ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV1920 good C KOG1494 Energy production and conversion NAD-dependent malate dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV1920 680096 678885 -404
(404 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOL126c [C] KOG1494 NAD-dependent malate dehydrogenase 361 e-100
YKL085w [C] KOG1494 NAD-dependent malate dehydrogenase 209 8e-54
YDL078c [C] KOG1494 NAD-dependent malate dehydrogenase 204 1e-52
7300357 [C] KOG1494 NAD-dependent malate dehydrogenase 196 4e-50
SPCC306.08c [C] KOG1494 NAD-dependent malate dehydrogenase 195 1e-49
At3g15020 [C] KOG1494 NAD-dependent malate dehydrogenase 189 6e-48
At3g47520 [C] KOG1494 NAD-dependent malate dehydrogenase 187 2e-47
CE09512 [C] KOG1494 NAD-dependent malate dehydrogenase 185 9e-47
HsM5174541 [C] KOG1494 NAD-dependent malate dehydrogenase 182 1e-45
Hs21735621 [C] KOG1494 NAD-dependent malate dehydrogenase 182 1e-45
At1g53240 [C] KOG1494 NAD-dependent malate dehydrogenase 181 1e-45
7294520 [C] KOG1494 NAD-dependent malate dehydrogenase 171 1e-42
At5g09660 [C] KOG1494 NAD-dependent malate dehydrogenase 171 2e-42
At2g22780 [C] KOG1494 NAD-dependent malate dehydrogenase 168 2e-41
7294521 [C] KOG1494 NAD-dependent malate dehydrogenase 155 1e-37
At5g58330 [C] KOG1496 Malate dehydrogenase 58 3e-08
Hs5031857 [C] KOG1495 Lactate dehydrogenase 57 5e-08
Hs4504973 [C] KOG1495 Lactate dehydrogenase 55 1e-07
Hs5174539 [C] KOG1496 Malate dehydrogenase 54 4e-07
Hs21450657 [C] KOG1495 Lactate dehydrogenase 54 4e-07
CE20820 [C] KOG1496 Malate dehydrogenase 53 7e-07
At5g43330 [C] KOG1496 Malate dehydrogenase 53 7e-07
At5g56720 [C] KOG1496 Malate dehydrogenase 52 1e-06
7297683 [C] KOG1496 Malate dehydrogenase 52 1e-06
At1g04410 [C] KOG1496 Malate dehydrogenase 52 2e-06
SPAC186.08c [C] KOG1495 Lactate dehydrogenase 50 5e-06
>YOL126c [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 423
Score = 361 bits (927), Expect = e-100
Identities = 194/383 (50%), Positives = 271/383 (70%), Gaps = 20/383 (5%)
Query: 30 NFFHKEMPAVNAQEKEILKISVLGAAGGIGQSLSLLLKSNAGFLLP--HETSTHIRLSLY 87
N H P++ E++ LKI++LGAAGGIGQSLSLLLK+ + L + + THI L+LY
Sbjct: 46 NMPHSVTPSI---EQDSLKIAILGAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALY 102
Query: 88 DVNKDAIVGTAADLSHIDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRD 147
DVN++AI G ADLSHIDTPI+ ++H P GGI CL NAS+V+IPAGVPRKPGM+RD
Sbjct: 103 DVNQEAINGVTADLSHIDTPISVSSHSPA---GGIENCLHNASIVVIPAGVPRKPGMTRD 159
Query: 148 DLIGVNAKIIKSLGEDIAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANG-NSNIES 206
DL VNA II LG+ IA+ CDL+KV VLVISNP+NSLVP++ + ++++ NS IE
Sbjct: 160 DLFNVNAGIISQLGDSIAECCDLSKVFVLVISNPVNSLVPVMVSNILKNHPQSRNSGIER 219
Query: 207 RVYGITQLDLVRSSTFVQQLN---GF--KSNTSPVIPVIGGHSGDTIIPVFSTLERDPEY 261
R+ G+T+LD+VR+STF++++N G + N+ P +PVIGGHSG+TIIP+FS +
Sbjct: 220 RIMGVTKLDIVRASTFLREINIESGLTPRVNSMPDVPVIGGHSGETIIPLFS----QSNF 275
Query: 262 ANLLDNGMRLKMVHRVQYGGDEIVKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTID 321
+ L+ ++HRVQYGGDE+VKAKNG GSATLSMA+AG+K +F+ LL+GN + I
Sbjct: 276 LSRLNEDQLKYLIHRVQYGGDEVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQIH 335
Query: 322 DIVMYVPLTNRNHQEIAPGSNELRSRYINDLLYFSIPLSINRNGIKKIHYEILENLDSYE 381
YVPL + N+ IAPG+++L ++ YF+IPL+I G+ + Y+I+ ++ E
Sbjct: 336 G-TYYVPLKDANNFPIAPGADQLLP-LVDGADYFAIPLTITTKGVSYVDYDIVNRMNDME 393
Query: 382 RDTLLPICLKTLEGNIETGLKLV 404
R+ +LPIC+ L+ NI+ GL+ V
Sbjct: 394 RNQMLPICVSQLKKNIDKGLEFV 416
>YKL085w [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 334
Score = 209 bits (531), Expect = 8e-54
Identities = 139/360 (38%), Positives = 197/360 (54%), Gaps = 50/360 (13%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K++VLGA GGIGQ LSLLLK N H+ + L LYD+ G A DLSHI T
Sbjct: 19 KVTVLGAGGGIGQPLSLLLKLN------HKVTD---LRLYDLK--GAKGVATDLSHIPTN 67
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
P++ +G + L + +V+IPAGVPRKPGM+RDDL +NA I++ L A+
Sbjct: 68 SVVKGFTPEEPDG-LNNALKDTDMVLIPAGVPRKPGMTRDDLFAINASIVRDLAAATAES 126
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
+LVISNP+NS VP++ L N +++G+T LD +R++ F+ ++
Sbjct: 127 AP--NAAILVISNPVNSTVPIVAQVL----KNKGVYNPKKLFGVTTLDSIRAARFISEVE 180
Query: 228 GFKSNTSPV---IPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDEI 284
NT P + VIGGHSG TIIP+ S L+ + R +++HR+Q+GGDE+
Sbjct: 181 ----NTDPTQERVNVIGGHSGITIIPLISQTNH-----KLMSDDKRHELIHRIQFGGDEV 231
Query: 285 VKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNEL 344
VKAKNG GSATLSMA+AG K A + G D I+ + PL E
Sbjct: 232 VKAKNGAGSATLSMAHAGAKFANAVLSGFKGERDVIEPSFVDSPLFKSEGIE-------- 283
Query: 345 RSRYINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPICLKTLEGNIETGLKLV 404
+F+ P+++ +GI+KIH + L S E + +L C +TL+ NIE G+ V
Sbjct: 284 ---------FFASPVTLGPDGIEKIH--PIGELSS-EEEEMLQKCKETLKKNIEKGVNFV 331
>YDL078c [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 343
Score = 204 bits (520), Expect = 1e-52
Identities = 145/376 (38%), Positives = 200/376 (52%), Gaps = 56/376 (14%)
Query: 46 ILKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHID 105
++K+++LGA+GG+GQ LSLLLK L P+ + L+LYD+ A G DLSHI+
Sbjct: 1 MVKVAILGASGGVGQPLSLLLK-----LSPYVSE----LALYDIR--AAEGIGKDLSHIN 49
Query: 106 TPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIA 165
T ++ Y DS I LSNA VV+IPAGVPRKPG++RDDL +NA I+KSL +
Sbjct: 50 TN-SSCVGYDKDS---IENTLSNAQVVLIPAGVPRKPGLTRDDLFKMNAGIVKSLVTAVG 105
Query: 166 KYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQ 225
K+ +LVISNP+NSLVP+ TL + N V G+T LDLVR+ TF+
Sbjct: 106 KFAP--NARILVISNPVNSLVPIAVETLKKMGKFKPGN----VMGVTNLDLVRAETFLVD 159
Query: 226 L----------NGFKSNTSPVIPVIGGHSGDTIIPVFS----TLERDPEYANLLDNGMRL 271
K+ + VIGGHSG+TIIP+ + + D +Y +
Sbjct: 160 YLMLKNPKIGQEQDKTTMHRKVTVIGGHSGETIIPIITDKSLVFQLDKQYEH-------- 211
Query: 272 KMVHRVQYGGDEIVKAKNGNGSATLSMAYAGFKIAAKFIDLLVG---NTDTIDDIVMYVP 328
+HRVQ+GGDEIVKAK G GSATLSMA+AG K A + + T+++ V
Sbjct: 212 -FIHRVQFGGDEIVKAKQGAGSATLSMAFAGAKFAEEVLRSFHNEKPETESLSAFVYLPG 270
Query: 329 LTNRNHQEIAPGSNELRSRYINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPI 388
L N + G N + YFS+P+ + + I +LE L E + L+
Sbjct: 271 LKNGKKAQQLVGDNSIE--------YFSLPIVLRNGSVVSIDTSVLEKLSPRE-EQLVNT 321
Query: 389 CLKTLEGNIETGLKLV 404
+K L NIE G +
Sbjct: 322 AVKELRKNIEKGKSFI 337
>7300357 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 336
Score = 196 bits (499), Expect = 4e-50
Identities = 142/354 (40%), Positives = 190/354 (53%), Gaps = 48/354 (13%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K++V GAAGGIGQ LSLLLK N P T L+LYD+ G AADLSHIDT
Sbjct: 26 KVTVCGAAGGIGQPLSLLLKQN-----PLVTD----LALYDIVHTP--GVAADLSHIDTK 74
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
T D +G L + VV+IPAGVPRKPGM+RDDL VNA IIK + IAK
Sbjct: 75 SKTAGFIGADQ---LGDSLKGSDVVVIPAGVPRKPGMTRDDLFNVNAGIIKDISNSIAKN 131
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
C K V +I+NP+N+ VP+ L ++ R++G++ LD+VR+ F+
Sbjct: 132 CP--KALVAIITNPVNTCVPIAAEILKKAGVYD----PKRLFGVSTLDVVRARAFIGHAL 185
Query: 228 GFKSNTSPVIPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDEIVKA 287
G T IPVIGGHSG TI+PV S + P + D +L + R+Q G E+VKA
Sbjct: 186 GVDPQTVQ-IPVIGGHSGVTILPVLS--QSQPLFKGNQDTIEKLTV--RIQEAGTEVVKA 240
Query: 288 KNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNELRSR 347
K G GSATLSMAYAG + A + L G + I+ YV T
Sbjct: 241 KAGAGSATLSMAYAGARFAGSLLKGLNGEKNVIE--CSYVQST----------------- 281
Query: 348 YINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPICLKTLEGNIETGL 401
+ + +FS PL + +NG+++ L L+ YE+ LL + L+ NI+ G+
Sbjct: 282 -VTEATFFSTPLVLGKNGVQE--NLGLPKLNDYEK-KLLEAAIPELKKNIQKGI 331
>SPCC306.08c [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 341
Score = 195 bits (495), Expect = 1e-49
Identities = 131/357 (36%), Positives = 193/357 (53%), Gaps = 46/357 (12%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K++VLGA GGIGQ LS+LLK N L+L+D+ G AAD+ HI+T
Sbjct: 30 KVAVLGAGGGIGQPLSMLLKLN---------DKVSELALFDIR--GAPGVAADIGHINTT 78
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
+ PDD G+ + L+ A VVIIPAGVPRKPGM+RDDL NA I++ L +
Sbjct: 79 SNVVGYAPDDK--GLEKALNGADVVIIPAGVPRKPGMTRDDLFATNASIVRDLAFAAGET 136
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
C K LV++NP+NS VP+ L R + ++ +G+T LD VR+S F Q+
Sbjct: 137 CPEAKY--LVVTNPVNSTVPIFKKALERVGVHQPKHL----FGVTTLDSVRASRFTSQVT 190
Query: 228 GFKSNTSPVIPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDEIVKA 287
K+ IPV+GGHSG TI+P+ S + L R ++HR+Q+GGDE+VKA
Sbjct: 191 NGKAELLH-IPVVGGHSGATIVPLLS------QGGVELTGEKRDALIHRIQFGGDEVVKA 243
Query: 288 KNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNELRSR 347
K G GSATLSMAYAG ++A+ + L G + + + PL
Sbjct: 244 KAGAGSATLSMAYAGARMASSVLRALAGESGVEECTFVESPLYKD--------------- 288
Query: 348 YINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPICLKTLEGNIETGLKLV 404
+ +F+ +++ ++G+ IH + ++ YE ++LL + L L+ +I G + V
Sbjct: 289 --QGIDFFASRVTLGKDGVDTIH--PVGKINDYE-ESLLKVALGELKKSITKGEQFV 340
>At3g15020 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 341
Score = 189 bits (480), Expect = 6e-48
Identities = 139/358 (38%), Positives = 206/358 (56%), Gaps = 54/358 (15%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K+ +LGAAGGIGQ LSLL+K N P +S LSLYD+ G AAD+ HI+T
Sbjct: 31 KVVILGAAGGIGQPLSLLMKLN-----PLVSS----LSLYDIANTP--GVAADVGHINTR 79
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
+ + DD +G+ L A +VIIPAGVPRKPGM+RDDL +NA I+K+L IAKY
Sbjct: 80 SQVSGYMGDDD---LGKALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKNLSIAIAKY 136
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
C + V +ISNP+NS VP+ ++ + E +++G+T LD+VR+ TF +
Sbjct: 137 CP--QALVNMISNPVNSTVPIAAEIFKKA----GTYDEKKLFGVTTLDVVRARTFYAGKS 190
Query: 228 GFKSNTSPV-IPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDEIVK 286
N + V +PV+GGH+G TI+P+FS + P+ ANL D+ +R + R Q GG E+V+
Sbjct: 191 DV--NVAEVNVPVVGGHAGITILPLFS--QASPQ-ANLSDDLIR-ALTKRTQDGGTEVVE 244
Query: 287 AKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIV--MYVPLTNRNHQEIAPGSNEL 344
AK G GSATLSMAYAG A F D + + + ++V +V T
Sbjct: 245 AKAGKGSATLSMAYAG----ALFADACLKGLNGVPNVVECSFVQST-------------- 286
Query: 345 RSRYINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPICLKTLEGNIETGLK 402
I +L +F+ + + +NG++++ L L +E++ L + + L+ +IE G+K
Sbjct: 287 ----ITELPFFASKVRLGKNGVEEV--LDLGPLSDFEKEGLEALKAE-LKSSIEKGIK 337
>At3g47520 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 403
Score = 187 bits (476), Expect = 2e-47
Identities = 129/354 (36%), Positives = 194/354 (54%), Gaps = 46/354 (12%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K++VLGAAGGIGQ LSLL+K + P ++ H LYD+ + G AADLSH +TP
Sbjct: 84 KVAVLGAAGGIGQPLSLLIKMS-----PLVSTLH----LYDIAN--VKGVAADLSHCNTP 132
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
+ + S + CL + +VV+IPAGVPRKPGM+RDDL +NA I+K+L E +A+
Sbjct: 133 -SQVRDFTGPSE--LADCLKDVNVVVIPAGVPRKPGMTRDDLFNINANIVKTLVEAVAEN 189
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
C +H +ISNP+NS VP+ L + +++G+T LD+VR++TFV Q
Sbjct: 190 CPNAFIH--IISNPVNSTVPIAAEVLKKKGVYD----PKKLFGVTTLDVVRANTFVSQKK 243
Query: 228 GFKSNTSPVIPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDEIVKA 287
K +PVIGGH+G TI+P+ L + N D ++ ++ R+Q G E+V A
Sbjct: 244 NLKL-IDVDVPVIGGHAGITILPL---LSKTKPSVNFTDEEIQ-ELTVRIQNAGTEVVDA 298
Query: 288 KNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNELRSR 347
K G GSATLSMAYA + + L G+ D + + LT
Sbjct: 299 KAGAGSATLSMAYAAARFVESSLRALDGDGDVYECSFVESTLT----------------- 341
Query: 348 YINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPICLKTLEGNIETGL 401
DL +F+ + I +NG++ + L+ L YE+ L + ++ L+ +I+ G+
Sbjct: 342 ---DLPFFASRVKIGKNGLEAVIESDLQGLTEYEQKALEALKVE-LKASIDKGV 391
>CE09512 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 341
Score = 185 bits (470), Expect = 9e-47
Identities = 133/357 (37%), Positives = 194/357 (54%), Gaps = 48/357 (13%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K+++LGAAGGIGQ L LLLK + L+ H L+LYDV G AADLSHID+
Sbjct: 30 KVALLGAAGGIGQPLGLLLKQDP--LVAH-------LALYDVVNTP--GVAADLSHIDSN 78
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
TAH + + NA V++IPAGVPRKPGM+RDDL NA I++ L IAK
Sbjct: 79 AKVTAHTGPKE---LYAAVENADVIVIPAGVPRKPGMTRDDLFNTNAGIVRDLAAVIAKA 135
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
K + +I+NP+NS VP+ + L ++ RV+G+T LD+VRS FV +L
Sbjct: 136 SP--KALIAIITNPVNSTVPIASEVLKKAGVYD----PKRVFGVTTLDVVRSQAFVSELK 189
Query: 228 GFKSNTSPVIPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDEIVKA 287
G ++ + V+PV+GGH+G TIIP+ S ++ +++ + K+ R+Q G E+V A
Sbjct: 190 GHDASKT-VVPVVGGHAGITIIPLLSQVKPSTKFSEEEIS----KLTPRIQDAGTEVVNA 244
Query: 288 KNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNELRSR 347
K G GSATLSMA AG + A + + G +N Q S+ ++
Sbjct: 245 KAGAGSATLSMALAGARFANALVRGIKG---------------EKNVQCAYVASDAVKG- 288
Query: 348 YINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPICLKTLEGNIETGLKLV 404
+ YFS P+ + NG++KI + + +YE+ L+ + L NI G+ V
Sbjct: 289 ----VEYFSTPVELGPNGVEKILG--VGKVSAYEQ-KLIDASVPELNKNIAKGVAFV 338
>HsM5174541 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 338
Score = 182 bits (461), Expect = 1e-45
Identities = 120/321 (37%), Positives = 171/321 (52%), Gaps = 45/321 (14%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K++VLGA+GGIGQ LSLLLK++ RL+LYD+ G AADLSHI+T
Sbjct: 26 KVAVLGASGGIGQPLSLLLKNSP---------LVSRLTLYDIAHTP--GVAADLSHIETK 74
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
+ + + CL VV+IPAGVPRKPGM+RDDL NA I+ +L A++
Sbjct: 75 AAVKGYLGPEQ---LPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQH 131
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
C + + VI+NP+NS +P +T + + N N +++G+T LD+VR++TFV +L
Sbjct: 132 CP--EAMICVIANPVNSTIP-ITAEVFKKHGVYNPN---KIFGVTTLDIVRANTFVAELK 185
Query: 228 GFKSNTSPVIPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDEIVKA 287
G +PVIGGH+G TIIP+ S ++ + R+Q G E+VKA
Sbjct: 186 GL-DPARVNVPVIGGHAGKTIIPLISQCTPKVDF----PQDQLTALTGRIQEAGTEVVKA 240
Query: 288 KNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNELRSR 347
K G GSATLSMAYAG + +D + G ++ + QE
Sbjct: 241 KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFV-------KSQE----------- 282
Query: 348 YINDLLYFSIPLSINRNGIKK 368
+ YFS PL + + GI+K
Sbjct: 283 --TECTYFSTPLLLGKKGIEK 301
>Hs21735621 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 338
Score = 182 bits (461), Expect = 1e-45
Identities = 120/321 (37%), Positives = 171/321 (52%), Gaps = 45/321 (14%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K++VLGA+GGIGQ LSLLLK++ RL+LYD+ G AADLSHI+T
Sbjct: 26 KVAVLGASGGIGQPLSLLLKNSP---------LVSRLTLYDIAHTP--GVAADLSHIETK 74
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
+ + + CL VV+IPAGVPRKPGM+RDDL NA I+ +L A++
Sbjct: 75 AAVKGYLGPEQ---LPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQH 131
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
C + + VI+NP+NS +P +T + + N N +++G+T LD+VR++TFV +L
Sbjct: 132 CP--EAMICVIANPVNSTIP-ITAEVFKKHGVYNPN---KIFGVTTLDIVRANTFVAELK 185
Query: 228 GFKSNTSPVIPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDEIVKA 287
G +PVIGGH+G TIIP+ S ++ + R+Q G E+VKA
Sbjct: 186 GL-DPARVNVPVIGGHAGKTIIPLISQCTPKVDF----PQDQLTALTGRIQEAGTEVVKA 240
Query: 288 KNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNELRSR 347
K G GSATLSMAYAG + +D + G ++ + QE
Sbjct: 241 KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFV-------KSQE----------- 282
Query: 348 YINDLLYFSIPLSINRNGIKK 368
+ YFS PL + + GI+K
Sbjct: 283 --TECTYFSTPLLLGKKGIEK 301
>At1g53240 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 352
Score = 181 bits (460), Expect = 1e-45
Identities = 139/371 (37%), Positives = 201/371 (53%), Gaps = 69/371 (18%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K+++LGAAGGIGQ L+LL+K N P +S LSLYD+ G AAD+ HI+T
Sbjct: 31 KVAILGAAGGIGQPLALLMKLN-----PLVSS----LSLYDIANTP--GVAADVGHINTR 79
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
+ DD+ + + L A +VIIPAGVPRKPGM+RDDL +NA I+K+L IAKY
Sbjct: 80 SEVVGYMGDDN---LAKALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKNLCTAIAKY 136
Query: 168 CDLNKVHVLV--ISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQ 225
C H L+ ISNP+NS VP+ ++ E +++G+T LD+VR+ TF
Sbjct: 137 CP----HALINMISNPVNSTVPIAAEIFKKAGMYD----EKKLFGVTTLDVVRARTFY-- 186
Query: 226 LNGFKSNTSPV----IPVIGGHSGDTIIPVFSTLERD--------PEYANLLDNGMRLKM 273
K+N PV +PVIGGH+G TI+P+FS + AN L + + +
Sbjct: 187 --AGKANV-PVAEVNVPVIGGHAGVTILPLFSQVSSHFLSTQTVATPQAN-LSSDILTAL 242
Query: 274 VHRVQYGGDEIVKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIV--MYVPLTN 331
R Q GG E+V+AK G GSATLSMAYAG A F D + + + D++ YV T
Sbjct: 243 TKRTQDGGTEVVEAKAGKGSATLSMAYAG----ALFADACLKGLNGVPDVIECSYVQST- 297
Query: 332 RNHQEIAPGSNELRSRYINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPICLK 391
I +L +F+ + + +NG++++ L L +E++ L +
Sbjct: 298 -----------------ITELPFFASKVRLGKNGVEEV--LDLGPLSDFEKEGLEAL-KP 337
Query: 392 TLEGNIETGLK 402
L+ +IE G+K
Sbjct: 338 ELKSSIEKGVK 348
>7294520 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 347
Score = 171 bits (434), Expect = 1e-42
Identities = 126/360 (35%), Positives = 191/360 (53%), Gaps = 54/360 (15%)
Query: 47 LKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDT 106
LK++V+G+ GGIGQ LSLLLK N + ST LSLYD+ VG DLSHI+T
Sbjct: 28 LKVAVVGSVGGIGQPLSLLLKHNP------QIST---LSLYDIKNTTGVGV--DLSHINT 76
Query: 107 PITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAK 166
+ P + G+ + + A +V+IPAG+PRKPGM R+DL+ VNA + + ++
Sbjct: 77 RASVC---PFEGKNGLKKAMDKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASE 133
Query: 167 YCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQL 226
C + I+NPIN +VP++ T++++ + N R++G+T LD+VR+ TFV +
Sbjct: 134 VCP--GAMLAFITNPINVIVPIVA-TILKAKGTYDPN---RLFGVTTLDVVRAQTFVADI 187
Query: 227 NGFKSNTSPV---IPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDE 283
N P IPVIGGH+G TI+P+ S + DP + + R ++ R+Q G E
Sbjct: 188 ----LNVDPQKVNIPVIGGHTGRTILPILS--QCDPPFKG--TDKEREALIQRIQNAGTE 239
Query: 284 IVKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNE 343
+V AK+G GSATLSMA+A + + I + G+ D YV
Sbjct: 240 VVNAKDGLGSATLSMAFAATQFVSSLIKGIKGSKDECIVECAYV---------------- 283
Query: 344 LRSRYINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTL---LPICLKTLEGNIETG 400
+ + +F+ PL + G+K+ L +LD ER L LPI +++ I+ G
Sbjct: 284 --ESDVTEAQFFATPLILGPQGVKE--NTGLPDLDDEERKALNGMLPILKESIAKGIKLG 339
>At5g09660 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 354
Score = 171 bits (432), Expect = 2e-42
Identities = 125/361 (34%), Positives = 187/361 (51%), Gaps = 56/361 (15%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K+++LGAAGGIGQSLSLL+K N L H LYDV G AD+SH+DT
Sbjct: 44 KVAILGAAGGIGQSLSLLMKMNPLVSLLH---------LYDVVNAP--GVTADVSHMDTG 92
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
+ L+ +VIIPAG+PRKPGM+RDDL +NA I+K+L E +AK
Sbjct: 93 AVVRGFLGAKQ---LEDALTGMDLVIIPAGIPRKPGMTRDDLFKINAGIVKTLCEGVAKC 149
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
C V +ISNP+NS VP+ ++ + ++ G+T LD+ R++TFV ++
Sbjct: 150 CP--NAIVNLISNPVNSTVPIAAEVFKKA----GTYDPKKLLGVTTLDVARANTFVAEVL 203
Query: 228 GFKSNTSPVIPVIGGHSGDTIIPVFSTLER----DPEYANLLDNGMRLKMVHRVQYGGDE 283
G V PV+GGH+G TI+P+ S ++ P+ L N R+Q GG E
Sbjct: 204 GLDPREVDV-PVVGGHAGVTILPLLSQVKPPSSFTPQEIEYLTN--------RIQNGGTE 254
Query: 284 IVKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNE 343
+V+AK G GSATLSMAYA K A + L G+ + ++ +
Sbjct: 255 VVEAKAGAGSATLSMAYAAAKFADACLRGLRGDANVVECSFV------------------ 296
Query: 344 LRSRYINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPICLKTLEGNIETGLKL 403
+ + +L +F+ + + R G ++++ L L+ YER L L G+I+ G++
Sbjct: 297 --ASQVTELAFFATKVRLGRTGAEEVYQ--LGPLNEYER-IGLEKAKDELAGSIQKGVEF 351
Query: 404 V 404
+
Sbjct: 352 I 352
>At2g22780 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 354
Score = 168 bits (425), Expect = 2e-41
Identities = 119/342 (34%), Positives = 181/342 (52%), Gaps = 61/342 (17%)
Query: 48 KISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDTP 107
K+++LGAAGGIGQ L++L+K N + H LYDV G AD+SH+DT
Sbjct: 44 KVAILGAAGGIGQPLAMLMKMNPLVSVLH---------LYDVANAP--GVTADISHMDTS 92
Query: 108 ITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKY 167
+ + L+ +VIIPAGVPRKPGM+RDDL +NA I+++L E IAK
Sbjct: 93 AVVRGFLGQPQ---LEEALTGMDLVIIPAGVPRKPGMTRDDLFNINAGIVRTLSEAIAKC 149
Query: 168 CDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLN 227
C K V +ISNP+NS VP+ ++ + ++ G+T LD+VR++TFV ++
Sbjct: 150 CP--KAIVNIISNPVNSTVPIAAEVFKKA----GTFDPKKLMGVTMLDVVRANTFVAEVM 203
Query: 228 GFKSNTSPVIPVIGGHSGDTIIPVFSTL-------ERDPEYANLLDNGMRLKMVHRVQYG 280
V PV+GGH+G TI+P+ S + +++ EY + R+Q G
Sbjct: 204 SLDPREVEV-PVVGGHAGVTILPLLSQVKPPCSFTQKEIEY-----------LTDRIQNG 251
Query: 281 GDEIVKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPG 340
G E+V+AK G GSATLSMAYA + A + L G+ + ++ YV
Sbjct: 252 GTEVVEAKAGAGSATLSMAYAAVEFADACLRGLRGDANIVE--CAYV------------- 296
Query: 341 SNELRSRYINDLLYFSIPLSINRNGIKKIHYEILENLDSYER 382
+ ++ +L +F+ + + R GI +++ L L+ YER
Sbjct: 297 -----ASHVTELPFFASKVRLGRCGIDEVYG--LGPLNEYER 331
>7294521 [C] KOG1494 NAD-dependent malate dehydrogenase
Length = 349
Score = 155 bits (392), Expect = 1e-37
Identities = 122/358 (34%), Positives = 181/358 (50%), Gaps = 54/358 (15%)
Query: 47 LKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDT 106
LK++V+GA GGIGQ LSLLL+ G L+L+D+++ + G A DLSHI
Sbjct: 23 LKVAVVGAGGGIGQPLSLLLRRCPGI---------DELALHDLSE--MKGIATDLSHISQ 71
Query: 107 PITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAK 166
+ + +S A VV++ AG+PR PGM RD L+ N + + I+
Sbjct: 72 TGKVIGFTGEKE---LESAVSGADVVVVAAGMPRLPGMQRDHLMAANGNVAVKVATAISN 128
Query: 167 YCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQL 226
+ H+ I+NP+N +VP L+ A+G + R++GIT LD+VRS F+
Sbjct: 129 ASP--RAHLAFITNPVNMIVPAAAEVLM---AHGTFD-SRRLFGITTLDVVRSKKFI--- 179
Query: 227 NGFKSNTSPV---IPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGDE 283
G N SP IPVIGGH+G TI+P+ S + P Y L L HR+Q G E
Sbjct: 180 -GDSMNISPDDVNIPVIGGHAGITILPLISQCQ--PIYRCDLQEIQNL--THRIQEAGTE 234
Query: 284 IVKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVPLTNRNHQEIAPGSNE 343
+V AK G GSATLSMAYAG A F++ L+ D ++ + ++
Sbjct: 235 VVNAKAGKGSATLSMAYAG----ATFVNSLLRGIAGQDGLIECAFVASK----------- 279
Query: 344 LRSRYINDLLYFSIPLSINRNGIKKIHYEILENLDSYERDTLLPICLKTLEGNIETGL 401
+ D +F+ PL + ++GIK+ Y L + YE++ L + L L N + G+
Sbjct: 280 -----LTDAPFFASPLELGKDGIKR--YIPLPQMSDYEKEALEKL-LPILRQNADEGV 329
>At5g58330 [C] KOG1496 Malate dehydrogenase
Length = 442
Score = 57.8 bits (138), Expect = 3e-08
Identities = 66/251 (26%), Positives = 108/251 (42%), Gaps = 28/251 (11%)
Query: 44 KEILKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSH 103
K+++ I+V GAAG I S LL K +G + + ++L + + A+ G A +L
Sbjct: 96 KKLINIAVSGAAGMI--SNHLLFKLASGEVFGPDQPIALKLLGSERSIQALEGVAMELED 153
Query: 104 IDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGED 163
P+ D N + + I+ PR PGM R DL+ +N +I G+
Sbjct: 154 SLFPLLREVDIGTDPN----EVFQDVEWAILIGAKPRGPGMERADLLDINGQIFAEQGKA 209
Query: 164 IAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFV 223
+ K N V VLV+ NP N TN LI N + + +T+LD R+ +
Sbjct: 210 LNKAASPN-VKVLVVGNPCN------TNALI-CLKNAPNIPAKNFHALTRLDENRAKCQL 261
Query: 224 QQLNGFKSNTSPVIPVIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMV---HR-VQY 279
G + + + G HS + P++ N NG+ +K V H+ ++
Sbjct: 262 ALKAGVFYDKVSNMTIWGNHSTTQV----------PDFLNARINGLPVKEVITDHKWLEE 311
Query: 280 GGDEIVKAKNG 290
G E V+ + G
Sbjct: 312 GFTESVQKRGG 322
>Hs5031857 [C] KOG1495 Lactate dehydrogenase
Length = 332
Score = 57.0 bits (136), Expect = 5e-08
Identities = 85/330 (25%), Positives = 146/330 (43%), Gaps = 56/330 (16%)
Query: 48 KISVLGA-AGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSHIDT 106
KI+V+G A G+ ++S+L+K A L+L DV +D + G DL H
Sbjct: 22 KITVVGVGAVGMACAISILMKDLAD-----------ELALVDVIEDKLKGEMMDLQHGSL 70
Query: 107 PITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAK 166
+ T P +G +N+ +VII AG ++ G SR +L+ N I K + ++ K
Sbjct: 71 FLRT----PKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVK 126
Query: 167 YCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGI-TQLDLVRSSTFVQQ 225
Y K +L++SNP++ L T + +G ++RV G LD R +
Sbjct: 127 YSPNCK--LLIVSNPVDIL------TYVAWKISGFP--KNRVIGSGCNLDSAR----FRY 172
Query: 226 LNGFKSNTSPVIP---VIGGHSGDTIIPVFSTLERDPEYANLLDNGMRLKMVHRVQYGGD 282
L G + P+ V+G H GD+ +PV+S + G+ LK +H G D
Sbjct: 173 LMGERLGVHPLSCHGWVLGEH-GDSSVPVWSGMN---------VAGVSLKTLH-PDLGTD 221
Query: 283 EIVKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNT--DTIDDIVMYVPLTNRNHQEIAPG 340
+ + + AY K+ + +G + D + I+ +N + + P
Sbjct: 222 KDKEQWKEVHKQVVESAYEVIKLKG-YTSWAIGLSVADLAESIM-------KNLRRVHPV 273
Query: 341 SNELRSRY-INDLLYFSIPLSINRNGIKKI 369
S ++ Y I D ++ S+P + +NGI +
Sbjct: 274 STMIKGLYGIKDDVFLSVPCILGQNGISDL 303
>Hs4504973 [C] KOG1495 Lactate dehydrogenase
Length = 332
Score = 55.5 bits (132), Expect = 1e-07
Identities = 88/354 (24%), Positives = 146/354 (40%), Gaps = 65/354 (18%)
Query: 39 VNAQEKEILKISVLGA-AGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGT 97
+ E KI+++G A G+ ++S+LLK A L+L DV D + G
Sbjct: 13 IEDDENSQCKITIVGTGAVGMACAISILLKDLAD-----------ELALVDVALDKLKGE 61
Query: 98 AADLSHIDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKII 157
DL H +T+ ++G +N+ +VI+ AG ++ G +R L+ N I+
Sbjct: 62 MMDLQHGSLFFSTSKI----TSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIM 117
Query: 158 KSLGEDIAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGI-TQLDL 216
KS+ I Y K +LV+SNP++ L ++ + +RV G LD
Sbjct: 118 KSIIPAIVHYSPDCK--ILVVSNPVDILTYIVWKI--------SGLPVTRVIGSGCNLDS 167
Query: 217 VRSSTFVQQLNGFKSNTSPVIPVIGGHSGDTIIPVFSTLE--------RDPEYANLLDNG 268
R + + G TS +IG H GD+ +P++S + DP+ D
Sbjct: 168 ARFRYLIGEKLGVHP-TSCHGWIIGEH-GDSSVPLWSGVNVAGVALKTLDPKLGTDSDKE 225
Query: 269 MRLKMVHRVQYGGDEIVKAKNGNGSATLSMAYAGFKIAAKFIDLLVGNTDTIDDIVMYVP 328
+ +V EI+K K Y + I +DL V
Sbjct: 226 HWKNIHKQVIQSAYEIIKLK----------GYTSWAIGLSVMDL--------------VG 261
Query: 329 LTNRNHQEIAPGSNELRSRY-INDLLYFSIPLSINRNGIKKIHYEILENLDSYE 381
+N + + P S ++ Y I + L+ SIP + RNG+ + + NL+S E
Sbjct: 262 SILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDV---VKINLNSEE 312
>Hs5174539 [C] KOG1496 Malate dehydrogenase
Length = 334
Score = 53.9 bits (128), Expect = 4e-07
Identities = 67/271 (24%), Positives = 108/271 (39%), Gaps = 40/271 (14%)
Query: 45 EILKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNK--DAIVGTAADLS 102
E +++ V GAAG I SL + + + F I L L D+ + G +L
Sbjct: 3 EPIRVLVTGAAGQIAYSLLYSIGNGSVF----GKDQPIILVLLDITPMMGVLDGVLMELQ 58
Query: 103 HIDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGE 162
P+ D + + V I+ +PR+ GM R DL+ N KI KS G
Sbjct: 59 DCALPLLKDVIATDKED----VAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGA 114
Query: 163 DIAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTF 222
+ KY V V+V+ NP N TN L S + S + +T+LD R+
Sbjct: 115 ALDKYAK-KSVKVIVVGNPAN------TNCLTAS-KSAPSIPKENFSCLTRLDHNRAKAQ 166
Query: 223 VQQLNGFKSNTSPVIPVIGGHSGDTIIPVFSTLERDPEYANLL--------------DNG 268
+ G +N + + G HS ST D +A + D+
Sbjct: 167 IALKLGVTANDVKNVIIWGNHS--------STQYPDVNHAKVKLQGKEVGVYEALKDDSW 218
Query: 269 MRLKMVHRVQYGGDEIVKAKNGNGSATLSMA 299
++ + V VQ G ++KA+ + + + + A
Sbjct: 219 LKGEFVTTVQQRGAAVIKARKLSSAMSAAKA 249
>Hs21450657 [C] KOG1495 Lactate dehydrogenase
Length = 234
Score = 53.9 bits (128), Expect = 4e-07
Identities = 61/219 (27%), Positives = 106/219 (47%), Gaps = 32/219 (14%)
Query: 40 NAQEKEIL---KISVLGAAG-GIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIV 95
N E+E + KIS++G G+ ++S+LLK + L+ L DV++ +
Sbjct: 11 NFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELV-----------LVDVDEGKLK 59
Query: 96 GTAADLSHIDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAK 155
G DL H +P + + + +N+++VII AG +K G +R DL+ N
Sbjct: 60 GETMDLQH-GSPFMKMPNIVSSKDYLV---TANSNLVIITAGARQKKGETRLDLVQRNVS 115
Query: 156 IIKSLGEDIAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGI-TQL 214
I K + +I +Y K +L+++NP++ L T + +G ++RV G L
Sbjct: 116 IFKLMIPNITQYSPHCK--LLIVTNPVDIL------TYVAWKLSGFP--KNRVIGSGCNL 165
Query: 215 DLVRSSTFVQQLNGFKSNTSPVIPVIGGHSGDTIIPVFS 253
D R F+ Q G S + + ++G H GD+ +PV+S
Sbjct: 166 DSARFRYFIGQRLGIHSESCHGL-ILGEH-GDSSVPVWS 202
>CE20820 [C] KOG1496 Malate dehydrogenase
Length = 336
Score = 53.1 bits (126), Expect = 7e-07
Identities = 66/272 (24%), Positives = 106/272 (38%), Gaps = 29/272 (10%)
Query: 47 LKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNK--DAIVGTAADLSHI 104
L++ V GAAG IG S+ + + F + L L DV + + + G +L
Sbjct: 5 LRVLVTGAAGQIGYSIVIRIADGTVF----GKEQPVELVLLDVPQCSNILEGVVFELQDC 60
Query: 105 DTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDI 164
P + D + + +PR+ GM R DL+ N KI KS G+ +
Sbjct: 61 ALPTLFSVVAVTDEKSAF----TGIDYAFLVGAMPRREGMERKDLLAANVKIFKSQGKAL 116
Query: 165 AKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQ 224
A+Y V+V+ NP N TN I + +T+LD R+ +
Sbjct: 117 AEYAK-PTTKVIVVGNPAN------TNAFIAAKYAAGKIPAKNFSAMTRLDHNRALAQLA 169
Query: 225 QLNGFKSNTSPVIPVIGGHSGDTIIPV-FSTLERD----PEYANLLDNG-MRLKMVHRVQ 278
G + + G HSG V +T+ ++ YA + DN ++ + VQ
Sbjct: 170 LKTGTTIGNVKNVIIWGNHSGTQFPDVTHATVNKNGTETDAYAAVGDNAFLQGPFIATVQ 229
Query: 279 YGGDEIVKAKNGNGSATLSMAYAGFKIAAKFI 310
G I++ + LS A + K A I
Sbjct: 230 KRGGVIIEKRK------LSSAMSAAKAACDHI 255
>At5g43330 [C] KOG1496 Malate dehydrogenase
Length = 332
Score = 53.1 bits (126), Expect = 7e-07
Identities = 63/251 (25%), Positives = 104/251 (41%), Gaps = 20/251 (7%)
Query: 44 KEILKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSH 103
KE +++ V GAAG IG +L ++ G +L + + + +A+ G +L
Sbjct: 3 KEPVRVLVTGAAGQIGYALVPMIAR--GIMLGADQPVILHMLDIPFAAEALNGVKMELVD 60
Query: 104 IDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGED 163
P+ D+ + + +V ++ G PRK GM R D++ N I KS
Sbjct: 61 AAFPLLKGVVATTDAV----EACTGVNVAVMVGGFPRKEGMERKDVMSKNVSIYKSQASA 116
Query: 164 IAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFV 223
+ K+ N VLV++NP N TN LI + S E + +T+LD R+ V
Sbjct: 117 LEKHAAPN-CKVLVVANPAN------TNALILKEF-APSIPEKNITCLTRLDHNRALGQV 168
Query: 224 QQLNGFKSNTSPVIPVIGGHSG----DTIIPVFSTLERDPEYANLLDNGMRL--KMVHRV 277
+ + + + G HS D T + L+ N L + + V
Sbjct: 169 SERLSVPVSDVKNVIIWGNHSSTQYPDVNHATVKTSVGEKPVRELVKNDEWLNGEFISTV 228
Query: 278 QYGGDEIVKAK 288
Q G I+KA+
Sbjct: 229 QQRGAAIIKAR 239
>At5g56720 [C] KOG1496 Malate dehydrogenase
Length = 339
Score = 52.4 bits (124), Expect = 1e-06
Identities = 61/253 (24%), Positives = 112/253 (44%), Gaps = 22/253 (8%)
Query: 43 EKEILKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLS 102
EK+ +++ + GAAG IG +++ ++ G +L + + L + ++ +L
Sbjct: 8 EKDPIRVLITGAAGNIGYAIAPMIAR--GIMLGPDQPMILHLLDIEPASSSLEAVKMELQ 65
Query: 103 HIDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGE 162
P+ + + + + ++VI+ G PR GM R D++ N I K+
Sbjct: 66 DSAFPLLKGVI----ATTNVVEACKDVNIVIMIGGFPRIAGMERKDVMSKNVVIYKAQAS 121
Query: 163 DIAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRS-ST 221
+ +Y + VLV++NP N TN LI + S E + +T+LD R+ +
Sbjct: 122 ALERYAS-DDCKVLVVANPAN------TNALILKEF-APSIPEENITCLTRLDHNRALAQ 173
Query: 222 FVQQLNGFKSNTSPVIPVIGGHSG----DTIIPVFSTLERDPEYANLL--DNGMRLKMVH 275
+L+ S+ VI V G HS DT ST D L+ N ++ + +
Sbjct: 174 LADKLSVPVSSVKNVI-VWGNHSSTQYPDTNHATVSTKTGDRPLKELVTDHNWLKNEFIV 232
Query: 276 RVQYGGDEIVKAK 288
VQ G +++A+
Sbjct: 233 EVQQRGAAVLRAR 245
>7297683 [C] KOG1496 Malate dehydrogenase
Length = 315
Score = 52.4 bits (124), Expect = 1e-06
Identities = 55/226 (24%), Positives = 98/226 (43%), Gaps = 28/226 (12%)
Query: 128 NASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGEDIAKYCDLNKVHVLVISNPINSLVP 187
+ S + +PRK GM R DL+ N KI ++ G+ + K+ V VLV+ NP N
Sbjct: 58 DVSAAFLVGAMPRKEGMERKDLLSANVKIFRTQGQALDKFAK-KDVKVLVVGNPAN---- 112
Query: 188 LLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFVQQLNGFKSNTSPVIPVIGGHS--- 244
TN L+ S + S +T+LD R+++ + G + I + G HS
Sbjct: 113 --TNALVCS-SYAPSIPRENFSAMTRLDQNRATSQIAAKLGVPISAVKNIIIWGNHSSTQ 169
Query: 245 ----GDTIIPVFSTLERDPEYANLLDNG-MRLKMVHRVQYGGDEIVKAKNGNGSATLSMA 299
G + T++ + N DNG ++ V VQ G ++ A+ + + + + A
Sbjct: 170 YPDAGQAKVTANGTVKSVVDAIN--DNGYLQGSFVETVQKRGAAVIAARKMSSAMSAAKA 227
Query: 300 -------YAGFKIAAKFIDLLV---GNTDTIDDIVMYVPLTNRNHQ 335
+ +F+ + V G+ D+ D++ P+ +N Q
Sbjct: 228 ACDHMHDWWNGTAPGQFVSMGVFSDGSYDSPKDVIFSFPVEIKNKQ 273
>At1g04410 [C] KOG1496 Malate dehydrogenase
Length = 332
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/251 (24%), Positives = 104/251 (40%), Gaps = 20/251 (7%)
Query: 44 KEILKISVLGAAGGIGQSLSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIVGTAADLSH 103
KE +++ V GAAG IG +L ++ G +L + + + +A+ G +L
Sbjct: 3 KEPVRVLVTGAAGQIGYALVPMIAR--GIMLGADQPVILHMLDIPPAAEALNGVKMELID 60
Query: 104 IDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAKIIKSLGED 163
P+ D+ G + +V ++ G PRK GM R D++ N I KS
Sbjct: 61 AAFPLLKGVVATTDAVEGC----TGVNVAVMVGGFPRKEGMERKDVMSKNVSIYKSQAAA 116
Query: 164 IAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGITQLDLVRSSTFV 223
+ K+ N VLV++NP N TN LI + S E + +T+LD R+ +
Sbjct: 117 LEKHAAPN-CKVLVVANPAN------TNALILKEF-APSIPEKNISCLTRLDHNRALGQI 168
Query: 224 QQLNGFKSNTSPVIPVIGGHSGDTIIPV----FSTLERDPEYANLLDNGMRL--KMVHRV 277
+ + + + G HS V T + L+ + L + + V
Sbjct: 169 SERLSVPVSDVKNVIIWGNHSSSQYPDVNHAKVQTSSGEKPVRELVKDDAWLDGEFISTV 228
Query: 278 QYGGDEIVKAK 288
Q G I+KA+
Sbjct: 229 QQRGAAIIKAR 239
>SPAC186.08c [C] KOG1495 Lactate dehydrogenase
Length = 330
Score = 50.4 bits (119), Expect = 5e-06
Identities = 62/219 (28%), Positives = 96/219 (43%), Gaps = 32/219 (14%)
Query: 38 AVNAQEKEILKISVLGAAGGIGQS--LSLLLKSNAGFLLPHETSTHIRLSLYDVNKDAIV 95
+V + + +KI ++GA G +G + +LLL A ++ + D+NK
Sbjct: 12 SVRSSSFKSIKIVIVGA-GNVGSTTAFTLLLSGLAAEIV-----------IIDLNKKKAE 59
Query: 96 GTAADLSHIDTPITTTAHYPDDSNGGIGQCLSNASVVIIPAGVPRKPGMSRDDLIGVNAK 155
G A DL+H T Y D +A+ V+I AG +KPG +R DL+ N
Sbjct: 60 GEAMDLNHAAPLSHETRVYLGDYKD-----CKDATAVVITAGKNQKPGETRMDLLKANIS 114
Query: 156 IIKSLGEDIAKYCDLNKVHVLVISNPINSLVPLLTNTLIRSDANGNSNIESRVYGI-TQL 214
I K + ++ KY +LV +NP++ L T L A RV G T +
Sbjct: 115 IFKEILREVTKY--TKDAILLVATNPVDVLT-YATLKLTGFPA-------ERVIGSGTII 164
Query: 215 DLVRSSTFVQQLNGFKSNTSPVIPVIGGHSGDTIIPVFS 253
D R + +L G S +IG H GD+ + V+S
Sbjct: 165 DTARFQYLIGKLYGLDPQ-SVNADIIGEH-GDSELAVWS 201
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.137 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,224,129
Number of Sequences: 60738
Number of extensions: 1013359
Number of successful extensions: 2532
Number of sequences better than 1.0e-05: 26
Number of HSP's better than 0.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2420
Number of HSP's gapped (non-prelim): 26
length of query: 404
length of database: 30,389,216
effective HSP length: 109
effective length of query: 295
effective length of database: 23,768,774
effective search space: 7011788330
effective search space used: 7011788330
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)