPVKDEFDDEF 1206
Query: 1090 ------------------EFVN--------QFEHITHQDLDENVFHDA------SSVQPF 1117
EF N QFE I H+DLD+ + +A SS P
Sbjct: 1207 AGLEQAAVEEDNGADSESEFENVANAGSMEQFETIDHKDLDDELQMNAFTGTLTSSSNPT 1266
Query: 1118 -------DSEESAKAPVGNDEWDEIFSGLGNNGNTIQTSDVPASVTPTPLQHPVPSAGSL 1170
S A V NDEWDEIF+G GN+ ++ TP+ Q P+P
Sbjct: 1267 IPKPQVQQQSTSDPAQVSNDEWDEIFAGFGNS-----KAEPTKVATPSIPQQPIPLKND- 1320
Query: 1171 PL--SSMSKSPI-DRGIAVTPKSLAIEELSSMGFSKEEATKALEKCDWDLDDATNLLLDG 1227
P+ +S+SK PI +RG+A TPKSLA+EELS MGF++EEA ALEKC+WDL+ ATN LLD
Sbjct: 1321 PIVDASLSKGPIVNRGVATTPKSLAVEELSGMGFTEEEAHNALEKCNWDLEAATNFLLDS 1380
Query: 1228 A 1228
A
Sbjct: 1381 A 1381
>SPBC800.10c [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 1116
Score = 214 bits (544), Expect = 9e-55
Identities = 269/1171 (22%), Positives = 462/1171 (38%), Gaps = 181/1171 (15%)
Query: 10 LTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTV 69
L++EE+ AF Q F D++ +G++TGE P +SGL PQ L QIW I D EN GFLT
Sbjct: 5 LSAEEQTAFDQLFKIADKQDIGVITGEEAVPFLEKSGLAPQVLGQIWQIADAENRGFLTF 64
Query: 70 DQFNAALRMVAHLQENPGAQVTLELYQTPASKLPSFGQSQKFNSASTQPSIPPPSNQSHS 129
F A+R+VA QE L + K+P F S S
Sbjct: 65 SGFVIAMRLVALAQEK------LPFDYKKSGKIPYFADIHISGVDS-----------SKF 107
Query: 130 VQRVPSVINRSVSRTNTGSSPTYSVIPVCTPHDYAKFAQLFDRSTEESGFLAGNKAREIF 189
VQ +NR + ++G S +P + + ++ Q+F G + G++A IF
Sbjct: 108 VQ-----LNRP-NNVSSGDGSDGSFLPPISSDEMTRYQQMFTTVCPTDGLMDGDRASSIF 161
Query: 190 LKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLP-STLPNYLW 248
+A L T+ L +W L D G+LD EF MH+I L L N ++++ P S P+++
Sbjct: 162 GRAPLSTEILARVWNLVDTHKRGALDIREFNTGMHIINLLL--NGSLKSPPVSISPSFI- 218
Query: 249 XXXXXXXXXXXXXXXXXNXXXXXXXXXXXVVRNPGIIRKPSLSRLPSGTFSNAATDWTLT 308
+ PG+ R P + + P+ S+ W +
Sbjct: 219 ------------------ASAASTSSVSAPSQYPGLSRSPPV-QAPNIPVSD---PWAIP 256
Query: 309 LEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLADIHNSPVFTKVE 368
+ F +F ++DK KG + + FFL SKL +DVLA +WDL+D +++ E
Sbjct: 257 SQDLTSFCQLFSNVDKAHKGYVSGSEAYSFFLASKLPEDVLAQIWDLSDTNSNGKLNIGE 316
Query: 369 FAIAMFLIQKKNAGIELPDVVPDQLLNSPALGLYHXXXXXXXXXRISVASTGDAGQNYQN 428
F I+++LI+ K +G ELP V+P +L+S A + + A+ N
Sbjct: 317 FCISLYLIKLKLSGKELPKVLPSSMLSSVAPLMQKSKSVPTSIPSVVPANISSPNPNPTL 376
Query: 429 FAAPVQAQKTSNSALDDLLGLNESFTXXXXXXXXXXXXXXXXXTHLAPNARKFRPSSTFG 488
P + + S +DLL L+ H AP K P
Sbjct: 377 APNPTGPSRVT-SGTEDLLSLD---ATPFSPTLAPQHTSSNATKHSAPPVTKSAPFPVVS 432
Query: 489 QTIIPEEGGNDXXXXXXXXXXXXXYMQTAPTHVGSAAPPPPPTAR---NSSLPSVPNFGG 545
+ G T+P AA P PT+ SS
Sbjct: 433 PLQLNHTPG----------------FPTSP-----AAKPNSPTSTFFPQSSFGQTIAKNT 471
Query: 546 VSVPSREVTSNNREIVPPASLSQATTELANLSTQVSSLTTQATKVHEEKTAAQNELTRIT 605
+ PS TS ++ P A+ E L+ +V L +Q ++V + Q +
Sbjct: 472 MDKPSAVRTSVPSQLAAPIP-QVASAEQLKLAAEVPKLESQLSQVKKSNDDLQKSSRDVA 530
Query: 606 NMKASIETKLIGLRASYNEEVRQTEEIQTQLNALRAQNEELSQQASVAEANYHAVXXXXX 665
+ ++ K+ +R +Y+EE+ + ++I + +AQ E+++++ S+ EA +A+
Sbjct: 531 ANLSDVKAKVSEIRKAYDEELAKAKQISLDIETNKAQTEQVNREYSILEATLNAL----- 585
Query: 666 XXXXXXXXXXXXXXXXXXXXXXFNTLSSQLQQQLAEVQENAKAERSRVDIHAKQLELSEM 725
+ +Q EV E AE + +E S
Sbjct: 586 ---------------------------QKQNKQKGEVLEQVVAES---EAAKNMVESSNA 615
Query: 726 TANNLQTEIQSLEQTLG-IYLSKHK------ELDDYKATIEAQHAEME---NKHKQYLAT 775
+ L++E+ EQTL ++L + LD+ + + ++E N K LAT
Sbjct: 616 SIQQLKSEVADKEQTLAQLHLQLDEMTQRLVSLDEESKAVSQRKLDLEYKINNSKTQLAT 675
Query: 776 SEEVHARELEVQSRTAEIEKQEQLYRDQVSRLQELFNDLNKRKSEFEAANAEFEKQQYDY 835
+ E E S+ E EKQE +S+L++ +N E K + D
Sbjct: 676 ATE----EYHEHSKQLEAEKQE------LSKLEDGLKSVN--------LTEEAPKPEVDS 717
Query: 836 ADRVQKFSENQMKLAMGETPDDEYTNELIQKRLQIQTAQPAEEEEKPESVFDKDVPTPVS 895
R F+ N + PD ++ P + FD T S
Sbjct: 718 TPRFPSFTSNGITTDKPTLPD-------------TTSSVPTQHNS-----FDAMHNTLRS 759
Query: 896 QTEPXXXXXXXXXXXXXXXXXXXXXXGNDEVAAEAMADSFEGSLNEYGIPRTESVTSSTA 955
+ G A+ +++ +E PR+ S T+S +
Sbjct: 760 PSLNSNNSSAHASTVSRNPFHNLKISG----ASSPVSNFWESEFASAVFPRSISKTTSLS 815
Query: 956 NNPPQSVRDEVESEPKENAVLDIDQQLEDAENNDITKQGSETVQPASTD-EPLPGGWSTG 1014
N SV ++SEP + + ++ + Q +D+ D++ S+ P +D L G S
Sbjct: 816 VN-NSSVNPSLDSEPVQLSNME-EPQHQDSSVVDVSTSASQRGSPVLSDLSKLTG--SAR 871
Query: 1015 STLEKDQISDSDADSIKKTPILETQDKVSDAQGAEIDIPAIQDLKLEDTQVSSEDE-KHE 1073
+T E + ++ A+ I+ T T ++++ Q A I A + T +
Sbjct: 872 NTAE--PVENTSAEPIENTS-APTPFEIANKQQATEPISAPFATETISTPAPVKPPVPPS 928
Query: 1074 QVESSAKNVSSKPDTPEFVNQFEHITHQDLDENVFHDASSVQPFDSEESAKAPVGN-DEW 1132
+ + SA++ + TP ++F I ++D++ +S +P S S + +G+ +
Sbjct: 929 RRDRSAQDGVVQQATPHIQDEFPPIQFNEIDDD--ESSSDEEPPMSNLSPQISIGSVTNY 986
Query: 1133 DEIFSGLGNNGNTIQTSDVPASVTPTPLQHP 1163
+ L + + ++ S T T +QHP
Sbjct: 987 TSAVTELPDPNHQLEMS------TTTHVQHP 1011
>Hs10864047 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 864
Score = 125 bits (315), Expect = 3e-28
Identities = 103/380 (27%), Positives = 160/380 (42%), Gaps = 43/380 (11%)
Query: 18 FSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTVDQFNAALR 77
+ ++ ++D G V +SGL+ L +IW + D E GFL F ALR
Sbjct: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Query: 78 MVAHLQENPGAQVTLELYQTPASKLPSFGQSQKFNSASTQPSIPPPSNQSHSVQRVPSVI 137
+VA Q G +VTL S L KF+ S+ + PPS ++H RV
Sbjct: 79 LVACAQS--GHEVTL-------SNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRV---- 125
Query: 138 NRSVSRTNTGSSPTYSVIPVCTPHDYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQ 197
+ AKF +F+ +G L+G+K + + + +KLP
Sbjct: 126 -----------------------EEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLD 162
Query: 198 TLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLPSTL--PNYLWXXXXXXX 255
LG +W L D G LD+ EF +AMHL+ L++ LP +L P+
Sbjct: 163 VLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGA 222
Query: 256 XXXXXXXXXXNXXXXXXXXXXXVVRNPGIIRKPSLSRLPSGTFSNAATDWTLTLEKKQQF 315
V + SLS S + +W + + K +F
Sbjct: 223 VPVLPASPPPKDSLRSTPSHGSV---SSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRF 279
Query: 316 DAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLADIHNSPVFTKVEFAIAMFL 375
D IF D + G + + F+ S L Q++LA +W LAD + +K +FA+AM+
Sbjct: 280 DEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYF 339
Query: 376 IQKK-NAGIELPDVV-PDQL 393
IQ+K + GI+ P V+ PD +
Sbjct: 340 IQQKVSKGIDPPQVLSPDMV 359
Score = 78.2 bits (191), Expect = 8e-14
Identities = 69/229 (30%), Positives = 109/229 (47%), Gaps = 27/229 (11%)
Query: 13 EEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTVDQF 72
EEK F F L G+++G+ ++P+ S L L ++W + D + G L D+F
Sbjct: 126 EEKAKFDGIFESLLPIN-GLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEF 184
Query: 73 NAALRMVAHLQENPGAQVTLELYQTPASKLPSFGQSQKFNSA-STQPSIPPPSNQSHSVQ 131
A+ +V E L P+ PS + F A P+ PPP + S++
Sbjct: 185 AVAMHLVYRALEKEPVPSALP----PSLIPPSKRKKTVFPGAVPVLPASPPPKD---SLR 237
Query: 132 RVPSVINRSVSRTN-TGS-SPTYS----------VIPVCTPHDYAKFAQLFDRSTEE-SG 178
PS + SVS N TGS SP +S V+PV D +F ++F ++ + G
Sbjct: 238 STPS--HGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVA---DKMRFDEIFLKTDLDLDG 292
Query: 179 FLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQ 227
+++G + +EIF+ + L L IW L D +G L K +F +AM+ IQ
Sbjct: 293 YVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQ 341
Score = 69.3 bits (168), Expect = 3e-11
Identities = 57/219 (26%), Positives = 88/219 (40%), Gaps = 41/219 (18%)
Query: 177 SGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQ-QNAA 235
+G + ++A K+ L LG IW L D G LDK F +A+ L+
Sbjct: 31 TGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVT 90
Query: 236 VQNLPSTLPNYLWXXXXXXXXXXXXXXXXXNXXXXXXXXXXXVVRNPGIIRKPSLSRLPS 295
+ NL ++P + +P ++ PS
Sbjct: 91 LSNLNLSMPPPKFHDTS----------------------------SPLMVTPPS------ 116
Query: 296 GTFSNAATDWTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDL 355
A W + +E+K +FD IF+SL G L + + P + SKL DVL VWDL
Sbjct: 117 -----AEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKVKPVLMNSKLPLDVLGRVWDL 170
Query: 356 ADIHNSPVFTKVEFAIAMFLIQKKNAGIELPDVVPDQLL 394
+DI + EFA+AM L+ + +P +P L+
Sbjct: 171 SDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLI 209
>SPBC83.01 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 884
Score = 113 bits (283), Expect = 2e-24
Identities = 108/463 (23%), Positives = 177/463 (37%), Gaps = 70/463 (15%)
Query: 10 LTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTV 69
L+ E+Q F + L EQ ++ G + P + GL + L++IW CD E+ G L
Sbjct: 6 LSPIEQQEFDRLLESLHPEQKDLIPGSVIGPFLLKFGLPQKILAKIWDYCDQEDKGSLDR 65
Query: 70 DQFNAALRMVAHLQENPGAQVTLELYQTPASKLPSFGQSQKFNSASTQPSIPPPSNQSHS 129
+Q A R+++ Q GA + Q +N A P +P + H
Sbjct: 66 NQVYACFRLISQAQR--GATL----------------QELDYNKAGDPPILPKQAKDDHH 107
Query: 130 VQRVPSVINRSVSRTNTGSSPTYSVIPVCTPHDYAKFAQLFD---RSTEES---GFLAGN 183
++R S + T + IP+ P + +++ + F R E+S G + +
Sbjct: 108 IKR---------SSSETADFTPFR-IPI-NPDERSEYEKEFRENLRGHEDSARPGCMPSS 156
Query: 184 KAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLPSTL 243
A+ I LK+ L L IW L D ++ G L+ ++V+A HL+ + Q N + +LP +L
Sbjct: 157 IAKPILLKSSLHYAVLAQIWNLADSAHVGYLEMYQYVIARHLVAICKQYN--LIHLPRSL 214
Query: 244 PNYLWXXXXXXXXXXXXXXXXXNXXXXXXXXXXXVVRNPGIIRKPSLSRLPSGTFSNAAT 303
P N +V + + S+S S +
Sbjct: 215 P-------ADVIESAKSETPAMNTNIEQGVTQPSLVNTEQLSHQQSISSTKSSKLDEISA 267
Query: 304 D-------------------------WTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPF 338
D +T E + F +F +D E KG + VPF
Sbjct: 268 DNNAQSAVDNKYSSPPQTIDPQANIKALITPEDRSNFYQLFSKIDNENKGYIVGGEAVPF 327
Query: 339 FLTSKLGQDVLATVWDLADIHNSPVFTKVEFAIAMFLIQKKNAGIELPDVVP-DQLLNSP 397
F+ S L + LA +WD D + K EFA+AM +I+ + +G L ++ D P
Sbjct: 328 FMASHLDSEELARIWDTVDTQDRGYIDKDEFAVAMEIIKLRLSGKSLASILAYDDNPTEP 387
Query: 398 ALGLYHXXXXXXXXXRISVASTGDAGQNYQNFAAPVQAQKTSN 440
+ + VA T D N A + T N
Sbjct: 388 TMQQNLVSDDTNASTAVPVAFTNDNVSNVPLSVADNEPNSTLN 430
Score = 87.4 bits (215), Expect = 1e-16
Identities = 62/251 (24%), Positives = 114/251 (44%), Gaps = 28/251 (11%)
Query: 6 FRVPLTSEEKQAFSQHF-----SRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICD 60
FR+P+ +E+ + + F D + G + +P+ +S L L+QIW + D
Sbjct: 121 FRIPINPDERSEYEKEFRENLRGHEDSARPGCMPSSIAKPILLKSSLHYAVLAQIWNLAD 180
Query: 61 TENAGFLTVDQFNAALRMVAHLQE----NPGAQVTLELYQTPASKLPSFGQSQKFNSAST 116
+ + G+L + Q+ A +VA ++ + + ++ ++ S+ P+ + T
Sbjct: 181 SAHVGYLEMYQYVIARHLVAICKQYNLIHLPRSLPADVIESAKSETPAMNTN--IEQGVT 238
Query: 117 QPSIPPPSNQSHS----------VQRVPSVINRSVSRTNTGSSPTYSVIP------VCTP 160
QPS+ SH + + + N + N SSP ++ P + TP
Sbjct: 239 QPSLVNTEQLSHQQSISSTKSSKLDEISADNNAQSAVDNKYSSPPQTIDPQANIKALITP 298
Query: 161 HDYAKFAQLFDR-STEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEF 219
D + F QLF + E G++ G +A F+ + L ++ L IW D + G +DK EF
Sbjct: 299 EDRSNFYQLFSKIDNENKGYIVGGEAVPFFMASHLDSEELARIWDTVDTQDRGYIDKDEF 358
Query: 220 VMAMHLIQLTL 230
+AM +I+L L
Sbjct: 359 AVAMEIIKLRL 369
>Hs4503593 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 896
Score = 93.2 bits (230), Expect = 2e-18
Identities = 64/232 (27%), Positives = 101/232 (42%), Gaps = 35/232 (15%)
Query: 12 SEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTVDQ 71
S + +++ ++D G V +SGL L +IW + DT+ G L +
Sbjct: 13 SSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQE 72
Query: 72 FNAALRMVAHLQENPGAQVTLELYQTPASKLPSFGQSQKFNSASTQPSIPPPSNQSHSVQ 131
F ALR+VA Q G +V+L +S ++PPP S
Sbjct: 73 FFVALRLVACAQN--GLEVSL---------------------SSLNLAVPPPRFHDTSSP 109
Query: 132 RVPSVINRSVSRTNTGSSPTYSVIPVCTPHDYAKFAQLFDRSTEESGFLAGNKAREIFLK 191
+ +S T+ P P D AK+ +FD + +GFL+G+K + + L
Sbjct: 110 LL-------ISGTSAAELPW-----AVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLN 157
Query: 192 AKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLPSTL 243
+KLP LG +W L D + G LD+ EF +AM L+ L++ +LP L
Sbjct: 158 SKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPAL 209
Score = 77.4 bits (189), Expect = 1e-13
Identities = 68/228 (29%), Positives = 96/228 (41%), Gaps = 44/228 (19%)
Query: 163 YAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMA 222
Y K+ + D T +G + + A K+ LP LG IW L D G L+K EF +A
Sbjct: 19 YEKYYRQVD--TGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVA 76
Query: 223 MHLIQLTLQQNAAVQNLPSTLPNYLWXXXXXXXXXXXXXXXXXNXXXXXXXXXXXVVRNP 282
+ L+ QN +L S + P
Sbjct: 77 LRLVACA--QNGLEVSLSSL----------------------------------NLAVPP 100
Query: 283 GIIRKPSLSRLPSGTFSNAATDWTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTS 342
S L SGT S A W + E K ++DAIFDSL G L + + P L S
Sbjct: 101 PRFHDTSSPLLISGT-SAAELPWAVKPEDKAKYDAIFDSLSPVN-GFLSGDKVKPVLLNS 158
Query: 343 KLGQDVLATVWDLADIHNSPVFTKVEFAIAMFLI----QKKNAGIELP 386
KL D+L VW+L+DI + + + EFA+AMFL+ +K+ + LP
Sbjct: 159 KLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLP 206
Score = 73.9 bits (180), Expect = 1e-12
Identities = 60/219 (27%), Positives = 96/219 (43%), Gaps = 53/219 (24%)
Query: 13 EEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTVDQF 72
E+K + F L G ++G+ ++P+ S L L ++W + D ++ G L D+F
Sbjct: 127 EDKAKYDAIFDSLSPVN-GFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEF 185
Query: 73 NAALRMVAHLQENPGAQVTLELYQTPASKLPSFGQSQKFNSASTQPSIPPPSNQSHSVQR 132
A+ +V LE P S LP P++ PPS +
Sbjct: 186 AVAMFLV---------YCALEKEPVPMS-LP--------------PALVPPSKRK----- 216
Query: 133 VPSVINRSVSRTNTGSSPTYSVIPVCTPHDYAKFAQLFDRSTEE-SGFLAGNKAREIFLK 191
T+ V +P + AK+ ++F ++ ++ GF++G + REIFLK
Sbjct: 217 ------------------TW----VVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLK 254
Query: 192 AKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTL 230
LP+ L IW LCD + G L K +F +A HLI L
Sbjct: 255 TGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKL 293
>7291848 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 668
Score = 92.0 bits (227), Expect = 5e-18
Identities = 71/227 (31%), Positives = 107/227 (46%), Gaps = 31/227 (13%)
Query: 18 FSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTVDQFNAALR 77
+ ++ +D + G + +SGL+ LS+IW + D GFL F AL+
Sbjct: 16 YEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALK 75
Query: 78 MVAHLQENPGAQVTLELYQTPASKLPSFGQSQKFNSASTQPSIPPPSNQSHSVQRVPSVI 137
+V+ Q A + +Y A+ P G+ K T PS +Q VP V
Sbjct: 76 LVSLSQAGQVASMA-NIYLDIANP-PKLGELPK-----TMPS---------RIQTVP-VA 118
Query: 138 NRSVSRTNTGSSPTYSVIPVCTPHDYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQ 197
+ V+ + + VI D K+ QLF+ +G L GNK + + + +KLP
Sbjct: 119 SGGVANGDW----SIGVI------DRLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMS 168
Query: 198 TLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLPSTLP 244
LGTIW L D+ G+LD EFV+AMHL+ TLQ+ + +PS LP
Sbjct: 169 ILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQK----RTIPSVLP 211
Score = 62.0 bits (149), Expect = 6e-09
Identities = 64/246 (26%), Positives = 101/246 (41%), Gaps = 48/246 (19%)
Query: 157 VCTPHD--YAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSL 214
VC H Y + +L D + +G + A + K+ L L IW L D S G L
Sbjct: 8 VCGKHIGVYEAYYKLID--PKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFL 65
Query: 215 DKVEFVMAMHLIQLTLQ-QNAAVQNLPSTLPNYLWXXXXXXXXXXXXXXXXXNXXXXXXX 273
DK F +A+ L+ L+ Q A++ N+ YL
Sbjct: 66 DKPGFFVALKLVSLSQAGQVASMANI------YL-------------------------- 93
Query: 274 XXXXVVRNP---GIIRKPSLSRL---PSGTFSNAATDWTLTLEKKQQFDAIFDSLDKEKK 327
+ NP G + K SR+ P + A DW++ + + +++ +F+SL
Sbjct: 94 ----DIANPPKLGELPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQLFESLHPSN- 148
Query: 328 GSLGSNVLVPFFLTSKLGQDVLATVWDLADIHNSPVFTKVEFAIAMFLIQKKNAGIELPD 387
G L N + + SKL +L T+WDLAD EF +AM L+ + +P
Sbjct: 149 GMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRTIPS 208
Query: 388 VVPDQL 393
V+P +L
Sbjct: 209 VLPPEL 214
Score = 61.2 bits (147), Expect = 1e-08
Identities = 57/247 (23%), Positives = 107/247 (43%), Gaps = 43/247 (17%)
Query: 24 RLDREQL--------GIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTVDQFNAA 75
RL EQL G++ G ++ + S L L IW + D + G L + +F A
Sbjct: 134 RLKYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVA 193
Query: 76 LRMV--------------AHLQENPGAQVTLELYQTP---ASKLPSFGQSQKFNSA---- 114
+ +V L++ GA + P + +P + F
Sbjct: 194 MHLVYQTLQKRTIPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVA 253
Query: 115 ------STQPSIPPPSNQSHSVQRVP---SVINRSVSRTNT----GSSPTYSVIPVCTPH 161
+ +IPP + R+P +V ++ + +T+ G+ + V TP
Sbjct: 254 NFPKDIAPPAAIPPLPVAVPPMTRIPPVGAVSSQPLIQTDPLIPIGAPVMANADWVVTPA 313
Query: 162 DYAKFAQLFDRST-EESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFV 220
D +F ++F +S ++ G ++G + ++IF+K+ +P ++L IW LCD + SG L +F
Sbjct: 314 DLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFA 373
Query: 221 MAMHLIQ 227
+AM ++
Sbjct: 374 LAMWFVE 380
Score = 58.5 bits (140), Expect = 6e-08
Identities = 30/97 (30%), Positives = 51/97 (51%)
Query: 293 LPSGTFSNAATDWTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATV 352
+P G A DW +T ++F+ IF D +K G + + F+ S + Q LA +
Sbjct: 296 IPIGAPVMANADWVVTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADI 355
Query: 353 WDLADIHNSPVFTKVEFAIAMFLIQKKNAGIELPDVV 389
W L D + S T +FA+AM+ +++K G++ P V+
Sbjct: 356 WALCDTNQSGKLTVEQFALAMWFVERKQRGVDPPHVL 392
Score = 57.4 bits (137), Expect = 1e-07
Identities = 34/138 (24%), Positives = 64/138 (45%), Gaps = 4/138 (2%)
Query: 10 LTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTV 69
+T + + F + F + D ++ G+V+G ++ +F +SG+ + L+ IW +CDT +G LTV
Sbjct: 310 VTPADLKRFEEIFRQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTV 369
Query: 70 DQFNAALRMVAHLQENPGAQVTLELYQTPASKLPSFG----QSQKFNSASTQPSIPPPSN 125
+QF A+ V Q L P S + Q Q+ + P + S
Sbjct: 370 EQFALAMWFVERKQRGVDPPHVLNANMVPPSMRATVAGVDLQPQEVKPTYSNPELEMISK 429
Query: 126 QSHSVQRVPSVINRSVSR 143
+ + R V+ +++
Sbjct: 430 EIEELARERRVLETEIAQ 447
>Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1221
Score = 83.6 bits (205), Expect = 2e-15
Identities = 77/289 (26%), Positives = 124/289 (42%), Gaps = 59/289 (20%)
Query: 10 LTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTV 69
+T EE+ Q F L + G +TG+ R F QSGL L+QIW + D N G +
Sbjct: 17 ITVEERAKHDQQFHSL-KPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQ 75
Query: 70 DQFNAALRMVAH--------------LQENPGAQVTLELY---------------QTPAS 100
+F+ A++++ +++ P A + + P
Sbjct: 76 VEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPPFGMGGIASMPPLTAVAPVPMG 135
Query: 101 KLPSFGQSQKFNSASTQPSIPPPSNQSHSV-QRVPSVIN--------RSVSRTNTGS--- 148
+P G S S+ ++PP +N + V Q +P+ + S SR+ GS
Sbjct: 136 SIPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLN 195
Query: 149 -----SPTYSVIPVCTPHDYA-------KFAQLFDRSTEE-SGFLAGNKAREIFLKAKLP 195
+ ++ V V ++A K+ QLF+ + SG L G +AR I +++ LP
Sbjct: 196 TKLQKAQSFDVASVPPVAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLP 255
Query: 196 TQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLPSTLP 244
L +IW L D G L EF++AMHLI + + + Q LP LP
Sbjct: 256 QAQLASIWNLSDIDQDGKLTAEEFILAMHLIDVAM----SGQPLPPVLP 300
Score = 65.5 bits (158), Expect = 5e-10
Identities = 37/86 (43%), Positives = 48/86 (55%), Gaps = 4/86 (4%)
Query: 159 TPHDYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVE 218
T + AK Q F SGF+ G++AR F ++ LP L IW L D +N G +D+VE
Sbjct: 18 TVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVE 77
Query: 219 FVMAMHLIQLTLQQNAAVQNLPSTLP 244
F +AM LI+L LQ LPS LP
Sbjct: 78 FSIAMKLIKLKLQG----YQLPSALP 99
Score = 63.2 bits (152), Expect = 3e-09
Identities = 37/100 (37%), Positives = 54/100 (54%), Gaps = 1/100 (1%)
Query: 298 FSNAATDWTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLAD 357
F + W +T+E++ + D F SL K G + + FF S L Q VLA +W LAD
Sbjct: 8 FGGSLDIWAITVEERAKHDQQFHSL-KPISGFITGDQARNFFFQSGLPQPVLAQIWALAD 66
Query: 358 IHNSPVFTKVEFAIAMFLIQKKNAGIELPDVVPDQLLNSP 397
++N +VEF+IAM LI+ K G +LP +P + P
Sbjct: 67 MNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQP 106
Score = 52.0 bits (123), Expect = 6e-06
Identities = 28/91 (30%), Positives = 45/91 (48%)
Query: 304 DWTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLADIHNSPV 363
+W + + ++ +F+S DK G L + S L Q LA++W+L+DI
Sbjct: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
Query: 364 FTKVEFAIAMFLIQKKNAGIELPDVVPDQLL 394
T EF +AM LI +G LP V+P + +
Sbjct: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYI 304
>7298751 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 83.2 bits (204), Expect = 2e-15
Identities = 64/266 (24%), Positives = 107/266 (40%), Gaps = 36/266 (13%)
Query: 159 TPHDYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVE 218
TP + K+ + F ++GF+ G +A+ FL+++LP LG IW L D + G ++ E
Sbjct: 11 TPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINE 70
Query: 219 FVMAMHLIQLTLQQNAAVQNLPSTLPNYLWXXXXXXXXXXXXXXXXXNXX---------- 268
F +A LI L L+ ++P LP L +
Sbjct: 71 FSIACKLINLKLRG----MDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVP 126
Query: 269 --------XXXXXXXXXVVRNPGII--------------RKPSLSRLPSGTFSNAATDWT 306
V+ PG+ R S+S S +W
Sbjct: 127 AVAPVVPVVAPPVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWA 186
Query: 307 LTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLADIHNSPVFTK 366
+ +K+++ +F++ D+ + G L + + SKL Q LA +W L+DI
Sbjct: 187 VQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNC 246
Query: 367 VEFAIAMFLIQKKNAGIELPDVVPDQ 392
EF +AMFL +K AG ++P +P +
Sbjct: 247 DEFILAMFLCEKAMAGEKIPVTLPQE 272
Score = 79.3 bits (194), Expect = 3e-14
Identities = 70/266 (26%), Positives = 114/266 (42%), Gaps = 36/266 (13%)
Query: 10 LTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTV 69
+T E+ + + F L + Q G VTG + F QS L P L QIW + DT++ G + +
Sbjct: 10 VTPRERLKYQEQFRAL-QPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNI 68
Query: 70 DQFNAALRMVAHLQENPGAQVTL--ELYQTPASKLPSFGQSQKFNSAS------------ 115
++F+ A +++ L L + +PS +S S
Sbjct: 69 NEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAV 128
Query: 116 --TQPSIPPP-------SNQSHSVQRVPSVINRSVSRTNTGSSPTYSVIPVCTPHDYA-- 164
P + PP S SV P+ + +T S I ++A
Sbjct: 129 APVVPVVAPPVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQ 188
Query: 165 -----KFAQLFDRSTE-ESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVE 218
K+ Q+F+ + SG+L G++AR + +++KLP TL IW L D G L+ E
Sbjct: 189 AAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDE 248
Query: 219 FVMAMHLIQLTLQQNAAVQNLPSTLP 244
F++AM L + + A + +P TLP
Sbjct: 249 FILAMFLCEKAM----AGEKIPVTLP 270
>CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 79.0 bits (193), Expect = 4e-14
Identities = 68/260 (26%), Positives = 106/260 (40%), Gaps = 38/260 (14%)
Query: 162 DYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVM 221
+Y K +F + T F+ AR +++ LPTQ L IW L D G LD E+ +
Sbjct: 11 EYQKNFAMFGQLTGGQPFMDAVTARNALMRSNLPTQVLSQIWALSDLDKDGRLDIREYSI 70
Query: 222 AMHLIQLTLQQNAAVQNLPSTLPNYLWXXXXXXXXXXXXXXXXXNXXXXXXXXXXXVVRN 281
AM +L L A + +P LP L +
Sbjct: 71 AM---RLALNCLAGIP-IPPQLPPSLLVVPARNAPPTWPGSRHGSVDYSQTLP------- 119
Query: 282 PGIIRKPSLSRLPSGTFSNAAT---------------------------DWTLTLEKKQQ 314
P I R+ S S +PS S A T +W + K +
Sbjct: 120 PAIDRRMSQSYIPSAPVSIAGTPSSRHNSISAGSPLNNDRNVFEGRQLENWAIPHHNKLK 179
Query: 315 FDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLADIHNSPVFTKVEFAIAMF 374
+ +F++LDKE+ GSL S V S L +VLA +W L+D++ + E+AI+ +
Sbjct: 180 YSQLFNALDKERLGSLSSQVGRSALGLSGLPTNVLAHIWFLSDVNKDGKLSVDEYAISQY 239
Query: 375 LIQKKNAGIELPDVVPDQLL 394
+I+ +G LP + P +L+
Sbjct: 240 MIEMFKSGFALPKITPLELV 259
Score = 60.1 bits (144), Expect = 2e-08
Identities = 55/213 (25%), Positives = 90/213 (41%), Gaps = 27/213 (12%)
Query: 39 RPLFSQSGLTPQQLSQIWTICDTENAGFLTVDQFNAALRMVAH-LQENP-GAQVTLELYQ 96
R +S L Q LSQIW + D + G L + +++ A+R+ + L P Q+ L
Sbjct: 35 RNALMRSNLPTQVLSQIWALSDLDKDGRLDIREYSIAMRLALNCLAGIPIPPQLPPSLLV 94
Query: 97 TPASKLPSFGQSQKFNSASTQPSIPPPSNQSHSVQRVPSVINRSVSRTNTGSSPTYSVIP 156
PA P + S ++PP ++ S +PS VS T SS ++ I
Sbjct: 95 VPARNAPPTWPGSRHGSVDYSQTLPPAIDRRMSQSYIPSA---PVSIAGTPSS-RHNSIS 150
Query: 157 VCTP--------------------HDYAKFAQLFDRSTEES-GFLAGNKAREIFLKAKLP 195
+P H+ K++QLF+ +E G L+ R + LP
Sbjct: 151 AGSPLNNDRNVFEGRQLENWAIPHHNKLKYSQLFNALDKERLGSLSSQVGRSALGLSGLP 210
Query: 196 TQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQL 228
T L IW L D + G L E+ ++ ++I++
Sbjct: 211 TNVLAHIWFLSDVNKDGKLSVDEYAISQYMIEM 243
>CE02903 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 751
Score = 77.8 bits (190), Expect = 1e-13
Identities = 60/201 (29%), Positives = 88/201 (42%), Gaps = 15/201 (7%)
Query: 52 LSQIWTICDTENAGFLTVDQFNAALRMVAHLQEN-PGAQVTL--ELYQTP--ASKLPSFG 106
L QIW + D++ G L A ++VA Q+ P A +L Q P A +P
Sbjct: 4 LGQIWELSDSQKVGSLDKRGAFVAFKLVAAAQQGKPVANSSLYDSSLQPPRFAPPVPPAN 63
Query: 107 QSQKFN----SASTQPSIPPPSNQSHSVQRVPSVINRSVSRTNTGSSPTYSVIPVCTPHD 162
F S P +PPP + SH P I+ S SS P+ TP D
Sbjct: 64 MQHHFQPSFPSVGRAPPVPPPPHPSH-----PYSISSQQSSPAHPSSAFPPQWPI-TPTD 117
Query: 163 YAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMA 222
AK+ +F +G L+G R + + + L L IW L D+ G+LD++E +A
Sbjct: 118 QAKYDSIFQSLNPVNGKLSGAHVRPVLMNSGLDAHALARIWELSDQDKDGNLDRIEMSVA 177
Query: 223 MHLIQLTLQQNAAVQNLPSTL 243
+HL+ +LQ + LP L
Sbjct: 178 LHLVYRSLQSDPVPAQLPPNL 198
Score = 62.8 bits (151), Expect = 3e-09
Identities = 67/274 (24%), Positives = 113/274 (40%), Gaps = 44/274 (16%)
Query: 9 PLTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLT 68
P+T ++ + F L+ G ++G +RP+ SGL L++IW + D + G L
Sbjct: 112 PITPTDQAKYDSIFQSLNPVN-GKLSGAHVRPVLMNSGLDAHALARIWELSDQDKDGNLD 170
Query: 69 VDQFNAALRMV-AHLQENP-GAQVTLEL---------YQTP------------------- 98
+ + AL +V LQ +P AQ+ L + +P
Sbjct: 171 RIEMSVALHLVYRSLQSDPVPAQLPPNLIHPSKAMYAHSSPNFAAPPHPPRPMMGSRAGS 230
Query: 99 ASKLPSFGQSQKFNSASTQPSIPPPSNQSHSVQRVPSVINRSVSRTNTGSSPTYSVIPV- 157
+ L SQ + SA+ + PP +++S Q + S + T +S + P
Sbjct: 231 VTSLDDVNMSQSY-SATMPRAYPPQPGRAYSAQAHVNGSRTSGASTPISASHSIHSFPAG 289
Query: 158 ---CTPHDYA-KFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGS 213
DYA +FAQ T + G + G R + L Q L +W L D G
Sbjct: 290 EWPINTGDYADQFAQ---TDTNKDGLVDGMDMRAPMMTTGLSAQILAHVWALADIKKCGQ 346
Query: 214 LDKVEFVMAMHLIQLTLQQNAAVQNLPSTLPNYL 247
L+ +F + MHL+ + + +++PS LP +L
Sbjct: 347 LNLEQFALTMHLLDMAKRG----ESIPSELPLHL 376
>YIR006c [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 1480
Score = 62.8 bits (151), Expect = 3e-09
Identities = 36/106 (33%), Positives = 56/106 (51%), Gaps = 1/106 (0%)
Query: 291 SRLPSGTFSNAATDWTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLA 350
S + N++ D ++ E+K F IF++ D + KG L S V F S L + L
Sbjct: 581 SNFNNNLIDNSSQD-KISTEEKSLFYKIFETFDTQNKGLLDSPTAVEIFRKSGLNRADLE 639
Query: 351 TVWDLADIHNSPVFTKVEFAIAMFLIQKKNAGIELPDVVPDQLLNS 396
+W+L DI+N+ K EFA+ M L+ K G +P+V+P L+ S
Sbjct: 640 QIWNLCDINNTGQLNKQEFALGMHLVYGKLNGKPIPNVLPSSLIPS 685
Score = 61.2 bits (147), Expect = 1e-08
Identities = 50/159 (31%), Positives = 69/159 (42%), Gaps = 9/159 (5%)
Query: 95 YQTPASKLPSFGQSQKFNSASTQPS--IPPPSNQSHSVQRVPSVINRSVSRTNTGSSPTY 152
YQ+ ++P Q+Q Q + P NQ+ P+ S N G +
Sbjct: 197 YQSQPQQVPPPQQAQSLQPLKPQQTGFYLQPQNQAPLEPLKPTATGFVNSFANNGLNNDI 256
Query: 153 SV----IPVCTPHDYAKFAQLFDRS--TEESGFLAGNKAREIFLKAKLPTQTLGTIWGLC 206
+ + T D AKF LF RS T S ++G R+I +++ LP L IW LC
Sbjct: 257 KIPAIRLSFITAQDQAKFETLF-RSIVTNGSNTVSGANCRKILMRSGLPPSQLARIWTLC 315
Query: 207 DRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLPSTLPN 245
D S +G L EF +AMHLI LQ + L S N
Sbjct: 316 DTSKAGELLFPEFALAMHLINDVLQGDTIPYELDSKTKN 354
Score = 55.5 bits (132), Expect = 5e-07
Identities = 59/230 (25%), Positives = 85/230 (36%), Gaps = 29/230 (12%)
Query: 33 VTGEALRP-----LFSQSGLTPQQLSQIWTICDTEN-----AGFLTVDQFNAALRMVAHL 82
+TG AL+P + +G+ PQ + N G Q+ V
Sbjct: 463 ITGNALQPQTTGMMPQTTGMMPQTTGMMPQTSFGVNLGPQLTGGALQSQYTGGYGSVMPQ 522
Query: 83 QENPGAQVTLELYQTPASKLPSFGQSQKFNSASTQPS-IPPPSNQSHSVQRVPS------ 135
Q P + L Q G + QP+ PPSN S ++
Sbjct: 523 QSGPASMPNLSFNQQ--------GLQSQLTGLQPQPTGFLPPSNFSATMPLTAQKTGFGN 574
Query: 136 --VINRSVSRTNTGSSPTYSVIPVCTPHDYAKFAQLFDRSTEESGFLAGNKAREIFLKAK 193
+ +S N + + I + K + FD T+ G L A EIF K+
Sbjct: 575 NEIYTKSNFNNNLIDNSSQDKISTEEKSLFYKIFETFD--TQNKGLLDSPTAVEIFRKSG 632
Query: 194 LPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLPSTL 243
L L IW LCD +N+G L+K EF + MHL+ L LPS+L
Sbjct: 633 LNRADLEQIWNLCDINNTGQLNKQEFALGMHLVYGKLNGKPIPNVLPSSL 682
Score = 52.4 bits (124), Expect = 4e-06
Identities = 28/96 (29%), Positives = 50/96 (51%), Gaps = 2/96 (2%)
Query: 10 LTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTV 69
+T++++ F F + V+G R + +SGL P QL++IWT+CDT AG L
Sbjct: 266 ITAQDQAKFETLFRSIVTNGSNTVSGANCRKILMRSGLPPSQLARIWTLCDTSKAGELLF 325
Query: 70 DQFNAALRMVAHLQENPGAQVTLELYQTPASKLPSF 105
+F A+ ++ + + G + EL +++ SF
Sbjct: 326 PEFALAMHLINDVLQ--GDTIPYELDSKTKNEVSSF 359
>Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1177
Score = 61.2 bits (147), Expect = 1e-08
Identities = 33/86 (38%), Positives = 46/86 (53%), Gaps = 4/86 (4%)
Query: 159 TPHDYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVE 218
T + K + FD G++ G++AR FL++ LP L IW L D + G +D+ E
Sbjct: 30 TSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQE 89
Query: 219 FVMAMHLIQLTLQQNAAVQNLPSTLP 244
F +AM LI+L LQ Q LP LP
Sbjct: 90 FSIAMKLIKLKLQG----QQLPVVLP 111
Score = 56.2 bits (134), Expect = 3e-07
Identities = 34/93 (36%), Positives = 51/93 (54%), Gaps = 1/93 (1%)
Query: 305 WTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLADIHNSPVF 364
W +T E++ + D FD+L K G + + FFL S L VLA +W L+D++
Sbjct: 27 WAITSEERTKHDRQFDNL-KPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 85
Query: 365 TKVEFAIAMFLIQKKNAGIELPDVVPDQLLNSP 397
+ EF+IAM LI+ K G +LP V+P + P
Sbjct: 86 DQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPP 118
Score = 55.5 bits (132), Expect = 5e-07
Identities = 42/126 (33%), Positives = 60/126 (47%), Gaps = 16/126 (12%)
Query: 129 SVQRVPSVINRSVSRTNT------GSSPTYSV----IPVCTPHDYAKFAQLFDRSTEESG 178
S+Q+ S+I+ S + + G+SP +P T Y + D+S SG
Sbjct: 215 SIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSM--SG 272
Query: 179 FLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQN 238
+L+G +AR L++ L L TIW L D G L EF++AMHL + A Q
Sbjct: 273 YLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTDMA----KAGQP 328
Query: 239 LPSTLP 244
LP TLP
Sbjct: 329 LPLTLP 334
Score = 52.0 bits (123), Expect = 6e-06
Identities = 31/106 (29%), Positives = 47/106 (44%)
Query: 289 SLSRLPSGTFSNAATDWTLTLEKKQQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDV 348
S + L + ++W + + ++ F++LDK G L L S L Q
Sbjct: 233 STASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQ 292
Query: 349 LATVWDLADIHNSPVFTKVEFAIAMFLIQKKNAGIELPDVVPDQLL 394
LAT+W LAD+ EF +AM L AG LP +P +L+
Sbjct: 293 LATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELV 338
>7296991 [DY] KOG0977 Nuclear envelope protein lamin intermediate filament
superfamily
Length = 622
Score = 60.8 bits (146), Expect = 1e-08
Identities = 70/338 (20%), Positives = 130/338 (37%), Gaps = 47/338 (13%)
Query: 523 SAAPPPPPTARNSSLPSVPNFGGVSVPSREVTSNNREIVPPASLSQATTELANLSTQVSS 582
SA P PPP + +S S P P+R + + L LA +V +
Sbjct: 25 SAGPQPPPPSTHSQTASSP-----LSPTR-----HSRVAEKVELQNLNDRLATYIDRVRN 74
Query: 583 LTTQATKVHEEKTAAQNELTR-ITNMKASIETKLIGLRASYNEEVRQTEEIQTQLNALRA 641
L T+ +++ E ++ +TR TN+K E +L+ R ++ R + + L
Sbjct: 75 LETENSRLTIEVQTTRDTVTRETTNIKNIFEAELLETRRLLDDTARDRARAEIDIKRLWE 134
Query: 642 QNEEL-------SQQASVAEANYHAVXXXXXXXXXXXXXXXXXXXXXXXXXXXFNTLSSQ 694
+NEEL +++ + AE N N +
Sbjct: 135 ENEELKNKLDKKTKECTTAEGNVRMYESRANELNNKYNQA--------------NADRKK 180
Query: 695 LQQQLAEVQENAKAERSRVDIHAKQLELSEMTANNLQTEIQSLEQTLGIYLSKH-KELDD 753
L + L E + + R + + K LE ++ +L+ IQSL + L H +E+++
Sbjct: 181 LNEDLNEALKELERLRKQFEETRKNLEQETLSRVDLENTIQSLREELSFKDQIHSQEINE 240
Query: 754 YKATIEAQHAEMENKHKQYLATSEEVHARELEVQ-SRTAEIEKQE--QLYRDQVSRLQEL 810
+ + +++E++ + + +EL Q +I + E LY D++ RLQE
Sbjct: 241 SRRIKQTEYSEIDGRLSSEYDAKLKQSLQELRAQYEEQMQINRDEIQSLYEDKIQRLQEA 300
Query: 811 -----------FNDLNKRKSEFEAANAEFEKQQYDYAD 837
+L + +A NA + + AD
Sbjct: 301 AARTSNSTHKSIEELRSTRVRIDALNANINELEQANAD 338
>HsM7657054 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 543
Score = 59.7 bits (143), Expect = 3e-08
Identities = 31/82 (37%), Positives = 43/82 (51%)
Query: 162 DYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVM 221
D +K+ ++F G L+G+KA+ + KLP LG IW L D G LD EF +
Sbjct: 449 DKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFAL 508
Query: 222 AMHLIQLTLQQNAAVQNLPSTL 243
A HLI+ L+ + NLP L
Sbjct: 509 ASHLIEAKLEGHGLPANLPRRL 530
>Hs21361462 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 543
Score = 59.7 bits (143), Expect = 3e-08
Identities = 31/82 (37%), Positives = 43/82 (51%)
Query: 162 DYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVM 221
D +K+ ++F G L+G+KA+ + KLP LG IW L D G LD EF +
Sbjct: 449 DKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFAL 508
Query: 222 AMHLIQLTLQQNAAVQNLPSTL 243
A HLI+ L+ + NLP L
Sbjct: 509 ASHLIEAKLEGHGLPANLPRRL 530
>7297819 [U] KOG1955 Ral-GTPase effector RALBP1
Length = 903
Score = 59.3 bits (142), Expect = 4e-08
Identities = 33/125 (26%), Positives = 64/125 (50%), Gaps = 9/125 (7%)
Query: 10 LTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLTV 69
+T E+++ +++ F + R+ G+++G+A R F +S + ++L IW +CD G L++
Sbjct: 262 ITPEQREYYNKQFRTVQRDPHGLLSGQAARNFFEKSRIPVEELRHIWQLCDVTRDGALSL 321
Query: 70 DQFNAALRMVAHLQENPGAQVTL------ELYQTPASKLPSFGQSQKFNSASTQPSIPPP 123
+F AA+ +V + N +L + Q AS GQ +S++ P PP
Sbjct: 322 SEFTAAMHLVVLRRNNIPLPTSLPHCLHPNVLQAAAS---GSGQGVTSSSSAALPQEPPE 378
Query: 124 SNQSH 128
++ H
Sbjct: 379 ADLLH 383
Score = 53.1 bits (126), Expect = 3e-06
Identities = 29/71 (40%), Positives = 38/71 (52%), Gaps = 1/71 (1%)
Query: 178 GFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQ 237
G L+G AR F K+++P + L IW LCD + G+L EF AMHL+ L
Sbjct: 283 GLLSGQAARNFFEKSRIPVEELRHIWQLCDVTRDGALSLSEFTAAMHLVVLRRNNIPLPT 342
Query: 238 NLPSTL-PNYL 247
+LP L PN L
Sbjct: 343 SLPHCLHPNVL 353
>At1g21630 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 1181
Score = 58.2 bits (139), Expect = 8e-08
Identities = 27/87 (31%), Positives = 50/87 (57%)
Query: 313 QQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLADIHNSPVFTKVEFAIA 372
Q++ +F +D ++ G + N FL+ +L +D L VWDL+D N + + EF IA
Sbjct: 426 QKYTKVFVQVDTDRDGKITGNQARNLFLSWRLPRDALKQVWDLSDQDNDSMLSLREFCIA 485
Query: 373 MFLIQKKNAGIELPDVVPDQLLNSPAL 399
++L+++ G LP V P +++S ++
Sbjct: 486 VYLMERYREGRPLPPVFPSSIIHSESM 512
Score = 57.4 bits (137), Expect = 1e-07
Identities = 40/130 (30%), Positives = 62/130 (46%), Gaps = 11/130 (8%)
Query: 106 GQSQKFNSASTQPSIPPPSN-------QSHSVQRVPSVINRSVSRTNTGSSPTYSVIPVC 158
G S + ++S S PP S S QR P ++ R S P + P
Sbjct: 364 GNSGQPYTSSGAASGPPGSTVGVGISATSQLAQRPPHPHSQPQPRPQGQSQPPW---PKM 420
Query: 159 TPHDYAKFAQLFDR-STEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKV 217
TP D K+ ++F + T+ G + GN+AR +FL +LP L +W L D+ N L
Sbjct: 421 TPADVQKYTKVFVQVDTDRDGKITGNQARNLFLSWRLPRDALKQVWDLSDQDNDSMLSLR 480
Query: 218 EFVMAMHLIQ 227
EF +A++L++
Sbjct: 481 EFCIAVYLME 490
Score = 51.6 bits (122), Expect = 8e-06
Identities = 43/156 (27%), Positives = 69/156 (43%), Gaps = 12/156 (7%)
Query: 9 PLTSEEKQAFSQHFSRLDREQLGIVTGEALRPLFSQSGLTPQQLSQIWTICDTENAGFLT 68
P + + F +F R D + G ++G F S L L+Q+W+ D++ AG+L
Sbjct: 4 PRPTGGQDLFDTYFRRADLDGDGHISGAEAVAFFQGSNLPKHVLAQVWSYADSKKAGYLG 63
Query: 69 VDQFNAALRMVAHLQ---ENPGAQVTLELYQTPASKLPSFGQSQKFNSAST---QPSIPP 122
+F AL++V Q E V +Y ++ +P + K N A+T QP
Sbjct: 64 RAEFYNALKLVTVAQSRRELTAEIVKAAIYSPASANIP----APKINLAATPSPQPRGVL 119
Query: 123 PSNQSHSVQRVPSVIN--RSVSRTNTGSSPTYSVIP 156
P+ Q+ V +PSV R T S+ V+P
Sbjct: 120 PATQAQGVTSMPSVAAGVRGPHMGGTVSTSNQQVVP 155
>CE28509 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 571
Score = 57.8 bits (138), Expect = 1e-07
Identities = 29/71 (40%), Positives = 42/71 (58%), Gaps = 4/71 (5%)
Query: 177 SGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAV 236
+G+L+G A+E +K+KLP LG +W L D G LD EF +A +LI L L+ +
Sbjct: 484 NGYLSGRAAKEHMVKSKLPNSVLGKVWKLADIDKDGQLDADEFALANYLINLKLEGH--- 540
Query: 237 QNLPSTLPNYL 247
+PS LP +L
Sbjct: 541 -EIPSELPKHL 550
>CE25148 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 589
Score = 57.8 bits (138), Expect = 1e-07
Identities = 29/71 (40%), Positives = 42/71 (58%), Gaps = 4/71 (5%)
Query: 177 SGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAV 236
+G+L+G A+E +K+KLP LG +W L D G LD EF +A +LI L L+ +
Sbjct: 502 NGYLSGRAAKEHMVKSKLPNSVLGKVWKLADIDKDGQLDADEFALANYLINLKLEGH--- 558
Query: 237 QNLPSTLPNYL 247
+PS LP +L
Sbjct: 559 -EIPSELPKHL 568
>CE25147 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 835
Score = 57.8 bits (138), Expect = 1e-07
Identities = 29/71 (40%), Positives = 42/71 (58%), Gaps = 4/71 (5%)
Query: 177 SGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAV 236
+G+L+G A+E +K+KLP LG +W L D G LD EF +A +LI L L+ +
Sbjct: 748 NGYLSGRAAKEHMVKSKLPNSVLGKVWKLADIDKDGQLDADEFALANYLINLKLEGH--- 804
Query: 237 QNLPSTLPNYL 247
+PS LP +L
Sbjct: 805 -EIPSELPKHL 814
>CE25146 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 786
Score = 57.8 bits (138), Expect = 1e-07
Identities = 29/71 (40%), Positives = 42/71 (58%), Gaps = 4/71 (5%)
Query: 177 SGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAV 236
+G+L+G A+E +K+KLP LG +W L D G LD EF +A +LI L L+ +
Sbjct: 699 NGYLSGRAAKEHMVKSKLPNSVLGKVWKLADIDKDGQLDADEFALANYLINLKLEGH--- 755
Query: 237 QNLPSTLPNYL 247
+PS LP +L
Sbjct: 756 -EIPSELPKHL 765
>Hs15313972 [Z] KOG0161 Myosin class II heavy chain
Length = 1647
Score = 57.4 bits (137), Expect = 1e-07
Identities = 66/339 (19%), Positives = 131/339 (38%), Gaps = 50/339 (14%)
Query: 572 ELANLSTQVSSLTTQATKVHEEKTAA-----------QNELTRITNMKASI---ETKLIG 617
++A L Q+ L Q K EE A N L + ++A I +
Sbjct: 741 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 800
Query: 618 LRASYNEEVRQTEEIQTQLNALRAQNEELSQQASVAEANYHAVXXXXXXXXXXXXXXXXX 677
+AS N+ +Q ++ +L AL+ + E+ + +
Sbjct: 801 EKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE--------------------LR 840
Query: 678 XXXXXXXXXXFNTLSSQLQQQLAEVQENAKAERSRVDIHAKQLELSEMTANNLQTEIQSL 737
L + + A++Q+ + + ++ ++QLE ++ NL+ Q L
Sbjct: 841 TKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGL 900
Query: 738 EQTLGIYLSKHKELDDYKATIEAQHAEMENKHKQYLATSEEVHARELEVQSRTAEIEKQE 797
E + +KEL ++ AE E+K K+ A +E+HA+ E E+ ++
Sbjct: 901 E-------TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 953
Query: 798 QLYRDQVSRLQELFNDLNKRKSEFEAANAEFEKQQYDYADRVQKFSENQMKLAMGETPDD 857
++++ + L + K+ +F A E Q D + +Q+ + ++ L+ +
Sbjct: 954 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1013
Query: 858 EYTNELIQKRLQIQTAQPAEEEEKPESVFDKDVPTPVSQ 896
E N L +++ EEEE+ +K V SQ
Sbjct: 1014 EEKNSLQEQQ---------EEEEEARKNLEKQVLALQSQ 1043
>Hs13124879 [Z] KOG0161 Myosin class II heavy chain
Length = 1972
Score = 57.4 bits (137), Expect = 1e-07
Identities = 104/552 (18%), Positives = 207/552 (36%), Gaps = 73/552 (13%)
Query: 572 ELANLSTQVSSLTTQATKVHEEKTAA-----------QNELTRITNMKASI---ETKLIG 617
++A+L Q++ L Q K EE AA N L +I ++ I + L
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 618 LRASYNEEVRQTEEIQTQLNALRAQNEELSQQASVAEANYHAVXXXXXXXXXXXXXXXXX 677
RA+ N+ +Q ++ +L AL+ + E+ + +
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE--------------------LR 1169
Query: 678 XXXXXXXXXXFNTLSSQLQQQLAEVQENAKAERSRVDIHAKQLELSEMTANNLQTEIQSL 737
L + + A+VQE + V+ +QLE + NL Q+L
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 738 EQ-------TLGIYLSKHKELDDYKATIEAQHAEMENK----HKQYLATSEEVHARELEV 786
E+ L + +E++ K +EAQ E+++K + +++VH + EV
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 787 QSRTAEIEKQE----QLYRD------QVSRLQELFNDLNKRKSEFEAANAEFEKQQYDYA 836
+S T + + E +L +D Q+ QEL + ++K + E+++
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 837 DRVQKFSENQMKLAMGETPDDEYTNELIQKRLQIQT-AQPAEEEEKPESVFDKDVPTPVS 895
D++ + E + L E +L + ++Q A E E+ + F K++
Sbjct: 1350 DQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 896 QTEPXXXXXXXXXXXXXXXXXXXXXXGNDEVAAEAMADSFEGSLNEYG--IPRTESVTSS 953
Q E D + + E ++ + ++++S
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 954 TANNPPQSVRDEVESEPKENAVLDIDQQLEDAENNDITKQGSETVQPASTDEPLPGGWST 1013
A+ + R E E+ KE L + + LE+A + + + A ++ +
Sbjct: 1467 YAD---ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 1014 GST---LEKDQISDSDADSIKKTPILETQDKVSDAQGA----EIDIPAIQDLKLEDTQVS 1066
G LEK + + KT + E +D++ + A E+++ A++ D Q
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583
Query: 1067 SE--DEKHEQVE 1076
E +EK Q++
Sbjct: 1584 DEQNEEKRRQLQ 1595
>Hs13124875 [Z] KOG0161 Myosin class II heavy chain
Length = 1938
Score = 57.4 bits (137), Expect = 1e-07
Identities = 104/552 (18%), Positives = 207/552 (36%), Gaps = 73/552 (13%)
Query: 572 ELANLSTQVSSLTTQATKVHEEKTAA-----------QNELTRITNMKASI---ETKLIG 617
++A+L Q++ L Q K EE AA N L +I ++ I + L
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 618 LRASYNEEVRQTEEIQTQLNALRAQNEELSQQASVAEANYHAVXXXXXXXXXXXXXXXXX 677
RA+ N+ +Q ++ +L AL+ + E+ + +
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE--------------------LR 1169
Query: 678 XXXXXXXXXXFNTLSSQLQQQLAEVQENAKAERSRVDIHAKQLELSEMTANNLQTEIQSL 737
L + + A+VQE + V+ +QLE + NL Q+L
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 738 EQ-------TLGIYLSKHKELDDYKATIEAQHAEMENK----HKQYLATSEEVHARELEV 786
E+ L + +E++ K +EAQ E+++K + +++VH + EV
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 787 QSRTAEIEKQE----QLYRD------QVSRLQELFNDLNKRKSEFEAANAEFEKQQYDYA 836
+S T + + E +L +D Q+ QEL + ++K + E+++
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 837 DRVQKFSENQMKLAMGETPDDEYTNELIQKRLQIQT-AQPAEEEEKPESVFDKDVPTPVS 895
D++ + E + L E +L + ++Q A E E+ + F K++
Sbjct: 1350 DQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 896 QTEPXXXXXXXXXXXXXXXXXXXXXXGNDEVAAEAMADSFEGSLNEYG--IPRTESVTSS 953
Q E D + + E ++ + ++++S
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 954 TANNPPQSVRDEVESEPKENAVLDIDQQLEDAENNDITKQGSETVQPASTDEPLPGGWST 1013
A+ + R E E+ KE L + + LE+A + + + A ++ +
Sbjct: 1467 YAD---ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 1014 GST---LEKDQISDSDADSIKKTPILETQDKVSDAQGA----EIDIPAIQDLKLEDTQVS 1066
G LEK + + KT + E +D++ + A E+++ A++ D Q
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQAR 1583
Query: 1067 SE--DEKHEQVE 1076
E +EK Q++
Sbjct: 1584 DEQNEEKRRQLQ 1595
>At1g20760 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 1019
Score = 57.4 bits (137), Expect = 1e-07
Identities = 45/155 (29%), Positives = 79/155 (50%), Gaps = 9/155 (5%)
Query: 92 LELYQTPASKLPSFGQSQKFN-SASTQPSIPPPSNQSHSVQRVPSVINRSVSRTNTGSS- 149
L+ Q+ S LPS Q Q+ +AS+QP++ S+Q S P S T G++
Sbjct: 293 LDSLQSTFSMLPSGNQLQQPRPAASSQPAV---SSQGPSSGLPPGSAVGSGHSTPAGNNQ 349
Query: 150 PTYSVIPVCTPHDYAKFAQLF-DRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDR 208
P + P P D K+ ++F + +++ G + G +AR +FL +LP + L +W L D+
Sbjct: 350 PPW---PKMKPSDVQKYTKVFMEVDSDKDGKITGEQARNLFLSWRLPREVLKHVWELSDQ 406
Query: 209 SNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLPSTL 243
N L EF ++++L++ + LPS++
Sbjct: 407 DNDTMLSLREFCISLYLMERYREGRPLPTALPSSI 441
Score = 51.2 bits (121), Expect = 1e-05
Identities = 23/82 (28%), Positives = 46/82 (56%)
Query: 313 QQFDAIFDSLDKEKKGSLGSNVLVPFFLTSKLGQDVLATVWDLADIHNSPVFTKVEFAIA 372
Q++ +F +D +K G + FL+ +L ++VL VW+L+D N + + EF I+
Sbjct: 361 QKYTKVFMEVDSDKDGKITGEQARNLFLSWRLPREVLKHVWELSDQDNDTMLSLREFCIS 420
Query: 373 MFLIQKKNAGIELPDVVPDQLL 394
++L+++ G LP +P ++
Sbjct: 421 LYLMERYREGRPLPTALPSSIM 442
>Hs4758200 [Z] KOG0516 Dystonin GAS (Growth-arrest-specific protein) and related
proteins
Length = 2871
Score = 56.2 bits (134), Expect = 3e-07
Identities = 60/297 (20%), Positives = 119/297 (39%), Gaps = 28/297 (9%)
Query: 567 SQATTELANLSTQVSSLTT---QATKVHEEKTAAQNELTRITN-------MKASIETKLI 616
S AT + L Q LT +V +E+T ++TR N K +E +L
Sbjct: 1519 SSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELN 1578
Query: 617 GLRASYNEEVRQTEEIQTQLNALRAQNEE-------LSQQASVAEANYHAVXXXXXXXXX 669
L+ + +E+ + ++++ +L +R +E L+QQ A
Sbjct: 1579 RLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD 1638
Query: 670 XXXXXXXXXXXXXXXXXXFNTLSSQLQQQLAEVQENAKAERSRVDIHAKQLELSEMTANN 729
++ L++QL + QE+ K R + K +E + N
Sbjct: 1639 VLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698
Query: 730 LQTEIQSLEQTLGIYLSKHKELDDYKATIEAQHAEMENKHKQYLATSEEVHARELEVQSR 789
+ EI+ L+ +H L++ + ++ ++ + + +A LE++S
Sbjct: 1699 SKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE---ADSDKNATILELRS- 1754
Query: 790 TAEIEKQEQLYRDQVSRLQELFNDLNKRKSEFEAANAEFEKQQYDYADRVQKFSENQ 846
Q Q+ ++ LQ L NDL + + +F+KQ + ++R+Q+ S+NQ
Sbjct: 1755 ------QLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE-SKNQ 1804
>YKR092c [Y] KOG2992 Nucleolar GTPase/ATPase p130
Length = 406
Score = 55.5 bits (132), Expect = 5e-07
Identities = 78/376 (20%), Positives = 139/376 (36%), Gaps = 28/376 (7%)
Query: 848 KLAMGETPDDEYTNELIQKRLQIQTAQPAEEEEKPESVFDKDVPTPVSQTEPXXXXXXXX 907
K+ + E P + I+++ ++ + S + S +
Sbjct: 5 KIKVDEVPKLSVKEKEIEEKSSSSSSSSSSSSSSSSSSSSSSSSSGESSSSSSSSSSSSS 64
Query: 908 XXXXXXXXXXXXXXGNDEVAAEAMADSFEGSLNEYGIPRTESVTSSTANNPPQSVRDEVE 967
+ ++ + + E S +E + S +SS++++ S E E
Sbjct: 65 SDSSDSSDSESSSSSSSSSSSSSSSSDSESS-SESDSSSSGSSSSSSSSSDESSSESESE 123
Query: 968 SEPKENAVLDIDQQLEDAENNDITKQGSETVQPASTDEPLPGGWSTGSTLEKDQISDSDA 1027
E K+ A + D E+ TK+ + +S+ E G S+ S E SDSD+
Sbjct: 124 DETKKRA------RESDNEDAKETKKAKTEPESSSSSESSSSGSSSSSESESGSESDSDS 177
Query: 1028 DSIKKTPILETQDKVSDAQGAEIDIPAIQDLKLEDTQVSSEDEKHEQVESSAKNVSSKPD 1087
S + D SD+Q + + D + SS+ SS+ + SS D
Sbjct: 178 SSSSSSSSDSESDSESDSQSSSSS--SSSDSSSDSDSSSSDSSSDSDSSSSSSSSSSDSD 235
Query: 1088 TPEFVNQFEHITHQDLDENVFHDASSVQPFDSEESAKAPVGNDEWDEIFSGLGNNGNTIQ 1147
+ + + D D + D+SS S+ES + + + D SG + T +
Sbjct: 236 S-------DSDSSSDSDSSGSSDSSSSSDSSSDESTSSDSSDSDSDS-DSGSSSELETKE 287
Query: 1148 TS--DVPASVTPTPLQHPVPSAGSLPLSSMSKSPIDRGIAVTPKSLAIEELSSMGFSKEE 1205
+ + A TP PSA S SS +K I G + I+E FS+ +
Sbjct: 288 ATADESKAEETPASSNESTPSASS--SSSANKLNIPAG------TDEIKEGQRKHFSRVD 339
Query: 1206 ATKALEKCDWDLDDAT 1221
+K + W+L D T
Sbjct: 340 RSKINFEA-WELTDNT 354
>Hs18578080 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 534
Score = 54.3 bits (129), Expect = 1e-06
Identities = 30/86 (34%), Positives = 47/86 (53%), Gaps = 4/86 (4%)
Query: 162 DYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVM 221
D + ++F + +G + G A++ +K+KLP LG IW L D G LD EF +
Sbjct: 444 DKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFAL 503
Query: 222 AMHLIQLTLQQNAAVQNLPSTLPNYL 247
A HLI++ L+ + LP+ LP +L
Sbjct: 504 ANHLIKVKLEGH----ELPADLPPHL 525
>7299673 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 493
Score = 53.9 bits (128), Expect = 2e-06
Identities = 52/186 (27%), Positives = 75/186 (39%), Gaps = 24/186 (12%)
Query: 77 RMVAHLQENPGAQVTLELYQTPASKLPSFGQSQKFNSASTQPSIPP-----PSNQSHSVQ 131
R + QE+ G L+Q P + PS G + + Q PP P H
Sbjct: 309 RRLPRHQEDAGGPAAPGLHQVPLPQAPSAGHRGQH---AGQGHCPPDGDDSPGGDDHG-- 363
Query: 132 RVPS------VINRSVS----RTNTGSSPTYSVIPVCTPHDYAKFAQLFDRSTEESGFLA 181
R P+ VI+ VS G Y D + +F+ G ++
Sbjct: 364 RGPNRGAFEGVIDDHVSPFGYMKGEGIDAGYGEHEWICNKDKPRTDGIFNGLGPVDGKIS 423
Query: 182 GNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVMAMHLIQLTLQQNAAVQNLPS 241
G A++ +K+KLP L IW L D G LD EF +A+HLI + L+ LP+
Sbjct: 424 GATAKQELIKSKLPNSVLSKIWKLSDVDGDGFLDSDEFALALHLINVKLEG----CELPT 479
Query: 242 TLPNYL 247
LP +L
Sbjct: 480 VLPEHL 485
>Hs21264315 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 541
Score = 53.5 bits (127), Expect = 2e-06
Identities = 31/86 (36%), Positives = 47/86 (54%), Gaps = 4/86 (4%)
Query: 162 DYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVM 221
D + +LF + +G ++G A++ + +KLP LG IW L D G LD+ EF +
Sbjct: 447 DKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEEEFAL 506
Query: 222 AMHLIQLTLQQNAAVQNLPSTLPNYL 247
A HLI++ L LPS+LP +L
Sbjct: 507 AKHLIKIKLDG----YELPSSLPPHL 528
>7291892 [Z] KOG0161 Myosin class II heavy chain
Length = 2056
Score = 53.5 bits (127), Expect = 2e-06
Identities = 88/476 (18%), Positives = 177/476 (36%), Gaps = 49/476 (10%)
Query: 564 ASLSQATTELANLSTQVSSLTTQATKVHEEKTAAQNELTRITNMKASIETKLIGLRASYN 623
+ L++A L + Q L+++ ++ EK A Q +L K + E KL +
Sbjct: 1398 SQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQ 1457
Query: 624 EEVRQTEE---------------------IQTQLNALRAQNEELSQQASVAEANYHAVXX 662
E ++ EE ++ Q+ L AQN+ L + ++
Sbjct: 1458 EIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATI 1517
Query: 663 XXXXXXXXXXXXXXXXXXXXXXXXXFNTLSSQLQQQLAEVQENAKAERSRVDIHAKQLEL 722
+S Q+ Q+ + A+ + ++V +++L+
Sbjct: 1518 ELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDE 1577
Query: 723 S-------EMTANNLQTEIQSLEQTLGIYLSKHKELDDYKATIEAQHAEMENKHKQY--- 772
+ E LQ E+ L T G EL+ K +E+Q AE++ ++++
Sbjct: 1578 AFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDD 1637
Query: 773 LATSEEVHAR-ELEVQSRTAEIEKQ--------EQLYRDQVSRLQELFNDLNKRKSEFEA 823
L +E+ R E+ +Q+ ++ E+ E+ R V +L++L +L++ + + A
Sbjct: 1638 LQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTA 1697
Query: 824 ANAEFEKQQYDYADRVQKFSENQMKLAMGETPDDEYTNELIQKRLQ--IQTAQPAEEEEK 881
A A +K + D K E M++ D + +Q +++ ++ A+ A+ ++
Sbjct: 1698 AVASKKKLEGDL-----KEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKE 1752
Query: 882 PESVFDKDVPTPVSQTEPXXXXXXXXXXXXXXXXXXXXXXGNDEVAAEAMADSFEGSLNE 941
K+ V E DE+A E ++ +GSL
Sbjct: 1753 ELQALSKEAERKVKALE-AEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMI 1811
Query: 942 YGIPRTES-VTSSTANNPPQSVRDEVESEPKENAVLDIDQQLEDAENNDITKQGSE 996
R E+ + + + EV + A L I+Q + N Q +E
Sbjct: 1812 DEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNE 1867
>Hs7657056 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 535
Score = 53.1 bits (126), Expect = 3e-06
Identities = 29/86 (33%), Positives = 46/86 (52%), Gaps = 4/86 (4%)
Query: 162 DYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVM 221
D + ++F + G + G A++ +++KLP LG IW L D G LD EF +
Sbjct: 444 DKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDDEFAL 503
Query: 222 AMHLIQLTLQQNAAVQNLPSTLPNYL 247
A HLI++ L+ + LP+ LP +L
Sbjct: 504 ANHLIKVKLEGH----ELPNELPAHL 525
>Hs5803009 [TU] KOG1954 Endocytosis/signaling protein EHD1
Length = 534
Score = 52.8 bits (125), Expect = 3e-06
Identities = 29/86 (33%), Positives = 46/86 (52%), Gaps = 4/86 (4%)
Query: 162 DYAKFAQLFDRSTEESGFLAGNKAREIFLKAKLPTQTLGTIWGLCDRSNSGSLDKVEFVM 221
D + ++F + +G + G ++ +K+KLP LG IW L D G LD EF +
Sbjct: 444 DKPSYDEIFYTLSPVNGKITGANVKKEMVKSKLPNTELGKIWKLADVDKDGLLDDEEFAL 503
Query: 222 AMHLIQLTLQQNAAVQNLPSTLPNYL 247
A HLI++ L+ + LP+ LP +L
Sbjct: 504 ANHLIKVKLEGH----ELPADLPPHL 525
>Hs20532997 [Z] KOG0161 Myosin class II heavy chain
Length = 975
Score = 52.0 bits (123), Expect = 6e-06
Identities = 38/163 (23%), Positives = 75/163 (45%), Gaps = 8/163 (4%)
Query: 693 SQLQQQLAEVQENAKAERSRVDIHAKQLELSEMTANNLQTEIQ------SLEQTLGIYLS 746
S+L + VQE +++ D+H ++ +LS ++ NL+ E Q +LEQ ++
Sbjct: 31 SKLNRAAKVVQE--AHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMN 88
Query: 747 KHKELDDYKATIEAQHAEMENKHKQYLATSEEVHARELEVQSRTAEIEKQEQLYRDQVSR 806
+EL + ++ MEN +EE+ +ELE+ +++E ++ L
Sbjct: 89 CERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKT 148
Query: 807 LQELFNDLNKRKSEFEAANAEFEKQQYDYADRVQKFSENQMKL 849
++EL + K + EA K + + AD Q ++ +L
Sbjct: 149 VKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERL 191
>CE09349 [Z] KOG0161 Myosin class II heavy chain
Length = 1963
Score = 52.0 bits (123), Expect = 6e-06
Identities = 72/324 (22%), Positives = 129/324 (39%), Gaps = 34/324 (10%)
Query: 583 LTTQATKVHEEKTAAQNELTRITNMKASIETKLIGLRASYNEEVRQTEEIQTQLNALRAQ 642
L + K+ EEKT+ L + E +L L A + +Q E+ QL A
Sbjct: 882 LEESSAKLVEEKTSLFTNLESTKTQLSDAEERLAKLEAQQKDASKQLSELNDQL----AD 937
Query: 643 NEELSQQASVAEANYHA-VXXXXXXXXXXXXXXXXXXXXXXXXXXXFNTLSSQLQQQLAE 701
NE+ + A+ A V +L ++QQQ
Sbjct: 938 NEDRTADVQRAKKKIEAEVEALKKQIQDLEMSLRKAESEKQSKDHQIRSLQDEMQQQDEA 997
Query: 702 VQENAKAERSRVDIHAKQLE--LSEMTANNLQTEIQS-LEQTLGIY---LSKHK----EL 751
+ + K ++ + +I+ K +E SE N Q ++++ LEQTL L + K +L
Sbjct: 998 IAKLNKEKKHQEEINRKLMEDLQSEEDKGNHQNKVKAKLEQTLDDLEDSLEREKRARADL 1057
Query: 752 DDYKATIEA--------------QHAEMENKHKQYLATSEEVHARELEVQSRTAEIEKQE 797
D K +E Q ++EN K+ E+H+ ++ A + K +
Sbjct: 1058 DKQKRKVEGELKIAQENIDESGRQRHDLENNLKK---KESELHSVSSRLEDEQALVSKLQ 1114
Query: 798 QLYRDQVSRLQELFNDL-NKRKSEFEAANAEFEKQQYDYADRVQKFSENQMKLAMGETPD 856
+ +D SR+ EL +L N+R+S +A A+ + Q+ + + +K E A +
Sbjct: 1115 RQIKDGQSRISELEEELENERQSRSKADRAKSDLQR-ELEELGEKLDEQGGATAAQVEVN 1173
Query: 857 DEYTNELIQKRLQIQTAQPAEEEE 880
+ EL + R ++ A E +
Sbjct: 1174 KKREAELAKLRRDLEEANMNHENQ 1197
>Hs12667788 [Z] KOG0161 Myosin class II heavy chain
Length = 1960
Score = 51.6 bits (122), Expect = 8e-06
Identities = 68/355 (19%), Positives = 132/355 (37%), Gaps = 45/355 (12%)
Query: 572 ELANLSTQVSSLTTQATKVHEEKTAAQNELTRITNMKASIETKLIGLRASYNEEVRQTEE 631
++A L Q++ L Q K EE AA L R+ A L +R E Q E
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAA---LARVEEEAAQKNMALKKIR----ELESQISE 1115
Query: 632 IQTQLNALRAQNEELSQQASVAEANYHAVXXXXXXXXXXXXXXXXXXXXXXXXXXXFN-T 690
+Q L + RA + +Q A+ T
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT 1175
Query: 691 LSSQLQQQLAEVQENAKAERSRVDIHAKQLELSEMTANNLQTEIQSLEQTLG-------I 743
L + + A++QE + V+ A+QLE ++ NL+ Q+LE G +
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV 1235
Query: 744 YLSKHKELDDYKATIEAQHAEMENKHKQYLATSEEVHARELEVQ--------------SR 789
L + + + +EAQ E++ K + E+ + ++Q S+
Sbjct: 1236 LLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSK 1295
Query: 790 TAEIEKQEQLYRDQVSRLQELFNDLNKRKSEFEAANAEFEKQQYDYADRVQKFSENQ--- 846
++++ K Q+ QEL + N++K + E ++ + +++++ E +
Sbjct: 1296 SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355
Query: 847 -------------MKLAMGETPDDEYTNELIQKRLQIQTAQPAEEEEKPESVFDK 888
MK M ++ T E ++++LQ ++ E+ + +DK
Sbjct: 1356 EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK 1410
Score = 51.2 bits (121), Expect = 1e-05
Identities = 72/347 (20%), Positives = 130/347 (36%), Gaps = 34/347 (9%)
Query: 546 VSVPSREVTSNNREIVPPASLSQATTELANLSTQVSSLTTQATKVHEEKTAAQNELTRIT 605
V V +++ + NR SQ E L Q+ + T + E + R+T
Sbjct: 855 VKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRA-------RLT 907
Query: 606 NMKASIETKLIGLRASYNEEVRQTEEIQTQLNALRAQNEELSQQASVAEANYHAVXXXXX 665
K +E L A EE + + +Q + ++ +EL +Q E+ +
Sbjct: 908 AKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV 967
Query: 666 XXXXXXXXXXXXXXXXXXXXXXFNTLSSQLQQQLAEVQENAKAERSRVDIHAKQLELSEM 725
L+ ++AE N E + AK E
Sbjct: 968 TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027
Query: 726 TANNLQTEI-------QSLEQTLGIYLSKHKELDDYKATIEAQHAEMENKHKQYLATSEE 778
+L+ + Q LE+T +L D A ++AQ AE+ K LA EE
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL----KMQLAKKEE 1083
Query: 779 VHARELEVQSRTAEIEKQEQLYRDQVSRLQELFNDLNKRKSEFEAANA---EFEKQQYDY 835
E+Q+ A +E++ + +++EL + +++ + + E+ A + EKQ+ D
Sbjct: 1084 ------ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL 1137
Query: 836 ADRVQKFSENQMKLAMGETPDDEYT-NELIQKRLQ-IQTAQPAEEEE 880
+ ++ +K + +T D EL KR Q + + EEE
Sbjct: 1138 GEELE-----ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
>CE04618 [Z] KOG0161 Myosin class II heavy chain
Length = 1956
Score = 51.6 bits (122), Expect = 8e-06
Identities = 57/297 (19%), Positives = 115/297 (38%), Gaps = 30/297 (10%)
Query: 552 EVTSNNREIVPPASLSQATTELANLSTQVSSLTTQATKVHEEKTAAQNELTRITNMKASI 611
E+ + R+++ A L + LA +V L Q K EE Q++LTR A++
Sbjct: 1044 ELEQHKRKLL--AELEDSKDHLAEKMGKVEELNNQLMKRDEE---LQHQLTRYDEESANV 1098
Query: 612 ETKLIGLRASYNEEVRQTEEIQTQLNALR----AQNEELSQQASVAEANYHAVXXXXXXX 667
+R E+++T+ NA + E ++Q V V
Sbjct: 1099 TLMQKQMRDMQTTIDELREDMETERNARNKAEMTRREVVAQLEKVKGDVLDKVDEATMLQ 1158
Query: 668 XXXXXXXXXXXXXXXXXXXXFNTLSSQLQQQLAEVQENAKAERSRVDIHAKQLELSEMTA 727
+T+ ++++Q A+ + +++ H KQ E
Sbjct: 1159 DLMSRKDEEVNATKRAIEQIQHTMEGKIEEQKAKFSRQVEELHDQIEQHKKQRSQLEKQQ 1218
Query: 728 NNLQTEIQSLEQTLGIYLSKHKELDDYKATIEAQHAEMENKHKQYLATSEEVHARELEVQ 787
N E + Q + A ++A A+++ K K + A +E+Q
Sbjct: 1219 NQADQERADMAQEI--------------ALLQASRADIDKKRKIH-------EAHLMEIQ 1257
Query: 788 SRTAEIEKQEQLYRDQVSRLQELFNDLNKRKSEFEAANAEFEKQQYDYADRVQKFSE 844
+ AE ++ ++ DQ+ R ++ + LN+ + E E A A +++ ++Q+ +E
Sbjct: 1258 ANLAESDEHKRTLIDQLERSRDELDHLNRVREEEEHAFANMQRRLATAEGQIQELNE 1314
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.309 0.125 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,933,560
Number of Sequences: 60738
Number of extensions: 2808223
Number of successful extensions: 14858
Number of sequences better than 1.0e-05: 37
Number of HSP's better than 0.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 14434
Number of HSP's gapped (non-prelim): 275
length of query: 1228
length of database: 30,389,216
effective HSP length: 118
effective length of query: 1110
effective length of database: 23,222,132
effective search space: 25776566520
effective search space used: 25776566520
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)