ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1670 good K KOG1318 Transcription Helix loop helix transcription factor EB
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1670 589223 587748 -492
(492 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBL103c [K] KOG1318 Helix loop helix transcription factor EB 198 2e-50
Hs6912702 [K] KOG1318 Helix loop helix transcription factor EB 61 3e-09
Hs8659574 [K] KOG1318 Helix loop helix transcription factor EB 57 6e-08
Hs4557755 [K] KOG1318 Helix loop helix transcription factor EB 57 6e-08
SPAC3F10.12c [K] KOG1318 Helix loop helix transcription factor EB 56 1e-07
CE28499 [K] KOG1318 Helix loop helix transcription factor EB 55 2e-07
CE16417 [K] KOG2483 Upstream transcription factor 2/L-myc-2 protein 55 2e-07
CE14416 [K] KOG1318 Helix loop helix transcription factor EB 55 2e-07
Hs22060220 [K] KOG1318 Helix loop helix transcription factor EB 53 1e-06
>YBL103c [K] KOG1318 Helix loop helix transcription factor EB
Length = 486
Score = 198 bits (503), Expect = 2e-50
Identities = 159/443 (35%), Positives = 209/443 (46%), Gaps = 76/443 (17%)
Query: 70 INELPDSQSSFTNANVHNNIHLPQSRQQSITGQQIETGTVATSFMDEYLSPASRGESDRN 129
I E +SQSS+ + + Q SI+ I G + +S+ Y SP R +
Sbjct: 95 IYEEAESQSSYLDDMFRTSQGGRPVTQNSISS--IGQGPLRSSYSMAYDSPVDRAMNTPL 152
Query: 130 QKQDFDHINLDETTKNLFDEPMFREHLQGSQATDDLVSNFTDDFVSSLGSSIHSDLMTP- 188
Q+Q E K +H TDD + N TDD SSL SSI+SD+MTP
Sbjct: 153 QQQ--------EGLKAELPHDFLFQH-----GTDDTMYNLTDDLSSSLSSSINSDMMTPN 199
Query: 189 --VSSYQPQPMNSFDXXXXXXXXXXXXXXXXXYRGASQLSSSLRSNRGSQQFPT------ 240
SS+ P + +R S LSSS R GS P
Sbjct: 200 TYSSSFSYNPQSLGPASVSSTYSPKVRSPSSSFRAGSFLSSSFR--HGSINTPRTRHTSI 257
Query: 241 SSSLT------STPKDMNSSALTQDEKIRRRREFHNAVERRRRELIKAKIKELGTLVPPT 294
SS++T S PK + LT DEK+RR+REFHNAVERRRRELIK KIKELG LVPP+
Sbjct: 258 SSNMTENIGPGSVPKILGG--LTSDEKLRRKREFHNAVERRRRELIKQKIKELGQLVPPS 315
Query: 295 LLHFDDFGKKVKPNKGTILKRTIEYMDCLKQVLEIQDAKKEELRKKIAELERKKSDLTNS 354
LL++DD GK++KPNKG IL RT+EY+ L ++LEIQ KK+ L KI ELE KKS +
Sbjct: 316 LLNYDDLGKQIKPNKGIILDRTVEYLQYLAEILEIQARKKKALLAKIKELEEKKSSVAAL 375
Query: 355 SLLQSGAYPKTSQNYQHISKSESPITHHISSEXXXXXXXXXXXXXXXXXXXXXXXXXXXX 414
S + + + QN + SE I S
Sbjct: 376 SPFTNNHHASSGQN--NSENSEERIIDIRS------------------------------ 403
Query: 415 XAHINNEYINDDEQYPE-RIIDSRTYPMLVKETNAGA------NAIHDDLQQFLSGTLME 467
+ N +N+ E + Y + +AG IH++L++FLSG L+E
Sbjct: 404 ---VPNALMNEQNSKAELHNWEPPLYDSVGNHNHAGTMESHPHTNIHEELKEFLSGDLIE 460
Query: 468 NEDNSKLMFSGRAENPVDLLLDF 490
EDN+KLMF NP D LL+F
Sbjct: 461 AEDNAKLMFGDDNSNPADYLLEF 483
>Hs6912702 [K] KOG1318 Helix loop helix transcription factor EB
Length = 347
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/138 (32%), Positives = 71/138 (50%), Gaps = 22/138 (15%)
Query: 220 RGASQLSSSLRSNRGSQQFPTSSSLTSTPKDMNSSALTQDEKIRRRREFHNAVERRRREL 279
+G S ++ L S P +T T ++ AL ++ R++++ HN +ERRRR
Sbjct: 102 QGISPINMGLTSASCPSSLPMKREITET----DTRALAKE---RQKKDNHNLIERRRRYN 154
Query: 280 IKAKIKELGTLVPPTLLHFDDFGKKVKPNKGTILKRTIEYMDCLKQVLEIQDAKKEELRK 339
I +IKELGTL+P + ++ NKGTILK ++EY+ L +KE+ R
Sbjct: 155 INYRIKELGTLIPKS------NDPDMRWNKGTILKASVEYIKWL---------QKEQQRA 199
Query: 340 KIAELERKKSDLTNSSLL 357
+ E +KK + N LL
Sbjct: 200 RELEHRQKKLEQANRRLL 217
>Hs8659574 [K] KOG1318 Helix loop helix transcription factor EB
Length = 575
Score = 57.0 bits (136), Expect = 6e-08
Identities = 35/96 (36%), Positives = 55/96 (56%), Gaps = 15/96 (15%)
Query: 261 KIRRRREFHNAVERRRRELIKAKIKELGTLVPPTLLHFDDFGKKVKPNKGTILKRTIEYM 320
K R++++ HN +ERRRR I +IKELGTL+P + +++ NKGTILK +++Y
Sbjct: 343 KERQKKDNHNLIERRRRFNINDRIKELGTLIPKS------SDPEMRWNKGTILKASVDY- 395
Query: 321 DCLKQVLEIQDAKKEELRKKIAELERKKSDLTNSSL 356
I+ +KE+ R K E ++ + N SL
Sbjct: 396 --------IRKLQKEQQRSKDLESRQRSLEQANRSL 423
>Hs4557755 [K] KOG1318 Helix loop helix transcription factor EB
Length = 419
Score = 57.0 bits (136), Expect = 6e-08
Identities = 38/110 (34%), Positives = 61/110 (54%), Gaps = 18/110 (16%)
Query: 248 PKDMNSSALTQDEKIRRRREFHNAVERRRRELIKAKIKELGTLVPPTLLHFDDFGKKVKP 307
P + + AL ++ R++++ HN +ERRRR I +IKELGTL+P + ++
Sbjct: 191 PTESEARALAKE---RQKKDNHNLIERRRRFNINDRIKELGTLIPKS------NDPDMRW 241
Query: 308 NKGTILKRTIEYMDCLKQVLEIQDAKKEELRKKIAELERKKSDLTNSSLL 357
NKGTILK +++Y I+ ++E+ R K E +KK + N LL
Sbjct: 242 NKGTILKASVDY---------IRKLQREQQRAKELENRQKKLEHANRHLL 282
>SPAC3F10.12c [K] KOG1318 Helix loop helix transcription factor EB
Length = 201
Score = 56.2 bits (134), Expect = 1e-07
Identities = 41/136 (30%), Positives = 65/136 (47%), Gaps = 19/136 (13%)
Query: 230 RSNRGSQQFPTSSSLTSTPKDMNSSALTQDEKIRRRREFHNAVERRRRELIKAKIKELGT 289
+ N + TS+ +S M + +E + +R H VERRRRE I IKEL
Sbjct: 54 KKNTAHKNSTTSTVASSGNTTMEKPCVGSEEWYKAKRLSHKEVERRRREAISEGIKELAN 113
Query: 290 LVPPTLLHFDDFGKKVKPNKGTILKRTIEYMDCLKQVLEIQDAKKEELRKKIAELERKKS 349
+VP + NKG+IL+RT +Y+ LK++ EE+ ++ + LE+ +
Sbjct: 114 IVP-----------GCEKNKGSILQRTAQYIRSLKEM--------EEMCREKSNLEKLVA 154
Query: 350 DLTNSSLLQSGAYPKT 365
D T L + A K+
Sbjct: 155 DHTIQELARENARLKS 170
>CE28499 [K] KOG1318 Helix loop helix transcription factor EB
Length = 499
Score = 55.1 bits (131), Expect = 2e-07
Identities = 32/88 (36%), Positives = 52/88 (58%), Gaps = 7/88 (7%)
Query: 263 RRRREFHNAVERRRRELIKAKIKELGTLVPPTLLHFDDFGKKVKPNKGTILKRTIEYMDC 322
RR+++ HN +ERRRR I +IKELG ++P + + +K NKGTILK + +Y+
Sbjct: 237 RRKKDIHNMIERRRRYNINDRIKELGQMLP------KNTSEDMKLNKGTILKASCDYIRV 290
Query: 323 LKQVLEIQDAKKEELRKKIAELERKKSD 350
L++ E Q K ++ +K + K +D
Sbjct: 291 LQKDRE-QAMKTQQQQKSLESTAHKYAD 317
>CE16417 [K] KOG2483 Upstream transcription factor 2/L-myc-2 protein
Length = 124
Score = 55.1 bits (131), Expect = 2e-07
Identities = 36/103 (34%), Positives = 58/103 (55%), Gaps = 13/103 (12%)
Query: 263 RRRREFHNAVERRRRELIKAKIKELGTLVPPTLLHFDDFGKKVKPNKGTILKRTIEYMD- 321
R RE HNA+ERRRR+ IK L +VP D G++V+ ++ ILK+ IE ++
Sbjct: 28 RHAREQHNALERRRRDNIKDMYTSLREVVP------DANGERVQASRAVILKKAIESIEK 81
Query: 322 ------CLKQVLEIQDAKKEELRKKIAELERKKSDLTNSSLLQ 358
L + Q++K +LR++IA L+ KK ++ S++Q
Sbjct: 82 GQSDSATLSVDVAEQESKNAKLREEIARLKAKKDPSSSQSIIQ 124
>CE14416 [K] KOG1318 Helix loop helix transcription factor EB
Length = 498
Score = 55.1 bits (131), Expect = 2e-07
Identities = 32/88 (36%), Positives = 52/88 (58%), Gaps = 7/88 (7%)
Query: 263 RRRREFHNAVERRRRELIKAKIKELGTLVPPTLLHFDDFGKKVKPNKGTILKRTIEYMDC 322
RR+++ HN +ERRRR I +IKELG ++P + + +K NKGTILK + +Y+
Sbjct: 236 RRKKDIHNMIERRRRYNINDRIKELGQMLP------KNTSEDMKLNKGTILKASCDYIRV 289
Query: 323 LKQVLEIQDAKKEELRKKIAELERKKSD 350
L++ E Q K ++ +K + K +D
Sbjct: 290 LQKDRE-QAMKTQQQQKSLESTAHKYAD 316
>Hs22060220 [K] KOG1318 Helix loop helix transcription factor EB
Length = 476
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/102 (36%), Positives = 56/102 (54%), Gaps = 13/102 (12%)
Query: 250 DMNSSALTQDEKIRRRREFHNAVERRRRELIKAKIKELGTLVPPTLLHFDDFGKKVKPNK 309
D S AL ++ R++++ HN +ERRRR I +IKELG L+P +D V+ NK
Sbjct: 224 DAESRALAKE---RQKKDNHNLIERRRRFNINDRIKELGMLIPKA----NDL--DVRWNK 274
Query: 310 GTILKRTIEYMDCLKQVLEIQDAKKEELRKKIAELERKKSDL 351
GTILK +++Y+ +++ L+ K EL LE L
Sbjct: 275 GTILKASVDYIRRMQKDLQ----KSRELENHSRRLEMTNKQL 312
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.311 0.129 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,580,804
Number of Sequences: 60738
Number of extensions: 1068148
Number of successful extensions: 3688
Number of sequences better than 1.0e-05: 9
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 3677
Number of HSP's gapped (non-prelim): 11
length of query: 492
length of database: 30,389,216
effective HSP length: 110
effective length of query: 382
effective length of database: 23,708,036
effective search space: 9056469752
effective search space used: 9056469752
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)