ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactV2068 check: MH Q KOG1204 Secondary metabolites biosynthesis, transport and catabolism Predicted dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactV2068 726792 726235 -186
(186 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIR035c [Q] KOG1204 Predicted dehydrogenase 152 3e-37
YIR036c [Q] KOG1204 Predicted dehydrogenase 125 3e-29
SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase 100 2e-21
At3g47360 [Q] KOG1205 Predicted dehydrogenase 66 2e-11
7295622 [Q] KOG1205 Predicted dehydrogenase 66 2e-11
At3g03330 [Q] KOG1205 Predicted dehydrogenase 64 9e-11
At3g47350 [Q] KOG1205 Predicted dehydrogenase 64 2e-10
At1g10310 [R] KOG0725 Reductases with broad range of substrate s... 62 3e-10
7300831 [Q] KOG1205 Predicted dehydrogenase 62 3e-10
7292613 [Q] KOG1205 Predicted dehydrogenase 62 5e-10
Hs7705907 [R] KOG0725 Reductases with broad range of substrate s... 61 8e-10
Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 61 8e-10
At5g50700 [Q] KOG1205 Predicted dehydrogenase 61 8e-10
At5g50600 [Q] KOG1205 Predicted dehydrogenase 61 8e-10
7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 61 8e-10
Hs4502599 [Q] KOG1208 Dehydrogenases with different specificitie... 60 2e-09
At1g52340 [R] KOG0725 Reductases with broad range of substrate s... 59 3e-09
Hs5031765 [Q] KOG1205 Predicted dehydrogenase 59 4e-09
7296705 [R] KOG0725 Reductases with broad range of substrate spe... 59 5e-09
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 58 9e-09
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 57 1e-08
CE09969 [R] KOG0725 Reductases with broad range of substrate spe... 57 1e-08
Hs4502601 [Q] KOG1208 Dehydrogenases with different specificitie... 57 2e-08
At2g47140 [R] KOG0725 Reductases with broad range of substrate s... 55 7e-08
At2g47120 [R] KOG0725 Reductases with broad range of substrate s... 55 7e-08
7297069 [Q] KOG1205 Predicted dehydrogenase 54 9e-08
7292690 [Q] KOG1205 Predicted dehydrogenase 54 9e-08
CE21092 [R] KOG0725 Reductases with broad range of substrate spe... 54 1e-07
CE03613 [R] KOG1611 Predicted short chain-type dehydrogenase 54 1e-07
Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 54 2e-07
CE06649 [R] KOG0725 Reductases with broad range of substrate spe... 54 2e-07
7295621 [Q] KOG1205 Predicted dehydrogenase 54 2e-07
7290108 [R] KOG0725 Reductases with broad range of substrate spe... 53 2e-07
CE19894 [R] KOG0725 Reductases with broad range of substrate spe... 53 3e-07
7295487 [R] KOG0725 Reductases with broad range of substrate spe... 53 3e-07
YMR226c [Q] KOG1205 Predicted dehydrogenase 52 4e-07
Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 52 4e-07
SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase 52 5e-07
At2g47130 [R] KOG0725 Reductases with broad range of substrate s... 52 6e-07
HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 51 1e-06
Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 51 1e-06
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 51 1e-06
At3g26770 [R] KOG0725 Reductases with broad range of substrate s... 50 1e-06
CE26808_2 [R] KOG0725 Reductases with broad range of substrate s... 50 2e-06
Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 50 2e-06
CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 50 2e-06
At5g51030 [Q] KOG1208 Dehydrogenases with different specificitie... 50 2e-06
7300731 [Q] KOG1205 Predicted dehydrogenase 49 3e-06
YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 49 4e-06
CE12594 [R] KOG0725 Reductases with broad range of substrate spe... 49 4e-06
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 49 4e-06
At5g50690 [Q] KOG1205 Predicted dehydrogenase 49 4e-06
At5g50590 [Q] KOG1205 Predicted dehydrogenase 49 4e-06
At4g10020 [Q] KOG1205 Predicted dehydrogenase 49 4e-06
At3g29260 [R] KOG0725 Reductases with broad range of substrate s... 49 4e-06
7294452 [Q] KOG1205 Predicted dehydrogenase 49 4e-06
CE21093 [R] KOG0725 Reductases with broad range of substrate spe... 49 5e-06
At1g01800 [Q] KOG1208 Dehydrogenases with different specificitie... 49 5e-06
Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 48 7e-06
CE28291 [Q] KOG1208 Dehydrogenases with different specificities ... 48 7e-06
CE06157 [R] KOG1611 Predicted short chain-type dehydrogenase 48 7e-06
CE25799 [R] KOG1611 Predicted short chain-type dehydrogenase 48 9e-06
CE05726 [R] KOG0725 Reductases with broad range of substrate spe... 48 9e-06
At3g29250 [R] KOG0725 Reductases with broad range of substrate s... 48 9e-06
>YIR035c [Q] KOG1204 Predicted dehydrogenase
Length = 254
Score = 152 bits (384), Expect = 3e-37
Identities = 73/139 (52%), Positives = 105/139 (75%)
Query: 1 MSKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVS 60
M KV LVTGVSRGIG SIV+ L S++ +V G+ARS+ L++LK +Y +F Y+ GD++
Sbjct: 1 MGKVILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEAPLKKLKEKYGDRFFYVVGDIT 60
Query: 61 DEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGH 120
++ + + VN + ++D +VANAGVL+PV++VN I ++ WK+L+DINFFS+VSLVG
Sbjct: 61 EDSVLKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSLVGI 120
Query: 121 ALPLLKQSNGNIVLVSSGA 139
ALP LK++NGN+V VSS A
Sbjct: 121 ALPELKKTNGNVVFVSSDA 139
>YIR036c [Q] KOG1204 Predicted dehydrogenase
Length = 263
Score = 125 bits (314), Expect = 3e-29
Identities = 73/151 (48%), Positives = 99/151 (65%), Gaps = 7/151 (4%)
Query: 1 MSKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSG-KFDYICGDV 59
M KV L+TG SRGIG +V+ + + IV G+AR++ L+ L+ +Y KF Y D+
Sbjct: 1 MGKVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQREYGADKFVYRVLDI 60
Query: 60 SDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDV---NNIH-ISKWKQLFDINFFSVV 115
+D + V I K+ +LDGIVANAG+L+PV+ + N+ H I +W++LFD+NFFS+V
Sbjct: 61 TDRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFFSIV 120
Query: 116 SLVGHALPLLKQSN--GNIVLVSSGASTKSY 144
SLV LPLLK S GNIV VSSGAS K Y
Sbjct: 121 SLVALCLPLLKSSPFVGNIVFVSSGASVKPY 151
>SPBC30D10.05c [Q] KOG1204 Predicted dehydrogenase
Length = 247
Score = 99.8 bits (247), Expect = 2e-21
Identities = 58/145 (40%), Positives = 93/145 (64%), Gaps = 10/145 (6%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARS-KDKLEELKTQYSGKFDYICGDVSD 61
KV L+TG S+GIG + E L + VI ++RS +LE L Q F ++ GDV++
Sbjct: 7 KVILLTGSSKGIGLATAEAL---QKKAKVIAVSRSLTPELETLLIQNPDSFVHVKGDVTE 63
Query: 62 --EETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVG 119
+ +I A+ K+ +LD ++ NAGVL+P+ + + I++W++LFDINFFSVV V
Sbjct: 64 VGKASIETAIK----KFGKLDSVILNAGVLEPIAKIADADINEWRKLFDINFFSVVETVK 119
Query: 120 HALPLLKQSNGNIVLVSSGASTKSY 144
+A+P L+++ G IV+VSSGA+ + +
Sbjct: 120 YAIPHLRKTKGTIVIVSSGAAVRVF 144
>At3g47360 [Q] KOG1205 Predicted dehydrogenase
Length = 309
Score = 66.2 bits (160), Expect = 2e-11
Identities = 51/162 (31%), Positives = 80/162 (48%), Gaps = 9/162 (5%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLE---ELKTQY-SGKFDYICGD 58
KV L+TG S GIG + + + + +AR +D+LE E Q SG I GD
Sbjct: 48 KVVLITGASSGIGEHVAYEYA--KKGAYLALVARRRDRLEIVAETSRQLGSGNVIIIPGD 105
Query: 59 VSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
VS+ E + ++ + +LD ++ NAGV V + I + DINF+ +
Sbjct: 106 VSNVEDCKKFIDETIRHFGKLDHLINNAGVFQTVLFEDFTQIQDANPIMDINFWGTTYIT 165
Query: 119 GHALPLLKQSNGNIVLVSSGASTKSYVCIPLNFILKRRKAGL 160
A+P L++S G IV ++SG++ + +PL I KA L
Sbjct: 166 YFAIPHLRKSKGKIVAITSGSAN---IPLPLASIYAASKAAL 204
>7295622 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 66.2 bits (160), Expect = 2e-11
Identities = 43/141 (30%), Positives = 80/141 (56%), Gaps = 9/141 (6%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY----SGKFDYICGD 58
+V +VTG S GIG+++ L S IV+G+AR D+++ +K Q G+ I D
Sbjct: 7 RVAVVTGASSGIGAAVARHLVSAGV--IVVGLARRVDRMKAIKEQLPPELQGRLHAIHCD 64
Query: 59 VSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
V D +++T A ++IE + D +V NAG L+P + + + + + +Q+ ++N VV
Sbjct: 65 VEDLDSVTAAFDWIEEQLGGCDILVNNAGCLNPGQ-LLTLELEQLQQVLNVNLMGVVICT 123
Query: 119 GHALPLLKQS--NGNIVLVSS 137
A ++Q +G+++L++S
Sbjct: 124 RRAFRSMQQREVDGHVILINS 144
>At3g03330 [Q] KOG1205 Predicted dehydrogenase
Length = 345
Score = 64.3 bits (155), Expect = 9e-11
Identities = 45/148 (30%), Positives = 75/148 (50%), Gaps = 15/148 (10%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKF---------- 52
KV +TG SRGIG + ++ S++ K+++ AR+K +L+ +K++ GKF
Sbjct: 44 KVVWITGASRGIGEILAKQFASLDA-KLILS-ARNKAELDRVKSELKGKFAPEDVKVLPL 101
Query: 53 DYICGDVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFF 112
D G+ S + + +AV+ +D +V NA P ++ K FD+N F
Sbjct: 102 DLASGEESLKHVVEQAVSLFPGA--GVDYLVHNAAFERPKSKASDASEETLKTTFDVNVF 159
Query: 113 SVVSLVGHALP-LLKQSNGNIVLVSSGA 139
+SL P +LKQ G+ V++SS A
Sbjct: 160 GTISLTKLVAPHMLKQGGGHFVVISSAA 187
>At3g47350 [Q] KOG1205 Predicted dehydrogenase
Length = 308
Score = 63.5 bits (153), Expect = 2e-10
Identities = 47/142 (33%), Positives = 73/142 (51%), Gaps = 6/142 (4%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLE---ELKTQY-SGKFDYICGD 58
KV L+TG S GIG + + + K+ + +AR KD+LE E Q SG I GD
Sbjct: 47 KVVLITGASSGIGEHVAYEYAK-KGAKLAL-VARRKDRLEIVAETSRQLGSGDVIIIPGD 104
Query: 59 VSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
VS+ E + ++ + +LD ++ NAGV V + I + DINF+ +
Sbjct: 105 VSNVEDCKKFIDETIHHFGKLDHLINNAGVPQTVIFEDFTQIQDANSIMDINFWGSTYIT 164
Query: 119 GHALPLLKQSNGNIVLVSSGAS 140
A+P L++S G IV++SS +
Sbjct: 165 YFAIPHLRKSKGKIVVISSATA 186
>At1g10310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 242
Score = 62.4 bits (150), Expect = 3e-10
Identities = 43/140 (30%), Positives = 74/140 (52%), Gaps = 5/140 (3%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDY--ICGDV 59
++ L+TGVS+G+G ++ +L T VIG ARS++KL L+++ S ++ + DV
Sbjct: 17 ARTVLITGVSKGLGRALALELAKRGHT--VIGCARSQEKLTALQSELSSSTNHLLLTADV 74
Query: 60 SDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVG 119
++ E + I K D IV NAG ++ + + + + D N V +++
Sbjct: 75 KSNSSVEEMAHTIVEKKGVPDIIVNNAGTINKNSKIWEVSAEDFDNVMDTNVKGVANVLR 134
Query: 120 HALPL-LKQSNGNIVLVSSG 138
H +PL L + G IV +SSG
Sbjct: 135 HFIPLMLPRKQGIIVNMSSG 154
>7300831 [Q] KOG1205 Predicted dehydrogenase
Length = 248
Score = 62.4 bits (150), Expect = 3e-10
Identities = 46/148 (31%), Positives = 80/148 (53%), Gaps = 23/148 (15%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGK---FDYICGD 58
+KV +VTG S GIG++ +L + +V+G+AR + +E L+ Q +G F C D
Sbjct: 9 NKVAVVTGASVGIGATTAIELAN--AGMVVVGLARRVELIEALRDQVTGVGKIFARQC-D 65
Query: 59 VSDEETITEAVNFIESKYKRLDGIVANAGVL-------DPVEDVNNIHISKWKQLFDINF 111
++DEE + A N+I K++ + ++ NAG+L P +D+ K+LFD N
Sbjct: 66 LNDEEQLASAFNWIREKFQAIHVLICNAGILKANFLSESPTKDI--------KELFDTNV 117
Query: 112 FSVVSLVGHALPLLK--QSNGNIVLVSS 137
+ S + AL + + G+IV+++S
Sbjct: 118 VATASCLREALKHMAAVKVRGHIVVMNS 145
>7292613 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 62.0 bits (149), Expect = 5e-10
Identities = 44/142 (30%), Positives = 80/142 (55%), Gaps = 9/142 (6%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYS----GKFDYICG 57
++V +VTG S GIGS+I + L T V+G+AR D+++EL+ + GK +
Sbjct: 6 NRVAVVTGASSGIGSAIAKDLVLAGMT--VVGLARRVDRVKELQRELPAEKRGKLFALYC 63
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
DV +E ++ EA ++I K +D +V NAG L P V +++ + +Q+ N +V
Sbjct: 64 DVGNESSVNEAFDWIIQKLGAIDVLVNNAGTLQPGYLV-DMNPAVMQQVLQTNIMGIVLC 122
Query: 118 VGHALPLLKQS--NGNIVLVSS 137
A+ +++ +G++VL++S
Sbjct: 123 TQRAVRSMRERKFDGHVVLINS 144
>Hs7705907 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 61.2 bits (147), Expect = 8e-10
Identities = 40/135 (29%), Positives = 67/135 (49%), Gaps = 3/135 (2%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDE 62
KV +VTG RGIG+ IV + ++ S + L+ + G +C DV+ E
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRA--LEQELPGAVFILC-DVTQE 66
Query: 63 ETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGHAL 122
+ + V+ ++ RLD +V NAG P + ++QL ++N +L AL
Sbjct: 67 DDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126
Query: 123 PLLKQSNGNIVLVSS 137
P L++S GN++ +SS
Sbjct: 127 PYLRKSQGNVINISS 141
>Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 405
Score = 61.2 bits (147), Expect = 8e-10
Identities = 41/148 (27%), Positives = 69/148 (45%), Gaps = 2/148 (1%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSD 61
++ L+TG G G +KL S+ T + + + EL+T S + + D++
Sbjct: 82 TRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTK 141
Query: 62 EETITEAVNFIESKYKR--LDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVG 119
I+ + F ++ L G+V NAG + V D ++ ++ ++NFF + L
Sbjct: 142 PGDISRLLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTK 201
Query: 120 HALPLLKQSNGNIVLVSSGASTKSYVCI 147
LPLL+ S G IV V S A Y C+
Sbjct: 202 GLLPLLRSSRGRIVTVGSPAGDMPYPCL 229
>At5g50700 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 61.2 bits (147), Expect = 8e-10
Identities = 49/143 (34%), Positives = 70/143 (48%), Gaps = 8/143 (5%)
Query: 3 KVFLVTGVSRGIGSSIV-EKLCSIETTKIVIGIARSKDKLEEL----KTQYSGKFDYICG 57
KV L+TG S GIG + E C + AR K++LEE+ + S +
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALT---ARRKNRLEEVAEIARELGSPNVVTVHA 104
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
DVS + V+ + + RLD +V NAG+ N I++ K + D NF+ V
Sbjct: 105 DVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSVYT 164
Query: 118 VGHALPLLKQSNGNIVLVSSGAS 140
ALP L+QSNG IV +SS A+
Sbjct: 165 TRAALPYLRQSNGKIVAMSSSAA 187
>At5g50600 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 61.2 bits (147), Expect = 8e-10
Identities = 49/143 (34%), Positives = 70/143 (48%), Gaps = 8/143 (5%)
Query: 3 KVFLVTGVSRGIGSSIV-EKLCSIETTKIVIGIARSKDKLEEL----KTQYSGKFDYICG 57
KV L+TG S GIG + E C + AR K++LEE+ + S +
Sbjct: 48 KVVLITGASSGIGEQLAYEYACRGACLALT---ARRKNRLEEVAEIARELGSPNVVTVHA 104
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
DVS + V+ + + RLD +V NAG+ N I++ K + D NF+ V
Sbjct: 105 DVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTNFWGSVYT 164
Query: 118 VGHALPLLKQSNGNIVLVSSGAS 140
ALP L+QSNG IV +SS A+
Sbjct: 165 TRAALPYLRQSNGKIVAMSSSAA 187
>7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 242
Score = 61.2 bits (147), Expect = 8e-10
Identities = 49/144 (34%), Positives = 77/144 (53%), Gaps = 12/144 (8%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDE 62
KV LVTG GIG ++V++L S T VI +AR ++L++L + D+S
Sbjct: 8 KVILVTGAGAGIGQALVKQLASAGAT--VIAVARKPEQLQQLVAFDPVHIQPLQLDLSGW 65
Query: 63 ETITEAVNFIESKYKRLDGIVANAGV--LDPVEDVNNIHISKWKQLFDINFFSVVSLVGH 120
+ + E + +K LDG+V NAGV + P E++ + FD+N +V ++
Sbjct: 66 QAVREGL----AKVPLLDGLVNNAGVAIIKPFEELTE---QDFDTHFDVNIKAVFNVTQS 118
Query: 121 ALPLLKQSNGNIVLVSSGASTKSY 144
LP LK +IV VSS AS++S+
Sbjct: 119 LLPRLK-DGASIVNVSSIASSRSF 141
>Hs4502599 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 277
Score = 60.1 bits (144), Expect = 2e-09
Identities = 45/144 (31%), Positives = 75/144 (51%), Gaps = 8/144 (5%)
Query: 4 VFLVTGVSRGIGSSIVEKLCSIETTKIVI---GIARSKDKLEELKTQ-YSGKFDYICGDV 59
V LVTG ++GIG +IV LC + + +V+ + R + +++L+ + S +F + D+
Sbjct: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQL--DI 64
Query: 60 SDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVG 119
D ++I +F+ +Y LD +V NAG+ V D HI + NFF +
Sbjct: 65 DDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQA-EVTMKTNFFGTRDVCT 123
Query: 120 HALPLLKQSNGNIVLVSSGASTKS 143
LPL+K G +V VSS S ++
Sbjct: 124 ELLPLIK-PQGRVVNVSSIMSVRA 146
>At1g52340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 285
Score = 59.3 bits (142), Expect = 3e-09
Identities = 48/161 (29%), Positives = 80/161 (48%), Gaps = 21/161 (13%)
Query: 1 MSKVFLVTGVSRGIGSSIVE-------KLCSIETTKIVIG-IARSKDKLEELKTQYSGKF 52
+ KV L+TG + GIG SIV K+C ++ + G + +S + E +T +
Sbjct: 19 LGKVALITGGATGIGESIVRLFHKHGAKVCIVDLQDDLGGEVCKSLLRGESKETAF---- 74
Query: 53 DYICGDVSDEETITEAVNFIESKYKRLDGIVANAGVLD-PVEDVNNIHISKWKQLFDINF 111
+I GDV E+ I+ AV+F + LD ++ NAG+ P D+ N +S+++ FD+N
Sbjct: 75 -FIHGDVRVEDDISNAVDFAVKNFGTLDILINNAGLCGAPCPDIRNYSLSEFEMTFDVNV 133
Query: 112 FSVVSLVGHAL-PLLKQSNGNIVLVSS------GASTKSYV 145
+ HA ++ + G+IV + S G SYV
Sbjct: 134 KGAFLSMKHAARVMIPEKKGSIVSLCSVGGVVGGVGPHSYV 174
>Hs5031765 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 58.9 bits (141), Expect = 4e-09
Identities = 48/153 (31%), Positives = 77/153 (49%), Gaps = 21/153 (13%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY----SGKFDYICGD 58
K +VTG S+GIG + L + +V ARSK+ L+++ + + YI G
Sbjct: 35 KKVIVTGASKGIGREMAYHLAKMGAHVVVT--ARSKETLQKVVSHCLELGAASAHYIAGT 92
Query: 59 VSDEETITEAVNFIESKYKRLDGI-------VANAGVLDPVEDVNNIHISKWKQLFDINF 111
+ D +T A F+ K + G+ + N + +D++++ S ++NF
Sbjct: 93 MED---MTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKS-----MEVNF 144
Query: 112 FSVVSLVGHALPLLKQSNGNIVLVSSGASTKSY 144
S V L ALP+LKQSNG+IV+VSS A +Y
Sbjct: 145 LSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAY 177
>7296705 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 58.5 bits (140), Expect = 5e-09
Identities = 42/146 (28%), Positives = 72/146 (48%), Gaps = 7/146 (4%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFD----YICGD 58
KV +VTG S GIG+ L + ++G R+ DKL E Q + D
Sbjct: 7 KVIIVTGASSGIGAGTSVLLAKLGGLLTIVG--RNLDKLNETAEQIVAAGGAPALQVAAD 64
Query: 59 VSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
++ E + V+ +K+ R+D +V NAG+L+ + + N + ++ ++ + N S+ L
Sbjct: 65 INSESDVQGIVSATLAKHGRIDVLVNNAGILE-LGSIENTSLEQFDRVMNTNVRSLYQLT 123
Query: 119 GHALPLLKQSNGNIVLVSSGASTKSY 144
P L ++ GNIV VSS +S+
Sbjct: 124 HLVTPELIKTKGNIVNVSSVNGIRSF 149
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 57.8 bits (138), Expect = 9e-09
Identities = 38/148 (25%), Positives = 74/148 (49%), Gaps = 6/148 (4%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDY----ICGD 58
K L+TG S GIG S ++ + K+++ AR +EE+ + K++ + D
Sbjct: 7 KTILITGASSGIGKSTAFEIAKVAKVKLILA-ARRFSTVEEIAKELESKYEVSVLPLKLD 65
Query: 59 VSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
VSD ++I + + ++ +D ++ NAG+ + V +++I + N ++++
Sbjct: 66 VSDLKSIPGVIESLPKEFADIDVLINNAGLALGTDKVIDLNIDDAVTMITTNVLGMMAMT 125
Query: 119 GHALPLLKQSN-GNIVLVSSGASTKSYV 145
LP+ N G+I+ V S A +SYV
Sbjct: 126 RAVLPIFYSKNKGDILNVGSIAGRESYV 153
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 57.4 bits (137), Expect = 1e-08
Identities = 48/162 (29%), Positives = 74/162 (45%), Gaps = 12/162 (7%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY------SGKFDYIC 56
KV ++TG S GIG + L S E K+ + R+ ++LEE K G +
Sbjct: 7 KVAIITGSSNGIGQATARLLAS-EGAKVTV-TGRNAERLEETKNILLGAGVPEGNVLVVV 64
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVN---NIHISKWKQLFDINFFS 113
GD++ E + K+ ++D +V NAG P N I + + F++N S
Sbjct: 65 GDITQESVQENLIKSTLDKFGKIDILVNNAGAGIPDAQGKSGVNQSIDTYHKTFELNVQS 124
Query: 114 VVSLVGHALPLLKQSNGNIVLVSS-GASTKSYVCIPLNFILK 154
V+ + A P L ++ G IV +SS GA + V P I K
Sbjct: 125 VIEMTQKARPHLAKTQGEIVNISSIGAGPAAQVASPYYSIAK 166
>CE09969 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 57.0 bits (136), Expect = 1e-08
Identities = 46/165 (27%), Positives = 82/165 (48%), Gaps = 10/165 (6%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYI-----CG 57
+V LVT ++GIG +I ++L + + +V +R K+ ++E + + I
Sbjct: 12 RVALVTASTKGIGFAIAKQLGAAGASVVVC--SRKKENVDEAVAAL--RLENIDAHGTTA 67
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
V ++ T+ ++F ++ +LD +V+NA V D+ + S+W +L D+N S L
Sbjct: 68 HVGNKSDRTKLIDFTLDRFTKLDILVSNAAVNPHYGDLMKVTDSQWDKLLDLNVKSAFEL 127
Query: 118 VGHALPLLKQS-NGNIVLVSSGASTKSYVCIPLNFILKRRKAGLA 161
A+P L+ S GN+V VSS A I ++K GL+
Sbjct: 128 TKEAVPHLEASGRGNVVFVSSVAGYSPMNEIGAYSVMKTTLTGLS 172
>Hs4502601 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 277
Score = 56.6 bits (135), Expect = 2e-08
Identities = 42/140 (30%), Positives = 76/140 (54%), Gaps = 8/140 (5%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVI---GIARSKDKLEELKTQ-YSGKFDYICG 57
S+V LVTG +RGIG +I +LC + +V+ +AR + +++L+ + S +F +
Sbjct: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL-- 62
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
D+ D ++I +F+ +Y L+ +V NA V +D I K + NFF+ ++
Sbjct: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDI-KAEMTLKTNFFATRNM 121
Query: 118 VGHALPLLKQSNGNIVLVSS 137
LP++K +G +V +SS
Sbjct: 122 CNELLPIMK-PHGRVVNISS 140
>At2g47140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 54.7 bits (130), Expect = 7e-08
Identities = 37/142 (26%), Positives = 71/142 (49%), Gaps = 7/142 (4%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSG--KFDYICGDVS 60
K+ ++TG + GIG+ V +++ + +D+L + G K Y DV+
Sbjct: 16 KIVIITGGASGIGAESVRLFTEHGARVVIVDV---QDELGQNVAVSIGEDKASYYHCDVT 72
Query: 61 DEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGH 120
+E + AV F KY +LD + +NAGV++P + ++++++ + IN + + H
Sbjct: 73 NETEVENAVKFTVEKYGKLDVLFSNAGVIEPFVSILDLNLNELDRTIAINLRGTAAFIKH 132
Query: 121 ALPLL--KQSNGNIVLVSSGAS 140
A + K G+IV +S A+
Sbjct: 133 AARAMVEKGIRGSIVCTTSVAA 154
>At2g47120 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 54.7 bits (130), Expect = 7e-08
Identities = 39/142 (27%), Positives = 72/142 (50%), Gaps = 13/142 (9%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYS-----GKFDYICG 57
K+ ++TG + GIG+ +L + K+VI D EEL + K +
Sbjct: 9 KIVIITGGASGIGADAA-RLFTDHGAKVVI-----VDVQEELGQNVAVLIGKDKASFYRC 62
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
DV++E + +AV F K+ +LD + +NAGVL+P+E + + ++ ++ +N +
Sbjct: 63 DVTNETEVEDAVKFTVEKHGKLDVLFSNAGVLEPLESFLDFDLERFDRIMAVNVRGAAAF 122
Query: 118 VGHALPLL--KQSNGNIVLVSS 137
+ HA + K + G+IV +S
Sbjct: 123 IKHAARAMVEKGTRGSIVCTTS 144
>7297069 [Q] KOG1205 Predicted dehydrogenase
Length = 246
Score = 54.3 bits (129), Expect = 9e-08
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 13/157 (8%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKT----QYSGKFDYICG 57
+K+ +VTG S GIG++ + I V+G+AR + KL+EL+ + F
Sbjct: 6 NKLAVVTGASGGIGAACARAM--IGAGLRVVGLARREAKLKELRESLPRELQANFIPRRC 63
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
DVS E+ + + ++IE + + D ++ NAG+ E V + K K++ D N V+
Sbjct: 64 DVSKEDQVQSSFDWIERELEGADVLLNNAGITRETELVTPSNTQKLKEVIDTNVMGVIWC 123
Query: 118 VGHALPLLKQ--SNGNIVLVSSGASTKSYVCIPLNFI 152
A +K+ G++++++S A + LNFI
Sbjct: 124 TREAFNNMKRRGGEGHVLIINSIAGHQ-----VLNFI 155
>7292690 [Q] KOG1205 Predicted dehydrogenase
Length = 251
Score = 54.3 bits (129), Expect = 9e-08
Identities = 44/147 (29%), Positives = 78/147 (52%), Gaps = 10/147 (6%)
Query: 1 MSKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELK----TQYSGKFDYIC 56
+++V +VTG S GIG++ + L S +V+G+AR +D+L+ELK + +F
Sbjct: 5 LNRVAVVTGASSGIGAACCKDLVS--KGLVVVGLARREDRLQELKASLPADQASRFHGRK 62
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAGVLD-PVEDVNNIHISKWKQLFDINFFSVV 115
DVS E+ + +A +I++ D +V NAG++ V + + + + + D N V
Sbjct: 63 CDVSQEQEVIDAFAWIDATLGGADVLVNNAGIVRLGVGITHEGNGADLRAILDTNVLGVS 122
Query: 116 SLVGHALPLLKQSN---GNIVLVSSGA 139
A LK+ N G+I++V+S A
Sbjct: 123 WCTREAFKSLKRRNVNDGHILIVNSVA 149
>CE21092 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 53.9 bits (128), Expect = 1e-07
Identities = 45/147 (30%), Positives = 71/147 (47%), Gaps = 11/147 (7%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY------SGKFDYIC 56
KV ++TG S GIG S L E K+ + RS +K++E + S + +
Sbjct: 7 KVAIITGSSSGIGRSTAVLLAQ-EGAKVTV-TGRSSEKIQETVNEIHKNGGSSDNINIVL 64
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAGVL--DPVEDVNN-IHISKWKQLFDINFFS 113
GD+++ E E + S++ ++D ++ NAG DP + + I + + +N S
Sbjct: 65 GDLNESECQDELIKSTLSRFGKIDILINNAGAAFADPSGKIGSEAAIGIFDDMMKLNLRS 124
Query: 114 VVSLVGHALPLLKQSNGNIVLVSSGAS 140
VV LV P L S G IV VSS A+
Sbjct: 125 VVELVKKCRPHLIASKGEIVNVSSIAA 151
>CE03613 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 262
Score = 53.9 bits (128), Expect = 1e-07
Identities = 38/142 (26%), Positives = 69/142 (47%), Gaps = 4/142 (2%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELK--TQYSGKFDYICGDVS 60
K +TG +RGIG IV KL + +++I AR+ + EL+ + + I DV+
Sbjct: 4 KTVFITGANRGIGLGIVRKLLKVSEIEVIIAGARNLEAANELRELAKADNRLHAITVDVA 63
Query: 61 DEETITEAVNFIESKY--KRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
++E + +V +ES + L+ ++ NAG + E ++ + FD+N +
Sbjct: 64 NDERLANSVKQVESLVGDRGLNLLINNAGCYELYETTDSPSRKASLKCFDVNAVGSLMAS 123
Query: 119 GHALPLLKQSNGNIVLVSSGAS 140
LPLLK++ + + AS
Sbjct: 124 QLFLPLLKKAAAHTHITGLSAS 145
>Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 387
Score = 53.5 bits (127), Expect = 2e-07
Identities = 39/137 (28%), Positives = 67/137 (48%), Gaps = 2/137 (1%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDE 62
K LVTG G+G ++ + L + T + + EEL+ S + + D++
Sbjct: 83 KAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKP 142
Query: 63 ETITEAVNFIESKY--KRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGH 120
I +A + + + + L ++ NAGVL D + ++ +KQ +NFF V +
Sbjct: 143 VQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKT 202
Query: 121 ALPLLKQSNGNIVLVSS 137
LPLL++S G +V VSS
Sbjct: 203 FLPLLRKSKGRLVNVSS 219
>CE06649 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 53.5 bits (127), Expect = 2e-07
Identities = 49/166 (29%), Positives = 83/166 (49%), Gaps = 26/166 (15%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKT---QYSGK-FDYI--C 56
KV L++G S+GIG + K + E KIV+ RS D +E+ + + K +D +
Sbjct: 9 KVVLISGSSKGIGQATAVKFAA-EGAKIVLN-GRSADDVEKTRKLCMEVGAKPWDLLPTV 66
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDI------- 109
GD+++E+ + VN + + +LD ++ NAG L +V+ W+ D+
Sbjct: 67 GDITNEDFVKMMVNTVIHNFGKLDILINNAGTL----EVDMTGKEGWEMGVDVMDRSWNS 122
Query: 110 NFFSVVSLVGHALPLLKQSNGNIVLVSS-------GASTKSYVCIP 148
NF SV+ L A+P L ++ G+IV VS+ G + Y +P
Sbjct: 123 NFKSVLMLTQAAMPHLIKTKGDIVNVSTFLSSGPIGVMSMPYYAVP 168
>7295621 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 53.5 bits (127), Expect = 2e-07
Identities = 39/140 (27%), Positives = 71/140 (49%), Gaps = 9/140 (6%)
Query: 4 VFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY----SGKFDYICGDV 59
V +VTG S GIG++I KL I +V+ +AR D+LE+L+ + + + DV
Sbjct: 8 VAVVTGASSGIGAAITRKL--ISAGVMVVALARRMDRLEQLREELPQDRRSRLRIMQCDV 65
Query: 60 SDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVG 119
SD ++ + ++ +D ++ NAG L + + + + +Q+ N VV
Sbjct: 66 SDVSSVNAVFDAVQGDLGNVDILINNAGKLSGGQ-LLTMSVDTVQQMLQTNVMGVVYCTQ 124
Query: 120 HALPLL--KQSNGNIVLVSS 137
A + +QS G++VL++S
Sbjct: 125 RAFESMRQRQSKGHVVLINS 144
>7290108 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 53.1 bits (126), Expect = 2e-07
Identities = 43/145 (29%), Positives = 75/145 (51%), Gaps = 8/145 (5%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSG-KFDYICGDVS 60
+KV +VTG S GIG++I + L T ++G R+ LE K G + + + DV+
Sbjct: 5 NKVVIVTGASSGIGAAIAQVLAREGATLALVG--RNVANLEATKKSLKGTQAEIVVADVT 62
Query: 61 -DEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVG 119
D + I + +K+ R+D +V NAG+L + ++ I ++ + + N V+ L
Sbjct: 63 KDADAIVQQT---LAKFGRIDVLVNNAGILGK-GGLIDLDIEEFDAVLNTNLRGVILLTK 118
Query: 120 HALPLLKQSNGNIVLVSSGASTKSY 144
LP L ++ G +V VSS A + +
Sbjct: 119 AVLPHLLKTKGAVVNVSSCAGIRPF 143
>CE19894 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 52.8 bits (125), Expect = 3e-07
Identities = 42/162 (25%), Positives = 76/162 (45%), Gaps = 5/162 (3%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSK---DKLEELKTQYSGKFDYICGDV 59
KV +VT ++GIG +I E+L E +VIG K + +E LK + K I G +
Sbjct: 11 KVAIVTAATKGIGLAIAERLLD-EGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAGHI 69
Query: 60 SDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVG 119
+ + + V+F K+ +++ +V N G+ + + W +LF++N + +
Sbjct: 70 ASTDDQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQMTK 129
Query: 120 HALP-LLKQSNGNIVLVSSGASTKSYVCIPLNFILKRRKAGL 160
P + K+ G I+ +S ++ KS I + K GL
Sbjct: 130 LVHPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGL 171
>7295487 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 317
Score = 52.8 bits (125), Expect = 3e-07
Identities = 49/162 (30%), Positives = 75/162 (46%), Gaps = 6/162 (3%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKD---KLEELKTQYSGKFDYICGDV 59
KV +VT + GIG +I ++L + +VI + K+ L EL+ C V
Sbjct: 72 KVAVVTASTDGIGFAIAKRLAE-DGAAVVISSRKQKNVDSALAELRKLNLNVHGLKC-HV 129
Query: 60 SDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVG 119
S+ E + SK+ +L+ +V+NA V V W ++FD+N S L
Sbjct: 130 SEPEDRKQLFEETISKFGKLNILVSNAATNPAVGGVLECDEKVWDKIFDVNVKSSYLLAK 189
Query: 120 HALPLLK-QSNGNIVLVSSGASTKSYVCIPLNFILKRRKAGL 160
ALPLL+ Q N +IV VSS A ++ + + K GL
Sbjct: 190 EALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGL 231
>YMR226c [Q] KOG1205 Predicted dehydrogenase
Length = 267
Score = 52.4 bits (124), Expect = 4e-07
Identities = 43/149 (28%), Positives = 74/149 (48%), Gaps = 7/149 (4%)
Query: 3 KVFLVTGVSRGIG-SSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFD----YICG 57
K L+TG S GIG ++ +E L + +I AR +KLEELK +F ++
Sbjct: 14 KTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHVAQ 73
Query: 58 -DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVS 116
D++ E I + + ++K +D +V NAG + V I + +FD N ++++
Sbjct: 74 LDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTALIN 133
Query: 117 LVGHALPLLKQSN-GNIVLVSSGASTKSY 144
+ LP+ + N G+IV + S A +Y
Sbjct: 134 ITQAVLPIFQAKNSGDIVNLGSIAGRDAY 162
>Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 52.4 bits (124), Expect = 4e-07
Identities = 35/137 (25%), Positives = 67/137 (48%), Gaps = 4/137 (2%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDE 62
K +TG G G+ + +L + V+ ++ E+L+ Q S + + + DV+
Sbjct: 30 KYVFITGCDSGFGNLLARQLDARGLR--VLAACLTEKGAEQLRGQTSDRLETVTLDVTKM 87
Query: 63 ETITEAVNFIESKY--KRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGH 120
E+I A +++ + L G+V NAG+L P+ ++ + +N V+ +
Sbjct: 88 ESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLS 147
Query: 121 ALPLLKQSNGNIVLVSS 137
LPL++++ G IV VSS
Sbjct: 148 MLPLVRRARGRIVNVSS 164
>SPCC663.06c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 52.0 bits (123), Expect = 5e-07
Identities = 36/151 (23%), Positives = 66/151 (42%), Gaps = 3/151 (1%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELK--TQYSGKFDYICGDV 59
+K++ + G +RGIG S+V++L + E T +V AR + EL+ ++ I D+
Sbjct: 5 NKIYFIAGGNRGIGLSLVKELSNREGT-VVFASARKPEAATELQEWSKSHSNVHIIKLDI 63
Query: 60 SDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVG 119
S E+ EA + ++D + N+G+ V N W + N + +
Sbjct: 64 SSLESANEAAQEVAKAVGKVDVLWVNSGIFHSFNTVLNTPDDVWNSHYKTNVLGPIHVYQ 123
Query: 120 HALPLLKQSNGNIVLVSSGASTKSYVCIPLN 150
PL+K+ I++ +S P N
Sbjct: 124 AFYPLVKKGESKIIVFTSSLVGSMGAFFPFN 154
>At2g47130 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 51.6 bits (122), Expect = 6e-07
Identities = 40/145 (27%), Positives = 73/145 (49%), Gaps = 13/145 (8%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYS-----GKFDYICG 57
K+ ++TG + GIG+ V +L + K+VI D EEL + K +
Sbjct: 9 KIAIITGGASGIGAEAV-RLFTDHGAKVVI-----VDFQEELGQNVAVSVGKDKASFYRC 62
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
DV++E+ + AV F KY +LD + +NAGV++ ++++ ++ + +N +
Sbjct: 63 DVTNEKEVENAVKFTVEKYGKLDVLFSNAGVMEQPGSFLDLNLEQFDRTMAVNVRGAAAF 122
Query: 118 VGHALPLL--KQSNGNIVLVSSGAS 140
+ HA + K + G+IV +S AS
Sbjct: 123 IKHAARAMVEKGTRGSIVCTTSVAS 147
>HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 50.8 bits (120), Expect = 1e-06
Identities = 34/137 (24%), Positives = 66/137 (47%), Gaps = 4/137 (2%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDE 62
K +TG G G + +L + V+ ++ E+L+ Q S + + + DV+
Sbjct: 30 KYVFITGCDSGFGKLLARQLDARGLR--VLAACLTEKGAEQLRGQTSDRLETVTLDVTKT 87
Query: 63 ETITEAVNFIES--KYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGH 120
E++ A +++ + K L G+V NAG+ P + + + D+N V+ +
Sbjct: 88 ESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLS 147
Query: 121 ALPLLKQSNGNIVLVSS 137
LPL++++ G +V VSS
Sbjct: 148 LLPLVRKARGRVVNVSS 164
>Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 343
Score = 50.8 bits (120), Expect = 1e-06
Identities = 38/142 (26%), Positives = 68/142 (47%), Gaps = 7/142 (4%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSK--DKLEELKTQYSGKFDYICGDV 59
SK LVTG G G S+ + L S + + K D ++EL + S + + +V
Sbjct: 55 SKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNV 114
Query: 60 SDEETITEAVNFIESKYKRLD----GIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVV 115
E + + V + S K + G+V NAG+ +V + +KQ+ ++N + V
Sbjct: 115 CSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNLWGTV 173
Query: 116 SLVGHALPLLKQSNGNIVLVSS 137
+ LPL++++ G +V +SS
Sbjct: 174 RMTKSFLPLIRRAKGRVVNISS 195
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 50.8 bits (120), Expect = 1e-06
Identities = 50/145 (34%), Positives = 72/145 (49%), Gaps = 13/145 (8%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY--SGKFD----YIC 56
KV LVTG S GIG + L E K+ I R+ D+LEE + + SG + I
Sbjct: 7 KVALVTGSSNGIGRATAVLLAQ-EGAKVTI-TGRNADRLEETRQEILKSGVPEDHVLSIA 64
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNI----HISKWKQLFDINFF 112
D++ E+ E VN K+ RLD +V NAG +D + +S + ++ IN
Sbjct: 65 TDLATEKGQDELVNSTIQKFGRLDILVNNAGAAFN-DDQGRVGVDQDVSVYDRIMQINMR 123
Query: 113 SVVSLVGHALPLLKQSNGNIVLVSS 137
SVV+L A L ++ G +V VSS
Sbjct: 124 SVVTLTQKAKEHLVKAKGEVVNVSS 148
>At3g26770 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 50.4 bits (119), Expect = 1e-06
Identities = 33/140 (23%), Positives = 71/140 (50%), Gaps = 4/140 (2%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDE 62
KV L+TG + G+G + + ++VI ++ + K + + +++ DV+ E
Sbjct: 18 KVALITGGASGLGKATASEFLR-HGARVVIADLDAETGTKTAK-ELGSEAEFVRCDVTVE 75
Query: 63 ETITEAVNFIESKYKRLDGIVANAGVLDPV--EDVNNIHISKWKQLFDINFFSVVSLVGH 120
I AV +Y +LD + NAG++ P+ ++ + +++++++ IN F VVS + H
Sbjct: 76 ADIAGAVEMTVERYGKLDVMYNNAGIVGPMTPASISQLDMTEFERVMRINVFGVVSGIKH 135
Query: 121 ALPLLKQSNGNIVLVSSGAS 140
A + + +L +S +
Sbjct: 136 AAKFMIPARSGCILCTSSVA 155
>CE26808_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 550
Score = 50.1 bits (118), Expect = 2e-06
Identities = 48/144 (33%), Positives = 73/144 (50%), Gaps = 11/144 (7%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY------SGKFDYIC 56
KV LVTG S GIG + L + + K+ I R+ ++LEE + + I
Sbjct: 222 KVALVTGSSNGIGRAAA-LLFAQQGAKVTI-TGRNAERLEETRQAILKSGVPAENVLAIA 279
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAG--VLDPVEDVN-NIHISKWKQLFDINFFS 113
D++ ++ T+ +N K+ RLD +V NAG V DP + + I + + F IN S
Sbjct: 280 ADLATDQGQTDLINGTLQKFGRLDILVNNAGAAVNDPQGRMGIDQQIEDFDKTFQINMRS 339
Query: 114 VVSLVGHALPLLKQSNGNIVLVSS 137
VV+LV A L ++ G I+ VSS
Sbjct: 340 VVTLVQKAKEHLIKTKGEIINVSS 363
>Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 319
Score = 49.7 bits (117), Expect = 2e-06
Identities = 32/137 (23%), Positives = 67/137 (48%), Gaps = 4/137 (2%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDE 62
K +TG G G+ + VI ++ LK + S + + DV+D
Sbjct: 30 KYIFITGCDSGFGNLAARTFD--KKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDP 87
Query: 63 ETITEAVNFIESKY--KRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGH 120
E + +++++ K L G++ NAGV + + + + +++ ++N F ++S+ +
Sbjct: 88 ENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLN 147
Query: 121 ALPLLKQSNGNIVLVSS 137
LPL+K++ G ++ VSS
Sbjct: 148 MLPLVKKAQGRVINVSS 164
>CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 258
Score = 49.7 bits (117), Expect = 2e-06
Identities = 38/150 (25%), Positives = 70/150 (46%), Gaps = 13/150 (8%)
Query: 4 VFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDEE 63
V LVTG + G+G E L ++ + +SK ++ + G F V+ EE
Sbjct: 11 VALVTGGASGLGKGAAEVLAKAGAQVAILDLPQSKGA--DVAKEIGGIFTP--ASVTSEE 66
Query: 64 TITEAVNFIESKYKRLDGIVANAGV-----LDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
+ A ++++Y RLD +V AG+ L V+ ++ K +Q D+N +++
Sbjct: 67 EVRAAFAKVQAEYGRLDALVNCAGIAYAFKLYSVQKKKHVDFEKIRQTIDVNVLGTFNVI 126
Query: 119 GHALPLL----KQSNGNIVLVSSGASTKSY 144
H + L+ K +NG +V + AS ++
Sbjct: 127 RHGVALMGEHEKDANGQRGVVINTASVAAF 156
>At5g51030 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 314
Score = 49.7 bits (117), Expect = 2e-06
Identities = 41/141 (29%), Positives = 70/141 (49%), Gaps = 13/141 (9%)
Query: 4 VFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDK---LEELKTQYSGKF--DYICGD 58
V +VTG +RGIG +V +L T I+ S+D+ +E K G F D+ D
Sbjct: 39 VAVVTGANRGIGFEMVRQLAGHGLTVILT----SRDENVGVEAAKILQEGGFNVDFHRLD 94
Query: 59 VSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
+ D +I E +I+ KY +D ++ NAGV V N++ S + N++ +++
Sbjct: 95 ILDSSSIQEFCEWIKEKYGFIDVLINNAGVNYNVGSDNSVEFS--HMVISTNYYGTKNII 152
Query: 119 GHALPLLKQS--NGNIVLVSS 137
+PL++ + IV V+S
Sbjct: 153 NAMIPLMRHACQGARIVNVTS 173
>7300731 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 49.3 bits (116), Expect = 3e-06
Identities = 34/144 (23%), Positives = 75/144 (51%), Gaps = 9/144 (6%)
Query: 1 MSKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY----SGKFDYIC 56
+++V +VTG S GIG++ L + +V+G+AR + L+++K+ + +F
Sbjct: 5 LNRVAVVTGASAGIGAACCRDL--VAKGMVVVGLARREKVLQDIKSSLPADQAARFHTRP 62
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVS 116
DVS+E+ + + +I+ D +V NAG++ + + + + + + D+N V
Sbjct: 63 CDVSNEQQVIDTFAWIDRTLGGADVLVNNAGIIRQMNITDPENSADVRAILDVNVLGVTW 122
Query: 117 LVGH---ALPLLKQSNGNIVLVSS 137
+L K ++G++V+++S
Sbjct: 123 CTRQWFLSLQRRKVNDGHVVVINS 146
>YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 326
Score = 48.9 bits (115), Expect = 4e-06
Identities = 32/121 (26%), Positives = 58/121 (47%), Gaps = 7/121 (5%)
Query: 4 VFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDEE 63
+ L+TG S+G+G +IV +L + ++ + + + + D IC D+SD+E
Sbjct: 72 IVLITGGSKGLGRAIVSQLLQDYSNLTILNVDICPSSVRNTRVK-----DLIC-DLSDDE 125
Query: 64 TITEAVNFIESKYK-RLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGHAL 122
+ +N ++ KYK + IV NAGV N + ++F IN F+ + +
Sbjct: 126 EVAALLNLLKRKYKNEIRLIVNNAGVRANFTGFNGMERDNLDKIFKINTFAPLQFIQELA 185
Query: 123 P 123
P
Sbjct: 186 P 186
>CE12594 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 48.9 bits (115), Expect = 4e-06
Identities = 41/143 (28%), Positives = 70/143 (48%), Gaps = 11/143 (7%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY------SGKFDYIC 56
K ++TG S GIG S + + E ++ I RS D+LEE + Q + K + +
Sbjct: 7 KSIIITGSSSGIGRSAAV-IFAKEGAQVTI-TGRSADRLEETRLQILKAGVPAEKINAVV 64
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAGVL--DPVEDVNNIHISKWKQLFDINFFSV 114
DV + E + +K+ ++D +V NAG L D + + + +++ F +NF +V
Sbjct: 65 ADVCEASGQDEVIRTTLAKFGKIDILVNNAGALLTDGTSNTDQA-VELYQKTFKLNFQAV 123
Query: 115 VSLVGHALPLLKQSNGNIVLVSS 137
V + L ++ G IV VSS
Sbjct: 124 VEMTQKTKEYLIKTKGEIVNVSS 146
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 48.9 bits (115), Expect = 4e-06
Identities = 43/147 (29%), Positives = 68/147 (46%), Gaps = 11/147 (7%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSG------KFDYIC 56
KV ++TG S GIG + L + E K+ I R ++LEE + Q + +
Sbjct: 7 KVAIITGSSNGIGRATAV-LFAREGAKVTI-TGRHAERLEETRQQILAAGVSEQNVNSVV 64
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNN---IHISKWKQLFDINFFS 113
DV+ + E ++ K+ +LD +V NAG P I + ++N S
Sbjct: 65 ADVTTDAGQDEILSTTLGKFGKLDILVNNAGAAIPDSQSKTGTAQSIESYDATLNLNLRS 124
Query: 114 VVSLVGHALPLLKQSNGNIVLVSSGAS 140
V++L A+P L + G IV +SS AS
Sbjct: 125 VIALTKKAVPHLSSTKGEIVNISSIAS 151
>At5g50690 [Q] KOG1205 Predicted dehydrogenase
Length = 303
Score = 48.9 bits (115), Expect = 4e-06
Identities = 50/189 (26%), Positives = 81/189 (42%), Gaps = 11/189 (5%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY----SGKFDYICGD 58
KV ++TG S GIG + + + +AR +D+L+ + + S + GD
Sbjct: 48 KVVIITGSSSGIGEHLAYEYA--RRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGD 105
Query: 59 VSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
VS + V S++ RLD +V NAG+ + + IS + + NF+ V
Sbjct: 106 VSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGPVYAT 165
Query: 119 GHALPLLKQSNGNIVLVSSGASTKSYVCIPLNFILKRRKAGLA--YGRTRFTNQNSSQNS 176
A+P LK++ G I+ V+S A +P I KA + Y R +
Sbjct: 166 HFAIPHLKKTKGKIIAVASPAGWSG---VPRMSIYAASKAAMINFYETLRIELHPEVGVT 222
Query: 177 TCFQGNVEN 185
F G +EN
Sbjct: 223 IVFPGLIEN 231
>At5g50590 [Q] KOG1205 Predicted dehydrogenase
Length = 299
Score = 48.9 bits (115), Expect = 4e-06
Identities = 50/189 (26%), Positives = 81/189 (42%), Gaps = 11/189 (5%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY----SGKFDYICGD 58
KV ++TG S GIG + + + +AR +D+L+ + + S + GD
Sbjct: 48 KVVIITGSSSGIGEHLAYEYA--RRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGD 105
Query: 59 VSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
VS + V S++ RLD +V NAG+ + + IS + + NF+ V
Sbjct: 106 VSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLPIVNTNFWGPVYAT 165
Query: 119 GHALPLLKQSNGNIVLVSSGASTKSYVCIPLNFILKRRKAGLA--YGRTRFTNQNSSQNS 176
A+P LK++ G I+ V+S A +P I KA + Y R +
Sbjct: 166 HFAIPHLKKTKGKIIAVASPAGWSG---VPRMSIYAASKAAMINFYETLRIELHPEVGVT 222
Query: 177 TCFQGNVEN 185
F G +EN
Sbjct: 223 IVFPGLIEN 231
>At4g10020 [Q] KOG1205 Predicted dehydrogenase
Length = 389
Score = 48.9 bits (115), Expect = 4e-06
Identities = 51/175 (29%), Positives = 81/175 (46%), Gaps = 19/175 (10%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYI--CGDVS 60
KV ++TG S IG I + +++ + ++ K + G I DV
Sbjct: 50 KVVVITGASSAIGEQIAYEYAKRGANLVLVARREQRLRVVSNKAKQIGANHVIIIAADVI 109
Query: 61 DEET----ITEAVNFIESKYKRLDGIV--ANAGVLDPVEDVNNIHISKWKQLFDINFFSV 114
E+ IT+AVN+ Y R+D +V A+ G E+V++ + + L DINF+
Sbjct: 110 KEDDCRRFITQAVNY----YGRVDHLVNTASLGHTFYFEEVSDTTV--FPHLLDINFWGN 163
Query: 115 VSLVGHALPLLKQSNGNIVLVSSGASTKSYVCIPLNFILKRRKAGLA--YGRTRF 167
V ALP L Q+NG IV+ AS ++++ +P + KA L Y RF
Sbjct: 164 VYPTYVALPYLHQTNGRIVV---NASVENWLPLPRMSLYSAAKAALVNFYETLRF 215
>At3g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 259
Score = 48.9 bits (115), Expect = 4e-06
Identities = 37/142 (26%), Positives = 68/142 (47%), Gaps = 13/142 (9%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYS-----GKFDYICG 57
K+ ++TG + GIG+ +L + K+VI D EEL + K +
Sbjct: 9 KIVIITGGASGIGAEAA-RLFTDHGAKVVI-----VDLQEELGQNVAVSIGLDKASFYRC 62
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
D++DE + AV F K+ +LD + +NAGV++P + ++ + + + +N +
Sbjct: 63 DITDETEVENAVKFTVEKHGKLDVLFSNAGVMEPHGSILDLDLEAFDRTMAVNVRGAAAF 122
Query: 118 VGHALPLLKQS--NGNIVLVSS 137
+ HA + S G+IV +S
Sbjct: 123 IKHAARSMVASGTRGSIVCTTS 144
>7294452 [Q] KOG1205 Predicted dehydrogenase
Length = 266
Score = 48.9 bits (115), Expect = 4e-06
Identities = 37/144 (25%), Positives = 74/144 (50%), Gaps = 8/144 (5%)
Query: 2 SKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYS----GKFDYICG 57
+KV +V+G S GIG++ L I IV+G+AR +++E+L++ S + I
Sbjct: 20 NKVAVVSGASAGIGAACTRAL--IGAGMIVVGLARRHERVEKLRSGLSLEQQSRLHAIKC 77
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
D++ E+ + +A ++ + +D +V+NAG++ E + + N V
Sbjct: 78 DITQEDQVLKAFDWTCRQLGGVDVLVSNAGIIGTGELSERDDGPAMRSTIETNIMGTVYC 137
Query: 118 VGHALPLLKQ--SNGNIVLVSSGA 139
V + +K+ + G++V+V+S A
Sbjct: 138 VRESFRSMKRRGTEGHVVIVNSVA 161
>CE21093 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 281
Score = 48.5 bits (114), Expect = 5e-06
Identities = 49/149 (32%), Positives = 75/149 (49%), Gaps = 13/149 (8%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY--SGKFDY----IC 56
KV LVTG S GIG + L + + K+ + R+ ++LEE + + SG + +
Sbjct: 8 KVALVTGSSNGIGRAAAV-LFAKDGAKVTV-TGRNAERLEETRQEILKSGVPESHVLSVA 65
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNI----HISKWKQLFDINFF 112
D++ E+ E VN K+ RLD +V NAG +D + +S + ++ IN
Sbjct: 66 TDLAAEKGQDELVNSTIQKFGRLDILVNNAGAAFN-DDQGRVGVDQDVSVYDKIMQINMR 124
Query: 113 SVVSLVGHALPLLKQSNGNIVLVSSGAST 141
SVV+L A L ++ G IV VSS A T
Sbjct: 125 SVVTLTQKAKEHLVKAKGEIVNVSSIAGT 153
>At1g01800 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 309
Score = 48.5 bits (114), Expect = 5e-06
Identities = 45/149 (30%), Positives = 82/149 (54%), Gaps = 15/149 (10%)
Query: 1 MSKVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDK----LEELKTQYSGKFDYIC 56
+S+V +VTG ++GIG I +L + T V+ AR ++K +++LKT+ +G D
Sbjct: 33 VSRVAVVTGSNKGIGFEICRQLANNGIT--VVLTARDENKGLAAVQKLKTE-NGFSDQAI 89
Query: 57 G----DVSDEETITEAVNFIESKYKRLDGIVANAGV--LDPVEDVNNIHISK-WKQLFDI 109
DVS+ +TI F+++++ +LD +V NAGV + DV I++ ++
Sbjct: 90 SFHPLDVSNPDTIASLAAFVKTRFGKLDILVNNAGVGGANVNVDVLKAQIAEIVEECVKT 149
Query: 110 NFFSVVSLVGHALPLLKQSNG-NIVLVSS 137
N++ V + +PLL+ S+ IV ++S
Sbjct: 150 NYYGVKRMCEAMIPLLQSSDSPRIVSIAS 178
>Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 48.1 bits (113), Expect = 7e-06
Identities = 33/137 (24%), Positives = 65/137 (47%), Gaps = 4/137 (2%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDE 62
K +TG G G + +L + V+ ++ E+L+ Q S + + + DV+
Sbjct: 30 KYVFITGCDSGFGKLLARQLDARGLR--VLAACLTEKGAEQLRGQTSDRLETVTLDVTKT 87
Query: 63 ETITEAVNFIES--KYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGH 120
E++ A +++ + K L G+V NAG+ P + + D+N V+ + +
Sbjct: 88 ESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDLLTILDVNLLGVIDVTLN 147
Query: 121 ALPLLKQSNGNIVLVSS 137
LPL++++ G +V V S
Sbjct: 148 LLPLVRRARGRVVNVFS 164
>CE28291 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 357
Score = 48.1 bits (113), Expect = 7e-06
Identities = 39/145 (26%), Positives = 66/145 (44%), Gaps = 11/145 (7%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCS-----IETTKIVIGIARSKDKLEELKTQYSGKFDYICG 57
K + +TG + GIG L + + ++ + K ++EE K K D+I
Sbjct: 37 KTYAITGTTSGIGIETARALALKGAHVVMFNRNIVESEKLKKRIEEEKPDV--KIDFISC 94
Query: 58 DVSDEETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSL 117
D++ ++ A + SK+ L G++ NAGV P ++ F +N + L
Sbjct: 95 DLNSLQSAKAAADEFLSKHWPLHGLILNAGVFAPTV---KFTFDNFESHFGVNHLAQFLL 151
Query: 118 VGHALPLLKQSN-GNIVLVSSGAST 141
LP L+QS+ IV VSS +S+
Sbjct: 152 AKELLPALRQSSPARIVFVSSVSSS 176
>CE06157 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 255
Score = 48.1 bits (113), Expect = 7e-06
Identities = 31/134 (23%), Positives = 68/134 (50%), Gaps = 4/134 (2%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKT--QYSGKFDYICGDVS 60
K +TG +RGIG +V +L + + ++ AR+ D +EL++ + + I DVS
Sbjct: 4 KTIFITGANRGIGLGLVRELLKVPGVEALVAGARNIDGAKELQSLAKADARLHLIAVDVS 63
Query: 61 DEETITEAVNFIESKY--KRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLV 118
++ ++ +V + + L+ ++ NAG+++ + + + D+N S +
Sbjct: 64 NDGSLENSVKSVSGIVGDRGLNLLINNAGLIESYGTTSAPNRASVLHCIDVNAVSALLAS 123
Query: 119 GHALPLLKQSNGNI 132
H LPLL+++ ++
Sbjct: 124 QHFLPLLQKAASHV 137
>CE25799 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 265
Score = 47.8 bits (112), Expect = 9e-06
Identities = 36/128 (28%), Positives = 63/128 (49%), Gaps = 4/128 (3%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKT-QYSGKFDYICGDVSD 61
K ++TG +RGIG +V+ + +++I R+ +K +EL + + I +V D
Sbjct: 18 KNIMITGANRGIGFGLVKHFLEYDGIELLIATCRNPEKADELNALKNDRRLHVIALNVDD 77
Query: 62 EETITEAVNFIES--KYKRLDGIVANAGVLDPVE-DVNNIHISKWKQLFDINFFSVVSLV 118
+E+I + + + S L+ ++ NAG+L P E D I + + N SV L
Sbjct: 78 DESIKKVFDEVSSLVSSNGLNMLINNAGILLPYEVDGPKICRKTMMKQLETNSVSVAILT 137
Query: 119 GHALPLLK 126
LPL+K
Sbjct: 138 QIFLPLIK 145
>CE05726 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 47.8 bits (112), Expect = 9e-06
Identities = 39/143 (27%), Positives = 73/143 (50%), Gaps = 11/143 (7%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQY------SGKFDYIC 56
K ++TG S GIG S + + E ++ I R++D+LEE K Q + K + +
Sbjct: 7 KSVIITGSSNGIGRSAAV-IFAKEGAQVTI-TGRNEDRLEETKQQILKAGVPAEKINAVV 64
Query: 57 GDVSDEETITEAVNFIESKYKRLDGIVANAG--VLDPVEDVNNIHISKWKQLFDINFFSV 114
DV++ + +N +K+ ++D +V NAG + D + + + +++ F +NF +V
Sbjct: 65 ADVTEASGQDDIINTTLAKFGKIDILVNNAGANLADGTANTDQ-PVELYQKTFKLNFQAV 123
Query: 115 VSLVGHALPLLKQSNGNIVLVSS 137
+ + L ++ G IV VSS
Sbjct: 124 IEMTQKTKEHLIKTKGEIVNVSS 146
>At3g29250 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 47.8 bits (112), Expect = 9e-06
Identities = 34/140 (24%), Positives = 64/140 (45%), Gaps = 3/140 (2%)
Query: 3 KVFLVTGVSRGIGSSIVEKLCSIETTKIVIGIARSKDKLEELKTQYSGKFDYICGDVSDE 62
K+ ++TG + GIG+ V +++ I + + Y C +V+DE
Sbjct: 9 KIAIITGGASGIGAEAVRLFTDHGAKVVIVDIQEELGQNLAVSIGLDKASFYRC-NVTDE 67
Query: 63 ETITEAVNFIESKYKRLDGIVANAGVLDPVEDVNNIHISKWKQLFDINFFSVVSLVGHAL 122
+ AV F K+ +LD + +NAGVL+ V ++ + + + +N + + HA
Sbjct: 68 TDVENAVKFTVEKHGKLDVLFSNAGVLEAFGSVLDLDLEAFDRTMAVNVRGAAAFIKHAA 127
Query: 123 PLLKQS--NGNIVLVSSGAS 140
+ S G+IV +S A+
Sbjct: 128 RSMVASGTRGSIVCTTSIAA 147
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,537,329
Number of Sequences: 60738
Number of extensions: 421886
Number of successful extensions: 1570
Number of sequences better than 1.0e-05: 64
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 1493
Number of HSP's gapped (non-prelim): 65
length of query: 186
length of database: 30,389,216
effective HSP length: 100
effective length of query: 86
effective length of database: 24,315,416
effective search space: 2091125776
effective search space used: 2091125776
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)