ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1484 good R KOG1089 General function prediction only Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1484 522591 520705 -629
(629 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJR110w [R] KOG1089 Myotubularin-related phosphatidylinositol 3-... 640 0.0
SPAC19A8.03 [R] KOG1089 Myotubularin-related phosphatidylinosito... 464 e-130
Hs21361759_1 [R] KOG1089 Myotubularin-related phosphatidylinosit... 312 1e-84
Hs20548550 [R] KOG1089 Myotubularin-related phosphatidylinositol... 302 9e-82
7291573 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-... 299 7e-81
Hs7705564 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosph... 298 2e-80
Hs22055421 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosp... 292 9e-79
CE16100 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-... 285 1e-76
Hs4557896 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosph... 283 7e-76
7297058 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphat... 262 1e-69
CE24125 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphat... 248 2e-65
Hs10863893 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosp... 241 3e-63
Hs19923424 [R] KOG1089 Myotubularin-related phosphatidylinositol... 239 7e-63
Hs10835109 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosp... 237 3e-62
At3g10550 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosph... 215 2e-55
7293198 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphat... 199 1e-50
Hs14751578 [R] KOG1089 Myotubularin-related phosphatidylinositol... 196 9e-50
At5g04540 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosph... 194 4e-49
CE28087 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-... 193 8e-49
CE03708 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-... 193 8e-49
HsM8923126_1 [R] KOG1089 Myotubularin-related phosphatidylinosit... 179 1e-44
CE26073 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-... 176 1e-43
7295015 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-... 162 1e-39
Hs22069399 [R] KOG1090 Predicted dual-specificity phosphatase 136 1e-31
7299513 [R] KOG1090 Predicted dual-specificity phosphatase 127 4e-29
Hs8923297 [R] KOG1089 Myotubularin-related phosphatidylinositol ... 108 2e-23
7293003 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-... 88 3e-17
Hs9506679 [R] KOG1089 Myotubularin-related phosphatidylinositol ... 75 4e-13
CE23833 [R] KOG1090 Predicted dual-specificity phosphatase 70 1e-11
>YJR110w [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 688
Score = 640 bits (1651), Expect = 0.0
Identities = 335/689 (48%), Positives = 446/689 (64%), Gaps = 61/689 (8%)
Query: 1 MDYIKIARVDNVIWHKRGISLKGSLHLTTHHLIFTDDNSSREFWVAYPTIASVFKNKGSS 60
M+YIKIA+V NV+ H+RG + +G+LHLTTHHLIF S EFW YP I V KN GS+
Sbjct: 1 MEYIKIAKVSNVVLHRRGTATQGTLHLTTHHLIFESPQLSTEFWFPYPLIYGVHKNPGST 60
Query: 61 LISKYKHHSEWEKEA-------LYAGKDIWMFFNIKVITKDYNIFSLDLENEKNTQ--DV 111
L+SK ++ + E LY GKD+W F NIKVI KDY +FSLD + + Q V
Sbjct: 61 LLSKLTSTNQIQLEGTDSQNYKLYQGKDLWSFVNIKVIGKDYAVFSLDFGGDLHLQARKV 120
Query: 112 YDSLCKLTILDDVHKLYAFIYSPNKAETPF---NSWNIYDPVKEFERQGLNFGDEECCKW 168
YDS+ LT+L ++ +LYAFIY N E +SW+IYDP+KEF RQGL+ DE C W
Sbjct: 121 YDSILNLTVLSNITQLYAFIYISNNLERKLPSPDSWDIYDPIKEFRRQGLDSKDETC-PW 179
Query: 169 RVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRCA 228
R+S +NE Y FC TYPSKL VP++ SD L+ ++ K+RSQ+RIP LTY++ +I R +
Sbjct: 180 RLSTVNEHYEFCPTYPSKLFVPRSTSDILLKHASKFRSQKRIPVLTYHHKATDCNILRSS 239
Query: 229 QPLPGITQQRSIQDEKLIREIFNCSINKT---SKNIIVDARPTTNAMAQTALGGGTENMD 285
QPLPG+ QRSIQDEKL+ E FN NK +K++IVDARP TNA+AQ ALGGGTENMD
Sbjct: 240 QPLPGLINQRSIQDEKLVWESFNSFCNKDIRRTKHVIVDARPRTNALAQMALGGGTENMD 299
Query: 286 NYGFN--------------QTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSM 331
NY F T +R+FLGIDNIH++ ++ Y+ + DL LP+++++
Sbjct: 300 NYNFFLADNNMGVDKSLKLPTVTRLFLGIDNIHIVSNTAAYMTEVICQGGDLNLPLEQNL 359
Query: 332 LNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYY 391
+ S K S+WLK L+L S D L+KSI+FN+SN+LVHCSDGWDRT+Q+ SL+++ LDP+Y
Sbjct: 360 IRSQKFSNWLKLNTLILKSVDMLLKSIIFNHSNVLVHCSDGWDRTSQVVSLLEICLDPFY 419
Query: 392 RTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNS---------TRXXXXXXXXXXX 442
RT EGFM+LVEKDW +FGHRF ERSGHL+S FHDN+ T
Sbjct: 420 RTFEGFMILVEKDWCSFGHRFLERSGHLNSDIRFHDNTMHSNFNDVDTNGDDLDIGVNTQ 479
Query: 443 XNDKKENELGEFSTMTSPETRISSTF-KKFR-NGTNMKLTSPVFQQFLDCVHQLLIQYPT 500
+ +++E GE T +RIS F + F+ N ++K SPVFQQFLDCV+QLL Q P
Sbjct: 480 DDYAEDDEGGEDETNLINLSRISKKFNENFKLNKKSLKFVSPVFQQFLDCVYQLLTQNPD 539
Query: 501 QFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSVWDYFRSRTHEFSNPNY 560
FEFNERFLRRLVYHLYSCQYGTF+ ++E E+ N ++T+SVWDYFRSR +F NPN+
Sbjct: 540 LFEFNERFLRRLVYHLYSCQYGTFLSNSEKEKFQQNLPNKTKSVWDYFRSRRKQFINPNF 599
Query: 561 RE-------------PSDDEEDWILPDWEKVEWWWQLFGRRDAEMN-------GPCPTHE 600
+ +++ +WI PD +KV+WWWQL+GR+D+EMN P
Sbjct: 600 IQRKRSGMNEHDQNLEEEEKVEWISPDLKKVQWWWQLYGRKDSEMNDELRHKRDSVPISV 659
Query: 601 DEDTLVKKTNTIVSSLKMPKFSLEIFSKK 629
D+ + + L + F ++F++K
Sbjct: 660 DKKSKEHSNSDGGKGLNLSIFGFDMFNRK 688
>SPAC19A8.03 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 559
Score = 464 bits (1195), Expect = e-130
Identities = 263/603 (43%), Positives = 358/603 (58%), Gaps = 54/603 (8%)
Query: 1 MDYIKIARVDNVIWHKRGISLKGSLHLTTHHLIFTDDNSSREFWVAYPTIASVFKNKGSS 60
M+ IK+A+V NV + +G L G+LHLT +H IF+ + +E W AY I +V
Sbjct: 1 MENIKVAKVGNVKFVNKGNELNGTLHLTAYHSIFSISENGKEIWTAYSMINNV------K 54
Query: 61 LISKYKHHSEWEKEALYAGKDIWMFFNIKVITKDYNIFSLDLENEKNTQDVYDSLCKLTI 120
L S K F I++ +D+ F ++ ++ DVYD+L +L
Sbjct: 55 LCSNEKS------------------FCIRIQCRDFMFFCWRFQSTEDAMDVYDTLQELMS 96
Query: 121 LDDVHKLYAFIYSPNKAETPF-NSWNIYDPVKEFERQGLNFG---DEECCKWRVSDINED 176
++ ++ LYAF Y P+ E +SW + E+ R G+ D WR++ INE+
Sbjct: 97 INSINMLYAFYYMPSGDEEKLPSSWKSFLLENEYRRMGVGDSTQADGAGGNWRITKINEN 156
Query: 177 YSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRCAQPLPGITQ 236
YS C +YP L VP ++SD++I Y KYRS+ R P LTY + KN SITR +QPL GI Q
Sbjct: 157 YSECHSYPQALAVPASISDSVIYYGCKYRSKNRFPTLTYLH-KNSFSITRASQPLVGIRQ 215
Query: 237 QRSIQDEKLIREIFNCSINKTSKNIIVDARPTTNAMAQTALGGGTENMDNYGFNQTCSRM 296
RS QDEKL+ IF SI +N+IVDARP+TNAMA A+G G+ENMD+Y F ++
Sbjct: 216 NRSAQDEKLVEAIFATSIIPGKENLIVDARPSTNAMANIAVGAGSENMDHYRF---AKKI 272
Query: 297 FLGIDNIHVMRDSLNYLVDNFLVDNDLYL-PIDKSMLNSDKSSSWLKYIKLLLSSTDTLV 355
+LGIDNIHVMRDSLN +V N L + D+ P +LN SSWLK++ +L +V
Sbjct: 273 YLGIDNIHVMRDSLNKIV-NALKNTDISAAPPLIELLNR---SSWLKHLANILQGAVLIV 328
Query: 356 KSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCER 415
K++ F ++++LVHCSDGWDRT+Q+ +L QL LDPYYRTIEGF LVEKDWL+FGHRF ER
Sbjct: 329 KTVHFRHAHVLVHCSDGWDRTSQLCALPQLCLDPYYRTIEGFFALVEKDWLSFGHRFAER 388
Query: 416 SGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISSTFKKFRNGT 475
HL +F +S+ ++ + ST+ + + S F
Sbjct: 389 CCHLPGKRIFTIDSSYS-------------EEPPQSSPSSTLQYTFSTVRSALSGFSIDH 435
Query: 476 NMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTN 535
+ K+ SPVF QFLDCV Q++ Q+P FEFNERFLRRL+YHLYSCQYG+F++++E ER
Sbjct: 436 SEKMMSPVFHQFLDCVWQIMDQFPNCFEFNERFLRRLLYHLYSCQYGSFLYNSERERAQA 495
Query: 536 NAFHQTRSVWDYFRSRTHEFSNPNYREPSDDEEDWILPDWEKVEWWWQLFGRRDAEMNGP 595
+ TR +WDYF SR EF NPNY P DD I+PD + WW F + D MN P
Sbjct: 496 SVSTHTRCIWDYFLSRKDEFKNPNY-VPYDDV---IMPDPSSLRWWSASFAQPDENMNIP 551
Query: 596 CPT 598
P+
Sbjct: 552 SPS 554
>Hs21361759_1 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 505
Score = 312 bits (799), Expect = 1e-84
Identities = 193/568 (33%), Positives = 293/568 (50%), Gaps = 99/568 (17%)
Query: 1 MDYIKIARVDNVIWHKRGISLK---GSLHLTTHHLIFTDDNSS--REFWVAYPTIASVFK 55
MD+I + +V+NV R +S K G L+LT HLI+ + + + +E W+A IA+V K
Sbjct: 1 MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEK 60
Query: 56 NKGSSLISKYKHHSEWEKEALYAGKDIWMFFNIKVITKDYNIFSLDLENEKNTQDVYDSL 115
+SL + + K++ + L+++ +VY SL
Sbjct: 61 LPITSLGCP-----------------------LTLRCKNFRVAHFVLDSDLVCHEVYISL 97
Query: 116 CKLTILDDVHKLYAFIYSPNKA-ETPFNSWNIYDPVKEFERQGLNFGDEECCKWRVSDIN 174
KL+ LYAF Y+P + E + W + DP+ +F R G+ + W ++D N
Sbjct: 98 LKLSQPALPEDLYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRN-----WTITDAN 152
Query: 175 EDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRCAQPLPGI 234
+Y C TYP ++VVPK+V+ + S K+RS++R+P L+Y Y +N A+I RC+QPL G
Sbjct: 153 RNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGF 212
Query: 235 TQQRSIQDEKLIREIFNCSINKTSKNI-IVDARPTTNAMAQTALGGGTENMDNYGFNQTC 293
R + DE L+ I N S+ + +VD RP NAMA A G G EN DNY
Sbjct: 213 -YTRCVDDELLLEAI--SQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYA---NI 266
Query: 294 SRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDT 353
F+GI+NIHVMR SL L++ +L P L+ +SS WL++IK ++ +
Sbjct: 267 RFRFMGIENIHVMRSSLQKLLEVC----ELKTPTMSEFLSGLESSGWLRHIKAIMDAGIF 322
Query: 354 LVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFC 413
+ K++ +++LVHCSDGWDRTAQ+ S+ + LDP+YRT +G M+L+EK+W++ GH+F
Sbjct: 323 ITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFS 382
Query: 414 ERSGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISSTFKKFRN 473
+R GHL D KE
Sbjct: 383 QRCGHLD-----------------------GDSKE------------------------- 394
Query: 474 GTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERV 533
SP+F QFLDC+ QL+ Q+P FEFNE FL + H++SCQ+G F+ + + +R
Sbjct: 395 ------VSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDRE 448
Query: 534 TNNAFHQTRSVWDYFRSRTHEFSNPNYR 561
+ +T SVW + R +F NP Y+
Sbjct: 449 DLRVYEKTHSVWPFLVQRKPDFRNPLYK 476
>Hs20548550 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 621
Score = 302 bits (774), Expect = 9e-82
Identities = 197/574 (34%), Positives = 288/574 (49%), Gaps = 107/574 (18%)
Query: 1 MDYIKIARVDNVIWHKR----GISLKGSLHLTTHHLIFTDDNSSREFWVAYPTIASVFKN 56
M++I+ +V+ V R SL G+L+LT HL+F D + +E W+ + IASV
Sbjct: 1 MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQ-KETWILHHHIASV--- 56
Query: 57 KGSSLISKYKHHSEWEKEALYAGKDIWMFFNIKVITKDYNIFSLDLENEKNTQDVYDSLC 116
EK AL + + K++ + E++ D+Y+SL
Sbjct: 57 ---------------EKLALTTSG-----CPLVIQCKNFRTVHFIVPRERDCHDIYNSLL 96
Query: 117 KLTILDDVHKLYAFIYSPNKAETP-FNSWNIYDPVKEFERQGLNFGDEECCKWRVSDINE 175
+L+ LYAF Y+P + ++ W + D +E++R G+ W++SD N
Sbjct: 97 QLSKQAKYEDLYAFSYNPKQNDSERLQGWQLIDLAEEYKRMGVPNSH-----WQLSDANR 151
Query: 176 DYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRCAQPLPGIT 235
DY C TYP +L VP+ S +I S K+RS+ R P L+YY+ A+I RC+QPL G +
Sbjct: 152 DYKICETYPRELYVPRIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFS 211
Query: 236 QQRSIQDEKLIREIFNCS-INKTSKNIIVDARPTTNAMAQTALGGGTENMDNYGFNQTCS 294
R ++DE L++ I + +N+ ++D RP NAMA A G G EN DNY
Sbjct: 212 A-RCLEDEHLLQAISKANPVNRYM--YVMDTRPKLNAMANRAAGKGYENEDNYS---NIR 265
Query: 295 RMFLGIDNIHVMRDSLNYLVD----NFLVDNDLYLPIDKSMLNSDKSSSWLKYIKLLLSS 350
F+GI+NIHVMR SL L++ L ND Y ++ SS WL++IK ++ +
Sbjct: 266 FQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLE--------SSGWLRHIKAVMDA 317
Query: 351 TDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGH 410
L K+I N+++LVHCSDGWDRT+Q+ SL L LD YYRTI+GFMVL+EKDW++FGH
Sbjct: 318 AIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGH 377
Query: 411 RFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISSTFKK 470
+F ER G L D KE
Sbjct: 378 KFSERCGQLD-----------------------GDPKE---------------------- 392
Query: 471 FRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEY 530
SPVF QFL+CV L Q+P FEF+E FL ++ H++SCQ+G F+ + +
Sbjct: 393 ---------VSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQK 443
Query: 531 ERVTNNAFHQTRSVWDYFRSRTHEFSNPNYREPS 564
ER +T S+W + ++ NP Y S
Sbjct: 444 EREELKLKEKTYSLWPFLLEDQKKYLNPLYSSES 477
>7291573 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 676
Score = 299 bits (766), Expect = 7e-81
Identities = 193/550 (35%), Positives = 283/550 (51%), Gaps = 103/550 (18%)
Query: 23 GSLHLTTHHLIFTDDNSSREFWVAYPTIASVFK----NKGSSLISKYKHHSEWEKEALYA 78
G+L+LT HLIF + +S++E W+ + +AS+ K GS L+ + K
Sbjct: 13 GTLYLTATHLIFVEPDSNKETWILHMHVASIEKLPLSTTGSPLLIRCK------------ 60
Query: 79 GKDIWMFFNIKVITKDYNIFSLDLENEKNTQDVYDSLCKLTILDDVHKLYAFIYSPNKAE 138
F ++ + + + DVY SL KL ++KLY F Y PNK +
Sbjct: 61 -----TFLSVTFV----------IPKDSECHDVYTSLLKLFQPVSINKLYCFNYQPNKDD 105
Query: 139 TPFNS-WNIYDPVKEFERQGLNFGDEECCKWRVSDINEDYSFCRTYPSKLVVPKTVSDTL 197
P N+ W+ + EF+ + +E W + +NE Y C TYP ++ VPK + +
Sbjct: 106 FPKNAGWDYFKLEAEFKH--MLVPNE---AWTLCSMNEKYELCDTYPRQIYVPKEATTLM 160
Query: 198 ISYSVKYRSQQRIPALTYYYAKNGASITRCAQPLPGITQQRSIQDEKLIREIFNCSINKT 257
+ S ++RS+ R+P LTY + N ASI RC+QPL G + R ++DE+++ I + N T
Sbjct: 161 LISSSRFRSKGRLPVLTYLH-NNKASICRCSQPLSGFS-ARCLEDEQMLEAIRKTNSN-T 217
Query: 258 SKNIIVDARPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDNF 317
+VD RP NAMA A G G E N F + FLGI+NIHV R SL +++
Sbjct: 218 DYMYVVDTRPRINAMANRAAGKGYE---NEAFYENIKFHFLGIENIHVQRASLQKVLEAC 274
Query: 318 LVDNDLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTA 377
+ P + +N+ +SS WLK+I+ +L T + + + V +++VHCSDGWDRTA
Sbjct: 275 ----EQKSPTMSAFINALESSGWLKHIRSIL-DTSSFIANAVDKGVSVVVHCSDGWDRTA 329
Query: 378 QITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXX 437
Q+ SL QL L+PYYRTI+GF L+EKDWLAFGH+F ER GH+ +
Sbjct: 330 QVCSLAQLMLNPYYRTIKGFQALIEKDWLAFGHKFSERCGHIQT---------------- 373
Query: 438 XXXXXXNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQ 497
D +E SP+F QFLDC QL+ Q
Sbjct: 374 -------DARE-------------------------------VSPIFTQFLDCTWQLMSQ 395
Query: 498 YPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSVWDYFRSRTHEFSN 557
FEFNERFL L H++SCQ+GTF+ + E +R+ +T S+W Y + +E+ N
Sbjct: 396 RSEAFEFNERFLLILHDHVHSCQFGTFVGNCEKDRLDLKLAERTFSLWGYMANHLNEYIN 455
Query: 558 PNYREPSDDE 567
P Y+ P+ DE
Sbjct: 456 PLYK-PNVDE 464
>Hs7705564 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 643
Score = 298 bits (762), Expect = 2e-80
Identities = 185/526 (35%), Positives = 277/526 (52%), Gaps = 74/526 (14%)
Query: 86 FNIKVITKDYNIFSLDLENEKNTQ-DVYDSLCKLTI-LDDVHKLYAFIYSPNKAETPFNS 143
+ ++ + KD + E T+ ++++L K + + L+AF Y K P N
Sbjct: 149 YGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEY---KEVFPENG 205
Query: 144 WNIYDPVKEFERQGLNFGDEECCKWRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVK 203
W +YDP+ E+ RQG+ WR++ INE Y C TYP+ LVVP + D +
Sbjct: 206 WKLYDPLLEYRRQGIPNES-----WRITKINERYELCDTYPALLVVPANIPDEELKRVAS 260
Query: 204 YRSQQRIPALTYYYAKNGASITRCAQPLPGITQQRSIQDEKLIREIFNCSINKTSKNIIV 263
+RS+ RIP L++ + ++ A+ITRC+QP+ G++ +RS +DEK ++ I + + ++ K I
Sbjct: 261 FRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNA-QSHKIFIF 319
Query: 264 DARPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDL 323
DARP+ NA+A A GGG E+ D Y Q +FL I NIHVMR+SL L + +
Sbjct: 320 DARPSVNAVANKAKGGGYESEDAY---QNAELVFLDIHNIHVMRESLRKLKEI------V 370
Query: 324 YLPIDKS-MLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSL 382
Y I+++ L++ +S+ WL++IKL+L+ + + ++++VHCSDGWDRTAQ+TSL
Sbjct: 371 YPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSL 430
Query: 383 VQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXX 442
L LD YYRTI GF VLVEK+WL+FGHRF R GH + D S
Sbjct: 431 AMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRS------------- 477
Query: 443 XNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQF 502
PVF QF+DCV Q+ Q+PT F
Sbjct: 478 ---------------------------------------PVFLQFIDCVWQMTRQFPTAF 498
Query: 503 EFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSVWDYFRSRTHEFSNPNYRE 562
EFNE FL ++ HLYSC +GTF+ ++E +R N +T S+W Y S+ +F+NP Y
Sbjct: 499 EFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGS 558
Query: 563 PSDDEEDWILPDWEKVEWWWQLFGRRDAEMNGPCPTHEDEDTLVKK 608
S + + + +E W + R + M P H L+ K
Sbjct: 559 YS-NHVLYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAK 603
>Hs22055421 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 571
Score = 292 bits (748), Expect = 9e-79
Identities = 179/520 (34%), Positives = 274/520 (52%), Gaps = 80/520 (15%)
Query: 88 IKVITKDYNIFSLDLENEKNTQ-DVYDSLCKLTI-LDDVHKLYAFIYSPNKAETPFNSWN 145
I+++ KD L + E+ ++ ++++L K L + L+AF Y K + P N W
Sbjct: 78 IEIVCKDMRNLRLAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSY---KEKFPINGWK 134
Query: 146 IYDPVKEFERQGLNFGDEECCKWRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYR 205
+YDPV E++RQGL W++S IN +Y FC TYP+ +VVP +V D +S +R
Sbjct: 135 VYDPVSEYKRQGLPNES-----WKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFR 189
Query: 206 SQQRIPALTYYYAKNGASITRCAQPLPGITQQRSIQDEKLIREIFNCSINKTSKNIIVDA 265
++ R+P L++ + ++ A+ITRC+QPL G +R +DEK ++ I + + ++ K II DA
Sbjct: 190 AKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANA-QSHKLIIFDA 248
Query: 266 RPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYL 325
R + A GGG E+ Y +FL I NIHVMR+SL L + +Y
Sbjct: 249 RQNSVADTNKTKGGGYESESAY---PNAELVFLEIHNIHVMRESLRKLKEI------VYP 299
Query: 326 PIDKSM-LNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQ 384
ID++ L++ + WL+YI++LL+ + I ++++VHCSDGWDRTAQ+TSL
Sbjct: 300 SIDEARWLSNVDGTHWLEYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAM 359
Query: 385 LSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXN 444
L LD YYRTI+GF LVEK+W++FGHRF R GH + + D S
Sbjct: 360 LMLDSYYRTIKGFETLVEKEWISFGHRFALRVGHGNDNHADADRS--------------- 404
Query: 445 DKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEF 504
P+F QF+DCV Q+ Q+P+ FEF
Sbjct: 405 -------------------------------------PIFLQFVDCVWQMTRQFPSAFEF 427
Query: 505 NERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSVWDYFRSRTHEFSNP---NYR 561
NE FL ++ HLYSC +GTF+ + E +R + + +T S+W Y S+ EFSNP NY
Sbjct: 428 NELFLITILDHLYSCLFGTFLCNCEQQRFKEDVYTKTISLWSYINSQLDEFSNPFFVNY- 486
Query: 562 EPSDDEEDWILPDWEKVEWWWQLFGRRDAEMNGPCPTHED 601
++ + + +E W + R + M P H++
Sbjct: 487 ---ENHVLYPVASLSHLELWVNYYVRWNPRMRPQMPIHQN 523
>CE16100 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 676
Score = 285 bits (729), Expect = 1e-76
Identities = 183/564 (32%), Positives = 280/564 (49%), Gaps = 100/564 (17%)
Query: 4 IKIARVDNVIWHKR---GISLKGSLHLTTHHLIFTDDNSSREFWVAYPTIASVFKNK--- 57
I I++VD V R +L G++H+TT H+IF +N S+E W+A I+SV K
Sbjct: 6 IGISKVDKVCLVDRLGCQENLVGTVHVTTTHIIFRAENGSKELWLATGLISSVEKGTLTA 65
Query: 58 -GSSLISKYKHHSEWEKEALYAGKDIWMFFNIKVITKDYNIFSLDLENEKNTQDVYDSLC 116
G L+ + KH + + +L + +K+ QD+Y++L
Sbjct: 66 AGCMLVIRCKH---------------------------FQVITLLISRDKSCQDLYETLQ 98
Query: 117 KLTILDDVHKLYAFIYSPNKAETPFNSWNIYDPVKEFERQGLNFGDEECCKWRVSDINED 176
+ V+ + + W D E RQG+ +W S+INE
Sbjct: 99 RAAKPVSVNVTELLAFENREPVEDVRGWRRLDWNSEMTRQGITKS-----QWTESNINEG 153
Query: 177 YSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRCAQPLPGITQ 236
Y+ C TYP+KL P S +++ S K+RS+ R+P LTY++ + A++ RCAQPL G +
Sbjct: 154 YTICDTYPNKLWFPTAASTSVLLGSCKFRSRGRLPVLTYFHQQTEAALCRCAQPLTGFSA 213
Query: 237 QRSIQDEKLIREIFNCSINKTSKNIIVDARPTTNAMAQTALGGGTENMDNYGFNQTCSRM 296
R ++DEKL+ + + N + +VD RP NAM G G E+ NY
Sbjct: 214 -RCVEDEKLMELVGKANTNSDNL-FLVDTRPRVNAMVNKVQGKGFEDERNYS---NMRFH 268
Query: 297 FLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVK 356
F I+NIHVMR S L+D D+ + ++S WLK+++ ++ + L +
Sbjct: 269 FFDIENIHVMRASQARLLDAVTKCRDV-----TEYWKTLEASGWLKHVRSVVECSLFLAE 323
Query: 357 SIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERS 416
SI ++ +VHCSDGWDRT+Q+ +L QL LDPYYRTI GF VL+EKDWL FGH+F +R
Sbjct: 324 SIS-RGTSCVVHCSDGWDRTSQVVALCQLLLDPYYRTIHGFQVLIEKDWLGFGHKFDDRC 382
Query: 417 GHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISSTFKKFRNGTN 476
GH+ + ND+ E+
Sbjct: 383 GHVGA---------------------LNDEAGKEV------------------------- 396
Query: 477 MKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNN 536
SP+F Q+LDC+ Q++ Q P F+FNER+L + H+YSCQ+GTFI + + +R N
Sbjct: 397 ----SPIFTQWLDCIWQIMQQKPRAFQFNERYLIEMHEHVYSCQFGTFIGNCDKDRRDLN 452
Query: 537 AFHQTRSVWDYFRSRTHEFSNPNY 560
+T+S+W + +R ++ NP Y
Sbjct: 453 LSKRTKSLWTWMDARHDDYMNPFY 476
>Hs4557896 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 603
Score = 283 bits (723), Expect = 7e-76
Identities = 170/478 (35%), Positives = 255/478 (52%), Gaps = 73/478 (15%)
Query: 86 FNIKVITKDYNIFSLDLENEKNTQ-DVYDSLCKLTI-LDDVHKLYAFIYSPNKAETPFNS 143
+ + + KD L+ E +++ D+++ L + L L+AF+ N+ + +
Sbjct: 107 YGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFL---NEEKFNVDG 163
Query: 144 WNIYDPVKEFERQGLNFGDEECCKWRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVK 203
W +Y+PV+E+ RQGL WR++ IN+ Y C TYP+ LVVP SD +
Sbjct: 164 WTVYNPVEEYRRQGLPNHH-----WRITFINKCYELCDTYPALLVVPYRASDDDLRRVAT 218
Query: 204 YRSQQRIPALTYYYAKNGASITRCAQPLPGITQQRSIQDEKLIREIFNCSINKTSKNIIV 263
+RS+ RIP L++ + +N I RC+QPL G++ +R+ DEK + ++ + + SK I
Sbjct: 219 FRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYL-DVIRETNKQISKLTIY 277
Query: 264 DARPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDL 323
DARP+ NA+A A GGG E+ D Y FL I NIHVMR+SL + D +
Sbjct: 278 DARPSVNAVANKATGGGYESDDAY---HNAELFFLDIHNIHVMRESLKKVKDI------V 328
Query: 324 YLPIDKS-MLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSL 382
Y +++S L+S +S+ WL++IKL+L+ + + S++LVHCSDGWDRTAQ+TSL
Sbjct: 329 YPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSL 388
Query: 383 VQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXX 442
L LD +YR+IEGF +LV+K+W++FGH+F R GH
Sbjct: 389 AMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGH------------------------ 424
Query: 443 XNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQF 502
DK + SP+F QF+DCV Q+ Q+PT F
Sbjct: 425 -GDKNHTDADR---------------------------SPIFLQFIDCVWQMSKQFPTAF 456
Query: 503 EFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSVWDYFRSRTHEFSNPNY 560
EFNE+FL ++ HLYSC++GTF+F+ E R +T S+W S +F NP Y
Sbjct: 457 EFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFY 514
>7297058 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 619
Score = 262 bits (670), Expect = 1e-69
Identities = 150/436 (34%), Positives = 231/436 (52%), Gaps = 69/436 (15%)
Query: 126 KLYAFIYSPNKAETP---FNSWNIYDPVKEFERQGLNFGDEECCKWRVSDINEDYSFCRT 182
+L+AF ++ + ++ W +Y+P+ E R G+ WR + +NE Y+ C +
Sbjct: 165 RLFAFAHAAANSVNGNGGWDGWAVYEPLAELRRLGVPND-----MWRATKLNESYAICDS 219
Query: 183 YPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRCAQPLPGITQQRSIQD 242
YP+ VPK SD + ++RS+ R+P L++ + A+ITRC+QPL G++ +R+ D
Sbjct: 220 YPAVWAVPKAASDDFLRRVAQFRSRCRLPVLSWMNPRTQATITRCSQPLVGVSGKRNSDD 279
Query: 243 EKLIREIFNCSINKTSKNIIVDARPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDN 302
E + I + ++ K I+DARP+ NA+A A GGG E+ D Y + FL I N
Sbjct: 280 EAYLSFIMEANA-QSDKLTIMDARPSANAIANKAKGGGYESEDAY---KNVEINFLDIHN 335
Query: 303 IHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNN 362
IHVMR+SL + + D D + ++ WLK+I+ +L+ +V + +
Sbjct: 336 IHVMRESLRKVKEACFPTTD-----DSKWQTAIDNTLWLKHIRCILAGAVRIVDKVETMS 390
Query: 363 SNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSH 422
++++VHCSDGWDRTAQ+T+L L LDP+YRT+ GF VL+EK+WL+FGH+F +R GH
Sbjct: 391 TSVVVHCSDGWDRTAQLTALSMLLLDPHYRTVRGFEVLIEKEWLSFGHKFQQRIGH---- 446
Query: 423 SVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSP 482
D K ++ SP
Sbjct: 447 ---------------------GDNKHSDADR---------------------------SP 458
Query: 483 VFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTR 542
VF QF+D V Q+ Q+ FEFNE FL +V HLYSC++GTF+ + E ERV + H+T
Sbjct: 459 VFLQFIDSVWQVSQQFNNAFEFNEHFLITIVDHLYSCRFGTFLCNTEAERVAEDLKHKTT 518
Query: 543 SVWDYFRSRTHEFSNP 558
S+W + S ++ NP
Sbjct: 519 SLWTHINSSLDQYLNP 534
>CE24125 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 592
Score = 248 bits (633), Expect = 2e-65
Identities = 183/616 (29%), Positives = 284/616 (45%), Gaps = 102/616 (16%)
Query: 4 IKIARVDNVIWHKRGIS-------LKGSLHLTTHHLIFT--DDNSSREFWVAYPTIASVF 54
+K+ +++IW ++ ++ G + +T + ++F D E W + V
Sbjct: 30 LKLLAAESLIWTEKNVTYFGPLGKFPGKIVITRYRMVFLVGDGGKMYEQWKLDIPLGQV- 88
Query: 55 KNKGSSLISKYKHHSEWEKEALYAGKDIWMFFNIKVITKDYNIFSLDLEN-EKNTQDVYD 113
S+ + G D + F + KDY ++ + ++V D
Sbjct: 89 --------SRIEKVGRKTTSVAKRGDDNYGF---TIYCKDYRVYRFTCNPASSDRKNVCD 137
Query: 114 SLCKLTILDDVHKLYAFIYSPNKAETPF---NSWNIYDPVKEFERQGLNFGDEECCKWRV 170
SL + H L F S + AETP + W IY KE+ER G+ W+
Sbjct: 138 SLNRYAFPLS-HNLPMFA-SVHAAETPRLMKDGWKIYSAEKEYERLGI----PNSRLWKE 191
Query: 171 SDINEDYSFCRTYPSKLVVPKTVS----DTLISYSVKYRSQQRIPALTYYYAKNGASITR 226
DIN+DY F TYP V+P TVS + ++RS++RIP L++ ASI+R
Sbjct: 192 VDINKDYKFSETYPRTFVIP-TVSWEEGKPFVKKLGEFRSKERIPVLSWINQTTLASISR 250
Query: 227 CAQPLPGITQQRSIQDEKLIREIFNCSINKTSKNIIVDARPTTNAMAQTALGGGTENMDN 286
C+QP+ GI+ +RS +DE+ + I N + N + +I+DARP NA A GGG E +N
Sbjct: 251 CSQPMTGISGKRSAEDERHLTNIMNANAN-CRELLILDARPAVNAKLNKAKGGGYE--EN 307
Query: 287 YGFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYIKL 346
Y FL I NIHV+RDSL L+ + D +K + S WL +++
Sbjct: 308 Y---VNAPLTFLNIHNIHVVRDSLKRLLAALIPRVD-----EKGYYKALDESKWLNHVQS 359
Query: 347 LLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWL 406
+L V ++ ++L+HCSDGWDRTAQ+TSL + LD YYRTIEGF+VL+EK+W
Sbjct: 360 ILEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWC 419
Query: 407 AFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISS 466
+FGH+F E RI
Sbjct: 420 SFGHKFGE------------------------------------------------RIGH 431
Query: 467 TFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIF 526
+ +G SPVF QF DC+ Q++ Q+P FEF + L ++ LY+C+YGTF++
Sbjct: 432 GDDNYSDGER----SPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFLY 487
Query: 527 DNEYERVTNNAFHQTR-SVWDYFRSRTHEFSNPNYREPSDDEEDWILPDWEKVEWWWQLF 585
++E R+ + +T S W Y +F NP ++ ++ + P + W +
Sbjct: 488 NSEKIRLKDKKCDETTISFWSYVLENKKKFRNPMFKHGKSNKVINVNPSLCGLHVWIDYY 547
Query: 586 GRRDAEMNGPCPTHED 601
R + + P HED
Sbjct: 548 ARSNPYV--VTPNHED 561
>Hs10863893 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 1195
Score = 241 bits (614), Expect = 3e-63
Identities = 152/438 (34%), Positives = 210/438 (47%), Gaps = 100/438 (22%)
Query: 168 WRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRC 227
WRVS IN +Y C +YP KL+VP ++D + +RS +RIP + Y + +NGA+I RC
Sbjct: 174 WRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARC 233
Query: 228 AQPLPGITQQRSIQDEKLIREI-------------------------------FNCSINK 256
+QP R+ DE L+ I F+ S+
Sbjct: 234 SQPEISWWGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTA 293
Query: 257 TS---------KNIIVDARPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDNIHVMR 307
S K +I+DAR T A+A A GGG E + Y C +F+G+ NIH +R
Sbjct: 294 CSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYY---PNCEVVFMGMANIHAIR 350
Query: 308 DSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILV 367
+S YL +P + L++ +S+ WL+++ ++L + + ++ +LV
Sbjct: 351 NSFQYLRAVCS-----QMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLV 405
Query: 368 HCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHD 427
HCSDGWDRT QI +L ++ LDPYYRT+EGF VLVE DWL FGH+F +R GH
Sbjct: 406 HCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGH--------- 456
Query: 428 NSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQF 487
N + +NE PVF Q+
Sbjct: 457 --------------QENVEDQNE-----------------------------QCPVFLQW 473
Query: 488 LDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSVWDY 547
LD VHQLL Q+P FEFNE FL +LV H YSC YGTF+ +N ER N + +T SVW
Sbjct: 474 LDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWAL 533
Query: 548 FRSRTHEFSNPNYREPSD 565
R+ F N Y SD
Sbjct: 534 LRAGNKNFHNFLYTPSSD 551
>Hs19923424 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 549
Score = 239 bits (611), Expect = 7e-63
Identities = 176/591 (29%), Positives = 275/591 (45%), Gaps = 104/591 (17%)
Query: 2 DYIKIARVDNVIWHKRGI-SLKGSLHLTTHHLIFTD-DNSSREFWVAYPTIASVFKNKGS 59
+ IK RVDNV+ H+ +++G+L LT HHLI + +++ E W+ + I ++ K
Sbjct: 5 ELIKTPRVDNVVLHRPFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDKRFVG 64
Query: 60 SLISKYKHHSEWEKEALYAGKDIWMFFNIKVITKDYNIFSLDLENEKNTQDVYDSLCKLT 119
SL + I + KD+ I LD+ + ++ S+ L+
Sbjct: 65 SLGT------------------------IIIKCKDFRIIQLDIPGMEECLNIASSIEALS 100
Query: 120 ILDDVHKLYAFIYSPNKAETPFNSWNIYDPVKEFERQGLNFGDEECCKWRVSDINEDYSF 179
LD + +Y F Y P E + W+ + P +EFE +WR+S +N++++
Sbjct: 101 TLDSITLMYPFFYRP-MFEVIEDGWHSFLPEQEFELYS-----SATSEWRLSYVNKEFAV 154
Query: 180 CRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRCAQPLPGITQQRS 239
C +YP + VPK++ D + +R R P L+YY+ KNG I R QPL G +R
Sbjct: 155 CPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRC 214
Query: 240 IQDEKLIREIFNCSINKTSKNIIVDARPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLG 299
+DEKLI N ++ + I+D R A A GGG E +Y R+
Sbjct: 215 KEDEKLI----NATLRAGKRGYIIDTRSLNVAQQTRAKGGGFEQEAHY---PQWRRIHKS 267
Query: 300 IDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIV 359
I+ H++++SL LV+ ND +D+ L+ ++S+WL +IK +L++ + I
Sbjct: 268 IERYHILQESLIKLVE---ACNDQTHNMDR-WLSKLEASNWLTHIKEILTTACLAAQCID 323
Query: 360 FNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHL 419
++IL+H ++G D T Q+TSL Q+ L+P RTI GF L+E++WL GH F +R
Sbjct: 324 REGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQ- 382
Query: 420 SSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKL 479
N K++ E
Sbjct: 383 --------------------SAYCNTKQKWE----------------------------- 393
Query: 480 TSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFH 539
+PVF FLDCV Q+L Q+P FEFNE FL L H Y+ Q+GTF+ +NE ER
Sbjct: 394 -APVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQ 452
Query: 540 QTRSVWDYFR--SRTHEFSNPNYRE------PSDDEEDWILPDWEKVEWWW 582
+T S+W + S +F+NP + PS + LP WE + W
Sbjct: 453 KTMSLWSWVNQPSELSKFTNPLFEANNLVIWPSVAPQS--LPLWEGIFLRW 501
>Hs10835109 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 1198
Score = 237 bits (605), Expect = 3e-62
Identities = 155/458 (33%), Positives = 215/458 (46%), Gaps = 108/458 (23%)
Query: 152 EFERQGLNFGDEECCKWRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIP 211
E ER G + + WR+S+INE Y C +YP +L+VP ++D + +RS +RIP
Sbjct: 164 EVERMGFDMNNA----WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIP 219
Query: 212 ALTYYYAKNGASITRCAQPLPGITQQRSIQDEKLIREI---------------------- 249
A+ Y + NGA I RC QP R+ DE L++ +
Sbjct: 220 AVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSR 279
Query: 250 ------------FNCSINKTS----------KNIIVDARPTTNAMAQTALGGGTENMDNY 287
F+ S++ S K +I+DAR A+A A GGG E + Y
Sbjct: 280 DFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYY 339
Query: 288 GFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYIKLL 347
C +F+G+ NIH +R S L L +P + L++ +S+ WL ++ +L
Sbjct: 340 ---PNCEVVFMGMANIHSIRRSFQSL--RLLCTQ---MPDPGNWLSALESTKWLHHLSVL 391
Query: 348 LSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLA 407
L S +V ++ + +LVHCSDGWDRT QI +L +L LDPYYRTIEGF VLVE +WL
Sbjct: 392 LKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLD 451
Query: 408 FGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISST 467
FGH+F +R GH GE
Sbjct: 452 FGHKFADRCGH---------------------------------GE-------------- 464
Query: 468 FKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFD 527
N ++ PVF Q+LDCVHQL Q+P FEFNE FL +LV H YSC +GTF+ +
Sbjct: 465 -----NSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCN 519
Query: 528 NEYERVTNNAFHQTRSVWDYFRSRTHEFSNPNYREPSD 565
N ER + +T SVW R+ F N Y S+
Sbjct: 520 NAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSE 557
>At3g10550 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 609
Score = 215 bits (547), Expect = 2e-55
Identities = 142/425 (33%), Positives = 205/425 (47%), Gaps = 78/425 (18%)
Query: 168 WRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRC 227
WR+SD+N +Y+ C+TYP ++PK++SD + + +R++ R+P +T+ +GA I R
Sbjct: 16 WRISDLNSNYNLCQTYPFAFMIPKSISDAELLQACSFRARCRLPVITWCQPGSGAVIARS 75
Query: 228 AQPLPGI-TQQRSIQDEKLIREIFNCS-----INKTSKNIIVDARPTTNAMAQTALGGGT 281
+QPL G+ RS DEKL+ CS + K I DARP NA+A A+GGG+
Sbjct: 76 SQPLVGLMMNMRSNLDEKLVAAF--CSQLPGAKGERRKLYIADARPRKNALANGAMGGGS 133
Query: 282 ENMDNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLN-------- 333
E+ NY ++ +F GIDNIH MR+S + + D + S L
Sbjct: 134 ESSSNYFQSEI---VFFGIDNIHAMRESFSRVRDYLDMHGTTSSDGRSSFLRHGGWTWGG 190
Query: 334 ---SDKSSS--------WLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSL 382
S S+S WL +I+ +L+ + + ++++LVHCSDGWDRT Q+ SL
Sbjct: 191 GNLSSMSASVSLLGDSGWLIHIQSVLAGAAWIAARVAMESASVLVHCSDGWDRTTQLVSL 250
Query: 383 VQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXX 442
L LDPYYRT GF LVEKDWLAFGH F +R G
Sbjct: 251 ACLLLDPYYRTFAGFQALVEKDWLAFGHPFSDRVG------------------------- 285
Query: 443 XNDKKENELGEFSTMTSPETRISSTFKKFRNGTN-MKLTSPVFQQFLDCVHQLLIQYPTQ 501
P S F R+ ++ SP+F Q++D V QL+ YP
Sbjct: 286 ----------------MPNISGSGNFDFPRHSSHGHNNYSPIFMQWIDSVSQLMRMYPCA 329
Query: 502 FEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSVWDY------FRSRTHEF 555
FEF+ FL + L SC++G F+ ++E ER +W Y F + +H
Sbjct: 330 FEFSPTFLVDFMDCLLSCRFGNFLCNSEKEREQCGIADACGCLWAYLTDLRSFSATSHVH 389
Query: 556 SNPNY 560
NP Y
Sbjct: 390 CNPFY 394
>7293198 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 862
Score = 199 bits (506), Expect = 1e-50
Identities = 129/428 (30%), Positives = 200/428 (46%), Gaps = 118/428 (27%)
Query: 152 EFERQGLNFGDEECCKWRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIP 211
+F+ + G + WR+S N D+ C +YP KL+VP ++D ++ +R +R+P
Sbjct: 212 DFKNEVARLGFDLKGSWRISTANADFKLCPSYPPKLLVPCCITDEMLHNVANFRGSRRLP 271
Query: 212 ALTYYYAKNGASITRCAQPLPGITQQRSIQDEKLIREIFNC------------------- 252
A+ + + K+GA + RC+QP G R+ +DE+L++ + +
Sbjct: 272 AVVWRHQKSGAILARCSQPEVGWLGWRNTRDEQLLKALADACAFDRGEHARHSTCANAKA 331
Query: 253 -------------------------------SINKTSKNIIVDARPTTNAMAQTALGGGT 281
++++ K +IVDAR T+A+ A GGG
Sbjct: 332 QPTKGSKETNGQSGLSGKSSPSLDDSSHEELTLDEIKKILIVDARSYTSAVTNRARGGGC 391
Query: 282 ENMDNYGFNQTCSRM-FLGIDNIHVMRDSLN---YLVDNFLVDNDLYLPIDKSMLNSDKS 337
E ++ Y C+ + F+ + NIH +R S + L + D + Y ++K+M
Sbjct: 392 ECIEYY----PCAEIEFMNLGNIHAIRKSFHAVRQLCASSPDDPNWYGQLEKTM------ 441
Query: 338 SSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGF 397
W++++ LL +T T+V +I N +LVHCSDGWDRT QI + QL LDPYYRT+EGF
Sbjct: 442 --WMQHLSGLLGATMTVVHTIEKNGRPVLVHCSDGWDRTPQIVATAQLCLDPYYRTVEGF 499
Query: 398 MVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTM 457
VLVE++WL FGH+F +RSG N +E+ E
Sbjct: 500 RVLVEREWLNFGHKFADRSG--------------------------NGPNSDEVNE---- 529
Query: 458 TSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLY 517
PVF Q+LD VHQ+ QYP FEF+ +L +L H
Sbjct: 530 ----------------------RCPVFLQWLDLVHQIHRQYPCSFEFSISYLIKLAQHSL 567
Query: 518 SCQYGTFI 525
SC +GTF+
Sbjct: 568 SCLFGTFL 575
>Hs14751578 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 334
Score = 196 bits (498), Expect = 9e-50
Identities = 110/300 (36%), Positives = 159/300 (52%), Gaps = 61/300 (20%)
Query: 262 IVDARPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDN 321
+VD RP NAMA A G G EN DNY F+GI+NIHVMR+SL +++
Sbjct: 17 VVDTRPKLNAMANRAAGKGYENEDNYS---NIKFQFIGIENIHVMRNSLQKMLEVC---- 69
Query: 322 DLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITS 381
+L P L ++S WL++IK ++ + + K++ +++LVHCSDGWDRTAQ+ S
Sbjct: 70 ELKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCS 129
Query: 382 LVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXX 441
+ L LDP+YRT++GFMVL+EKDW++FGH+F R G+L
Sbjct: 130 VASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLD--------------------- 168
Query: 442 XXNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQ 501
D KE SPV QF++CV QL+ Q+P
Sbjct: 169 --GDPKE-------------------------------ISPVIDQFIECVWQLMEQFPCA 195
Query: 502 FEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSVWDYFRSRTHEFSNPNYR 561
FEFNERFL + +H+YSCQ+G F+ +++ ER +T S+W + ++ NP +R
Sbjct: 196 FEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFR 255
>At5g04540 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 799
Score = 194 bits (492), Expect = 4e-49
Identities = 144/491 (29%), Positives = 225/491 (45%), Gaps = 78/491 (15%)
Query: 106 KNTQDVYDSLCKLTILDDVHKLYAFIYSPNKAETPFNSWNIYDPV---------KEFERQ 156
K V D+L + + V LYAF P++ F + N + + K +R
Sbjct: 147 KQRHTVVDTLLRCNKPERVWDLYAFTCGPSQ----FGNTNPKERLLNEYFRLLGKSSQRA 202
Query: 157 GLNFGDEECCK-----WRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIP 211
+N ++ WR++++N +Y C++YP L+VPK++SD + + +R++ R+P
Sbjct: 203 SMNMIEDGSFTLSNDLWRITNLNSNYDLCQSYPFALMVPKSISDEELLQTSTFRARCRLP 262
Query: 212 ALTYYYAKNGASITRCAQPLPGITQQ-RSIQDEKLIREIFNCSINKTS---KNIIVDARP 267
+++ + +GA I R +QPL G+ RS DEKL+ K IVDARP
Sbjct: 263 VISWCHPGSGAVIARSSQPLVGLMMNMRSNSDEKLVASFCTQLAGHKGARRKLYIVDARP 322
Query: 268 TTNAMAQTALGGGTENMDNYGFNQTCSRMFL-------GIDNIHVMRDSLNYLVDNFLVD 320
NA+A A GGG+E+ NY ++ C+ + G N+ M S++ L D
Sbjct: 323 RKNALANGAKGGGSESSSNYLQSEVCTWPKVRHGGWTWGGGNLSSMSASVSVLGD----- 377
Query: 321 NDLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQIT 380
S WL +I+ +L+ + + ++++LVHCSDGWDRT Q+
Sbjct: 378 -----------------SGWLSHIQSILAGVAWIAARVAMESASVLVHCSDGWDRTTQLV 420
Query: 381 SLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXX 440
SL L LDPYYRT GF LVEKDWL+FGH F +R G +V +
Sbjct: 421 SLACLLLDPYYRTFSGFQALVEKDWLSFGHPFSDRVG---MPNVSESGNFELPIQSSSAR 477
Query: 441 XXXNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPT 500
+ G + +S SS++ + SP+F Q+LDC+ QL+ YP+
Sbjct: 478 SFPSSPVRQSPGSAAAQSS-----SSSY-------GLNNYSPIFLQWLDCISQLMRMYPS 525
Query: 501 QFEFNERFLRRLVYHLYSCQYGTFIFD-NEYERVTNNAFHQTRSVWDYF------RSRTH 553
FEF+ + +S TF+ + +E ER +W Y +H
Sbjct: 526 AFEFSP----EVTMSHFSIYINTFLINCSEKERQQCGISETCGCIWAYLADLRSSSGTSH 581
Query: 554 EFSNPNYREPS 564
NP Y +PS
Sbjct: 582 VHCNPFY-DPS 591
>CE28087 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 1006
Score = 193 bits (490), Expect = 8e-49
Identities = 127/402 (31%), Positives = 195/402 (47%), Gaps = 69/402 (17%)
Query: 168 WRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRC 227
+++S +NE++ C TYP K++VPK ++D I YRS R PA+ + K A + R
Sbjct: 268 FQISSVNENFEVCPTYPEKIIVPKGITDDDIRKGAPYRSIGRFPAVIWRCRKTRAVLMRS 327
Query: 228 AQPLPGITQQRSIQDEKLIREIFNCSI---NKTSKNIIVDARPTTNAMAQTALGGGTENM 284
+QP GI R+ DEK+I E S + + II+DAR T+A A A GG EN
Sbjct: 328 SQPQVGILSWRNPTDEKIIEEAVKASRIEGEEKKQFIIMDARGYTSAFANRARSGGFENT 387
Query: 285 DNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYI 344
+ Y Q FLG+ NIH +R S N + ++ N L ++ +L S +++ WL +
Sbjct: 388 EYY---QQAKLEFLGLPNIHAVRGSFNNV--RTMLHN---LGPNEQLLTSLQTTGWLLNL 439
Query: 345 KLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKD 404
LL + + +S +LVHCSDGWDRT Q+T+L ++ LD YYRT++GF L+ +D
Sbjct: 440 SNLLVNAANCADHLSKGHS-VLVHCSDGWDRTTQVTTLAKIMLDEYYRTVKGFEELIRRD 498
Query: 405 WLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRI 464
W+AFGH+ +R +L F + + R
Sbjct: 499 WIAFGHKLYDR----------------------------------QLVAFGNWGTSDER- 523
Query: 465 SSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTF 524
SPVF QFL+ V L + PT F+F +L +L H YS +G+F
Sbjct: 524 ----------------SPVFLQFLEAVRHLQREQPTLFQFTHAYLIKLAKHAYSGLFGSF 567
Query: 525 IFDNEYERVTNNAFHQTR----SVWDYFRSRTHEFSNPNYRE 562
+F++ ER A + + +W + E+ N ++ E
Sbjct: 568 LFNSHKER--REAMEKCKGTLVDIWRFIGPHNEEYVNQSFDE 607
>CE03708 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 938
Score = 193 bits (490), Expect = 8e-49
Identities = 127/402 (31%), Positives = 195/402 (47%), Gaps = 69/402 (17%)
Query: 168 WRVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRC 227
+++S +NE++ C TYP K++VPK ++D I YRS R PA+ + K A + R
Sbjct: 264 FQISSVNENFEVCPTYPEKIIVPKGITDDDIRKGAPYRSIGRFPAVIWRCRKTRAVLMRS 323
Query: 228 AQPLPGITQQRSIQDEKLIREIFNCSI---NKTSKNIIVDARPTTNAMAQTALGGGTENM 284
+QP GI R+ DEK+I E S + + II+DAR T+A A A GG EN
Sbjct: 324 SQPQVGILSWRNPTDEKIIEEAVKASRIEGEEKKQFIIMDARGYTSAFANRARSGGFENT 383
Query: 285 DNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYI 344
+ Y Q FLG+ NIH +R S N + ++ N L ++ +L S +++ WL +
Sbjct: 384 EYY---QQAKLEFLGLPNIHAVRGSFNNV--RTMLHN---LGPNEQLLTSLQTTGWLLNL 435
Query: 345 KLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKD 404
LL + + +S +LVHCSDGWDRT Q+T+L ++ LD YYRT++GF L+ +D
Sbjct: 436 SNLLVNAANCADHLSKGHS-VLVHCSDGWDRTTQVTTLAKIMLDEYYRTVKGFEELIRRD 494
Query: 405 WLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRI 464
W+AFGH+ +R +L F + + R
Sbjct: 495 WIAFGHKLYDR----------------------------------QLVAFGNWGTSDER- 519
Query: 465 SSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTF 524
SPVF QFL+ V L + PT F+F +L +L H YS +G+F
Sbjct: 520 ----------------SPVFLQFLEAVRHLQREQPTLFQFTHAYLIKLAKHAYSGLFGSF 563
Query: 525 IFDNEYERVTNNAFHQTR----SVWDYFRSRTHEFSNPNYRE 562
+F++ ER A + + +W + E+ N ++ E
Sbjct: 564 LFNSHKER--REAMEKCKGTLVDIWRFIGPHNEEYVNQSFDE 603
>HsM8923126_1 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 271
Score = 179 bits (454), Expect = 1e-44
Identities = 93/265 (35%), Positives = 140/265 (52%), Gaps = 58/265 (21%)
Query: 297 FLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVK 356
F+GI+NIHVMR SL L++ +L P L+ +SS WL++IK ++ + + K
Sbjct: 36 FMGIENIHVMRSSLQKLLEVC----ELKTPTMSEFLSGLESSGWLRHIKAIMDAGIFITK 91
Query: 357 SIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERS 416
++ +++LVHCSDGWDRTAQ+ S+ + LDP+YRT +G M+L+EK+W++ GH+F +R
Sbjct: 92 AVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRC 151
Query: 417 GHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRISSTFKKFRNGTN 476
GHL D KE
Sbjct: 152 GHLD-----------------------GDSKE---------------------------- 160
Query: 477 MKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNN 536
SP+F QFLDC+ QL+ Q+P FEFNE FL + H++SCQ+G F+ + + +R
Sbjct: 161 ---VSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLR 217
Query: 537 AFHQTRSVWDYFRSRTHEFSNPNYR 561
+ +T SVW + R +F NP Y+
Sbjct: 218 VYEKTHSVWPFLVQRKPDFRNPLYK 242
>CE26073 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 569
Score = 176 bits (445), Expect = 1e-43
Identities = 158/604 (26%), Positives = 259/604 (42%), Gaps = 113/604 (18%)
Query: 2 DYIKIARVDNVIWHKRGISLK-GSLHLTTHHLIFTDD-------NSSREFWVAYPTIASV 53
+ I++ RV + K + G + + HHLIF +++ EFW+ + + V
Sbjct: 5 ELIEVTRVRDAFMRKGPRPAQVGDICIFGHHLIFAPTTVGKEVPDNAEEFWLLHKAVDRV 64
Query: 54 FKNKGSSLISKYKHHSEWEKEALYAGKDIWMFFNIKVITKDYNIFSLDLENEKNTQDVYD 113
ISK ++ AL + + F I DLE + T +
Sbjct: 65 LCEP----ISK-ENPQRGGLLALKCKNFLLIIFEIG-----------DLEICRATARTIE 108
Query: 114 SLCKLT-ILDDVHKLYAFIYSPNKAETPF----NSWNIYDPVKEFERQGLNFGDEECCKW 168
SL + L D YAF Y+ +PF + W+ +D +EF R L+ +
Sbjct: 109 SLSNINGFLHD----YAFFYN-----SPFTILDDGWSAFDLEQEFARLMLSTD-----AF 154
Query: 169 RVSDINEDYSFCRTYPSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRCA 228
R+S +NE+++ C TYP KL+VPK + D + S +R R P L+Y++ + + + RC+
Sbjct: 155 RISSVNENFAICPTYPEKLIVPKGIGDDYLKISATFREGGRFPVLSYFHKETKSPLVRCS 214
Query: 229 QPLPGITQQRSIQDEKLIREIFNCSINKTSKNIIVDARPTTNAMAQTALGGGTENMDNYG 288
QPL G T +R +DE ++ S+ ++ I+D R ++A A A GGG E NY
Sbjct: 215 QPLIGPTNRRCREDETILN-----SMITVNRGYIIDTRSKSSATAAKAKGGGAEPQGNY- 268
Query: 289 FNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYLPIDKSMLNSDKSSSWLKYIKLLL 348
+ + I + D+L +VD V ++ + D+ ++ + WL + L
Sbjct: 269 --RQWRYIQCPIPRQREIHDALTRMVD---VCSERKVTSDR-WVSRVGQAGWLSSVAASL 322
Query: 349 SSTDTLVKSIV---FNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDW 405
+ + + I +++H DG D T +SL Q+ LD RTI GF ++E++W
Sbjct: 323 EAAANVAQCIYNERLEEVPVVIHGGDGLDSTLIASSLAQILLDADARTIRGFESVIEREW 382
Query: 406 LAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFSTMTSPETRIS 465
+ GH F R+ H + T+T P
Sbjct: 383 ICGGHPFSLRNNHCAYAE-------------------------------GTVTGP----- 406
Query: 466 STFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFI 525
SPVF FLD VHQ++ QYP FEF+E FL L H Y+ ++G+F+
Sbjct: 407 -------------FESPVFLVFLDAVHQMIAQYPMSFEFDENFLIFLFEHAYASEFGSFL 453
Query: 526 FDNEYERVTNNAFHQTRSVWDYFR--SRTHEFSNPNYREPSDDEEDWILPD----WEKVE 579
+ E E+ N +T S+W + +F N Y I P W+++
Sbjct: 454 GNCEKEKKDNGIRKKTVSLWSHVHHPENMKQFVNVCYDPTPGVIWPSIAPQCIKIWDRLF 513
Query: 580 WWWQ 583
+ WQ
Sbjct: 514 FRWQ 517
>7295015 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 593
Score = 162 bits (411), Expect = 1e-39
Identities = 166/663 (25%), Positives = 270/663 (40%), Gaps = 127/663 (19%)
Query: 2 DYIKIARVDNVIWH---KRGIS--LKGSLHLTTHHLIFTD-DNSSREFWVAYPTIASVFK 55
D IK ++D V+ H G S G+L +T HHL+ + +S+E W+ + I V K
Sbjct: 5 DLIKTPKLDGVLLHDPSNAGASGATVGTLCITGHHLLLSARQETSQELWLLHKNIDCVEK 64
Query: 56 NKGSSLISKYKHHSEWEKEALYAGKDIWMFFNIKVITKDYNIFSLDLENEKNTQDVYDSL 115
S ++I + I + KD I SL+++ K +V SL
Sbjct: 65 KPSLS-------------------QNIVVGGIITLKCKDLRIISLEIKCGKEFFNVAASL 105
Query: 116 CKLTILDDVHKLYAFIYSPNKAETPFNSWNIYDPVKEFERQGLNFGDEECCKWRVSDIN- 174
L+ + + LY F Y P + + + ++ P EF + G V++I
Sbjct: 106 EALSAIQNTELLYPFFYRPMYSILE-DGYTMFRPELEFAKLISGVGMGGASSPNVANITI 164
Query: 175 -----------------------------EDYSFCRTYPSKLVVPKTVSDTLISYSVKYR 205
D+S C TY + L+VPK ++D I S +R
Sbjct: 165 CMPSTSTSTLTVGAGIPHPLQNGYAIEALADFSVCATYGATLIVPKAITDEQIVLSAAFR 224
Query: 206 SQQRIPALTYYYAKNGASITRCAQPLPGITQQRSIQDEKLIREIFNCSINKTSKNIIVDA 265
R P L+Y + +NGA++ R +QPL +R DE ++ N + ++ K IVD
Sbjct: 225 DGGRFPVLSYRH-ENGATLMRSSQPLSIQGIKRCRADEAIL----NLVLGRSRKGFIVDT 279
Query: 266 RPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDNFLVDNDLYL 325
+ +T L +Y + +R + + + DS L++ NDL
Sbjct: 280 WGKGKSNTETDL--------HYSQWKKVNRSIGNVSSPASILDSFARLIE---ACNDLGC 328
Query: 326 PIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQL 385
DK L+ ++S WL + L+++ + + + S +LVH + G D T +TSLVQ+
Sbjct: 329 STDK-WLSRLENSGWLSLVLNSLNASCVVAQCLDQEGSPVLVHGAKGLDSTLIVTSLVQI 387
Query: 386 SLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXND 445
L+P RT+ G L+E++W+ GH F R +S + N TR
Sbjct: 388 ILNPDCRTVRGLQALIEREWIQAGHPFASR----HRYSCYTPNQTRN------------- 430
Query: 446 KKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFN 505
K + F FLDC++QL Q+P FEF+
Sbjct: 431 --------------------------------KTSGATFVLFLDCIYQLYTQFPCSFEFS 458
Query: 506 ERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSVWDYFR--SRTHEFSNPNYREP 563
+ L L H + QYGTF+ D+E ER N +T S+W Y F NP Y
Sbjct: 459 TQLLILLFEHSHFSQYGTFLCDSERERNELNVHTRTTSLWSYLNRPDVLQTFLNPLYEPN 518
Query: 564 SDDEEDWILPDWEKVEWWWQLFGRRDAEMNGPCPTHEDEDTLVKKTNTI-VSSLKMPKFS 622
++ + P +E W L+ R + LV + + +LK+ K +
Sbjct: 519 ANVIWPSVAP--ISLELWSDLYLRWVIDQRSSVTVMSQIQELVTREKELRTQALKLRKQA 576
Query: 623 LEI 625
+E+
Sbjct: 577 MEL 579
>Hs22069399 [R] KOG1090 Predicted dual-specificity phosphatase
Length = 1531
Score = 136 bits (342), Expect = 1e-31
Identities = 90/255 (35%), Positives = 121/255 (47%), Gaps = 68/255 (26%)
Query: 326 PIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQL 385
P S L S + S WL I LL LV ++ + S++LV DGWD T Q+ SLVQL
Sbjct: 1043 PSPASFLRSLEDSEWLIQIHKLLQ-VSVLVVELLDSGSSVLVGLEDGWDITTQVVSLVQL 1101
Query: 386 SLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXND 445
DP+YRT+EGF +LVEK+WL+FGHRF R H +
Sbjct: 1102 LSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLA------------------------ 1137
Query: 446 KKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFN 505
G+ S T PVF QFLDCVHQ+ +Q+P +FEF+
Sbjct: 1138 ------GQSSGFT-----------------------PVFLQFLDCVHQVHLQFPMEFEFS 1168
Query: 506 ERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQ----------TRSVWDY---FRSRT 552
+ +L+ L YH S ++ TF+ D++YER+ ++ RSVW+Y RT
Sbjct: 1169 QFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRT 1228
Query: 553 HEFSNPNYREPSDDE 567
F N Y P D E
Sbjct: 1229 PVFHNYMY-APEDAE 1242
>7299513 [R] KOG1090 Predicted dual-specificity phosphatase
Length = 1993
Score = 127 bits (320), Expect = 4e-29
Identities = 74/197 (37%), Positives = 99/197 (49%), Gaps = 51/197 (25%)
Query: 336 KSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDPYYRTIE 395
+ S WL+ I L+ + +V I S++++ DG D TAQ++S+ QL LDPYYR+++
Sbjct: 1421 EQSDWLQQISSLMQLSGAVVDLIDLQESSVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLD 1480
Query: 396 GFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXXXXNDKKENELGEFS 455
GF VLVEK+WLAFGHRF RS SH+
Sbjct: 1481 GFRVLVEKEWLAFGHRFAHRSNLKPSHA-------------------------------- 1508
Query: 456 TMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYH 515
TN+ +P F QFLD VHQL Q+P FEFN+ +LR L YH
Sbjct: 1509 ------------------NTNIAF-APTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYH 1549
Query: 516 LYSCQYGTFIFDNEYER 532
SC++ TF+FD E ER
Sbjct: 1550 SVSCRFRTFLFDCELER 1566
>Hs8923297 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 451
Score = 108 bits (271), Expect = 2e-23
Identities = 101/417 (24%), Positives = 179/417 (42%), Gaps = 104/417 (24%)
Query: 138 ETP-FNSWNIYDPVKEFERQGLNFGDEECCKWRVSDINEDYSFCRTYPSKLVVPKTVSDT 196
+TP F +++ +D +E +R G + WRV INE Y P +VVP +++D
Sbjct: 135 KTPLFETYSDWD--REIKRTGAS-------GWRVCSINEGYMISTCLPEYIVVPSSLADQ 185
Query: 197 LISYSVKYRSQQRIPALTYYYAKNGASITRCAQPLPGITQQRSIQDEKLIREIFNCSINK 256
+ +R+P + ++ NG+++ R A + + QQR I D+++
Sbjct: 186 DLKIFSHSFVGRRMPLWCWSHS-NGSALVRMAL-IKDVLQQRKI-DQRIC---------- 232
Query: 257 TSKNIIVDARPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDNIHVMRDSLNYLVDN 316
N I + P + + ++ L N+ Q F+ + + V
Sbjct: 233 ---NAITKSHPQRSDVYKSDLDKTLPNI------QEVQAAFVKLKQLCV----------- 272
Query: 317 FLVDNDLYLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRT 376
N+ + ++ L+S +++ WL+Y++ L + LV + + ++++ +G D +
Sbjct: 273 ----NEPFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLS 328
Query: 377 AQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXX 436
+ SLVQ+ LDPY+RTI GF L++K+W+ G++F +R HL
Sbjct: 329 CCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLK---------------- 372
Query: 437 XXXXXXXNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLI 496
+KE+ L F FLD QLL
Sbjct: 373 -------RSEKESPL--------------------------------FLLFLDATWQLLE 393
Query: 497 QYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQTRSV--WDYFRSR 551
QYP FEF+E +L L +GTF+F++ ++RV + + +S DYF SR
Sbjct: 394 QYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQSTVSRIKSCTKQDYFPSR 450
>7293003 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 843
Score = 88.2 bits (217), Expect = 3e-17
Identities = 76/251 (30%), Positives = 108/251 (42%), Gaps = 57/251 (22%)
Query: 328 DKSMLNSDK------SSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITS 381
+K ML DK ++WL Y+ L L ++ + +L S+G D I+S
Sbjct: 423 EKFMLQDDKYLGLLEKTNWLFYVSLCLRYASEASATLRSGVTCVLQE-SNGRDLCCVISS 481
Query: 382 LVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHLSSHSVFHDNSTRXXXXXXXXXX 441
L QL LDP++RTI+GF LV+K+W+A H F R GH+ N+
Sbjct: 482 LAQLLLDPHFRTIDGFQSLVQKEWVALEHPFQRRLGHVYPAQPAGGNA------------ 529
Query: 442 XXNDKKENELGEFSTMTSPETRISSTFKKFRNGTNMKLTSPVFQQFLDCVHQLLIQYPTQ 501
EL F + SP VF FLDCV QLL Q+P +
Sbjct: 530 --------EL--FDSEQSP----------------------VFLLFLDCVWQLLQQFPDE 557
Query: 502 FEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFHQ--TRSVWDYFRSRTHE----F 555
FEF + +L L + + TF FD + +R+ Q R VWD+ + + F
Sbjct: 558 FEFTQTYLTTLWDSCFMPIFDTFQFDTQAQRLKAVTDSQLVLRPVWDWGEQFSDKDKMFF 617
Query: 556 SNPNYREPSDD 566
SNP Y+ D
Sbjct: 618 SNPLYQRQRGD 628
>Hs9506679 [R] KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate
3-phosphatase MTM6
Length = 637
Score = 74.7 bits (182), Expect = 4e-13
Identities = 74/297 (24%), Positives = 120/297 (39%), Gaps = 46/297 (15%)
Query: 128 YAFIYSPNKAETPFNSWNIYDPVK----EFERQGLNFGDEECCKWRVSDINEDYSFCRTY 183
YA N P N ++D +K E ER N K++ +NE Y C
Sbjct: 186 YATAAQNNTVTVPKNHTVMFDTLKDWCWELERTKGNM------KYKAVSVNEGYKVCERL 239
Query: 184 PSKLVVPKTVSDTLISYSVKYRSQQRIPALTYYYAKNGASITRCAQPLPGITQQRSIQDE 243
P+ VVP + + + R Q + + NG+++ + + LP +Q +
Sbjct: 240 PAYFVVPTPLPEENVQ-----RFQGHGIPIWCWSCHNGSALLKMSA-LPKEQDDGILQIQ 293
Query: 244 KLIREIFNCSINKTSKNIIVDARPTTNAMAQTALGGGTENMDNYGFNQTCSRMFLGIDNI 303
K + +I++ I+ TE++ S FL + I
Sbjct: 294 KSFLDGIYKTIHRPPYEIVK-----------------TEDL---------SSNFLSLQEI 327
Query: 304 HVMRDSLNYLVDNFLVDNDL-YLPIDKSMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNN 362
L FL+DN + D + +SSSWL I+ L + + + N
Sbjct: 328 QTAYSKFKQL---FLIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQN 384
Query: 363 SNILVHCSDGWDRTAQITSLVQLSLDPYYRTIEGFMVLVEKDWLAFGHRFCERSGHL 419
N+L+ + D I+SLVQL +DP+ RT GF L++K+W+ GH F +R HL
Sbjct: 385 MNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHL 441
>CE23833 [R] KOG1090 Predicted dual-specificity phosphatase
Length = 1731
Score = 69.7 bits (169), Expect = 1e-11
Identities = 34/83 (40%), Positives = 52/83 (61%)
Query: 330 SMLNSDKSSSWLKYIKLLLSSTDTLVKSIVFNNSNILVHCSDGWDRTAQITSLVQLSLDP 389
S L S +S+W + + ++ ++++V + NS++ + G T ++SL QL DP
Sbjct: 1245 SFLESWNASNWPQCVSRMIELSNSIVALMNLYNSSVAICLEAGRSITTILSSLSQLLSDP 1304
Query: 390 YYRTIEGFMVLVEKDWLAFGHRF 412
YYRT +GF VLVEK+WLAFGH F
Sbjct: 1305 YYRTCDGFQVLVEKEWLAFGHYF 1327
Score = 57.0 bits (136), Expect = 8e-08
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 44/149 (29%)
Query: 480 TSPVFQQFLDCVHQLLIQYPTQFEFNERFLRRLVYHLYSCQYGTFIFDNEYERVTNNAFH 539
+SP F FLDCV+Q+ QYPT FEF+ ++ L YH + + TFI D E +R+ ++A
Sbjct: 1334 SSPSFICFLDCVYQISQQYPTAFEFSYFYISFLAYHSTAGYFRTFIDDCEEKRLQSDANE 1393
Query: 540 -------QTRSVWDY------------------------------------FRSRTH-EF 555
T +VW++ F + TH ++
Sbjct: 1394 FYLPDNLATINVWEFIKLRNRVSAAFYNELYEQIGDIVIPSSSIPQIHMWPFLAETHLKY 1453
Query: 556 SNPNYREPSDDEEDWILPDWEKVEWWWQL 584
+P EP+ E+ + PD+E+ E W +L
Sbjct: 1454 GSPYDIEPASHEQQLVDPDYEEEEDWSKL 1482
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,290,779
Number of Sequences: 60738
Number of extensions: 1827258
Number of successful extensions: 4383
Number of sequences better than 1.0e-05: 29
Number of HSP's better than 0.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 4229
Number of HSP's gapped (non-prelim): 70
length of query: 629
length of database: 30,389,216
effective HSP length: 113
effective length of query: 516
effective length of database: 23,525,822
effective search space: 12139324152
effective search space used: 12139324152
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)