ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1633 good U KOG1983 Intracellular trafficking, secretion, and vesicular transport Tomosyn and related SNARE-interacting proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1633 577239 574276 -988
(988 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBL106c [U] KOG1983 Tomosyn and related SNARE-interacting proteins 990 0.0
YPR032w [U] KOG1983 Tomosyn and related SNARE-interacting proteins 959 0.0
SPAC1F3.03 [U] KOG1983 Tomosyn and related SNARE-interacting pro... 242 2e-63
Hs20535595 [U] KOG1983 Tomosyn and related SNARE-interacting pro... 101 5e-21
7292792 [U] KOG1983 Tomosyn and related SNARE-interacting proteins 85 5e-16
Hs4758680 [U] KOG1983 Tomosyn and related SNARE-interacting prot... 73 2e-12
Hs22065300 [U] KOG1983 Tomosyn and related SNARE-interacting pro... 67 1e-10
Hs4758678 [U] KOG1983 Tomosyn and related SNARE-interacting prot... 64 9e-10
>YBL106c [U] KOG1983 Tomosyn and related SNARE-interacting proteins
Length = 1010
Score = 990 bits (2559), Expect = 0.0
Identities = 496/1008 (49%), Positives = 703/1008 (69%), Gaps = 33/1008 (3%)
Query: 3 KSKKLKTVSNAIKSVASKDASNGISSKMFELSEVSRYGMNGKVCTFAFDPVQSLLAIATD 62
KS+ LK VSNAIKS D SNGI+SK F+ ++ YG+NG++ FD QSLLA+AT
Sbjct: 4 KSRHLKNVSNAIKSARVHDVSNGINSKFFDTKKICTYGINGRITVTTFDYTQSLLAVATT 63
Query: 63 SGEIHVYGKQQVEVVFTLEVKA-IKEMRFIKGIYLIVVDAKDSLSVLSLHKKALLASFFP 121
+GEIHVYG++Q+EVVFTL+ + IK MRFIKGIYLI VD K ++ VLS+H K +L + F
Sbjct: 64 AGEIHVYGQKQIEVVFTLKNRPQIKHMRFIKGIYLIAVDEKSNIIVLSVHSKQILTTVFC 123
Query: 122 PGKITCIETDPSLNWVLIGLQSGATIVYDVDRDYLSPFKIENLQKSRFFKREPLSPVVSL 181
P ITC ETDP L+W+LIGL+SG+ ++YDVDR+ +S KIEN QKS F +E LSPV+S+
Sbjct: 124 PNSITCFETDPPLDWMLIGLESGSILIYDVDRNQMSKLKIENFQKSVFLPKERLSPVISI 183
Query: 182 QWNPRDIGTVLIAYDKVTVLYSFVENDVKQQFIHE--------------EGENVPKVLHS 227
QWNPRDIGT+LI+Y+ +TV+YSF++ VKQ F ++ E + PKV+ S
Sbjct: 184 QWNPRDIGTILISYEHITVIYSFIDYKVKQHFFYQLEPYAPGGDLSTNIEKKRTPKVIQS 243
Query: 228 VFHPNGLNIMTVHDGNCLVFWDSNTGQKIVSRFLLDE-----DPLITS---TVSTSIFKV 279
++HPN L+I+TVH+ N LVFWD N+G+ I +R + + +P + T + +IFKV
Sbjct: 244 LYHPNSLHILTVHEDNALVFWDVNSGKLIHARSIFETHVNFPNPALKDCSFTETPAIFKV 303
Query: 280 AWIQEKDENSTSLLFAGGSGDATTGDHSLTLINLGPTPIYTVTSYDKMATYYAQPVSQKI 339
+W+ +++ TSLL A + + +T+I+LG TP+Y+VTS+D M+ YYA+PV QK+
Sbjct: 304 SWLCQRNPEYTSLLIATKATENPCLPQEITMIDLGGTPMYSVTSFDAMSKYYAKPVQQKL 363
Query: 340 IPVPNDASIINFLPLANGNPYYAGNFAPMVILVLLDDGEIETLLYPSGSITYKASLFPQS 399
+ A +INFLPL +PY+ G +IL+LL+DGE+ETL+YP+GS + KAS+FP+S
Sbjct: 364 FSLIGKAPLINFLPLPKASPYFGGCHDTNLILLLLEDGELETLIYPAGSFSSKASIFPRS 423
Query: 400 ISWIRPAATTSYATSVPKKTWLGMMSATYNRDYILKGGYPAKKTLRVHDSRSALSTGHTN 459
++W+RP TT A SV K WLGMM+ + + LKGG PA + +R H++RSAL TGH+N
Sbjct: 424 LAWVRPTVTTCIAQSVQKNLWLGMMTIAQSESF-LKGGIPATRNIRRHETRSALLTGHSN 482
Query: 460 GSVRIWDASHGELDESSVFDVNVSHSLNTSQSVAVDHISYAAETAELAVSIESGDVVLYK 519
GSVRIWDASH E+ +++VF+VN + LN + ++A+ +IS+A+ET ELAVS E GDV+L+K
Sbjct: 483 GSVRIWDASHSEVTDNAVFEVNTAKVLNRATNLAIKNISFASETLELAVSSEVGDVILFK 542
Query: 520 FQVNQFFTS-QKDVALEMNFRRFSLNDKPHEILVDIRDRAPNNIREGFMPVTAVHARKGR 578
F+ N+F+ K AL++ F RFSL+D ILVD+ DR P N+++GF+P T +HA+KG
Sbjct: 543 FETNKFYGQLPKSDALQLKFSRFSLDDSK-TILVDVSDRGPTNVKQGFIPSTVIHAKKGA 601
Query: 579 VSSLCNSNVGFVAIAYEDGTIIVIDRRGPAMIYMDSISKISKVRSSYVSQFEFTIMEYGE 638
VS++ NSN+GFVA+ + +GT+I++DRRGPA+I+ ++I ISK SSYVS F +MEYG+
Sbjct: 602 VSAIMNSNIGFVAVGFIEGTLIILDRRGPAIIFNENIRVISKAGSSYVSTVHFCVMEYGD 661
Query: 639 DGYSSILLLCGTDAGEVILLKIIPDPSGRFTVQPYDALKATDDGPIVSLATFSKESGSSC 698
DG+SSIL+LCGTD GE++ KI+P +GRF V+ DA K + G I+ + +F+K++G SC
Sbjct: 662 DGFSSILMLCGTDIGELMTFKILPATNGRFEVKFTDATKTNNQGKILGINSFAKDTGYSC 721
Query: 699 RASIPRMQQLSKGLRVQAQIVISGRTDIRLITPGKSKDTHRIFKYPIAVSGLSIVPFLNA 758
A+I +MQ LSKG+ + + ISG DIRL++PGKSKDTH +FKYPIA SGLS +P ++
Sbjct: 722 SATISKMQGLSKGIAIPGFVTISGANDIRLVSPGKSKDTHALFKYPIATSGLSFIPIIDG 781
Query: 759 KNEHSIATVLVTVLINGEIKVLSLPELKEIKSFAPLANVHSKYVKESGVLVNGDIVYRVS 818
K E ++T+++ +LING+IKVL++PELKE+K+ + ++YV+ S +L N DIV R
Sbjct: 782 KGERKLSTIMIVLLINGDIKVLTVPELKEVKNLRCPVPLSAQYVENSSILENVDIVIRTG 841
Query: 819 KTEAFLLTVIKKXXXXXXXXXXXX----XXXLYNPNLRIKCRPYYNSLQWVRGSIYCKPE 874
K +A L++V+ + LYNP+L+I RP NSLQW RG+IYC P
Sbjct: 842 KFQASLISVLNESATGSNHTADISQHTPIDTLYNPDLKIGYRPQVNSLQWARGTIYCTPY 901
Query: 875 DLDHLLGE-GRPEQKYEEEKIAKGTISLSPEEKTHNTHELSANGRYQYQAPVRHSAKSGG 933
LD LLG RPE KYEE IA+G IS S + + ++Y PVR S +S G
Sbjct: 902 QLDELLGGIERPESKYEESAIARGCISSSSSNAARKLPPGTKD--HRYARPVRSSGRSNG 959
Query: 934 YGPLRSISRAMQNGMDSIEDTFNDYATAANETMNDATDQIGKDLIKGA 981
YG L+S+SRA++ +D++E T NDYAT +TMNDA ++ G+D++K A
Sbjct: 960 YGVLKSVSRAIETRLDTVETTINDYATTMGQTMNDAMEETGRDMMKSA 1007
>YPR032w [U] KOG1983 Tomosyn and related SNARE-interacting proteins
Length = 1033
Score = 959 bits (2479), Expect = 0.0
Identities = 509/1012 (50%), Positives = 698/1012 (68%), Gaps = 46/1012 (4%)
Query: 2 FKSK--KLKTVSNAIKSVASKDA--SNGISSKMFELSEVSRYGMNGKVCTFAFDPVQSLL 57
FKSK K T+S KS +S S+ +K+F L+E ++YGM+ K AFD Q+LL
Sbjct: 33 FKSKNSKTSTISKDAKSSSSLKIPISSNNKNKIFSLAETNKYGMSSKPIAAAFDFTQNLL 92
Query: 58 AIATDSGEIHVYGKQQVEVVFTLEVK-AIKEMRFIKGIYLIVVDAKDSLSVLSLHKKALL 116
AIAT +GE+H+YG+QQVEVV LE + AIKEMRF+KGIYL+V++AKD++ VLSL+ + +L
Sbjct: 93 AIATVTGEVHIYGQQQVEVVIKLEDRSAIKEMRFVKGIYLVVINAKDTVYVLSLYSQKVL 152
Query: 117 ASFFPPGKITCIETDPSLNWVLIGLQSGATIVYDVDRDYLSPFKIENLQKSRFFKREPLS 176
+ F PGKIT I+TD SL+W+LIGLQ+G+ IVYD+DRD LS FK++NLQKS FF LS
Sbjct: 153 TTVFVPGKITSIDTDASLDWMLIGLQNGSMIVYDIDRDQLSSFKLDNLQKSSFFPAARLS 212
Query: 177 PVVSLQWNPRDIGTVLIAYDKVTVLYSFVENDVKQQFIHE--------------EGENVP 222
P+VS+QWNPRDIGTVLI+Y+ VT+ YS VEN++KQ FI+E + P
Sbjct: 213 PIVSIQWNPRDIGTVLISYEYVTLTYSLVENEIKQSFIYELPPFAPGGDFSEKTNEKRTP 272
Query: 223 KVLHSVFHPNGLNIMTVHDGNCLVFWDSNTGQKIVSRFLLDEDPLI--------TSTVST 274
KV+ S++HPN L+I+T+H+ N LVFWD+N+G I++R + + + + +ST +
Sbjct: 273 KVIQSLYHPNSLHIITIHEDNSLVFWDANSGHMIMARTVFETEINVPQPDYIRDSSTNAA 332
Query: 275 SIFKVAWIQEKDENSTSLLFAGGSGDATTGDH-SLTLINLGPTPIYTVTSYDKMATYYAQ 333
I KV W+ E + TSLL + S + GD+ SLT+I+LG TP Y++TSY+ M YYA
Sbjct: 333 KISKVYWMCENNPEYTSLLISHKS--ISRGDNQSLTMIDLGYTPRYSITSYEGMKNYYAN 390
Query: 334 PVSQKIIPVPNDASIINFLPLANGNPYYAGNFAPMVILVLLDDGEIETLLYPSGSITYKA 393
P KI P+P + I+N LP+ +PY+AG P +IL++L +GEIET+LYPSG T KA
Sbjct: 391 PKQMKIFPLPTNVPIVNILPIPRQSPYFAGCHNPGLILLILGNGEIETMLYPSGIFTDKA 450
Query: 394 SLFPQSISWIRPAATTSYATSVPKKTWLGMMSATYNRDYILKGGYPAKKTLRVHDSRSAL 453
SLFPQ++SW+RP ATTS A SVP K WLG +SA N+DY+LKGG K+ + +A
Sbjct: 451 SLFPQNLSWLRPLATTSMAASVPNKLWLGALSAAQNKDYLLKGGVRTKRQKLPAEYGTAF 510
Query: 454 STGHTNGSVRIWDASHGELDESSVFDVNVSHSLNTSQSVAVDHISYAAETAELAVSIESG 513
TGH+NGSVRI+DASHG++ +++ F+VN+S +LN ++ +AVD IS+AAET ELAVSIE+G
Sbjct: 511 ITGHSNGSVRIYDASHGDIQDNASFEVNLSRTLNKAKELAVDKISFAAETLELAVSIETG 570
Query: 514 DVVLYKFQVNQFFTSQ---KDVALEMNFRRFSLNDKPHEILVDIRDRAPNNIREGFMPVT 570
DVVL+K++VNQF++ + + LEMNFRRFSLN+ + +LVD+RDRAP +R+GFMP T
Sbjct: 571 DVVLFKYEVNQFYSVENRPESGDLEMNFRRFSLNNT-NGVLVDVRDRAPTGVRQGFMPST 629
Query: 571 AVHARKGRVSSLCNSNVGFVAIAYEDGTIIVIDRRGPAMIYMDSISKISKVRSSYVSQFE 630
AVHA KG+ S++ NSN+GFV IAY G++++IDRRGPA+IYM++I +IS +S+ V+ E
Sbjct: 630 AVHANKGKTSAINNSNIGFVGIAYAAGSLMLIDRRGPAIIYMENIREISGAQSACVTCIE 689
Query: 631 FTIMEYGEDGYSSILLLCGTDAGEVILLKIIPDPSGRFTVQPYDALKATDDGPIVSLATF 690
F IMEYG+DGYSSIL++CGTD GEVI KI+P G+F VQ D T GPI + F
Sbjct: 690 FVIMEYGDDGYSSILMVCGTDMGEVITYKILPASGGKFDVQLMDITNVTSKGPIHKIDAF 749
Query: 691 SKESGSSCRASIPRMQQLSKGLRVQAQIVISGRTDIRLITPGKSKDTHRIFKYPIAVSGL 750
SKE+ SSC A+IP+MQ LSKGL + ++I+G DIRLIT GKSK TH+ FKYP+A +GL
Sbjct: 750 SKETKSSCLATIPKMQNLSKGLCIPGIVLITGFDDIRLITLGKSKSTHKGFKYPLAATGL 809
Query: 751 SIVPFLNAKNEHSIATVLVTVLINGEIKVLSLPELKEIKSFAPLANVHSKYVKESGVLVN 810
S + + N+ TV++T+ ING ++V ++P+ KE S + +KY+ ES VL N
Sbjct: 810 SYISTVEKNNDRKNLTVIITLEINGHLRVFTIPDFKEQMSEHIPFPIAAKYITESSVLRN 869
Query: 811 GDIVYRVSKTEAFLLTVIKKXXXXXXXXXXXXXXXLYNPNLRIKCRPYYNSLQWVRGSIY 870
GDI RVS+ +A L + +K+ LY +RI RP NSLQW RG++Y
Sbjct: 870 GDIAIRVSEFQASLFSTVKE-----QDTLAPVSDTLYINGIRIPYRPQVNSLQWARGTVY 924
Query: 871 CKPEDLDHLL-GEGRPEQKYEEEKIAKGTISLSPEEKTHNTHELSANGRYQYQAPVRHSA 929
C P L+ LL G RP KY+E IA+G+ S + + H +QY P R
Sbjct: 925 CTPAQLNELLGGVNRPASKYKESIIAEGSFSERSSDDNNANHP-----EHQYTKPTR-KG 978
Query: 930 KSGGYGPLRSISRAMQNGMDSIEDTFNDYATAANETMNDATDQIGKDLIKGA 981
++ YG LR++SRA++ D++ED FNDYATA ETMN+A +Q GKD++KGA
Sbjct: 979 RNSSYGVLRNVSRAVETRWDAVEDRFNDYATAMGETMNEAVEQTGKDVMKGA 1030
>SPAC1F3.03 [U] KOG1983 Tomosyn and related SNARE-interacting proteins
Length = 1004
Score = 242 bits (617), Expect = 2e-63
Identities = 248/1041 (23%), Positives = 448/1041 (42%), Gaps = 104/1041 (9%)
Query: 3 KSKKLKTVSNAIKSVASKDASNGISSKMFELSEVSRYGMNGKVCTFAFDPVQSLLAIATD 62
K K++ + SN +K+ S +AS + +++R+G + + D Q LLAI +
Sbjct: 10 KGKEILSKSN-LKTHTSSNAS-------LSIDDLNRFGFSLNPVLWCLDHQQGLLAIVSS 61
Query: 63 SGEIHVYGKQQVEVVFTLEVKAIKEMRFIKGIYLIVVDAKDSLSVLSLHKKALL----AS 118
+ I++YGKQ V+ V + I + YLIV+D+++++ L K L A+
Sbjct: 62 TNRIYIYGKQHVQSVIVPDCSTIVHIALCAA-YLIVIDSRNTVLSYPLMKHRDLSKPAAT 120
Query: 119 FFPPGKITCIETDPSLNWVLIGLQSGATIVYDVDRDYLSPFKIENLQKSRF-------FK 171
+F K+TC TDP+++WV G+ G+ + +DV R L FK+ NL R +
Sbjct: 121 YFLKQKVTCTVTDPTIDWVFFGMSDGSVVPWDVTRHCLGKFKVPNLYVPRHEEWRMMGYS 180
Query: 172 REP----LSPVVSLQWNPRDIGTVLIAYDKVTVLYSFVENDVKQQFIHEEGENVPKVLHS 227
P LSPVVS+Q +P+D+G +LIAY VLYS ++V + + E E P +
Sbjct: 181 YAPVPGKLSPVVSVQIHPKDLGVILIAYPDGVVLYSIRTDEVIRFY---ELEYAPGSTAA 237
Query: 228 VFHPN---------------GLNIMTVHDGNCLVFWDSNTGQKIVSRFLLDED-----PL 267
V P+ G + ++ + + FWD + + R +D + P+
Sbjct: 238 VLSPHNYRRPIVKGIEWSPWGDHFVSYYTDSTFAFWDVDQEYPVQVRNFVDSNIHTYTPM 297
Query: 268 ITSTVSTS---IFKVAWIQEKDENSTSLLFAGGSGDATTGDHSLTLINLGPTPIYTVTSY 324
+ T I + W +D + +L GG ++L + P
Sbjct: 298 QRNPPKTELEPIRSMRWCCCEDPTVSFILMLGGL-PKEAPVKGISLFSYRNLP--AKKDV 354
Query: 325 DKMATYYAQPVSQKIIPVPNDASIINFLPLANGNPYYAGNFAPMVILVLLDDGEIETLLY 384
+ A ++A P SQ+ P + + + L + + +P+Y G+ P +L+L +D + L
Sbjct: 355 ETFAEFFANPNSQRFFPFIDIPPVRDMLVIPSSSPHYNGSHNPKNLLLLSEDNSLSLLDI 414
Query: 385 PSGSITYKASLFPQSISWIRPAATTSYATSVPKKTWLGMM-SATYNRDY-ILKGGYPAKK 442
+G+I+ + P S+ ++ +V KK W + + + N Y L GG P+
Sbjct: 415 STGNISNMSLSIPPSLCFLASDFRVIAFQTVTKKVWNQIEDTISVNSHYSCLFGGSPSPG 474
Query: 443 TLRVHDSRSALSTGHTNGSVRIWDASHGELDESSVFDVNVSHSL--NTSQSVAVDHISYA 500
L+ D R+ L T T S+ IWD S G ++ S +++ S + + + S + S++
Sbjct: 475 YLKKLDERNLLITS-TGLSLSIWDISQGFMNPSLCVNLDFSSVMRKHLTPSAFITTASFS 533
Query: 501 AETAELAVSIESGDVVLYKFQVNQFFTSQKDVALEMNFRRFSLNDKPHEILVDIRDRAPN 560
E + + G V++ K R+ + P ++ I
Sbjct: 534 TYNPEFSCADSFGRVIVCK-------------------RKNHKENLPAQLANGIYRLDDT 574
Query: 561 NIREGFMPVT-AVHARKGRVSSLCNSNVGFVAIAYEDGTIIVIDRRGPAMIYMDSISKI- 618
+ EG + + ++GRV+ SN+GFV I Y+DG I +ID RGP ++ SIS++
Sbjct: 575 LVLEGTLHAQYYIDLKRGRVTLNQMSNIGFVCIGYQDGGITIIDMRGPHILCNTSISELG 634
Query: 619 ----SKVRSSYVSQFEFTIMEYGEDGYSSILLLCGTDAGEVILLKIIPDPSGRFTVQPYD 674
K +++ EF +M + SSI ++ GT G +L +I P SGRF+ ++
Sbjct: 635 LERRGKPDPDFLTSAEFVVMN-PKGSPSSIYVVTGTYRGMTLLFRIDPSSSGRFSAY-FE 692
Query: 675 ALKATDDGPIVSLATFSKESGSSCRASIPRMQQLSKGLRVQAQIVISGRTDIRLITPGKS 734
+ + D I + + +++ G A+ +Q + L + +V G + I + +
Sbjct: 693 SSRQLDIKNIYKICSLTQD-GQIATATGSSLQSVGYPLPQEVFLVYIGDSGISVFNKINN 751
Query: 735 KDTHRIFKYPIAVSGLSIVPFLNAKNEHSIATVLVTVLINGEIKV--LSLPELKEIKSFA 792
+ + ++ P+ + L+ ++H + V V N ++ V SLP L+E +
Sbjct: 752 QVGNLDWRKPVCCRAALV---LSTVSKHMGSVVCV----NSDLSVNWYSLPNLREERKMQ 804
Query: 793 PLANVHSKYVKESGVLVNGDIVYRVSKTEAFLLTVIKKXXXXXXXXXXXXXXXLYNPNLR 852
++ +KE +L NGD ++ + + +
Sbjct: 805 LPLDIDKNRLKEGDILGNGDYIFPTLGAHELAFGCV--LGSGRTLANLAPMMLITHNASH 862
Query: 853 IKCRPYYNSLQWVRGSIYCKPEDLDHLL-GEGRPEQK---YEEEKIAKGTISLSPEEKTH 908
+ RP + W+ G E+LD LL GE R E K E K+ + S ++
Sbjct: 863 VPPRPSKSLWNWLLGEQSTSAEELDILLGGENRAESKVHTLETPKVISARPAESVKQPLT 922
Query: 909 NTHELSANGRYQYQAPVRHSAKSGGYGPLRSISRAMQNGMDSIEDTFNDYATAANETMND 968
+++ Y P R + G + + N + IE+T +D + E N+
Sbjct: 923 PVPSMTSQSAQSYIPPRRQQQQKGFFAQINDHLAQRGNMLGGIENTMDDLEEMSAEWANE 982
Query: 969 ATDQIG---KDLIKGAFNSKI 986
D + KDLI S I
Sbjct: 983 IKDSLAGTKKDLILSGLKSYI 1003
>Hs20535595 [U] KOG1983 Tomosyn and related SNARE-interacting proteins
Length = 1186
Score = 101 bits (252), Expect = 5e-21
Identities = 127/551 (23%), Positives = 228/551 (41%), Gaps = 63/551 (11%)
Query: 17 VASKDASNGISSKMFELSEVSRYGMNGKVCTFAFDPVQSLLAIATDSGEIHVYGKQQVEV 76
V ++ ++S+ F++ + R+G + AFDPVQ +LAI T +G I + G+ V+
Sbjct: 45 VLREEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDC 104
Query: 77 VFTLEV-KAIKEMRF-IKGIYLIVVDAKDSLSVLSLHKK--ALLASF-FPPGKITCIETD 131
E A+ +++F I L+ + D+L + +L +K A+L S F +IT
Sbjct: 105 YCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLP 164
Query: 132 PSLNWVLIGLQSGATIVYDVDRDYLSPFKIENLQKSRFFKREPLSPVVSLQWNPRDIGTV 191
W+ +G + G T + +++ LS + I + + PVV L +PRD G +
Sbjct: 165 FQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKL 224
Query: 192 LIAYDKVTVLYSFVENDVKQQFIHEEGENVPKVLHSV-FHPNGLNIMTVHDGNCLVFWDS 250
LI Y+ TV++ +++ + ++ + + +HS+ +H G M H L W+
Sbjct: 225 LIGYENGTVVFWDLKSKRAELRVYYD-----EAIHSIDWHHEGKQFMCSHSDGSLTLWNL 279
Query: 251 NTGQKIVSRFLLDEDPLITSTVSTSIFKVAWIQEK--DENSTSLLFAGG-SGDATTGDHS 307
+ + + S S + ++ K + ++F+GG S D S
Sbjct: 280 KSPSRPFQTTIPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIFSGGLSYDKACRRPS 339
Query: 308 LTLINLGPTPIYTVTSYDKMATYYAQPVSQKIIPVPNDASIINFLPLANGNPYYAGNFAP 367
LT+++ + I + D I+ FL L PY P
Sbjct: 340 LTIMH-----------------------GKAITVLEMDHPIVEFLTLCE-TPYPNEFQEP 375
Query: 368 MVILVLLDDGEIETLLYPSGSITYKASLFPQSISWIRPAATTSYATSVPKKTWLGMMS-- 425
++VLL+ I L S ++ + +P I P T+Y P L + S
Sbjct: 376 YAVVVLLEKDLIVVDLTQSNFPIFE-NPYPMDIH-ESPVTCTAYFADCPPDLILVLYSIG 433
Query: 426 ------ATYNRDYILKGGYPAKKTLRVHDSRSALSTGHTNGSVRIWDASH------GELD 473
N+++ + GG L + TGH +GS++ WDAS +L
Sbjct: 434 VKHKKQGYSNKEWPISGG---AWNLGAQTYPEIIITGHADGSIKFWDASAITLQMLYKLK 490
Query: 474 ESSVFD-VNVSHSLNTSQSV-----AVDHISYAAETAELAVSIESGDVVLYKFQVNQFFT 527
S VF+ V T + V A+ I + E+ VS S V++YKF ++ T
Sbjct: 491 TSKVFEKQKVGEGKQTCEIVEEDPFAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITT 550
Query: 528 SQKDVALEMNF 538
+ + + +
Sbjct: 551 EIVSLEVRLQY 561
>7292792 [U] KOG1983 Tomosyn and related SNARE-interacting proteins
Length = 960
Score = 85.1 bits (209), Expect = 5e-16
Identities = 117/523 (22%), Positives = 212/523 (40%), Gaps = 68/523 (13%)
Query: 31 FELSEVSRYGMNGKVCTFAFDPVQSLLAIATDSGEIHVYGKQQVEVVFTLEVKAIKEMRF 90
F L + R+G +FAFDPVQ LLAI SG I + G+ V+ E ++ + F
Sbjct: 37 FTLKKTFRHGFPYSPTSFAFDPVQKLLAIGDKSGYIRILGRPGVDAHAKHEGESECAVLF 96
Query: 91 IKGIY----LIVVDAKDSLSVLSLHKKA---LLASFFPPGKITCIETDPSLNWVLIGLQS 143
+ + L+ V A D++ + S+ +K + + F ++TCI W+ +G +
Sbjct: 97 AQFLVNEGALVTVTADDTIHLWSIRQKTPRIVQSLKFQRERVTCIHLPVGSKWLYVGTEK 156
Query: 144 GATIVYDVDRDYLSPFKIENLQKSRFFKREPLSPVVSLQWNPRDIGTVLIAYD-KVTVLY 202
G V +D LS + I + + V++L NP D +LIA++ + VL+
Sbjct: 157 GNIHVVHIDTFALSGYIINWNKAIEVVRTSHPGAVIALCDNPLDANKLLIAFECGLLVLW 216
Query: 203 SFVENDVKQQFIHEEGENVPKVLHSVFHPNGLNIMTVHDGNCLVFWDSNTGQKIVSRFL- 261
D+K + + V +H G ++ H + W + K S+
Sbjct: 217 -----DLKAKCAELRWQAAEAVKSLAWHYEGKYFVSSHTDGSICSWPTKPQAKPQSQVCP 271
Query: 262 ---LDEDPLITSTVSTSIFKVAWIQEKDENSTSLLFAGGSGDATTGDHSLTLINLGPTPI 318
+++D + I+KV ++ T +F+GG + + +G
Sbjct: 272 HAKINKDG--NAEKCKPIYKVD-LKSSATGETFTIFSGGMPSEKGSKSNCITVMVG---- 324
Query: 319 YTVTSYDKMATYYAQPVSQKIIPVPNDASIINFLPLANGNPYYAGNFAPMVILVLLDDGE 378
K T + + ++ +F+ L NP+ P I VLL
Sbjct: 325 -------KATTV-----------LEMEHAVCDFITLCE-NPWPCETQEPYAIAVLLQYDL 365
Query: 379 IETLLYPSGSITYKASLFPQSISWIRPAATTSYATSVPK----------KTWLGMMSATY 428
+ L G ++ S +P + P +Y T P +T S
Sbjct: 366 VLIDLLTPGFPCFE-SPYPMDLH-ESPVTCCTYLTDCPSDLVPAFYSVGRTTTSKKSCFS 423
Query: 429 NRDYILKGGYPAKKTLRVHDSRSALSTGHTNGSVRIWDASHG------ELDESSVFD--- 479
R++ + GG + + + + TGH +GS++ WD+ G +L + +F+
Sbjct: 424 EREWPISGGEWSPASCSYSE---IVITGHQDGSLKFWDSGAGTLQILYKLKTAKMFEKPR 480
Query: 480 VNVSHSLNTSQS-VAVDHISYAAETAELAVSIESGDVVLYKFQ 521
+V+HS S + +AV I +E+ L V+ G V+L+KF+
Sbjct: 481 SHVAHSHPESDNPLAVHLIFLCSESRRLCVAGAMGQVMLFKFR 523
>Hs4758680 [U] KOG1983 Tomosyn and related SNARE-interacting proteins
Length = 1015
Score = 72.8 bits (177), Expect = 2e-12
Identities = 107/480 (22%), Positives = 191/480 (39%), Gaps = 87/480 (18%)
Query: 30 MFELSEVSRYGMNGKVCTFAFDPVQSLLAIATDSGEIHVYGKQQVEVV-FTLEVKAIKEM 88
+F+ ++ +G + + P +LAI T SG I +YG VE + E A+ ++
Sbjct: 20 LFQFNKTVEHGFPHQPSALGYSPSLHILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQI 79
Query: 89 RFIKG-IYLIVVDAKDSLSVLSLHKKALLASFF---------PPG------KITCIETDP 132
+ G L+ + +SL + SL K + PPG +IT +
Sbjct: 80 HLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHS 139
Query: 133 SLNWVLIGLQSGATIVYDV-------DRDYLSPFKIENLQKSRFFKREPLSPVVSLQWNP 185
S + +G +SG V + DR S ++ L + +R V +LQ +P
Sbjct: 140 SCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRV-FEMVEALQEHP 198
Query: 186 RDIGTVLIAYDK-VTVLYSFVENDVKQQFIHEEG-ENVPKVLHSVFHPNGLNIMTVHDGN 243
RD +LI Y + + V++ + V F+ + EN+ + +G +++ H
Sbjct: 199 RDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENI------WWQRDGRLLVSCHSDG 252
Query: 244 CLVFW--DSNTGQKIVSRFLLDEDPLITSTVSTSIFKVAWIQEKDENSTSLLFAGGSGDA 301
W S Q R L+ P ++ ++ W+ + + +F GG A
Sbjct: 253 SYCQWPVSSEAQQPEPLRSLVPYGPFPCKAIT----RILWLTTR-QGLPFTIFQGGMPRA 307
Query: 302 TTGD-HSLTLINLGPTPIYTVTSYDKMATYYAQPVSQKIIPVPNDASIINFLPLANGNPY 360
+ GD H +++I+ G + TS +I F L +P
Sbjct: 308 SYGDRHCISVIHDGQQTAFDFTS-----------------------RVIGFTVLTEADP- 343
Query: 361 YAGNFAPMVILVLLDDGEI-----ETLLYPSGSITYKASLFPQSISWIRPAATTSYATSV 415
A F LV+L + E+ +T +P + Y ASL +I+ + + +++
Sbjct: 344 -AATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAIT------CSHHVSNI 396
Query: 416 PKKTWLGMMSATYNR-------DYILKGGYPAKKTLRVHDSRSALSTGHTNGSVRIWDAS 468
P K W +++A + ++ + GG R L TGH +G+VR WDAS
Sbjct: 397 PLKLWERIIAAGSRQNAHFSTMEWPIDGG---TSLTPAPPQRDLLLTGHEDGTVRFWDAS 453
>Hs22065300 [U] KOG1983 Tomosyn and related SNARE-interacting proteins
Length = 1062
Score = 67.4 bits (163), Expect = 1e-10
Identities = 103/528 (19%), Positives = 207/528 (38%), Gaps = 107/528 (20%)
Query: 26 ISSKMFELSEVSRYGMNGKVCTFAFDPVQSLLAIATDSGEIHVYGKQQVEVV-FTLEVKA 84
+ ++F ++ +G + AFDP ++AI T SG + +YG VE +
Sbjct: 18 LKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPGVEFTGLHRDAAT 77
Query: 85 IKEMRFIKGIYLIVVDAKDSLSVL--------SLHKKALLASFFP--PG----------- 123
+ +M F+ G ++ DS L H + L+ P PG
Sbjct: 78 VTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLPSRPGFDGASAPLSLT 137
Query: 124 KITCIETDPSLNWVLIGLQSGATIVYDV------DRDYLSPFKIENLQKSRFFKREPLSP 177
++T + + + +G + + DV + L+P ++ + + L P
Sbjct: 138 RVTVVLLVAASDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKALGP 197
Query: 178 VVSLQWNPRDIGTVLIAYDK-VTVLYSFVENDVKQQFIHEEGENVPKVLHSVFHPNGLNI 236
V SLQ + RD +LI Y + + V+++ V F+ + ++ + + +
Sbjct: 198 VESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFLGNQ-----QLESLCWGRDSSTV 252
Query: 237 MTVHDGNCLVFWDSNTGQKIVSRFLLDEDPLITSTVSTS---------IFKVAWIQEKDE 287
++ H W + G P + TV+T+ I K+ W + +
Sbjct: 253 VSSHSDGSYAVWSVDAGSF----------PTLQPTVATTPYGPFPCKAINKILW-RNCES 301
Query: 288 NSTSLLFAGGSGDATTGD-HSLTLINLGPTPIYTVTSYDKMATYYAQPVSQKIIPVPNDA 346
++F+GG A+ GD H ++++ ++ ++ + +
Sbjct: 302 GGHFIIFSGGMPRASYGDRHCVSVLR-----------------------AETLVTLDFTS 338
Query: 347 SIINFLPLANGNPYYAGNFAPMVILVLLDDG----EIETLLYPSGSITYKASLFPQSISW 402
II+F + + P + P + VLL++ +++T +P+ Y A L +I+
Sbjct: 339 RIIDFFTVHSTRPEDEFD-DPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPLHSSAIT- 396
Query: 403 IRPAATTSYATSVPKKTWLGMMSATYNRD---------YILKGGYPAKKTLRVHDSRSAL 453
+++ SVP K W ++SA + + + GG + + R L
Sbjct: 397 -----CSAHVASVPAKLWARIVSAGEQQSPQPVSSALSWPITGG---RNLAQEPSQRGLL 448
Query: 454 STGHTNGSVRIWDASH------GELDESSVFDVNVSHSLNTSQSVAVD 495
TGH +G+VR WDAS +L + +F + H+ + +Q+ D
Sbjct: 449 LTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAAEDD 496
>Hs4758678 [U] KOG1983 Tomosyn and related SNARE-interacting proteins
Length = 1057
Score = 64.3 bits (155), Expect = 9e-10
Identities = 108/530 (20%), Positives = 209/530 (39%), Gaps = 110/530 (20%)
Query: 26 ISSKMFELSEVSRYGMNGKVCTFAFDPVQSLLAIATDSGEIHVYGKQQVEVV-FTLEVKA 84
+ ++F ++ +G + AFDP ++AI T SG + +YG VE +
Sbjct: 18 LKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPGVEFTGLHRDAAT 77
Query: 85 IKEMRFIKGIYLIVVDAKDSLSVL--------SLHKKALLASFFP--PG----------- 123
+ +M F+ G ++ DS L H + L+ P PG
Sbjct: 78 VTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLPSRPGFDGASAPLSLT 137
Query: 124 KITCIETDPSLNWVLIGLQSGATIVYDVDRDYLSPFKIENLQKSRFFKREP--------L 175
++T + + + +G + G++ V+ +D L+ + + L + P L
Sbjct: 138 RVTVVLLVAAGDIAALGTE-GSSSVFFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKDL 196
Query: 176 SPVVSLQWNPRDIGTVLIAYDKVTVLYSFVENDVKQQFIHEEGENVPKVLHSV-FHPNGL 234
PV SLQ + +D +LI Y + ++ + N Q H N + L S+ + +
Sbjct: 197 GPVESLQGHLQDPTKILIGYSRGLLV---IRNQASQCVDHIFLGN--QQLESLCWGRDSS 251
Query: 235 NIMTVHDGNCLVFWDSNTGQKIVSRFLLDEDPLITSTVSTS---------IFKVAWIQEK 285
+++ H W + G P + TV+T+ I K+ W +
Sbjct: 252 TVVSSHSDGSYAVWSVDAGSF----------PTLQPTVATTPYGPFPCKAINKILW-RNC 300
Query: 286 DENSTSLLFAGGSGDATTGD-HSLTLINLGPTPIYTVTSYDKMATYYAQPVSQKIIPVPN 344
+ ++F+GG A+ GD H ++++ ++ ++ +
Sbjct: 301 ESGGHFIIFSGGMPRASYGDRHCVSVLR-----------------------AETLVTLDF 337
Query: 345 DASIINFLPLANGNPYYAGNFAPMVILVLLDDG----EIETLLYPSGSITYKASLFPQSI 400
II+F + + P + P + VLL++ +++T +P+ Y A L +I
Sbjct: 338 HFRIIDFFTVHSTRPEDEFD-DPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPLHSSAI 396
Query: 401 SWIRPAATTSYATSVPKKTWLGMMSATYNRD---------YILKGGYPAKKTLRVHDSRS 451
+ +++ SVP K W ++SA + + + GG + + R
Sbjct: 397 T------CSAHVASVPAKLWARIVSAGEQQSPQPVSSALSWPITGG---RNLAQEPSQRG 447
Query: 452 ALSTGHTNGSVRIWDASH------GELDESSVFDVNVSHSLNTSQSVAVD 495
L TGH +G+VR WDAS +L + +F + HS + +Q+ D
Sbjct: 448 LLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHSDSLAQAAEDD 497
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.134 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,010,555
Number of Sequences: 60738
Number of extensions: 2517391
Number of successful extensions: 6681
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 6637
Number of HSP's gapped (non-prelim): 18
length of query: 988
length of database: 30,389,216
effective HSP length: 116
effective length of query: 872
effective length of database: 23,343,608
effective search space: 20355626176
effective search space used: 20355626176
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)