ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1799 check: MH TBLD KOG0892 Cell cycle control, cell division, chromosome partitioning Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair
r_klactV1799 check: MH TBLD KOG0892 Chromatin structure and dynamics Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair
r_klactV1799 check: MH TBLD KOG0892 Replication, recombination and repair Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair
r_klactV1799 check: MH TBLD KOG0892 Signal transduction mechanisms Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1799 639439 631157 -2761
(2761 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBL088c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telom... 774 0.0
SPCC23B6.03c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in ... 351 1e-95
Hs20336203 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in te... 321 9e-87
Hs20336199 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in te... 321 9e-87
At3g48190 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in tel... 301 7e-81
7299977 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telom... 241 2e-62
Hs4502325 [TBLD] KOG0890 Protein kinase of the PI-3 kinase famil... 216 5e-55
Hs22041606 [TBLD] KOG0890 Protein kinase of the PI-3 kinase fami... 216 5e-55
7293222 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 187 2e-46
SPBC216.05 [TBLD] KOG0890 Protein kinase of the PI-3 kinase fami... 186 6e-46
At5g40820 [TBLD] KOG0890 Protein kinase of the PI-3 kinase famil... 176 5e-43
YKL203c [L] KOG0891 DNA-dependent protein kinase 173 3e-42
YJR066w [L] KOG0891 DNA-dependent protein kinase 173 4e-42
7297995 [L] KOG0891 DNA-dependent protein kinase 172 9e-42
SPBC216.07c [L] KOG0891 DNA-dependent protein kinase 171 2e-41
SPBC30D10.10c [L] KOG0891 DNA-dependent protein kinase 168 1e-40
YBR136w [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 168 1e-40
CE28813 [L] KOG0891 DNA-dependent protein kinase 167 3e-40
CE07705 [L] KOG0891 DNA-dependent protein kinase 167 3e-40
ECU02g1130 [TBLD] KOG0890 Protein kinase of the PI-3 kinase fami... 166 5e-40
CE22176 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telom... 165 8e-40
Hs4826730 [L] KOG0891 DNA-dependent protein kinase 163 3e-39
Hs18765739 [L] KOG0891 DNA-dependent protein kinase 149 6e-35
Hs14719394 [L] KOG0891 DNA-dependent protein kinase 149 6e-35
CE28250 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 143 4e-33
CE25103 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 143 4e-33
At1g50030 [L] KOG0891 DNA-dependent protein kinase 142 1e-32
CE27869 [L] KOG0891 DNA-dependent protein kinase 137 2e-31
Hs13654237 [L] KOG0891 DNA-dependent protein kinase 126 6e-28
7290761 [L] KOG0891 DNA-dependent protein kinase 110 4e-23
Hs18589256 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invo... 75 1e-12
Hs4505801 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invol... 75 2e-12
At2g17930 [TBLD] KOG0889 Histone acetyltransferase SAGA TRRAP/TR... 73 7e-12
CE04513 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in i... 70 5e-11
SPAC22E12.16c [TU] KOG0903 Phosphatidylinositol 4-kinase involve... 69 1e-10
YNL267w [TU] KOG0903 Phosphatidylinositol 4-kinase involved in i... 63 6e-09
At1g60490 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invol... 62 1e-08
CE23506 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subu... 59 1e-07
At5g09350 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in... 59 1e-07
At5g64070 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in... 58 2e-07
HsM4505803 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic s... 57 4e-07
Hs21237725 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic s... 57 4e-07
ECU03g1100 [TU] KOG0903 Phosphatidylinositol 4-kinase involved i... 57 5e-07
YHR099w [TBLD] KOG0889 Histone acetyltransferase SAGA TRRAP/TRA1... 55 2e-06
>YBL088c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 2787
Score = 774 bits (1999), Expect = 0.0
Identities = 455/1203 (37%), Positives = 674/1203 (55%), Gaps = 32/1203 (2%)
Query: 1567 ETFLTLTFTDRSCHYQKWISAFICNILLVIVEKFPSFRILALLCDNTAFLHSAIISQLIK 1626
E+F+ T+ + Y W+S F +++ I P L LC + +++ L
Sbjct: 1609 ESFICDTYLSVNEPYNCWLSKFARSLIHQISFNIPPIVCLYPLCKGSTAFCELVLTDLFF 1668
Query: 1627 ILLVSFPKQRSSFLSDILNRADEIFKTEDRTLKMEVITKVFSIIRGMALNGVQNALYVYD 1686
+ PK ++ + I + + +D +K++++ V +IR + +N L +Y
Sbjct: 1669 LSTTYDPKSCLNWSNRIFTQIAMLLHVKDSEIKLKMLFNVIKMIRMGSRCKERNCLRIYS 1728
Query: 1687 KIKLQPVIPIMLSLGSEIWSLMIYEEFYGEYCTGKMLDYELLYQIYSKIDEKDLFYGXXX 1746
+ LQ + I L + + +++EE + ++ L +IY I++ D G
Sbjct: 1729 SLDLQEICQISLKIKEFKFGYLLFEEM--NMPNIREMNINTLQKIYECINDGDFLAGLPV 1786
Query: 1747 XXXXXXXXXXXXKTKFNSYTNFALSNGRFEEGLRNKDSSCLHEFASVTSSNGFTGLATML 1806
+ +++ F +N F+ T +GF GL ++L
Sbjct: 1787 PHSIEGVLNSINRIDSDTWKRFLFNNADFDANYTTSLEEEKESLIKATEDSGFYGLTSLL 1846
Query: 1807 DSNFENPLLSANQYSWALKLNKWDLPIPEARDSFAKSAFSILKDVKEIPDFF--SFDDHI 1864
+S S++ Y W L+L W L P+ DS AK + +K++ + F S + +
Sbjct: 1847 ESRLSG---SSDVYKWNLELGDWKLLTPKVVDSKAKGLYYAIKNLPQDVGFAEKSLEKSL 1903
Query: 1865 LKVMDGGSLLKNSQLNLETMEXXXXXXXXXXXXXADMNTLTTLNNLRVHDTLNADYLPEN 1924
L + D + ++T+ + TL ++ D + +
Sbjct: 1904 LTIFDSRQHFISQTEWMDTLNAIIEFIKIAAIPQDVTSFPQTLMSIMKADKERLNTIDFY 1963
Query: 1925 VFDILHWSRHFFIESKINNTSVIEHAPGSNFTLQLAKILNLVHASTFCRDQGRFQDLINI 1984
SRH + + ++ S+ E+ S + L+L I+ L + G QD +
Sbjct: 1964 DHKTTLKSRHTLM-NVLSRNSLDENVKCSKY-LRLGSIIQLANYVQLAIANGAPQDALRN 2021
Query: 1985 VMTLEAAVDDITNNPAIGPSDTITLFCKRISTVESARMLWANKESAMAINMLEDLLQTNL 2044
+ V +I + ++ +++++ SA LW ++E + ++ DLL
Sbjct: 2022 ATLMSKTVKNIAK---LYDDPSVVSQIEKLASFTSANALWESREYKAPVMIMRDLL---- 2074
Query: 2045 TAVNVENVSLADVQD-----ILMPDAVVDSQLVEWSSFSRHRSPDVIFNDHILYYERDVL 2099
A N +N+S + + D I +P + ++LV+WSS SR I+ I+ ++ +
Sbjct: 2075 -AQNEKNISESILYDDFKLLINVPMDQIKARLVKWSSESRLEPAAAIYEKIIVNWD---I 2130
Query: 2100 NINEPNLRSSICYTYAEFCYKQSQKV-DEGELLYLKQKIAKASNQLQEISSIYKNPKLRD 2158
N+ + S + YT F +Q+QK+ GE+ + + + L+ + IYKN KL +
Sbjct: 2131 NVEDHESCSDVFYTLGSFLDEQAQKLRSNGEIEDREHRSYTGKSTLKALELIYKNTKLPE 2190
Query: 2159 AERKEAKRHHNRLSLQNHHDKDRYNKISSSRIAFVSQALHFFLTTLVHSNSRDAEVVDKF 2218
ERK+AKRH+NR+ LQ + D + + + F+ ALHF+L TLV SN D +++DKF
Sbjct: 2191 NERKDAKRHYNRVLLQYNRDSEVLKALLLQKEKFLWHALHFYLNTLVFSNRYDNDIIDKF 2250
Query: 2219 CSLWFSYSTDDIINSKLQKEIGTVPSFKFLPWVSQMASKLADSVSPFQDTLQLTLKRMLY 2278
C LWF + IN L KEIGT+PS+KFLPWV+Q+ASK++ + FQ LQLT+KR+LY
Sbjct: 2251 CGLWFENDDNSKINQLLYKEIGTIPSWKFLPWVNQIASKISMEENEFQKPLQLTMKRLLY 2310
Query: 2279 KLPYETLYPLISMSLQDSESKVIDPVTKSRVEVVNKIIAALDMYDSGRYGSQFTRPVQAF 2338
KLPY++LY ++S+ L + +S D +++ V KI+ L YD G + ++ PVQ F
Sbjct: 2311 KLPYDSLYSVMSILLYEKQSNK-DTNISQKIQAVKKILLELQGYDRGAFAKKYLLPVQEF 2369
Query: 2339 CSMSVALACHKIPPKMKFLQLDTLNIGKYWLETLPKVHLPLPTLPVKITCSQDGRREGRS 2398
C MSV LA K K L+L L IG+YWL+ L LPLPT + S DGR+ R
Sbjct: 2370 CEMSVELANLKFVQNTKTLRLANLKIGQYWLKQLNMEKLPLPTSNFTVKSSADGRK-ARP 2428
Query: 2399 YISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKIL 2458
YI S++ V I+++GLSLPKI TF +SDGT + L+KGSNDDLRQDAIMEQVF+QVNK+L
Sbjct: 2429 YIVSVNETVGITTTGLSLPKIVTFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVL 2488
Query: 2459 KANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTMK 2518
+ +K R +L +RTY+V+PLGP+AG+IEFVANS SLH IL LH ND+I+FD+ARK MK
Sbjct: 2489 QNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDKITFDQARKGMK 2548
Query: 2519 AAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLL 2578
A Q S EER+ + +IT +IKPQLR FFF SF DW+E++ YTK V SSIVGY+L
Sbjct: 2549 AVQTKSNEERLKAYLKITNEIKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYIL 2608
Query: 2579 GLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGFGVAGIEGL 2638
GLGDRHLNNIL+D TGEPIHIDLG+AFDQGKLLPIPELVPFRLTRDIVDGFGV G++GL
Sbjct: 2609 GLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKLLPIPELVPFRLTRDIVDGFGVTGVDGL 2668
Query: 2639 FRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAKFTGDYDEEEISVS 2698
FR +CERV+ VL+ + +++CVLN+LKWDPLYSW M+P+KK + + + E +
Sbjct: 2669 FRRSCERVYAVLRKDYVKVMCVLNILKWDPLYSWVMSPVKKY----EHLFEEEHEITNFD 2724
Query: 2699 DADFSXXXXXXXXXXXSIRALKGVESKLYGDGLSVEAIVQELLSSATDKQNLATIYMGWS 2758
+ S RALKGVE KL G+GLSVE+ VQ+L+ ATD NL+ IYMGWS
Sbjct: 2725 NVSKFISNNDRNENQESYRALKGVEEKLMGNGLSVESSVQDLIQQATDPSNLSVIYMGWS 2784
Query: 2759 PFY 2761
PFY
Sbjct: 2785 PFY 2787
Score = 561 bits (1446), Expect = e-159
Identities = 392/1381 (28%), Positives = 685/1381 (49%), Gaps = 62/1381 (4%)
Query: 14 LSSLKLKTRXXXXXXXXXXXKTSPTEVPVKAFSPILDAIITIIESEKTRYEKT--RLENG 71
LSS K+K R K P +P KA S +A++ ++ SE T+Y L
Sbjct: 13 LSSTKIKERNNALDELTTILKEDPERIPTKALSTTAEALVELLASEHTKYCDLLRNLTVS 72
Query: 72 KDARIELYENRLGSAAYTLRLFVERNCERFKPKHIKLLSMTLFELMTRPRSRSLITSVAD 131
++ L ENRL + +Y LRLFVE++CERFK K +KLL + ELM + S+SL+ +V+
Sbjct: 73 TTNKLSLSENRLSTISYVLRLFVEKSCERFKVKTLKLLLAVVPELMVKDGSKSLLDAVSV 132
Query: 132 HLTYSLVALCGSPVFQCNFELHQWISLSHDISDAVTYHLDVSYNDKIIANLLQTLLELFQ 191
HL+++L AL S F+ F +HQWISL I + + +S DK + N + LL L
Sbjct: 133 HLSFALDALIKSDPFKLKFMIHQWISLVDKICEYFQSQMKLSMVDKTLTNFISILLNLLA 192
Query: 192 IDTIGIEDIATPVVRMTIKYLTLITKENTNTRTILTLVNSAILRLHLIRFQDVINLSYYT 251
+DT+GI + + I +L L KEN NTR I++L+N IL+ H D + L
Sbjct: 193 LDTVGIFQVTRTITWTVIDFLRLSKKENGNTRLIMSLINQLILKCHCFSVIDTLMLIKEA 252
Query: 252 IKHLLRIKLT-NENNIGEIARFNLMISEVLYNKTPIIVGEDKDQSYVNKEKLLPALQDYL 310
+ L I T NE +++ F++M SE++ +K P ++G++ + E L+ ++Y+
Sbjct: 253 WSYNLTIGCTSNELVQDQLSLFDVMSSELMNHKLPYMIGQENYVEELRSESLVSLYREYI 312
Query: 311 IHSLKQYDHTKFTLDCVTF--IDGPASSKFNWYSFSDICQNEKNCLEDIWLYALSLTMML 368
+ L Y FT++ V F I G + K +W++ D ++ +WL L +T L
Sbjct: 313 LLRLSNYKPQLFTVNHVEFSYIRG-SRDKNSWFALPDFRLRDRGG-RSVWLKILGITKSL 370
Query: 369 KANYQFLEYKESSLAGGSLLFKRRKVKDTFAHMLKDSLTYDDFLCNCIDSDSI-KIKTTG 427
+ E+ SLLFKRRK +L+ S D FL + ++ +S + + G
Sbjct: 371 LTYFALNRKNENY----SLLFKRRKCDSDIPSILRISDDMDTFLIHLLEENSSHEFEVLG 426
Query: 428 LHIGLLYLSIFDCSNIELSHLKEELFRCSQDVR-FMLLCLSCFIPMCSQSKNSFSPEEEI 486
L + Y ++ D + LKE LF + ++ F +C S FIP+ SQ + S +
Sbjct: 427 LQLCSFYGTLQDFTKSFAEQLKELLFSKFEKIQCFNWVCFS-FIPLLSQKECELSNGDMA 485
Query: 487 RLFKMCVPLLKTSNGCKTACSLLYKLIEFQLEPIKDKSVLQQMSDLYLLSDVNGPALVCN 546
RLFK+C+PL+K++ C+ +C LL I+F + + D+ + Q+ DLY LSD+ GP LV N
Sbjct: 486 RLFKVCLPLVKSNESCQLSCLLLANSIKFSKQLLSDEKTINQIYDLYELSDILGPILVTN 545
Query: 547 ESFKFWMHLHYYAKTFQTVK--SPITYVFSWLYARWDQLFTLVVSETHFYVFASWLCGCT 604
ESF W +L Y K FQ++ S +F WL ++W+QL + F F SWL
Sbjct: 546 ESFMLWGYLQYVGKDFQSMNGISSADRIFEWLKSKWNQLRGTDAKQDQFCNFISWLGNKY 605
Query: 605 HTTFP----TFEYSRPSLF-----HDTWMGLSEERASITGFSLTIRTIELRKQKF--APV 653
P E + P H W E+R + G ++ F V
Sbjct: 606 DPENPFNDKKGEGANPVSLCWDESHKIWQHFQEQREFLLGVKPEEKSECFNTPFFNLPKV 665
Query: 654 FCEEAERVRFMYKLFDLIDESAISA-----TFIDRAIQVLRTIESLVGQRNYTDYLSRFK 708
+ +Y+L + I+ A S+ T++ + IQ+ +++L G ++++++ +K
Sbjct: 666 SLDLTRYNEILYRLLENIESDAFSSPLQKFTWVAKLIQI---VDNLCGDSTFSEFIAAYK 722
Query: 709 EIFLLSSSVIDFGQNAQIFSVMEGMISLKDSLLRHIIMDILPTEKVLSTFMQRLAEHTQQ 768
L++ + F S E ++S++ + H+++D + +++++ F+ R+ ++ Q
Sbjct: 723 RTTLITIPQLSFDSQNSYQSFFEEVLSIRTINVDHLVLDKINMKEIVNDFI-RMQKNKSQ 781
Query: 769 TSHQDEFLSHHAKPEAGSIPISEMIEIGFEFALQVHS-VSKAF-------------DPLS 814
T +++ + + IG F +HS + KA + L
Sbjct: 782 TG--TSAINYFEASSEDTTQNNSPYTIGGRFQKPLHSTIDKAVRAYLWSSRNKSISERLV 839
Query: 815 SFILYSKKLSLPMLNRTLPNLITYLEN--NENEIPTASLERLTQFLGSSLLAPSFDTSST 872
+ + +S +S + L + +L+ E LE T+ LG LL + +S+
Sbjct: 840 AILEFSDCVSTDVFISYLGTVCQWLKQAIGEKSSYNKILEEFTEVLGEKLLCNHYSSSNQ 899
Query: 873 SMKLLTRYLEGISKYWVMEDRSQVLTADCNDIFDWIVTQYDESSFSGVEALYELARFMTL 932
+M LLT Y+E I W+ Q L +DCNDI DWI+++++++SF+GV L+ +
Sbjct: 900 AMLLLTSYIEAIRPQWLSYPE-QPLNSDCNDILDWIISRFEDNSFTGVAPTVNLSMLLLS 958
Query: 933 LLEKYNLSNSSISGGKQRVFKILSGCITRLPKYLTNRVVSLLGTYVKRVGVTNQRILFKE 992
LL+ ++LS+ SI GGKQRVF C+ +L +++ + +Y+ +V NQ I+F E
Sbjct: 959 LLQNHDLSHGSIRGGKQRVFATFIKCLQKLDSSNIINIMNSISSYMAQVSYKNQSIIFYE 1018
Query: 993 LLQRFNPPQESVETAAFFSLTCTKLSLINEFYLLNSILHLLDNTNFSHLLLYVEKSLDTI 1052
+ F PPQ+S+E +AF+SL + LSL++ L+ S+ ++ + F+H +++++L+ I
Sbjct: 1019 IKSLFGPPQQSIEKSAFYSLAMSMLSLVSYPSLVFSLEDMMTYSGFNHTRAFIQQALNKI 1078
Query: 1053 STFYGLCSKQDLFHQCRYFIIDQWF--TKSAKSKIYEPSIWKVELFEF-EFDEFCIRYQM 1109
+ + + +LF C++ +I WF TK SK+ + W + LF F + EF RY +
Sbjct: 1079 TVAFRYQNLTELFEYCKFDLIMYWFNRTKVPTSKLEKE--WDISLFGFADIHEFLGRYFV 1136
Query: 1110 ELTSFFFAKSSTYYYIIDHLKKLLNLKQEALLTKYIAPTIALSYVDSGVKDLIFDIAADL 1169
E+++ +F++ +I+D L + L+ I L+++ GV +LIFDI +
Sbjct: 1137 EISAIYFSQGFNQKWILDMLHAITGNGDAYLVDNSYYLCIPLAFISGGVNELIFDILPQI 1196
Query: 1170 LGRKFPNVLTINLDDVIYYFIKLSDLSNLATSLTFWCKIFNSSRFTNMLHYNSSNCMQLN 1229
G+ ++ + I+ +DL +L + K+F +S + L NSS M+
Sbjct: 1197 SGKTTVKYHKKYRLLMLKWIIRFTDLGSLTELRSTVEKLFPTSYLSPYLFENSSVSMRYQ 1256
Query: 1230 DNVAIAFPIVYKVLKKNVFTDIDDGRSFEYVIQRLVMDLQNCVLIDQKIRVLRQIKLLVL 1289
+ I + +++ + ++ F+ + ++ DL+ K+R R++K L +
Sbjct: 1257 YPLHIPLALGATLVQTQFAHEKNNTHEFKLLFLSVITDLEKTSTYIGKLRCARELKYLFV 1316
Query: 1290 FFEHKLTLFKDIDFFLLELSKFLFNADIFSEVYGFILDLLEFSANNKMDVARSLTELMRF 1349
+E+ L ++F ++ LSKFL + I EV LL + N ++ SL L F
Sbjct: 1317 LYENVLVKSSTLNFIIIRLSKFLIDTQIHDEVITIFSSLLNLADKNTFEIEPSLPNL--F 1374
Query: 1350 C 1350
C
Sbjct: 1375 C 1375
>SPCC23B6.03c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 2812
Score = 351 bits (900), Expect = 1e-95
Identities = 241/752 (32%), Positives = 387/752 (51%), Gaps = 39/752 (5%)
Query: 2019 SARMLWANKESAMAINMLEDLLQTNLTAVNVENVSLADVQDILMPDAVVDSQLVEWSSFS 2078
S+++LW E AI ML + SL+ + P ++ + L W +
Sbjct: 2089 SSKILWQRDEKIDAIGMLSE--------------SLSKTNSSIFP-SISYAYLGNWLYTT 2133
Query: 2079 RHRSPDVIFNDHILYYERDVLNINEPNLR--SSICYTYAEFCYKQSQKVDEGELLYLKQK 2136
+ +++ + Y+E+ + +++ N + + I +A+FC D E +K
Sbjct: 2134 KSEKTELVSKN---YFEKSLSHMSHLNAKEKAKIYCMFAQFCDNNYSSPDLTEDFKRMEK 2190
Query: 2137 IA-KASNQLQEISSIYKNPKLRDAERKEAKRHHNRLSLQNHHDKDRYNKISSSRIAFVSQ 2195
+ + N +Q++ N E K K HH+R D+ Y ++S+ R ++Q
Sbjct: 2191 LYFEKKNDIQQLERSIVNAS-NMKEEKMLKNHHSREMSSFIIDEREYLRMSTFRSKMLTQ 2249
Query: 2196 ALHFFLTTLVHSNSRDAEVVDKFCSLWFSYSTDDIINSKLQKEIGTVPSFKFLPWVSQMA 2255
++ +L L S+ D ++ + C++W S S D +N+ LQ + +P KF+P Q+A
Sbjct: 2250 SITHYLKCLSESDENDV-LISRCCTMWLSNSHLDELNNSLQHYLQNLPCKKFIPVFYQLA 2308
Query: 2256 SKLADSVSPFQDTLQLTLKRMLYKLPYETLYPLISMSLQDSESKVIDPVTKSRVEVVNKI 2315
++L + S FQ +L + PY +L+ L S+ E + +D SR V KI
Sbjct: 2309 ARLMNENSKFQQSLTSICYNVGRNHPYHSLHVLFSLVSNVPEIENLD--AGSRYRAVKKI 2366
Query: 2316 IAALDMYDSGRYGSQFTRPVQAFCSMSVALACHKIPPKMKFLQLDTLNIGKYWLETLPKV 2375
LD+ + S + V+LA K+ K++L+
Sbjct: 2367 ---LDLLKVNQGLSNLVTKLLCSFENYVSLAEWNPRSKVDSTSFSRFPGYKWFLKDAANY 2423
Query: 2376 HLPLPTLPVKITCSQDGRREGRSYISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLK 2435
LP T+ VK+ + G +SS D + +S G++ PK+ T S+G ++ L+K
Sbjct: 2424 GLPPITMNVKV--NDTGDYSNIPTVSSFDDTIHFAS-GINAPKVITCLGSNGHTYKQLVK 2480
Query: 2436 GSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSL 2495
G NDDLRQDA+MEQVF+QVN L++ + T ++NLS+RTY+VIPL + G+IE+V +++ L
Sbjct: 2481 GGNDDLRQDAVMEQVFEQVNGFLRSYRKTSQRNLSMRTYKVIPLALKTGVIEWVQDTIPL 2540
Query: 2496 HDILLNLHC---NDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFV 2552
+ L + H E S RK + Q +E R+ + + +P R FF +S+
Sbjct: 2541 GEYLDSAHKVYHPKEWSLSTCRKLIAEKQMEDLETRLKVYDLVCRHYRPVFRHFFLESYA 2600
Query: 2553 HAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLL 2612
W+ ++ Y +S +S++G++LGLGDRH NILID +GE IHIDLG+AF+QGK L
Sbjct: 2601 DPVQWFTTQTNYARSTAVASVLGHVLGLGDRHGQNILIDKTSGEVIHIDLGIAFEQGKKL 2660
Query: 2613 PIPELVPFRLTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSW 2672
P+PE VPFRLTRD+VDG G+ G+EG+FR E + L+ E++ LL VL VL++DPL+SW
Sbjct: 2661 PVPECVPFRLTRDVVDGMGITGVEGVFRRCMEFTLETLRREEDSLLSVLEVLRYDPLFSW 2720
Query: 2673 KMTPL---KKQRLQAKFTGDYDEEEISV-SDADFSXXXXXXXXXXXSIRALKGVESKLYG 2728
++PL KKQ++Q + + I+ + D + RA+ V KL
Sbjct: 2721 LISPLRRMKKQKMQLENFNQPESGNITTDASRDPKIQRNNVSGESEAERAILKVRQKL-S 2779
Query: 2729 DGLSVEAIVQELLSSATDKQNLATIYMGWSPF 2760
LSVEA V EL+ A D LA ++ GWS F
Sbjct: 2780 STLSVEASVGELIRIAQDPSYLALMFCGWSAF 2811
>Hs20336203 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 3056
Score = 321 bits (823), Expect = 9e-87
Identities = 232/787 (29%), Positives = 381/787 (47%), Gaps = 73/787 (9%)
Query: 2017 VESARMLWANKESAMAINMLEDLLQTNLTAVNVENVSLADVQDILMPDAVVDSQLVEWSS 2076
+E A++ WA KE ++A+++L+ +++ + N SL + W +
Sbjct: 2293 LEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECL------RVCGNWLA 2346
Query: 2077 FSRHRSPDVIFNDHILYYERDVLNINEP------NLRSSICYTYAEFCYKQSQKVDEGEL 2130
+ +P VI ++ N + N + + A F Q Q+++
Sbjct: 2347 ETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIEN--- 2403
Query: 2131 LYLKQKIAKASNQLQEISSIYKNPKLRDAERKEAKRHHNRLSLQNHH----DKDRYNKIS 2186
Y+K S++ + ++ K K +E K NR +++ D+ +
Sbjct: 2404 -YMK------SSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALK 2456
Query: 2187 SSRIAFVSQALHFFLTTLVHSNSRDAEVVDKFCSLWFSYSTDDIINSKLQKEIGTVPSFK 2246
R F+ +A+ ++ L+ D V + CSLW S +N ++++ +P++K
Sbjct: 2457 EDRKRFLCKAVENYINCLLSGEEHDMWVF-RLCSLWLENSGVSEVNGMMKRDGMKIPTYK 2515
Query: 2247 FLPWVSQMASKLADSVSP---FQDTLQLTLKRMLYKLPYETLYPLISMSLQDSESKVIDP 2303
FLP + Q+A+++ + F + L + R+ P+ TL+ +++++ + + + P
Sbjct: 2516 FLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKP 2575
Query: 2304 VTKSRVEVVNKIIAALDMYDSGRYGS-------------QFTRPVQAFCSMSVALACHKI 2350
R + + D R + Q R V+A C + LA +
Sbjct: 2576 EVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILA--NL 2633
Query: 2351 PPKMKFLQLDTLNIGKYWLETLPK--VHLPLPTLPVKITCSQDGRREGRSYISSIDPKVL 2408
Q +NI T K + +PT+ +K+ G I S +
Sbjct: 2634 DATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKV--DHTGEYGNLVTIQSFKAEFR 2691
Query: 2409 ISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQN 2468
++ G++LPKI SDG R L+KG DDLRQDA+M+QVF+ N +L+ N TRK+
Sbjct: 2692 LAG-GVNLPKIIDCVGSDGKERRQLVKG-RDDLRQDAVMQQVFQMCNTLLQRNTETRKRK 2749
Query: 2469 LSVRTYEVIPLGPRAGLIEFVANSMSLHDILLN--------LHCNDEISFDKARKTMKAA 2520
L++ TY+V+PL R+G++E+ ++ + + L+N ND +F + +K M
Sbjct: 2750 LTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAF-QCQKKMMEV 2808
Query: 2521 QNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGL 2580
Q S EE+ F + + +P R F + F+ W+E R YT+SV TSSIVGY+LGL
Sbjct: 2809 QKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGL 2868
Query: 2581 GDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGFGVAGIEGLFR 2640
GDRH+ NILI+ ++ E +HIDLGVAF+QGK+LP PE VPFRLTRDIVDG G+ G+EG+FR
Sbjct: 2869 GDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR 2928
Query: 2641 NNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAK----------FTGDY 2690
CE+ +V+++ +E LL ++ VL +DPL+ W M PLK LQ + D
Sbjct: 2929 RCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADD 2988
Query: 2691 DEEEISVSDADFSXXXXXXXXXXXSIRALKGVESKLYGDGLSVEAIVQELLSSATDKQNL 2750
E + ++SD D S LKGVE G LSV V L+ A D +NL
Sbjct: 2989 QECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEE---GTVLSVGGQVNLLIQQAIDPKNL 3045
Query: 2751 ATIYMGW 2757
+ ++ GW
Sbjct: 3046 SRLFPGW 3052
>Hs20336199 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 1708
Score = 321 bits (823), Expect = 9e-87
Identities = 232/787 (29%), Positives = 381/787 (47%), Gaps = 73/787 (9%)
Query: 2017 VESARMLWANKESAMAINMLEDLLQTNLTAVNVENVSLADVQDILMPDAVVDSQLVEWSS 2076
+E A++ WA KE ++A+++L+ +++ + N SL + W +
Sbjct: 945 LEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECL------RVCGNWLA 998
Query: 2077 FSRHRSPDVIFNDHILYYERDVLNINEP------NLRSSICYTYAEFCYKQSQKVDEGEL 2130
+ +P VI ++ N + N + + A F Q Q+++
Sbjct: 999 ETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIEN--- 1055
Query: 2131 LYLKQKIAKASNQLQEISSIYKNPKLRDAERKEAKRHHNRLSLQNHH----DKDRYNKIS 2186
Y+K S++ + ++ K K +E K NR +++ D+ +
Sbjct: 1056 -YMK------SSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALK 1108
Query: 2187 SSRIAFVSQALHFFLTTLVHSNSRDAEVVDKFCSLWFSYSTDDIINSKLQKEIGTVPSFK 2246
R F+ +A+ ++ L+ D V + CSLW S +N ++++ +P++K
Sbjct: 1109 EDRKRFLCKAVENYINCLLSGEEHDMWVF-RLCSLWLENSGVSEVNGMMKRDGMKIPTYK 1167
Query: 2247 FLPWVSQMASKLADSVSP---FQDTLQLTLKRMLYKLPYETLYPLISMSLQDSESKVIDP 2303
FLP + Q+A+++ + F + L + R+ P+ TL+ +++++ + + + P
Sbjct: 1168 FLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKP 1227
Query: 2304 VTKSRVEVVNKIIAALDMYDSGRYGS-------------QFTRPVQAFCSMSVALACHKI 2350
R + + D R + Q R V+A C + LA +
Sbjct: 1228 EVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILA--NL 1285
Query: 2351 PPKMKFLQLDTLNIGKYWLETLPK--VHLPLPTLPVKITCSQDGRREGRSYISSIDPKVL 2408
Q +NI T K + +PT+ +K+ G I S +
Sbjct: 1286 DATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKV--DHTGEYGNLVTIQSFKAEFR 1343
Query: 2409 ISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQN 2468
++ G++LPKI SDG R L+KG DDLRQDA+M+QVF+ N +L+ N TRK+
Sbjct: 1344 LAG-GVNLPKIIDCVGSDGKERRQLVKG-RDDLRQDAVMQQVFQMCNTLLQRNTETRKRK 1401
Query: 2469 LSVRTYEVIPLGPRAGLIEFVANSMSLHDILLN--------LHCNDEISFDKARKTMKAA 2520
L++ TY+V+PL R+G++E+ ++ + + L+N ND +F + +K M
Sbjct: 1402 LTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAF-QCQKKMMEV 1460
Query: 2521 QNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGL 2580
Q S EE+ F + + +P R F + F+ W+E R YT+SV TSSIVGY+LGL
Sbjct: 1461 QKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGL 1520
Query: 2581 GDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGFGVAGIEGLFR 2640
GDRH+ NILI+ ++ E +HIDLGVAF+QGK+LP PE VPFRLTRDIVDG G+ G+EG+FR
Sbjct: 1521 GDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFR 1580
Query: 2641 NNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAK----------FTGDY 2690
CE+ +V+++ +E LL ++ VL +DPL+ W M PLK LQ + D
Sbjct: 1581 RCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADD 1640
Query: 2691 DEEEISVSDADFSXXXXXXXXXXXSIRALKGVESKLYGDGLSVEAIVQELLSSATDKQNL 2750
E + ++SD D S LKGVE G LSV V L+ A D +NL
Sbjct: 1641 QECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEE---GTVLSVGGQVNLLIQQAIDPKNL 1697
Query: 2751 ATIYMGW 2757
+ ++ GW
Sbjct: 1698 SRLFPGW 1704
>At3g48190 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 3856
Score = 301 bits (772), Expect = 7e-81
Identities = 202/619 (32%), Positives = 306/619 (48%), Gaps = 35/619 (5%)
Query: 2157 RDAERKEAKRHHNRLSLQNHHDKDRYNKISSSRIAFVSQALHFFLTTLVHSNSRDAEVVD 2216
+ AE+ + L Q DK+ K+ R F+ AL + L + D VV
Sbjct: 3251 KKAEQSDYSLKIQDLQKQLTMDKEEAEKLQVDRDNFLKLALEGYKRCLEIGDKYDVRVVF 3310
Query: 2217 KFCSLWFSYSTDDIINSKLQKEIGTVPSFKFLPWVSQMASKLADSV-----SPFQDTLQL 2271
+ S+WFS ++ + + I V S+KF+P V Q+AS+L S + FQ L
Sbjct: 3311 RQVSMWFSLASQKNVIDNMLSTIKEVQSYKFIPLVYQIASRLGSSKDESGSNSFQSALVS 3370
Query: 2272 TLKRMLYKLPYETLYPLISMSLQDSESKVIDPVTKSRVEVVNKIIAALDMYDSGRYGSQF 2331
+++M PY T+ L++++ D V++ K+ A + D Y
Sbjct: 3371 LIRKMAIDHPYHTILQLLALANGDRIKDNQRSRNSFVVDMDKKLAAEHLLQDVSHYHGPM 3430
Query: 2332 TRPVQAFCSMSVALA---CHKIPPKMKFLQLDTLNIGKYWLETLPKVHLPLPTLPVKITC 2388
R ++ + + LA + K + K LE +P V T+PV +C
Sbjct: 3431 IRQMKQLVDIYIKLAELETRREDTNRKVALPREIRSVKQ-LELVPVV---TATIPVDRSC 3486
Query: 2389 SQDGRREGR-SYISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIM 2447
+ EG + + V + + G++ PK+ SDG +++ L K NDDLRQDA+M
Sbjct: 3487 QYN---EGSFPFFRGLSDSVTVMN-GINAPKVVECFGSDGQKYKQLAKSGNDDLRQDAVM 3542
Query: 2448 EQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDE 2507
EQ F VN L N+ T K+ L+VRTY+VIP P AG++E+V ++ L D L+ ++
Sbjct: 3543 EQFFGLVNTFLHNNRDTWKRRLAVRTYKVIPFTPSAGVLEWVDGTIPLGDYLIGSSRSEG 3602
Query: 2508 I---------SFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDWY 2558
+ K R+ M +A+ ++ F + +P + FF + F+ DW+
Sbjct: 3603 AHGRYGIGNWKYPKCREHMSSAK-----DKRKAFVDVCTNFRPVMHYFFLEKFLQPADWF 3657
Query: 2559 ESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELV 2618
R YT+SV SS+VGY++GLGDRH NILID T E +HIDLGVAF+QG +L PE V
Sbjct: 3658 VKRLAYTRSVAASSMVGYIVGLGDRHAMNILIDQATAEVVHIDLGVAFEQGLMLKTPERV 3717
Query: 2619 PFRLTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLK 2678
PFRLTRDI+DG G+ G+EG+FR CE V++ KE LL ++ V DPLY W ++PLK
Sbjct: 3718 PFRLTRDIIDGMGITGVEGVFRRCCEETLSVMRTNKEALLTIVEVFIHDPLYKWALSPLK 3777
Query: 2679 KQRLQAKFTGDYDEEEISVSDADFSXXXXXXXXXXXSIRALKGVESKLYGDGLSVEAIVQ 2738
+ Q K T DYD + +F + L G E G+ S+ Q
Sbjct: 3778 ALQRQ-KETEDYDGMNLEGLQEEFEGNKDATRALMRVKQKLDGYEG---GEMRSIHGQAQ 3833
Query: 2739 ELLSSATDKQNLATIYMGW 2757
+L+ A D L+ ++ GW
Sbjct: 3834 QLIQDAIDTDRLSHMFPGW 3852
>7299977 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 2429
Score = 241 bits (614), Expect = 2e-62
Identities = 182/596 (30%), Positives = 277/596 (45%), Gaps = 45/596 (7%)
Query: 2178 DKDRYNKISSSRIAFVSQALHFFLTTLVHSNSRDAEVVDKFCSLWFSYSTDDIINSKLQK 2237
D+ + N+I ++ AL ++ + + + + SLWF+ +T ++
Sbjct: 1863 DEQQLNQIEEKLTEYLRLALTNYMAYCRLDSGFSSAAIYRIISLWFTNATSKQCQECIKD 1922
Query: 2238 EIGTVPSFKFLPWVSQMASKLADSVSPFQDTLQLTLKRMLYKLPYET---LYPLISMSLQ 2294
EI TVPS+KF+ +Q+ ++L + L L + PY T LYPL+ L
Sbjct: 1923 EILTVPSYKFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHLD 1982
Query: 2295 DSESKVIDPVTKSRVEVVNKIIAALDMYD--SGRYGSQFTRPVQAFCSMSVALACHKIPP 2352
S R + KIIA + + +G Q + A + + + P
Sbjct: 1983 GENSNT------ERSGIARKIIAMICEKNGTAGECSKQLESLLPALITFANEGKTNDNRP 2036
Query: 2353 KMKFLQLDTLNIGKYWLETLPKVHLPLPTLPVKITCSQDGRREGRSYISSID-PKVLISS 2411
++ + + W L VH P LPV + + S IS +
Sbjct: 2037 VSDSVRNKQFDKVRRW-RNLNAVHCPTLELPVMPS-------KEYSIISVVKWTNETTQC 2088
Query: 2412 SGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSV 2471
GL+ P SDG L+KG DDLRQDA+M+QVF VN++L + ++ L +
Sbjct: 2089 GGLNAPVKIMCVCSDGKIRAQLVKGK-DDLRQDAVMQQVFGIVNELLNQDSEFIERKLKL 2147
Query: 2472 RTYEVIPLGPRAGLIEFVANSMSLHDILL-----NLHCN---DEISFDKARKTMKAAQNH 2523
RTY+V PL R+G++E+ NS+ + L+ H ++ + +K RK
Sbjct: 2148 RTYKVTPLSMRSGILEWCTNSVPVGHYLVVEGKGGAHARYRPNDWNNNKCRKLSSDHLKS 2207
Query: 2524 SVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDR 2583
E R + +I E IKP F + F W+E R YT SV T+S+VGY+LGLGDR
Sbjct: 2208 PKETRYAIYKKICENIKPVFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDR 2267
Query: 2584 HLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGFGVAGIEGLFRNNC 2643
H NIL+D +T E IHID G+AF+QGK+ PE VPFRLTRD V G+ G +G+F +C
Sbjct: 2268 HTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLTRDFVAPMGICGTKGVFAKSC 2327
Query: 2644 ERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAKFTGDYDEEEISVSDADFS 2703
E +L+ K +L VL +DPL+ W + K+ Q+ EE +++
Sbjct: 2328 EATMHILRRYKSVFTTILEVLLYDPLFIWGVLKKKQSPQQS------GEESVNL------ 2375
Query: 2704 XXXXXXXXXXXSIRALKGVESKLYGDGLSVEAIVQELLSSATDKQNLATIYMGWSP 2759
L G E+ GD +VEA V+ L++ AT NL ++ GW P
Sbjct: 2376 ---VAQRALLLVQNKLDGREAGTMGDS-NVEAQVERLINEATLPSNLCMLFPGWDP 2427
>Hs4502325 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2644
Score = 216 bits (549), Expect = 5e-55
Identities = 181/689 (26%), Positives = 314/689 (45%), Gaps = 70/689 (10%)
Query: 2116 EFCYKQSQKVDEGELLYLKQKIAKASNQLQEISSIYKN----PKLRDAERKEAKRHHNRL 2171
E C+ +++ EG+ + + + + E ++ +++ K +D +
Sbjct: 1981 ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF 2040
Query: 2172 SLQNHHDK------DRYNKISSSRIAFVSQALHFFLTTLVHSNSRDAEVVDKFCSLWFSY 2225
L ++DK D + I ++ LHF +L + N + + + +LW Y
Sbjct: 2041 YLAKYYDKLMPMVTDNKMEKQGDLIRYI--VLHFG-RSLQYGNQFIYQSMPRMLTLWLDY 2097
Query: 2226 ST-----------------DDI--INSKLQKEIGTVPSFKFLPWVSQMASKLADSVSPFQ 2266
T +D+ IN + + + ++FL SQ+ S++ S
Sbjct: 2098 GTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHS----H 2153
Query: 2267 DTLQLTLKRMLYKLPYETLYPLISMSLQDSESKVIDPVTKSRV-EVVNKII---AALDMY 2322
D + + L ++ K+ YP +M + + SK P+ +R E++NK I +L+ +
Sbjct: 2154 DEVFVVLMEIIAKV--FLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKF 2211
Query: 2323 DSGRYGSQFTRPVQAFCSMSVALACHKIPPKMKFLQLDTLNIGKYWLETL-PKVHLPLPT 2381
++ T + C+ V + + F L L + E L P + +PT
Sbjct: 2212 VGD--ATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPT 2269
Query: 2382 LPVKIT-----CSQDGRREGRSYISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKG 2436
LP + S + +YI+ D V I +S L PK + SDG + ++ K
Sbjct: 2270 LPSILGTHANHASHEPFPGHWAYIAGFDDMVEILAS-LQKPKKISLKGSDGKFYIMMCK- 2327
Query: 2437 SNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLH 2496
DDLR+D + + +NK L+ + +R++ L +RTY VIPL G+IE+V N+ L
Sbjct: 2328 PKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLR 2387
Query: 2497 DILLNLHCNDEISFD-KARKTMKAAQNHSVEERVLTFSR-ITEKIKPQLRRFFFQSFVHA 2554
IL L+ + K + ++ ++ E++ F + + P +F ++F
Sbjct: 2388 PILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDP 2447
Query: 2555 HDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPI 2614
WY SR+ Y +S S+VGY+LGLGDRH NIL D TGE +H+D F++G+ +
Sbjct: 2448 TSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEV 2507
Query: 2615 PELVPFRLTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKM 2674
PE+VPFRLT ++V+G G G EGLFR CE ++++D++E L+ VL DPL W
Sbjct: 2508 PEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSK 2567
Query: 2675 TPLKKQRLQAKFTGDYDEEEISVSDADFSXXXXXXXXXXXSIRALKGV---ESKLYGDGL 2731
+ TG+ E+ D + L+GV +++ G L
Sbjct: 2568 PVKGHSKAPLNETGEVVNEKAKTHVLDIE-------------QRLQGVIKTRNRVTGLPL 2614
Query: 2732 SVEAIVQELLSSATDKQNLATIYMGWSPF 2760
S+E V L+ ATD+ L +Y+GW+P+
Sbjct: 2615 SIEGHVHYLIQEATDENLLCQMYLGWTPY 2643
>Hs22041606 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 1212
Score = 216 bits (549), Expect = 5e-55
Identities = 181/689 (26%), Positives = 314/689 (45%), Gaps = 70/689 (10%)
Query: 2116 EFCYKQSQKVDEGELLYLKQKIAKASNQLQEISSIYKN----PKLRDAERKEAKRHHNRL 2171
E C+ +++ EG+ + + + + E ++ +++ K +D +
Sbjct: 549 ELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHF 608
Query: 2172 SLQNHHDK------DRYNKISSSRIAFVSQALHFFLTTLVHSNSRDAEVVDKFCSLWFSY 2225
L ++DK D + I ++ LHF +L + N + + + +LW Y
Sbjct: 609 YLAKYYDKLMPMVTDNKMEKQGDLIRYI--VLHFG-RSLQYGNQFIYQSMPRMLTLWLDY 665
Query: 2226 ST-----------------DDI--INSKLQKEIGTVPSFKFLPWVSQMASKLADSVSPFQ 2266
T +D+ IN + + + ++FL SQ+ S++ S
Sbjct: 666 GTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHS----H 721
Query: 2267 DTLQLTLKRMLYKLPYETLYPLISMSLQDSESKVIDPVTKSRV-EVVNKII---AALDMY 2322
D + + L ++ K+ YP +M + + SK P+ +R E++NK I +L+ +
Sbjct: 722 DEVFVVLMEIIAKV--FLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKSLEKF 779
Query: 2323 DSGRYGSQFTRPVQAFCSMSVALACHKIPPKMKFLQLDTLNIGKYWLETL-PKVHLPLPT 2381
++ T + C+ V + + F L L + E L P + +PT
Sbjct: 780 VGD--ATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIPLQSVMIPT 837
Query: 2382 LPVKIT-----CSQDGRREGRSYISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKG 2436
LP + S + +YI+ D V I +S L PK + SDG + ++ K
Sbjct: 838 LPSILGTHANHASHEPFPGHWAYIAGFDDMVEILAS-LQKPKKISLKGSDGKFYIMMCK- 895
Query: 2437 SNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLH 2496
DDLR+D + + +NK L+ + +R++ L +RTY VIPL G+IE+V N+ L
Sbjct: 896 PKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLR 955
Query: 2497 DILLNLHCNDEISFD-KARKTMKAAQNHSVEERVLTFSR-ITEKIKPQLRRFFFQSFVHA 2554
IL L+ + K + ++ ++ E++ F + + P +F ++F
Sbjct: 956 PILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDP 1015
Query: 2555 HDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPI 2614
WY SR+ Y +S S+VGY+LGLGDRH NIL D TGE +H+D F++G+ +
Sbjct: 1016 TSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFEV 1075
Query: 2615 PELVPFRLTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKM 2674
PE+VPFRLT ++V+G G G EGLFR CE ++++D++E L+ VL DPL W
Sbjct: 1076 PEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSK 1135
Query: 2675 TPLKKQRLQAKFTGDYDEEEISVSDADFSXXXXXXXXXXXSIRALKGV---ESKLYGDGL 2731
+ TG+ E+ D + L+GV +++ G L
Sbjct: 1136 PVKGHSKAPLNETGEVVNEKAKTHVLDIE-------------QRLQGVIKTRNRVTGLPL 1182
Query: 2732 SVEAIVQELLSSATDKQNLATIYMGWSPF 2760
S+E V L+ ATD+ L +Y+GW+P+
Sbjct: 1183 SIEGHVHYLIQEATDENLLCQMYLGWTPY 1211
>7293222 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2354
Score = 187 bits (476), Expect = 2e-46
Identities = 164/599 (27%), Positives = 263/599 (43%), Gaps = 85/599 (14%)
Query: 2200 FLTTLVHSNSRDAEVVDKFCSLWFSYSTDDIINSKLQKEIG--------TVPSFKFLPWV 2251
+ +L + + + + + SLW +T+ N++ K++ +P+ F
Sbjct: 1802 YAKSLRYGSEHVYQSMPRLISLWLD-TTESSTNTEQVKKMNDLLTNCCTALPTAVFYTVY 1860
Query: 2252 SQMASKLADSVSPFQDTLQLTLKRMLYKLPYETLYPLISMSLQDSESKVIDPVTKSRVEV 2311
SQM S+L V+ L+ + +++ P ++L+ L+ ++ R ++
Sbjct: 1861 SQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRI------KRCKL 1914
Query: 2312 VNKIIAALDMYDSGRYGSQFTRPVQAFCSMSVALA--CHK---IPPKMKFLQLDTLNIGK 2366
V + DS S F + +Q F S++ L +K + K LDT
Sbjct: 1915 V--------LTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKL 1966
Query: 2367 YWLETLPKVHLPL-----PTLPVKITCSQDGRREG----------------RSYISSIDP 2405
++ LP PTLP+ S EG + YIS
Sbjct: 1967 CKQPEFSQILLPFEKYMQPTLPLN---SDSNSSEGSHLPANQSTVNWFPYQQIYISGFQE 2023
Query: 2406 KVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTR 2465
VLI S PK T SDG + VL+K DDLR+DA + + V + L + R
Sbjct: 2024 SVLILRSAAK-PKKLTIRCSDGKDYDVLVK-PKDDLRRDARLMEFNGLVKRYLHQDAPAR 2081
Query: 2466 KQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTMKAAQNH-S 2524
++ L +RTY V+P GL+E++ N S I +NL+ + + A H S
Sbjct: 2082 QRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHES 2141
Query: 2525 VEERVLTFSR-ITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDR 2583
+E + F++ + P + + Q F H WYE+RN Y ++V S+VGY+LGLGDR
Sbjct: 2142 IERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDR 2201
Query: 2584 HLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGFGVAGIEGLFRNNC 2643
H NIL G+ +H+D F+QG+LLP PE+VPFRLT +++ G G+EG FR C
Sbjct: 2202 HGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCC 2261
Query: 2644 ERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAKFTGDYDEEEISVSDADFS 2703
E ++L+ E + L+ +L +D +K AK T D ++D
Sbjct: 2262 EITLRLLKQESKTLMSILRPFVYD-----VGAQTRKGAATAKITKDVQR----IAD---- 2308
Query: 2704 XXXXXXXXXXXSIRALKGVESKLYGDG--LSVEAIVQELLSSATDKQNLATIYMGWSPF 2760
L+G + + LS E V L++ AT NLA++Y+GW F
Sbjct: 2309 --------------RLQGHVKRQQANSIPLSTEGQVNFLINEATKVDNLASMYIGWGAF 2353
>SPBC216.05 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2386
Score = 186 bits (471), Expect = 6e-46
Identities = 160/638 (25%), Positives = 276/638 (43%), Gaps = 85/638 (13%)
Query: 2168 HNRLSLQNHHDKDRYNKISSSRIA--FVSQALHFFLTTLVHSNSRDAEVVDKFCSLWFSY 2225
H+R+ + K N+ S ++ V++ ++ F +L + + E + K +LW +
Sbjct: 1790 HHRVLMYEEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDF 1849
Query: 2226 STDDI-------------------------INSKLQKEIGTVPSFKFLPWVSQMASKLAD 2260
+++ +NS + + +P + FL +SQM S++
Sbjct: 1850 GAEELRLSKDDGEKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFLVALSQMISRVCH 1909
Query: 2261 SVSPFQDTLQLTLKRMLYKLPYETLYPLISMSLQDSESKVIDPVTKSRVEVVNK----II 2316
+ L+ + ++ P ETL+ L++ S+ + + KS + V++ +
Sbjct: 1910 PNNKVYKILEHIIANVVASYPGETLWQLMATIKSTSQKRSLRG--KSILNVLHSRKLSMS 1967
Query: 2317 AALDMYDSGRYGSQFTRPVQAFCSMSVALACHKIPPKMKFL-----QLDTLNIGKYWLET 2371
+ +D+ + T + C+ + K+ K F +D + K +L+
Sbjct: 1968 SKVDIKALSQSAILITEKLINLCNTRINSKSVKMSLKDHFRLSFDDPVDLVIPAKSFLDI 2027
Query: 2372 LPKVHLPLPTLPVKITCSQDGRREGRSYISSIDPKVLISS------SGLSLPKIATFTVS 2425
TLP K D R P +L + L P+ +
Sbjct: 2028 ---------TLPAK-----DANRASHYPFPKTQPTLLKFEDEVDIMNSLQKPRKVYVRGT 2073
Query: 2426 DGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGL 2485
DG + L K DDLR+DA + + + KIL+ ++ ++NL +RTY VIPL G
Sbjct: 2074 DGNLYPFLCK-PKDDLRKDARLMEFNNLICKILRKDQEANRRNLCIRTYVVIPLNEECGF 2132
Query: 2486 IEFVANSMSLHDILLNLHC--NDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQL 2543
IE+V ++ +ILL + N IS+ + + + A S + +I K P
Sbjct: 2133 IEWVNHTRPFREILLKSYRQKNIPISYQEIKVDLDFALR-SPNPGDIFEKKILPKFPPVF 2191
Query: 2544 RRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLG 2603
+F +SF ++W SR Y +++ SIVGY+LGLGDRH NIL D TGE IH+D
Sbjct: 2192 YEWFVESFPEPNNWVTSRQNYCRTLAVMSIVGYVLGLGDRHGENILFDEFTGEAIHVDFN 2251
Query: 2604 VAFDQGKLLPIPELVPFRLTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNV 2663
FD+G PE VPFRLT ++VD G G EG FR E ++L+ ++ L+ VL
Sbjct: 2252 CLFDKGLTFEKPEKVPFRLTHNMVDAMGPTGYEGGFRKASEITMRLLRSNQDTLMSVLES 2311
Query: 2664 LKWDPLYSWKMTPLKKQRLQAKFTGDYDEEEISVSDADFSXXXXXXXXXXXSIRALKGVE 2723
DPL W +++ +K+ + E + + F
Sbjct: 2312 FLHDPLVEW-----NRKKSSSKYPNNEANEVLDIIRKKFQGFMPGETI------------ 2354
Query: 2724 SKLYGDGLSVEAIVQELLSSATDKQNLATIYMGWSPFY 2761
LS+E +QEL+ SA + +NL +Y+GW+ ++
Sbjct: 2355 ------PLSIEGQIQELIKSAVNPKNLVEMYIGWAAYF 2386
>At5g40820 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2810
Score = 176 bits (446), Expect = 5e-43
Identities = 182/798 (22%), Positives = 328/798 (40%), Gaps = 135/798 (16%)
Query: 2017 VESARMLWANKESAMAINMLEDLLQTNLTAVNVENVSLADVQDILMPDAVVDSQLVEWSS 2076
+E A++LW K S AI L+ L + MP+ VVDS ++ SS
Sbjct: 1986 MEKAKLLWITKRSDSAIIELQQSL-------------------LNMPEGVVDSTVI--SS 2024
Query: 2077 FSRHRSPDVIFNDHILYYERDVLNINEPNLRSSICYTYAEFCYKQSQKVDEGELLYLKQK 2136
+ L + PN ++ T + +K+ + V + LLY K
Sbjct: 2025 INS-------------------LLMAPPNPEPTVRNTQS---FKEKKDVAKTLLLYSKWI 2062
Query: 2137 IAKASNQLQEISSIYKNPKLRDAERK---EAKRHHNRLSLQNHHDKDRYNKISS--SRIA 2191
Q +++ ++Y K K ++++ L + + + SS S+
Sbjct: 2063 HHSGQKQKKDVLNLYTQVKELLPWEKGYFHLAKYYDELYVDARKCQQESSVFSSAGSKKG 2122
Query: 2192 FVSQALH-------------FFLTTLVHSNSRDA-EVVDKFCSLWFSYSTD--------- 2228
VS L +F +HS ++ + + + +LWF + T
Sbjct: 2123 SVSSNLSTEKAGWDYLFKGMYFYAKALHSGHKNLFQALPRLLTLWFDFGTIYKTSGSAGN 2182
Query: 2229 --------DIINSKLQKEIGTVPSFKFLPWVSQMASKLADSVSPFQDTLQLTLKRMLYKL 2280
+I S ++ + +P++++L + Q+ S++ + ++ + +L++
Sbjct: 2183 KELKSTHMKVIMSLMRGCLKDLPTYQWLTVLPQLVSRICHQNADTVLMVKNIITSVLHQF 2242
Query: 2281 PYETLYPLISMSLQDSESKVIDPVTKSRVEVVNKIIAALDMYDSGR-YGSQFTRPVQAFC 2339
P + L+ + ++S + ++ E++ + D G QF F
Sbjct: 2243 PQQGLWIMAAVS-----KSTVPARREAAAEIIQGARKGFNQSDRGHNLFIQFASLTDHF- 2296
Query: 2340 SMSVALACHKIPPKMKFLQLDTLNIGKYWLETLPKVHLPLPTLPVKITCSQDGRREGRSY 2399
+ L H P+ K + + T + L + +L + + E S
Sbjct: 2297 ---IKLCFHGGQPRSKVINIATEFSALKRMMPLDIIMPIQQSLTISLPAFHMNNNERHSA 2353
Query: 2400 ----------ISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQ 2449
IS I + I SS L PK +DG + L K DDLR+DA M +
Sbjct: 2354 SVFSGSDLPTISGIADEAEILSS-LQRPKKIILLGNDGIEYPFLCK-PKDDLRKDARMME 2411
Query: 2450 VFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCN-DEI 2508
+N++L +R++ L +RT+ V PL GL+E+V ++ L IL +++ + +
Sbjct: 2412 FTAMINRLLSKYPESRRRKLYIRTFAVAPLTEDCGLVEWVPHTRGLRHILQDIYISCGKF 2471
Query: 2509 SFDKARKTMKAAQNHSV--EERVLTFSRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTK 2566
K +K + +E + ++I P ++F +F W+ SR Y
Sbjct: 2472 DRQKTNPQIKRIYDQCAVKKEYEMLKTKILPMFPPVFHKWFLTTFSEPAAWFRSRVAYAH 2531
Query: 2567 SVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDI 2626
+ S+VG+++GLGDRH NIL D +G+ +H+D FD+G L PELVPFRLT+++
Sbjct: 2532 TTAVWSMVGHIVGLGDRHGENILFDSTSGDCVHVDFSCLFDKGLQLEKPELVPFRLTQNM 2591
Query: 2627 VDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAKF 2686
+DG G+ G EG+F CE VL+ +E L+ +L DPL W
Sbjct: 2592 IDGLGITGYEGIFMRVCEITLTVLRTHRETLMSILETFIHDPLVEW-------------- 2637
Query: 2687 TGDYDEEEISVSDADFSXXXXXXXXXXXSIRALKGVESKL----YGDGLSVEAIVQELLS 2742
T + + V + + RA+ +E++L G L VE + L++
Sbjct: 2638 TKSHKSSGVEVQNP-------------HAQRAISSIEARLQGVVVGVPLPVEGQARRLIA 2684
Query: 2743 SATDKQNLATIYMGWSPF 2760
A +NL +Y+ W P+
Sbjct: 2685 DAVSLENLGKMYIWWMPW 2702
>YKL203c [L] KOG0891 DNA-dependent protein kinase
Length = 2473
Score = 173 bits (439), Expect = 3e-42
Identities = 122/387 (31%), Positives = 191/387 (48%), Gaps = 31/387 (8%)
Query: 2400 ISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILK 2459
IS +P + SS P+ SDG ++ +LKG ++D+RQD+++ Q+F VN +L+
Sbjct: 2093 ISKFEPVFSVISSK-QRPRKFCIKGSDGKDYKYVLKG-HEDIRQDSLVMQLFGLVNTLLQ 2150
Query: 2460 ANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTMKA 2519
+ +++L ++ Y IPL P++GL+ +V NS + H ++ +I + M
Sbjct: 2151 NDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQ 2210
Query: 2520 A----QNHSVEERVLTFSRITEKIKPQ-LRRFFFQSFVHAHDWYESRNRYTKSVVTSSIV 2574
N ++ ++V F+ + Q L + + + W E R YT+S+ S+
Sbjct: 2211 MAPDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMT 2270
Query: 2575 GYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLP-IPELVPFRLTRDIVDGFGVA 2633
GY+LGLGDRH +N+++D TG+ IHID G F+ L PE VPFRLTR + V+
Sbjct: 2271 GYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVS 2330
Query: 2634 GIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKM-TPLKKQRLQAKF------ 2686
GIEG FR CE V KVL+D K L+ +L +DPL +W P KK +
Sbjct: 2331 GIEGSFRITCENVMKVLRDNKGSLMAILEAFAFDPLINWGFDLPTKKIEEETGIQLPVMN 2390
Query: 2687 ------TGDYDEEEISVSDADFSXXXXXXXXXXXSIRALKGVESKLYG------DGLSVE 2734
G EEE+ + + ++ LK + KL G + L V
Sbjct: 2391 ANELLSNGAITEEEVQRVENEHK----NAIRNARAMLVLKRITDKLTGNDIRRFNDLDVP 2446
Query: 2735 AIVQELLSSATDKQNLATIYMGWSPFY 2761
V +L+ AT +NL Y+GW PF+
Sbjct: 2447 EQVDKLIQQATSVENLCQHYIGWCPFW 2473
>YJR066w [L] KOG0891 DNA-dependent protein kinase
Length = 2470
Score = 173 bits (438), Expect = 4e-42
Identities = 122/385 (31%), Positives = 195/385 (49%), Gaps = 27/385 (7%)
Query: 2400 ISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILK 2459
I+ +P + SS P+ + SDG ++ +LKG ++D+RQD+++ Q+F VN +LK
Sbjct: 2090 IAKFEPLFSVISSK-QRPRKFSIKGSDGKDYKYVLKG-HEDIRQDSLVMQLFGLVNTLLK 2147
Query: 2460 ANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTMKA 2519
+ K++L ++ Y IPL P++GL+ +V NS + H ++ +I + M
Sbjct: 2148 NDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHRDAKKIPLNIEHWVMLQ 2207
Query: 2520 A----QNHSVEERVLTFSRITEKIKPQ-LRRFFFQSFVHAHDWYESRNRYTKSVVTSSIV 2574
+N ++ +++ F+ + K Q L + + + W E R YT+S+ S+
Sbjct: 2208 MAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRSSETWLERRTTYTRSLAVMSMT 2267
Query: 2575 GYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLP-IPELVPFRLTRDIVDGFGVA 2633
GY+LGLGDRH +N+++D TG+ IHID G F+ L PE VPFRLTR + V+
Sbjct: 2268 GYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPEKVPFRLTRMLTYAMEVS 2327
Query: 2634 GIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAKFTGD---- 2689
GIEG FR CE V +VL+D KE L+ +L DPL W L Q+L + TG
Sbjct: 2328 GIEGSFRITCENVMRVLRDNKESLMAILEAFALDPLIHWGF-DLPPQKLTEQ-TGIPLPL 2385
Query: 2690 ------YDEEEISVSD-ADFSXXXXXXXXXXXSIRALKGVESKLYGDG------LSVEAI 2736
+ I+V + A+ ++ L+ + KL G+ L V
Sbjct: 2386 INPSELLRKGAITVEEAANMEAEQQNETKNARAMLVLRRITDKLTGNDIKRFNELDVPEQ 2445
Query: 2737 VQELLSSATDKQNLATIYMGWSPFY 2761
V +L+ AT + L Y+GW PF+
Sbjct: 2446 VDKLIQQATSIERLCQHYIGWCPFW 2470
>7297995 [L] KOG0891 DNA-dependent protein kinase
Length = 2470
Score = 172 bits (435), Expect = 9e-42
Identities = 115/377 (30%), Positives = 184/377 (48%), Gaps = 44/377 (11%)
Query: 2425 SDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAG 2484
S+G + LLKG ++DLRQD + Q+F VN +L + T ++NL+++ Y VIPL +G
Sbjct: 2098 SNGKDYMYLLKG-HEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSG 2156
Query: 2485 LIEFVANSMSLHDILLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIK---- 2540
LI +V + +LH ++ + ++ ++ +TM N + + LT + E +
Sbjct: 2157 LIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTML---NFAPDYDHLTLMQKVEVFEHALG 2213
Query: 2541 ----PQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGE 2596
L + + + W+E RN YT+S+ S+VGY+LGLGDRH +N+++D +G+
Sbjct: 2214 QTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGK 2273
Query: 2597 PIHIDLGVAFDQGKLL-PIPELVPFRLTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKE 2655
+HID G F+ PE +PFRLTR ++ V GIEG +R CE V VL+ K+
Sbjct: 2274 ILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKD 2333
Query: 2656 RLLCVLNVLKWDPLYSWKMTPLKKQRLQAKF----------TGDYDEEEISVSDA----- 2700
L+ VL +DPL +W++ + K+ A +G D SV D+
Sbjct: 2334 SLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAK 2393
Query: 2701 ----------DFSXXXXXXXXXXXSIRALKGVESKLYGDGLSVEAIVQE------LLSSA 2744
+ + +K V+ KL G E V E L+ A
Sbjct: 2394 SKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQA 2453
Query: 2745 TDKQNLATIYMGWSPFY 2761
T+ +NL Y+GW PF+
Sbjct: 2454 TNNENLCQCYIGWCPFW 2470
>SPBC216.07c [L] KOG0891 DNA-dependent protein kinase
Length = 1973
Score = 171 bits (433), Expect = 2e-41
Identities = 112/376 (29%), Positives = 188/376 (49%), Gaps = 40/376 (10%)
Query: 2417 PKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEV 2476
P+ + SDG ++ +LKG ++D+RQD + Q+F N +L A+ T K+ LS++ Y V
Sbjct: 1607 PRRLSIKGSDGKDYQYVLKG-HEDIRQDERVMQLFGLCNNLLLADPETFKRLLSIQRYPV 1665
Query: 2477 IPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRIT 2536
IPL P +GL+ +V +S +LH ++ + + ++RK + ++ + + + R+T
Sbjct: 1666 IPLSPDSGLLGWVLDSDTLHVLIRD--------YRESRKILLNIEHRLIIQMAPDYDRLT 1717
Query: 2537 --EKIK-----------PQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDR 2583
+K++ L R + + W R Y++++ S+VGY+LGLGDR
Sbjct: 1718 LLQKVEVFEYALLSTTGQDLYRVLWLKSRSSEAWLNRRTNYSRTLAVMSMVGYILGLGDR 1777
Query: 2584 HLNNILIDIKTGEPIHIDLGVAFDQGKLLP-IPELVPFRLTRDIVDGFGVAGIEGLFRNN 2642
H +N+++D TG IHID G F+ PE +PFRLTR +V+ V+GIEG FR
Sbjct: 1778 HPSNLMLDRYTGNIIHIDFGDCFEVAMHREKFPEKIPFRLTRMLVNAMEVSGIEGTFRIT 1837
Query: 2643 CERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAKFTGD-----------YD 2691
CE V +VL+ KE ++ VL +DPL +W++ P + K + +
Sbjct: 1838 CEHVMRVLRTNKESVMAVLEAFVYDPLINWRLAPAYSPSIDEKQSNEPNTLLGETIDGLH 1897
Query: 2692 EEEISVSDADFSXXXXXXXXXXXSIRALKGVESKLYG------DGLSVEAIVQELLSSAT 2745
+ ++ +I L V +KL G L V + V++L+ AT
Sbjct: 1898 RKRLNEEGITLEERQKPEILNQRAITVLNRVSNKLTGRDFKPQQQLDVPSQVEKLILQAT 1957
Query: 2746 DKQNLATIYMGWSPFY 2761
+NL Y+GW F+
Sbjct: 1958 SIENLCLCYIGWCSFW 1973
>SPBC30D10.10c [L] KOG0891 DNA-dependent protein kinase
Length = 2335
Score = 168 bits (426), Expect = 1e-40
Identities = 120/376 (31%), Positives = 190/376 (49%), Gaps = 39/376 (10%)
Query: 2417 PKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEV 2476
P+ T SDG ++ +LKG ++DLRQD + Q+F N +L + T K+ L++ Y V
Sbjct: 1968 PRRLTIHGSDGKDYQYVLKG-HEDLRQDERVMQLFGLCNTLLTTDSETFKRRLNIERYTV 2026
Query: 2477 IPLGPRAGLIEFVANSMSLH----------DILLNLHCNDEISFDKARKTMKAAQNHSVE 2526
IPL P +GL+ +V +S +LH +ILLNL + ++ Q V
Sbjct: 2027 IPLSPNSGLLGWVPHSDTLHFLIKEFRSKRNILLNLEHRMMLQMAPDCDSLTLLQKLEVF 2086
Query: 2527 ERVLTFSRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLN 2586
E V+ + + L + + W + R YT+S+ S+VGY+LGLGDRH +
Sbjct: 2087 EYVMANTDGYD-----LYHVLWLKSRSSEAWLDRRTSYTQSLAVMSMVGYILGLGDRHPS 2141
Query: 2587 NILIDIKTGEPIHIDLGVAFDQGKLLP-IPELVPFRLTRDIVDGFGVAGIEGLFRNNCER 2645
N+++D +G+ IHID G F+ PE +PFRLTR +++ V+GI+G ++ CE
Sbjct: 2142 NLMMDRYSGKIIHIDFGDCFEVAMHREKFPEKIPFRLTRMLINAMEVSGIQGTYKITCEL 2201
Query: 2646 VFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAKFT-----GDYDEEEISVS-- 2698
V +VL+ E L+ VL +DPL +W++ + K A T +E+ S +
Sbjct: 2202 VMRVLRSNTESLMAVLEAFVYDPLINWRL--MTKSSFGASTTLRPTSSSVEEKGRSYTHR 2259
Query: 2699 --DADFSXXXXXXXXXX-----XSIRALKGVESKLYG------DGLSVEAIVQELLSSAT 2745
AD++ SI+ LK V +KL G + L V+A V++L+ AT
Sbjct: 2260 ARHADYAALSETNGVNAEGLNERSIQVLKRVSNKLTGKDFDLKEQLPVKAQVEKLIQQAT 2319
Query: 2746 DKQNLATIYMGWSPFY 2761
+NL Y+GW F+
Sbjct: 2320 APENLCRCYVGWCSFW 2335
>YBR136w [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2368
Score = 168 bits (425), Expect = 1e-40
Identities = 170/763 (22%), Positives = 328/763 (42%), Gaps = 131/763 (17%)
Query: 2040 LQTNLTAVNVENVSLADVQDILMPDAVVDSQLVEWSSFSRHRSPDVIFNDHILYYERDVL 2099
L N +++ + SL + +P A ++ + W R+ ++ H Y E +
Sbjct: 1696 LARNNARLDIASESLMHCLERRLPQAELEFAEILWKQGENDRALKIVQEIHEKYQENSSV 1755
Query: 2100 NINEPNLRSSICYTYAEFCYKQSQKVDEGELLYLKQKIAKASNQLQEISSIYKNPKL--- 2156
N + R+++ + E+ + E +I K + +I S + P
Sbjct: 1756 NARD---RAAVLLKFTEWLDLSNNSASE--------QIIKQYQDIFQIDSKWDKPYYSIG 1804
Query: 2157 ----RDAERKEAKRHHNRLSLQNHHDKDRYNKISSSRIAFVSQALHFFLTTLVHSNSRDA 2212
R ERK+A+ + I++ R + +A+ +FL + ++
Sbjct: 1805 LYYSRLLERKKAEGY-----------------ITNGRFEY--RAISYFLLAFEKNTAKVR 1845
Query: 2213 EVVDKFCSLWF------------------SYSTDDIINSKLQKEIGTVPSFKFLPWVSQM 2254
E + K + W S +T+DI S +++ + P++ + ++Q+
Sbjct: 1846 ENLPKVITFWLDIAAASISEAPGNRKEMLSKATEDIC-SHVEEALQHCPTYIWYFVLTQL 1904
Query: 2255 ASKLADSVSPFQDTLQLTLKRMLYKLPYETLYPLISMSLQDSESKVIDP---VTKSRVEV 2311
S+L S + L + + P L+ + ++ +S +V+ + K R
Sbjct: 1905 LSRLLHSHQSSAQIIMHILLSLAVEYPSHILWYITALVNSNSSKRVLRGKHILEKYRQHS 1964
Query: 2312 VNK---IIAALDMYDSGRYGSQFTRPVQAFCSMSVALACHKIPPKMKFLQLDTLNIGKYW 2368
N + +ALD+ T+ + C V + ++ +N+
Sbjct: 1965 QNPHDLVSSALDL----------TKALTRVCLQDVKSITSRSGKSLEKDFKFDMNVAPSA 2014
Query: 2369 LETLPKVHLPLPTLPVKITCSQDGRREGRSYISSI----DPKVLISSSGLSLPKIATFTV 2424
+ + +L + + P++ S G + R +S I KV S L PK
Sbjct: 2015 MVVPVRKNLDIIS-PLESN-SMRGYQPFRPVVSIIRFGSSYKVF---SSLKKPKQLNIIG 2069
Query: 2425 SDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAG 2484
SDG + ++ K +D+RQD Q ++ +L + +RK++L + Y V+ L G
Sbjct: 2070 SDGNIYGIMCK--KEDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCG 2127
Query: 2485 LIEFVANSMSLHDILLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLR 2544
++E V N ++L IL + + +I + + Q+ +V+ ++ + +K P L
Sbjct: 2128 ILEMVPNVVTLRSILSTKYESLKIKYS-LKSLHDRWQHTAVDGKLEFYMEQVDKFPPILY 2186
Query: 2545 RFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGV 2604
++F ++F +W+ +RN Y +S ++VG++LGLGDRH NIL+DI+TG+ +H+D
Sbjct: 2187 QWFLENFPDPINWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDC 2246
Query: 2605 AFDQGKLLPIPELVPFRLTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVL 2664
F++GK LP+PE+VPFRLT +++D G+ G EG F+ + E +++ + L+ V+ +
Sbjct: 2247 LFEKGKRLPVPEIVPFRLTPNLLDALGIIGTEGTFKKSSEVTLALMRKNEVALMNVIETI 2306
Query: 2665 KWDPLYSWKMTPLKKQRLQAKFTGDYDEEEISVSDADFSXXXXXXXXXXXSIRALKGVES 2724
+D + D S +ALK + +
Sbjct: 2307 MYD------------------------------RNMDHSIQ-----------KALKVLRN 2325
Query: 2725 KLYG----DG--LSVEAIVQELLSSATDKQNLATIYMGWSPFY 2761
K+ G DG LSV + L+ AT + NL+ +Y+GW PF+
Sbjct: 2326 KIRGIDPQDGLVLSVAGQTETLIQEATSEDNLSKMYIGWLPFW 2368
>CE28813 [L] KOG0891 DNA-dependent protein kinase
Length = 687
Score = 167 bits (422), Expect = 3e-40
Identities = 117/365 (32%), Positives = 181/365 (49%), Gaps = 32/365 (8%)
Query: 2417 PKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEV 2476
P+ S+G ++ LLKG ++D RQD + Q+F VN +L N T ++NL+++ Y +
Sbjct: 335 PRKMVIRGSNGLDYQFLLKG-HEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSI 393
Query: 2477 IPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTM----KAAQNHSVEERVLTF 2532
+ L +GLI +V N +LH ++ E KA+ + K Q S+E LT
Sbjct: 394 VALSKDSGLIGWVPNCDTLHTLV------KEYREKKAKIPLSIEHKTLQKLSLETEHLTL 447
Query: 2533 --------SRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRH 2584
S ++ LR + + W++ R YT+SV S+VGY+LGLGDRH
Sbjct: 448 MQKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRH 507
Query: 2585 LNNILIDIKTGEPIHIDLGVAFDQGKLL-PIPELVPFRLTRDIVDGFGVAGIEGLFRNNC 2643
+N+++D TG+ +HID G F+ L PE VPFRLTR +++ V G++G++
Sbjct: 508 PSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINAMEVTGLDGVYNYTA 567
Query: 2644 ERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTP-LKKQRLQAKFTGDYDEEEISVSDADF 2702
ERV K+L+ +E LL VL +DP+ +W++ +KK K TG +++ A
Sbjct: 568 ERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKDPKTRKDTGGRQ----NMAGAVL 623
Query: 2703 SXXXXXXXXXXXSIRALKGVESKLYGDG------LSVEAIVQELLSSATDKQNLATIYMG 2756
R L G E ++ DG L V + L AT NL Y+G
Sbjct: 624 PSSSTTDSIMETIKRKLDGTEF-VHTDGSTPPEPLQVTEQLAMLTEQATSPLNLCQSYIG 682
Query: 2757 WSPFY 2761
W PF+
Sbjct: 683 WCPFW 687
>CE07705 [L] KOG0891 DNA-dependent protein kinase
Length = 2697
Score = 167 bits (422), Expect = 3e-40
Identities = 117/365 (32%), Positives = 181/365 (49%), Gaps = 32/365 (8%)
Query: 2417 PKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEV 2476
P+ S+G ++ LLKG ++D RQD + Q+F VN +L N T ++NL+++ Y +
Sbjct: 2345 PRKMVIRGSNGLDYQFLLKG-HEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSI 2403
Query: 2477 IPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTM----KAAQNHSVEERVLTF 2532
+ L +GLI +V N +LH ++ E KA+ + K Q S+E LT
Sbjct: 2404 VALSKDSGLIGWVPNCDTLHTLV------KEYREKKAKIPLSIEHKTLQKLSLETEHLTL 2457
Query: 2533 --------SRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRH 2584
S ++ LR + + W++ R YT+SV S+VGY+LGLGDRH
Sbjct: 2458 MQKLQLFESALSVTQGEDLRHVLWLKSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRH 2517
Query: 2585 LNNILIDIKTGEPIHIDLGVAFDQGKLL-PIPELVPFRLTRDIVDGFGVAGIEGLFRNNC 2643
+N+++D TG+ +HID G F+ L PE VPFRLTR +++ V G++G++
Sbjct: 2518 PSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINAMEVTGLDGVYNYTA 2577
Query: 2644 ERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTP-LKKQRLQAKFTGDYDEEEISVSDADF 2702
ERV K+L+ +E LL VL +DP+ +W++ +KK K TG +++ A
Sbjct: 2578 ERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKDPKTRKDTGGRQ----NMAGAVL 2633
Query: 2703 SXXXXXXXXXXXSIRALKGVESKLYGDG------LSVEAIVQELLSSATDKQNLATIYMG 2756
R L G E ++ DG L V + L AT NL Y+G
Sbjct: 2634 PSSSTTDSIMETIKRKLDGTEF-VHTDGSTPPEPLQVTEQLAMLTEQATSPLNLCQSYIG 2692
Query: 2757 WSPFY 2761
W PF+
Sbjct: 2693 WCPFW 2697
>ECU02g1130 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 1935
Score = 166 bits (420), Expect = 5e-40
Identities = 166/650 (25%), Positives = 277/650 (42%), Gaps = 108/650 (16%)
Query: 2129 ELLYLKQKIAKASNQLQEI-------SSIYKNPKLRDAERKEAKRHHNRLSLQNHHDKDR 2181
EL L+ KI A L+++ S +YK +R +E + K + +L D +
Sbjct: 1375 ELNVLQGKIGDAKTSLKKVLEIFPKTSMLYKKALIRYSELLDTKTAYTS-ALSILKDSGK 1433
Query: 2182 YNKISSSRIAFVS--QALHFFLTTLVHSNSRDAEVVDKFCSLWFSYSTDDIINSK----- 2234
+ + + +A+ ++ +++H N E V + L+ IN+
Sbjct: 1434 LFLLGAKKFESTEPVKAMEMYINSVIHDNQCSDEAVPRIFHLFSEMMPPGDINAGAVLLK 1493
Query: 2235 --LQKEIGTVPSFKFLPWVSQMASKLADSVSPFQDTLQLTLKRMLYKLPYETLY-PLISM 2291
L+ I +P P+ +Q+ S+L+ + + + ++ P +T + LI M
Sbjct: 1494 KFLESSISLLP-----PYYNQILSRLSHPNQDVANVVSRIVFELMENYPSKTFWRSLIMM 1548
Query: 2292 SLQDSESKVIDPVTKSRVEVVNKIIAALDMYDSGRYGSQFTRPVQAFCSMSVALACHKIP 2351
+ Q P T+ R+E I++ L + D+ S R +S L C
Sbjct: 1549 NSQV-------PSTRKRME---GIVSGLTL-DNKVALSNVKR-------ISEELTCISRS 1590
Query: 2352 PKMKF-LQLDTLNIGKYWLETLPKVHLPLPTLPVKITCSQDGRREGRSYISSIDPKVLIS 2410
K + ++ D K + P +T + IS + +V +
Sbjct: 1591 KKNELTMEEDFPAFAKMF--------------PAGVTVPNT-----KVLISGVRNEVKVF 1631
Query: 2411 SSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLS 2470
+S L PK F SDG + L K + DDLR+D+ + +N ILK +++RK
Sbjct: 1632 NS-LQRPKRICFVGSDGKNYYWLCK-NQDDLRKDSRFMDLNLIINSILK-KQSSRKY--- 1685
Query: 2471 VRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTMKAAQNHSVEERVL 2530
+RTY VIP +G+IE++ SL I + D IS + + N + R
Sbjct: 1686 IRTYAVIPFSHESGIIEWIGGLSSLKAICDTYYARDGISISET--ACRFVHNKKIGMR-- 1741
Query: 2531 TFSRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILI 2590
+ R+ K P+ +F SF H W +RN YT++ +IVG+ +GLGDRH NIL
Sbjct: 1742 EWHRVASKFHPKFHLWFHDSFPHPFSWLVARNNYTQTYAIMNIVGWFMGLGDRHAENILF 1801
Query: 2591 DIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGFGVAGIEGLFRNNCERVFKVL 2650
D TG+ +H+DL F +GK L +PE VP+RLT++IVD FGV G+EG + + +
Sbjct: 1802 DSNTGDTVHVDLNCIFGKGKELQVPERVPYRLTQNIVDAFGVLGLEGSYNTSLCTTLDLF 1861
Query: 2651 QDEKERLLCVLNVLKWDPLYSWKMTPLKKQRLQAKFTGDYDEEEISVSDADFSXXXXXXX 2710
K L+ L +DPL+ W+ +K K
Sbjct: 1862 LKNKNILVSNLLSFVYDPLFEWR----RKSATTPK------------------------- 1892
Query: 2711 XXXXSIRALKGVESKLYGDGLSVEAIVQELLSSATDKQNLATIYMGWSPF 2760
+ ++ + K+ D L + L AT+ +NL +Y+GW PF
Sbjct: 1893 ------KIIEDLWHKM--DDLDACSKCDVLNEEATNDENLCMMYIGWLPF 1934
>CE22176 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 759
Score = 165 bits (418), Expect = 8e-40
Identities = 142/473 (30%), Positives = 223/473 (47%), Gaps = 62/473 (13%)
Query: 2223 FSYSTDDIINSKLQKEIGT-VPSFKFLPWVSQMASKLADSVSPFQDTLQLT--LKRMLYK 2279
+ Y TD + + L++ + +PS ++ S +ASK S+ Q T L+ L ++Y
Sbjct: 135 YKYETDVGVIALLKEHTKSKLPSKLWISATSHIASKCF-SIEKSQITRHLSQILCHLIYD 193
Query: 2280 LPYETLYPLISMSLQDSESKVIDPVTKSRVEVVNKIIAALDMYDSGRYGS---QFTRPVQ 2336
PY L+ ++ + + SKV K ++ + A D DS + Q
Sbjct: 194 YPYHVLHTILMYDDEKNASKV-----KGFLKTI--FDARADQRDSSKLKEIVITIREAHQ 246
Query: 2337 AFCSMS-------VALACHKIPPKMKFLQLDTLNIGKYWLETLPKVHLPLPTLPVKITCS 2389
A+ ++ V + +I K + L I K L LP+PT+ KI C
Sbjct: 247 AYREIAMLDVRGNVRIQRVEINGKTMYRWPHDLKIFKCKLR-----QLPIPTISQKIGCP 301
Query: 2390 QDGRREGRSYISSID-------PKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLR 2442
D S+ D V + G+S PKI SDG ++ + K DD+R
Sbjct: 302 GD--------YSTTDLITWKRWKDVFTIADGISTPKIWEIEGSDGKWYKTVWK--KDDVR 351
Query: 2443 QDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLN- 2501
QD ++EQ+F N +L + +RTY V+PL G+IEF ++SL +++
Sbjct: 352 QDVLVEQMFDVTNNML--------EKAMLRTYNVVPLDTECGVIEFCGGTVSLKEVMCGV 403
Query: 2502 -----LHC---NDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVH 2553
LH ++E+S K M+ Q S E R F I ++ P R FF+ +F
Sbjct: 404 TREGGLHREFNSEEVSASKVSSMMRQVQTESTETRRQVFVEICQQYSPVFRHFFYTNFST 463
Query: 2554 AHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGK-LL 2612
A W + Y +S+ T SIV Y++GLGDRH +NIL D K +HIDLG+ + K L
Sbjct: 464 AQIWRQKIINYRQSLATWSIVCYIVGLGDRHASNILFDQKLCTFVHIDLGMILEYSKRTL 523
Query: 2613 PIPELVPFRLTRDIVDGFGVAGIE-GLFRNNCERVFKVLQDEKERLLCVLNVL 2664
P+PE VPFR+TRD++D + GIE G C ++ + L++ + +L V + L
Sbjct: 524 PVPEQVPFRITRDVLDPILIEGIENGQLAEECTQIMEKLKENGKVILGVASAL 576
>Hs4826730 [L] KOG0891 DNA-dependent protein kinase
Length = 2549
Score = 163 bits (413), Expect = 3e-39
Identities = 117/399 (29%), Positives = 195/399 (48%), Gaps = 39/399 (9%)
Query: 2400 ISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILK 2459
I SI P + + +S P+ T S+G LLKG ++DLRQD + Q+F VN +L
Sbjct: 2153 IQSIAPSLQVITSK-QRPRKLTLMGSNGHEFVFLLKG-HEDLRQDERVMQLFGLVNTLLA 2210
Query: 2460 ANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTM-K 2518
+ T+ ++NLS++ Y VIPL +GLI +V + +LH ++ + +I + + M +
Sbjct: 2211 NDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLR 2270
Query: 2519 AAQNH---SVEERVLTFSR-ITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIV 2574
A ++ ++ ++V F + L + + + W++ R YT+S+ S+V
Sbjct: 2271 MAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMV 2330
Query: 2575 GYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLL-PIPELVPFRLTRDIVDGFGVA 2633
GY+LGLGDRH +N+++D +G+ +HID G F+ PE +PFRLTR + + V
Sbjct: 2331 GYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVT 2390
Query: 2634 GIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKM--TPLKKQRLQAKFTGDY- 2690
G++G +R C V +VL++ K+ ++ VL +DPL +W++ T K + T Y
Sbjct: 2391 GLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYS 2450
Query: 2691 --------DEEEI--------------SVSDADFSXXXXXXXXXXXSIRALKGVESKLYG 2728
D E+ S+ +I+ + V KL G
Sbjct: 2451 AGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTG 2510
Query: 2729 ------DGLSVEAIVQELLSSATDKQNLATIYMGWSPFY 2761
D L V V+ L+ AT +NL Y+GW PF+
Sbjct: 2511 RDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW 2549
>Hs18765739 [L] KOG0891 DNA-dependent protein kinase
Length = 3657
Score = 149 bits (376), Expect = 6e-35
Identities = 93/290 (32%), Positives = 139/290 (47%), Gaps = 35/290 (12%)
Query: 2417 PKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEV 2476
PK F SDG + L KG +DL D + Q VN + R Y V
Sbjct: 2133 PKKLLFLGSDGKSYPYLFKGL-EDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSV 2191
Query: 2477 IPLGPRAGLIEFVANSMSLHDILLNLHCNDE-ISFDKARKTMKAAQNHSVEERV--LTFS 2533
PLG R+GLI++V + L + + + KA+ + + QN + R L +S
Sbjct: 2192 TPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYS 2251
Query: 2534 RITEKIKPQ-------------------------------LRRFFFQSFVHAHDWYESRN 2562
+I +K L + + S +W+
Sbjct: 2252 KIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQ 2311
Query: 2563 RYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRL 2622
Y +S S+VGY++GLGDRHL+N+LID+ TGE +HID V F++GK L +PE VPFR+
Sbjct: 2312 SYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRM 2371
Query: 2623 TRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSW 2672
T++I GV G+EG+FR +CE+V +++ +E LL +L +DPL W
Sbjct: 2372 TQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDW 2421
>Hs14719394 [L] KOG0891 DNA-dependent protein kinase
Length = 3031
Score = 149 bits (376), Expect = 6e-35
Identities = 93/290 (32%), Positives = 139/290 (47%), Gaps = 35/290 (12%)
Query: 2417 PKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEV 2476
PK F SDG + L KG +DL D + Q VN + R Y V
Sbjct: 1507 PKKLLFLGSDGKSYPYLFKGL-EDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSV 1565
Query: 2477 IPLGPRAGLIEFVANSMSLHDILLNLHCNDE-ISFDKARKTMKAAQNHSVEERV--LTFS 2533
PLG R+GLI++V + L + + + KA+ + + QN + R L +S
Sbjct: 1566 TPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYS 1625
Query: 2534 RITEKIKPQ-------------------------------LRRFFFQSFVHAHDWYESRN 2562
+I +K L + + S +W+
Sbjct: 1626 KIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQ 1685
Query: 2563 RYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRL 2622
Y +S S+VGY++GLGDRHL+N+LID+ TGE +HID V F++GK L +PE VPFR+
Sbjct: 1686 SYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRM 1745
Query: 2623 TRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSW 2672
T++I GV G+EG+FR +CE+V +++ +E LL +L +DPL W
Sbjct: 1746 TQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDW 1795
>CE28250 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2514
Score = 143 bits (360), Expect = 4e-33
Identities = 130/556 (23%), Positives = 232/556 (41%), Gaps = 61/556 (10%)
Query: 2231 INSKLQKEIGTVPSFKFLPWVSQMASKLADSVSPFQDTLQLTLKRMLYKLPYETLYP--- 2287
+N ++Q + + F P + +A + T++ +K+++ ++P++ ++
Sbjct: 1987 MNREIQTALEHIGWRAFYPAYAVLARHIDHQDEEVTRTIKQIMKQLILRMPHQCMWQSAY 2046
Query: 2288 LISMSLQDSESKVIDPVTKSRVEVVNKI---IAALDMYD---------SGRYGSQFTRPV 2335
L+ ++ + K ++ +T EV K + +D YD SG+ S +
Sbjct: 2047 LLRQNIASVKEKYMEVLT----EVKRKAPCYVTLIDQYDYASGVFNTVSGKVESDDCKLS 2102
Query: 2336 QAFCSMSVALACHKIPPKMKFLQLDTLNIGKYWLETLPKVHLPLPTLPVKITCSQDGRRE 2395
+ + K PK + K + V + DG E
Sbjct: 2103 EKVDGLKTMFRDKKYDPKELVMNRRVDCDCKILSGIMVPVRSVIDESVHDTEIRDDGFEE 2162
Query: 2396 G-----RSYISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQV 2450
R I KV + S P I T G R++ K +DDL +D ++
Sbjct: 2163 SCHLPDRYLIHDFSDKVKVLHSNTK-PVIIKLTTKTGRIVRLICK-KDDDLSKDYHFTKM 2220
Query: 2451 FKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISF 2510
+ N +L ++ TR Q ++ TY VIPLG + G+IEF+ S ++ L L ++
Sbjct: 2221 VEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLM---GMTS 2277
Query: 2511 DKARKTMKAAQNH----SVEERVLTFSRITEKIKPQLRRFFFQ-SFVHAHDWYESRNRYT 2565
+ + +K H EER F + K P + +F+ + A W+ SR +
Sbjct: 2278 GEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFA 2337
Query: 2566 KSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRD 2625
KS S++GY+ GLGDRH N+++ TG+ IH+D + F++G+ L PELVPFRLT++
Sbjct: 2338 KSTAVMSVIGYIFGLGDRHTKNLMVHT-TGKCIHVDFDMIFNKGETLGTPELVPFRLTQN 2396
Query: 2626 IVDGFGVAGIEGLFRNNCERVFKVLQD---EKERLLCVLNVLKWDPLYSWKMTPLKKQRL 2682
+++G G ++G FR CE+ +V ++ E E+ + L
Sbjct: 2397 MINGMGEVALDGEFRTVCEQALRVFRENSYEIEKYIADL--------------------- 2435
Query: 2683 QAKFTGDYDEEEISVSDADFS-XXXXXXXXXXXSIRALKGVESKLYGDGLSVEAIVQELL 2741
D+ + + D D S I K S + V + L+
Sbjct: 2436 -PNLVADFPSNKRAPKDFDMSEAKRLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLI 2494
Query: 2742 SSATDKQNLATIYMGW 2757
AT ++ L+ +Y+GW
Sbjct: 2495 ELATSEEKLSEMYLGW 2510
>CE25103 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2531
Score = 143 bits (360), Expect = 4e-33
Identities = 130/556 (23%), Positives = 232/556 (41%), Gaps = 61/556 (10%)
Query: 2231 INSKLQKEIGTVPSFKFLPWVSQMASKLADSVSPFQDTLQLTLKRMLYKLPYETLYP--- 2287
+N ++Q + + F P + +A + T++ +K+++ ++P++ ++
Sbjct: 2004 MNREIQTALEHIGWRAFYPAYAVLARHIDHQDEEVTRTIKQIMKQLILRMPHQCMWQSAY 2063
Query: 2288 LISMSLQDSESKVIDPVTKSRVEVVNKI---IAALDMYD---------SGRYGSQFTRPV 2335
L+ ++ + K ++ +T EV K + +D YD SG+ S +
Sbjct: 2064 LLRQNIASVKEKYMEVLT----EVKRKAPCYVTLIDQYDYASGVFNTVSGKVESDDCKLS 2119
Query: 2336 QAFCSMSVALACHKIPPKMKFLQLDTLNIGKYWLETLPKVHLPLPTLPVKITCSQDGRRE 2395
+ + K PK + K + V + DG E
Sbjct: 2120 EKVDGLKTMFRDKKYDPKELVMNRRVDCDCKILSGIMVPVRSVIDESVHDTEIRDDGFEE 2179
Query: 2396 G-----RSYISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQV 2450
R I KV + S P I T G R++ K +DDL +D ++
Sbjct: 2180 SCHLPDRYLIHDFSDKVKVLHSNTK-PVIIKLTTKTGRIVRLICK-KDDDLSKDYHFTKM 2237
Query: 2451 FKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISF 2510
+ N +L ++ TR Q ++ TY VIPLG + G+IEF+ S ++ L L ++
Sbjct: 2238 VEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIEFMEGVTSFYETLDKLM---GMTS 2294
Query: 2511 DKARKTMKAAQNH----SVEERVLTFSRITEKIKPQLRRFFFQ-SFVHAHDWYESRNRYT 2565
+ + +K H EER F + K P + +F+ + A W+ SR +
Sbjct: 2295 GEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTPVVMGKWFRIQYPEAGQWFASRKLFA 2354
Query: 2566 KSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRD 2625
KS S++GY+ GLGDRH N+++ TG+ IH+D + F++G+ L PELVPFRLT++
Sbjct: 2355 KSTAVMSVIGYIFGLGDRHTKNLMVHT-TGKCIHVDFDMIFNKGETLGTPELVPFRLTQN 2413
Query: 2626 IVDGFGVAGIEGLFRNNCERVFKVLQD---EKERLLCVLNVLKWDPLYSWKMTPLKKQRL 2682
+++G G ++G FR CE+ +V ++ E E+ + L
Sbjct: 2414 MINGMGEVALDGEFRTVCEQALRVFRENSYEIEKYIADL--------------------- 2452
Query: 2683 QAKFTGDYDEEEISVSDADFS-XXXXXXXXXXXSIRALKGVESKLYGDGLSVEAIVQELL 2741
D+ + + D D S I K S + V + L+
Sbjct: 2453 -PNLVADFPSNKRAPKDFDMSEAKRLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLI 2511
Query: 2742 SSATDKQNLATIYMGW 2757
AT ++ L+ +Y+GW
Sbjct: 2512 ELATSEEKLSEMYLGW 2527
>At1g50030 [L] KOG0891 DNA-dependent protein kinase
Length = 2467
Score = 142 bits (357), Expect = 1e-32
Identities = 122/417 (29%), Positives = 199/417 (47%), Gaps = 80/417 (19%)
Query: 2400 ISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILK 2459
ISS ++++ +S P+ T +DG + LLKG ++DLRQD + Q+F VN +L+
Sbjct: 2067 ISSFSRQLVVITSK-QRPRKLTIHGNDGEDYAFLLKG-HEDLRQDERVMQLFGLVNTLLE 2124
Query: 2460 ANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTMKA 2519
++ T +++LS++ Y VIPL P +GLI +V N +LH ++ ARK +
Sbjct: 2125 NSRKTAEKDLSIQRYSVIPLSPNSGLIGWVPNCDTLHHLIREHR--------DARKIILN 2176
Query: 2520 AQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLG 2579
+N + +L+F+ + + P + + + F +A + E + S VGY+LG
Sbjct: 2177 QEN----KHMLSFAPDYDNL-PLIAKV--EVFEYALENTEGNDL--------SRVGYILG 2221
Query: 2580 LGDRHLNNILIDIKTGEPIHIDLGVAFDQG-KLLPIPELVPFRLTRDIVDGFGVAGIEGL 2638
LGDRH +N+++ +G+ +HID G F+ PE VPFRLTR +V V+GIEG
Sbjct: 2222 LGDRHPSNLMLHRYSGKILHIDFGDCFEASMNREKFPEKVPFRLTRMLVKAMEVSGIEGN 2281
Query: 2639 FRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKM------------------------ 2674
FR+ CE V +VL+ K+ ++ ++ DPL +W++
Sbjct: 2282 FRSTCENVMQVLRTNKDSVMAMMEAFVHDPLINWRLFNFNEVPQLALLGNNNPNAPADVE 2341
Query: 2675 ------------------TPLKKQRLQA-KFTGDYDE---EEISVSDADFSXXXXXXXXX 2712
+ +K+ LQA GD +E E V A S
Sbjct: 2342 PDEEDEDPADIDLPQPQRSTREKEILQAVNMLGDANEVLNERAVVVMARMSHKLTGRDFS 2401
Query: 2713 XXSIRA--------LKGVESKLYGDGLSVEAIVQELLSSATDKQNLATIYMGWSPFY 2761
+I + L G +S GLSV+ VQ+L++ AT +NL Y+G+ P +
Sbjct: 2402 SSAIPSNPIADHNNLLGGDSHEVEHGLSVKVQVQKLINQATSHENLCQNYVGYVPLH 2458
>CE27869 [L] KOG0891 DNA-dependent protein kinase
Length = 2327
Score = 137 bits (345), Expect = 2e-31
Identities = 90/291 (30%), Positives = 139/291 (46%), Gaps = 36/291 (12%)
Query: 2417 PKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSV---RT 2473
PK F SDG + L KG +DL D + Q + N +L+ K +Q+++
Sbjct: 1772 PKKLGFVGSDGKQVAFLFKG-REDLHLDERVMQFLRLCNVMLQPGKGKHRQSVAAYQAHH 1830
Query: 2474 YEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTMK--------------- 2518
Y VIPLGPR+GLI++V + + I ++ +K +
Sbjct: 1831 YAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKALKQATKKNGETVPEIERPSNMYHNM 1890
Query: 2519 ---AAQNHSVEERVLT-------------FSRITEKIKPQL-RRFFFQSFVHAHDWYESR 2561
A +H ++ + + F +T K L R + A W+
Sbjct: 1891 IRLAFADHKIDSSITSDRSKWPAEILEEVFESLTAKTPTDLISRELWMRANDATTWWSVT 1950
Query: 2562 NRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFR 2621
RY++S+ S+VG +LGLGDRHL+N+L+D+K G +HID + FD+GK L IPE VPFR
Sbjct: 1951 KRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVVHIDYNICFDKGKNLRIPETVPFR 2010
Query: 2622 LTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSW 2672
LTR++ G + + G FR +C V L+ + L +L+ +DPL W
Sbjct: 2011 LTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQVLTMLLDAFVFDPLVDW 2061
>Hs13654237 [L] KOG0891 DNA-dependent protein kinase
Length = 4128
Score = 126 bits (316), Expect = 6e-28
Identities = 112/411 (27%), Positives = 179/411 (43%), Gaps = 52/411 (12%)
Query: 2400 ISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILK 2459
I+ D +V + +S L PK D H L+KG +DLRQD +EQ+F+ +N IL
Sbjct: 3719 IAGFDERVTVMAS-LRRPKRIIIRGHDEREHPFLVKGG-EDLRQDQRVEQLFQVMNGILA 3776
Query: 2460 ANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDE----ISFDKARK 2515
+ ++ L +RTY V+P+ R GLIE++ N+++L D+LLN +E +S +A
Sbjct: 3777 QDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPP 3836
Query: 2516 ------TMKAAQNHSV------------EERVLTFSRITEKIKPQ-LRRFFFQSFVHAHD 2556
K + H V E V +F + K+ L+R F +
Sbjct: 3837 CEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEA 3896
Query: 2557 WYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQG-KLLPIP 2615
+ R+ + S I ++LG+GDRHLNN ++ ++TG I ID G AF + LP+P
Sbjct: 3897 FLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVP 3956
Query: 2616 ELVPFRLTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWK-- 2673
EL+PFRLTR ++ GL + + + + L ++V +P + WK
Sbjct: 3957 ELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNF 4016
Query: 2674 -MTPLKK-----QRLQAKFTGDYDEEEISVSDADFSXXXXXXXXXXXSI----------- 2716
LKK Q + Y ++I + + +
Sbjct: 4017 EQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRD 4076
Query: 2717 -----RALK--GVESKLYGDGLSVEAIVQELLSSATDKQNLATIYMGWSPF 2760
R K + ++ GLS E V+ L+ ATD L + GW P+
Sbjct: 4077 YVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPW 4127
>7290761 [L] KOG0891 DNA-dependent protein kinase
Length = 2162
Score = 110 bits (274), Expect = 4e-23
Identities = 77/269 (28%), Positives = 131/269 (48%), Gaps = 34/269 (12%)
Query: 2399 YISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKIL 2458
YI S++ V + + PK F S+G R+ L KG D + IM+ F ++ +
Sbjct: 1893 YIESVESSVCVLPTKTK-PKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQ--FLSISNAI 1949
Query: 2459 KANKTTRKQNLSVRT--YEVIPLGPRAGLIEFVANSMSLHDI------------------ 2498
A ++ N R Y VIPLGP++GLI +V + +
Sbjct: 1950 MACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAGNAGAG 2009
Query: 2499 -LLNLHCNDEISFDKARKTMKAAQNHSVEER-----VLTFSRITEKIKPQ-----LRRFF 2547
+ N+ F + A N V + + ++ +++ + L R
Sbjct: 2010 AVANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLAREL 2069
Query: 2548 FQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFD 2607
+ +A +W +S R+ + + S++GY++GLGDRHL+N+LI++ +G+ +HID V F+
Sbjct: 2070 WCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFE 2129
Query: 2608 QGKLLPIPELVPFRLTRDIVDGFGVAGIE 2636
+G+ L IPE VPFRLT+++V G+ GIE
Sbjct: 2130 KGRTLRIPEKVPFRLTQNLVQAMGITGIE 2158
>Hs18589256 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 887
Score = 75.5 bits (184), Expect = 1e-12
Identities = 76/305 (24%), Positives = 132/305 (42%), Gaps = 61/305 (20%)
Query: 2400 ISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILK 2459
I I P+ +P F DG ++ V+ K DDLRQD ++ Q+ ++K+L
Sbjct: 601 IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFK-HGDDLRQDQLILQIISLMDKLL- 658
Query: 2460 ANKTTRKQNLSVRT--YEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTM 2517
RK+NL ++ Y+V+ + G ++F+ S+ + ++L T
Sbjct: 659 -----RKENLDLKLTPYKVLATSTKHGFMQFI-QSVPVAEVL---------------DTE 697
Query: 2518 KAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDW-----YESRNRYTKSVVTSS 2572
+ QN FF+ + + + E + Y KS
Sbjct: 698 GSIQN------------------------FFRKYAPSENGPNGISAEVMDTYVKSCAGYC 733
Query: 2573 IVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGFGV 2632
++ Y+LG+GDRHL+N+L+ KTG+ HID G + P P P +L +++V+G G
Sbjct: 734 VITYILGVGDRHLDNLLL-TKTGKLFHIDFGYILGRD---PKPLPPPMKLNKEMVEGMGG 789
Query: 2633 AGIEGL--FRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKK-QRLQAKFTGD 2689
E FR C F L+ +L + +++ + + P K +++Q KF D
Sbjct: 790 TQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLD 849
Query: 2690 YDEEE 2694
+EE
Sbjct: 850 LSDEE 854
>Hs4505801 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 887
Score = 74.7 bits (182), Expect = 2e-12
Identities = 75/305 (24%), Positives = 132/305 (42%), Gaps = 61/305 (20%)
Query: 2400 ISSIDPKVLISSSGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQVFKQVNKILK 2459
I I P+ +P F DG ++ V+ K DDLRQD ++ Q+ ++K+L
Sbjct: 601 IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFK-HGDDLRQDQLILQIISLMDKLL- 658
Query: 2460 ANKTTRKQNLSVRT--YEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISFDKARKTM 2517
RK+NL ++ Y+V+ + G ++F+ S+ + ++L T
Sbjct: 659 -----RKENLDLKLTPYKVLATSTKHGFMQFI-QSVPVAEVL---------------DTE 697
Query: 2518 KAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDW-----YESRNRYTKSVVTSS 2572
+ QN FF+ + + + E + Y KS
Sbjct: 698 GSIQN------------------------FFRKYAPSENGPNGISAEVMDTYVKSCAGYC 733
Query: 2573 IVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGFGV 2632
++ Y+LG+GDRHL+N+++ KTG+ HID G + P P P +L +++V+G G
Sbjct: 734 VITYILGVGDRHLDNLVL-TKTGKLFHIDFGYILGRD---PKPLPPPMKLNKEMVEGMGG 789
Query: 2633 AGIEGL--FRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKK-QRLQAKFTGD 2689
E FR C F L+ +L + +++ + + P K +++Q KF D
Sbjct: 790 TQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDPNIPDIALEPDKTVKKVQDKFRLD 849
Query: 2690 YDEEE 2694
+EE
Sbjct: 850 LSDEE 854
>At2g17930 [TBLD] KOG0889 Histone acetyltransferase SAGA TRRAP/TRA1 component
PI-3 kinase superfamily
Length = 3795
Score = 72.8 bits (177), Expect = 7e-12
Identities = 62/268 (23%), Positives = 123/268 (45%), Gaps = 17/268 (6%)
Query: 2421 TFTVSDGT-RHRVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPL 2479
T SDG+ +H ++ + R D + Q+F+ +N++ +K +R++++ + T +IP+
Sbjct: 3440 TLIGSDGSQKHFIVQTSLTPNARSDERILQLFRVMNQMFDKHKESRRRHIGIHTPIIIPV 3499
Query: 2480 GPRAGLIEFVANSMSLHDILLNLHC--NDE-----ISFDKARKTMKAAQNHSVEE----R 2528
+ ++E + ++ N HC ND I+ K + + S E R
Sbjct: 3500 WSQVRMVEDDLMYNTFLEVYEN-HCARNDREADLPITHFKEQLNQAISGQISAEAIGDLR 3558
Query: 2529 VLTFSRITEKIKPQ--LRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLN 2586
+ + IT+ + ++ +++ + + + ++ + SS + ++L +G R N
Sbjct: 3559 LQAYIDITKTLVNDSIFSQYMYKTLMSGSHMWAFKKQFAVQLAVSSFMSFMLQIGGRSPN 3618
Query: 2587 NILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGFGVAGIEGLFRNN-CER 2645
+L TG+ D A+D ++ E VPFRLTR++ F G+EGL ++ C
Sbjct: 3619 KVLFAKNTGKMFQTDFHPAYDANGMIEFNEPVPFRLTRNMQAFFSQFGVEGLLMSSMCSA 3678
Query: 2646 VFKVLQD-EKERLLCVLNVLKWDPLYSW 2672
V+ + E L L + D L SW
Sbjct: 3679 AQAVISSKQNEHLRYQLAMFFRDELLSW 3706
>CE04513 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 604
Score = 70.1 bits (170), Expect = 5e-11
Identities = 68/256 (26%), Positives = 108/256 (41%), Gaps = 40/256 (15%)
Query: 2384 VKITCSQDGRREGRSYISSIDPKVLISSSGLSLPKIATFTVSDGTRHR------VLLKGS 2437
+K + S+ + +SY S DP + + + + K S H+ V++K +
Sbjct: 283 IKKSQSESVLLKNKSYHDSTDPSIAVFAESWAEKKARIRGSSRYENHQKWDLIPVIVK-T 341
Query: 2438 NDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHD 2497
DDL Q+A +Q+ + L +R Y+++ +G AGLIE V +++SLH
Sbjct: 342 GDDLSQEAFAQQLLFTFKDLWHEEGVP----LYLRPYKIVCIGSDAGLIEPVLDTLSLHQ 397
Query: 2498 ILLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSF--VHAH 2555
I K T N +V P L+ F F V++
Sbjct: 398 I-------------KRHLTNVFRMNGNVTT-------------PSLKHHFENVFGPVNSE 431
Query: 2556 DWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIP 2615
+ ++ + +S S+V Y L L DRH NIL+D+ G IHID G
Sbjct: 432 TYVNAQKNFIQSTAAYSLVSYYLQLKDRHNGNILLDM-DGHLIHIDYGFLLSSSPRNLGF 490
Query: 2616 ELVPFRLTRDIVDGFG 2631
E PF+LT +I+D G
Sbjct: 491 ETAPFKLTTEIIDVMG 506
>SPAC22E12.16c [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 851
Score = 68.9 bits (167), Expect = 1e-10
Identities = 59/228 (25%), Positives = 107/228 (46%), Gaps = 28/228 (12%)
Query: 2440 DLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDIL 2499
DLRQ+ Q+ ++ K+ + VR +++ G +GLIE + N++S+H I
Sbjct: 588 DLRQETFACQLIYAFQRVW----LECKEKVWVRRMKILVTGDNSGLIETITNAISVHSIK 643
Query: 2500 LNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSF--VHAHDW 2557
NL K + + AQ + V+T L+ +F + F ++ +
Sbjct: 644 KNL--------TKQLREAELAQGKIAGKNVVT-----------LKDYFIKQFGDPNSSRY 684
Query: 2558 YESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPEL 2617
+++ + +S+V SI+ YLL L DRH N+LID G IHID G E
Sbjct: 685 RQAQTNFLQSLVAYSIISYLLQLKDRHNGNVLID-SEGHIIHIDFGFLLTNTPGNVGFES 743
Query: 2618 VPFRLTRDIVDGFGVAGIEGLFRNNCERVFKVLQDEKERLLCVLNVLK 2665
PF+LT D ++ E +R+ + FK ++ ++++ ++ V++
Sbjct: 744 APFKLTADYLEILDDRFDE--YRSLMKAAFKSVRKNADQIILLVEVMQ 789
>YNL267w [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1066
Score = 63.2 bits (152), Expect = 6e-09
Identities = 61/266 (22%), Positives = 118/266 (43%), Gaps = 36/266 (13%)
Query: 2437 SNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLH 2496
+ DDLRQ+A Q+ + + I K ++ V+ +++ GL+E + N+MS+H
Sbjct: 797 TGDDLRQEAFAYQMIQAMANIWVKEKV----DVWVKRMKILITSANTGLVETITNAMSVH 852
Query: 2497 DILLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHD 2556
I K T K ++ ++++ S L F ++F + +
Sbjct: 853 SI-------------KKALTKKMIEDAELDDKGGIAS---------LNDHFLRAFGNPNG 890
Query: 2557 --WYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPI 2614
+ +++ + S+ S++ YLL + DRH NI+ID G HID G
Sbjct: 891 FKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMID-NEGHVSHIDFGFMLSNSPGSVG 949
Query: 2615 PELVPFRLTRDIVDGFGVAGIEG----LFRNNCERVFKVLQDEKERLLCVLNVLKWDPLY 2670
E PF+LT + ++ G G+EG F + FK L+ ++++ + +++ D +
Sbjct: 950 FEAAPFKLTYEYIELLG--GVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQ 1007
Query: 2671 -SWKMTPLKKQRLQAKFTGDYDEEEI 2695
+ +L+ +F D E+E+
Sbjct: 1008 PCFDAGEQTSVQLRQRFQLDLSEKEV 1033
>At1g60490 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 814
Score = 62.4 bits (150), Expect = 1e-08
Identities = 75/306 (24%), Positives = 129/306 (41%), Gaps = 57/306 (18%)
Query: 2401 SSIDPKVLISS----------SGLSLPKIATFTVSDGTRHRVLLKGSNDDLRQDAIMEQV 2450
S + P VLI S L ++ T +G +++ K DDLRQD ++ Q+
Sbjct: 520 SPLTPNVLIKGIVAGESSLFKSALHPLRLTFRTPEEGGSCKLIFK-KGDDLRQDQLVVQM 578
Query: 2451 FKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLNLHCNDEISF 2510
++++LK +L + Y+V+ G G++EF+ S SL IL
Sbjct: 579 VWLMDRLLKLENL----DLCLTPYKVLATGHDEGMLEFIP-SRSLAQILS---------- 623
Query: 2511 DKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVT 2570
E R +T L++F + + KS
Sbjct: 624 ---------------EHRSIT---------SYLQKFHPDEHAPFGITATCLDTFIKSCAG 659
Query: 2571 SSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGKLLPIPELVPFRLTRDIVDGF 2630
S++ Y+LG+GDRHL+N+L+ G H+D AF G+ P P P +L +++V+
Sbjct: 660 YSVITYILGIGDRHLDNLLL-TDDGRLFHVDF--AFILGR-DPKPFPPPMKLCKEMVEAM 715
Query: 2631 GVAGIE--GLFRNNCERVFKVLQDEKERLLCVLNVLKWDPLYSWKMTPLKK-QRLQAKFT 2687
G A + F++ C + +L+ +L + +++ + P K +LQ KF
Sbjct: 716 GGAESQYYTRFKSYCCEAYNILRKSSNLILNLFHLMAGSTIPDIASDPEKGILKLQEKFR 775
Query: 2688 GDYDEE 2693
D D+E
Sbjct: 776 LDMDDE 781
>CE23506 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1146
Score = 58.9 bits (141), Expect = 1e-07
Identities = 48/195 (24%), Positives = 88/195 (44%), Gaps = 48/195 (24%)
Query: 2437 SNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLH 2496
+ DDLRQD ++ QV + ++ I KA + + Y V+P+G G+IE V N ++
Sbjct: 855 NGDDLRQDMLVLQVLEVMDNIWKAANI----DCCLNPYAVLPMGEMIGIIEVVPNCKTIF 910
Query: 2497 DI---------------------LLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRI 2535
+I + C E D+ +K+ K + + +E+++
Sbjct: 911 EIQVGTGFMNTAVRSIDPSFMNKWIRKQCGIE---DEKKKSKKDSTKNPIEKKIDN---- 963
Query: 2536 TEKIKPQLRRFFFQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTG 2595
T+ +K ++ES +R+ S V S+ Y++G+ DRH +N+++ + G
Sbjct: 964 TQAMK---------------KYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLML-TEDG 1007
Query: 2596 EPIHIDLGVAFDQGK 2610
+ HID G GK
Sbjct: 1008 KYFHIDFGHILGHGK 1022
>At5g09350 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1116
Score = 58.9 bits (141), Expect = 1e-07
Identities = 69/272 (25%), Positives = 112/272 (40%), Gaps = 49/272 (18%)
Query: 2431 RVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVA 2490
R ++ S DD RQ+ + Q+ I + L +R YEV+ LIE +
Sbjct: 854 RSIIVKSGDDCRQEHLAVQLISHFFDIFQEAGLP----LWLRPYEVLVTSSYTALIETIP 909
Query: 2491 NSMSLHDILLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQS 2550
++ S+H I K+R + IT LR FF
Sbjct: 910 DTASIHSI-------------KSR-----------------YPNITS-----LRDFFDAK 934
Query: 2551 FVHAHDWYESRNR-YTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQG 2609
F ++ R + +S+ S+V YLL + DRH N+L+D + G IHID G
Sbjct: 935 FKENSPSFKLAQRNFVESMAGYSLVCYLLQIKDRHNGNLLMD-EEGHIIHIDFGFMLSNS 993
Query: 2610 KLLPIPELVPFRLTRDIVDGFGVAGIEGL-------FRNNCERVFKVLQDEKERLLCVLN 2662
E PF+LTR++++ + EGL F+ C + F + ER++ ++
Sbjct: 994 PGGVNFESAPFKLTRELLEVMD-SDAEGLPSEFFDYFKVLCIQGFLTCRKHAERIILLVE 1052
Query: 2663 VLKWDPLYSWKMTPLKKQRLQAKFTGDYDEEE 2694
+L+ +K P Q L+ +F EE+
Sbjct: 1053 MLQDSGFPCFKGGPRTIQNLRKRFHLSLTEEQ 1084
>At5g64070 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1121
Score = 57.8 bits (138), Expect = 2e-07
Identities = 68/271 (25%), Positives = 111/271 (40%), Gaps = 47/271 (17%)
Query: 2431 RVLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVA 2490
R ++ S DD RQ+ + Q+ I + L +R YEV+ LIE +
Sbjct: 859 RSIIVKSGDDCRQEHLAVQLISHFYDIFQEAGLP----LWLRPYEVLVTSSYTALIETIP 914
Query: 2491 NSMSLHDILLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQS 2550
++ S+H I K+R + IT LR FF
Sbjct: 915 DTASIHSI-------------KSR-----------------YPNITS-----LRDFFVAK 939
Query: 2551 FVHAHDWYESRNR-YTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQG 2609
+ ++ R + +S+ S+V YLL + DRH N+L+D + G IHID G
Sbjct: 940 YKENSPSFKLAQRNFVESMAGYSLVCYLLQVKDRHNGNLLLD-EEGHIIHIDFGFMLSNS 998
Query: 2610 KLLPIPELVPFRLTRDIV-----DGFGV-AGIEGLFRNNCERVFKVLQDEKERLLCVLNV 2663
E PF+LTR+++ D GV + F+ C + F + ER++ ++ +
Sbjct: 999 PGGVNFESAPFKLTRELLEVMDSDADGVPSEFFDYFKVLCIQGFLTCRKHAERIILLVEM 1058
Query: 2664 LKWDPLYSWKMTPLKKQRLQAKFTGDYDEEE 2694
L+ +K P Q L+ +F EE+
Sbjct: 1059 LQDSGFPCFKGGPRTIQNLRKRFHLSLTEEQ 1089
>HsM4505803 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1101
Score = 57.0 bits (136), Expect = 4e-07
Identities = 59/233 (25%), Positives = 103/233 (43%), Gaps = 41/233 (17%)
Query: 2439 DDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDI 2498
DDLRQD ++ Q+ + + I + T +L + Y I G + G+IE V ++ ++ I
Sbjct: 835 DDLRQDMLILQILRIMESIWE----TESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKI 890
Query: 2499 LLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDWY 2558
+ N D+ NH ++E+ S EK + + RF +
Sbjct: 891 QQSTVGNTGAFKDEVL-------NHWLKEK----SPTEEKFQAAVERFVY---------- 929
Query: 2559 ESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLG-VAFDQGKLLPI-PE 2616
S + ++LG+GDRH +NI+I +TG HID G + + L I E
Sbjct: 930 --------SCAGYCVATFVLGIGDRHNDNIMI-TETGNLFHIDFGHILGNYKSFLGINKE 980
Query: 2617 LVPFRLTRDIVDGFGVAGIE-----GLFRNNCERVFKVLQDEKERLLCVLNVL 2664
VPF LT D + G +G + F++ C + + L+ L+ + +++
Sbjct: 981 RVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMM 1033
>Hs21237725 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1102
Score = 57.0 bits (136), Expect = 4e-07
Identities = 59/233 (25%), Positives = 103/233 (43%), Gaps = 41/233 (17%)
Query: 2439 DDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDI 2498
DDLRQD ++ Q+ + + I + T +L + Y I G + G+IE V ++ ++ I
Sbjct: 836 DDLRQDMLILQILRIMESIWE----TESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKI 891
Query: 2499 LLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSFVHAHDWY 2558
+ N D+ NH ++E+ S EK + + RF +
Sbjct: 892 QQSTVGNTGAFKDEVL-------NHWLKEK----SPTEEKFQAAVERFVY---------- 930
Query: 2559 ESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLG-VAFDQGKLLPI-PE 2616
S + ++LG+GDRH +NI+I +TG HID G + + L I E
Sbjct: 931 --------SCAGYCVATFVLGIGDRHNDNIMI-TETGNLFHIDFGHILGNYKSFLGINKE 981
Query: 2617 LVPFRLTRDIVDGFGVAGIE-----GLFRNNCERVFKVLQDEKERLLCVLNVL 2664
VPF LT D + G +G + F++ C + + L+ L+ + +++
Sbjct: 982 RVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMM 1034
>ECU03g1100 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 711
Score = 56.6 bits (135), Expect = 5e-07
Identities = 56/230 (24%), Positives = 100/230 (43%), Gaps = 48/230 (20%)
Query: 2432 VLLKGSNDDLRQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVAN 2491
V++K N L Q+ + QV ++ +I + + + +R Y++ + +G++E V +
Sbjct: 457 VIVKTGNS-LMQELMAYQVLCEMKRIWREEGSP----IWIRAYQIYLISDTSGIVETVVD 511
Query: 2492 SMSLHDILLNLHCNDEISFDKARKTMKAAQNHSVEERVLTFSRITEKIKPQLRRFFFQSF 2551
+MS+H I +K M +N+S LR +F SF
Sbjct: 512 AMSIHKI--------------KKKMMSENKNYS------------------LRNYFADSF 539
Query: 2552 VHAHDWYESRNR-YTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHIDLGVAFDQGK 2610
Y+S R + S+V S+ Y+L + DRH NI+ID G +H+D G
Sbjct: 540 ELNSAKYKSCLRNFLYSLVGYSLATYILQVKDRHNGNIMID-GQGHIVHVDFGFVMGGHP 598
Query: 2611 LLPIPELVPFRLTR-------DIVDGFGVAGIEGL--FRNNCERVFKVLQ 2651
E PF+ ++ D+VD F + G R + R+F++++
Sbjct: 599 GFYCVEAAPFKFSKEYLELLGDLVDEFKDLFLRGYMELRKHSSRLFRIIE 648
>YHR099w [TBLD] KOG0889 Histone acetyltransferase SAGA TRRAP/TRA1 component
PI-3 kinase superfamily
Length = 3744
Score = 54.7 bits (130), Expect = 2e-06
Identities = 60/263 (22%), Positives = 110/263 (41%), Gaps = 34/263 (12%)
Query: 2442 RQDAIMEQVFKQVNKILKANKTTRKQNLSVRTYEVIPLGPRAGLIEFVANSMSLHDILLN 2501
R++ M Q+++ NK L N TR++++ IPL P+ ++ + +LH+I N
Sbjct: 3414 RREERMFQLYRLFNKSLSKNVETRRRSIQFNLPIAIPLSPQVRIMNDSVSFTTLHEIH-N 3472
Query: 2502 LHCN------DEISFDKARKTMKAAQNHSVEERVLT------FSRITEKIKPQ--LRRFF 2547
C D+I A K + AA + ++ +T F+ I P L+ F
Sbjct: 3473 EFCKKKGFDPDDIQDFMADK-LNAAHDDALPAPDMTILKVEIFNSIQTMFVPSNVLKDHF 3531
Query: 2548 FQSFVHAHDWYESRNRYTKSVVTSSIVGYLLGLGDRHLNNILIDIKTGEPIHID-LGVAF 2606
F D++ R ++ + + Y++ + +R + I +D +G ++ L F
Sbjct: 3532 TSLFTQFEDFWLFRKQFASQYSSFVFMSYMMMINNRTPHKIHVDKTSGNVFTLEMLPSRF 3591
Query: 2607 DQGKLLPI-----------------PELVPFRLTRDIVDGFGVAGIEGLFRNNCERVFKV 2649
++ P+ E VPFRLT +I G + +EG+F N + +
Sbjct: 3592 PYERVKPLLKNHDLSLPPDSPIFHNNEPVPFRLTPNIQSLIGDSALEGIFAVNLFTISRA 3651
Query: 2650 LQDEKERLLCVLNVLKWDPLYSW 2672
L + L L + D + SW
Sbjct: 3652 LIEPDNELNTYLALFIRDEIISW 3674
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.323 0.137 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 154,375,156
Number of Sequences: 60738
Number of extensions: 6568109
Number of successful extensions: 16572
Number of sequences better than 1.0e-05: 44
Number of HSP's better than 0.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 16301
Number of HSP's gapped (non-prelim): 172
length of query: 2761
length of database: 30,389,216
effective HSP length: 124
effective length of query: 2637
effective length of database: 22,857,704
effective search space: 60275765448
effective search space used: 60275765448
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)